                         SEQUENCE LISTING

<110>  Tufts Medical Center, Inc.
       Buchsbaum, Rachel J.
 
<120>  METHODS AND KITS FOR MODULATING TUMOR INVASIVENESS AND METASTATIC 
       POTENTIAL

<130>  34117-019

<150>  61/371,165
<151>  2010-08-05

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
gagactcctc cgtacagtaa t                                                 21


<210>  2
<211>  7218
<212>  DNA
<213>  Homo sapiens

<400>  2
gccccgcatc gtgcccggcc ccgtcgcgga gatcccggac gaccgtcgcg ggttgatggt       60

cgcattccag atgtaaacag cttcagaagc ctgacggtca tatggtagaa tcactgtgga      120

ctgagaccca cctttctaga cctgaagccc aggaggagga agaggaggct ggttggtacc      180

atgggcataa tgctctgaat cctagtctct cacctagtat gtgagcagtc cctgcagatg      240

gcccatttgg agatcttgac aaagcctctt ctgtttccaa tggggttttt ggcgcattct      300

cacagactta gatgaaactg tgatggccac cgcagggggc aggtgctgac atcgtcccca      360

gccctgtggc tgttcatccg gacatcattt ccaacctcaa tatctaaatg ccacagtgct      420

cttggagcaa gttgggctgg ggaccactgt tgccttttaa gaccataaaa ccatgggaaa      480

cgcagaaagt caacatgtag agcacgagtt ttatggagaa aagcatgcca gcctggggcg      540

caagcacact tcccgctccc tgcgcctctc gcacaagacg cggaggacca ggcacgcttc      600

ctcggggaag gtgatccaca ggaactccga agtgagcacc cgatccagca gcacccccag      660

catcccccag tccctggctg aaaatggcct ggagcccttc tcccaagatg gtaccctaga      720

agacttcggg agccccatct gggtggaccg agtggacatg ggcttgagac ctgtgtctta      780

cactgactct tctgtcactc ccagcgtaga cagcagcatc gtcctcacag cagcctctgt      840

gcagagcatg ccagacactg aggagagcag gctttacggg gatgacgcta catatttggc      900

tgagggaggc aggaggcagc attcctatac atccaatggg cccactttca tggagacggc      960

gagctttaag aagaaacgct ccaaatctgc agacatctgg cgggaggaca gcctggaatt     1020

ctcactctct gatctgagcc aagaacattt aacaagcaac gaagaaatct tgggttccgc     1080

cgaagagaag gactgcgagg aggctcgggg gatggaaacg cgggcgagtc cgcggcagct     1140

cagcacctgt cagagagcca attccttggg tgacttgtat gctcagaaaa actctggagt     1200

gacagcaaac ggggggccgg ggagcaaatt tgcaggctac tgtcggaatt tggtgtctga     1260

tattcccaat cttgcaaacc ataagatgcc accagctgct gctgaagaga ctcctccgta     1320

cagtaattat aacacacttc cctgtaggaa atctcactgt ctctctgaag gtgccaccaa     1380

cccacaaatt agccatagca acagcatgca aggcagaaga gctaaaacaa ctcaggatgt     1440

taatgcaggc gagggcagtg agtttgcaga cagtgggatt gaaggggcca ctaccgacac     1500

ggacctcctg tccaggcgat ctaatgccac caactccagc tactcaccca ccacaggccg     1560

ggcctttgtg ggcagcgaca gcggcagcag ctccaccggg gatgcggctc gtcagggggt     1620

gtacgagaac ttccggcggg agctggagat gagcaccacc aacagcgaga gcctggagga     1680

ggccggctcg gcgcacagcg atgagcagag cagcggcacc ctgagctctc cgggccagtc     1740

ggacatcctg ctgaccgccg cacagggcac ggtgcgcaag gccggcgccc tggccgtcaa     1800

gaacttcctg gtgcacaaga agaacaagaa ggtggagtca gccacccgga ggaagtggaa     1860

gcactactgg gtgtccctga aaggatgcac gctatttttc tacgagagcg acggcaggtc     1920

tgggatagac cacaacagca tccccaaaca cgccgtctgg gtggagaaca gcattgtgca     1980

ggcggtgcct gagcacccca agaaggactt tgtcttctgc ctcagcaatt ccctgggtga     2040

tgccttcctt tttcagacca ctagccagac ggagcttgaa aactggatca ccgccatcca     2100

ctctgcctgc gccactgcgg tcgcgaggca ccaccacaag gaagacacgc tccgactcct     2160

gaaatcagag atcaaaaaac tggaacagaa gattgacatg gatgaaaaga tgaagaaaat     2220

gggtgaaatg cagctgtctt cagtcactga ctcaaagaaa aagaaaacaa tattagatca     2280

gatctttgtc tgggagcaaa atctcgagca gttccaaatg gacctgtttc gtttccgctg     2340

ttatttagcc agccttcagg gtggggagct gccaaacccc aaaaggcttc tcgcttttgc     2400

aagtcgacca acgaaagtgg ccatgggccg ccttggaatc ttttcggtat catcgtttca     2460

tgccctggtg gcagcacgca ctggtgaaac tggagtgaga agacgtactc aggccatgtc     2520

cagatccgcg agcaagcgaa ggagcaggtt ttcttctctg tggggtctgg atactacctc     2580

caaaaagaag cagggacggc caagcatcaa tcaggtgttt ggagagggaa ccgaagctgt     2640

aaagaaatct ttagagggaa tatttgatga cattgttcca gatggcaaga gggagaaaga     2700

agtggtctta cctaacgttc accagcacaa ccctgactgc gacatttggg tccacgagta     2760

tttcactcca tcctggttct gtctgcccaa taatcagcct gccctgacgg tcgtccggcc     2820

aggcgacact gcacgggaca ccctggagct gatttgcaag acacatcaac tggatcattc     2880

tgctcattac ctgcgcctga aatttctaat agaaaacaaa atgcagctct atgttccaca     2940

gcccgaggaa gacatctatg agctgctgta caaagaaatt gaaatctgtc caaaagtcac     3000

tcagagcatc cacattgaga agtcagatac agctgctgat acttacgggt tttcactttc     3060

ttctgtggaa gaagatggta ttcgaaggct gtacgtgaat agtgtgaagg aaaccggttt     3120

agcttccaag aaaggcctga aagcaggaga tgagattctt gagatcaata atcgtgctgc     3180

tgacgccctg aactcttcta tgctcaaaga tttcctctca cagccctcgc tgggcctcct     3240

ggtgaggacc taccccgagc tggaggaagg agtggagctg ctggaaagcc cgccccaccg     3300

agtggacggc cctgccgacc ttggcgagag ccccctcgcc tttctcacca gcaacccagg     3360

gcacagcctt tgcagcgagc agggcagcag tgctgagacc gctccagagg agaccgaggg     3420

gccagacttg gaatcctcag atgagactga tcacagcagc aagagtacag aacaggtggc     3480

cgcattttgc cgcagtttgc atgagatgaa cccctctgac cagagcccat ctcctcagga     3540

ctccacgggg cctcagctgg cgaccatgag acaactctcg gatgcagata agctgcgcaa     3600

ggtgatctgc gagctcctgg agacggagcg cacctacgtg aaggatttaa actgtcttat     3660

ggagagatac ctaaagcctc ttcaaaaaga aacttttctc acccaggatg agcttgacgt     3720

gctttttgga aatttaacgg aaatggtaga gtttcaagta gaattcctta aaactctaga     3780

agatggagtg agactggtac ctgatttgga aaagcttgag aaggttgatc aatttaagaa     3840

agtgctgttc tctctggggg gatcattcct gtattatgct gaccgcttca agctctacag     3900

tgccttctgc gccagccaca caaaagttcc caaggtcctg gtgaaagcca agacagacac     3960

ggctttcaag gcattcttgg atgcccagaa cccgaagcag cagcactcat ccacgctgga     4020

gtcgtacctc atcaagccca tccagaggat cctcaagtac ccacttctgc tcagggagct     4080

gttcgccctg accgatgcgg agagcgagga gcactaccac ctggacgtgg ccatcaagac     4140

catgaacaag gttgccagtc acatcaatga gatgcagaaa atccatgaag agtttggggc     4200

tgtgtttgac cagctgattg ctgaacagac tggtgagaaa aaagaggttg cagatctgag     4260

catgggagac ctgcttttgc acactaccgt gatctggctg aacccgccgg cctcgctggg     4320

caagtggaaa aaggaaccag agttggcagc attcgtcttc aaaactgctg tggtccttgt     4380

gtataaagat ggttccaaac agaagaagaa acttgtagga tctcacaggc tttccattta     4440

tgaggactgg gaccccttca gatttcgaca catgatcccc acggaagcgc tgcaggttcg     4500

agctttggcg agtgcagatg cagaggcaaa tgccgtgtgt gaaattgtcc atgtaaaatc     4560

cgagtctgaa gggaggccgg agagggtctt tcacttgtgc tgcagctccc cagagagccg     4620

aaaggatttc ctaaaggctg tgcattcaat cctgcgtgat aagcacagaa gacagctcct     4680

caaaaccgag agccttccct catcccagca atatgtccct tttggaggca aaagattgtg     4740

tgcactgaag ggggccaggc cggccatgag cagggcagtg tctgccccaa gcaagtctct     4800

tgggaggagg aggcggcggc tggctcgaaa caggtttacc attgattctg atgccgtctc     4860

cgcaagcagc ccggagaaag agtcccagca gccccccggt ggtggggaca ctgaccgatg     4920

ggtagaggag cagtttgatc ttgctcagta tgaggagcaa gatgacatca aggagacaga     4980

catcctcagt gacgatgatg agttctgtga gtccgtgaag ggtgcctcag tggacagaga     5040

cctgcaggag cggcttcagg ccacctccat cagtcagcgg gaaagaggcc ggaaaaccct     5100

ggatagtcac gcgtcccgca tggcacagct caagaagcaa gctgccctgt cggggatcaa     5160

tggaggcctg gagagcgcaa gcgaggaagt catttgggtt aggcgtgaag actttgcccc     5220

ctccaggaaa ctgaacactg agatctgact gcgtcacctg ccccgtagag aatgtgtgta     5280

gatacttcct gccctaactc tgcccaccct cctgtaccgt cgacaagaat gtccccttag     5340

gtcgcgctct tgcacacacg gttttggcag ctgacttggt tctgaagcca tgtagccacc     5400

caactttgtc attttcaaca acatcagaaa gaattgatca gaatcccaaa taagcttgag     5460

tcctatcttc tgtatattac taagggcttt tatttattct caataaatca gggcctgaac     5520

aattaaaaga aaaaagattc tatagcactg gaaagcaaat caccccagga gttaacggat     5580

gtacaacaga ttaatttaag ggatagtagc acacacacga tccttctatc tgaaatcagt     5640

ctcctagctg gggaaacctc tttcacacac aaaatgaaat gtgtacagct tgccgtgttc     5700

tgactgtacc cttccctctt ccatgtctga gaatctccgt gtattttaag aatgtgtgag     5760

gagagggtgg cgattcatgt ttcaatgagc ctcttttttt ttttccttcc tgttttggtc     5820

tatggctggt cttactctgt gtccatgttc ggaagctcta gttttgcata gaattataga     5880

gatgccaaac tctttgaaaa gagatccaaa tttatcgctt gagagaaaga aaagaaacac     5940

tattttttgt attttacctg agatacaggg gcacaaatag atgagaattt tacagtgtta     6000

gtgtatgtat ccctgagcct aaaaaatgag gatataacct tttacagaga gagtgaggcg     6060

tggtggtttt atatttatat atgaaaggcc agcaagctca tgcgaaggat atacttttct     6120

tccaaaaagc ggattttttt tttttaatgt ttgaatctat atttgagatg ggagtttggt     6180

tggattaaac atgacacccc ggtgggcggt gtgtgtgtct gttgcacatg gcagggaggg     6240

gagcctcctt ctcatggggt tgccatggtg atcattggtt tttccatcaa aattgcatct     6300

tcatccatag attaccttcc ccttccctga cagtccataa ccaaaccttt aaacagaaca     6360

acctctttaa aaacttctct tgtgtttaac actttcttca tgccaacgaa acagggtaaa     6420

catgctcaaa acattaacag tctaaacaga tatccaaata ctaagaagaa aaacaagtta     6480

tagcactttc aatttttttt ttttttttaa aaaaaggttt atagcttttt cttttcccat     6540

gtcacaatgt ccacttccta agaagggttt aaaatactat gaaaactttc tttttgggga     6600

aaatatctat ttggtgtttg acacatcagt aggtacttta aagacctgaa ttttatagta     6660

gctttaggag ttatatttta taaaaatcag ttatgacttt atatttccag acaatagaga     6720

gttcagtaca tcatgctctt gtgcctctgc ctgcttttcc tgcgttccca ccctgtattc     6780

cccccgcctt tcgggtttcc agggcttcga gcttgatctt ttgaaagttt tattctatta     6840

aatttttgct atatcttctg gttttctgaa aaagctttag aatggtttct ataccctttg     6900

tatcactgca tttttccata tcatctccgg ttcgatcgcg tccagatgga aaacggaagc     6960

agaggcttct aatcgtcgca tttactggct ccagtgcaac acatccatct gaaaacactc     7020

ggaagtctgg tgcttggaga gggtgccatt gtctcttgta cataaggtca tgacgtgtct     7080

atgtcaaaag ttcttatata tttcttttat aagctgaaag aaggtctatt tttatgtttt     7140

taggtctatg aatggaacgt tgtaaatgct tgtcaaacaa taaaaataac gaaaagtgaa     7200

aaaaaaaaaa aaaaaaaa                                                   7218


<210>  3
<211>  1591
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Asn Ala Glu Ser Gln His Val Glu His Glu Phe Tyr Gly Glu 
1               5                   10                  15      


Lys His Ala Ser Leu Gly Arg Lys His Thr Ser Arg Ser Leu Arg Leu 
            20                  25                  30          


Ser His Lys Thr Arg Arg Thr Arg His Ala Ser Ser Gly Lys Val Ile 
        35                  40                  45              


His Arg Asn Ser Glu Val Ser Thr Arg Ser Ser Ser Thr Pro Ser Ile 
    50                  55                  60                  


Pro Gln Ser Leu Ala Glu Asn Gly Leu Glu Pro Phe Ser Gln Asp Gly 
65                  70                  75                  80  


Thr Leu Glu Asp Phe Gly Ser Pro Ile Trp Val Asp Arg Val Asp Met 
                85                  90                  95      


Gly Leu Arg Pro Val Ser Tyr Thr Asp Ser Ser Val Thr Pro Ser Val 
            100                 105                 110         


Asp Ser Ser Ile Val Leu Thr Ala Ala Ser Val Gln Ser Met Pro Asp 
        115                 120                 125             


Thr Glu Glu Ser Arg Leu Tyr Gly Asp Asp Ala Thr Tyr Leu Ala Glu 
    130                 135                 140                 


Gly Gly Arg Arg Gln His Ser Tyr Thr Ser Asn Gly Pro Thr Phe Met 
145                 150                 155                 160 


Glu Thr Ala Ser Phe Lys Lys Lys Arg Ser Lys Ser Ala Asp Ile Trp 
                165                 170                 175     


Arg Glu Asp Ser Leu Glu Phe Ser Leu Ser Asp Leu Ser Gln Glu His 
            180                 185                 190         


Leu Thr Ser Asn Glu Glu Ile Leu Gly Ser Ala Glu Glu Lys Asp Cys 
        195                 200                 205             


Glu Glu Ala Arg Gly Met Glu Thr Arg Ala Ser Pro Arg Gln Leu Ser 
    210                 215                 220                 


Thr Cys Gln Arg Ala Asn Ser Leu Gly Asp Leu Tyr Ala Gln Lys Asn 
225                 230                 235                 240 


Ser Gly Val Thr Ala Asn Gly Gly Pro Gly Ser Lys Phe Ala Gly Tyr 
                245                 250                 255     


Cys Arg Asn Leu Val Ser Asp Ile Pro Asn Leu Ala Asn His Lys Met 
            260                 265                 270         


Pro Pro Ala Ala Ala Glu Glu Thr Pro Pro Tyr Ser Asn Tyr Asn Thr 
        275                 280                 285             


Leu Pro Cys Arg Lys Ser His Cys Leu Ser Glu Gly Ala Thr Asn Pro 
    290                 295                 300                 


Gln Ile Ser His Ser Asn Ser Met Gln Gly Arg Arg Ala Lys Thr Thr 
305                 310                 315                 320 


Gln Asp Val Asn Ala Gly Glu Gly Ser Glu Phe Ala Asp Ser Gly Ile 
                325                 330                 335     


Glu Gly Ala Thr Thr Asp Thr Asp Leu Leu Ser Arg Arg Ser Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Tyr Ser Pro Thr Thr Gly Arg Ala Phe Val Gly Ser 
        355                 360                 365             


Asp Ser Gly Ser Ser Ser Thr Gly Asp Ala Ala Arg Gln Gly Val Tyr 
    370                 375                 380                 


Glu Asn Phe Arg Arg Glu Leu Glu Met Ser Thr Thr Asn Ser Glu Ser 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Ser Ala His Ser Asp Glu Gln Ser Ser Gly Thr 
                405                 410                 415     


Leu Ser Ser Pro Gly Gln Ser Asp Ile Leu Leu Thr Ala Ala Gln Gly 
            420                 425                 430         


Thr Val Arg Lys Ala Gly Ala Leu Ala Val Lys Asn Phe Leu Val His 
        435                 440                 445             


Lys Lys Asn Lys Lys Val Glu Ser Ala Thr Arg Arg Lys Trp Lys His 
    450                 455                 460                 


Tyr Trp Val Ser Leu Lys Gly Cys Thr Leu Phe Phe Tyr Glu Ser Asp 
465                 470                 475                 480 


Gly Arg Ser Gly Ile Asp His Asn Ser Ile Pro Lys His Ala Val Trp 
                485                 490                 495     


Val Glu Asn Ser Ile Val Gln Ala Val Pro Glu His Pro Lys Lys Asp 
            500                 505                 510         


Phe Val Phe Cys Leu Ser Asn Ser Leu Gly Asp Ala Phe Leu Phe Gln 
        515                 520                 525             


Thr Thr Ser Gln Thr Glu Leu Glu Asn Trp Ile Thr Ala Ile His Ser 
    530                 535                 540                 


Ala Cys Ala Thr Ala Val Ala Arg His His His Lys Glu Asp Thr Leu 
545                 550                 555                 560 


Arg Leu Leu Lys Ser Glu Ile Lys Lys Leu Glu Gln Lys Ile Asp Met 
                565                 570                 575     


Asp Glu Lys Met Lys Lys Met Gly Glu Met Gln Leu Ser Ser Val Thr 
            580                 585                 590         


Asp Ser Lys Lys Lys Lys Thr Ile Leu Asp Gln Ile Phe Val Trp Glu 
        595                 600                 605             


Gln Asn Leu Glu Gln Phe Gln Met Asp Leu Phe Arg Phe Arg Cys Tyr 
    610                 615                 620                 


Leu Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Arg Leu Leu 
625                 630                 635                 640 


Ala Phe Ala Ser Arg Pro Thr Lys Val Ala Met Gly Arg Leu Gly Ile 
                645                 650                 655     


Phe Ser Val Ser Ser Phe His Ala Leu Val Ala Ala Arg Thr Gly Glu 
            660                 665                 670         


Thr Gly Val Arg Arg Arg Thr Gln Ala Met Ser Arg Ser Ala Ser Lys 
        675                 680                 685             


Arg Arg Ser Arg Phe Ser Ser Leu Trp Gly Leu Asp Thr Thr Ser Lys 
    690                 695                 700                 


Lys Lys Gln Gly Arg Pro Ser Ile Asn Gln Val Phe Gly Glu Gly Thr 
705                 710                 715                 720 


Glu Ala Val Lys Lys Ser Leu Glu Gly Ile Phe Asp Asp Ile Val Pro 
                725                 730                 735     


Asp Gly Lys Arg Glu Lys Glu Val Val Leu Pro Asn Val His Gln His 
            740                 745                 750         


Asn Pro Asp Cys Asp Ile Trp Val His Glu Tyr Phe Thr Pro Ser Trp 
        755                 760                 765             


Phe Cys Leu Pro Asn Asn Gln Pro Ala Leu Thr Val Val Arg Pro Gly 
    770                 775                 780                 


Asp Thr Ala Arg Asp Thr Leu Glu Leu Ile Cys Lys Thr His Gln Leu 
785                 790                 795                 800 


Asp His Ser Ala His Tyr Leu Arg Leu Lys Phe Leu Ile Glu Asn Lys 
                805                 810                 815     


Met Gln Leu Tyr Val Pro Gln Pro Glu Glu Asp Ile Tyr Glu Leu Leu 
            820                 825                 830         


Tyr Lys Glu Ile Glu Ile Cys Pro Lys Val Thr Gln Ser Ile His Ile 
        835                 840                 845             


Glu Lys Ser Asp Thr Ala Ala Asp Thr Tyr Gly Phe Ser Leu Ser Ser 
    850                 855                 860                 


Val Glu Glu Asp Gly Ile Arg Arg Leu Tyr Val Asn Ser Val Lys Glu 
865                 870                 875                 880 


Thr Gly Leu Ala Ser Lys Lys Gly Leu Lys Ala Gly Asp Glu Ile Leu 
                885                 890                 895     


Glu Ile Asn Asn Arg Ala Ala Asp Ala Leu Asn Ser Ser Met Leu Lys 
            900                 905                 910         


Asp Phe Leu Ser Gln Pro Ser Leu Gly Leu Leu Val Arg Thr Tyr Pro 
        915                 920                 925             


Glu Leu Glu Glu Gly Val Glu Leu Leu Glu Ser Pro Pro His Arg Val 
    930                 935                 940                 


Asp Gly Pro Ala Asp Leu Gly Glu Ser Pro Leu Ala Phe Leu Thr Ser 
945                 950                 955                 960 


Asn Pro Gly His Ser Leu Cys Ser Glu Gln Gly Ser Ser Ala Glu Thr 
                965                 970                 975     


Ala Pro Glu Glu Thr Glu Gly Pro Asp Leu Glu Ser Ser Asp Glu Thr 
            980                 985                 990         


Asp His Ser Ser Lys Ser Thr Glu  Gln Val Ala Ala Phe  Cys Arg Ser 
        995                 1000                 1005             


Leu His  Glu Met Asn Pro Ser  Asp Gln Ser Pro Ser  Pro Gln Asp 
    1010                 1015                 1020             


Ser Thr  Gly Pro Gln Leu Ala  Thr Met Arg Gln Leu  Ser Asp Ala 
    1025                 1030                 1035             


Asp Lys  Leu Arg Lys Val Ile  Cys Glu Leu Leu Glu  Thr Glu Arg 
    1040                 1045                 1050             


Thr Tyr  Val Lys Asp Leu Asn  Cys Leu Met Glu Arg  Tyr Leu Lys 
    1055                 1060                 1065             


Pro Leu  Gln Lys Glu Thr Phe  Leu Thr Gln Asp Glu  Leu Asp Val 
    1070                 1075                 1080             


Leu Phe  Gly Asn Leu Thr Glu  Met Val Glu Phe Gln  Val Glu Phe 
    1085                 1090                 1095             


Leu Lys  Thr Leu Glu Asp Gly  Val Arg Leu Val Pro  Asp Leu Glu 
    1100                 1105                 1110             


Lys Leu  Glu Lys Val Asp Gln  Phe Lys Lys Val Leu  Phe Ser Leu 
    1115                 1120                 1125             


Gly Gly  Ser Phe Leu Tyr Tyr  Ala Asp Arg Phe Lys  Leu Tyr Ser 
    1130                 1135                 1140             


Ala Phe  Cys Ala Ser His Thr  Lys Val Pro Lys Val  Leu Val Lys 
    1145                 1150                 1155             


Ala Lys  Thr Asp Thr Ala Phe  Lys Ala Phe Leu Asp  Ala Gln Asn 
    1160                 1165                 1170             


Pro Lys  Gln Gln His Ser Ser  Thr Leu Glu Ser Tyr  Leu Ile Lys 
    1175                 1180                 1185             


Pro Ile  Gln Arg Ile Leu Lys  Tyr Pro Leu Leu Leu  Arg Glu Leu 
    1190                 1195                 1200             


Phe Ala  Leu Thr Asp Ala Glu  Ser Glu Glu His Tyr  His Leu Asp 
    1205                 1210                 1215             


Val Ala  Ile Lys Thr Met Asn  Lys Val Ala Ser His  Ile Asn Glu 
    1220                 1225                 1230             


Met Gln  Lys Ile His Glu Glu  Phe Gly Ala Val Phe  Asp Gln Leu 
    1235                 1240                 1245             


Ile Ala  Glu Gln Thr Gly Glu  Lys Lys Glu Val Ala  Asp Leu Ser 
    1250                 1255                 1260             


Met Gly  Asp Leu Leu Leu His  Thr Thr Val Ile Trp  Leu Asn Pro 
    1265                 1270                 1275             


Pro Ala  Ser Leu Gly Lys Trp  Lys Lys Glu Pro Glu  Leu Ala Ala 
    1280                 1285                 1290             


Phe Val  Phe Lys Thr Ala Val  Val Leu Val Tyr Lys  Asp Gly Ser 
    1295                 1300                 1305             


Lys Gln  Lys Lys Lys Leu Val  Gly Ser His Arg Leu  Ser Ile Tyr 
    1310                 1315                 1320             


Glu Asp  Trp Asp Pro Phe Arg  Phe Arg His Met Ile  Pro Thr Glu 
    1325                 1330                 1335             


Ala Leu  Gln Val Arg Ala Leu  Ala Ser Ala Asp Ala  Glu Ala Asn 
    1340                 1345                 1350             


Ala Val  Cys Glu Ile Val His  Val Lys Ser Glu Ser  Glu Gly Arg 
    1355                 1360                 1365             


Pro Glu  Arg Val Phe His Leu  Cys Cys Ser Ser Pro  Glu Ser Arg 
    1370                 1375                 1380             


Lys Asp  Phe Leu Lys Ala Val  His Ser Ile Leu Arg  Asp Lys His 
    1385                 1390                 1395             


Arg Arg  Gln Leu Leu Lys Thr  Glu Ser Leu Pro Ser  Ser Gln Gln 
    1400                 1405                 1410             


Tyr Val  Pro Phe Gly Gly Lys  Arg Leu Cys Ala Leu  Lys Gly Ala 
    1415                 1420                 1425             


Arg Pro  Ala Met Ser Arg Ala  Val Ser Ala Pro Ser  Lys Ser Leu 
    1430                 1435                 1440             


Gly Arg  Arg Arg Arg Arg Leu  Ala Arg Asn Arg Phe  Thr Ile Asp 
    1445                 1450                 1455             


Ser Asp  Ala Val Ser Ala Ser  Ser Pro Glu Lys Glu  Ser Gln Gln 
    1460                 1465                 1470             


Pro Pro  Gly Gly Gly Asp Thr  Asp Arg Trp Val Glu  Glu Gln Phe 
    1475                 1480                 1485             


Asp Leu  Ala Gln Tyr Glu Glu  Gln Asp Asp Ile Lys  Glu Thr Asp 
    1490                 1495                 1500             


Ile Leu  Ser Asp Asp Asp Glu  Phe Cys Glu Ser Val  Lys Gly Ala 
    1505                 1510                 1515             


Ser Val  Asp Arg Asp Leu Gln  Glu Arg Leu Gln Ala  Thr Ser Ile 
    1520                 1525                 1530             


Ser Gln  Arg Glu Arg Gly Arg  Lys Thr Leu Asp Ser  His Ala Ser 
    1535                 1540                 1545             


Arg Met  Ala Gln Leu Lys Lys  Gln Ala Ala Leu Ser  Gly Ile Asn 
    1550                 1555                 1560             


Gly Gly  Leu Glu Ser Ala Ser  Glu Glu Val Ile Trp  Val Arg Arg 
    1565                 1570                 1575             


Glu Asp  Phe Ala Pro Ser Arg  Lys Leu Asn Thr Glu  Ile 
    1580                 1585                 1590     


<210>  4
<211>  29
<212>  DNA
<213>  Homo sapiens

<400>  4
cgggatccat gggaaacgca gaaagtcaa                                         29


<210>  5
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  5
ccactttcgt tgtcgact                                                     18


<210>  6
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  6
gagctgccaa accccaaa                                                     18


<210>  7
<211>  31
<212>  DNA
<213>  Homo sapiens

<400>  7
atagtcgacg atctcagtgt tcagtttcct c                                      31


<210>  8
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  8
ataagaagcg gccgcatggg aaacgcagaa agtcaa                                 36


<210>  9
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  9
caccctttac aacaaatacc cagatttcaa gagaatctgg gtatttgttg taaag            55


<210>  10
<211>  55
<212>  DNA
<213>  Homo sapiens

<400>  10
aaaactttac aacaaatacc cagattctct tgaaatctgg gtatttgttg taaag            55


<210>  11
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  11
aagacgtact caggccatgt cc                                                22


<210>  12
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  12
gacccaaatg tcgcagtcag                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  13
gccataccag ttaaacaggc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  14
gacctcagaa gatgcactat                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  15
ctcccggtga aagtgactga                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  16
gacctcagaa gatgaactct                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  17
ctgcaccacc aactgcttag                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  18
ttcagctcag ggatgacctt                                                   20


<210>  19
<211>  25
<212>  DNA
<213>  Mus musculus

<400>  19
tggaatcctg tggcatccat gaaac                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Mus musculus

<400>  20
taaaacgcag ctcagtaaca gtccg                                             25


