
                                SEQUENCE LISTING

<110> Lalita Samant
      Rajeev Samant

<120> METHODS AND COMPOSITIONS FOR THE
  DIAGNOSIS AND TREATMENT OF BREAST CANCER
  

<130> USA.009WO

<150> 61/400823           
<151> 2010-08-03  

<160> 78

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-let-7c

<400> 1
ugagguagua gguuguaugg uu                                          22

<210> 2
<211> 21
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(21)
<223> hsa-miR-296-5p

<400> 2
agggcccccc cucaauccug u                                           21

<210> 3
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-296-3p

<400> 3
gaggguuggg uggaggcucu cc                                          22

<210> 4
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-let-7d

<400> 4
agagguagua gguugcauag uu                                          22

<210> 5
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-30c

<400> 5
uguaaacauc cuacacucuc agc                                         23

<210> 6
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-20a

<400> 6
uaaagugcuu auagugcagg uag                                         23

<210> 7
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-494

<400> 7
ugaaacauac acgggaaacc uc                                          22

<210> 8
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-320a

<400> 8
aaaagcuggg uugagagggc ga                                          22

<210> 9
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-320b

<400> 9
aaaagcuggg uugagagggc aa                                          22

<210> 10
<211> 20
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(20)
<223> hsa-miR-320c

<400> 10
aaaagcuggg uugagagggu                                             20

<210> 11
<211> 19
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(19)
<223> hsa-miR-320d

<400> 11
aaaagcuggg uugagagga                                              19

<210> 12
<211> 18
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(18)
<223> hsa-miR-320e

<400> 12
aaagcugggu ugagaagg                                               18

<210> 13
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-498

<400> 13
uuucaagcca gggggcguuu uuc                                         23

<210> 14
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-382

<400> 14
gaaguuguuc gugguggauu cg                                          22

<210> 15
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-185

<400> 15
uggagagaaa ggcaguuccu ga                                          22

<210> 16
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-99b

<400> 16
cacccguaga accgaccuug cg                                          22

<210> 17
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-let-7a

<400> 17
ugagguagua gguuguauag uu                                          22

<210> 18
<211> 20
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(20)
<223> hsa-miR-527

<400> 18
cugcaaaggg aagcccuuuc                                             20

<210> 19
<211> 21
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(21)
<223> hsa-miR-195

<400> 19
uagcagcaca gaaauauugg c                                           21

<210> 20
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-510

<400> 20
uacucaggag aguggcaauc ac                                          22

<210> 21
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-130b

<400> 21
cagugcaaug augaaagggc au                                          22

<210> 22
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-361-5p

<400> 22
uuaucagaau cuccaggggu ac                                          22

<210> 23
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-361-3p

<400> 23
ucccccaggu gugauucuga uuu                                         23

<210> 24
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-184

<400> 24
uggacggaga acugauaagg gu                                          22

<210> 25
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-198

<400> 25
gguccagagg ggagauaggu uc                                          22

<210> 26
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-487b

<400> 26
aaucguacag ggucauccac uu                                          22

<210> 27
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-let-7b

<400> 27
ugagguagua gguugugugg uu                                          22

<210> 28
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-214

<400> 28
acagcaggca cagacaggca gu                                          22

<210> 29
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-346

<400> 29
ugucugcccg caugccugcc ucu                                         23

<210> 30
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-let-7e

<400> 30
ugagguagga gguuguauag uu                                          22

<210> 31
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-335

<400> 31
ugagguagga gguuguauag uu                                          22

<210> 32
<211> 24
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(24)
<223> hsa-miR-125a-5p

<400> 32
ucccugagac ccuuuaaccu guga                                        24

<210> 33
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-125a-3p

<400> 33
acaggugagg uucuugggag cc                                          22

<210> 34
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-519d

<400> 34
caaagugccu cccuuuagag ug                                          22

<210> 35
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-423-5p

<400> 35
ugaggggcag agagcgagac uuu                                         23

<210> 36
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-423-3p

<400> 36
agcucggucu gaggccccuc agu                                         23

<210> 37
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-503

<400> 37
uagcagcggg aacaguucug cag                                         23

<210> 38
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-324-5p

<400> 38
cgcauccccu agggcauugg ugu                                         23

<210> 39
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-518f*

<400> 39
cucuagaggg aagcacuuuc uc                                          22

<210> 40
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-518e*; hsa-miR-518d-5p

<400> 40
cucuagaggg aagcacuuuc ug                                          22

<210> 41
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-519a*; hsa-miR-519b-5p; hsa-miR-519c-5p

<400> 41
cucuagaggg aagcgcuuuc ug                                          22

<210> 42
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-520c-5p

<400> 42
cucuagaggg aagcacuuuc ug                                          22

<210> 43
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-522*; hsa-miR-523*

<400> 43
cucuagaggg aagcgcuuuc ug                                          22

<210> 44
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-526a

<400> 44
cucuagaggg aagcacuuuc ug                                          22

<210> 45
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-526b

<400> 45
cucuugaggg aagcacuuuc ugu                                         23

<210> 46
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-134

<400> 46
ugugacuggu ugaccagagg gg                                          22

<210> 47
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-452

<400> 47
aacuguuugc agaggaaacu ga                                          22

<210> 48
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-494

<400> 48
ugaaacauac acgggaaacc uc                                          22

<210> 49
<211> 20
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(20)
<223> hsa-miR-202

<400> 49
agagguauag ggcaugggaa                                             20

<210> 50
<211> 18
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(18)
<223> hsa-miR-513-5p

<400> 50
uucacaggga ggugucau                                               18

<210> 51
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-513-3p

<400> 51
uaaauuucac cuuucugaga agg                                         23

<210> 52
<211> 20
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(20)
<223> hsa-miR-490-5p

<400> 52
ccauggaucu ccaggugggu                                             20

<210> 53
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-490-3p

<400> 53
caaccuggag gacuccaugc ug                                          22

<210> 54
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-208a

<400> 54
auaagacgag caaaaagcuu gu                                          22

<210> 55
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-208b

<400> 55
auaagacgaa caaaagguuu gu                                          22

<210> 56
<211> 21
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(21)
<223> hsa-miR-525-5p

<400> 56
cuccagaggg augcacuuuc u                                           21

<210> 57
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-525-3p

<400> 57
gaaggcgcuu cccuuuagag cg                                          22

<210> 58
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-24-1

<400> 58
uggcucaguu cagcaggaac ag                                          22

<210> 59
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-24-2

<400> 59
uggcucaguu cagcaggaac ag                                          22

<210> 60
<211> 21
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(21)
<223> hsa-miR-23b

<400> 60
aucacauugc cagggauuac c                                           21

<210> 61
<211> 21
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(21)
<223> hsa-miR-222

<400> 61
agcuacaucu ggcuacuggg u                                           21

<210> 62
<211> 18
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(18)
<223> hsa-miR-516-3p

<400> 62
ugcuuccuuu cagagggu                                               18

<210> 63
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-377

<400> 63
aucacacaaa ggcaacuuuu gu                                          22

<210> 64
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-199a-5p

<400> 64
cccaguguuc agacuaccug uuc                                         23

<210> 65
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-199a-3p

<400> 65
acaguagucu gcacauuggu ua                                          22

<210> 66
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-155

<400> 66
uuaaugcuaa ucgugauagg ggu                                         23

<210> 67
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-223

<400> 67
ugucaguuug ucaaauaccc ca                                          22

<210> 68
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-299-5p

<400> 68
ugguuuaccg ucccacauac au                                          22

<210> 69
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-325

<400> 69
ccuaguaggu guccaguaag ugu                                         23

<210> 70
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-367

<400> 70
aauugcacuu uagcaauggu ga                                          22

<210> 71
<211> 21
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(21)
<223> hsa-miR-379

<400> 71
ugguagacua uggaacguag g                                           21

<210> 72
<211> 23
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(23)
<223> hsa-miR-323b-5p

<400> 72
agguuguccg uggugaguuc gca                                         23

<210> 73
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-323b-3p

<400> 73
cccaauacac ggucgaccuc uu                                          22

<210> 74
<211> 22
<212> RNA
<213> Homo Sapiens

<220> 
<221> misc_RNA       
<222> (1)...(22)
<223> hsa-miR-522

<400> 74
aaaaugguuc ccuuuagagu gu                                          22

<210> 75
<211> 6046
<212> DNA
<213> Homo Sapiens

<220> 
<221> prim_transcript
<222> (1)...(6046)
<223> Merlin mRNA

<400> 75
tgcgcttccc gcgggcgcgc ggagtgagga cggtgacagc cacgcgcgcg cgtacgcgcc 60
cgatgcagcg cggccccgtg accctagtcg gccgctgaga ggcgcgcgga gtctgggccg 120
ctgccgtcta ggggtcccgt cccgaggcgt ccccggcatc tccggcccga atcccggagt 180
gccgggtcgc gcctgcaccg aaggtcccgg ctcctgtgcc ctccctgcag ccgtcagggc 240
ccgtccccca actccccttt ccgctcaggc agggtcctcg cggcccatgc tggccgctgg 300
ggacccgcgc agcccagacc gttcccgggc cgggcagccg gccaccatgg tggccctgag 360
gcctgtgcag caactccagg ggggctaaag ggctcagagt gcaggccgtg gggcgcgagg 420
gtcccgggcc tgagccccgc gccatggccg gggccatcgc ttcccgcatg agcttcagct 480
ctctcaagag gaagcaaccc aagacgttca ccgtgaggat cgtcaccatg gacgccgaga 540
tggagttcaa ttgcgagatg aagtggaaag ggaaggacct ctttgatttg gtgtgccgga 600
ctctggggct ccgagaaacc tggttctttg gactgcagta cacaatcaag gacacagtgg 660
cctggctcaa aatggacaag aaggtactgg atcatgatgt ttcaaaggaa gaaccagtca 720
cctttcactt cttggccaaa ttttatcctg agaatgctga agaggagctg gttcaggaga 780
tcacacaaca tttattcttc ttacaggtaa agaagcagat tttagatgaa aagatctact 840
gccctcctga ggcttctgtg ctcctggctt cttacgccgt ccaggccaag tatggtgact 900
acgaccccag tgttcacaag cggggatttt tggcccaaga ggaattgctt ccaaaaaggg 960
taataaatct gtatcagatg actccggaaa tgtgggagga gagaattact gcttggtacg 1020
cagagcaccg aggccgagcc agggatgaag ctgaaatgga atatctgaag atagctcagg 1080
acctggagat gtacggtgtg aactactttg caatccggaa taaaaagggc acagagctgc 1140
tgcttggagt ggatgccctg gggcttcaca tttatgaccc tgagaacaga ctgaccccca 1200
agatctcctt cccgtggaat gaaatccgaa acatctcgta cagtgacaag gagtttacta 1260
ttaaaccact ggataagaaa attgatgtct tcaagtttaa ctcctcaaag cttcgtgtta 1320
ataagctgat tctccagcta tgtatcggga accatgatct atttatgagg agaaggaaag 1380
ccgattcttt ggaagttcag cagatgaaag cccaggccag ggaggagaag gctagaaagc 1440
agatggagcg gcagcgcctc gctcgagaga agcagatgag ggaggaggct gaacgcacga 1500
gggatgagtt ggagaggagg ctgctgcaga tgaaagaaga agcaacaatg gccaacgaag 1560
cactgatgcg gtctgaggag acagctgacc tgttggctga aaaggcccag atcaccgagg 1620
aggaggcaaa acttctggcc cagaaggccg cagaggctga gcaggaaatg cagcgcatca 1680
aggccacagc gattcgcacg gaggaggaga agcgcctgat ggagcagaag gtgctggaag 1740
ccgaggtgct ggcactgaag atggctgagg agtcagagag gagggccaaa gaggcagatc 1800
agctgaagca ggacctgcag gaagcacgcg aggcggagcg aagagccaag cagaagctcc 1860
tggagattgc caccaagccc acgtacccgc ccatgaaccc aattccagca ccgttgcctc 1920
ctgacatacc aagcttcaac ctcattggtg acagcctgtc tttcgacttc aaagatactg 1980
acatgaagcg gctttccatg gagatagaga aagaaaaagt ggaatacatg gaaaagagca 2040
agcatctgca ggagcagctc aatgaactca agacagaaat cgaggccttg aaactgaaag 2100
agagggagac agctctggat attctgcaca atgagaactc cgacaggggt ggcagcagca 2160
agcacaatac cattaaaaag ctcaccttgc agagcgccaa gtcccgagtg gccttctttg 2220
aagagctcta gcaggtgacc cagccacccc aggacctgcc acttctcctg ctaccgggac 2280
cgcgggatgg accagatatc aagagagcca tccataggga gctggctggg ggtttccgtg 2340
ggagctccag aactttcccc agctgagtga agagcccagc ccctcttatg tgcaattgcc 2400
ttgaactacg accctgtaga gatttctctc atggcgttct agttctctga cctgagtctt 2460
tgttttaaga agtatttgtc ttcctttgtc taatgtggga ttcctgactc ccttcgtcca 2520
aggcaccggt gtgtgtgtgt cttgcactcc agagctgacc tccaccgccc agcctgggaa 2580
gtcattgtag ggagtgagac actgaagccc tgagaagcca gtgccatcat ccccaccccg 2640
cccagggttc cggaacattc attcccccac cggtgaggac ctggcatgca gcgaagcagc 2700
ccagcccggc ggatcccagg ccagcacgcc tgccggcttc tcatcgtcag ggagcccgcc 2760
cagagctcgt gacgagcaag tgctgggtcc ccgccaggca ccccgaggcg gcgctctggc 2820
tggcagctgg tggggaatag gcagggcagc tgtggctggg gagagacttt aggcagaagc 2880
tgtgatgcag gctgactgcc agccgagggg ctgggtagtg ccgtgcggga gctgatggta 2940
cagggcactc gctgtccccc tccggccacc ctagaccagg gtccgagagg caggcaggag 3000
ccactcatgt cttccccatt gcccgacgcc catagacgct ccttcctgtg tggggctggg 3060
gtactccctg gtcgtactgc agtcagcacc cgtaacccgg ctatgaccag ggatctgtaa 3120
gccctgtggc tccacaggtg ctgcttctca ctggcccaga ctctgagctc caccggccca 3180
gtctgcacgg cccatctgct tcaccttccc tcccagccac gtgccagtgg ccacagccca 3240
cttcccaacc cactgttgta cccaggcctc actttgctgt tgcccttgtc cctcttcggg 3300
ccctgaattt tctgttccct gggggccagc cagggccctt tgtgcccctc ccagcacagg 3360
cctgatgcag gtgtccactc acaggtggcg ctcacctagg ctgtcacagg acccacctcc 3420
atgccaggca acagagggcc acagaaccac ccccacggct cactccttgg tctggggcca 3480
ccttcttgcc ctttcttttt tttttttttt ttttttttcc gagatggagt ctctctctgt 3540
cacccaggtg ggagtgtggt ggcacaatct cggctcactg caacctccac ctcctgagtt 3600
caagcaattc tcctgcctca gcctcccaag tagctgggac tacaggcatg caccaccaca 3660
cttggccaat gttctgtatt tttaataggg acggggtttt gccatgttag ctaggctggt 3720
ctcaaactca cacctgggat tacaggcatg agccactgca cccagcccct tcttgccctt 3780
tcttttctcc atggctgatg ctgctgtggc cagccagggc ccttgagatc cttccagttt 3840
ggctgttatg caaagcaggt gatttgtctt aatcagataa aagatagagg ctatgggggc 3900
ctcaagattt ttggagagca gaggtggtct ctggcaattc catctggttt tgagaaactt 3960
agcagctcac agagcacaga gatcctgcct tcttcctact atcaggctga cctaatgggg 4020
ttgggctgct cggcaactgc ttgggtcacc ttgccccaag gaaaccagcc ctgggtgcca 4080
cccagccact tagggtctac agggtgggac tccagaccta gagcgtaagt atggatgttg 4140
tggccctgtg tcttcctagt gtgacccagc caggagcgga agcttcaggc gtttgtaaag 4200
tgaggtctgg ctctgcctcc tccgtttttt ttttttttct gtttctgttt ctgttttttt 4260
tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtgtcacga tctcagctca 4320
ctgcaacctc cgcctcccag gtacaagaga ttctcctgcc tcagcctccc gagtagctgg 4380
gactacaggc gtgtgccacc atgcctggct aatttttgta tttttagtag agatggggtt 4440
tcgccatgtt agccagactg gtctcgaact cctgacctca ggtgatcctc ccaccccggc 4500
ttcccaaagt tctgggatta taggcgtgag ccaccatgcc cggtctcttc tcagtcttga 4560
agcccatccc tggatttcca ccaggagtta ctttcctcct gacctgtaaa tttgttcttt 4620
aacaatggct gcaggtggga gcatatggtg gtttataaaa acgctgtcgg gctttgtttc 4680
cttctttagc tgccgtgtct acttctgaag tctgggaagt gccaagccac gcggcctcaa 4740
gggagctggc tggtgtttga gctgtggcag aagcacctgg ggctccaggg agcaggctgg 4800
gaactgcagg accttgctca gccaggagca cttccccctc cttgaggcag gaatactgag 4860
gtgcctcccc acagatggag aaggtggaga ggaggatggg cctcaggagc atctcaagcc 4920
ccagtagcag gagaaagaaa gaaagagatg cctggttttc acagactggt tcctgtggct 4980
gggatgactg catccttttt tttttttttt tgagacggag tttttgcctt tgtcgcccag 5040
gctggagtgc aatggcgtga tctcggctca ccgcaacctc cgcctcccgg attcaagcaa 5100
ttctcctgcc tcagcctccc gagtagctgg gattacaggc acgcacctcc acgtccggct 5160
aattttgtat ttttagtgga gacggggttt ctccatgtcg gtcaggctgg tctcgaactc 5220
ccgacctcag gtgatctgcc cacctcggcc tcccaaagtg ctgggattac aggcatgagc 5280
caccgcgctt ggccagactg cgtccttttt aagcgaacat tttagggcct gggagtttgt 5340
caagtaagga agtctcaagc ccaaagagca gcgtcctgac catggtggtt tcattacgag 5400
cccttctgct ggctctcagg cagaagcccc acagcaccgg gaccattcat gaggtcactg 5460
cccagctcat gatgtccgtg aggctgtcct tttggccagt agccgtgtgc agctgtgtgg 5520
cacagatggc ttcgttcatc ctgatcaagg ccccacctca gccacagcag tccccccaac 5580
ctgtgttgtc caccctatta ttcatgtacc tgccaggccc tgctagatag caccccgtgg 5640
cattacataa cacttcatga gtggctgtgt cttgtaattt tggggacagg tttctctctt 5700
tccctctctt ttttttgtca aaagcccaga gactgacaac cagctgcagt gtctaagtgt 5760
tcctcactga cagggtgggg cctcaccacc cctggaggga gcagcgttgg cagggagaca 5820
gcctggccca gtgaccctgg gcccaagcca gcccctccag ggctttcagg gaagcgccat 5880
ccattttcaa agatgtcaaa cgtcacttct tcctgtaggg cccgagtcct gcctcctatc 5940
agggccagat catagaaggc tattttctat tctggggaac gattataact taaatgattg 6000
ttttaataaa aattctaagc tggaaaataa aaaaaaaaaa aaaaaa                6046



<210> 76
<211> 595
<212> PRT
<213> Homo Sapiens

<220> 
<221> PEPTIDE        
<222> (1)...(595)
<223> Merlin protein

<400> 76
Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg
 1               5                  10                  15      
Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu
            20                  25                  30          
Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp
        35                  40                  45              
Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu
    50                  55                  60                  
Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys
65                  70                  75                  80  
Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe
                85                  90                  95      
Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu
            100                 105                 110         
Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp
        115                 120                 125             
Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr
    130                 135                 140                 
Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg
145                 150                 155                 160 
Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu
                165                 170                 175     
Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr
            180                 185                 190         
Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu
        195                 200                 205             
Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile
    210                 215                 220                 
Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly
225                 230                 235                 240 
Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe
                245                 250                 255     
Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr
            260                 265                 270         
Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser
        275                 280                 285             
Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His
    290                 295                 300                 
Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln
305                 310                 315                 320 
Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg
                325                 330                 335     
Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr
            340                 345                 350         
Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr
        355                 360                 365             
Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu
    370                 375                 380                 
Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln
385                 390                 395                 400 
Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala
                405                 410                 415     
Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu
            420                 425                 430         
Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala
        435                 440                 445             
Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala
    450                 455                 460                 
Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr
465                 470                 475                 480 
Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro
                485                 490                 495     
Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr
            500                 505                 510         
Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr
        515                 520                 525             
Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr
    530                 535                 540                 
Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile
545                 550                 555                 560 
Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr
                565                 570                 575     
Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe
            580                 585                 590         
Glu Glu Leu
        595 


<210> 77
<211> 1447
<212> DNA
<213> Homo Sapiens

<220> 
<221> prim_transcript
<222> (1)...(1447)
<223> OPN mRNA

<400> 77
gaggcagcag cagcaggagg aggcagacac agcatcgtcg ggaccagact cgtctcaggc 60
cagttgcagc cttctcagcc aaacgccgac caaggaaaac tcactaccat gagaattgca 120
gtgatttgct tttgcctcct aggcatcacc tgtgccatac cagttaaaca ggctgattct 180
ggaagttctg aggaaaagca gctttacaac aaatacccag atgctgtggc cacatggcta 240
aaccctgacc catctcagaa gcagaatctc ctagccccac agacccttcc aagtaagtcc 300
aacgaaagcc atgaccacat ggatgatatg gatgatgaag atgatgatga ccatgtggac 360
agccaggact ccattgactc gaacgactct gatgatgtag atgacactga tgattctcac 420
cagtctgatg agtctcacca ttctgatgaa tctgatgaac tggtcactga ttttcccacg 480
gacctgccag caaccgaagt tttcactcca gttgtcccca cagtagacac atatgatggc 540
cgaggtgata gtgtggttta tggactgagg tcaaaatcta agaagtttcg cagacctgac 600
atccagtacc ctgatgctac agacgaggac atcacctcac acatggaaag cgaggagttg 660
aatggtgcat acaaggccat ccccgttgcc caggacctga acgcgccttc tgattgggac 720
agccgtggga aggacagtta tgaaacgagt cagctggatg accagagtgc tgaaacccac 780
agccacaagc agtccagatt atataagcgg aaagccaatg atgagagcaa tgagcattcc 840
gatgtgattg atagtcagga actttccaaa gtcagccgtg aattccacag ccatgaattt 900
cacagccatg aagatatgct ggttgtagac cccaaaagta aggaagaaga taaacacctg 960
aaatttcgta tttctcatga attagatagt gcatcttctg aggtcaatta aaaggagaaa 1020
aaatacaatt tctcactttg catttagtca aaagaaaaaa tgctttatag caaaatgaaa 1080
gagaacatga aatgcttctt tctcagttta ttggttgaat gtgtatctat ttgagtctgg 1140
aaataactaa tgtgtttgat aattagttta gtttgtggct tcatggaaac tccctgtaaa 1200
ctaaaagctt cagggttatg tctatgttca ttctatagaa gaaatgcaaa ctatcactgt 1260
attttaatat ttgttattct ctcatgaata gaaatttatg tagaagcaaa caaaatactt 1320
ttacccactt aaaaagagaa tataacattt tatgtcacta taatcttttg ttttttaagt 1380
tagtgtatat tttgttgtga ttatcttttt gtggtgtgaa taaatctttt atcttgaatg 1440
taataag                                                           1447

<210> 78
<211> 300
<212> PRT
<213> Homo Sapiens

<220> 
<221> PEPTIDE        
<222> (1)...(300)
<223> OPN protein

<400> 78
Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala
 1               5                  10                  15      
Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu
            20                  25                  30          
Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro
        35                  40                  45              
Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser
    50                  55                  60                  
Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp
65                  70                  75                  80  
Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp
                85                  90                  95      
Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser
            100                 105                 110         
Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala
        115                 120                 125             
Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly
    130                 135                 140                 
Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe
145                 150                 155                 160 
Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr
                165                 170                 175     
Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro
            180                 185                 190         
Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys
        195                 200                 205             
Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His
    210                 215                 220                 
Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser
225                 230                 235                 240 
Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser
                245                 250                 255     
Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val
            260                 265                 270         
Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile
        275                 280                 285             
Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn
    290                 295                 300 

