                         SEQUENCE LISTING

<110>  Technische Universitt Dresden
 
<120>  Anti-La Antikrper und ihre Anwendung zum Immunotargeting

<130>  00017P0140DEWO

<150>  DE 10 2010 039 018.6-41
<151>  2010-08-06

<160>  85    

<170>  PatentIn version 3.5

<210>  1
<211>  408
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Glu Asn Gly Asp Asn Glu Lys Met Ala Ala Leu Glu Ala Lys 
1               5                   10                  15      


Ile Cys His Gln Ile Glu Tyr Tyr Phe Gly Asp Phe Asn Leu Pro Arg 
            20                  25                  30          


Asp Lys Phe Leu Lys Glu Gln Ile Lys Leu Asp Glu Gly Trp Val Pro 
        35                  40                  45              


Leu Glu Ile Met Ile Lys Phe Asn Arg Leu Asn Arg Leu Thr Thr Asp 
    50                  55                  60                  


Phe Asn Val Ile Val Glu Ala Leu Ser Lys Ser Lys Ala Glu Leu Met 
65                  70                  75                  80  


Glu Ile Ser Glu Asp Lys Thr Lys Ile Arg Arg Ser Pro Ser Lys Pro 
                85                  90                  95      


Leu Pro Glu Val Thr Asp Glu Tyr Lys Asn Asp Val Lys Asn Arg Ser 
            100                 105                 110         


Val Tyr Ile Lys Gly Phe Pro Thr Asp Ala Thr Leu Asp Asp Ile Lys 
        115                 120                 125             


Glu Trp Leu Glu Asp Lys Gly Gln Val Leu Asn Ile Gln Met Arg Arg 
    130                 135                 140                 


Thr Leu His Lys Ala Phe Lys Gly Ser Ile Phe Val Val Phe Asp Ser 
145                 150                 155                 160 


Ile Glu Ser Ala Lys Lys Phe Val Glu Thr Pro Gly Gln Lys Tyr Lys 
                165                 170                 175     


Glu Thr Asp Leu Leu Ile Leu Phe Lys Asp Asp Tyr Phe Ala Lys Lys 
            180                 185                 190         


Asn Glu Glu Arg Lys Gln Asn Lys Val Glu Ala Lys Leu Arg Ala Lys 
        195                 200                 205             


Gln Glu Gln Glu Ala Lys Gln Lys Leu Glu Glu Asp Ala Glu Met Lys 
    210                 215                 220                 


Ser Leu Glu Glu Lys Ile Gly Cys Leu Leu Lys Phe Ser Gly Asp Leu 
225                 230                 235                 240 


Asp Asp Gln Thr Cys Arg Glu Asp Leu His Ile Leu Phe Ser Asn His 
                245                 250                 255     


Gly Glu Ile Lys Trp Ile Asp Phe Val Arg Gly Ala Lys Glu Gly Ile 
            260                 265                 270         


Ile Leu Phe Lys Glu Lys Ala Lys Glu Ala Leu Gly Lys Ala Lys Asp 
        275                 280                 285             


Ala Asn Asn Gly Asn Leu Gln Leu Arg Asn Lys Glu Val Thr Trp Glu 
    290                 295                 300                 


Val Leu Glu Gly Glu Val Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu 
305                 310                 315                 320 


Asp Gln Gln Glu Ser Leu Asn Lys Trp Lys Ser Lys Gly Arg Arg Phe 
                325                 330                 335     


Lys Gly Lys Gly Lys Gly Asn Lys Ala Ala Gln Pro Gly Ser Gly Lys 
            340                 345                 350         


Gly Lys Val Gln Phe Gln Gly Lys Lys Thr Lys Phe Ala Ser Asp Asp 
        355                 360                 365             


Glu His Asp Glu His Asp Glu Asn Gly Ala Thr Gly Pro Val Lys Arg 
    370                 375                 380                 


Ala Arg Glu Glu Thr Asp Lys Glu Glu Pro Ala Ser Lys Gln Gln Lys 
385                 390                 395                 400 


Thr Glu Asn Gly Ala Gly Asp Gln 
                405             


<210>  2
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  2

Ser Lys Gly Arg Arg Phe Lys Gly Lys Gly Lys Gly Asn 
1               5                   10              


<210>  3
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  3

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Pro Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

His Tyr Tyr Ile Tyr 
1               5   


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Trp Ala Ser Thr Arg Lys Ser 
1               5           


<210>  6
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  6

Gly Val Asn Pro Ser Asn Gly Gly Thr His Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  7
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  7

Lys Gln Ser Tyr Asn Leu Leu Thr 
1               5               


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  8

Ser Glu Tyr Asp Tyr Gly Leu Gly Phe Ala Tyr 
1               5                   10      


<210>  9
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  9

Arg Ser Ser Gln Ser Leu Leu Asp Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  10
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Phe Trp Met Asn 
1               5   


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Ile Arg Asn Lys Pro Asn Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
1               5                   10                  15      


Leu Lys Gly 
            


<210>  13
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  13

Lys Gln Ser Tyr Asn Leu Pro Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  14

Leu Gly Asn Ser Trp Phe Ala Tyr 
1               5               


<210>  15
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  15

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  16
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  16

Asn Tyr Tyr Ile Tyr 
1               5   


<210>  17
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  18
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  18

Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Gln Trp Ser Ser Asn Pro Gln 
1               5               


<210>  20
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  20

Arg Gly Ala Leu Gly Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  21

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  22
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  22

Asn Tyr Gly Ile Ser 
1               5   


<210>  23
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  23

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  24

Glu Ile Tyr Arg Gly Ser Gly Asn Ser Tyr Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Gln Gln Trp Ile Ser Asn Pro Pro Thr 
1               5                   


<210>  26
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  26

Gly Gly Leu Ser Phe Ala Tyr 
1               5           


<210>  27
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  27

Arg Ala Ser Glu Asn Ile Tyr Thr Tyr Leu Ala 
1               5                   10      


<210>  28
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  28

Asp Tyr Trp Ile Glu 
1               5   


<210>  29
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  29

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  30
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  30

Glu Ile Leu Pro Gly Ser Val Ser Ile Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  31

Gln His His Tyr Gly Thr Pro Tyr Thr 
1               5                   


<210>  32
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  32

Ser Arg Ser Ile Tyr Asp Gly Tyr Phe Tyr Tyr 
1               5                   10      


<210>  33
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  33

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  34
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  34

Ser Tyr Gly Ile Asn 
1               5   


<210>  35
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  35

Arg Thr Ser Asn Leu Glu Ser 
1               5           


<210>  36
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  36

Glu Ile Tyr Pro Gly Ser Gly Thr Thr Phe Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  37
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  37

Gln Gln Tyr His Ser Tyr Pro Arg Thr 
1               5                   


<210>  38
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  38

His Gly Gly Tyr Pro Phe Tyr Phe Asp Tyr 
1               5                   10  


<210>  39
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  39

Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  40
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  40

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  41

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  42
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  42

His Ile Tyr Trp Asp Asp Asp Lys Gly Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  43
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  43

Gln Gln Ser Asn Glu Asp Pro Pro Thr 
1               5                   


<210>  44
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  44

Gly Asp Val Glu Phe Asp Tyr 
1               5           


<210>  45
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  45

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  46
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  46

Thr Tyr Gly Leu Thr 
1               5   


<210>  47
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  47

Arg Thr Ser Asn Leu Glu Ser 
1               5           


<210>  48
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  48

Glu Ile Phe Pro Gly Ser Gly Thr Thr Phe Tyr Asn Glu Lys Phe Asn 
1               5                   10                  15      


Asp 
    


<210>  49
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  49

Gln Gln Tyr His Ser Tyr Pro Arg Thr 
1               5                   


<210>  50
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  50

Tyr Ser Asn Tyr Pro Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  51
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  51

Ile Val Leu Thr Gln Thr Thr Ser Ser Leu Ala Val Ser Ala Gly Glu 
1               5                   10                  15      


Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg 
            20                  25                  30          


Thr Pro Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Lys Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln Ser 
                85                  90                  95      


Tyr Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 110         


<210>  52
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  52

Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr His Tyr Tyr 
            20                  25                  30          


Ile Tyr Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Gly Val Asn Pro Ser Asn Gly Gly Thr His Phe Asn Glu Lys Phe Lys 
    50                  55                  60                  


Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Ser Glu Tyr Asp Tyr Gly Leu Gly Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  53
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  53

Asp Ile Val Ile Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110     


<210>  54
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  54

Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Pro 
1               5                   10                  15      


Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Phe Trp 
            20                  25                  30          


Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Gln Ile Arg Asn Lys Pro Asn Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser 
    50                  55                  60                  


Leu Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Asn Leu Arg Pro Glu Asp Met Gly Ile Tyr Tyr 
                85                  90                  95      


Cys Thr Leu Gly Asn Ser Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser 
        115     


<210>  55
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  55

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Gln Phe 
                85                  90                  95      


Gly Thr Gly Thr Lys Leu Glu Val Lys Arg 
            100                 105     


<210>  56
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  56

Gln Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Pro Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Tyr Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Asn Pro Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Arg Gly Ala Leu Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  57
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  57

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  58
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  58

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Tyr Arg Gly Ser Gly Asn Ser Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  59
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  59

Asp Ile Val Met Thr Gln Ser Thr Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Tyr Thr Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Arg Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  60
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  60

Gln Val Lys Leu Gln Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Phe Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Glu Trp Leu Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Val Ser Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Arg Ser Ile Tyr Asp Gly Tyr Phe Tyr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  61

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  62
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  62

Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Arg Ser Tyr Gly 
            20                  25                  30          


Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Glu Ile Tyr Pro Gly Ser Gly Thr Thr Phe Tyr Asn Glu Lys Phe Arg 
    50                  55                  60                  


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg His Gly Gly Tyr Pro Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  63
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  63

Asp Ile Val Leu Thr Gln Ser Thr Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  64
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  64

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Gly Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Asp Val Glu Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  65
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  65

Gln Ile Val Leu Thr Gln Ser Pro Thr Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Arg Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  66
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  66

Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr Gly 
            20                  25                  30          


Leu Thr Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Glu Ile Phe Pro Gly Ser Gly Thr Thr Phe Tyr Asn Glu Lys Phe Asn 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Tyr Ser Asn Tyr Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  67
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  67
attgtgctga cacagactac atcctccctg gctgtgtcag caggagagaa ggtcactatg       60

agctgcaaat ccagtcagag tctgctcaac agtagaaccc caaagaacta cttggcttgg      120

taccagcaga aaccagggca gtctcctaaa ctgctgatct actgggcatc cactaggaaa      180

tctggggtcc ctgatcgctt cacaggcagt ggatctggga cagatttcac tctcaccatc      240

agcagtgtgc aggctgaaga cctggcagtt tattactgca agcaatctta taatctgctc      300

acgttcggtg ctgggaccaa gctggagctg aaacgg                                336


<210>  68
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  68
gtccagctgg aggagtcagg ggctgaactg gtgaagcctg gggcttcagt gaaattgtcc       60

tgcaaggctt ctggctacgc cttcacccac tactatatat actggataaa acagaggcct      120

ggacaaggcc ttgagtggat tgggggggtt aatcctagca atggtggtac tcacttcaat      180

gagaagttca agagcaaggc cacactgact gtagacaaat cctccagtac agcctacatg      240

caactcagca gcctgacatc tgaggactct gcggtctatt attgtacaag atcggagtat      300

gattacggat tggggtttgc ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  69
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  69
gacattgtga tcacacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact       60

atgagctgca gatccagtca gagtctgctc gacagtagaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcaatg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt      300

ccgacgttcg gtggaggcac caagctggaa atcaaacgg                             339


<210>  70
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  70
gttaagctgc aggagtcagg aggaggcttg gtgcaacctg ggaggcccat gaaactctcc       60

tgtgttgcct ctggattcac ttttagtgac ttctggatga actgggtccg ccagtctcca      120

gagaaaggac tggagtgggt agcacaaatt agaaacaaac ctaataatta tgaaacgtat      180

tattcagatt ctttgaaagg cagattcacc atctcaagag atgattccaa aagtagtgtc      240

tacctgcaaa tgaacaactt aagacctgaa gacatgggta tctattactg tacactaggt      300

aactcctggt ttgcttactg gggccaaggg actctggtca ctgtctct                   348


<210>  71
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  71
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatgtatt ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgt      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtagtaacc cacagttcgg tactgggacc      300

aagctggagg tgaaacgg                                                    318


<210>  72
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  72
caggtaaagc tggaggagtc aggacctgag ctggtgaagc ctggggctcc agtgaagata       60

tcctgcaaga cttctggcta caccttcact aactactata tatattgggt gaaacagagg      120

cctggacagg gcctagagtg gattggatat atttatcctg gaaatggtgg tactgcctac      180

aatcagaaat ttaaggacaa ggccacactg actgcagaca atccctccaa cactgcctac      240

atgcagctca gtagcctgac ctctgaggac tctgcggtct atctctgtgc aagaagaggg      300

gctttaggat actactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  73
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  73
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaact tacatgcact ggtaccagca gaagtcaggc      120

acctccccca aaagatggat ttatgacaca tccaaactgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcaccat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg attagtaacc cacccacgtt cggagggggg      300

accaagctgg aaataaaacg g                                                321


<210>  74
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  74
caggttcagc tgcagcagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata ttccctcaca aactatggta taagttgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttatcgtg gaagtggtaa tagttactac      180

aatgagaagt tcaagggcaa ggcctcactg actgcagaca aatcctccag cacagcctac      240

atgcagctca gcagcctgac atctgaggac tctgccgtct atttctgtgc aagagggggg      300

ctatcctttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  75
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  75
gatattgtga tgacccagtc tacagcctcc ctatctgcat ctgtgggaga aactgtcacc       60

atcacatgtc gagcaagtga gaatatttac acttatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctataat gcaaaaacct tagcagaagg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga ggatcaacag cctgcagcct      240

gaagattttg ggagttatta ctgtcaacat cattatggta ccccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acgg                                             324


<210>  76
<211>  360
<212>  DNA
<213>  Mus musculus

<400>  76
caggtcaagc tgcaggagtc aggagctgag ctgatgaagc ctgggtcctc agtgaagttt       60

tcctgcaagg ctgctggcta cacattcact gactattgga tagagtggtt aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtgttag tattaagtac      180

aatgagaagt tcaagggcaa ggccacattc actgcagata catcctccaa cacagcctac      240

atgcaactca gcagcctgac atctgaggat tctgcggtct attactgtgc aagatcaagg      300

tctatctatg atggttactt ttattactgg ggccaaggca ccactctcac agtctcctca      360


<210>  77
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  77
gatattgtga tgacacagtc tccagcaatc atgtctgcat ctcctgggga gaaggtcacc       60

atttcctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatcgcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtat catagttacc cacggacgtt cggtggaggc      300

accaagctgg aaatcaaacg g                                                321


<210>  78
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  78
gaggtgcagc tgcaggagtc tggagctgag ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata cagcttcaga agctatggta taaactgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttatcctg gaagtggtac tactttctac      180

aatgagaagt tcaggggcaa ggccacactg actgcagaca agtcctccag cacagcctac      240

atgcagctca aaagcctgac atctgaggac tctgccgtct atttctgtgc aagacatggt      300

ggttacccgt tctactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  79
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  79
gatattgtgc tgacccaatc tacagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gagccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc gtgcatccaa cctagaatct      180

gggatccctg ccaggttcag tggcagtggg tctaggacag acttcaccct caccattaat      240

cctgtggagg ctgatgatgt tgcaacctac tactgtcagc aaagtaatga ggatcctccc      300

acgttcggct cggggacaaa gttggaaata aaacgg                                336


<210>  80
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  80
gaagtgcagc tgcaggagtc aggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagggc      180

tataacccat ccctgaagag ccggctcaca atctccaagg atacctccag aaaccaggta      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactactg tgctcgaggg      300

gacgtcgagt ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  81
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  81
caaattgttc tcacccagtc tccaacaatc atgtctgcat ctccagggga gaaggtcacc       60

atatcctgca gtgccagctc aagtgtaagt tacatgtact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatcgcaca tccaacctgg cttctggagt ccctgatcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtat catagttacc cacggacgtt cggtggaggc      300

accaagctgg aaatcaaacg g                                                321


<210>  82
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  82
gaagtgcagc tgcagcagtc aggagctgaa ctggcgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggata caccttcaca acctatggtt taacctgggt gaagcagaga      120

actggacagg gccttgagtg gattggagag atttttcctg gaagtggtac tactttctac      180

aatgagaagt tcaacgacaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcagctca ccagcctgac atctgaggac tctgccgtct atttctgtgc aagatatagt      300

aactacccgt actactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  83
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  83

Lys Pro Leu Pro Glu Val Thr Asp Glu Tyr 
1               5                   10  


<210>  84
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ser Leu 
1               5                   10                  15      


Asn Lys 
        


<210>  85
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Linker peptide

<400>  85

Glu Lys Glu Ala Leu Lys Lys Ile Ile Glu Asp Gln Gln Glu Ser Leu 
1               5                   10                  15      


Asn Lys 
        


