                         SEQUENCE LISTING

<110>  TransMIT Gesellschaft fr Technologietransfer mbH
 
<120>  Invention related to soluble Toll-like receptor (TLR) derived 
       peptides and proteins

<130>  TM 499

<140>  EP10171663.7
<141>  2010-08-02

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2565
<212>  DNA
<213>  human


<220>
<221>  Ig Kappa IgG
<222>  (1)..(63)

<220>
<221>  HA-tag
<222>  (64)..(90)

<220>
<221>  Q628 stop-codon mutationsite
<222>  (1921)..(1923)

<300>
<301>  Hajjar et al.
<303>  Nat. immunol.
<304>  3
<305>  4
<306>  354-359
<307>  2002-04-01
<313>  (1)..(2565)

<400>  1
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gactatccat atgatgttcc agattatgct ggggcccagc cggccagatc tcccggggag      120

ccctgcgtgg aggtggttcc taatattact tatcaatgca tggagctgaa tttctacaaa      180

atccccgaca acctcccctt ctcaaccaag aacctggacc tgagctttaa tcccctgagg      240

catttaggca gctatagctt cttcagtttc ccagaactgc aggtgctgga tttatccagg      300

tgtgaaatcc agacaattga agatggggca tatcagagcc taagccacct ctctacctta      360

atattgacag gaaaccccat ccagagttta gccctgggag ccttttctgg actatcaagt      420

ttacagaagc tggtggctgt ggagacaaat ctagcatctc tagagaactt ccccattgga      480

catctcaaaa ctttgaaaga acttaatgtg gctcacaatc ttatccaatc tttcaaatta      540

cctgagtatt tttctaatct gaccaatcta gagcacttgg acctttccag caacaagatt      600

caaagtattt attgcacaga cttgcgggtt ctacatcaaa tgcccctact caatctctct      660

ttagacctgt ccctgaaccc tatgaacttt atccaaccag gtgcatttaa agaaattagg      720

cttcataagc tgactttaag aaataatttt gatagtttaa atgtaatgaa aacttgtatt      780

caaggtctgg ctggtttaga agtccatcgt ttggttctgg gagaatttag aaatgaagga      840

aacttggaaa agtttgacaa atctgctcta gagggcctgt gcaatttgac cattgaagaa      900

ttccgattag catacttaga ctactacctc gatgatatta ttgacttatt taattgtttg      960

acaaatgttt cttcattttc cctggtgagt gtgactattg aaagggtaaa agacttttct     1020

tataatttcg gatggcaaca tttagaatta gttaactgta aatttggaca gtttcccaca     1080

ttgaaactca aatctctcaa aaggcttact ttcacttcca acaaaggtgg gaatgctttt     1140

tcagaagttg atctaccaag ccttgagttt ctagatctca gtagaaatgg cttgagtttc     1200

aaaggttgct gttctcaaag tgattttggg acaaccagcc taaagtattt agatctgagc     1260

ttcaatggtg ttattaccat gagttcaaac ttcttgggct tagaacaact agaacatctg     1320

gatttccagc attccaattt gaaacaaatg agtgagtttt cagtattcct atcactcaga     1380

aacctcattt accttgacat ttctcatact cacaccagag ttgctttcaa tggcatcttc     1440

aatggcttgt ccagtctcga agtcttgaaa atggctggca attctttcca ggaaaacttc     1500

cttccagata tcttcacaga gctgagaaac ttgaccttcc tggacctctc tcagtgtcaa     1560

ctggagcagt tgtctccaac agcatttaac tcactctcca gtcttcaggt actaaatatg     1620

agccacaaca acttcttttc attggatacg tttccttata agtgtctgaa ctccctccag     1680

gttcttgatt acagtctcaa tcacataatg acttccaaaa aacaggaact acagcatttt     1740

ccaagtagtc tagctttctt aaatcttact cagaatgact ttgcttgtac ttgtgaacac     1800

cagagtttcc tgcaatggat caaggaccag aggcagctct tggtggaagt tgaacgaatg     1860

gaatgtgcaa caccttcaga taagcagggc atgcctgtgc tgagtttgaa tatcacctgt     1920

cagatgaata agaccatcat tggtgtgtcg gtcctcagtg tgcttgtagt atctgttgta     1980

gcagttctgg tctataagtt ctattttcac ctgatgcttc ttgctggctg cataaagtat     2040

ggtagaggtg aaaacatcta tgatgccttt gttatctact caagccagga tgaggactgg     2100

gtaaggaatg agctagtaaa gaatttagaa gaaggggtgc ctccatttca gctctgcctt     2160

cactacagag actttattcc cggtgtggcc attgctgcca acatcatcca tgaaggtttc     2220

cataaaagcc gaaaggtgat tgttgtggtg tcccagcact tcatccagag ccgctggtgt     2280

atctttgaat atgagattgc tcagacctgg cagtttctga gcagtcgtgc tggtatcatc     2340

ttcattgtcc tgcagaaggt ggagaagacc ctgctcaggc agcaggtgga gctgtaccgc     2400

cttctcagca ggaacactta cctggagtgg gaggacagtg tcctggggcg gcacatcttc     2460

tggagacgac tcagaaaagc cctgctggat ggtaaatcat ggaatccaga aggaacagtg     2520

ggtacaggat gcaattggca ggaagcaaca tctatctgac cgcgg                     2565


<210>  2
<211>  2565
<212>  DNA
<213>  human


<220>
<221>  Ig Kappa IgG
<222>  (1)..(63)

<220>
<221>  HA-tag
<222>  (64)..(90)

<220>
<221>  Q628 stop codon
<222>  (1921)..(1923)

<400>  2
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gactatccat atgatgttcc agattatgct ggggcccagc cggccagatc tcccggggag      120

ccctgcgtgg aggtggttcc taatattact tatcaatgca tggagctgaa tttctacaaa      180

atccccgaca acctcccctt ctcaaccaag aacctggacc tgagctttaa tcccctgagg      240

catttaggca gctatagctt cttcagtttc ccagaactgc aggtgctgga tttatccagg      300

tgtgaaatcc agacaattga agatggggca tatcagagcc taagccacct ctctacctta      360

atattgacag gaaaccccat ccagagttta gccctgggag ccttttctgg actatcaagt      420

ttacagaagc tggtggctgt ggagacaaat ctagcatctc tagagaactt ccccattgga      480

catctcaaaa ctttgaaaga acttaatgtg gctcacaatc ttatccaatc tttcaaatta      540

cctgagtatt tttctaatct gaccaatcta gagcacttgg acctttccag caacaagatt      600

caaagtattt attgcacaga cttgcgggtt ctacatcaaa tgcccctact caatctctct      660

ttagacctgt ccctgaaccc tatgaacttt atccaaccag gtgcatttaa agaaattagg      720

cttcataagc tgactttaag aaataatttt gatagtttaa atgtaatgaa aacttgtatt      780

caaggtctgg ctggtttaga agtccatcgt ttggttctgg gagaatttag aaatgaagga      840

aacttggaaa agtttgacaa atctgctcta gagggcctgt gcaatttgac cattgaagaa      900

ttccgattag catacttaga ctactacctc gatgatatta ttgacttatt taattgtttg      960

acaaatgttt cttcattttc cctggtgagt gtgactattg aaagggtaaa agacttttct     1020

tataatttcg gatggcaaca tttagaatta gttaactgta aatttggaca gtttcccaca     1080

ttgaaactca aatctctcaa aaggcttact ttcacttcca acaaaggtgg gaatgctttt     1140

tcagaagttg atctaccaag ccttgagttt ctagatctca gtagaaatgg cttgagtttc     1200

aaaggttgct gttctcaaag tgattttggg acaaccagcc taaagtattt agatctgagc     1260

ttcaatggtg ttattaccat gagttcaaac ttcttgggct tagaacaact agaacatctg     1320

gatttccagc attccaattt gaaacaaatg agtgagtttt cagtattcct atcactcaga     1380

aacctcattt accttgacat ttctcatact cacaccagag ttgctttcaa tggcatcttc     1440

aatggcttgt ccagtctcga agtcttgaaa atggctggca attctttcca ggaaaacttc     1500

cttccagata tcttcacaga gctgagaaac ttgaccttcc tggacctctc tcagtgtcaa     1560

ctggagcagt tgtctccaac agcatttaac tcactctcca gtcttcaggt actaaatatg     1620

agccacaaca acttcttttc attggatacg tttccttata agtgtctgaa ctccctccag     1680

gttcttgatt acagtctcaa tcacataatg acttccaaaa aacaggaact acagcatttt     1740

ccaagtagtc tagctttctt aaatcttact cagaatgact ttgcttgtac ttgtgaacac     1800

cagagtttcc tgcaatggat caaggaccag aggcagctct tggtggaagt tgaacgaatg     1860

gaatgtgcaa caccttcaga taagcagggc atgcctgtgc tgagtttgaa tatcacctgt     1920

tagatgaata agaccatcat tggtgtgtcg gtcctcagtg tgcttgtagt atctgttgta     1980

gcagttctgg tctataagtt ctattttcac ctgatgcttc ttgctggctg cataaagtat     2040

ggtagaggtg aaaacatcta tgatgccttt gttatctact caagccagga tgaggactgg     2100

gtaaggaatg agctagtaaa gaatttagaa gaaggggtgc ctccatttca gctctgcctt     2160

cactacagag actttattcc cggtgtggcc attgctgcca acatcatcca tgaaggtttc     2220

cataaaagcc gaaaggtgat tgttgtggtg tcccagcact tcatccagag ccgctggtgt     2280

atctttgaat atgagattgc tcagacctgg cagtttctga gcagtcgtgc tggtatcatc     2340

ttcattgtcc tgcagaaggt ggagaagacc ctgctcaggc agcaggtgga gctgtaccgc     2400

cttctcagca ggaacactta cctggagtgg gaggacagtg tcctggggcg gcacatcttc     2460

tggagacgac tcagaaaagc cctgctggat ggtaaatcat ggaatccaga aggaacagtg     2520

ggtacaggat gcaattggca ggaagcaaca tctatctgac cgcgg                     2565


<210>  3
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  3
gtgctgagtt tgaatatcac ctgttagatg aataagacca tcattg                      46


<210>  4
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  4
caatgatggt cttattcatc taacaggtga tattcaaact cagcac                      46


<210>  5
<211>  852
<212>  PRT
<213>  human


<220>
<221>  protein hTLR4 wildtyp
<222>  (1)..(852)

<220>
<221>  Ig Kappa IgG
<222>  (1)..(21)

<220>
<221>  HA-tag
<222>  (22)..(30)

<400>  5

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ala 
            20                  25                  30          


Gln Pro Ala Arg Ser Pro Gly Glu Pro Cys Val Glu Val Val Pro Asn 
        35                  40                  45              


Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp Asn 
    50                  55                  60                  


Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu Arg 
65                  70                  75                  80  


His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu Gln Val Leu 
                85                  90                  95      


Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln 
            100                 105                 110         


Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln 
        115                 120                 125             


Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu 
    130                 135                 140                 


Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly 
145                 150                 155                 160 


His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln 
                165                 170                 175     


Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu His 
            180                 185                 190         


Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp Leu 
        195                 200                 205             


Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser 
    210                 215                 220                 


Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg 
225                 230                 235                 240 


Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met 
                245                 250                 255     


Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His Arg Leu Val 
            260                 265                 270         


Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser 
        275                 280                 285             


Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu Ala 
    290                 295                 300                 


Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys Leu 
305                 310                 315                 320 


Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val 
                325                 330                 335     


Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu Leu Val Asn 
            340                 345                 350         


Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg 
        355                 360                 365             


Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp 
    370                 375                 380                 


Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe 
385                 390                 395                 400 


Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr 
                405                 410                 415     


Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser Asn Phe Leu 
            420                 425                 430         


Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser Asn Leu Lys 
        435                 440                 445             


Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr 
    450                 455                 460                 


Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe 
465                 470                 475                 480 


Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe 
                485                 490                 495     


Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu Thr 
            500                 505                 510         


Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala 
        515                 520                 525             


Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser His Asn Asn 
    530                 535                 540                 


Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln 
545                 550                 555                 560 


Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu 
                565                 570                 575     


Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln Asn 
            580                 585                 590         


Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys 
        595                 600                 605             


Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr 
    610                 615                 620                 


Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys 
625                 630                 635                 640 


Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val 
                645                 650                 655     


Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met 
            660                 665                 670         


Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp 
        675                 680                 685             


Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu 
    690                 695                 700                 


Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu 
705                 710                 715                 720 


His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile 
                725                 730                 735     


His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln 
            740                 745                 750         


His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln 
        755                 760                 765             


Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu 
    770                 775                 780                 


Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg 
785                 790                 795                 800 


Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly 
                805                 810                 815     


Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys 
            820                 825                 830         


Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu 
        835                 840                 845             


Ala Thr Ser Ile 
    850         


<210>  6
<211>  640
<212>  PRT
<213>  human


<220>
<221>  Ig Kappa IgG
<222>  (1)..(21)

<220>
<221>  HA-tag
<222>  (22)..(30)

<400>  6

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ala 
            20                  25                  30          


Gln Pro Ala Arg Ser Pro Gly Glu Pro Cys Val Glu Val Val Pro Asn 
        35                  40                  45              


Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile Pro Asp Asn 
    50                  55                  60                  


Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn Pro Leu Arg 
65                  70                  75                  80  


His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu Gln Val Leu 
                85                  90                  95      


Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly Ala Tyr Gln 
            100                 105                 110         


Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn Pro Ile Gln 
        115                 120                 125             


Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu Gln Lys Leu 
    130                 135                 140                 


Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe Pro Ile Gly 
145                 150                 155                 160 


His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn Leu Ile Gln 
                165                 170                 175     


Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn Leu Glu His 
            180                 185                 190         


Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys Thr Asp Leu 
        195                 200                 205             


Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu Asp Leu Ser 
    210                 215                 220                 


Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys Glu Ile Arg 
225                 230                 235                 240 


Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu Asn Val Met 
                245                 250                 255     


Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His Arg Leu Val 
            260                 265                 270         


Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe Asp Lys Ser 
        275                 280                 285             


Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe Arg Leu Ala 
    290                 295                 300                 


Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe Asn Cys Leu 
305                 310                 315                 320 


Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile Glu Arg Val 
                325                 330                 335     


Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu Leu Val Asn 
            340                 345                 350         


Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser Leu Lys Arg 
        355                 360                 365             


Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser Glu Val Asp 
    370                 375                 380                 


Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly Leu Ser Phe 
385                 390                 395                 400 


Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser Leu Lys Tyr 
                405                 410                 415     


Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser Asn Phe Leu 
            420                 425                 430         


Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser Asn Leu Lys 
        435                 440                 445             


Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn Leu Ile Tyr 
    450                 455                 460                 


Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn Gly Ile Phe 
465                 470                 475                 480 


Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly Asn Ser Phe 
                485                 490                 495     


Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg Asn Leu Thr 
            500                 505                 510         


Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser Pro Thr Ala 
        515                 520                 525             


Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser His Asn Asn 
    530                 535                 540                 


Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn Ser Leu Gln 
545                 550                 555                 560 


Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys Lys Gln Glu 
                565                 570                 575     


Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu Thr Gln Asn 
            580                 585                 590         


Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln Trp Ile Lys 
        595                 600                 605             


Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu Cys Ala Thr 
    610                 615                 620                 


Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn Ile Thr Cys 
625                 630                 635                 640 


<210>  7
<211>  483
<212>  DNA
<213>  human

<400>  7
atgttaccat ttctgttttt ttccaccctg ttttcttcca tatttactga agctcagaag       60

cagtattggg tctgcaactc atccgatgca agtatttcat acacctactg tgataaaatg      120

caatacccaa tttcaattaa tgttaacccc tgtatagaat tgaaaggatc caaaggatta      180

ttgcacattt tctacattcc aaggagagat ttaaagcaat tatatttcaa tctctatata      240

actgtcaaca ccatgaatct tccaaagcgc aaagaagtta tttgccgagg atctgatgac      300

gattactctt tttgcagagc tctgaaggga gagactgtga atacaacaat atcattctcc      360

ttcaagggaa taaaattttc taagggaaaa tacaaatgtg ttgttgaagc tatttctggg      420

agcccagaag aaatgctctt ttgcttggag tttgtcatcc tacaccaacc taattcaaat      480

tag                                                                    483


<210>  8
<211>  160
<212>  PRT
<213>  human

<400>  8

Met Leu Pro Phe Leu Phe Phe Ser Thr Leu Phe Ser Ser Ile Phe Thr 
1               5                   10                  15      


Glu Ala Gln Lys Gln Tyr Trp Val Cys Asn Ser Ser Asp Ala Ser Ile 
            20                  25                  30          


Ser Tyr Thr Tyr Cys Asp Lys Met Gln Tyr Pro Ile Ser Ile Asn Val 
        35                  40                  45              


Asn Pro Cys Ile Glu Leu Lys Gly Ser Lys Gly Leu Leu His Ile Phe 
    50                  55                  60                  


Tyr Ile Pro Arg Arg Asp Leu Lys Gln Leu Tyr Phe Asn Leu Tyr Ile 
65                  70                  75                  80  


Thr Val Asn Thr Met Asn Leu Pro Lys Arg Lys Glu Val Ile Cys Arg 
                85                  90                  95      


Gly Ser Asp Asp Asp Tyr Ser Phe Cys Arg Ala Leu Lys Gly Glu Thr 
            100                 105                 110         


Val Asn Thr Thr Ile Ser Phe Ser Phe Lys Gly Ile Lys Phe Ser Lys 
        115                 120                 125             


Gly Lys Tyr Lys Cys Val Val Glu Ala Ile Ser Gly Ser Pro Glu Glu 
    130                 135                 140                 


Met Leu Phe Cys Leu Glu Phe Val Ile Leu His Gln Pro Asn Ser Asn 
145                 150                 155                 160 


