                         SEQUENCE LISTING

<110>  Kumar-Singh, Rajendra
       Cashman, Siobhan M.
       Sweigard, John Harry
 
<120>  Compositions, methods and kits for modeling, diagnosing, and 
       treating complement disorders

<130>  34724-101

<150>  61/368,931
<151>  2010-07-29

<150>  61/441,501
<151>  2011-02-10

<150>  61/445,430
<151>  2011-02-22

<150>  61/480,082
<151>  2011-04-28

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  1

Met Gly Ile Gln Gly Gly Ser Val Leu Phe Gly Leu Leu Leu Val Leu 
1               5                   10                  15      


Ala Val Phe Cys His Ser Gly His Ser Leu Gln Cys Tyr Asn Cys Pro 
            20                  25                  30          


Asn Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe 
        35                  40                  45              


Asp Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys 
    50                  55                  60                  


Trp Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg 
65                  70                  75                  80  


Glu Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe 
                85                  90                  95      


Asn Glu Gln Leu Glu Gly Gly Gly Gly Gly Cys Glu Glu Pro Pro Thr 
            100                 105                 110         


Phe Glu Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr Tyr Glu Ile 
        115                 120                 125             


Gly Glu Arg Val Asp Tyr Lys Cys Lys Lys Gly Tyr Phe Tyr Ile Pro 
    130                 135                 140                 


Pro Leu Ala Thr His Thr Ile Cys Asp Arg Asn His Thr Trp Leu Pro 
145                 150                 155                 160 


Val Ser Asp Asp Ala Cys Tyr Arg Glu Thr Cys Pro Tyr Ile Arg Asp 
                165                 170                 175     


Pro Leu Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly 
            180                 185                 190         


Tyr Gln Met His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu 
        195                 200                 205             


Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Ile Trp Ser Gly 
    210                 215                 220                 


Lys Pro Pro Ile Cys Glu Lys Val Leu Cys Thr Pro Pro Pro Lys Ile 
225                 230                 235                 240 


Lys Asn Gly Lys His Thr Phe Ser Glu Val Glu Val Phe Glu Tyr Leu 
                245                 250                 255     


Asp Ala Val Thr Tyr Ser Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe 
            260                 265                 270         


Ser Leu Ile Gly Glu Ser Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp 
        275                 280                 285             


Ser Arg Ala Ala Pro Glu Cys Lys Val Val Lys Cys Arg Phe Pro Val 
    290                 295                 300                 


Val Glu Asn Gly Lys Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr 
305                 310                 315                 320 


Lys Ala Thr Val Met Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly 
                325                 330                 335     


Ser Asp Thr Ile Val Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val 
            340                 345                 350         


Pro Lys Cys Leu Lys Val Gly Gly Gly Gly Gly Gly Asp Cys Gly Leu 
        355                 360                 365             


Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser 
    370                 375                 380                 


Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val 
385                 390                 395                 400 


Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln 
                405                 410                 415     


Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr 
            420                 425                 430         


Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr 
        435                 440                 445             


Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg 
    450                 455                 460                 


Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys 
465                 470                 475                 480 


Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro 
                485                 490                 495     


Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe 
            500                 505                 510         


Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly 
        515                 520                 525             


Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser 
    530                 535                 540                 


Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln 
545                 550                 555                 560 


Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg 
                565                 570                 575     


Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu 
            580                 585                 590         


His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly 
        595                 600                 605             


Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro 
    610                 615                 620                 


Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser 
625                 630                 635                 640 


Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln 
                645                 650                 655     


Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu 
            660                 665                 670         


Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr 
        675                 680                 685     


<210>  2
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The sequence has been designed and synthesized

<400>  2
ggaggcggag gtgga                                                        15


<210>  3
<211>  3219
<212>  DNA
<213>  Homo sapiens

<400>  3
tgagttgggg attgttgcgt cccatatctg gacccagaag ggacttccct gctcggctgg       60

ctctcggttt ctctgctttc ctccggagaa ataacagcgt cttccgcgcc gcgcatggag      120

cctcccggcc gccgcgagtg tccctttcct tcctggcgct ttcctgggtt gcttctggcg      180

gccatggtgt tgctgctgta ctccttctcc gatgcctgtg aggagccacc aacatttgaa      240

gctatggagc tcattggtaa accaaaaccc tactatgaga ttggtgaacg agtagattat      300

aagtgtaaaa aaggatactt ctatatacct cctcttgcca cccatactat ttgtgatcgg      360

aatcatacat ggctacctgt ctcagatgac gcctgttata gagaaacatg tccatatata      420

cgggatcctt taaatggcca agcagtccct gcaaatggga cttacgagtt tggttatcag      480

atgcacttta tttgtaatga gggttattac ttaattggtg aagaaattct atattgtgaa      540

cttaaaggat cagtagcaat ttggagcggt aagcccccaa tatgtgaaaa ggttttgtgt      600

acaccacctc caaaaataaa aaatggaaaa cacaccttta gtgaagtaga agtatttgag      660

tatcttgatg cagtaactta tagttgtgat cctgcacctg gaccagatcc attttcactt      720

attggagaga gcacgattta ttgtggtgac aattcagtgt ggagtcgtgc tgctccagag      780

tgtaaagtgg tcaaatgtcg atttccagta gtcgaaaatg gaaaacagat atcaggattt      840

ggaaaaaaat tttactacaa agcaacagtt atgtttgaat gcgataaggg tttttacctc      900

gatggcagcg acacaattgt ctgtgacagt aacagtactt gggatccccc agttccaaag      960

tgtcttaaag tgtcgacttc ttccactaca aaatctccag cgtccagtgc ctcaggtcct     1020

aggcctactt acaagcctcc agtctcaaat tatccaggat atcctaaacc tgaggaagga     1080

atacttgaca gtttggatgt ttgggtcatt gctgtgattg ttattgccat agttgttgga     1140

gttgcagtaa tttgtgttgt cccgtacaga tatcttcaaa ggaggaagaa gaaagggaaa     1200

gcagatggtg gagctgaata tgccacttac cagactaaat caaccactcc agcagagcag     1260

agaggctgaa tagattccac aacctggttt gccagttcat cttttgactc tattaaaatc     1320

ttcaatagtt gttattctgt agtttcactc tcatgagtgc aactgtggct tagctaatat     1380

tgcaatgtgg cttgaatgta ggtagcatcc tttgatgctt ctttgaaact tgtatgaatt     1440

tgggtatgaa cagattgcct gctttccctt aaataacact tagatttatt ggaccagtca     1500

gcacagcatg cctggttgta ttaaagcagg gatatgctgt attttataaa attggcaaaa     1560

ttagagaaat atagttcaca atgaaattat attttctttg taaagaaagt ggcttgaaat     1620

cttttttgtt caaagattaa tgccaactct taagattatt ctttcaccaa ctatagaatg     1680

tattttatat atcgttcatt gtaaaaagcc cttaaaaata tgtgtatact actttggctc     1740

ttgtgcataa aaacaagaac actgaaaatt gggaatatgc acaaacttgg cttctttaac     1800

caagaatatt attggaaaat tctctaaaag ttaatagggt aaattctcta ttttttgtaa     1860

tgtgttcggt gatttcagaa agctagaaag tgtatgtgtg gcatttgttt tcacttttta     1920

aaacatccct aactgatcga atatatcagt aatttcagaa tcagatgcat cctttcataa     1980

gaagtgagag gactctgaca gccataacag gagtgccact tcatggtgcg aagtgaacac     2040

tgtagtcttg ttgttttccc aaagagaact ccgtatgttc tcttaggttg agtaacccac     2100

tctgaattct ggttacatgt gtttttctct ccctccttaa ataaagagag gggttaaaca     2160

tgccctctaa aagtaggtgg ttttgaagag aataaattca tcagataacc tcaagtcaca     2220

tgagaatctt agtccattta cattgccttg gctagtaaaa gccatctatg tatatgtctt     2280

acctcatctc ctaaaaggca gagtacaaag taagccatgt atctcaggaa ggtaacttca     2340

ttttgtctat ttgctgttga ttgtaccaag ggatggaaga agtaaatata gctcaggtag     2400

cactttatac tcaggcagat ctcagccctc tactgagtcc cttagccaag cagtttcttt     2460

caaagaagcc agcaggcgaa aagcagggac tgccactgca tttcatatca cactgttaaa     2520

agttgtgttt tgaaatttta tgtttagttg cacaaattgg gccaaagaaa cattgccttg     2580

aggaagatat gattggaaaa tcaagagtgt agaagaataa atactgtttt actgtccaaa     2640

gacatgttta tagtgctctg taaatgttcc tttcctttgt agtctctggc aagatgcttt     2700

aggaagataa aagtttgagg agaacaaaca ggaattctga attaagcaca gagttgaagt     2760

ttatacccgt ttcacatgct tttcaagaat gtcgcaatta ctaagaagca gataatggtg     2820

ttttttagaa acctaattga agtatattca accaaatact ttaatgtata aaataaatat     2880

tatacaatat acttgtatag cagtttctgc ttcacatttg attttttcaa atttaatatt     2940

tatattagag atctatatat gtataaatat gtattttgtc aaatttgtta cttaaatata     3000

tagagaccag ttttctctgg aagtttgttt aaatgacaga agcgtatatg aattcaagaa     3060

aatttaagct gcaaaaatgt atttgctata aaatgagaag tctcactgat agaggttctt     3120

tattgctcat tttttaaaaa atggactctt gaaatctgtt aaaataaaat tgtacatttg     3180

gagatgtttc aaaaaaaaaa aagaaaaaaa aaaaaaaaa                            3219


<210>  4
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe 
1               5                   10                  15      


Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser 
            20                  25                  30          


Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly 
        35                  40                  45              


Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys 
    50                  55                  60                  


Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys 
65                  70                  75                  80  


Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg 
                85                  90                  95      


Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro 
            100                 105                 110         


Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn 
        115                 120                 125             


Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys 
    130                 135                 140                 


Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val 
145                 150                 155                 160 


Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser 
                165                 170                 175     


Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp 
            180                 185                 190         


Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile 
        195                 200                 205             


Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys 
    210                 215                 220                 


Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser 
225                 230                 235                 240 


Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys 
                245                 250                 255     


Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser 
            260                 265                 270         


Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Ser Thr 
        275                 280                 285             


Ser Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro 
    290                 295                 300                 


Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu 
305                 310                 315                 320 


Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val 
                325                 330                 335     


Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg 
            340                 345                 350         


Tyr Leu Gln Arg Arg Lys Lys Lys Gly Lys Ala Asp Gly Gly Ala Glu 
        355                 360                 365             


Tyr Ala Thr Tyr Gln Thr Lys Ser Thr Thr Pro Ala Glu Gln Arg Gly 
    370                 375                 380                 


<210>  5
<211>  1357
<212>  DNA
<213>  Homo sapiens

<400>  5
gcaactcgct ccggccgctg ggcgtagctg cgactcggcg gagtcccggc ggcgcgtcct       60

tgttctaacc cggcgcgcca tgaccgtcgc gcggccgagc gtgcccgcgg cgctgcccct      120

cctcggggag ctgccccggc tgctgctgct ggtgctgttg tgcctgccgg ccgtgtgggg      180

tgactgtggc cttcccccag atgtacctaa tgcccagcca gctttggaag gccgtacaag      240

ttttcccgag gatactgtaa taacgtacaa atgtgaagaa agctttgtga aaattcctgg      300

cgagaaggac tcagtgatct gccttaaggg cagtcaatgg tcagatattg aagagttctg      360

caatcgtagc tgcgaggtgc caacaaggct aaattctgca tccctcaaac agccttatat      420

cactcagaat tattttccag tcggtactgt tgtggaatat gagtgccgtc caggttacag      480

aagagaacct tctctatcac caaaactaac ttgccttcag aatttaaaat ggtccacagc      540

agtcgaattt tgtaaaaaga aatcatgccc taatccggga gaaatacgaa atggtcagat      600

tgatgtacca ggtggcatat tatttggtgc aaccatctcc ttctcatgta acacagggta      660

caaattattt ggctcgactt ctagtttttg tcttatttca ggcagctctg tccagtggag      720

tgacccgttg ccagagtgca gagaaattta ttgtccagca ccaccacaaa ttgacaatgg      780

aataattcaa ggggaacgtg accattatgg atatagacag tctgtaacgt atgcatgtaa      840

taaaggattc accatgattg gagagcactc tatttattgt actgtgaata atgatgaagg      900

agagtggagt ggcccaccac ctgaatgcag aggaaaatct ctaacttcca aggtcccacc      960

aacagttcag aaacctacca cagtaaatgt tccaactaca gaagtctcac caacttctca     1020

gaaaaccacc acaaaaacca ccacaccaaa tgctcaagca acacggagta cacctgtttc     1080

caggacaacc aagcattttc atgaaacaac cccaaataaa ggaagtggaa ccacttcagg     1140

tactacccgt cttctatctg ggcacacgtg tttcacgttg acaggtttgc ttgggacgct     1200

agtaaccatg ggcttgctga cttagccaaa gaagagttaa gaagaaaata cacacaagta     1260

tacagactgt tcctagtttc ttagacttat ctgcatattg gataaaataa atgcaattgt     1320

gctcttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                              1357


<210>  6
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Val Ala Arg Pro Ser Val Pro Ala Ala Leu Pro Leu Leu Gly 
1               5                   10                  15      


Glu Leu Pro Arg Leu Leu Leu Leu Val Leu Leu Cys Leu Pro Ala Val 
            20                  25                  30          


Trp Gly Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala 
        35                  40                  45              


Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys 
    50                  55                  60                  


Cys Glu Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile 
65                  70                  75                  80  


Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg 
                85                  90                  95      


Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro 
            100                 105                 110         


Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu 
        115                 120                 125             


Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr 
    130                 135                 140                 


Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys 
145                 150                 155                 160 


Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val 
                165                 170                 175     


Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr 
            180                 185                 190         


Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly 
        195                 200                 205             


Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr 
    210                 215                 220                 


Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg 
225                 230                 235                 240 


Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly 
                245                 250                 255     


Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp 
            260                 265                 270         


Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu 
        275                 280                 285             


Thr Ser Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val 
    290                 295                 300                 


Pro Thr Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr 
305                 310                 315                 320 


Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr 
                325                 330                 335     


Thr Lys His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr 
            340                 345                 350         


Ser Gly Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr 
        355                 360                 365             


Gly Leu Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
    370                 375                 380     


<210>  7
<211>  5088
<212>  DNA
<213>  Mus musculus

<400>  7
ctgcccctta ccccttcatt ccttccacct ttttccttca ctatgggacc agcttcaggg       60

tcccagctac tagtgctact gctgctgttg gccagctccc cattagctct ggggatcccc      120

atgtattcca tcattactcc caatgtccta cggctggaga gcgaagagac catcgtactg      180

gaggcccacg atgctcaggg tgacatccca gtcacagtca ctgtgcaaga cttcctaaag      240

aggcaagtgc tgaccagtga gaagacagtg ttgacaggag ccagtggaca tctgagaagc      300

gtctccatca agattccagc cagtaaggaa ttcaactcag ataaggaggg gcacaagtac      360

gtgacagtgg tggcaaactt cggggaaacg gtggtggaga aagcagtgat ggtaagcttc      420

cagagtgggt acctcttcat ccagacagac aagaccatct acacccctgg ctccactgtc      480

ttatatcgga tcttcactgt ggacaacaac ctactgcccg tgggcaagac agtcgtcatc      540

ctcattgaga cccccgatgg cattcctgtc aagagagaca ttctgtcttc caacaaccaa      600

cacggcatct tgcctttgtc ttggaacatt cctgaactgg tcaacatggg gcagtggaag      660

atccgagcct tttacgaaca tgcgccgaag cagatcttct ccgcagagtt tgaggtgaag      720

gaatacgtgc tgcccagttt tgaggtccgg gtggagccca cagagacatt ttattacatc      780

gatgacccaa atggcctgga agtttccatc atagccaagt tcctgtacgg gaaaaacgtg      840

gacgggacag ccttcgtgat ttttggggtc caggatggcg ataagaagat ttctctggcc      900

cactccctca cgcgcgtagt gattgaggat ggtgtggggg atgcagtgct gacccggaag      960

gtgctgatgg agggggtacg gccttccaac gccgacgccc tggtggggaa gtccctgtat     1020

gtctccgtca ctgtcatcct gcactcaggt agtgacatgg tagaggcaga gcgcagtggg     1080

atcccgattg tcacttcccc gtaccagatc cacttcacca agacacccaa attcttcaag     1140

ccagccatgc cctttgacct catggtgttc gtgaccaacc ccgatggctc tccggccagc     1200

aaagtgctgg tggtcactca gggatctaat gcaaaggctc tcacccaaga tgatggcgtg     1260

gccaagctaa gcatcaacac acccaacagc cgccaacccc tgaccatcac agtccgcacc     1320

aagaaggaca ctctcccaga atcacggcag gccaccaaga caatggaggc ccatccctac     1380

agcactatgc acaactccaa caactaccta cacttgtcag tgtcacgaat ggagctcaag     1440

ccgggggaca acctcaatgt caacttccac ctgcgcacag acccaggcca tgaggccaag     1500

atccgatact acacctacct ggttatgaac aaggggaagc tcctgaaggc aggccgccag     1560

gttcgggagc ctggccagga cctggtggtc ttgtccctgc ccatcactcc agagtttatt     1620

ccttcatttc gcctggtggc ttactacacc ctgattggag ctagtggcca gagggaggtg     1680

gtggctgact ctgtgtgggt ggatgtgaag gattcctgta ttggcacgct ggtggtgaag     1740

ggtgacccaa gagataacca tctcgcacct gggcaacaaa cgacactcag gattgaagga     1800

aaccaggggg cccgagtggg gctagtggct gtggacaagg gagtgtttgt gctgaacaag     1860

aagaacaaac tcacacagag caagatctgg gatgtggtag agaaggcaga cattggctgc     1920

accccaggca gtgggaagaa ctatgctggt gtcttcatgg atgcaggcct ggccttcaag     1980

acaagccaag gactgcagac tgaacagaga gcagatcttg agtgcaccaa gccagcagcc     2040

cgccgccgtc gctcagtaca gttgatggaa agaaggatgg acaaagctgg tcagtacact     2100

gacaagggtc ttcggaagtg ttgtgaggat ggtatgcggg atatccctat gagatacagc     2160

tgccagcgcc gggcacgcct catcacccag ggcgagaact gcataaaggc cttcatagac     2220

tgctgcaacc acatcaccaa gctgcgtgaa caacacagaa gagaccacgt gctgggcctg     2280

gccaggagtg aattggagga agacataatt ccagaagaag atattatctc tagaagccac     2340

ttcccacaga gctggttgtg gaccatagaa gagttgaaag aaccagagaa aaatggaatc     2400

tctacgaagg tcatgaacat ctttctcaaa gattccatca ccacctggga gattctggca     2460

gtgagcttgt cagacaagaa agggatctgt gtggcagacc cctatgagat cagagtgatg     2520

caggacttct tcattgacct gcggctgccc tactctgtag tgcgcaacga acaggtggag     2580

atcagagctg tgctcttcaa ctaccgtgaa caggaggaac ttaaggtgag ggtggaactg     2640

ttgcataatc cagccttctg cagcatggcc accgccaaga atcgctactt ccagaccatc     2700

aaaatccctc ccaagtcctc ggtggctgta ccgtatgtca ttgtcccctt gaagatcggc     2760

caacaagagg tggaggtcaa ggctgctgtc ttcaatcact tcatcagtga tggtgtcaag     2820

aagacactga aggtcgtgcc agaaggaatg agaatcaaca aaactgtggc catccataca     2880

ctggacccag agaagctcgg tcaaggggga gtgcagaagg tggatgtgcc tgccgcagac     2940

cttagcgacc aagtgccaga cacagactct gagaccagaa ttatcctgca agggagcccg     3000

gtggttcaga tggctgaaga tgctgtggac ggggagcggc tgaaacacct gatcgtgacc     3060

cccgcaggct gtggggaaca gaacatgatt ggcatgacac caacagtcat tgcggtacac     3120

tacctggacc agaccgaaca gtgggagaag ttcggcatag agaagaggca agaggccctg     3180

gagctcatca agaaagggta cacccagcag ctggccttca aacagcccag ctctgcctat     3240

gctgccttca acaaccggcc ccccagcacc tggctgacag cctacgtggt caaggtcttc     3300

tctctagctg ccaacctcat cgccatcgac tctcacgtcc tgtgtggggc tgttaaatgg     3360

ttgattctgg agaaacagaa gccggatggt gtctttcagg aggatgggcc cgtgattcac     3420

caagaaatga ttggtggctt ccggaacgcc aaggaggcag atgtgtcact cacagccttc     3480

gtcctcatcg cactgcagga agccagggac atctgtgagg ggcaggtcaa tagccttcct     3540

gggagcatca acaaggcagg ggagtatatt gaagccagtt acatgaacct gcagagacca     3600

tacacagtgg ccattgctgg gtatgccctg gccctgatga acaaactgga ggaaccttac     3660

ctcggcaagt ttctgaacac agccaaagat cggaaccgct gggaggagcc tgaccagcag     3720

ctctacaacg tagaggccac atcctacgcc ctcctggccc tgctgctgct gaaagacttt     3780

gactctgtgc cccctgtagt gcgctggctc aatgagcaaa gatactacgg aggcggctat     3840

ggctccaccc aggctacctt catggtattc caagccttgg cccaatatca aacagatgtc     3900

cctgaccata aggacttgaa catggatgtg tccttccacc tccccagccg tagctctgca     3960

accacgtttc gcctgctctg ggaaaatggc aacctcctgc gatcggaaga gaccaagcaa     4020

aatgaggcct tctctctaac agccaaagga aaaggccgag gcacattgtc ggtggtggca     4080

gtgtatcatg ccaaactcaa aagcaaagtc acctgcaaga agtttgacct cagggtcagc     4140

ataagaccag cccctgagac agccaagaag cccgaggaag ccaagaatac catgttcctt     4200

gaaatctgca ccaagtactt gggagatgtg gacgccacta tgtccatcct ggacatctcc     4260

atgatgactg gctttgctcc agacacaaag gacctggaac tgctggcctc tggagtagat     4320

agatacatct ccaagtacga gatgaacaaa gccttctcca acaagaacac cctcatcatc     4380

tacctagaaa agatttcaca caccgaagaa gactgcctga ccttcaaagt tcaccagtac     4440

tttaatgtgg gacttatcca gcccgggtcg gtcaaggtct actcctatta caacctcgag     4500

gaatcatgca cccggttcta tcatccagag aaggacgatg ggatgctcag caagctgtgc     4560

cacagtgaaa tgtgccggtg tgctgaagag aactgcttca tgcaacagtc acaggagaag     4620

atcaacctga atgtccggct agacaaggct tgtgagcccg gagtcgacta tgtgtacaag     4680

accgagctaa ccaacataga gctgttggat gattttgatg agtacaccat gaccatccag     4740

caggtcatca agtcaggctc agatgaggtg caggcagggc agcaacgcaa gttcatcagc     4800

cacatcaagt gcagaaacgc cctgaagctg cagaaaggga agaagtacct catgtggggc     4860

ctctcctctg acctctgggg agaaaagccc aacaccagct acatcattgg gaaggacacg     4920

tgggtggagc actggcctga ggcagaagaa tgccaggatc agaagtacca gaaacagtgc     4980

gaagaacttg gggcattcac agaatctatg gtggtttatg gttgtcccaa ctgactacag     5040

cccagccctc taataaagct tcagttgtat ttcaaaaaaa aaaaaaaa                  5088


<210>  8
<211>  1663
<212>  PRT
<213>  Mus musculus

<400>  8

Met Gly Pro Ala Ser Gly Ser Gln Leu Leu Val Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ala Ser Ser Pro Leu Ala Leu Gly Ile Pro Met Tyr Ser Ile Ile Thr 
            20                  25                  30          


Pro Asn Val Leu Arg Leu Glu Ser Glu Glu Thr Ile Val Leu Glu Ala 
        35                  40                  45              


His Asp Ala Gln Gly Asp Ile Pro Val Thr Val Thr Val Gln Asp Phe 
    50                  55                  60                  


Leu Lys Arg Gln Val Leu Thr Ser Glu Lys Thr Val Leu Thr Gly Ala 
65                  70                  75                  80  


Ser Gly His Leu Arg Ser Val Ser Ile Lys Ile Pro Ala Ser Lys Glu 
                85                  90                  95      


Phe Asn Ser Asp Lys Glu Gly His Lys Tyr Val Thr Val Val Ala Asn 
            100                 105                 110         


Phe Gly Glu Thr Val Val Glu Lys Ala Val Met Val Ser Phe Gln Ser 
        115                 120                 125             


Gly Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser 
    130                 135                 140                 


Thr Val Leu Tyr Arg Ile Phe Thr Val Asp Asn Asn Leu Leu Pro Val 
145                 150                 155                 160 


Gly Lys Thr Val Val Ile Leu Ile Glu Thr Pro Asp Gly Ile Pro Val 
                165                 170                 175     


Lys Arg Asp Ile Leu Ser Ser Asn Asn Gln His Gly Ile Leu Pro Leu 
            180                 185                 190         


Ser Trp Asn Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg 
        195                 200                 205             


Ala Phe Tyr Glu His Ala Pro Lys Gln Ile Phe Ser Ala Glu Phe Glu 
    210                 215                 220                 


Val Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Arg Val Glu Pro Thr 
225                 230                 235                 240 


Glu Thr Phe Tyr Tyr Ile Asp Asp Pro Asn Gly Leu Glu Val Ser Ile 
                245                 250                 255     


Ile Ala Lys Phe Leu Tyr Gly Lys Asn Val Asp Gly Thr Ala Phe Val 
            260                 265                 270         


Ile Phe Gly Val Gln Asp Gly Asp Lys Lys Ile Ser Leu Ala His Ser 
        275                 280                 285             


Leu Thr Arg Val Val Ile Glu Asp Gly Val Gly Asp Ala Val Leu Thr 
    290                 295                 300                 


Arg Lys Val Leu Met Glu Gly Val Arg Pro Ser Asn Ala Asp Ala Leu 
305                 310                 315                 320 


Val Gly Lys Ser Leu Tyr Val Ser Val Thr Val Ile Leu His Ser Gly 
                325                 330                 335     


Ser Asp Met Val Glu Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser 
            340                 345                 350         


Pro Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Phe Phe Lys Pro Ala 
        355                 360                 365             


Met Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro 
    370                 375                 380                 


Ala Ser Lys Val Leu Val Val Thr Gln Gly Ser Asn Ala Lys Ala Leu 
385                 390                 395                 400 


Thr Gln Asp Asp Gly Val Ala Lys Leu Ser Ile Asn Thr Pro Asn Ser 
                405                 410                 415     


Arg Gln Pro Leu Thr Ile Thr Val Arg Thr Lys Lys Asp Thr Leu Pro 
            420                 425                 430         


Glu Ser Arg Gln Ala Thr Lys Thr Met Glu Ala His Pro Tyr Ser Thr 
        435                 440                 445             


Met His Asn Ser Asn Asn Tyr Leu His Leu Ser Val Ser Arg Met Glu 
    450                 455                 460                 


Leu Lys Pro Gly Asp Asn Leu Asn Val Asn Phe His Leu Arg Thr Asp 
465                 470                 475                 480 


Pro Gly His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Val Met Asn 
                485                 490                 495     


Lys Gly Lys Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Ser Leu Pro Ile Thr Pro Glu Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Ile 
545                 550                 555                 560 


Gly Thr Leu Val Val Lys Gly Asp Pro Arg Asp Asn His Leu Ala Pro 
                565                 570                 575     


Gly Gln Gln Thr Thr Leu Arg Ile Glu Gly Asn Gln Gly Ala Arg Val 
            580                 585                 590         


Gly Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys Asn 
        595                 600                 605             


Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp Ile 
    610                 615                 620                 


Gly Cys Thr Pro Gly Ser Gly Lys Asn Tyr Ala Gly Val Phe Met Asp 
625                 630                 635                 640 


Ala Gly Leu Ala Phe Lys Thr Ser Gln Gly Leu Gln Thr Glu Gln Arg 
                645                 650                 655     


Ala Asp Leu Glu Cys Thr Lys Pro Ala Ala Arg Arg Arg Arg Ser Val 
            660                 665                 670         


Gln Leu Met Glu Arg Arg Met Asp Lys Ala Gly Gln Tyr Thr Asp Lys 
        675                 680                 685             


Gly Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Asp Ile Pro Met Arg 
    690                 695                 700                 


Tyr Ser Cys Gln Arg Arg Ala Arg Leu Ile Thr Gln Gly Glu Asn Cys 
705                 710                 715                 720 


Ile Lys Ala Phe Ile Asp Cys Cys Asn His Ile Thr Lys Leu Arg Glu 
                725                 730                 735     


Gln His Arg Arg Asp His Val Leu Gly Leu Ala Arg Ser Glu Leu Glu 
            740                 745                 750         


Glu Asp Ile Ile Pro Glu Glu Asp Ile Ile Ser Arg Ser His Phe Pro 
        755                 760                 765             


Gln Ser Trp Leu Trp Thr Ile Glu Glu Leu Lys Glu Pro Glu Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Val Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Leu Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Tyr Glu Ile Arg Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Phe Asn Tyr Arg Glu Gln Glu Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Met Ala Thr Ala Lys Asn 
865                 870                 875                 880 


Arg Tyr Phe Gln Thr Ile Lys Ile Pro Pro Lys Ser Ser Val Ala Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Ile Gly Gln Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Phe Asn His Phe Ile Ser Asp Gly Val Lys Lys Thr 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Met Arg Ile Asn Lys Thr Val Ala Ile 
    930                 935                 940                 


His Thr Leu Asp Pro Glu Lys Leu Gly Gln Gly Gly Val Gln Lys Val 
945                 950                 955                 960 


Asp Val Pro Ala Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Asp Ser 
                965                 970                 975     


Glu Thr Arg Ile Ile Leu Gln Gly Ser Pro Val Val Gln Met Ala Glu 
            980                 985                 990         


Asp Ala Val Asp Gly Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ala 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Gln  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Ile Glu  Lys Arg Gln Glu Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Lys  Gln Pro Ser Ser Ala  Tyr Ala Ala 
    1055                 1060                 1065             


Phe Asn  Asn Arg Pro Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Ala  Asn Leu Ile Ala Ile  Asp Ser His 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Gly Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Phe Arg Asn  Ala Lys Glu Ala Asp  Val Ser Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ala  Leu Gln Glu Ala Arg  Asp Ile Cys 
    1145                 1150                 1155             


Glu Gly  Gln Val Asn Ser Leu  Pro Gly Ser Ile Asn  Lys Ala Gly 
    1160                 1165                 1170             


Glu Tyr  Ile Glu Ala Ser Tyr  Met Asn Leu Gln Arg  Pro Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Leu Met Asn  Lys Leu Glu 
    1190                 1195                 1200             


Glu Pro  Tyr Leu Gly Lys Phe  Leu Asn Thr Ala Lys  Asp Arg Asn 
    1205                 1210                 1215             


Arg Trp  Glu Glu Pro Asp Gln  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Leu Leu Lys Asp  Phe Asp Ser 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Thr Asp  Val Pro Asp His Lys  Asp Leu Asn 
    1280                 1285                 1290             


Met Asp  Val Ser Phe His Leu  Pro Ser Arg Ser Ser  Ala Thr Thr 
    1295                 1300                 1305             


Phe Arg  Leu Leu Trp Glu Asn  Gly Asn Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Gln Asn Glu Ala Phe  Ser Leu Thr Ala Lys  Gly Lys Gly 
    1325                 1330                 1335             


Arg Gly  Thr Leu Ser Val Val  Ala Val Tyr His Ala  Lys Leu Lys 
    1340                 1345                 1350             


Ser Lys  Val Thr Cys Lys Lys  Phe Asp Leu Arg Val  Ser Ile Arg 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Ala Lys  Lys Pro Glu Glu Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Phe  Leu Glu Ile Cys Thr  Lys Tyr Leu Gly Asp  Val Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Lys Asp Leu Glu Leu  Leu Ala Ser Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Met Asn  Lys Ala Phe Ser Asn  Lys Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Glu Lys  Ile Ser His Thr Glu  Glu Asp Cys 
    1445                 1450                 1455             


Leu Thr  Phe Lys Val His Gln  Tyr Phe Asn Val Gly  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ser Val Lys Val Tyr  Ser Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Asp Asp Gly  Met Leu Ser 
    1490                 1495                 1500             


Lys Leu  Cys His Ser Glu Met  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Met  Gln Gln Ser Gln Glu  Lys Ile Asn Leu Asn  Val Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Glu 
    1535                 1540                 1545             


Leu Thr  Asn Ile Glu Leu Leu  Asp Asp Phe Asp Glu  Tyr Thr Met 
    1550                 1555                 1560             


Thr Ile  Gln Gln Val Ile Lys  Ser Gly Ser Asp Glu  Val Gln Ala 
    1565                 1570                 1575             


Gly Gln  Gln Arg Lys Phe Ile  Ser His Ile Lys Cys  Arg Asn Ala 
    1580                 1585                 1590             


Leu Lys  Leu Gln Lys Gly Lys  Lys Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Leu Trp Gly Glu Lys  Pro Asn Thr Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Ala Glu  Glu Cys Gln 
    1625                 1630                 1635             


Asp Gln  Lys Tyr Gln Lys Gln  Cys Glu Glu Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Tyr Gly  Cys Pro Asn 
    1655                 1660             


