
                                SEQUENCE LISTING

<110> Merck Sharp & Dohme Corp.
      Lancaster, Thomas M.
      Butters, Robert
      Choodnovskiy, Naomi
      Zion, Todd C.

<120> RECOMBINANT LECTINS, BINDING-SITE
  MODIFIED LECTINS AND USES THEREOF
  

<130> 23015

<150> 61/368,602          
<151> 2010-07-28  

<160> 29

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 237
<212> PRT
<213> Canavalin ensiformis

<400> 1
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 2
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one X is cysteine

<221> VARIANT        
<222> (7)...(19)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (94)...(105)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (203)...(213)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (223)...(233)
<223> Xaa= any codable amino acid

<400> 2
Ala Asp Thr Ile Val Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Xaa Xaa Xaa Xaa Xaa Xaa
        195                 200                 205             
Xaa Xaa Xaa Xaa Xaa Ile Ser Asn Ile Asp Ser Ser Ile Pro Xaa Xaa
    210                 215                 220                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Asp Ala Asn
225                 230                 235         


<210> 3
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (7)...(19)
<223> Xaa= any codable amino acid

<400> 3
Ala Asp Thr Ile Val Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 4
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (94)...(105)
<223> Xaa= any codable amino acid

<400> 4
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Xaa Xaa Xaa
                85                  90                  95      
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 5
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (203)...(213)
<223> Xaa= any codable amino acid

<400> 5
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Xaa Xaa Xaa Xaa Xaa Xaa
        195                 200                 205             
Xaa Xaa Xaa Xaa Xaa Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 6
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (223)...(233)
<223> Xaa= any codable amino acid

<400> 6
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Xaa Xaa
    210                 215                 220                 
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Pro Asp Ala Asn
225                 230                 235         


<210> 7
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (12)...(14)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (98)...(100)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (207)...(208)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (227)...(228)
<223> Xaa= any codable amino acid

<400> 7
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Xaa Xaa Xaa Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Xaa Xaa Xaa Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Xaa Xaa
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Xaa Xaa Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 8
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (12)...(14)
<223> Xaa= any codable amino acid

<400> 8
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Xaa Xaa Xaa Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 9
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (98)...(100)
<223> Xaa= any codable amino acid

<400> 9
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Xaa Xaa Xaa Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 10
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (207)...(208)
<223> Xaa= any codable amino acid

<400> 10
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Xaa Xaa
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 11
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (227)...(228)
<223> Xaa= any codable amino acid

<400> 11
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Xaa Xaa Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 12
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (12)...(0)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (14)...(0)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (99)...(100)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (208)...(0)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (227)...(0)
<223> Xaa= any codable amino acid

<400> 12
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Xaa Pro Xaa Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Xaa Xaa Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Xaa
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Xaa Leu Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 13
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (12)...(0)
<223> Xaa= any codable amino acid

<221> VARIANT        
<222> (14)...(0)
<223> Xaa= any codable amino acid

<400> 13
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Xaa Pro Xaa Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 14
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (99)...(100)
<223> Xaa= any codable amino acid

<400> 14
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Xaa Xaa Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 15
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (208)...(0)
<223> Xaa= any codable amino acid

<400> 15
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Xaa
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 16
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (227)...(0)
<223> Xaa= any codable amino acid

<400> 16
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Xaa Leu Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 17
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (100)...(101)
<223> Xaa= any codable amino acid

<400> 17
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Xaa Xaa Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 18
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A wherein at least one Xaa is
      cysteine

<221> VARIANT        
<222> (117)...(0)
<223> Xaa= any codable amino acid

<400> 18
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Asn Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr Ser
            100                 105                 110         
Lys Leu Lys Ser Xaa Ser Thr Xaa Glu Thr Asn Ala Leu His Phe Met
        115                 120                 125             
Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly Asp
    130                 135                 140                 
Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser Ser
145                 150                 155                 160 
Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr Ala
                165                 170                 175     
Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Gln Ala
            180                 185                 190         
Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp Gly
        195                 200                 205             
Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly Ser
    210                 215                 220                 
Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235     


<210> 19
<211> 236
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A SCI-2

<400> 19
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Asn Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Gly Leu Tyr Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr Ser
            100                 105                 110         
Lys Leu Lys Ser Cys Ser Thr Cys Glu Thr Asn Ala Leu His Phe Met
        115                 120                 125             
Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly Asp
    130                 135                 140                 
Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser Ser
145                 150                 155                 160 
Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr Ala
                165                 170                 175     
Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Gln Ala
            180                 185                 190         
Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp Gly
        195                 200                 205             
Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly Ser
    210                 215                 220                 
Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235     


<210> 20
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A SCI-3

<400> 20
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Cys Lys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 21
<211> 237
<212> PRT
<213> Artificial Sequence

<220> 
<223> Modified Con A SCI-4

<400> 21
Ala Asp Thr Ile Val Ala Val Glu Leu Asp Thr Tyr Pro Asn Thr Asp
 1               5                  10                  15      
Ile Gly Asp Pro Ser Tyr Pro His Ile Gly Ile Asp Ile Lys Ser Val
            20                  25                  30          
Arg Ser Lys Lys Thr Ala Lys Trp Asn Met Gln Asn Gly Lys Val Gly
        35                  40                  45              
Thr Ala His Ile Ile Tyr Asn Ser Val Gly Lys Arg Leu Ser Ala Val
    50                  55                  60                  
Val Ser Tyr Pro Asn Ala Asp Ser Ala Thr Val Ser Tyr Asp Val Asp
65                  70                  75                  80  
Leu Asp Asn Val Leu Pro Glu Trp Val Arg Val Gly Leu Ser Ala Ser
                85                  90                  95      
Thr Gly Leu Tyr Cys Glu Thr Asn Thr Ile Leu Ser Trp Ser Phe Thr
            100                 105                 110         
Ser Lys Leu Lys Ser Asn Ser Thr His Glu Thr Asn Ala Leu His Phe
        115                 120                 125             
Met Phe Asn Gln Phe Ser Lys Asp Gln Lys Asp Leu Ile Leu Gln Gly
    130                 135                 140                 
Asp Ala Thr Thr Gly Thr Asp Gly Asn Leu Glu Leu Thr Arg Val Ser
145                 150                 155                 160 
Ser Asn Gly Ser Pro Gln Gly Ser Ser Val Gly Arg Ala Leu Phe Tyr
                165                 170                 175     
Ala Pro Val His Ile Trp Glu Ser Ser Ala Val Val Ala Ser Phe Glu
            180                 185                 190         
Ala Thr Phe Thr Phe Leu Ile Lys Ser Pro Asp Ser His Pro Ala Asp
        195                 200                 205             
Gly Ile Ala Phe Phe Ile Ser Asn Ile Asp Ser Ser Ile Pro Ser Gly
    210                 215                 220                 
Ser Thr Gly Arg Leu Leu Gly Leu Phe Pro Asp Ala Asn
225                 230                 235         


<210> 22
<211> 21
<212> PRT
<213> Homo sapiens

<400> 22
Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu
 1               5                  10                  15      
Glu Asn Tyr Cys Asn
            20      


<210> 23
<211> 30
<212> PRT
<213> Homo sapiens

<400> 23
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr
 1               5                  10                  15      
Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr
            20                  25                  30  


<210> 24
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Insulin analog A-chain

<221> VARIANT        
<222> 1
<223> Xaa= any codable amino acid, a sequence of 1-2,
      1-3, 1-4, etc. codable amino acids, or missing

<221> VARIANT        
<222> 23
<223> Xaa= any codable amino acid, a sequence of 1-2,
      1-3, 1-4, etc. codable amino acids, or missing

<221> VARIANT        
<222> 9
<223> Xaa= any codable amino acid; or T or A

<221> VARIANT        
<222> 10
<223> Xaa= any codable amino acid; or S or G

<221> VARIANT        
<222> 11
<223> Xaa= any codable amino acid; or I or V

<221> VARIANT        
<222> (18)...(18)
<223> Xaa= any codable amino acid; or N, D, or E

<221> VARIANT        
<222> (22)...(22)
<223> Xaa= any codable amino acid; or N, D, E, G, or A

<400> 24
Xaa Gly Ile Val Glu Gln Cys Cys Xaa Xaa Xaa Cys Ser Leu Tyr Gln
 1               5                  10                  15      
Leu Glu Xaa Tyr Cys Xaa Xaa
            20              


<210> 25
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Insulin analog B-chain

<221> VARIANT        
<222> 1
<223> Xaa= any codable amino acid, a sequence of 1-2,
      1-3, 1-4, etc. codable amino acids, or missing

<221> VARIANT        
<222> 32
<223> Xaa= any codable amino acid, a sequence of 1-2,
      1-3, 1-4, etc. codable amino acids, or missing

<221> VARIANT        
<222> 4
<223> Xaa= any codable amino acid; or N, K, D, or E, or
      missing

<221> VARIANT        
<222> 29
<223> Xaa= any codable amino acid; or P, A, K, L, V, or
      D, or missing

<221> VARIANT        
<222> 30
<223> Xaa= any codable amino acid; or K, P, or E, or
      missing

<221> VARIANT        
<222> (31)...(31)
<223> Xaa= any codable amino acid or T, A, K, E, S, or
      R, or missing

<221> VARIANT        
<222> (32)...(32)
<223> Xaa= any codable amino acid, a sequence of codable
      amino acids (e.g., 1-2, 1-3, 1-4, etc. codable
      amino acids), Arg-Arg, or missing

<400> 25
Xaa Phe Val Xaa Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu
 1               5                  10                  15      
Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Xaa Xaa Xaa Xaa
            20                  25                  30          
Xaa
    


<210> 26
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> Encodes SCI-1

<400> 26
atggctaccg tagcgcaagc tgctgatacc attgtggcgg tggaactgga tacctatccg 60
aacaccgata ttggcgatcc gagctatccg catattggca tcgatatcaa aagcgtgcgc 120
agcaaaaaaa ccgcgaaatg gaacatgcag aacggtaaag ttggcaccgc gcacatcatc 180
tataactctg ttggtaagag actaagtgct gttgtttctt atcctaacgc tgactctgcc 240
actgtctctt acgacgttga cctcgacaat gtccttcctg aatgggttag agttggcctt 300
tctgcttcaa ccggacttta caaagaaacc aataccattc tctcatggtc ttttacttct 360
aagttgaaga gcaattcaac acatgagaca aatgcactcc atttcatgtt caaccaattt 420
agcaaagatc agaaggattt gatccttcaa ggtgacgcca caacaggaac agatggtaac 480
ttggaactca caagggtgtc aagtaatggg agtccacagg gaagcagtgt gggccgggct 540
ttgttctatg ccccagtcca catttgggaa agttctgctg tggtggcaag ctttgaagct 600
acctttacat ttctcataaa atcacccgac tctcacccag ctgatggaat tgccttcttc 660
atttcaaata ttgacagttc catccctagt ggttccactg gaaggctcct tggactcttc 720
cctgatgcaa attga                                                  735

<210> 27
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> Encodes SCI-2

<400> 27
atggctaccg tagcgcaagc tgctgatacc attgtggcgg tggaactgga tacctatccg 60
aacaccgata ttggcgatcc gagctatccg catattggca tcgatatcaa aagcgtgcgc 120
agcaaaaaaa ccgcgaaatg gaacatgcag aacggtaaag ttggcaccgc gcacatcatc 180
tataactctg ttaataagag actaagtgct gttgtttctt atcctaacgc tgactctgcc 240
actgtctctt acgacgttga cctcgacaat gtccttcctg aatgggttag agttggcctt 300
tctgcttcaa ccggacttta caaagaaacc aataccattc tctcatggtc ttttacttct 360
aagttgaaga gctgttcaac atgtgagaca aatgcactcc atttcatgtt caaccaattt 420
agcaaagatc agaaggattt gatccttcaa ggtgacgcca caacaggaac agatggtaac 480
ttggaactca caagggtgtc aagtaatggg agtccacagg gaagcagtgt gggccgggct 540
ttgttctatg ccccagtcca catttgggaa agttctgctg tggtggcaag ctttcaagct 600
acctttacat ttctcataaa atcacccgac tctcacccag ctgatggaat tgccttcttc 660
atttcaaata ttgacagttc catccctagt ggttccactg gaaggctcct tggactcttc 720
cctgatgcaa attga                                                  735

<210> 28
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> Encodes SCI-3

<400> 28
atggctaccg tagcgcaagc tgctgatacc attgtggcgg tggaactgga tacctatccg 60
aacaccgata ttggcgatcc gagctatccg catattggca tcgatatcaa aagcgtgcgc 120
agcaaaaaaa ccgcgaaatg gaacatgcag aacggtaaag ttggcaccgc gcacatcatc 180
tataactctg ttggtaagag actaagtgct gttgtttctt atcctaacgc tgactctgcc 240
actgtctctt acgacgttga cctcgacaat gtccttcctg aatgggttag agttggcctt 300
tctgcttcaa ccggactttg taaagaaacc aataccattc tctcatggtc ttttacttct 360
aagttgaaga gcaattcaac acatgagaca aatgcactcc atttcatgtt caaccaattt 420
agcaaagatc agaaggattt gatccttcaa ggtgacgcca caacaggaac agatggtaac 480
ttggaactca caagggtgtc aagtaatggg agtccacagg gaagcagtgt gggccgggct 540
ttgttctatg ccccagtcca catttgggaa agttctgctg tggtggcaag ctttgaagct 600
acctttacat ttctcataaa atcacccgac tctcacccag ctgatggaat tgccttcttc 660
atttcaaata ttgacagttc catccctagt ggttccactg gaaggctcct tggactcttc 720
cctgatgcaa attga                                                  735

<210> 29
<211> 735
<212> DNA
<213> Artificial Sequence

<220> 
<223> Encodes SCI-4

<400> 29
atggctaccg tagcgcaagc tgctgatacc attgtggcgg tggaactgga tacctatccg 60
aacaccgata ttggcgatcc gagctatccg catattggca tcgatatcaa aagcgtgcgc 120
agcaaaaaaa ccgcgaaatg gaacatgcag aacggtaaag ttggcaccgc gcacatcatc 180
tataactctg ttggtaagag actaagtgct gttgtttctt atcctaacgc tgactctgcc 240
actgtctctt acgacgttga cctcgacaat gtccttcctg aatgggttag agttggcctt 300
tctgcttcaa ccggacttta ctgtgaaacc aataccattc tctcatggtc ttttacttct 360
aagttgaaga gcaattcaac acatgagaca aatgcactcc atttcatgtt caaccaattt 420
agcaaagatc agaaggattt gatccttcaa ggtgacgcca caacaggaac agatggtaac 480
ttggaactca caagggtgtc aagtaatggg agtccacagg gaagcagtgt gggccgggct 540
ttgttctatg ccccagtcca catttgggaa agttctgctg tggtggcaag ctttgaagct 600
acctttacat ttctcataaa atcacccgac tctcacccag ctgatggaat tgccttcttc 660
atttcaaata ttgacagttc catccctagt ggttccactg gaaggctcct tggactcttc 720
cctgatgcaa attga                                                  735
