                         SEQUENCE LISTING

<110>  Universitt Leipzig
 
<120>  Method and compositions for the identification of agents that have a potential effect against chronic inflammatory diseases

<130>  00401P0049EPWO

<150>  EP 10 171 469.9

<151>  30.07.2010


<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  1
tgctgttgac agtgagcgcg catattcaat cattctcaaa tagtgaagcc acagatgtat     60

ttgagaatga ttgaatatgc atgcctactg cctcgga                              97


<210>  2
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  2
tgctgttgac agtgagcgac cagtgacttc catcaaatta tagtgaagcc acagatgtat     60

aatttgatgg aagtcactgg gtgcctactg cctcgga                              97


<210>  3
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  3
tgctgttgac agtgagcgac cttcagcttt gatcccaaat tagtgaagcc acagatgtaa     60

tttgggatca aagctgaagg ctgcctactg cctcgga                              97


<210>  4
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  4
ccggcgatcc ttattatctt cacttctcga gaagtgaaga taataaggat cgttttt        57


<210>  5
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  5
ccggccagga ctcattcata gtattctcga gaatactatg aatgagtcct ggttttt        57


<210>  6
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  6
ccgggctgtg gagattattg tcatactcga gtatgacaat aatctccaca gcttttt        57


<210>  7
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  7
ccggccacaa atccaggagt gtgttctcga gaacacactc ctggatttgt ggttttt        57


<210>  8
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA

<400>  8
ccgggaagca aataacgtgt gcatactcga gtatgcacac gttatttgct tcttttt        57


<210>  9
<211>  2860
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (23)..(2803)

<400>  9
actgagcaaa tgagatagaa ac atg gca ttc tta att ata cta att acc tgc      52
                         Met Ala Phe Leu Ile Ile Leu Ile Thr Cys        
                         1               5                   10         

ttt gtg att att ctt gct act tca cag cct tgc cag acc cct gat gac      100
Phe Val Ile Ile Leu Ala Thr Ser Gln Pro Cys Gln Thr Pro Asp Asp         
                15                  20                  25              

ttt gtg gct gcc act tct ccg gga cat atc ata att gga ggt ttg ttt      148
Phe Val Ala Ala Thr Ser Pro Gly His Ile Ile Ile Gly Gly Leu Phe         
            30                  35                  40                  

gct att cat gaa aaa atg ttg tcc tca gaa gac tct ccc aga cga cca      196
Ala Ile His Glu Lys Met Leu Ser Ser Glu Asp Ser Pro Arg Arg Pro         
        45                  50                  55                      

caa atc cag gag tgt gtt ggc ttt gaa ata tca gtt ttt ctt caa act      244
Gln Ile Gln Glu Cys Val Gly Phe Glu Ile Ser Val Phe Leu Gln Thr         
    60                  65                  70                          

ctt gcc atg ata cac agc att gag atg atc aac aat tca aca ctc tta      292
Leu Ala Met Ile His Ser Ile Glu Met Ile Asn Asn Ser Thr Leu Leu         
75                  80                  85                  90          

cct gga gtc aaa ctg ggg tat gaa atc tat gac act tgt aca gaa gtc      340
Pro Gly Val Lys Leu Gly Tyr Glu Ile Tyr Asp Thr Cys Thr Glu Val         
                95                  100                 105             

aca gtg gca atg gca gcc act ctg agg ttt ctt tct aaa ttc aac tgc      388
Thr Val Ala Met Ala Ala Thr Leu Arg Phe Leu Ser Lys Phe Asn Cys         
            110                 115                 120                 

tcc aga gaa act gtg gag ttt aag tgt gac tat tcc agc tac atg cca      436
Ser Arg Glu Thr Val Glu Phe Lys Cys Asp Tyr Ser Ser Tyr Met Pro         
        125                 130                 135                     

aga gtt aag gct gtc ata ggt tct ggg tac tca gaa ata act atg gct      484
Arg Val Lys Ala Val Ile Gly Ser Gly Tyr Ser Glu Ile Thr Met Ala         
    140                 145                 150                         

gtc tcc agg atg ttg aat tta cag ctc atg cca cag gtg ggt tat gaa      532
Val Ser Arg Met Leu Asn Leu Gln Leu Met Pro Gln Val Gly Tyr Glu         
155                 160                 165                 170         

tca act gca gaa atc ctg agt gac aaa att cgc ttt cct tca ttt tta      580
Ser Thr Ala Glu Ile Leu Ser Asp Lys Ile Arg Phe Pro Ser Phe Leu         
                175                 180                 185             

cgg act gtg ccc agt gac ttc cat caa att aaa gca atg gct cac ctg      628
Arg Thr Val Pro Ser Asp Phe His Gln Ile Lys Ala Met Ala His Leu         
            190                 195                 200                 

att cag aaa tct ggt tgg aac tgg att ggc atc ata acc aca gat gat      676
Ile Gln Lys Ser Gly Trp Asn Trp Ile Gly Ile Ile Thr Thr Asp Asp         
        205                 210                 215                     

gac tat gga cga ttg gct ctt aac act ttt ata att cag gct gaa gca      724
Asp Tyr Gly Arg Leu Ala Leu Asn Thr Phe Ile Ile Gln Ala Glu Ala         
    220                 225                 230                         

aat aac gtg tgc ata gcc ttc aaa gag gtt ctt cca gcc ttt ctt tca      772
Asn Asn Val Cys Ile Ala Phe Lys Glu Val Leu Pro Ala Phe Leu Ser         
235                 240                 245                 250         

gat aat acc att gaa gtc aga atc aat cgg aca ctg aag aaa atc att      820
Asp Asn Thr Ile Glu Val Arg Ile Asn Arg Thr Leu Lys Lys Ile Ile         
                255                 260                 265             

tta gaa gcc cag gtt aat gtc att gtg gta ttt ctg agg caa ttc cat      868
Leu Glu Ala Gln Val Asn Val Ile Val Val Phe Leu Arg Gln Phe His         
            270                 275                 280                 

gtt ttt gat ctc ttc aat aaa gcc att gaa atg aat ata aat aag atg      916
Val Phe Asp Leu Phe Asn Lys Ala Ile Glu Met Asn Ile Asn Lys Met         
        285                 290                 295                     

tgg att gct agt gat aat tgg tca act gcc acc aag att acc acc att      964
Trp Ile Ala Ser Asp Asn Trp Ser Thr Ala Thr Lys Ile Thr Thr Ile         
    300                 305                 310                         

cct aat gtt aaa aag att ggc aaa gtt gta ggg ttt gcc ttt aga aga     1012
Pro Asn Val Lys Lys Ile Gly Lys Val Val Gly Phe Ala Phe Arg Arg         
315                 320                 325                 330         

ggg aat ata tcc tct ttc cat tcc ttt ctt caa aat ctg cac ttg ctt     1060
Gly Asn Ile Ser Ser Phe His Ser Phe Leu Gln Asn Leu His Leu Leu         
                335                 340                 345             

ccc agt gac agt cac aaa ctc tta cat gaa tat gcc atg cat tta tct     1108
Pro Ser Asp Ser His Lys Leu Leu His Glu Tyr Ala Met His Leu Ser         
            350                 355                 360                 

gcc tgc gca tat gtc aag gac act gat ttg agt caa tgc ata ttc aat     1156
Ala Cys Ala Tyr Val Lys Asp Thr Asp Leu Ser Gln Cys Ile Phe Asn         
        365                 370                 375                     

cat tct caa agg act ttg gcc tac aag gct aac aag gct ata gaa agg     1204
His Ser Gln Arg Thr Leu Ala Tyr Lys Ala Asn Lys Ala Ile Glu Arg         
    380                 385                 390                         

aac ttc gtc atg aga aat gac ttc ctc tgg gac tat gct gag cca gga     1252
Asn Phe Val Met Arg Asn Asp Phe Leu Trp Asp Tyr Ala Glu Pro Gly         
395                 400                 405                 410         

ctc att cat agt att cag ctt gca gtg ttt gcc ctt ggt tat gcc att     1300
Leu Ile His Ser Ile Gln Leu Ala Val Phe Ala Leu Gly Tyr Ala Ile         
                415                 420                 425             

cgg gat ctg tgt caa gct cgt gac tgt cag aac ccc aac gcc ttt caa     1348
Arg Asp Leu Cys Gln Ala Arg Asp Cys Gln Asn Pro Asn Ala Phe Gln         
            430                 435                 440                 

cca tgg gag tta ctt ggt gtg cta aaa aat gtg aca ttc act gat gga     1396
Pro Trp Glu Leu Leu Gly Val Leu Lys Asn Val Thr Phe Thr Asp Gly         
        445                 450                 455                     

tgg aat tca ttt cat ttt gat gct cac ggg gat tta aat act gga tat     1444
Trp Asn Ser Phe His Phe Asp Ala His Gly Asp Leu Asn Thr Gly Tyr         
    460                 465                 470                         

gat gtt gtg ctc tgg aag gag atc aat gga cac atg act gtc act aag     1492
Asp Val Val Leu Trp Lys Glu Ile Asn Gly His Met Thr Val Thr Lys         
475                 480                 485                 490         

atg gca gaa tat gac cta cag aat gat gtc ttc atc atc cca gat cag     1540
Met Ala Glu Tyr Asp Leu Gln Asn Asp Val Phe Ile Ile Pro Asp Gln         
                495                 500                 505             

gaa aca aaa aat gag ttc agg aat ctt aag caa att caa tct aaa tgc     1588
Glu Thr Lys Asn Glu Phe Arg Asn Leu Lys Gln Ile Gln Ser Lys Cys         
            510                 515                 520                 

tcc aag gaa tgc agt cct ggg caa atg aag aaa act aca aga agt caa     1636
Ser Lys Glu Cys Ser Pro Gly Gln Met Lys Lys Thr Thr Arg Ser Gln         
        525                 530                 535                     

cac atc tgt tgc tat gaa tgt cag aac tgt cct gaa aat cat tac act     1684
His Ile Cys Cys Tyr Glu Cys Gln Asn Cys Pro Glu Asn His Tyr Thr         
    540                 545                 550                         

aat cag aca gat atg cct cac tgc ctt tta tgc aac aac aaa act cac     1732
Asn Gln Thr Asp Met Pro His Cys Leu Leu Cys Asn Asn Lys Thr His         
555                 560                 565                 570         

tgg gcc cct gtt agg agc act atg tgc ttt gaa aag gaa gtg gaa tat     1780
Trp Ala Pro Val Arg Ser Thr Met Cys Phe Glu Lys Glu Val Glu Tyr         
                575                 580                 585             

ctc aac tgg aat gac tcc ttg gcc atc cta ctc ctg att ctc tcc cta     1828
Leu Asn Trp Asn Asp Ser Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu         
            590                 595                 600                 

ctg gga atc ata ttt gtt ctg gtt gtt ggc ata ata ttt aca aga aac     1876
Leu Gly Ile Ile Phe Val Leu Val Val Gly Ile Ile Phe Thr Arg Asn         
        605                 610                 615                     

ctg aac aca cct gtt gtg aaa tca tcc ggg gga tta aga gtc tgc tat     1924
Leu Asn Thr Pro Val Val Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr         
    620                 625                 630                         

gtg atc ctt ctc tgt cat ttc ctc aat ttt gcc agc acg agc ttt ttc     1972
Val Ile Leu Leu Cys His Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe         
635                 640                 645                 650         

att gga gaa cca caa gac ttc aca tgt aaa acc agg cag aca atg ttt     2020
Ile Gly Glu Pro Gln Asp Phe Thr Cys Lys Thr Arg Gln Thr Met Phe         
                655                 660                 665             

gga gtg agc ttt act ctt tgc atc tcc tgc att ttg acg aag tct ctg     2068
Gly Val Ser Phe Thr Leu Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu         
            670                 675                 680                 

aaa att ttg cta gcc ttc agc ttt gat ccc aaa tta cag aaa ttt ctg     2116
Lys Ile Leu Leu Ala Phe Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu         
        685                 690                 695                     

aag tgc ctc tat aga ccg atc ctt att atc ttc act tgc acg ggc atc     2164
Lys Cys Leu Tyr Arg Pro Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile         
    700                 705                 710                         

cag gtt gtc att tgc aca ctc tgg cta atc ttt gca gca cct act gta     2212
Gln Val Val Ile Cys Thr Leu Trp Leu Ile Phe Ala Ala Pro Thr Val         
715                 720                 725                 730         

gag gtg aat gtc tcc ttg ccc aga gtc atc atc ctg gag tgt gag gag     2260
Glu Val Asn Val Ser Leu Pro Arg Val Ile Ile Leu Glu Cys Glu Glu         
                735                 740                 745             

gga tcc ata ctt gca ttt ggc acc atg ctg ggc tac att gcc atc ctg     2308
Gly Ser Ile Leu Ala Phe Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu         
            750                 755                 760                 

gcc ttc att tgc ttc ata ttt gct ttc aaa ggc aaa tat gag aat tac     2356
Ala Phe Ile Cys Phe Ile Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr         
        765                 770                 775                     

aat gaa gcc aaa ttc att aca ttt ggc atg ctc att tac ttc ata gct     2404
Asn Glu Ala Lys Phe Ile Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala         
    780                 785                 790                         

tgg atc aca ttc atc cct atc tat gct acc aca ttt ggc aaa tat gta     2452
Trp Ile Thr Phe Ile Pro Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val         
795                 800                 805                 810         

cca gct gtg gag att att gtc ata tta ata tct aac tat gga atc ctg     2500
Pro Ala Val Glu Ile Ile Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu         
                815                 820                 825             

tat tgc aca ttc atc ccc aaa tgc tat gtt att att tgt aag caa gag     2548
Tyr Cys Thr Phe Ile Pro Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu         
            830                 835                 840                 

att aac aca aag tct gcc ttt ctc aag atg atc tac agt tat tct tcc     2596
Ile Asn Thr Lys Ser Ala Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser         
        845                 850                 855                     

cat agt gtg agc agc att gcc ctg agt cct gct tca ctg gac tcc atg     2644
His Ser Val Ser Ser Ile Ala Leu Ser Pro Ala Ser Leu Asp Ser Met         
    860                 865                 870                         

agc ggc aat gtc aca atg acc aat ccc agc tct agt ggc aag tct gca     2692
Ser Gly Asn Val Thr Met Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala         
875                 880                 885                 890         

acc tgg cag aaa agc aaa gat ctt cag gca caa gca ttt gca cac ata     2740
Thr Trp Gln Lys Ser Lys Asp Leu Gln Ala Gln Ala Phe Ala His Ile         
                895                 900                 905             

tgc agg gaa aat gcc aca agt gta tct aaa act ttg cct cga aaa aga     2788
Cys Arg Glu Asn Ala Thr Ser Val Ser Lys Thr Leu Pro Arg Lys Arg         
            910                 915                 920                 

atg tca agt ata tga ataagcctta ggagatgcca cattccagaa taaaatgttt     2843
Met Ser Ser Ile                                                         
        925                                                             

ccagggtctt tgcatct                                                  2860


<210>  10
<211>  926
<212>  PRT
<213>  homo sapiens

<400>  10

Met Ala Phe Leu Ile Ile Leu Ile Thr Cys Phe Val Ile Ile Leu Ala 
1               5                   10                  15      


Thr Ser Gln Pro Cys Gln Thr Pro Asp Asp Phe Val Ala Ala Thr Ser 
            20                  25                  30          


Pro Gly His Ile Ile Ile Gly Gly Leu Phe Ala Ile His Glu Lys Met 
        35                  40                  45              


Leu Ser Ser Glu Asp Ser Pro Arg Arg Pro Gln Ile Gln Glu Cys Val 
    50                  55                  60                  


Gly Phe Glu Ile Ser Val Phe Leu Gln Thr Leu Ala Met Ile His Ser 
65                  70                  75                  80  


Ile Glu Met Ile Asn Asn Ser Thr Leu Leu Pro Gly Val Lys Leu Gly 
                85                  90                  95      


Tyr Glu Ile Tyr Asp Thr Cys Thr Glu Val Thr Val Ala Met Ala Ala 
            100                 105                 110         


Thr Leu Arg Phe Leu Ser Lys Phe Asn Cys Ser Arg Glu Thr Val Glu 
        115                 120                 125             


Phe Lys Cys Asp Tyr Ser Ser Tyr Met Pro Arg Val Lys Ala Val Ile 
    130                 135                 140                 


Gly Ser Gly Tyr Ser Glu Ile Thr Met Ala Val Ser Arg Met Leu Asn 
145                 150                 155                 160 


Leu Gln Leu Met Pro Gln Val Gly Tyr Glu Ser Thr Ala Glu Ile Leu 
                165                 170                 175     


Ser Asp Lys Ile Arg Phe Pro Ser Phe Leu Arg Thr Val Pro Ser Asp 
            180                 185                 190         


Phe His Gln Ile Lys Ala Met Ala His Leu Ile Gln Lys Ser Gly Trp 
        195                 200                 205             


Asn Trp Ile Gly Ile Ile Thr Thr Asp Asp Asp Tyr Gly Arg Leu Ala 
    210                 215                 220                 


Leu Asn Thr Phe Ile Ile Gln Ala Glu Ala Asn Asn Val Cys Ile Ala 
225                 230                 235                 240 


Phe Lys Glu Val Leu Pro Ala Phe Leu Ser Asp Asn Thr Ile Glu Val 
                245                 250                 255     


Arg Ile Asn Arg Thr Leu Lys Lys Ile Ile Leu Glu Ala Gln Val Asn 
            260                 265                 270         


Val Ile Val Val Phe Leu Arg Gln Phe His Val Phe Asp Leu Phe Asn 
        275                 280                 285             


Lys Ala Ile Glu Met Asn Ile Asn Lys Met Trp Ile Ala Ser Asp Asn 
    290                 295                 300                 


Trp Ser Thr Ala Thr Lys Ile Thr Thr Ile Pro Asn Val Lys Lys Ile 
305                 310                 315                 320 


Gly Lys Val Val Gly Phe Ala Phe Arg Arg Gly Asn Ile Ser Ser Phe 
                325                 330                 335     


His Ser Phe Leu Gln Asn Leu His Leu Leu Pro Ser Asp Ser His Lys 
            340                 345                 350         


Leu Leu His Glu Tyr Ala Met His Leu Ser Ala Cys Ala Tyr Val Lys 
        355                 360                 365             


Asp Thr Asp Leu Ser Gln Cys Ile Phe Asn His Ser Gln Arg Thr Leu 
    370                 375                 380                 


Ala Tyr Lys Ala Asn Lys Ala Ile Glu Arg Asn Phe Val Met Arg Asn 
385                 390                 395                 400 


Asp Phe Leu Trp Asp Tyr Ala Glu Pro Gly Leu Ile His Ser Ile Gln 
                405                 410                 415     


Leu Ala Val Phe Ala Leu Gly Tyr Ala Ile Arg Asp Leu Cys Gln Ala 
            420                 425                 430         


Arg Asp Cys Gln Asn Pro Asn Ala Phe Gln Pro Trp Glu Leu Leu Gly 
        435                 440                 445             


Val Leu Lys Asn Val Thr Phe Thr Asp Gly Trp Asn Ser Phe His Phe 
    450                 455                 460                 


Asp Ala His Gly Asp Leu Asn Thr Gly Tyr Asp Val Val Leu Trp Lys 
465                 470                 475                 480 


Glu Ile Asn Gly His Met Thr Val Thr Lys Met Ala Glu Tyr Asp Leu 
                485                 490                 495     


Gln Asn Asp Val Phe Ile Ile Pro Asp Gln Glu Thr Lys Asn Glu Phe 
            500                 505                 510         


Arg Asn Leu Lys Gln Ile Gln Ser Lys Cys Ser Lys Glu Cys Ser Pro 
        515                 520                 525             


Gly Gln Met Lys Lys Thr Thr Arg Ser Gln His Ile Cys Cys Tyr Glu 
    530                 535                 540                 


Cys Gln Asn Cys Pro Glu Asn His Tyr Thr Asn Gln Thr Asp Met Pro 
545                 550                 555                 560 


His Cys Leu Leu Cys Asn Asn Lys Thr His Trp Ala Pro Val Arg Ser 
                565                 570                 575     


Thr Met Cys Phe Glu Lys Glu Val Glu Tyr Leu Asn Trp Asn Asp Ser 
            580                 585                 590         


Leu Ala Ile Leu Leu Leu Ile Leu Ser Leu Leu Gly Ile Ile Phe Val 
        595                 600                 605             


Leu Val Val Gly Ile Ile Phe Thr Arg Asn Leu Asn Thr Pro Val Val 
    610                 615                 620                 


Lys Ser Ser Gly Gly Leu Arg Val Cys Tyr Val Ile Leu Leu Cys His 
625                 630                 635                 640 


Phe Leu Asn Phe Ala Ser Thr Ser Phe Phe Ile Gly Glu Pro Gln Asp 
                645                 650                 655     


Phe Thr Cys Lys Thr Arg Gln Thr Met Phe Gly Val Ser Phe Thr Leu 
            660                 665                 670         


Cys Ile Ser Cys Ile Leu Thr Lys Ser Leu Lys Ile Leu Leu Ala Phe 
        675                 680                 685             


Ser Phe Asp Pro Lys Leu Gln Lys Phe Leu Lys Cys Leu Tyr Arg Pro 
    690                 695                 700                 


Ile Leu Ile Ile Phe Thr Cys Thr Gly Ile Gln Val Val Ile Cys Thr 
705                 710                 715                 720 


Leu Trp Leu Ile Phe Ala Ala Pro Thr Val Glu Val Asn Val Ser Leu 
                725                 730                 735     


Pro Arg Val Ile Ile Leu Glu Cys Glu Glu Gly Ser Ile Leu Ala Phe 
            740                 745                 750         


Gly Thr Met Leu Gly Tyr Ile Ala Ile Leu Ala Phe Ile Cys Phe Ile 
        755                 760                 765             


Phe Ala Phe Lys Gly Lys Tyr Glu Asn Tyr Asn Glu Ala Lys Phe Ile 
    770                 775                 780                 


Thr Phe Gly Met Leu Ile Tyr Phe Ile Ala Trp Ile Thr Phe Ile Pro 
785                 790                 795                 800 


Ile Tyr Ala Thr Thr Phe Gly Lys Tyr Val Pro Ala Val Glu Ile Ile 
                805                 810                 815     


Val Ile Leu Ile Ser Asn Tyr Gly Ile Leu Tyr Cys Thr Phe Ile Pro 
            820                 825                 830         


Lys Cys Tyr Val Ile Ile Cys Lys Gln Glu Ile Asn Thr Lys Ser Ala 
        835                 840                 845             


Phe Leu Lys Met Ile Tyr Ser Tyr Ser Ser His Ser Val Ser Ser Ile 
    850                 855                 860                 


Ala Leu Ser Pro Ala Ser Leu Asp Ser Met Ser Gly Asn Val Thr Met 
865                 870                 875                 880 


Thr Asn Pro Ser Ser Ser Gly Lys Ser Ala Thr Trp Gln Lys Ser Lys 
                885                 890                 895     


Asp Leu Gln Ala Gln Ala Phe Ala His Ile Cys Arg Glu Asn Ala Thr 
            900                 905                 910         


Ser Val Ser Lys Thr Leu Pro Arg Lys Arg Met Ser Ser Ile 
        915                 920                 925     


<210>  11
<211>  5009
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (439)..(3705)

<400>  11
ggggctgctg tggccggacc cgaaggcggg cgccgggagc gcagcgagcc agacgcgcct     60

ctccaagacc gtgaccttgg catagggagc ggggctgcgc gcagtcctga gatcagacca    120

gagctcatcc tcgtggagac ccacggccga ggggccggag ctgcctctgt gcgagggagc    180

cctggccgcg gcgcagaagg catcacagga ggcctctgca tgatgtggct tccaaagact    240

caaggaccac ccacattaca agtctggatt gaggaaggca gaaatggaga ttcaaacacc    300

acgtcttcta ttattttatt aatcaatctg tagacatgtg tccccactgc agggagtgaa    360

ctgctccaag ggagaaactt ctgggagcct ccaaactcct agctgtctca tcccttgccc    420

tggagagacg gcagaacc atg gca ttt tat agc tgc tgc tgg gtc ctc ttg      471
                    Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu         
                    1               5                   10              

gca ctc acc tgg cac acc tct gcc tac ggg cca gac cag cga gcc caa      519
Ala Leu Thr Trp His Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln         
            15                  20                  25                  

aag aag ggg gac att atc ctt ggg ggg ctc ttt cct att cat ttt gga      567
Lys Lys Gly Asp Ile Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly         
        30                  35                  40                      

gta gca gct aaa gat caa gat ctc aaa tca agg ccg gag tct gtg gaa      615
Val Ala Ala Lys Asp Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu         
    45                  50                  55                          

tgt atc agg tat aat ttc cgt ggg ttt cgc tgg tta cag gct atg ata      663
Cys Ile Arg Tyr Asn Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile         
60                  65                  70                  75          

ttt gcc ata gag gag ata aac agc agc cca gcc ctt ctt ccc aac ttg      711
Phe Ala Ile Glu Glu Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu         
                80                  85                  90              

acg ctg gga tac agg ata ttt gac act tgc aac acc gtt tct aag gcc      759
Thr Leu Gly Tyr Arg Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala         
            95                  100                 105                 

ttg gaa gcc acc ctg agt ttt gtt gct caa aac aaa att gat tct ttg      807
Leu Glu Ala Thr Leu Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu         
        110                 115                 120                     

aac ctt gat gag ttc tgc aac tgc tca gag cac att ccc tct acg att      855
Asn Leu Asp Glu Phe Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile         
    125                 130                 135                         

gct gtg gtg gga gca act ggc tca ggc gtc tcc acg gca gtg gca aat      903
Ala Val Val Gly Ala Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn         
140                 145                 150                 155         

ctg ctg ggg ctc ttc tac att ccc cag gtc agt tat gcc tcc tcc agc      951
Leu Leu Gly Leu Phe Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser         
                160                 165                 170             

aga ctc ctc agc aac aag aat caa ttc aag tct ttc ctc cga acc atc      999
Arg Leu Leu Ser Asn Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile         
            175                 180                 185                 

ccc aat gat gag cac cag gcc act gcc atg gca gac atc atc gag tat     1047
Pro Asn Asp Glu His Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr         
        190                 195                 200                     

ttc cgc tgg aac tgg gtg ggc aca att gca gct gat gac gac tat ggg     1095
Phe Arg Trp Asn Trp Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly         
    205                 210                 215                         

cgg ccg ggg att gag aaa ttc cga gag gaa gct gag gaa agg gat atc     1143
Arg Pro Gly Ile Glu Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile         
220                 225                 230                 235         

tgc atc gac ttc agt gaa ctc atc tcc cag tac tct gat gag gaa gag     1191
Cys Ile Asp Phe Ser Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu         
                240                 245                 250             

atc cag cat gtg gta gag gtg att caa aat tcc acg gcc aaa gtc atc     1239
Ile Gln His Val Val Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile         
            255                 260                 265                 

gtg gtt ttc tcc agt ggc cca gat ctt gag ccc ctc atc aag gag att     1287
Val Val Phe Ser Ser Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile         
        270                 275                 280                     

gtc cgg cgc aat atc acg ggc aag atc tgg ctg gcc agc gag gcc tgg     1335
Val Arg Arg Asn Ile Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp         
    285                 290                 295                         

gcc agc tcc tcc ctg atc gcc atg cct cag tac ttc cac gtg gtt ggc     1383
Ala Ser Ser Ser Leu Ile Ala Met Pro Gln Tyr Phe His Val Val Gly         
300                 305                 310                 315         

ggc acc att gga ttc gct ctg aag gct ggg cag atc cca ggc ttc cgg     1431
Gly Thr Ile Gly Phe Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg         
                320                 325                 330             

gaa ttc ctg aag aag gtc cat ccc agg aag tct gtc cac aat ggt ttt     1479
Glu Phe Leu Lys Lys Val His Pro Arg Lys Ser Val His Asn Gly Phe         
            335                 340                 345                 

gcc aag gag ttt tgg gaa gaa aca ttt aac tgc cac ctc caa gaa ggt     1527
Ala Lys Glu Phe Trp Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly         
        350                 355                 360                     

gca aaa gga cct tta cct gtg gac acc ttt ctg aga ggt cac gaa gaa     1575
Ala Lys Gly Pro Leu Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu         
    365                 370                 375                         

agt ggc gac agg ttt agc aac agc tcg aca gcc ttc cga ccc ctc tgt     1623
Ser Gly Asp Arg Phe Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys         
380                 385                 390                 395         

aca ggg gat gag aac atc agc agt gtc gag acc cct tac ata gat tac     1671
Thr Gly Asp Glu Asn Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr         
                400                 405                 410             

acg cat tta cgg ata tcc tac aat gtg tac tta gca gtc tac tcc att     1719
Thr His Leu Arg Ile Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile         
            415                 420                 425                 

gcc cac gcc ttg caa gat ata tat acc tgc tta cct ggg aga ggg ctc     1767
Ala His Ala Leu Gln Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu         
        430                 435                 440                     

ttc acc aat ggc tcc tgt gca gac atc aag aaa gtt gag gcg tgg cag     1815
Phe Thr Asn Gly Ser Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln         
    445                 450                 455                         

gtc ctg aag cac cta cgg cat cta aac ttt aca aac aat atg ggg gag     1863
Val Leu Lys His Leu Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu         
460                 465                 470                 475         

cag gtg acc ttt gat gag tgt ggt gac ctg gtg ggg aac tat tcc atc     1911
Gln Val Thr Phe Asp Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile         
                480                 485                 490             

atc aac tgg cac ctc tcc cca gag gat ggc tcc atc gtg ttt aag gaa     1959
Ile Asn Trp His Leu Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu         
            495                 500                 505                 

gtc ggg tat tac aac gtc tat gcc aag aag gga gaa aga ctc ttc atc     2007
Val Gly Tyr Tyr Asn Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile         
        510                 515                 520                     

aac gag gag aaa atc ctg tgg agt ggg ttc tcc agg gag cca ctc acc     2055
Asn Glu Glu Lys Ile Leu Trp Ser Gly Phe Ser Arg Glu Pro Leu Thr         
    525                 530                 535                         

ttt gtg ctg tct gtc ctc cag gtg ccc ttc tcc aac tgc agc cga gac     2103
Phe Val Leu Ser Val Leu Gln Val Pro Phe Ser Asn Cys Ser Arg Asp         
540                 545                 550                 555         

tgc ctg gca ggg acc agg aaa ggg atc att gag ggg gag ccc acc tgc     2151
Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr Cys         
                560                 565                 570             

tgc ttt gag tgt gtg gag tgt cct gat ggg gag tat agt gat gag aca     2199
Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu Thr         
            575                 580                 585                 

gat gcc agt gcc tgt aac aag tgc cca gat gac ttc tgg tcc aat gag     2247
Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn Glu         
        590                 595                 600                     

aac cac acc tcc tgc att gcc aag gag atc gag ttt ctg tcg tgg acg     2295
Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp Thr         
    605                 610                 615                         

gag ccc ttt ggg atc gca ctc acc ctc ttt gcc gtg ctg ggc att ttc     2343
Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile Phe         
620                 625                 630                 635         

ctg aca gcc ttt gtg ctg ggt gtg ttt atc aag ttc cgc aac aca ccc     2391
Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr Pro         
                640                 645                 650             

att gtc aag gcc acc aac cga gag ctc tcc tac ctc ctc ctc ttc tcc     2439
Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe Ser         
            655                 660                 665                 

ctg ctc tgc tgc ttc tcc agc tcc ctg ttc ttc atc ggg gag ccc cag     2487
Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro Gln         
        670                 675                 680                     

gac tgg acg tgc cgc ctg cgc cag ccg gcc ttt ggc atc agc ttc gtg     2535
Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe Val         
    685                 690                 695                         

ctc tgc atc tca tgc atc ctg gtg aaa acc aac cgt gtc ctc ctg gtg     2583
Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu Val         
700                 705                 710                 715         

ttt gag gcc aag atc ccc acc agc ttc cac cgc aag tgg tgg ggg ctc     2631
Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly Leu         
                720                 725                 730             

aac ctg cag ttc ctg ctg gtt ttc ctc tgc acc ttc atg cag att gtc     2679
Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile Val         
            735                 740                 745                 

atc tgt gtg atc tgg ctc tac acc gcg ccc ccc tca agc tac cgc aac     2727
Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg Asn         
        750                 755                 760                     

cag gag ctg gag gat gag atc atc ttc atc acg tgc cac gag ggc tcc     2775
Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly Ser         
    765                 770                 775                         

ctc atg gcc ctg ggc ttc ctg atc ggc tac acc tgc ctg ctg gct gcc     2823
Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala Ala         
780                 785                 790                 795         

atc tgc ttc ttc ttt gcc ttc aag tcc cgg aag ctg ccg gag aac ttc     2871
Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn Phe         
                800                 805                 810             

aat gaa gcc aag ttc atc acc ttc agc atg ctc atc ttc ttc atc gtc     2919
Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile Val         
            815                 820                 825                 

tgg atc tcc ttc att cca gcc tat gcc agc acc tat ggc aag ttt gtc     2967
Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe Val         
        830                 835                 840                     

tct gcc gta gag gtg att gcc atc ctg gca gcc agc ttt ggc ttg ctg     3015
Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu Leu         
    845                 850                 855                         

gcg tgc atc ttc ttc aac aag atc tac atc att ctc ttc aag cca tcc     3063
Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro Ser         
860                 865                 870                 875         

cgc aac acc atc gag gag gtg cgt tgc agc acc gca gct cac gct ttc     3111
Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala Phe         
                880                 885                 890             

aag gtg gct gcc cgg gcc acg ctg cgc cgc agc aac gtc tcc cgc aag     3159
Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg Lys         
            895                 900                 905                 

cgg tcc agc agc ctt gga ggc tcc acg gga tcc acc ccc tcc tcc tcc     3207
Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser Ser         
        910                 915                 920                     

atc agc agc aag agc aac agc gaa gac cca ttc cca cgg ccc gag agg     3255
Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Arg Pro Glu Arg         
    925                 930                 935                         

cag aag cag cag cag ccg ctg gcc cta acc cag caa gag cag cag cag     3303
Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln Gln         
940                 945                 950                 955         

cag ccc ctg acc ctc cca cag cag caa cga tct cag cag cag ccc aga     3351
Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro Arg         
                960                 965                 970             

tgc aag cag aag gtc atc ttt ggc agc ggc acg gtc acc ttc tca ctg     3399
Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser Leu         
            975                 980                 985                 

agc ttt gat gag cct cag aag aac gcc atg gcc cac agg  aat tct acg    3447
Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg  Asn Ser Thr        
        990                 995                 1000                    

cac cag  aac tcc ctg gag gcc  cag aaa agc agc gat  acg ctg acc      3492
His Gln  Asn Ser Leu Glu Ala  Gln Lys Ser Ser Asp  Thr Leu Thr          
    1005                 1010                 1015                      

cga cac  cag cca tta ctc ccg  ctg cag tgc ggg gaa  acg gac tta      3537
Arg His  Gln Pro Leu Leu Pro  Leu Gln Cys Gly Glu  Thr Asp Leu          
    1020                 1025                 1030                      

gat ctg  acc gtc cag gaa aca  ggt ctg caa gga cct  gtg ggt gga      3582
Asp Leu  Thr Val Gln Glu Thr  Gly Leu Gln Gly Pro  Val Gly Gly          
    1035                 1040                 1045                      

gac cag  cgg cca gag gtg gag  gac cct gaa gag ttg  tcc cca gca      3627
Asp Gln  Arg Pro Glu Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala          
    1050                 1055                 1060                      

ctt gta  gtg tcc agt tca cag  agc ttt gtc atc agt  ggt gga ggc      3672
Leu Val  Val Ser Ser Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly          
    1065                 1070                 1075                      

agc act  gtt aca gaa aac gta  gtg aat tca taa aatggaagga            3715
Ser Thr  Val Thr Glu Asn Val  Val Asn Ser                               
    1080                 1085                                           

gaagactggg ctagggagaa tgcagagagg tttcttgggg tcccagggat gaggaatcgc   3775

cccagactcc tttcctctga ggaagaaggg ataatagaca catcaaatgc cccgaattta   3835

gtcacaccat cttaaatgac agtgaattga cccatgttcc ctttaaaatt aaaaaaaaga   3895

agagccttgt gtttctgtgg ttgcatttgt caaagcattg agatctccac ggtcagattt   3955

gctgttcacc cacatctaat gtctcttcct ctgttctatc ccacccaaca gctcagagat   4015

gaaactatgg ctttaaacta ccctccagag tgtgcagact gatgggacat caaatttgcc   4075

accactagag ctgagagtct gaaagacaga atgtcaccag tcctgcccaa tgccttgaca   4135

acagactgaa ttttaaatgt tcacaacata aggagaatgt atctcctcct atttatgaaa   4195

accatatgat attttgtctc ctacctgctg ctgctattat gtaacatcca gaaggtttgc   4255

acccctccta taccatatgt ctggttctgt ccaggacatg atactgatgc catgtttaga   4315

ttccaggatc acaagaatca cctcaaattg ttaggaaggg actgcataaa ccaatgagct   4375

gtatctgtaa ttaatattcc tatatgtagc tttatcctta ggaaaatgct tctgttgtaa   4435

tagtccatgg acaatataaa ctgaaaaatg tcagtctggt ttatataagg cagtattatt   4495

gagctctatt tccccacccc actatcctca ctcccataag ctaagcctta tgtgagcccc   4555

ttcagggact caagggtcca gaagtccctc ccatctctac cccaaagaat tcctgaagcc   4615

agatccaccc tatccctgta cagagtaagt tctcaattat tggcctgcta atagctgcta   4675

gggtaggaaa gcgtggttcc aagaaagatc caccctcaaa tgtcggagct atgttccctc   4735

cagcagtggt attaatactg ccggtcaccc aggctctgga gccagagaga cagaccgggg   4795

ttcaagccat ggcttcgtca tttgcaagct gagtgactgt aggcagggaa ccttaacctc   4855

tctaagccac agcttcttca tctttaaaat aaggataata atcattcctt cccctcagag   4915

ctcttatgtg gattaaacga gataatgtat ataaagtact ttagcctggt acctagcaca   4975

caataagcat tcaataaata ttagttaata ttat                               5009


<210>  12
<211>  1088
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
1               5                   10                  15      


Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 


Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Pro Leu Thr Phe Val Leu Ser Val 
    530                 535                 540                 


Leu Gln Val Pro Phe Ser Asn Cys Ser Arg Asp Cys Leu Ala Gly Thr 
545                 550                 555                 560 


Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr Cys Cys Phe Glu Cys Val 
                565                 570                 575     


Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu Thr Asp Ala Ser Ala Cys 
            580                 585                 590         


Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn Glu Asn His Thr Ser Cys 
        595                 600                 605             


Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp Thr Glu Pro Phe Gly Ile 
    610                 615                 620                 


Ala Leu Thr Leu Phe Ala Val Leu Gly Ile Phe Leu Thr Ala Phe Val 
625                 630                 635                 640 


Leu Gly Val Phe Ile Lys Phe Arg Asn Thr Pro Ile Val Lys Ala Thr 
                645                 650                 655     


Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe Ser Leu Leu Cys Cys Phe 
            660                 665                 670         


Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro Gln Asp Trp Thr Cys Arg 
        675                 680                 685             


Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe Val Leu Cys Ile Ser Cys 
    690                 695                 700                 


Ile Leu Val Lys Thr Asn Arg Val Leu Leu Val Phe Glu Ala Lys Ile 
705                 710                 715                 720 


Pro Thr Ser Phe His Arg Lys Trp Trp Gly Leu Asn Leu Gln Phe Leu 
                725                 730                 735     


Leu Val Phe Leu Cys Thr Phe Met Gln Ile Val Ile Cys Val Ile Trp 
            740                 745                 750         


Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg Asn Gln Glu Leu Glu Asp 
        755                 760                 765             


Glu Ile Ile Phe Ile Thr Cys His Glu Gly Ser Leu Met Ala Leu Gly 
    770                 775                 780                 


Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala Ala Ile Cys Phe Phe Phe 
785                 790                 795                 800 


Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn Phe Asn Glu Ala Lys Phe 
                805                 810                 815     


Ile Thr Phe Ser Met Leu Ile Phe Phe Ile Val Trp Ile Ser Phe Ile 
            820                 825                 830         


Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe Val Ser Ala Val Glu Val 
        835                 840                 845             


Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu Leu Ala Cys Ile Phe Phe 
    850                 855                 860                 


Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro Ser Arg Asn Thr Ile Glu 
865                 870                 875                 880 


Glu Val Arg Cys Ser Thr Ala Ala His Ala Phe Lys Val Ala Ala Arg 
                885                 890                 895     


Ala Thr Leu Arg Arg Ser Asn Val Ser Arg Lys Arg Ser Ser Ser Leu 
            900                 905                 910         


Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser Ser Ile Ser Ser Lys Ser 
        915                 920                 925             


Asn Ser Glu Asp Pro Phe Pro Arg Pro Glu Arg Gln Lys Gln Gln Gln 
    930                 935                 940                 


Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln Gln Gln Pro Leu Thr Leu 
945                 950                 955                 960 


Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro Arg Cys Lys Gln Lys Val 
                965                 970                 975     


Ile Phe Gly Ser Gly Thr Val Thr Phe Ser Leu Ser Phe Asp Glu Pro 
            980                 985                 990         


Gln Lys Asn Ala Met Ala His Arg  Asn Ser Thr His Gln  Asn Ser Leu 
        995                 1000                 1005             


Glu Ala  Gln Lys Ser Ser Asp  Thr Leu Thr Arg His  Gln Pro Leu 
    1010                 1015                 1020             


Leu Pro  Leu Gln Cys Gly Glu  Thr Asp Leu Asp Leu  Thr Val Gln 
    1025                 1030                 1035             


Glu Thr  Gly Leu Gln Gly Pro  Val Gly Gly Asp Gln  Arg Pro Glu 
    1040                 1045                 1050             


Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala Leu Val  Val Ser Ser 
    1055                 1060                 1065             


Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly Ser Thr  Val Thr Glu 
    1070                 1075                 1080             


Asn Val  Val Asn Ser 
    1085             


