               SEQUENCE LISTING

<110> Abbott GmbH & Co. KG
      FUNDACIÓ INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALLD'HEB
      RON, FUNDACIÓ PRIVADA

<120> Method for detection of ischemic strokes

<130> ABBPT10069EPWO

<150> EP10007854.2
<151> 2010-07-28

<160> 5

<170> BiSSAP 1.0

<210> 1
<211> 704
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..704
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Met Ala Arg Glu Leu Arg Ala Leu Leu Leu Trp Gly Arg Arg Leu Arg 
1               5                   10                   15    
Pro Leu Leu Arg Ala Pro Ala Leu Ala Ala Val Pro Gly Gly Lys Pro 
            20                   25                  30        
Ile Leu Cys Pro Arg Arg Thr Thr Ala Gln Leu Gly Pro Arg Arg Asn 
        35                   40                  45            
Pro Ala Trp Ser Leu Gln Ala Gly Arg Leu Phe Ser Thr Gln Thr Ala 
    50                   55                  60                
Glu Asp Lys Glu Glu Pro Leu His Ser Ile Ile Ser Ser Thr Glu Ser 
65                   70                  75                  80
Val Gln Gly Ser Thr Ser Lys His Glu Phe Gln Ala Glu Thr Lys Lys 
                85                   90                  95    
Leu Leu Asp Ile Val Ala Arg Ser Leu Tyr Ser Glu Lys Glu Val Phe 
            100                  105                110        
Ile Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Glu Lys Leu Arg 
        115                  120                125            
His Lys Leu Val Ser Asp Gly Gln Ala Leu Pro Glu Met Glu Ile His 
    130                  135                140                
Leu Gln Thr Asn Ala Glu Lys Gly Thr Ile Thr Ile Gln Asp Thr Gly 
145                  150                155                  160
Ile Gly Met Thr Gln Glu Glu Leu Val Ser Asn Leu Gly Thr Ile Ala 
                165                  170                175    
Arg Ser Gly Ser Lys Ala Phe Leu Asp Ala Leu Gln Asn Gln Ala Glu 
            180                  185                190        
Ala Ser Ser Lys Ile Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala 
        195                  200                205            
Phe Met Val Ala Asp Arg Val Glu Val Tyr Ser Arg Ser Ala Ala Pro 
    210                  215                220                
Gly Ser Leu Gly Tyr Gln Trp Leu Ser Asp Gly Ser Gly Val Phe Glu 
225                  230                235                  240
Ile Ala Glu Ala Ser Gly Val Arg Thr Gly Thr Lys Ile Ile Ile His 
                245                  250                255    
Leu Lys Ser Asp Cys Lys Glu Phe Ser Ser Glu Ala Arg Val Arg Asp 
            260                  265                270        
Val Val Thr Lys Tyr Ser Asn Phe Val Ser Phe Pro Leu Tyr Leu Asn 
        275                  280                285            
Gly Arg Arg Met Asn Thr Leu Gln Ala Ile Trp Met Met Asp Pro Lys 
    290                  295                300                
Asp Val Arg Glu Trp Gln His Glu Glu Phe Tyr Arg Tyr Val Ala Gln 
305                  310                315                  320
Ala His Asp Lys Pro Arg Tyr Thr Leu His Tyr Lys Thr Asp Ala Pro 
                325                  330                335    
Leu Asn Ile Arg Ser Ile Phe Tyr Val Pro Asp Met Lys Pro Ser Met 
            340                  345                350        
Phe Asp Val Ser Arg Glu Leu Gly Ser Ser Val Ala Leu Tyr Ser Arg 
        355                  360                365            
Lys Val Leu Ile Gln Thr Lys Ala Thr Asp Ile Leu Pro Lys Trp Leu 
    370                  375                380                
Arg Phe Ile Arg Gly Val Val Asp Ser Glu Asp Ile Pro Leu Asn Leu 
385                  390                395                  400
Ser Arg Glu Leu Leu Gln Glu Ser Ala Leu Ile Arg Lys Leu Arg Asp 
                405                  410                415    
Val Leu Gln Gln Arg Leu Ile Lys Phe Phe Ile Asp Gln Ser Lys Lys 
            420                  425                430        
Asp Ala Glu Lys Tyr Ala Lys Phe Phe Glu Asp Tyr Gly Leu Phe Met 
        435                  440                445            
Arg Glu Gly Ile Val Thr Ala Thr Glu Gln Glu Val Lys Glu Asp Ile 
    450                  455                460                
Ala Lys Leu Leu Arg Tyr Glu Ser Ser Ala Leu Pro Ser Gly Gln Leu 
465                  470                475                  480
Thr Ser Leu Ser Glu Tyr Ala Ser Arg Met Arg Ala Gly Thr Arg Asn 
                485                  490                495    
Ile Tyr Tyr Leu Cys Ala Pro Asn Arg His Leu Ala Glu His Ser Pro 
            500                  505                510        
Tyr Tyr Glu Ala Met Lys Lys Lys Asp Thr Glu Val Leu Phe Cys Phe 
        515                  520                525            
Glu Gln Phe Asp Glu Leu Thr Leu Leu His Leu Arg Glu Phe Asp Lys 
    530                  535                540                
Lys Lys Leu Ile Ser Val Glu Thr Asp Ile Val Val Asp His Tyr Lys 
545                  550                555                  560
Glu Glu Lys Phe Glu Asp Arg Ser Pro Ala Ala Glu Cys Leu Ser Glu 
                565                  570                575    
Lys Glu Thr Glu Glu Leu Met Ala Trp Met Arg Asn Val Leu Gly Ser 
            580                  585                590        
Arg Val Thr Asn Val Lys Val Thr Leu Arg Leu Asp Thr His Pro Ala 
        595                  600                605            
Met Val Thr Val Leu Glu Met Gly Ala Ala Arg His Phe Leu Arg Met 
    610                  615                620                
Gln Gln Leu Ala Lys Thr Gln Glu Glu Arg Ala Gln Leu Leu Gln Pro 
625                  630                635                  640
Thr Leu Glu Ile Asn Pro Arg His Ala Leu Ile Lys Lys Leu Asn Gln 
                645                  650                655    
Leu Arg Ala Ser Glu Pro Gly Leu Ala Gln Leu Leu Val Asp Gln Ile 
            660                  665                670        
Tyr Glu Asn Ala Met Ile Ala Ala Gly Leu Val Asp Asp Pro Arg Ala 
        675                  680                685            
Met Val Gly Arg Leu Asn Glu Leu Leu Val Lys Ala Leu Glu Arg His 
    690                  695                700                

<210> 2
<211> 418
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..418
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 2
Met Phe Ser Pro Asp Gln Glu Asn His Pro Ser Lys Ala Pro Val Lys 
1               5                   10                   15    
Tyr Gly Glu Leu Ile Val Leu Gly Tyr Asn Gly Ser Leu Pro Asn Gly 
            20                   25                  30        
Asp Arg Gly Arg Arg Lys Ser Arg Phe Ala Leu Phe Lys Arg Pro Lys 
        35                   40                  45            
Ala Asn Gly Val Lys Pro Ser Thr Val His Ile Ala Cys Thr Pro Gln 
    50                   55                  60                
Ala Ala Lys Ala Ile Ser Asn Lys Asp Gln His Ser Ile Ser Tyr Thr 
65                   70                  75                  80
Leu Ser Arg Ala Gln Thr Val Val Val Glu Tyr Thr His Asp Ser Asn 
                85                   90                  95    
Thr Asp Met Phe Gln Ile Gly Arg Ser Thr Glu Ser Pro Ile Asp Phe 
            100                  105                110        
Val Val Thr Asp Thr Val Pro Gly Ser Gln Ser Asn Ser Asp Thr Gln 
        115                  120                125            
Ser Val Gln Ser Thr Ile Ser Arg Phe Ala Cys Arg Ile Ile Cys Glu 
    130                  135                140                
Arg Asn Pro Pro Phe Thr Ala Arg Ile Tyr Ala Ala Gly Phe Asp Ser 
145                  150                155                  160
Ser Lys Asn Ile Phe Leu Gly Glu Lys Ala Ala Lys Trp Lys Thr Ser 
                165                  170                175    
Asp Gly Gln Met Asp Gly Leu Thr Thr Asn Gly Val Leu Val Met His 
            180                  185                190        
Pro Arg Asn Gly Phe Thr Glu Asp Ser Lys Pro Gly Ile Trp Arg Glu 
        195                  200                205            
Ile Ser Val Cys Gly Asn Val Phe Ser Leu Arg Glu Thr Arg Ser Ala 
    210                  215                220                
Gln Gln Arg Gly Lys Met Val Glu Ile Glu Thr Asn Gln Leu Gln Asp 
225                  230                235                  240
Gly Ser Leu Ile Asp Leu Cys Gly Ala Thr Leu Leu Trp Arg Thr Ala 
                245                  250                255    
Glu Gly Leu Ser His Thr Pro Thr Val Lys His Leu Glu Ala Leu Arg 
            260                  265                270        
Gln Glu Ile Asn Ala Ala Arg Pro Gln Cys Pro Val Gly Phe Asn Thr 
        275                  280                285            
Leu Ala Phe Pro Ser Met Lys Arg Lys Asp Val Val Asp Glu Lys Gln 
    290                  295                300                
Pro Trp Val Tyr Leu Asn Cys Gly His Val His Gly Tyr His Asn Trp 
305                  310                315                  320
Gly Asn Lys Glu Glu Arg Asp Gly Lys Asp Arg Glu Cys Pro Met Cys 
                325                  330                335    
Arg Ser Val Gly Pro Tyr Val Pro Leu Trp Leu Gly Cys Glu Ala Gly 
            340                  345                350        
Phe Tyr Val Asp Ala Gly Pro Pro Thr His Ala Phe Ser Pro Cys Gly 
        355                  360                365            
His Val Cys Ser Glu Lys Thr Thr Ala Tyr Trp Ser Gln Ile Pro Leu 
    370                  375                380                
Pro His Gly Thr His Thr Phe His Ala Ala Cys Pro Phe Cys Ala His 
385                  390                395                  400
Gln Leu Ala Gly Glu Gln Gly Tyr Ile Arg Leu Ile Phe Gln Gly Pro 
                405                  410                415    
Leu Asp 
        

<210> 3
<211> 828
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..828
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 3
Met Ala Glu Ala Ala Leu Leu Leu Leu Pro Glu Ala Ala Ala Glu Arg 
1               5                   10                   15    
Asp Ala Arg Glu Lys Leu Ala Leu Trp Asp Arg Arg Pro Asp Thr Thr 
            20                   25                  30        
Ala Pro Leu Thr Asp Arg Gln Thr Asp Ser Val Leu Glu Leu Lys Ala 
        35                   40                  45            
Ala Ala Glu Asn Leu Pro Val Pro Ala Glu Leu Pro Ile Glu Asp Leu 
    50                   55                  60                
Cys Ser Leu Thr Ser Gln Ser Leu Pro Ile Glu Leu Thr Ser Val Val 
65                   70                  75                  80
Pro Glu Ser Thr Glu Asp Ile Leu Leu Lys Gly Phe Thr Ser Leu Gly 
                85                   90                  95    
Met Glu Glu Glu Arg Ile Glu Thr Ala Gln Gln Phe Phe Ser Trp Phe 
            100                  105                110        
Ala Lys Leu Gln Thr Gln Met Asp Gln Asp Glu Gly Thr Lys Tyr Arg 
        115                  120                125            
Gln Met Arg Asp Tyr Leu Ser Gly Phe Gln Glu Gln Cys Asp Ala Ile 
    130                  135                140                
Leu Asn Asp Val Asn Ser Ala Leu Gln His Leu Glu Ser Leu Gln Lys 
145                  150                155                  160
Gln Tyr Leu Phe Val Ser Asn Lys Thr Gly Thr Leu His Glu Ala Cys 
                165                  170                175    
Glu Gln Leu Leu Lys Glu Gln Ser Glu Leu Val Asp Leu Ala Glu Asn 
            180                  185                190        
Ile Gln Gln Lys Leu Ser Tyr Phe Asn Glu Leu Glu Thr Ile Asn Thr 
        195                  200                205            
Lys Leu Asn Ser Pro Thr Leu Ser Val Asn Ser Asp Gly Phe Ile Pro 
    210                  215                220                
Met Leu Ala Lys Leu Asp Asp Cys Ile Thr Tyr Ile Ser Ser His Pro 
225                  230                235                  240
Asn Phe Lys Asp Tyr Pro Ile Tyr Leu Leu Lys Phe Lys Gln Cys Leu 
                245                  250                255    
Ser Lys Ala Leu His Leu Met Lys Thr Tyr Thr Val Asn Thr Leu Gln 
            260                  265                270        
Thr Leu Thr Ser Gln Leu Leu Lys Arg Asp Pro Ser Ser Val Pro Asn 
        275                  280                285            
Ala Asp Asn Ala Phe Thr Leu Phe Tyr Val Lys Phe Arg Ala Ala Ala 
    290                  295                300                
Pro Lys Val Arg Thr Leu Ile Glu Gln Ile Glu Leu Arg Ser Glu Lys 
305                  310                315                  320
Ile Pro Glu Tyr Gln Gln Leu Leu Asn Asp Ile His Gln Cys Tyr Leu 
                325                  330                335    
Asp Gln Arg Glu Leu Leu Leu Gly Pro Ser Ile Ala Cys Thr Val Ala 
            340                  345                350        
Glu Leu Thr Ser Gln Asn Asn Arg Asp His Cys Ala Leu Val Arg Ser 
        355                  360                365            
Gly Cys Ala Phe Met Val His Val Cys Gln Asp Glu His Gln Leu Tyr 
    370                  375                380                
Asn Glu Phe Phe Thr Lys Pro Thr Ser Lys Leu Asp Glu Leu Leu Glu 
385                  390                395                  400
Lys Leu Cys Val Ser Leu Tyr Asp Val Phe Arg Pro Leu Ile Ile His 
                405                  410                415    
Val Ile His Leu Glu Thr Leu Ser Glu Leu Cys Gly Ile Leu Lys Asn 
            420                  425                430        
Glu Val Leu Glu Asp His Val Gln Asn Asn Ala Glu Gln Leu Gly Ala 
        435                  440                445            
Phe Ala Ala Gly Val Lys Gln Met Leu Glu Asp Val Gln Glu Arg Leu 
    450                  455                460                
Val Tyr Arg Thr His Ile Tyr Ile Gln Thr Asp Ile Thr Gly Tyr Lys 
465                  470                475                  480
Pro Ala Pro Gly Asp Leu Ala Tyr Pro Asp Lys Leu Val Met Met Glu 
                485                  490                495    
Gln Ile Ala Gln Ser Leu Lys Asp Glu Gln Lys Lys Val Pro Ser Glu 
            500                  505                510        
Ala Ser Phe Ser Asp Val His Leu Glu Glu Gly Glu Ser Asn Ser Leu 
        515                  520                525            
Thr Lys Ser Gly Ser Thr Glu Ser Leu Asn Pro Arg Pro Gln Thr Thr 
    530                  535                540                
Ile Ser Pro Ala Asp Leu His Gly Met Trp Tyr Pro Thr Val Arg Arg 
545                  550                555                  560
Thr Leu Val Cys Leu Ser Lys Leu Tyr Arg Cys Ile Asp Arg Ala Val 
                565                  570                575    
Phe Gln Gly Leu Ser Gln Glu Ala Leu Ser Ala Cys Ile Gln Ser Leu 
            580                  585                590        
Leu Gly Ala Ser Glu Ser Ile Ser Lys Asn Lys Thr Gln Ile Asp Gly 
        595                  600                605            
Gln Leu Phe Leu Ile Lys His Leu Leu Ile Leu Arg Glu Gln Ile Ala 
    610                  615                620                
Pro Phe His Thr Glu Phe Thr Ile Lys Glu Ile Ser Leu Asp Leu Lys 
625                  630                635                  640
Lys Thr Arg Asp Ala Ala Phe Lys Ile Leu Asn Pro Met Thr Val Pro 
                645                  650                655    
Arg Phe Phe Arg Leu Asn Ser Asn Asn Ala Leu Ile Glu Phe Leu Leu 
            660                  665                670        
Glu Gly Thr Pro Glu Ile Arg Glu His Tyr Leu Asp Ser Lys Lys Asp 
        675                  680                685            
Val Asp Arg His Leu Lys Ser Ala Cys Glu Gln Phe Ile Gln Gln Gln 
    690                  695                700                
Thr Lys Leu Phe Val Glu Gln Leu Glu Glu Phe Met Thr Lys Val Ser 
705                  710                715                  720
Ala Leu Lys Thr Met Ala Ser Gln Gly Gly Pro Lys Tyr Thr Leu Ser 
                725                  730                735    
Gln Gln Pro Trp Ala Gln Pro Ala Lys Val Asn Asp Leu Ala Ala Thr 
            740                  745                750        
Ala Tyr Lys Thr Ile Lys Thr Lys Leu Pro Val Thr Leu Arg Ser Met 
        755                  760                765            
Ser Leu Tyr Leu Ser Asn Lys Asp Thr Glu Phe Ile Leu Phe Lys Pro 
    770                  775                780                
Val Arg Asn Asn Ile Gln Gln Val Phe Gln Lys Phe His Ala Leu Leu 
785                  790                795                  800
Lys Glu Glu Phe Ser Pro Glu Asp Ile Gln Ile Ile Ala Cys Pro Ser 
                805                  810                815    
Met Glu Gln Leu Ser Leu Leu Leu Ser Val Ser Lys 
            820                  825            

<210> 4
<211> 504
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..504
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 4
Met Glu Ala Pro Leu Gln Thr Glu Met Val Glu Leu Val Pro Asn Gly 
1               5                   10                   15    
Lys His Ser Glu Gly Leu Leu Pro Val Ile Thr Pro Met Ala Gly Asn 
            20                   25                  30        
Gln Arg Val Glu Asp Pro Ala Arg Ser Cys Met Glu Gly Lys Ser Phe 
        35                   40                  45            
Leu Gln Lys Ser Pro Ser Lys Glu Pro His Phe Thr Asp Phe Glu Gly 
    50                   55                  60                
Lys Thr Ser Phe Gly Met Ser Val Phe Asn Leu Ser Asn Ala Ile Met 
65                   70                  75                  80
Gly Ser Gly Ile Leu Gly Leu Ala Tyr Ala Met Ala Asn Thr Gly Ile 
                85                   90                  95    
Ile Leu Phe Leu Phe Leu Leu Thr Ala Val Ala Leu Leu Ser Ser Tyr 
            100                  105                110        
Ser Ile His Leu Leu Leu Lys Ser Ser Gly Val Val Gly Ile Arg Ala 
        115                  120                125            
Tyr Glu Gln Leu Gly Tyr Arg Ala Phe Gly Thr Pro Gly Lys Leu Ala 
    130                  135                140                
Ala Ala Leu Ala Ile Thr Leu Gln Asn Ile Gly Ala Met Ser Ser Tyr 
145                  150                155                  160
Leu Tyr Ile Ile Lys Ser Glu Leu Pro Leu Val Ile Gln Thr Phe Leu 
                165                  170                175    
Asn Leu Glu Glu Lys Thr Ser Asp Trp Tyr Met Asn Gly Asn Tyr Leu 
            180                  185                190        
Val Ile Leu Val Ser Val Thr Ile Ile Leu Pro Leu Ala Leu Met Arg 
        195                  200                205            
Gln Leu Gly Tyr Leu Gly Tyr Ser Ser Gly Phe Ser Leu Ser Cys Met 
    210                  215                220                
Val Phe Phe Leu Ile Ala Val Ile Tyr Lys Lys Phe His Val Pro Cys 
225                  230                235                  240
Pro Leu Pro Pro Asn Phe Asn Asn Thr Thr Gly Asn Phe Ser His Val 
                245                  250                255    
Glu Ile Val Lys Glu Lys Val Gln Leu Gln Val Glu Pro Glu Ala Ser 
            260                  265                270        
Ala Phe Cys Thr Pro Ser Tyr Phe Thr Leu Asn Ser Gln Thr Ala Tyr 
        275                  280                285            
Thr Ile Pro Ile Met Ala Phe Ala Phe Val Cys His Pro Glu Val Leu 
    290                  295                300                
Pro Ile Tyr Thr Glu Leu Lys Asp Pro Ser Lys Lys Lys Met Gln His 
305                  310                315                  320
Ile Ser Asn Leu Ser Ile Ala Val Met Tyr Ile Met Tyr Phe Leu Ala 
                325                  330                335    
Ala Leu Phe Gly Tyr Leu Thr Phe Tyr Asn Gly Val Glu Ser Glu Leu 
            340                  345                350        
Leu His Thr Tyr Ser Lys Val Asp Pro Phe Asp Val Leu Ile Leu Cys 
        355                  360                365            
Val Arg Val Ala Val Leu Thr Ala Val Thr Leu Thr Val Pro Ile Val 
    370                  375                380                
Leu Phe Pro Val Arg Arg Ala Ile Gln Gln Met Leu Phe Pro Asn Gln 
385                  390                395                  400
Glu Phe Ser Trp Leu Arg His Val Leu Ile Ala Val Gly Leu Leu Thr 
                405                  410                415    
Cys Ile Asn Leu Leu Val Ile Phe Ala Pro Asn Ile Leu Gly Ile Phe 
            420                  425                430        
Gly Val Ile Gly Ala Thr Ser Ala Pro Phe Leu Ile Phe Ile Phe Pro 
        435                  440                445            
Ala Ile Phe Tyr Phe Arg Ile Met Pro Thr Glu Lys Glu Pro Ala Arg 
    450                  455                460                
Ser Thr Pro Lys Ile Leu Ala Leu Cys Phe Ala Met Leu Gly Phe Leu 
465                  470                475                  480
Leu Met Thr Met Ser Leu Ser Phe Ile Ile Ile Asp Trp Ala Ser Gly 
                485                  490                495    
Thr Ser Arg His Gly Gly Asn His 
            500                

<210> 5
<211> 694
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..694
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 5
Met Gln Pro Ala Ile Gln Val Trp Phe Gly Glu Asp Leu Pro Leu Ser 
1               5                   10                   15    
Pro Arg Ser Pro Leu Thr Pro Arg His Gly Pro Gly Leu Ala Asn Val 
            20                   25                  30        
Cys Gln Tyr Asp Glu Trp Ile Ala Val Arg His Glu Ala Thr Leu Leu 
        35                   40                  45            
Pro Met Gln Glu Asp Leu Ser Ile Trp Leu Ser Gly Leu Leu Gly Ile 
    50                   55                  60                
Lys Val Lys Ala Glu Lys Leu Leu Glu Glu Leu Asp Asn Gly Val Leu 
65                   70                  75                  80
Leu Cys Gln Leu Ile Asp Val Leu Gln Asn Met Val Lys Thr Cys Asn 
                85                   90                  95    
Ser Glu Glu Ser Gly Asn Phe Pro Met Arg Lys Val Pro Cys Lys Lys 
            100                  105                110        
Asp Ala Ala Ser Gly Ser Phe Phe Ala Arg Asp Asn Thr Ala Asn Phe 
        115                  120                125            
Leu His Trp Cys Arg Asp Ile Gly Val Asp Glu Thr Tyr Leu Phe Glu 
    130                  135                140                
Ser Glu Gly Leu Val Leu His Lys Asp Pro Arg Gln Val Tyr Leu Cys 
145                  150                155                  160
Leu Leu Glu Ile Gly Arg Ile Val Ser Arg Tyr Gly Val Glu Pro Pro 
                165                  170                175    
Val Leu Val Lys Leu Glu Lys Glu Ile Glu Leu Glu Glu Thr Leu Leu 
            180                  185                190        
Asn Thr Ser Gly Pro Glu Asp Ser Ile Ser Ile Pro Lys Ser Cys Cys 
        195                  200                205            
Arg His Glu Glu Leu His Glu Ala Val Lys His Ile Ala Glu Asp Pro 
    210                  215                220                
Pro Cys Ser Cys Ser His Arg Phe Ser Ile Glu Tyr Leu Ser Glu Gly 
225                  230                235                  240
Arg Tyr Arg Leu Gly Asp Lys Ile Leu Phe Ile Arg Met Leu His Gly 
                245                  250                255    
Lys His Val Met Val Arg Val Gly Gly Gly Trp Asp Thr Leu Gln Gly 
            260                  265                270        
Phe Leu Leu Lys Tyr Asp Pro Cys Arg Ile Leu Gln Phe Ala Thr Leu 
        275                  280                285            
Glu Gln Lys Ile Leu Ala Phe Gln Lys Gly Val Ser Asn Glu Ser Val 
    290                  295                300                
Pro Asp Ser Pro Ala Arg Thr Pro Gln Pro Pro Glu Met Asn Pro Leu 
305                  310                315                  320
Ser Ala Val Asn Met Phe Gln Lys Gln Asn Ser Lys Pro Ser Val Pro 
                325                  330                335    
Val Ser Ile Pro Lys Ser Lys Glu Lys Gln Gly Arg Pro Pro Gly Ala 
            340                  345                350        
Leu Val Pro Ala Ser Ser Leu Lys Gly Gly Asn Leu Gly Ser Met Ser 
        355                  360                365            
Val Arg Ser Lys Leu Pro Asn Ser Pro Ala Ala Ser Ser His Pro Lys 
    370                  375                380                
Leu Lys Ser Ser Lys Gly Ile Thr Lys Lys Pro Gln Ala Pro Ser Asn 
385                  390                395                  400
Asn Ala Ser Ser Ser Leu Ala Ser Leu Asn Pro Val Gly Lys Asn Thr 
                405                  410                415    
Ser Ser Pro Ala Leu Pro Arg Thr Ala Pro Cys Ile Ser Glu Ser Pro 
            420                  425                430        
Arg Lys Cys Ile Ser Ser Pro Asn Thr Pro Lys Ala Lys Val Ile Pro 
        435                  440                445            
Ala Gln Asn Ser Ala Asp Leu Pro Glu Ser Thr Leu Leu Pro Asn Lys 
    450                  455                460                
Cys Ser Gly Lys Thr Gln Pro Lys Tyr Leu Lys His Asn His Ile Ser 
465                  470                475                  480
Ser Arg Asp Asn Ala Val Ser His Leu Ala Ala His Ser Asn Ser Ser 
                485                  490                495    
Ser Lys Cys Pro Lys Leu Pro Lys Ala Asn Ile Pro Val Arg Pro Lys 
            500                  505                510        
Pro Ser Phe Gln Ser Ser Ala Lys Met Thr Lys Thr Ser Ser Lys Thr 
        515                  520                525            
Ile Ala Thr Gly Leu Gly Thr Gln Ser Gln Pro Ser Asp Gly Ala Pro 
    530                  535                540                
Gln Ala Lys Pro Val Pro Ala Gln Lys Leu Lys Ser Ala Leu Asn Leu 
545                  550                555                  560
Asn Gln Pro Val Ser Val Ser Ser Val Ser Pro Val Lys Ala Thr Gln 
                565                  570                575    
Lys Ser Lys Asp Lys Asn Ile Val Ser Ala Thr Lys Lys Gln Pro Gln 
            580                  585                590        
Asn Lys Ser Ala Phe Gln Lys Thr Gly Pro Ser Ser Leu Lys Ser Pro 
        595                  600                605            
Gly Arg Thr Pro Leu Ser Ile Val Ser Leu Pro Gln Ser Ser Thr Lys 
    610                  615                620                
Thr Gln Thr Ala Pro Lys Ser Ala Gln Thr Val Ala Lys Ser Gln His 
625                  630                635                  640
Ser Thr Lys Gly Pro Pro Arg Ser Gly Lys Thr Pro Ala Ser Ile Arg 
                645                  650                655    
Lys Pro Pro Ser Ser Val Lys Asp Ala Asp Ser Gly Asp Lys Lys Pro 
            660                  665                670        
Thr Ala Lys Lys Lys Glu Asp Asp Asp His Tyr Phe Val Met Thr Gly 
        675                  680                685            
Ser Lys Lys Pro Arg Lys 
    690                

