                               SEQUENCE LISTING	

<110> SHIRE HUMAN GENETIC THERAPIES, INC.
 
<120> MANNOSE RECEPTOR C TYPE 1 (MRC1) CODON OPTIMIZED CELL LINE AND 
      USES THEREOF

<130> S2071-7039WO

<140>
<141>

<150> 61/365,755
<151> 2010-07-19

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 4371
<212> DNA
<213> Homo sapiens

<400> 1
atgaggctac ccctgctcct ggtttttgcc tctgtcattc cgggtgctgt tctcctactg       60

gacaccaggc aatttttaat ctataatgaa gatcacaagc gctgcgtgga tgcagtgagt      120

cccagtgccg tccaaaccgc agcttgcaac caggatgccg aatcacagaa attccgatgg      180

gtgtccgaat ctcagattat gagtgttgca tttaaattat gcctgggagt gccatcaaaa      240

acagactggg ttgctatcac tctctatgcc tgtgactcaa aaagtgaatt tcagaaatgg      300

gagtgcaaaa atgacacact tttggggatc aaaggagaag atttattttt taactacggc      360

aacagacaag aaaagaatat tatgctctac aagggatcgg gtttatggag caggtggaag      420

atctatggaa ccacagacaa tctgtgctcc agaggttatg aagccatgta tacgctacta      480

ggcaatgcca atggagcaac ctgtgcattc ccgttcaagt ttgaaaacaa gtggtacgca      540

gattgcacga gtgctgggcg gtcggatgga tggctctggt gcggaaccac tactgactat      600

gacacagaca agctatttgg atattgtcca ttgaaatttg agggcagtga aagcttatgg      660

aataaagacc cgctgaccag cgtttcctac cagataaact ccaaatccgc tttaacgtgg      720

caccaagcga ggaaaagctg ccaacaacag aacgctgagc tcctgagcat cacagagata      780

catgagcaaa catacctgac aggattaacc agttccttga cctcaggact ctggattgga      840

cttaacagtc tgagcttcaa cagcggttgg cagtggagtg accgcagtcc tttccgatat      900

ttgaactggt taccaggaag tccatcagct gaacctggaa aaagctgtgt gtcactaaat      960

cctggaaaaa atgctaaatg ggaaaatctg gaatgtgttc agaaactggg ctatatttgc     1020

aaaaagggca acaccacttt aaattctttt gttattccct cagaaagtga tgtgcctact     1080

cactgtccta gtcagtggtg gccgtatgcc ggtcactgtt acaagattca cagagatgag     1140

aaaaaaatcc agagggatgc tctgaccacc tgcaggaagg aaggcggtga cctcacaagt     1200

atccacacca tcgaggaatt ggactttatt atctcccagc taggatatga gccaaatgac     1260

gaattgtgga tcggcttaaa tgacattaag attcaaatgt actttgagtg gagtgatggg     1320

acccctgtaa cgtttaccaa atggcttcgt ggagaaccaa gccatgaaaa caacagacag     1380

gaggattgtg tggtgatgaa aggcaaggat gggtactggg cagatcgggg ctgtgagtgg     1440

cctcttggct acatctgcaa gatgaaatca cgaagccaag gtccagaaat agtggaagtc     1500

gaaaaaggct gcaggaaagg ctggaaaaaa catcactttt actgctatat gattggacat     1560

acgctttcaa catttgcaga agcaaaccaa acctgtaata atgagaatgc ttatttaaca     1620

actattgaag acagatatga acaagccttc ctgactagtt tcgttggctt aaggcctgaa     1680

aaatatttct ggacaggact ttcagatata caaaccaaag ggacttttca gtggaccatc     1740

gaggaagagg ttcggttcac ccactggaat tcagatatgc cagggcgaaa gccagggtgt     1800

gttgccatga gaaccgggat tgcagggggc ttatgggatg ttttgaaatg tgatgaaaag     1860

gcaaaatttg tgtgcaagca ctgggcagaa ggagtaaccc acccaccgaa gcccacgacg     1920

actcccgaac ccaaatgtcc ggaggattgg ggcgccagca gtagaacaag cttgtgtttc     1980

aagctgtatg caaaaggaaa acatgagaag aaaacgtggt ttgaatctcg agatttttgt     2040

cgagctctgg gtggagactt agctagcatc aataacaaag aggaacagca aacaatatgg     2100

cgattaataa cagctagtgg aagctaccac aaactgtttt ggttgggatt gacatatgga     2160

agcccttcag aaggttttac ttggagtgat ggttctcctg tttcatatga aaactgggct     2220

tatggagaac ctaataatta tcaaaatgtt gaatactgtg gtgagctgaa aggtgaccct     2280

actatgtctt ggaatgatat taattgtgaa caccttaaca actggatttg ccagatacaa     2340

aaaggacaaa caccaaaacc tgagccaaca ccagctcctc aagacaatcc accagttact     2400

gaagatgggt gggttattta caaagactac cagtattatt tcagcaaaga gaaggaaacc     2460

atggacaatg cgcgagcgtt ttgcaagagg aattttggtg atcttgtttc tattcaaagt     2520

gaaagtgaaa agaagtttct atggaaatat gtaaacagaa atgatgcaca gtctgcatat     2580

tttattggtt tattgatcag cttggataaa aagtttgctt ggatggatgg aagcaaagtg     2640

gattacgtgt cttgggccac aggtgaaccc aattttgcaa atgaagatga aaactgtgtg     2700

accatgtatt caaattcagg gttttggaat gacattaact gtggctatcc aaacgccttc     2760

atttgccagc gacataacag tagtatcaat gctaccacag ttatgcctac catgccctcg     2820

gtcccatcag ggtgcaagga aggttggaat ttctacagca acaagtgttt caaaatcttt     2880

ggatttatgg aagaagaaag aaaaaattgg caagaggcac gaaaagcttg tataggcttt     2940

ggagggaatc tggtctccat acaaaatgaa aaagagcaag catttcttac ctatcacatg     3000

aaggactcca ctttcagtgc ctggactggg ctgaatgatg tcaattcaga acacacgttc     3060

ctttggacgg atggacgagg agtccattac acaaactggg ggaaaggtta ccctggtgga     3120

agaagaagca gtctttctta tgaagatgct gactgtgttg ttattattgg aggtgcatca     3180

aatgaagcag gaaaatggat ggatgatacc tgcgacagta aacgaggcta catatgccag     3240

acacgatccg acccttcctt gactaatcct ccagcaacga ttcaaacaga tggctttgtt     3300

aaatatggca aaagcagcta ttcactcatg agacaaaaat ttcaatggca tgaagcggag     3360

acatactgca agcttcacaa ttcccttata gccagcattc tggatcccta cagtaatgca     3420

tttgcgtggc tgcagatgga aacatctaat gaacgtgtgt ggatcgccct gaacagtaac     3480

ttgactgata atcaatacac ttggactgat aagtggaggg tgaggtacac taactgggct     3540

gctgatgagc ccaaattgaa atcagcatgt gtttatctgg atcttgatgg ctactggaag     3600

acagcacatt gcaatgaaag tttttacttt ctctgtaaaa gatcagatga aatccctgct     3660

actgaacccc cacaactgcc tggcagatgc ccggagtcag atcacacagc atggattcct     3720

ttccatggtc actgttacta tattgagtcc tcatatacaa gaaactgggg ccaagcttct     3780

ctggaatgtc ttcgaatggg ttcctctctg gtttccattg aaagtgctgc agaatccagt     3840

tttctgtcat atcgggttga gccacttaaa agtaaaacca atttttggat aggattgttc     3900

agaaatgttg aagggacgtg gctgtggata aataacagtc cggtctcctt tgtcaactgg     3960

aacacaggag atccctctgg tgaacggaat gattgtgtag ctttacatgc gtcttctggg     4020

ttttggagta atattcactg ttcatcctac aaaggatata tttgtaaaag accaaaaatt     4080

attgatgcta aacctactca tgaattactt acaacaaaag ctgacacaag gaagatggac     4140

ccttctaaac cgtcttccaa cgtggccgga gtagtcatca ttgtgatcct cctgatttta     4200

acgggtgctg gccttgccgc ctatttcttt tataagaaaa gacgtgtgca cctacctcaa     4260

gagggcgcct ttgaaaacac tctgtatttt aacagtcagt caagcccagg aactagtgat     4320

atgaaagatc tcgtgggcaa tattgaacag aatgaacact cggtcatcta g              4371


<210> 2
<211> 2067
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atgagactgc ccctgctgct ggtgttcgcc agcgtgatcc ccggcgccgt gctgctgctg       60

gacaccagac agttcctgat ctacaacgag gaccacaaga gatgcgtgga cgccgtgagc      120

cccagcgccg tgcagaccgc cgcctgcaac caggacgccg agagccagaa gttcagatgg      180

gtgagcgaga gccagatcat gagcgtggcc ttcaagctgt gcctgggcgt gcccagcaag      240

accgactggg tggccatcac cctgtacgcc tgcgacagca agagcgagtt ccagaagtgg      300

gagtgcaaga acgacaccct gctgggcatc aagggcgagg acctgttctt caactacggc      360

aacagacagg agaagaacat catgctgtac aagggcagcg gcctgtggag cagatggaag      420

atctacggca ccaccgacaa cctgtgcagc agaggctacg aggccatgta caccctgctg      480

ggcaacgcca acggcgccac ctgcgccttc cccttcaagt tcgagaacaa gtggtacgcc      540

gactgcacca gcgccggcag aagcgacggc tggctgtggt gcggcaccac caccgactac      600

gacaccgaca agctgttcgg ctactgcccc ctgaagttcg agggcagcga gagcctgtgg      660

aacaaggacc ccctgaccag cgtgagctac cagatcaaca gcaagagcgc cctgagctgg      720

caccaggcca gaaagagctg ccagcagcag aacgccgagc tgctgagcat caccgagatc      780

cacgagcaga cctacctgac cggcctgacc agcagcctga ccagcggcct gtggatcggc      840

ctgaacagcc tgagcttcaa cagcggctgg cagtggagcg acagaagccc cttcagatac      900

ctgaactggc tgcccggcag ccccagcgcc gagcccggca agagctgcgt gagcctgaac      960

cccggcaaga acgccaagtg ggagaacctg gagtgcgtgc agaagctggg ctacatctgc     1020

aagaagggca acaccaccct gaacagcttc gtgatcccca gcgagagcga cgtgcccacc     1080

cactgcccca gccagtggtg gccctacgcc ggccactgct acaagatcca cagagacgag     1140

aagaagatcc agagagacgc cctgaccacc tgcagaaagg agggcggcga cctggccagc     1200

atccacacca tcgaggagtt cgacttcatc atcagccagc tgggctacga gcccaacgac     1260

gagctgtgga tcggcctgaa cgacatcaag atccagatgt acttcgagtg gagcgacggc     1320

acccccgtga ccttcaccaa gtggctgaga ggcgagccca gccacgagaa caacagacag     1380

gaggactgcg tggtgatgaa gggcaaggac ggctactggg ccgacagagg ctgcgagtgg     1440

cccctgggct acatctgcaa gatgaagagc agaagccagg gccccgagat cgtggaggtg     1500

gagaagggct gcagaaaggg ctggaagaag caccacttct actgctacat gatcggccac     1560

accctgagca ccttcgccga ggccaaccag acctgcaaca acgagaacgc ctacctgacc     1620

accatcgagg acagatacga gcaggccttc ctgaccagct tcgtgggcct gagacccgag     1680

aagtacttct ggaccggcct gagcgacatc cagaccaagg gcaccttcca gtggaccatc     1740

gaggaggagg tgagattcac ccactggaac agcgacatgc ccggcagaaa gcccggctgc     1800

gtggccatga gaaccggcat cgccggcggc ctgtgggacg tgctgaagtg cgacgagaag     1860

gccaagttcg tgtgcaagca ctgggccgag ggcgtgaccc acccccccaa gcccaccacc     1920

acccccgagc ccaagtgccc cgaggactgg ggcgccagca gcagaaccag cctgtgcttc     1980

aagctgtacg ccaagggcaa gatcgagaag aagacctggt tcgagagcag agacttctgc     2040

agagccctgg gcggcgacct ggctagc                                         2067


<210> 3
<211> 2067
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgagactgc ccctgctgct ggtgttcgcc agcgtgatcc ccggcgccgt gctgctgctg       60

gacaccagac agttcctgat ctacaacgag gaccacaaga gatgcgtgga cgccgtgagc      120

cccagcgccg tgcagaccgc cgcctgtaat caagacgcag agagccagaa gttcagatgg      180

gtgagcgaga gccagatcat gagcgtggcc ttcaagctgt gcctgggcgt gcccagcaag      240

accgactggg tggccatcac cctgtacgcc tgcgacagca agagcgagtt ccagaagtgg      300

gagtgcaaga acgacaccct gctgggcatc aagggcgagg acctgttctt caactacggc      360

aacagacagg agaagaacat catgctgtac aagggcagcg gcctgtggag cagatggaag      420

atctacggca ccaccgacaa cctgtgcagc agaggctacg aggccatgta caccctgctg      480

ggcaacgcca acggcgccac ctgcgccttc cccttcaagt tcgagaacaa gtggtacgcc      540

gactgcacca gcgccggcag aagcgacggc tggctgtggt gcggcaccac caccgactac      600

gacaccgaca agctgttcgg ctactgcccc ctgaagttcg agggcagcga gagcctgtgg      660

aacaaggacc ccctgaccag cgtgagctac cagatcaaca gcaagagcgc cctgacctgg      720

caccaggcca gaaagagctg ccagcagcag aacgccgagc tgctgagcat caccgagatc      780

cacgagcaga cctacctgac cggcctgacc agcagcctga ccagcggcct gtggatcggc      840

ctgaacagcc tgagcttcaa cagcggctgg cagtggagcg acagaagccc cttcagatac      900

ctgaactggc tgcccggcag ccccagcgcc gagcccggca agagctgcgt gagcctgaac      960

cccggcaaga acgccaagtg ggagaacctg gagtgcgtgc agaagctggg ctacatctgc     1020

aagaagggca acaccaccct gaacagcttc gtgatcccca gcgagagcga cgtgcccacc     1080

cactgcccca gccagtggtg gccctacgcc ggccactgct acaagatcca cagagacgag     1140

aagaagatcc agagagacgc cctgaccacc tgcagaaagg agggcggcga cctgaccagc     1200

atccacacca tcgaggagct ggacttcatc atcagccagc tgggctacga gcccaacgac     1260

gagctgtgga tcggcctgaa cgacatcaag atccagatgt acttcgagtg gagcgacggc     1320

acccccgtga ccttcaccaa gtggctgaga ggcgagccca gccacgagaa caacagacag     1380

gaggactgcg tggtgatgaa gggcaaggac ggctactggg ccgacagagg ctgcgagtgg     1440

cccctgggct acatctgcaa gatgaagagc agaagccagg gccccgagat cgtggaggtg     1500

gagaagggct gcagaaaggg ctggaagaag caccacttct actgctacat gatcggccac     1560

accctgagca ccttcgccga ggccaaccag acctgcaaca acgagaacgc ctacctgacc     1620

accatcgagg acagatacga gcaggccttc ctgaccagct tcgtgggcct gagacccgag     1680

aagtacttct ggaccggcct gagcgacatc cagaccaagg gcaccttcca gtggaccatc     1740

gaggaggagg tgagattcac ccactggaac agcgacatgc ccggcagaaa gcccggctgc     1800

gtggccatga gaaccggcat cgccggcggc ctgtgggacg tgctgaagtg cgacgagaag     1860

gccaagttcg tgtgcaagca ctgggccgag ggcgtgaccc acccccccaa gcccaccacc     1920

acccccgagc ccaagtgccc cgaggactgg ggcgccagca gcagaaccag cctgtgcttc     1980

aagctgtacg ccaagggcaa gcacgagaag aagacctggt tcgagagcag agacttctgc     2040

agagccctgg gcggcgacct ggctagc                                         2067


<210> 4
<211> 1456
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Leu Pro Leu Leu Leu Val Phe Ala Ser Val Ile Pro Gly Ala 
1               5                   10                  15      


Val Leu Leu Leu Asp Thr Arg Gln Phe Leu Ile Tyr Asn Glu Asp His 
            20                  25                  30          


Lys Arg Cys Val Asp Ala Val Ser Pro Ser Ala Val Gln Thr Ala Ala 
        35                  40                  45              


Cys Asn Gln Asp Ala Glu Ser Gln Lys Phe Arg Trp Val Ser Glu Ser 
    50                  55                  60                  


Gln Ile Met Ser Val Ala Phe Lys Leu Cys Leu Gly Val Pro Ser Lys 
65                  70                  75                  80  


Thr Asp Trp Val Ala Ile Thr Leu Tyr Ala Cys Asp Ser Lys Ser Glu 
                85                  90                  95      


Phe Gln Lys Trp Glu Cys Lys Asn Asp Thr Leu Leu Gly Ile Lys Gly 
            100                 105                 110         


Glu Asp Leu Phe Phe Asn Tyr Gly Asn Arg Gln Glu Lys Asn Ile Met 
        115                 120                 125             


Leu Tyr Lys Gly Ser Gly Leu Trp Ser Arg Trp Lys Ile Tyr Gly Thr 
    130                 135                 140                 


Thr Asp Asn Leu Cys Ser Arg Gly Tyr Glu Ala Met Tyr Thr Leu Leu 
145                 150                 155                 160 


Gly Asn Ala Asn Gly Ala Thr Cys Ala Phe Pro Phe Lys Phe Glu Asn 
                165                 170                 175     


Lys Trp Tyr Ala Asp Cys Thr Ser Ala Gly Arg Ser Asp Gly Trp Leu 
            180                 185                 190         


Trp Cys Gly Thr Thr Thr Asp Tyr Asp Thr Asp Lys Leu Phe Gly Tyr 
        195                 200                 205             


Cys Pro Leu Lys Phe Glu Gly Ser Glu Ser Leu Trp Asn Lys Asp Pro 
    210                 215                 220                 


Leu Thr Ser Val Ser Tyr Gln Ile Asn Ser Lys Ser Ala Leu Thr Trp 
225                 230                 235                 240 


His Gln Ala Arg Lys Ser Cys Gln Gln Gln Asn Ala Glu Leu Leu Ser 
                245                 250                 255     


Ile Thr Glu Ile His Glu Gln Thr Tyr Leu Thr Gly Leu Thr Ser Ser 
            260                 265                 270         


Leu Thr Ser Gly Leu Trp Ile Gly Leu Asn Ser Leu Ser Phe Asn Ser 
        275                 280                 285             


Gly Trp Gln Trp Ser Asp Arg Ser Pro Phe Arg Tyr Leu Asn Trp Leu 
    290                 295                 300                 


Pro Gly Ser Pro Ser Ala Glu Pro Gly Lys Ser Cys Val Ser Leu Asn 
305                 310                 315                 320 


Pro Gly Lys Asn Ala Lys Trp Glu Asn Leu Glu Cys Val Gln Lys Leu 
                325                 330                 335     


Gly Tyr Ile Cys Lys Lys Gly Asn Thr Thr Leu Asn Ser Phe Val Ile 
            340                 345                 350         


Pro Ser Glu Ser Asp Val Pro Thr His Cys Pro Ser Gln Trp Trp Pro 
        355                 360                 365             


Tyr Ala Gly His Cys Tyr Lys Ile His Arg Asp Glu Lys Lys Ile Gln 
    370                 375                 380                 


Arg Asp Ala Leu Thr Thr Cys Arg Lys Glu Gly Gly Asp Leu Thr Ser 
385                 390                 395                 400 


Ile His Thr Ile Glu Glu Leu Asp Phe Ile Ile Ser Gln Leu Gly Tyr 
                405                 410                 415     


Glu Pro Asn Asp Glu Leu Trp Ile Gly Leu Asn Asp Ile Lys Ile Gln 
            420                 425                 430         


Met Tyr Phe Glu Trp Ser Asp Gly Thr Pro Val Thr Phe Thr Lys Trp 
        435                 440                 445             


Leu Arg Gly Glu Pro Ser His Glu Asn Asn Arg Gln Glu Asp Cys Val 
    450                 455                 460                 


Val Met Lys Gly Lys Asp Gly Tyr Trp Ala Asp Arg Gly Cys Glu Trp 
465                 470                 475                 480 


Pro Leu Gly Tyr Ile Cys Lys Met Lys Ser Arg Ser Gln Gly Pro Glu 
                485                 490                 495     


Ile Val Glu Val Glu Lys Gly Cys Arg Lys Gly Trp Lys Lys His His 
            500                 505                 510         


Phe Tyr Cys Tyr Met Ile Gly His Thr Leu Ser Thr Phe Ala Glu Ala 
        515                 520                 525             


Asn Gln Thr Cys Asn Asn Glu Asn Ala Tyr Leu Thr Thr Ile Glu Asp 
    530                 535                 540                 


Arg Tyr Glu Gln Ala Phe Leu Thr Ser Phe Val Gly Leu Arg Pro Glu 
545                 550                 555                 560 


Lys Tyr Phe Trp Thr Gly Leu Ser Asp Ile Gln Thr Lys Gly Thr Phe 
                565                 570                 575     


Gln Trp Thr Ile Glu Glu Glu Val Arg Phe Thr His Trp Asn Ser Asp 
            580                 585                 590         


Met Pro Gly Arg Lys Pro Gly Cys Val Ala Met Arg Thr Gly Ile Ala 
        595                 600                 605             


Gly Gly Leu Trp Asp Val Leu Lys Cys Asp Glu Lys Ala Lys Phe Val 
    610                 615                 620                 


Cys Lys His Trp Ala Glu Gly Val Thr His Pro Pro Lys Pro Thr Thr 
625                 630                 635                 640 


Thr Pro Glu Pro Lys Cys Pro Glu Asp Trp Gly Ala Ser Ser Arg Thr 
                645                 650                 655     


Ser Leu Cys Phe Lys Leu Tyr Ala Lys Gly Lys His Glu Lys Lys Thr 
            660                 665                 670         


Trp Phe Glu Ser Arg Asp Phe Cys Arg Ala Leu Gly Gly Asp Leu Ala 
        675                 680                 685             


Ser Ile Asn Asn Lys Glu Glu Gln Gln Thr Ile Trp Arg Leu Ile Thr 
    690                 695                 700                 


Ala Ser Gly Ser Tyr His Lys Leu Phe Trp Leu Gly Leu Thr Tyr Gly 
705                 710                 715                 720 


Ser Pro Ser Glu Gly Phe Thr Trp Ser Asp Gly Ser Pro Val Ser Tyr 
                725                 730                 735     


Glu Asn Trp Ala Tyr Gly Glu Pro Asn Asn Tyr Gln Asn Val Glu Tyr 
            740                 745                 750         


Cys Gly Glu Leu Lys Gly Asp Pro Thr Met Ser Trp Asn Asp Ile Asn 
        755                 760                 765             


Cys Glu His Leu Asn Asn Trp Ile Cys Gln Ile Gln Lys Gly Gln Thr 
    770                 775                 780                 


Pro Lys Pro Glu Pro Thr Pro Ala Pro Gln Asp Asn Pro Pro Val Thr 
785                 790                 795                 800 


Glu Asp Gly Trp Val Ile Tyr Lys Asp Tyr Gln Tyr Tyr Phe Ser Lys 
                805                 810                 815     


Glu Lys Glu Thr Met Asp Asn Ala Arg Ala Phe Cys Lys Arg Asn Phe 
            820                 825                 830         


Gly Asp Leu Val Ser Ile Gln Ser Glu Ser Glu Lys Lys Phe Leu Trp 
        835                 840                 845             


Lys Tyr Val Asn Arg Asn Asp Ala Gln Ser Ala Tyr Phe Ile Gly Leu 
    850                 855                 860                 


Leu Ile Ser Leu Asp Lys Lys Phe Ala Trp Met Asp Gly Ser Lys Val 
865                 870                 875                 880 


Asp Tyr Val Ser Trp Ala Thr Gly Glu Pro Asn Phe Ala Asn Glu Asp 
                885                 890                 895     


Glu Asn Cys Val Thr Met Tyr Ser Asn Ser Gly Phe Trp Asn Asp Ile 
            900                 905                 910         


Asn Cys Gly Tyr Pro Asn Ala Phe Ile Cys Gln Arg His Asn Ser Ser 
        915                 920                 925             


Ile Asn Ala Thr Thr Val Met Pro Thr Met Pro Ser Val Pro Ser Gly 
    930                 935                 940                 


Cys Lys Glu Gly Trp Asn Phe Tyr Ser Asn Lys Cys Phe Lys Ile Phe 
945                 950                 955                 960 


Gly Phe Met Glu Glu Glu Arg Lys Asn Trp Gln Glu Ala Arg Lys Ala 
                965                 970                 975     


Cys Ile Gly Phe Gly Gly Asn Leu Val Ser Ile Gln Asn Glu Lys Glu 
            980                 985                 990         


Gln Ala Phe Leu Thr Tyr His Met  Lys Asp Ser Thr Phe  Ser Ala Trp 
        995                 1000                 1005             


Thr Gly  Leu Asn Asp Val Asn  Ser Glu His Thr Phe  Leu Trp Thr 
    1010                 1015                 1020             


Asp Gly  Arg Gly Val His Tyr  Thr Asn Trp Gly Lys  Gly Tyr Pro 
    1025                 1030                 1035             


Gly Gly  Arg Arg Ser Ser Leu  Ser Tyr Glu Asp Ala  Asp Cys Val 
    1040                 1045                 1050             


Val Ile  Ile Gly Gly Ala Ser  Asn Glu Ala Gly Lys  Trp Met Asp 
    1055                 1060                 1065             


Asp Thr  Cys Asp Ser Lys Arg  Gly Tyr Ile Cys Gln  Thr Arg Ser 
    1070                 1075                 1080             


Asp Pro  Ser Leu Thr Asn Pro  Pro Ala Thr Ile Gln  Thr Asp Gly 
    1085                 1090                 1095             


Phe Val  Lys Tyr Gly Lys Ser  Ser Tyr Ser Leu Met  Arg Gln Lys 
    1100                 1105                 1110             


Phe Gln  Trp His Glu Ala Glu  Thr Tyr Cys Lys Leu  His Asn Ser 
    1115                 1120                 1125             


Leu Ile  Ala Ser Ile Leu Asp  Pro Tyr Ser Asn Ala  Phe Ala Trp 
    1130                 1135                 1140             


Leu Gln  Met Glu Thr Ser Asn  Glu Arg Val Trp Ile  Ala Leu Asn 
    1145                 1150                 1155             


Ser Asn  Leu Thr Asp Asn Gln  Tyr Thr Trp Thr Asp  Lys Trp Arg 
    1160                 1165                 1170             


Val Arg  Tyr Thr Asn Trp Ala  Ala Asp Glu Pro Lys  Leu Lys Ser 
    1175                 1180                 1185             


Ala Cys  Val Tyr Leu Asp Leu  Asp Gly Tyr Trp Lys  Thr Ala His 
    1190                 1195                 1200             


Cys Asn  Glu Ser Phe Tyr Phe  Leu Cys Lys Arg Ser  Asp Glu Ile 
    1205                 1210                 1215             


Pro Ala  Thr Glu Pro Pro Gln  Leu Pro Gly Arg Cys  Pro Glu Ser 
    1220                 1225                 1230             


Asp His  Thr Ala Trp Ile Pro  Phe His Gly His Cys  Tyr Tyr Ile 
    1235                 1240                 1245             


Glu Ser  Ser Tyr Thr Arg Asn  Trp Gly Gln Ala Ser  Leu Glu Cys 
    1250                 1255                 1260             


Leu Arg  Met Gly Ser Ser Leu  Val Ser Ile Glu Ser  Ala Ala Glu 
    1265                 1270                 1275             


Ser Ser  Phe Leu Ser Tyr Arg  Val Glu Pro Leu Lys  Ser Lys Thr 
    1280                 1285                 1290             


Asn Phe  Trp Ile Gly Leu Phe  Arg Asn Val Glu Gly  Thr Trp Leu 
    1295                 1300                 1305             


Trp Ile  Asn Asn Ser Pro Val  Ser Phe Val Asn Trp  Asn Thr Gly 
    1310                 1315                 1320             


Asp Pro  Ser Gly Glu Arg Asn  Asp Cys Val Ala Leu  His Ala Ser 
    1325                 1330                 1335             


Ser Gly  Phe Trp Ser Asn Ile  His Cys Ser Ser Tyr  Lys Gly Tyr 
    1340                 1345                 1350             


Ile Cys  Lys Arg Pro Lys Ile  Ile Asp Ala Lys Pro  Thr His Glu 
    1355                 1360                 1365             


Leu Leu  Thr Thr Lys Ala Asp  Thr Arg Lys Met Asp  Pro Ser Lys 
    1370                 1375                 1380             


Pro Ser  Ser Asn Val Ala Gly  Val Val Ile Ile Val  Ile Leu Leu 
    1385                 1390                 1395             


Ile Leu  Thr Gly Ala Gly Leu  Ala Ala Tyr Phe Phe  Tyr Lys Lys 
    1400                 1405                 1410             


Arg Arg  Val His Leu Pro Gln  Glu Gly Ala Phe Glu  Asn Thr Leu 
    1415                 1420                 1425             


Tyr Phe  Asn Ser Gln Ser Ser  Pro Gly Thr Ser Asp  Met Lys Asp 
    1430                 1435                 1440             


Leu Val  Gly Asn Ile Glu Gln  Asn Glu His Ser Val  Ile 
    1445                 1450                 1455     


<210> 5
<211> 31
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
ttacgcgtcc accatgaggc tacccctgct c                                      31


<210> 6
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
ttaattaact agatgaccga gtgt                                              24


<210> 7
<211> 2067
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Consensus polynucleotide

<400> 7
atgagactgc ccctgctgct ggtgttcgcc agcgtgatcc ccggcgccgt gctgctgctg       60

gacaccagac agttcctgat ctacaacgag gaccacaaga gatgcgtgga cgccgtgagc      120

cccagcgccg tgcagaccgc cgcctgcaac caggacgccg agagccagaa gttcagatgg      180

gtgagcgaga gccagatcat gagcgtggcc ttcaagctgt gcctgggcgt gcccagcaag      240

accgactggg tggccatcac cctgtacgcc tgcgacagca agagcgagtt ccagaagtgg      300

gagtgcaaga acgacaccct gctgggcatc aagggcgagg acctgttctt caactacggc      360

aacagacagg agaagaacat catgctgtac aagggcagcg gcctgtggag cagatggaag      420

atctacggca ccaccgacaa cctgtgcagc agaggctacg aggccatgta caccctgctg      480

ggcaacgcca acggcgccac ctgcgccttc cccttcaagt tcgagaacaa gtggtacgcc      540

gactgcacca gcgccggcag aagcgacggc tggctgtggt gcggcaccac caccgactac      600

gacaccgaca agctgttcgg ctactgcccc ctgaagttcg agggcagcga gagcctgtgg      660

aacaaggacc ccctgaccag cgtgagctac cagatcaaca gcaagagcgc cctgacctgg      720

caccaggcca gaaagagctg ccagcagcag aacgccgagc tgctgagcat caccgagatc      780

cacgagcaga cctacctgac cggcctgacc agcagcctga ccagcggcct gtggatcggc      840

ctgaacagcc tgagcttcaa cagcggctgg cagtggagcg acagaagccc cttcagatac      900

ctgaactggc tgcccggcag ccccagcgcc gagcccggca agagctgcgt gagcctgaac      960

cccggcaaga acgccaagtg ggagaacctg gagtgcgtgc agaagctggg ctacatctgc     1020

aagaagggca acaccaccct gaacagcttc gtgatcccca gcgagagcga cgtgcccacc     1080

cactgcccca gccagtggtg gccctacgcc ggccactgct acaagatcca cagagacgag     1140

aagaagatcc agagagacgc cctgaccacc tgcagaaagg agggcggcga cctgaccagc     1200

atccacacca tcgaggagtt ggacttcatc atcagccagc tgggctacga gcccaacgac     1260

gagctgtgga tcggcctgaa cgacatcaag atccagatgt acttcgagtg gagcgacggc     1320

acccccgtga ccttcaccaa gtggctgaga ggcgagccca gccacgagaa caacagacag     1380

gaggactgcg tggtgatgaa gggcaaggac ggctactggg ccgacagagg ctgcgagtgg     1440

cccctgggct acatctgcaa gatgaagagc agaagccagg gccccgagat cgtggaggtg     1500

gagaagggct gcagaaaggg ctggaagaag caccacttct actgctacat gatcggccac     1560

accctgagca ccttcgccga ggccaaccag acctgcaaca acgagaacgc ctacctgacc     1620

accatcgagg acagatacga gcaggccttc ctgaccagct tcgtgggcct gagacccgag     1680

aagtacttct ggaccggcct gagcgacatc cagaccaagg gcaccttcca gtggaccatc     1740

gaggaggagg tgagattcac ccactggaac agcgacatgc ccggcagaaa gcccggctgc     1800

gtggccatga gaaccggcat cgccggcggc ctgtgggacg tgctgaagtg cgacgagaag     1860

gccaagttcg tgtgcaagca ctgggccgag ggcgtgaccc acccccccaa gcccaccacc     1920

acccccgagc ccaagtgccc cgaggactgg ggcgccagca gcagaaccag cctgtgcttc     1980

aagctgtacg ccaagggcaa gcacgagaag aagacctggt tcgagagcag agacttctgc     2040

agagccctgg gcggcgacct ggctagc                                         2067


<210> 8
<211> 2067
<212> DNA
<213> Homo sapiens

<400> 8
atgaggctac ccctgctcct ggtttttgcc tctgtcattc cgggtgctgt tctcctactg       60

gacaccaggc aatttttaat ctataatgaa gatcacaagc gctgcgtgga tgcagtgagt      120

cccagtgccg tccaaaccgc agcttgcaac caggatgccg aatcacagaa attccgatgg      180

gtgtccgaat ctcagattat gagtgttgca tttaaattat gcctgggagt gccatcaaaa      240

acagactggg ttgctatcac tctctatgcc tgtgactcaa aaagtgaatt tcagaaatgg      300

gagtgcaaaa atgacacact tttggggatc aaaggagaag atttattttt taactacggc      360

aacagacaag aaaagaatat tatgctctac aagggatcgg gtttatggag caggtggaag      420

atctatggaa ccacagacaa tctgtgctcc agaggttatg aagccatgta tacgctacta      480

ggcaatgcca atggagcaac ctgtgcattc ccgttcaagt ttgaaaacaa gtggtacgca      540

gattgcacga gtgctgggcg gtcggatgga tggctctggt gcggaaccac tactgactat      600

gacacagaca agctatttgg atattgtcca ttgaaatttg agggcagtga aagcttatgg      660

aataaagacc cgctgaccag cgtttcctac cagataaact ccaaatccgc tttaacgtgg      720

caccaagcga ggaaaagctg ccaacaacag aacgctgagc tcctgagcat cacagagata      780

catgagcaaa catacctgac aggattaacc agttccttga cctcaggact ctggattgga      840

cttaacagtc tgagcttcaa cagcggttgg cagtggagtg accgcagtcc tttccgatat      900

ttgaactggt taccaggaag tccatcagct gaacctggaa aaagctgtgt gtcactaaat      960

cctggaaaaa atgctaaatg ggaaaatctg gaatgtgttc agaaactggg ctatatttgc     1020

aaaaagggca acaccacttt aaattctttt gttattccct cagaaagtga tgtgcctact     1080

cactgtccta gtcagtggtg gccgtatgcc ggtcactgtt acaagattca cagagatgag     1140

aaaaaaatcc agagggatgc tctgaccacc tgcaggaagg aaggcggtga cctcacaagt     1200

atccacacca tcgaggaatt ggactttatt atctcccagc taggatatga gccaaatgac     1260

gaattgtgga tcggcttaaa tgacattaag attcaaatgt actttgagtg gagtgatggg     1320

acccctgtaa cgtttaccaa atggcttcgt ggagaaccaa gccatgaaaa caacagacag     1380

gaggattgtg tggtgatgaa aggcaaggat gggtactggg cagatcgggg ctgtgagtgg     1440

cctcttggct acatctgcaa gatgaaatca cgaagccaag gtccagaaat agtggaagtc     1500

gaaaaaggct gcaggaaagg ctggaaaaaa catcactttt actgctatat gattggacat     1560

acgctttcaa catttgcaga agcaaaccaa acctgtaata atgagaatgc ttatttaaca     1620

actattgaag acagatatga acaagccttc ctgactagtt tcgttggctt aaggcctgaa     1680

aaatatttct ggacaggact ttcagatata caaaccaaag ggacttttca gtggaccatc     1740

gaggaagagg ttcggttcac ccactggaat tcagatatgc cagggcgaaa gccagggtgt     1800

gttgccatga gaaccgggat tgcagggggc ttatgggatg ttttgaaatg tgatgaaaag     1860

gcaaaatttg tgtgcaagca ctgggcagaa ggagtaaccc acccaccgaa gcccacgacg     1920

actcccgaac ccaaatgtcc ggaggattgg ggcgccagca gtagaacaag cttgtgtttc     1980

aagctgtatg caaaaggaaa acatgagaag aaaacgtggt ttgaatctcg agatttttgt     2040

cgagctctgg gtggagactt agctagc                                         2067


