                         SEQUENCE LISTING

<110>  AMGEN INC.
       Quon, Kim Coign
       Cutler, Gene
       Kordich, Jennifer Joy
 
<120>  FUSION PROTEINS IN CANCER

<130>  A-1587-WO-PCT

<140>  -to be assigned-
<141>  2011-06-28

<150>  US 61/360,381
<151>  2010-06-30

<150>  US 61/501,080
<151>  2011-06-24

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Asn Ser Glu Ser Pro Ser Val Thr Val Leu Leu Glu Leu Leu Val 
1               5                   10                  15      


Gly Ile Tyr 
            


<210>  2
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Arg Gly Gly Arg Gly Ala Gln Glu Val Leu Leu Glu Leu Leu Val 
1               5                   10                  15      


Gly Ile Tyr 
            


<210>  3
<211>  3834
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (290)..(3247)

<400>  3
cttgcctgtc tgcgtctaaa gcccctgccc agagtccgcc ttctcaggtc cagtactccc       60

agttcacctg ccctcgggag ccctccttcc ttcggaaaac tcccggctct gactcctcct      120

cagcccctcc ccccgccctg ctcaccttta attgagatgc taatgagatt cctgtcgctt      180

ccatccctgg ccggccagcg ggcgggctcc ccagccaggc cgctgcacct gtcaggggaa      240

caagctggag gagcaggacc ctagacctct gcagcccata ccaggtctc atg gag ggg      298
                                                      Met Glu Gly         
                                                      1                   

aac aag ctg gag gag cag gac tct agc cct cca cag tcc act cca ggg        346
Asn Lys Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser Thr Pro Gly           
    5                   10                  15                            

ctc atg aag ggg aac aag cgt gag gag cag ggg ctg ggc ccc gaa cct        394
Leu Met Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly Pro Glu Pro           
20                  25                  30                  35            

gcg gcg ccc cag cag ccc acg gcg gag gag gag gcc ctg atc gag ttc        442
Ala Ala Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu Ile Glu Phe           
                40                  45                  50                

cac cgc tcc tac cga gag ctc ttc gag ttc ttc tgc aac aac acc acc        490
His Arg Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn Asn Thr Thr           
            55                  60                  65                    

atc cac ggc gcc atc cgc ctg gtg tgc tcc cag cac aac cgc atg aag        538
Ile His Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn Arg Met Lys           
        70                  75                  80                        

acg gcc ttc tgg gca gtg ctg tgg ctc tgc acc ttt ggc atg atg tac        586
Thr Ala Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly Met Met Tyr           
    85                  90                  95                            

tgg caa ttc ggc ctg ctt ttc gga gag tac ttc agc tac ccc gtc agc        634
Trp Gln Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr Pro Val Ser           
100                 105                 110                 115           

ctc aac atc aac ctc aac tcg gac aag ctc gtc ttc ccc gca gtg acc        682
Leu Asn Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro Ala Val Thr           
                120                 125                 130               

atc tgc acc ctc aat ccc tac agg tac ccg gaa att aaa gag gag ctg        730
Ile Cys Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys Glu Glu Leu           
            135                 140                 145                   

gag gag ctg gac cgc atc aca gag cag acg ctc ttt gac ctg tac aaa        778
Glu Glu Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp Leu Tyr Lys           
        150                 155                 160                       

tac agc tcc ttc acc act ctc gtg gcc ggc tcc cgc agc cgt cgc gac        826
Tyr Ser Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser Arg Arg Asp           
    165                 170                 175                           

ctg cgg ggg act ctg ccg cac ccc ttg cag cgc ctg agg gtc ccg ccc        874
Leu Arg Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg Val Pro Pro           
180                 185                 190                 195           

ccg cct cac ggg gcc cgt cga gcc cgt agc gtg gcc tcc agc ttg cgg        922
Pro Pro His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser Ser Leu Arg           
                200                 205                 210               

gac aac aac ccc cag gtg gac tgg aag gac tgg aag atc ggc ttc cag        970
Asp Asn Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile Gly Phe Gln           
            215                 220                 225                   

ctg tgc aac cag aac aaa tcg gac tgc ttc tac cag aca tac tca tca       1018
Leu Cys Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr Tyr Ser Ser           
        230                 235                 240                       

ggg gtg gat gcg gtg agg gag tgg tac cgc ttc cac tac atc aac atc       1066
Gly Val Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr Ile Asn Ile           
    245                 250                 255                           

ctg tcg agg ctg cca gag act ctg cca tcc ctg gag gag gac acg ctg       1114
Leu Ser Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu Asp Thr Leu           
260                 265                 270                 275           

ggc aac ttc atc ttc gcc tgc cgc ttc aac cag gtc tcc tgc aac cag       1162
Gly Asn Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser Cys Asn Gln           
                280                 285                 290               

gcg aat tac tct cac ttc cac cac ccg atg tat gga aac tgc tat act       1210
Ala Asn Tyr Ser His Phe His His Pro Met Tyr Gly Asn Cys Tyr Thr           
            295                 300                 305                   

ttc aat gac aag aac aac tcc aac ctc tgg atg tct tcc atg cct gga       1258
Phe Asn Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser Met Pro Gly           
        310                 315                 320                       

atc aac aac ggt ctg tcc ctg atg ctg cgc gca gag cag aat gac ttc       1306
Ile Asn Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln Asn Asp Phe           
    325                 330                 335                           

att ccc ctg ctg tcc aca gtg act ggg gcc cgg gta atg gtg cac ggg       1354
Ile Pro Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met Val His Gly           
340                 345                 350                 355           

cag gat gaa cct gcc ttt atg gat gat ggt ggc ttt aac ttg cgg cct       1402
Gln Asp Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn Leu Arg Pro           
                360                 365                 370               

ggc gtg gag acc tcc atc agc atg agg aag gaa acc ctg gac aga ctt       1450
Gly Val Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu Asp Arg Leu           
            375                 380                 385                   

ggg ggc gat tat ggc gac tgc acc aag aat ggc agt gat gtt cct gtt       1498
Gly Gly Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp Val Pro Val           
        390                 395                 400                       

gag aac ctt tac cct tca aag tac aca cag cag gtg tgt att cac tcc       1546
Glu Asn Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys Ile His Ser           
    405                 410                 415                           

tgc ttc cag gag agc atg atc aag gag tgt ggc tgt gcc tac atc ttc       1594
Cys Phe Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala Tyr Ile Phe           
420                 425                 430                 435           

tat ccg cgg ccc cag aac gtg gag tac tgt gac tac aga aag cac agt       1642
Tyr Pro Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg Lys His Ser           
                440                 445                 450               

tcc tgg ggg tac tgc tac tat aag ctc cag gtt gac ttc tcc tca gac       1690
Ser Trp Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe Ser Ser Asp           
            455                 460                 465                   

cac ctg ggc tgt ttc acc aag tgc cgg aag cca tgc agc gtg acc agc       1738
His Leu Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser Val Thr Ser           
        470                 475                 480                       

tac cag ctc tct gct ggt tac tca cga tgg ccc tcg gtg aca tcc cag       1786
Tyr Gln Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val Thr Ser Gln           
    485                 490                 495                           

gaa tgg gtc ttc cag atg cta tcg cga cag aac aat tac acc gtc aac       1834
Glu Trp Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr Thr Val Asn           
500                 505                 510                 515           

aac aag aga aat gga gtg gcc aaa gtc aac atc ttc ttc aag gag ctg       1882
Asn Lys Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe Lys Glu Leu           
                520                 525                 530               

aac tac aaa acc aat tct gag tct ccc tct gtc acg gtg ctc ctg gag       1930
Asn Tyr Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Val Leu Leu Glu           
            535                 540                 545                   

ctg ttg gtg gga ata tac ccc tca ggg gtt att gga ctg gtc cct cac       1978
Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His           
        550                 555                 560                       

cta ggg gac agg gag aag aga gat agt gtg tgt ccc caa gga aaa tat       2026
Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr           
    565                 570                 575                           

atc cac cct caa aat aat tcg att tgc tgt acc aag tgc cac aaa gga       2074
Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly           
580                 585                 590                 595           

acc tac ttg tac aat gac tgt cca ggc ccg ggg cag gat acg gac tgc       2122
Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys           
                600                 605                 610               

agg gag tgt gag agc ggc tcc ttc acc gct tca gaa aac cac ctc aga       2170
Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg           
            615                 620                 625                   

cac tgc ctc agc tgc tcc aaa tgc cga aag gaa atg ggt cag gtg gag       2218
His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu           
        630                 635                 640                       

atc tct tct tgc aca gtg gac cgg gac acc gtg tgt ggc tgc agg aag       2266
Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys           
    645                 650                 655                           

aac cag tac cgg cat tat tgg agt gaa aac ctt ttc cag tgc ttc aat       2314
Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn           
660                 665                 670                 675           

tgc agc ctc tgc ctc aat ggg acc gtg cac ctc tcc tgc cag gag aaa       2362
Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys           
                680                 685                 690               

cag aac acc gtg tgc acc tgc cat gca ggt ttc ttt cta aga gaa aac       2410
Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn           
            695                 700                 705                   

gag tgt gtc tcc tgt agt aac tgt aag aaa agc ctg gag tgc acg aag       2458
Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys           
        710                 715                 720                       

ttg tgc cta ccc cag att gag aat gtt aag ggc act gag gac tca ggc       2506
Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly           
    725                 730                 735                           

acc aca gtg ctg ttg ccc ctg gtc att ttc ttt ggt ctt tgc ctt tta       2554
Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu           
740                 745                 750                 755           

tcc ctc ctc ttc att ggt tta atg tat cgc tac caa cgg tgg aag tcc       2602
Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys Ser           
                760                 765                 770               

aag ctc tac tcc att gtt tgt ggg aaa tcg aca cct gaa aaa gag ggg       2650
Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu Gly           
            775                 780                 785                   

gag ctt gaa gga act act act aag ccc ctg gcc cca aac cca agc ttc       2698
Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser Phe           
        790                 795                 800                       

agt ccc act cca ggc ttc acc ccc acc ctg ggc ttc agt ccc gtg ccc       2746
Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val Pro           
    805                 810                 815                           

agt tcc acc ttc acc tcc agc tcc acc tat acc ccc ggt gac tgt ccc       2794
Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys Pro           
820                 825                 830                 835           

aac ttt gcg gct ccc cgc aga gag gtg gca cca ccc tat cag ggg gct       2842
Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly Ala           
                840                 845                 850               

gac ccc atc ctt gcg aca gcc ctc gcc tcc gac ccc atc ccc aac ccc       2890
Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn Pro           
            855                 860                 865                   

ctt cag aag tgg gag gac agc gcc cac aag cca cag agc cta gac act       2938
Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp Thr           
        870                 875                 880                       

gat gac ccc gcg acg ctg tac gcc gtg gtg gag aac gtg ccc ccg ttg       2986
Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro Leu           
    885                 890                 895                           

cgc tgg aag gaa ttc gtg cgg cgc cta ggg ctg agc gac cac gag atc       3034
Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu Ile           
900                 905                 910                 915           

gat cgg ctg gag ctg cag aac ggg cgc tgc ctg cgc gag gcg caa tac       3082
Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln Tyr           
                920                 925                 930               

agc atg ctg gcg acc tgg agg cgg cgc acg ccg cgg cgc gag gcc acg       3130
Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala Thr           
            935                 940                 945                   

ctg gag ctg ctg gga cgc gtg ctc cgc gac atg gac ctg ctg ggc tgc       3178
Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly Cys           
        950                 955                 960                       

ctg gag gac atc gag gag gcg ctt tgc ggc ccc gcc gcc ctc ccg ccc       3226
Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro Pro           
    965                 970                 975                           

gcg ccc agt ctt ctc aga tga ggctgcgccc ctgcgggcag ctctaaggac          3277
Ala Pro Ser Leu Leu Arg                                                   
980                 985                                                   

cgtcctgcga gatcgccttc caaccccact tttttctgga aaggaggggt cctgcagggg     3337

caagcaggag ctagcagccg cctacttggt gctaacccct cgatgtacat agcttttctc     3397

agctgcctgc gcgccgccga cagtcagcgc tgtgcgcgcg gagagaggtg cgccgtgggc     3457

tcaagagcct gagtgggtgg tttgcgagga tgagggacgc tatgcctcat gcccgttttg     3517

ggtgtcctca ccagcaaggc tgctcggggg cccctggttc gtccctgagc ctttttcaca     3577

gtgcataagc agtttttttt gtttttgttt tgttttgttt tgtttttaaa tcaatcatgt     3637

tacactaata gaaacttggc actcctgtgc cctctgcctg gacaagcaca tagcaagctg     3697

aactgtccta aggcaggggc gagcacggaa caatggggcc ttcagctgga gctgtggact     3757

tttgtacata cactaaaatt ctgaagttaa agctctgctc ttggaaaaaa aaaaaaaaaa     3817

aaaaaaaaaa aaaaaaa                                                    3834


<210>  4
<211>  985
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Gly Asn Lys Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser 
1               5                   10                  15      


Thr Pro Gly Leu Met Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly 
            20                  25                  30          


Pro Glu Pro Ala Ala Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu 
        35                  40                  45              


Ile Glu Phe His Arg Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn 
    50                  55                  60                  


Asn Thr Thr Ile His Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn 
65                  70                  75                  80  


Arg Met Lys Thr Ala Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly 
                85                  90                  95      


Met Met Tyr Trp Gln Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr 
            100                 105                 110         


Pro Val Ser Leu Asn Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro 
        115                 120                 125             


Ala Val Thr Ile Cys Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys 
    130                 135                 140                 


Glu Glu Leu Glu Glu Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp 
145                 150                 155                 160 


Leu Tyr Lys Tyr Ser Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser 
                165                 170                 175     


Arg Arg Asp Leu Arg Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg 
            180                 185                 190         


Val Pro Pro Pro Pro His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser 
        195                 200                 205             


Ser Leu Arg Asp Asn Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile 
    210                 215                 220                 


Gly Phe Gln Leu Cys Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr 
225                 230                 235                 240 


Tyr Ser Ser Gly Val Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr 
                245                 250                 255     


Ile Asn Ile Leu Ser Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu 
            260                 265                 270         


Asp Thr Leu Gly Asn Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser 
        275                 280                 285             


Cys Asn Gln Ala Asn Tyr Ser His Phe His His Pro Met Tyr Gly Asn 
    290                 295                 300                 


Cys Tyr Thr Phe Asn Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser 
305                 310                 315                 320 


Met Pro Gly Ile Asn Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln 
                325                 330                 335     


Asn Asp Phe Ile Pro Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met 
            340                 345                 350         


Val His Gly Gln Asp Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn 
        355                 360                 365             


Leu Arg Pro Gly Val Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu 
    370                 375                 380                 


Asp Arg Leu Gly Gly Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp 
385                 390                 395                 400 


Val Pro Val Glu Asn Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys 
                405                 410                 415     


Ile His Ser Cys Phe Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala 
            420                 425                 430         


Tyr Ile Phe Tyr Pro Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg 
        435                 440                 445             


Lys His Ser Ser Trp Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe 
    450                 455                 460                 


Ser Ser Asp His Leu Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser 
465                 470                 475                 480 


Val Thr Ser Tyr Gln Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val 
                485                 490                 495     


Thr Ser Gln Glu Trp Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr 
            500                 505                 510         


Thr Val Asn Asn Lys Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe 
        515                 520                 525             


Lys Glu Leu Asn Tyr Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Val 
    530                 535                 540                 


Leu Leu Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu 
545                 550                 555                 560 


Val Pro His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln 
                565                 570                 575     


Gly Lys Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys 
            580                 585                 590         


His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp 
        595                 600                 605             


Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn 
    610                 615                 620                 


His Leu Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly 
625                 630                 635                 640 


Gln Val Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly 
                645                 650                 655     


Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln 
            660                 665                 670         


Cys Phe Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys 
        675                 680                 685             


Gln Glu Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu 
    690                 695                 700                 


Arg Glu Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu 
705                 710                 715                 720 


Cys Thr Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu 
                725                 730                 735     


Asp Ser Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu 
            740                 745                 750         


Cys Leu Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg 
        755                 760                 765             


Trp Lys Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu 
    770                 775                 780                 


Lys Glu Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn 
785                 790                 795                 800 


Pro Ser Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser 
                805                 810                 815     


Pro Val Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly 
            820                 825                 830         


Asp Cys Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr 
        835                 840                 845             


Gln Gly Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile 
    850                 855                 860                 


Pro Asn Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser 
865                 870                 875                 880 


Leu Asp Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val 
                885                 890                 895     


Pro Pro Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp 
            900                 905                 910         


His Glu Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu 
        915                 920                 925             


Ala Gln Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg 
    930                 935                 940                 


Glu Ala Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu 
945                 950                 955                 960 


Leu Gly Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala 
                965                 970                 975     


Leu Pro Pro Ala Pro Ser Leu Leu Arg 
            980                 985 


<210>  5
<211>  4017
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (290)..(3430)

<400>  5
cttgcctgtc tgcgtctaaa gcccctgccc agagtccgcc ttctcaggtc cagtactccc       60

agttcacctg ccctcgggag ccctccttcc ttcggaaaac tcccggctct gactcctcct      120

cagcccctcc ccccgccctg ctcaccttta attgagatgc taatgagatt cctgtcgctt      180

ccatccctgg ccggccagcg ggcgggctcc ccagccaggc cgctgcacct gtcaggggaa      240

caagctggag gagcaggacc ctagacctct gcagcccata ccaggtctc atg gag ggg      298
                                                      Met Glu Gly         
                                                      1                   

aac aag ctg gag gag cag gac tct agc cct cca cag tcc act cca ggg        346
Asn Lys Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser Thr Pro Gly           
    5                   10                  15                            

ctc atg aag ggg aac aag cgt gag gag cag ggg ctg ggc ccc gaa cct        394
Leu Met Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly Pro Glu Pro           
20                  25                  30                  35            

gcg gcg ccc cag cag ccc acg gcg gag gag gag gcc ctg atc gag ttc        442
Ala Ala Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu Ile Glu Phe           
                40                  45                  50                

cac cgc tcc tac cga gag ctc ttc gag ttc ttc tgc aac aac acc acc        490
His Arg Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn Asn Thr Thr           
            55                  60                  65                    

atc cac ggc gcc atc cgc ctg gtg tgc tcc cag cac aac cgc atg aag        538
Ile His Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn Arg Met Lys           
        70                  75                  80                        

acg gcc ttc tgg gca gtg ctg tgg ctc tgc acc ttt ggc atg atg tac        586
Thr Ala Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly Met Met Tyr           
    85                  90                  95                            

tgg caa ttc ggc ctg ctt ttc gga gag tac ttc agc tac ccc gtc agc        634
Trp Gln Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr Pro Val Ser           
100                 105                 110                 115           

ctc aac atc aac ctc aac tcg gac aag ctc gtc ttc ccc gca gtg acc        682
Leu Asn Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro Ala Val Thr           
                120                 125                 130               

atc tgc acc ctc aat ccc tac agg tac ccg gaa att aaa gag gag ctg        730
Ile Cys Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys Glu Glu Leu           
            135                 140                 145                   

gag gag ctg gac cgc atc aca gag cag acg ctc ttt gac ctg tac aaa        778
Glu Glu Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp Leu Tyr Lys           
        150                 155                 160                       

tac agc tcc ttc acc act ctc gtg gcc ggc tcc cgc agc cgt cgc gac        826
Tyr Ser Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser Arg Arg Asp           
    165                 170                 175                           

ctg cgg ggg act ctg ccg cac ccc ttg cag cgc ctg agg gtc ccg ccc        874
Leu Arg Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg Val Pro Pro           
180                 185                 190                 195           

ccg cct cac ggg gcc cgt cga gcc cgt agc gtg gcc tcc agc ttg cgg        922
Pro Pro His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser Ser Leu Arg           
                200                 205                 210               

gac aac aac ccc cag gtg gac tgg aag gac tgg aag atc ggc ttc cag        970
Asp Asn Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile Gly Phe Gln           
            215                 220                 225                   

ctg tgc aac cag aac aaa tcg gac tgc ttc tac cag aca tac tca tca       1018
Leu Cys Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr Tyr Ser Ser           
        230                 235                 240                       

ggg gtg gat gcg gtg agg gag tgg tac cgc ttc cac tac atc aac atc       1066
Gly Val Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr Ile Asn Ile           
    245                 250                 255                           

ctg tcg agg ctg cca gag act ctg cca tcc ctg gag gag gac acg ctg       1114
Leu Ser Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu Asp Thr Leu           
260                 265                 270                 275           

ggc aac ttc atc ttc gcc tgc cgc ttc aac cag gtc tcc tgc aac cag       1162
Gly Asn Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser Cys Asn Gln           
                280                 285                 290               

gcg aat tac tct cac ttc cac cac ccg atg tat gga aac tgc tat act       1210
Ala Asn Tyr Ser His Phe His His Pro Met Tyr Gly Asn Cys Tyr Thr           
            295                 300                 305                   

ttc aat gac aag aac aac tcc aac ctc tgg atg tct tcc atg cct gga       1258
Phe Asn Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser Met Pro Gly           
        310                 315                 320                       

atc aac aac ggt ctg tcc ctg atg ctg cgc gca gag cag aat gac ttc       1306
Ile Asn Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln Asn Asp Phe           
    325                 330                 335                           

att ccc ctg ctg tcc aca gtg act ggg gcc cgg gta atg gtg cac ggg       1354
Ile Pro Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met Val His Gly           
340                 345                 350                 355           

cag gat gaa cct gcc ttt atg gat gat ggt ggc ttt aac ttg cgg cct       1402
Gln Asp Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn Leu Arg Pro           
                360                 365                 370               

ggc gtg gag acc tcc atc agc atg agg aag gaa acc ctg gac aga ctt       1450
Gly Val Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu Asp Arg Leu           
            375                 380                 385                   

ggg ggc gat tat ggc gac tgc acc aag aat ggc agt gat gtt cct gtt       1498
Gly Gly Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp Val Pro Val           
        390                 395                 400                       

gag aac ctt tac cct tca aag tac aca cag cag gtg tgt att cac tcc       1546
Glu Asn Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys Ile His Ser           
    405                 410                 415                           

tgc ttc cag gag agc atg atc aag gag tgt ggc tgt gcc tac atc ttc       1594
Cys Phe Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala Tyr Ile Phe           
420                 425                 430                 435           

tat ccg cgg ccc cag aac gtg gag tac tgt gac tac aga aag cac agt       1642
Tyr Pro Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg Lys His Ser           
                440                 445                 450               

tcc tgg ggg tac tgc tac tat aag ctc cag gtt gac ttc tcc tca gac       1690
Ser Trp Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe Ser Ser Asp           
            455                 460                 465                   

cac ctg ggc tgt ttc acc aag tgc cgg aag cca tgc agc gtg acc agc       1738
His Leu Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser Val Thr Ser           
        470                 475                 480                       

tac cag ctc tct gct ggt tac tca cga tgg ccc tcg gtg aca tcc cag       1786
Tyr Gln Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val Thr Ser Gln           
    485                 490                 495                           

gaa tgg gtc ttc cag atg cta tcg cga cag aac aat tac acc gtc aac       1834
Glu Trp Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr Thr Val Asn           
500                 505                 510                 515           

aac aag aga aat gga gtg gcc aaa gtc aac atc ttc ttc aag gag ctg       1882
Asn Lys Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe Lys Glu Leu           
                520                 525                 530               

aac tac aaa acc aat tct gag tct ccc tct gtc acg atg gtc acc ctc       1930
Asn Tyr Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Met Val Thr Leu           
            535                 540                 545                   

ctg tcc aac ctg ggc agc cag tgg agc ctg tgg ttc ggc tcc tcg gtg       1978
Leu Ser Asn Leu Gly Ser Gln Trp Ser Leu Trp Phe Gly Ser Ser Val           
        550                 555                 560                       

ttg tct gtg gtg gag atg gct gag ctc gtc ttt gac ctg ctg gtc atc       2026
Leu Ser Val Val Glu Met Ala Glu Leu Val Phe Asp Leu Leu Val Ile           
    565                 570                 575                           

atg ttc ctc atg ctg ctc cga agg ttc cga agc cga tac tgg tct cca       2074
Met Phe Leu Met Leu Leu Arg Arg Phe Arg Ser Arg Tyr Trp Ser Pro           
580                 585                 590                 595           

ggc cga ggg ggc agg ggt gct cag gag gtg ctc ctg gag ctg ttg gtg       2122
Gly Arg Gly Gly Arg Gly Ala Gln Glu Val Leu Leu Glu Leu Leu Val           
                600                 605                 610               

gga ata tac ccc tca ggg gtt att gga ctg gtc cct cac cta ggg gac       2170
Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His Leu Gly Asp           
            615                 620                 625                   

agg gag aag aga gat agt gtg tgt ccc caa gga aaa tat atc cac cct       2218
Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr Ile His Pro           
        630                 635                 640                       

caa aat aat tcg att tgc tgt acc aag tgc cac aaa gga acc tac ttg       2266
Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly Thr Tyr Leu           
    645                 650                 655                           

tac aat gac tgt cca ggc ccg ggg cag gat acg gac tgc agg gag tgt       2314
Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys Arg Glu Cys           
660                 665                 670                 675           

gag agc ggc tcc ttc acc gct tca gaa aac cac ctc aga cac tgc ctc       2362
Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg His Cys Leu           
                680                 685                 690               

agc tgc tcc aaa tgc cga aag gaa atg ggt cag gtg gag atc tct tct       2410
Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu Ile Ser Ser           
            695                 700                 705                   

tgc aca gtg gac cgg gac acc gtg tgt ggc tgc agg aag aac cag tac       2458
Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys Asn Gln Tyr           
        710                 715                 720                       

cgg cat tat tgg agt gaa aac ctt ttc cag tgc ttc aat tgc agc ctc       2506
Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn Cys Ser Leu           
    725                 730                 735                           

tgc ctc aat ggg acc gtg cac ctc tcc tgc cag gag aaa cag aac acc       2554
Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys Gln Asn Thr           
740                 745                 750                 755           

gtg tgc acc tgc cat gca ggt ttc ttt cta aga gaa aac gag tgt gtc       2602
Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn Glu Cys Val           
                760                 765                 770               

tcc tgt agt aac tgt aag aaa agc ctg gag tgc acg aag ttg tgc cta       2650
Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys Leu Cys Leu           
            775                 780                 785                   

ccc cag att gag aat gtt aag ggc act gag gac tca ggc acc aca gtg       2698
Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly Thr Thr Val           
        790                 795                 800                       

ctg ttg ccc ctg gtc att ttc ttt ggt ctt tgc ctt tta tcc ctc ctc       2746
Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu Ser Leu Leu           
    805                 810                 815                           

ttc att ggt tta atg tat cgc tac caa cgg tgg aag tcc aag ctc tac       2794
Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys Ser Lys Leu Tyr           
820                 825                 830                 835           

tcc att gtt tgt ggg aaa tcg aca cct gaa aaa gag ggg gag ctt gaa       2842
Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu Gly Glu Leu Glu           
                840                 845                 850               

gga act act act aag ccc ctg gcc cca aac cca agc ttc agt ccc act       2890
Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser Phe Ser Pro Thr           
            855                 860                 865                   

cca ggc ttc acc ccc acc ctg ggc ttc agt ccc gtg ccc agt tcc acc       2938
Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val Pro Ser Ser Thr           
        870                 875                 880                       

ttc acc tcc agc tcc acc tat acc ccc ggt gac tgt ccc aac ttt gcg       2986
Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys Pro Asn Phe Ala           
    885                 890                 895                           

gct ccc cgc aga gag gtg gca cca ccc tat cag ggg gct gac ccc atc       3034
Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly Ala Asp Pro Ile           
900                 905                 910                 915           

ctt gcg aca gcc ctc gcc tcc gac ccc atc ccc aac ccc ctt cag aag       3082
Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn Pro Leu Gln Lys           
                920                 925                 930               

tgg gag gac agc gcc cac aag cca cag agc cta gac act gat gac ccc       3130
Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp Thr Asp Asp Pro           
            935                 940                 945                   

gcg acg ctg tac gcc gtg gtg gag aac gtg ccc ccg ttg cgc tgg aag       3178
Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro Leu Arg Trp Lys           
        950                 955                 960                       

gaa ttc gtg cgg cgc cta ggg ctg agc gac cac gag atc gat cgg ctg       3226
Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu Ile Asp Arg Leu           
    965                 970                 975                           

gag ctg cag aac ggg cgc tgc ctg cgc gag gcg caa tac agc atg ctg       3274
Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln Tyr Ser Met Leu           
980                 985                 990                 995           

gcg acc tgg agg cgg  cgc acg ccg cgg cgc  gag gcc acg ctg gag         3319
Ala Thr Trp Arg Arg  Arg Thr Pro Arg Arg  Glu Ala Thr Leu Glu             
                1000                 1005                 1010            

ctg ctg gga cgc gtg  ctc cgc gac atg gac  ctg ctg ggc tgc ctg         3364
Leu Leu Gly Arg Val  Leu Arg Asp Met Asp  Leu Leu Gly Cys Leu             
                1015                 1020                 1025            

gag gac atc gag gag  gcg ctt tgc ggc ccc  gcc gcc ctc ccg ccc         3409
Glu Asp Ile Glu Glu  Ala Leu Cys Gly Pro  Ala Ala Leu Pro Pro             
                1030                 1035                 1040            

gcg ccc agt ctt ctc  aga tga ggctgcgccc ctgcgggcag ctctaaggac         3460
Ala Pro Ser Leu Leu  Arg                                                  
                1045                                                      

cgtcctgcga gatcgccttc caaccccact tttttctgga aaggaggggt cctgcagggg     3520

caagcaggag ctagcagccg cctacttggt gctaacccct cgatgtacat agcttttctc     3580

agctgcctgc gcgccgccga cagtcagcgc tgtgcgcgcg gagagaggtg cgccgtgggc     3640

tcaagagcct gagtgggtgg tttgcgagga tgagggacgc tatgcctcat gcccgttttg     3700

ggtgtcctca ccagcaaggc tgctcggggg cccctggttc gtccctgagc ctttttcaca     3760

gtgcataagc agtttttttt gtttttgttt tgttttgttt tgtttttaaa tcaatcatgt     3820

tacactaata gaaacttggc actcctgtgc cctctgcctg gacaagcaca tagcaagctg     3880

aactgtccta aggcaggggc gagcacggaa caatggggcc ttcagctgga gctgtggact     3940

tttgtacata cactaaaatt ctgaagttaa agctctgctc ttggaaaaaa aaaaaaaaaa     4000

aaaaaaaaaa aaaaaaa                                                    4017


<210>  6
<211>  1046
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Gly Asn Lys Leu Glu Glu Gln Asp Ser Ser Pro Pro Gln Ser 
1               5                   10                  15      


Thr Pro Gly Leu Met Lys Gly Asn Lys Arg Glu Glu Gln Gly Leu Gly 
            20                  25                  30          


Pro Glu Pro Ala Ala Pro Gln Gln Pro Thr Ala Glu Glu Glu Ala Leu 
        35                  40                  45              


Ile Glu Phe His Arg Ser Tyr Arg Glu Leu Phe Glu Phe Phe Cys Asn 
    50                  55                  60                  


Asn Thr Thr Ile His Gly Ala Ile Arg Leu Val Cys Ser Gln His Asn 
65                  70                  75                  80  


Arg Met Lys Thr Ala Phe Trp Ala Val Leu Trp Leu Cys Thr Phe Gly 
                85                  90                  95      


Met Met Tyr Trp Gln Phe Gly Leu Leu Phe Gly Glu Tyr Phe Ser Tyr 
            100                 105                 110         


Pro Val Ser Leu Asn Ile Asn Leu Asn Ser Asp Lys Leu Val Phe Pro 
        115                 120                 125             


Ala Val Thr Ile Cys Thr Leu Asn Pro Tyr Arg Tyr Pro Glu Ile Lys 
    130                 135                 140                 


Glu Glu Leu Glu Glu Leu Asp Arg Ile Thr Glu Gln Thr Leu Phe Asp 
145                 150                 155                 160 


Leu Tyr Lys Tyr Ser Ser Phe Thr Thr Leu Val Ala Gly Ser Arg Ser 
                165                 170                 175     


Arg Arg Asp Leu Arg Gly Thr Leu Pro His Pro Leu Gln Arg Leu Arg 
            180                 185                 190         


Val Pro Pro Pro Pro His Gly Ala Arg Arg Ala Arg Ser Val Ala Ser 
        195                 200                 205             


Ser Leu Arg Asp Asn Asn Pro Gln Val Asp Trp Lys Asp Trp Lys Ile 
    210                 215                 220                 


Gly Phe Gln Leu Cys Asn Gln Asn Lys Ser Asp Cys Phe Tyr Gln Thr 
225                 230                 235                 240 


Tyr Ser Ser Gly Val Asp Ala Val Arg Glu Trp Tyr Arg Phe His Tyr 
                245                 250                 255     


Ile Asn Ile Leu Ser Arg Leu Pro Glu Thr Leu Pro Ser Leu Glu Glu 
            260                 265                 270         


Asp Thr Leu Gly Asn Phe Ile Phe Ala Cys Arg Phe Asn Gln Val Ser 
        275                 280                 285             


Cys Asn Gln Ala Asn Tyr Ser His Phe His His Pro Met Tyr Gly Asn 
    290                 295                 300                 


Cys Tyr Thr Phe Asn Asp Lys Asn Asn Ser Asn Leu Trp Met Ser Ser 
305                 310                 315                 320 


Met Pro Gly Ile Asn Asn Gly Leu Ser Leu Met Leu Arg Ala Glu Gln 
                325                 330                 335     


Asn Asp Phe Ile Pro Leu Leu Ser Thr Val Thr Gly Ala Arg Val Met 
            340                 345                 350         


Val His Gly Gln Asp Glu Pro Ala Phe Met Asp Asp Gly Gly Phe Asn 
        355                 360                 365             


Leu Arg Pro Gly Val Glu Thr Ser Ile Ser Met Arg Lys Glu Thr Leu 
    370                 375                 380                 


Asp Arg Leu Gly Gly Asp Tyr Gly Asp Cys Thr Lys Asn Gly Ser Asp 
385                 390                 395                 400 


Val Pro Val Glu Asn Leu Tyr Pro Ser Lys Tyr Thr Gln Gln Val Cys 
                405                 410                 415     


Ile His Ser Cys Phe Gln Glu Ser Met Ile Lys Glu Cys Gly Cys Ala 
            420                 425                 430         


Tyr Ile Phe Tyr Pro Arg Pro Gln Asn Val Glu Tyr Cys Asp Tyr Arg 
        435                 440                 445             


Lys His Ser Ser Trp Gly Tyr Cys Tyr Tyr Lys Leu Gln Val Asp Phe 
    450                 455                 460                 


Ser Ser Asp His Leu Gly Cys Phe Thr Lys Cys Arg Lys Pro Cys Ser 
465                 470                 475                 480 


Val Thr Ser Tyr Gln Leu Ser Ala Gly Tyr Ser Arg Trp Pro Ser Val 
                485                 490                 495     


Thr Ser Gln Glu Trp Val Phe Gln Met Leu Ser Arg Gln Asn Asn Tyr 
            500                 505                 510         


Thr Val Asn Asn Lys Arg Asn Gly Val Ala Lys Val Asn Ile Phe Phe 
        515                 520                 525             


Lys Glu Leu Asn Tyr Lys Thr Asn Ser Glu Ser Pro Ser Val Thr Met 
    530                 535                 540                 


Val Thr Leu Leu Ser Asn Leu Gly Ser Gln Trp Ser Leu Trp Phe Gly 
545                 550                 555                 560 


Ser Ser Val Leu Ser Val Val Glu Met Ala Glu Leu Val Phe Asp Leu 
                565                 570                 575     


Leu Val Ile Met Phe Leu Met Leu Leu Arg Arg Phe Arg Ser Arg Tyr 
            580                 585                 590         


Trp Ser Pro Gly Arg Gly Gly Arg Gly Ala Gln Glu Val Leu Leu Glu 
        595                 600                 605             


Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His 
    610                 615                 620                 


Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr 
625                 630                 635                 640 


Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly 
                645                 650                 655     


Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys 
            660                 665                 670         


Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg 
        675                 680                 685             


His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu 
    690                 695                 700                 


Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys 
705                 710                 715                 720 


Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn 
                725                 730                 735     


Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys 
            740                 745                 750         


Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn 
        755                 760                 765             


Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys 
    770                 775                 780                 


Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly 
785                 790                 795                 800 


Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu 
                805                 810                 815     


Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys Ser 
            820                 825                 830         


Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu Gly 
        835                 840                 845             


Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser Phe 
    850                 855                 860                 


Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val Pro 
865                 870                 875                 880 


Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys Pro 
                885                 890                 895     


Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly Ala 
            900                 905                 910         


Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn Pro 
        915                 920                 925             


Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp Thr 
    930                 935                 940                 


Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro Leu 
945                 950                 955                 960 


Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu Ile 
                965                 970                 975     


Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln Tyr 
            980                 985                 990         


Ser Met Leu Ala Thr Trp Arg Arg  Arg Thr Pro Arg Arg  Glu Ala Thr 
        995                 1000                 1005             


Leu Glu  Leu Leu Gly Arg Val  Leu Arg Asp Met Asp  Leu Leu Gly 
    1010                 1015                 1020             


Cys Leu  Glu Asp Ile Glu Glu  Ala Leu Cys Gly Pro  Ala Ala Leu 
    1025                 1030                 1035             


Pro Pro  Ala Pro Ser Leu Leu  Arg 
    1040                 1045     


<210>  7
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
catcttcttc aaggagctga actaca                                            26


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
gaccagtcca ataacccctg ag                                                22


<210>  9
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  9
ctgtcacggt gctcct                                                       16


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
ccgaagccga tactggtctc                                                   20


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gaccagtcca ataacccctg ag                                                22


<210>  12
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  12
ctcaggaggt gctcct                                                       16


<210>  13
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Met Ala Arg Gly Ser Leu Thr Arg Val Pro Gly Val Met Gly 
1               5                   10                  15      


Glu Gly Thr Gln Gly Pro Glu Leu Ser Leu Asp Pro Asp Pro Cys Ser 
            20                  25                  30          


Pro Gln Ser Thr Pro Gly Leu Met Lys Gly Asn Lys Leu Glu Glu Gln 
        35                  40                  45              


Asp Pro Arg Pro Leu Gln Pro Ile Pro Gly Leu 
    50                  55                  


<210>  14
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Ser Ile Lys Gly Asn Lys Leu Glu Glu Gln Asp Pro Arg Pro 
1               5                   10                  15      


Leu Gln Pro Ile Pro Gly Leu 
            20              


