                         SEQUENCE LISTING

<110>  UNIVERSITE DE NICE SOPHIA ANTIPOLIS
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       FRELIN, Christian
       VIGNE, Paul
       TAUC, Michel
       RUBERA, Isabelle
       DURANTON, Christophe
       COUGNON, Marc
       BLONDEAU, Nicolas
 
<120>  COMPOSITION PHARMACEUTIQUE POUR AUGMENTER LA TOLERANCE HYPOXIQUE 
       CELLULAIRE

<130>  358482D28648

<150>  FR 1055910
<151>  2010-07-20

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  184
<212>  PRT
<213>  homo sapiens

<400>  1

Met Cys Gly Thr Gly Gly Thr Asp Ser Lys Thr Arg Arg Pro Pro His 
1               5                   10                  15      


Arg Ala Ser Phe Leu Lys Arg Leu Glu Ser Lys Pro Leu Lys Met Ala 
            20                  25                  30          


Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala Thr Phe 
        35                  40                  45              


Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val Leu Lys 
    50                  55                  60                  


Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr Gly Lys 
65                  70                  75                  80  


His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe Thr Gly 
                85                  90                  95      


Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp Val Pro 
            100                 105                 110         


Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp Gly Tyr 
        115                 120                 125             


Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu Arg Leu 
    130                 135                 140                 


Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp Cys Gly 
145                 150                 155                 160 


Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu Ala Ala 
                165                 170                 175     


Val Ala Ile Lys Ala Met Ala Lys 
            180                 


<210>  2
<211>  154
<212>  PRT
<213>  homo sapiens

<400>  2

Met Ala Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala 
1               5                   10                  15      


Thr Phe Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Arg Leu Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp 
        115                 120                 125             


Cys Gly Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu 
    130                 135                 140                 


Ala Ala Val Ala Ile Lys Ala Met Ala Lys 
145                 150                 


<210>  3
<211>  154
<212>  PRT
<213>  mus musculus

<400>  3

Met Ala Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala 
1               5                   10                  15      


Thr Phe Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Arg Leu Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp 
        115                 120                 125             


Cys Gly Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu 
    130                 135                 140                 


Ala Ala Val Ala Ile Lys Ala Met Ala Lys 
145                 150                 


<210>  4
<211>  154
<212>  PRT
<213>  rattus norvegicus

<400>  4

Met Ala Asp Asp Leu Asp Phe Glu Thr Gly Asp Ala Gly Ala Ser Ala 
1               5                   10                  15      


Thr Phe Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Phe Gln Leu Ile Gly Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Gln Asp Ser Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Arg Leu Pro Glu Gly Asp Leu Gly Lys Glu Ile Glu Gln Lys Tyr Asp 
        115                 120                 125             


Cys Gly Glu Glu Ile Leu Ile Thr Val Leu Ser Ala Met Thr Glu Glu 
    130                 135                 140                 


Ala Ala Val Ala Ile Lys Ala Met Ala Lys 
145                 150                 


<210>  5
<211>  153
<212>  PRT
<213>  homo sapiens

<400>  5

Met Ala Asp Glu Ile Asp Phe Thr Thr Gly Asp Ala Gly Ala Ser Ser 
1               5                   10                  15      


Thr Tyr Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Tyr Gln Leu Ile Cys Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Thr Glu Thr Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Lys Leu Pro Glu Gly Glu Leu Gly Lys Glu Ile Glu Gly Lys Tyr Asn 
        115                 120                 125             


Ala Gly Glu Asp Val Gln Val Ser Val Met Cys Ala Met Ser Glu Glu 
    130                 135                 140                 


Tyr Ala Val Ala Ile Lys Pro Cys Lys 
145                 150             


<210>  6
<211>  153
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Asp Glu Ile Asp Phe Thr Thr Gly Asp Ala Gly Ala Ser Ser 
1               5                   10                  15      


Thr Tyr Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Tyr Gln Leu Ile Cys Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Thr Glu Thr Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Lys Leu Pro Glu Gly Glu Leu Gly Lys Glu Ile Glu Gly Lys Tyr Asn 
        115                 120                 125             


Ala Gly Glu Asp Val Gln Val Ser Val Met Cys Ala Met Ser Glu Glu 
    130                 135                 140                 


Tyr Ala Val Ala Ile Lys Pro Cys Lys 
145                 150             


<210>  7
<211>  153
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Ala Asp Glu Ile Asp Phe Thr Thr Gly Asp Ala Gly Ala Ser Ser 
1               5                   10                  15      


Thr Tyr Pro Met Gln Cys Ser Ala Leu Arg Lys Asn Gly Phe Val Val 
            20                  25                  30          


Leu Lys Gly Arg Pro Cys Lys Ile Val Glu Met Ser Thr Ser Lys Thr 
        35                  40                  45              


Gly Lys His Gly His Ala Lys Val His Leu Val Gly Ile Asp Ile Phe 
    50                  55                  60                  


Thr Gly Lys Lys Tyr Glu Asp Ile Cys Pro Ser Thr His Asn Met Asp 
65                  70                  75                  80  


Val Pro Asn Ile Lys Arg Asn Asp Tyr Gln Leu Ile Cys Ile Gln Asp 
                85                  90                  95      


Gly Tyr Leu Ser Leu Leu Thr Glu Thr Gly Glu Val Arg Glu Asp Leu 
            100                 105                 110         


Lys Leu Pro Glu Gly Glu Leu Gly Lys Glu Ile Glu Gly Lys Tyr Asn 
        115                 120                 125             


Ala Gly Glu Asp Val Gln Val Ser Val Met Cys Ala Met Ser Glu Glu 
    130                 135                 140                 


Tyr Ala Val Ala Ile Lys Pro Cys Lys 
145                 150             


<210>  8
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Gly Ser Leu Glu Arg Glu Ala Pro Ala Gly Ala Leu Ala Ala 
1               5                   10                  15      


Val Leu Lys His Ser Ser Thr Leu Pro Pro Glu Ser Thr Gln Val Arg 
            20                  25                  30          


Gly Tyr Asp Phe Asn Arg Gly Val Asn Tyr Arg Ala Leu Leu Glu Ala 
        35                  40                  45              


Phe Gly Thr Thr Gly Phe Gln Ala Thr Asn Phe Gly Arg Ala Val Gln 
    50                  55                  60                  


Gln Val Asn Ala Met Ile Glu Lys Lys Leu Glu Pro Leu Ser Gln Asp 
65                  70                  75                  80  


Glu Asp Gln His Ala Asp Leu Thr Gln Ser Arg Arg Pro Leu Thr Ser 
                85                  90                  95      


Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn Leu Ile Ser Ser Gly Ile 
            100                 105                 110         


Arg Glu Thr Ile Arg Tyr Leu Val Gln His Asn Met Val Asp Val Leu 
        115                 120                 125             


Val Thr Thr Ala Gly Gly Val Glu Glu Asp Leu Ile Lys Cys Leu Ala 
    130                 135                 140                 


Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg Gly Lys Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Gly Ile Asn Arg Ile Gly Asn Leu Leu Val Pro Asn Glu Asn Tyr 
                165                 170                 175     


Cys Lys Phe Glu Asp Trp Leu Met Pro Ile Leu Asp Gln Met Val Met 
            180                 185                 190         


Glu Gln Asn Thr Glu Gly Val Lys Trp Thr Pro Ser Lys Met Ile Ala 
        195                 200                 205             


Arg Leu Gly Lys Glu Ile Asn Asn Pro Glu Ser Val Tyr Tyr Trp Ala 
    210                 215                 220                 


Gln Lys Asn His Ile Pro Val Phe Ser Pro Ala Leu Thr Asp Gly Ser 
225                 230                 235                 240 


Leu Gly Asp Met Ile Phe Phe His Ser Tyr Lys Asn Pro Gly Leu Val 
                245                 250                 255     


Leu Asp Ile Val Glu Asp Leu Arg Leu Ile Asn Thr Gln Ala Ile Phe 
            260                 265                 270         


Ala Lys Cys Thr Gly Met Ile Ile Leu Gly Gly Gly Val Val Lys His 
        275                 280                 285             


His Ile Ala Asn Ala Asn Leu Met Arg Asn Gly Ala Asp Tyr Ala Val 
    290                 295                 300                 


Tyr Ile Asn Thr Ala Gln Glu Phe Asp Gly Ser Asp Ser Gly Ala Arg 
305                 310                 315                 320 


Pro Asp Glu Ala Val Ser Trp Gly Lys Ile Arg Val Asp Ala Gln Pro 
                325                 330                 335     


Val Lys Val Tyr Ala Asp Ala Ser Leu Val Phe Pro Leu Leu Val Ala 
            340                 345                 350         


Glu Thr Phe Ala Gln Lys Met Asp Ala Phe Met His Glu Lys Asn Glu 
        355                 360                 365             


Asp 
    


<210>  9
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Gly Ser Leu Glu Arg Glu Ala Pro Ala Gly Ala Leu Ala Ala 
1               5                   10                  15      


Val Leu Lys His Ser Ser Thr Leu Pro Pro Glu Ser Thr Gln Val Arg 
            20                  25                  30          


Gly Tyr Asp Phe Asn Arg Gly Val Asn Tyr Arg Ala Leu Leu Glu Ala 
        35                  40                  45              


Phe Gly Thr Thr Gly Phe Gln Ala Thr Asn Phe Gly Arg Ala Val Gln 
    50                  55                  60                  


Gln Val Asn Ala Met Ile Glu Lys Lys Leu Glu Pro Leu Ser Gln Asp 
65                  70                  75                  80  


Glu Asp Gln His Ala Asp Leu Thr Gln Ser Arg Arg Pro Leu Thr Ser 
                85                  90                  95      


Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn Leu Ile Ser Ser Gly Ile 
            100                 105                 110         


Arg Glu Thr Ile Arg Tyr Leu Val Gln His Asn Met Val Asp Val Leu 
        115                 120                 125             


Val Thr Thr Ala Gly Gly Val Glu Glu Asp Leu Ile Lys Cys Leu Ala 
    130                 135                 140                 


Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg Gly Lys Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Gly Ile Asn Arg Ile Gly Asn Leu Leu Val Pro Asn Glu Asn Tyr 
                165                 170                 175     


Cys Lys Phe Glu Asp Trp Leu Met Pro Ile Leu Asp Gln Met Val Met 
            180                 185                 190         


Glu Gln Asn Thr Glu Gly Val Lys Trp Thr Pro Ser Lys Met Ile Ala 
        195                 200                 205             


Arg Leu Gly Lys Glu Ile Asn Asn Pro Glu Ser Val Tyr Tyr Trp Ala 
    210                 215                 220                 


Gln Lys Asn His Ile Pro Val Phe Ser Pro Ala Leu Thr Asp Gly Ser 
225                 230                 235                 240 


Leu Gly Asp Met Ile Phe Phe His Ser Tyr Lys Asn Pro Gly Leu Val 
                245                 250                 255     


Leu Asp Ile Val Glu Ala Gln Glu Phe Asp Gly Ser Asp Ser Gly Ala 
            260                 265                 270         


Arg Pro Asp Glu Ala Val Ser Trp Gly Lys Ile Arg Val Asp Ala Gln 
        275                 280                 285             


Pro Val Lys Val Tyr Ala Asp Ala Ser Leu Val Phe Pro Leu Leu Val 
    290                 295                 300                 


Ala Glu Thr Phe Ala Gln Lys Met Asp Ala Phe Met His Glu Lys Asn 
305                 310                 315                 320 


Glu Asp 
        


<210>  10
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Gly Ser Leu Glu Arg Glu Ala Pro Ala Gly Ala Leu Ala Ala 
1               5                   10                  15      


Val Leu Lys His Ser Ser Thr Leu Pro Pro Glu Ser Thr Gln Val Arg 
            20                  25                  30          


Gly Tyr Asp Phe Asn Arg Gly Val Asn Tyr Arg Ala Leu Leu Glu Ala 
        35                  40                  45              


Phe Gly Thr Thr Gly Phe Gln Ala Thr Asn Phe Gly Arg Ala Val Gln 
    50                  55                  60                  


Gln Val Asn Ala Met Ile Glu Lys Lys Leu Glu Pro Leu Ser Gln Asp 
65                  70                  75                  80  


Glu Asp Gln His Ala Asp Leu Thr Gln Ser Arg Arg Pro Leu Thr Ser 
                85                  90                  95      


Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn Leu Ile Ser Ser Gly Ile 
            100                 105                 110         


Arg Glu Thr Ile Arg Tyr Leu Val Gln His Asn Met Val Asp Val Leu 
        115                 120                 125             


Val Thr Thr Ala Gly Gly Val Glu Glu Asp Leu Ile Lys Cys Leu Ala 
    130                 135                 140                 


Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg Gly Lys Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Gly Ile Asn Arg Ile Gly Asn Leu Leu Val Pro Asn Glu Asn Tyr 
                165                 170                 175     


Cys Lys Phe Glu Asp Trp Leu Met Pro Ile Leu Asp Gln Met Val Met 
            180                 185                 190         


Glu Gln Asn Thr Glu Gly Val Lys Trp Thr Pro Ser Lys Met Ile Ala 
        195                 200                 205             


Arg Leu Gly Lys Glu Ile Asn Asn Pro Glu Ser Val Tyr Tyr Trp Ala 
    210                 215                 220                 


Gln Lys Asn His Ile Pro Val Phe Ser Pro Ala Leu Thr Asp Gly Ser 
225                 230                 235                 240 


Leu Gly Asp Met Ile Phe Phe His Ser Tyr Lys Asn Pro Gly Leu Val 
                245                 250                 255     


Leu Asp Ile Val Glu Gly Ala Arg Pro Asp Glu Ala Val Ser Trp Gly 
            260                 265                 270         


Lys Ile Arg Val Asp Ala Gln Pro Val Lys Val Tyr Ala Asp Ala Ser 
        275                 280                 285             


Leu Val Phe Pro Leu Leu Val Ala Glu Thr Phe Ala Gln Lys Met Asp 
    290                 295                 300                 


Ala Phe Met His Glu Lys Asn Glu Asp 
305                 310             


<210>  11
<211>  369
<212>  PRT
<213>  Mus musculus

<400>  11

Met Glu Gly Thr Pro Pro Gly Ala Ala Pro Ser Ser Ala Leu Ala Ala 
1               5                   10                  15      


Val Leu Lys His Ser Ser Ala Leu Pro Pro Glu Ser Ala Gln Val Gln 
            20                  25                  30          


Gly Tyr Asp Phe Asn Arg Gly Val Asp Tyr His Ala Leu Leu Asp Ala 
        35                  40                  45              


Tyr Arg Thr Thr Gly Phe Gln Ala Thr Asn Phe Gly Arg Ala Val Gln 
    50                  55                  60                  


Gln Val Asn Ala Met Ile Glu Lys Lys Leu Glu Pro Leu Ala Val Asp 
65                  70                  75                  80  


Glu Asp His His Ala Asp Leu Thr Gln Ser Arg Arg Pro Leu Thr Gly 
                85                  90                  95      


Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn Leu Ile Ser Ser Gly Ile 
            100                 105                 110         


Arg Glu Thr Ile Arg Tyr Leu Val Gln His Asn Met Val Asp Val Leu 
        115                 120                 125             


Val Thr Thr Ala Gly Gly Val Glu Glu Asp Leu Ile Lys Cys Leu Ala 
    130                 135                 140                 


Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg Gly Lys Glu Leu Arg Glu 
145                 150                 155                 160 


Ser Gly Ile Asn Arg Ile Gly Asn Leu Leu Val Pro Asn Asp Asn Tyr 
                165                 170                 175     


Cys Lys Phe Glu Asp Trp Leu Met Pro Ile Leu Asp Gln Met Val Leu 
            180                 185                 190         


Glu Gln Asn Thr Glu Gly Val Lys Trp Thr Pro Ser Lys Met Ile Ser 
        195                 200                 205             


Arg Leu Gly Lys Glu Ile Asn Asn Pro Asp Ser Val Tyr Tyr Trp Ala 
    210                 215                 220                 


His Lys Asn His Ile Pro Val Leu Ser Pro Ala Leu Thr Asp Gly Ser 
225                 230                 235                 240 


Leu Gly Asp Met Ile Phe Phe His Ser Tyr Lys Asn Pro Gly Leu Val 
                245                 250                 255     


Leu Asp Ile Val Glu Asp Leu Arg Leu Ile Asn Thr Gln Ala Ile Phe 
            260                 265                 270         


Ala Lys Arg Ser Gly Met Ile Ile Leu Gly Gly Gly Val Val Lys His 
        275                 280                 285             


His Ile Ala Asn Ala Asn Leu Met Arg Asn Gly Ala Asp Tyr Ala Val 
    290                 295                 300                 


Tyr Ile Asn Thr Ala Gln Glu Phe Asp Gly Ser Asp Ser Gly Ala Arg 
305                 310                 315                 320 


Pro Asp Glu Ala Val Ser Trp Gly Lys Ile Arg Met Asp Ala Gln Pro 
                325                 330                 335     


Val Lys Val Tyr Ala Asp Ala Ser Leu Val Phe Pro Leu Leu Val Ala 
            340                 345                 350         


Glu Thr Phe Ala Gln Lys Ala Asp Ala Phe Arg Ala Glu Lys Asn Glu 
        355                 360                 365             


Asp 
    


<210>  12
<211>  369
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Glu Gly Thr Pro Ser Gly Ala Ala Pro Ser Ser Ala Leu Ala Ala 
1               5                   10                  15      


Val Leu Lys His Ser Ser Ala Leu Pro Pro Glu Ser Ala Gln Val Gln 
            20                  25                  30          


Gly Tyr Asp Phe Asn Arg Gly Val Asp Tyr His Ala Leu Leu Glu Ala 
        35                  40                  45              


Tyr Gly Thr Thr Gly Phe Gln Ala Thr Asn Phe Gly Arg Ala Val Gln 
    50                  55                  60                  


Gln Val Asn Ala Met Ile Glu Lys Lys Leu Glu Pro Leu Ala Val Asp 
65                  70                  75                  80  


Glu Asp His His Glu Asp Leu Thr Gln Ser Arg Arg Pro Leu Thr Gly 
                85                  90                  95      


Cys Thr Ile Phe Leu Gly Tyr Thr Ser Asn Leu Ile Ser Ser Gly Ile 
            100                 105                 110         


Arg Glu Thr Ile Arg Tyr Leu Val Gln His Asn Met Val Asp Val Leu 
        115                 120                 125             


Val Thr Thr Ala Gly Gly Val Glu Glu Asp Leu Ile Lys Cys Leu Ala 
    130                 135                 140                 


Pro Thr Tyr Leu Gly Glu Phe Ser Leu Arg Gly Lys Glu Leu Arg Glu 
145                 150                 155                 160 


Asn Gly Ile Asn Arg Ile Gly Asn Leu Leu Val Pro Asn Asp Asn Tyr 
                165                 170                 175     


Cys Lys Phe Glu Asp Trp Leu Met Pro Ile Leu Asp Gln Met Val Gln 
            180                 185                 190         


Glu Gln Asn Thr Glu Gly Val Lys Trp Thr Pro Ser Lys Met Ile Ser 
        195                 200                 205             


Arg Leu Gly Lys Glu Ile Asn Asn Pro Glu Ser Val Tyr Tyr Trp Ala 
    210                 215                 220                 


His Lys Asn His Ile Pro Val Leu Ser Pro Ala Leu Thr Asp Gly Ser 
225                 230                 235                 240 


Leu Gly Asp Met Ile Phe Phe His Ser Tyr Lys Asn Pro Gly Leu Val 
                245                 250                 255     


Leu Asp Ile Val Glu Asp Leu Arg Leu Ile Asn Met Gln Ala Ile Phe 
            260                 265                 270         


Ala Lys Arg Thr Gly Met Ile Ile Leu Gly Gly Gly Val Val Lys His 
        275                 280                 285             


His Ile Ala Asn Ala Asn Leu Met Arg Asn Gly Ala Asp Tyr Ala Val 
    290                 295                 300                 


Tyr Ile Asn Thr Ala Gln Glu Phe Asp Gly Ser Asp Ser Gly Ala Arg 
305                 310                 315                 320 


Pro Asp Glu Ala Val Ser Trp Gly Lys Ile Arg Met Asp Ala Gln Pro 
                325                 330                 335     


Val Lys Val Tyr Ala Asp Ala Ser Leu Val Phe Pro Leu Leu Val Ala 
            340                 345                 350         


Glu Thr Phe Ala Gln Lys Ala Asp Ala Phe Arg Ala Glu Lys Asn Glu 
        355                 360                 365             


Asp 
    


<210>  13
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Thr Glu Gln Glu Val Asp Ala Ile Gly Gln Thr Leu Val Asp 
1               5                   10                  15      


Pro Lys Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          


Gly Leu Gly Gly Pro Gly Ala Ile Ala Trp Ile Ser Gln Ala Phe Asp 
        35                  40                  45              


Asp Asp Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  


Met Gln Asp Ala Arg Ala Ile Pro Met Leu Val Asp Val Leu Gln Asp 
65                  70                  75                  80  


Thr Arg Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      


Ala Ile Gly Asp Pro Glu Val Leu Glu Ile Leu Lys Gln Tyr Ser Ser 
            100                 105                 110         


Asp Pro Val Ile Glu Val Ala Glu Thr Cys Gln Leu Ala Val Arg Arg 
        115                 120                 125             


Leu Glu Trp Leu Gln Gln His Gly Gly Glu Pro Ala Ala Gly Pro Tyr 
    130                 135                 140                 


Leu Ser Val Asp Pro Ala Pro Pro Ala Glu Glu Arg Asp Val Gly Arg 
145                 150                 155                 160 


Leu Arg Glu Ala Leu Leu Asp Glu Ser Arg Pro Leu Phe Glu Arg Tyr 
                165                 170                 175     


Arg Ala Met Phe Ala Leu Arg Asn Ala Gly Gly Glu Glu Ala Ala Leu 
            180                 185                 190         


Ala Leu Ala Glu Gly Leu His Cys Gly Ser Ala Leu Phe Arg His Glu 
        195                 200                 205             


Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Pro Gln 
    210                 215                 220                 


Leu Ala Ala Ala Leu Ala Arg Cys Thr Glu Asn Pro Met Val Arg His 
225                 230                 235                 240 


Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu Ala 
                245                 250                 255     


Ala Leu Gln Ala His Ala Asp Asp Pro Glu Arg Val Val Arg Glu Ser 
            260                 265                 270         


Cys Glu Val Ala Leu Asp Met Tyr Glu His Glu Thr Gly Arg Ala Phe 
        275                 280                 285             


Gln Tyr Ala Asp Gly Leu Glu Gln Leu Arg Gly Ala Pro Ser 
    290                 295                 300         


<210>  14
<211>  302
<212>  PRT
<213>  Mus musculus

<400>  14

Met Val Thr Glu Gln Glu Ile Glu Ala Ile Gly Lys Thr Leu Val Asp 
1               5                   10                  15      


Pro Lys Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          


Gly Leu Gly Gly Pro Asp Ala Ile Ser Trp Ile Ser Arg Gly Phe Glu 
        35                  40                  45              


Asp Ser Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  


Met Arg Asp Ala Arg Ala Ile Pro Val Leu Ala Asp Val Leu Gln Asp 
65                  70                  75                  80  


Thr Ser Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      


Ala Ile Gly Asn Pro Glu Val Leu Gly Leu Leu Lys Gln Tyr Ser Thr 
            100                 105                 110         


Asp Pro Val Val Glu Val Ala Glu Thr Cys Gln Leu Ala Val Gly Arg 
        115                 120                 125             


Leu Glu Trp Leu Gln Gln His Pro Gly Glu Ala Thr Cys Ala Gly Pro 
    130                 135                 140                 


Tyr Leu Ser Val Asp Pro Ala Pro Pro Ala Ala Glu Gln Asp Val Gly 
145                 150                 155                 160 


Arg Leu Arg Glu Ala Leu Leu Asp Glu Ala Arg Pro Leu Phe Glu Arg 
                165                 170                 175     


Tyr Arg Ala Met Phe Ala Leu Arg Asn Val Gly Gly Lys Glu Ala Ala 
            180                 185                 190         


Leu Ala Leu Ala Glu Gly Leu Gln Cys Gly Ser Ala Leu Phe Arg His 
        195                 200                 205             


Glu Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Pro 
    210                 215                 220                 


Gly Leu Ala Ala Thr Leu Ala Arg Thr Thr Glu Ser Pro Met Val Arg 
225                 230                 235                 240 


His Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu 
                245                 250                 255     


Ala Ala Leu Arg Glu His Ile Glu Asp Pro Glu Gln Val Val Arg Glu 
            260                 265                 270         


Ser Cys Glu Val Ala Leu Asp Met Tyr Glu Tyr Glu Ser Ser Gln Asp 
        275                 280                 285             


Phe Gln Tyr Ala Asp Gly Leu Glu Arg Leu Arg Pro Pro Pro 
    290                 295                 300         


<210>  15
<211>  302
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Val Thr Glu Gln Glu Val Glu Ala Ile Gly Lys Thr Leu Val Asp 
1               5                   10                  15      


Ser Thr Gln Pro Leu Gln Ala Arg Phe Arg Ala Leu Phe Thr Leu Arg 
            20                  25                  30          


Gly Leu Gly Gly Pro Asp Ala Ile Ser Trp Ile Ser Arg Gly Phe Glu 
        35                  40                  45              


Asp Ser Ser Ala Leu Leu Lys His Glu Leu Ala Tyr Cys Leu Gly Gln 
    50                  55                  60                  


Met Arg Asp Pro Arg Ala Ile Pro Val Leu Val Ser Val Leu Gln Asp 
65                  70                  75                  80  


Arg Asn Gln Glu Pro Met Val Arg His Glu Ala Gly Glu Ala Leu Gly 
                85                  90                  95      


Ala Ile Gly Asn Pro Lys Val Leu Gly Leu Leu Lys Gln Tyr Ser Thr 
            100                 105                 110         


Asp Pro Val Val Glu Val Ala Glu Thr Cys Gln Leu Ala Val Arg Arg 
        115                 120                 125             


Leu Glu Trp Leu Gln Gln His Pro Gly Glu Ala Thr Cys Ala Gly Pro 
    130                 135                 140                 


Tyr Leu Ser Val Asp Pro Ala Pro Pro Ala Ala Glu Gly Asp Val Gly 
145                 150                 155                 160 


Arg Leu Arg Glu Thr Leu Leu Asp Glu Ala Gln Pro Leu Phe Glu Arg 
                165                 170                 175     


Tyr Arg Ala Met Phe Ala Leu Arg Asn Val Gly Gly Lys Glu Ala Ala 
            180                 185                 190         


Leu Ala Leu Ala Glu Gly Leu Lys Cys Gly Ser Ala Leu Phe Arg His 
        195                 200                 205             


Glu Val Gly Tyr Val Leu Gly Gln Leu Gln His Glu Ala Ala Val Ser 
    210                 215                 220                 


Glu Leu Ala Ala Thr Leu Ala Arg Thr Thr Glu Ser Pro Met Val Arg 
225                 230                 235                 240 


His Glu Cys Ala Glu Ala Leu Gly Ala Ile Ala Arg Pro Ala Cys Leu 
                245                 250                 255     


Ala Ala Leu Arg Glu Tyr Ile Thr Asp Pro Glu Arg Val Val Arg Glu 
            260                 265                 270         


Ser Cys Glu Val Ala Leu Asp Met Tyr Glu Tyr Glu Asn Gly Gln Asp 
        275                 280                 285             


Phe Gln Tyr Ala Asp Gly Leu Glu Arg Leu Arg Pro Pro Pro 
    290                 295                 300         


