                         SEQUENCE LISTING

<110>  Roche Glycart AG
 
<120>  ANTI-CXCR5 ANTIBODIES AND METHODS OF USE

<130>  26843 WO

<150>  EP10170349
<151>  2010-07-21

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  1

Thr Asn Ala Met Asn 
1               5   


<210>  2
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  2

Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  3
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ile Pro Phe Ala Tyr 
1               5       


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  4

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Trp Ala Ser Thr Arg Asp Ser 
1               5           


<210>  6
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  6

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  7
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  7

Thr Asn Ala Met Asn 
1               5   


<210>  8
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Ile Arg Ser Lys Asn Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  9
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ile Pro Phe Ala Tyr 
1               5       


<210>  10
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  10

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  13
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  13

Thr Asn Ala Met Asn 
1               5   


<210>  14
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  14

Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
1               5                   10                  15  


<210>  15
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ile Pro Phe Ala Tyr 
1               5       


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHh2C9

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Thr Met Ile Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h2C9 CDRL1

<400>  17

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  18
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  18

Trp Ala Ser Thr Arg Asp Ser 
1               5           


<210>  19
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  19

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLh2C9

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  21

Thr Asn Ala Met Asn 
1               5   


<210>  22
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h2B5 CDRH2

<400>  22

Arg Ile Arg Ser Lys Asn Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210>  23
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  23

Met Ile Pro Phe Ala Tyr 
1               5       


<210>  24
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHh2B5

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Thr Met Ile Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  h2B5 CDRL1

<400>  25

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  26
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  26

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  27
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  27

His Gln Tyr Leu Ser Ser Tyr Thr 
1               5               


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLh2B5

<400>  28

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      


Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer 1

<400>  30
gctcagagtg tagaggtcag actgc                                             25


<210>  31
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer 2

<400>  31
gaagctcttg acaatgggtg aagttg                                            26


<210>  32
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  32

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  33
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  34
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


