                         SEQUENCE LISTING

<110>  IDD BIOTECH (INTERNATIONAL - DRUG - DEVELOPMENT - BIOTECH)
 
<120>  ANTI-CD19 ANTIBODY HAVING ADCC AND CDC FUNCTIONS AND IMPROVED 
       GLYCOSYLATION PROFILE

<130>  BET10L1028

<140>  EP 10/305796
<141>  2010-07-19

<160>  36    

<170>  PatentIn version 3.4

<210>  1
<211>  330
<212>  PRT
<213>  artificial sequence 

<220>
<223>  Fc34

<400>  1

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Leu Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Pro Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Leu Arg Val Val Ser Leu Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Ala Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Leu Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  2
<211>  993
<212>  DNA
<213>  artificial sequence

<220>
<223>  Fc34

<400>  2
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttacc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgccggagga gcagtacaac    540

agcacgctcc gtgtggtcag cctcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacgcagcc ctcccagccc ccatcgagaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag    720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctctcgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa tga                                 993


<210>  3
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc24

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Leu Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Pro Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Leu Arg Val Val Ser Leu Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Ala Ala Leu Pro Ala Pro Ile Ala Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Leu Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  4
<211>  993
<212>  DNA
<213>  artificial sequence 

<220>
<223>  Fc24

<400>  4
gcctccacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg     60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg    120

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca    180

ggactctact ccctcagcag cgtcgtgacc gtgccctcca gcagcttggg cacccagacc    240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc    300

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga    360

ccgtcagtct tcctcttacc cccaaaaccc aaggacaccc tcatgatctc ccggacccct    420

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg    480

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgccggagga gcagtacaac    540

agcacgctcc gtgtggtcag cctcctcacc gtcctgcacc aggactggct gaatggcaag    600

gagtacaagt gcaaggtctc caacgcagcc ctcccagccc ccatcgcgaa aaccatctcc    660

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag    720

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc    780

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctctcgtg    840

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg    900

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    960

cagaagagcc tctccctgtc tccgggtaaa tga                                 993


<210>  5
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  5

Gly Tyr Ala Phe Ser Ser Tyr Trp 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  6

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  7
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  7

Ala Arg Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr 
1               5                   10                  


<210>  8
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  8

Asp His Ile Asn Asn Trp 
1               5       


<210>  9
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  9

Gly Ala Thr 
1           


<210>  10
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  10

Gln Gln Ser Trp Asn Thr Pro Trp Thr 
1               5                   


<210>  11
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  11

Ser Tyr Trp Val Asn 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  12

Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  13
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  13

Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr 
1               5                   10          


<210>  14
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  14

Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala 
1               5                   10      


<210>  15
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  15

Gly Ala Thr Thr Leu Glu Thr 
1               5           


<210>  16
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  16

Ser Ser Tyr Trp 
1               


<210>  17
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  17

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  18

Val Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  19
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  19

Ala Arg Gly Pro Tyr Tyr Tyr Gly Ser Ser Pro Phe Asp Tyr 
1               5                   10                  


<210>  20
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  20

Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  21
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  21

Arg Val Ser 
1           


<210>  22
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  22

Leu Gln Val Thr His Val Pro Pro Thr 
1               5                   


<210>  23
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  23

Ser Tyr Val Met His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  24

Tyr Val Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  25

Gly Pro Tyr Tyr Tyr Gly Ser Ser Pro Phe Asp Tyr 
1               5                   10          


<210>  26
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  26

Arg Ser Ser Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  27
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  27

Arg Val Ser Asn Arg Phe Ser 
1               5           


<210>  28
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  28

Thr Ser Tyr Val 
1               


<210>  29
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  protein

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Val Asn Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Val Thr Ala Asp Lys Ser Ser Ser Thr Ser Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Ile Thr Thr Val Val Gly Cys Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  30
<211>  363
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA

<400>  30
caggtccagc tgcagcagtc tggggctgaa ctggtgaggc ctgggtcctc agtgaagatt     60

tcctgtaagg cttctggcta tgcattcagt agctactggg tgaactggat gaagcagagg    120

cctggacagg gacttgagtg gattggacag atttaccctg gagatggtga tactaattac    180

aatggaaagt tcaagggtcg agccacagtg actgcagaca aatcctccag cacatcctac    240

atgcagttca gcagcctaac atctgaggac tctgcggtct atttctgtgc aagatctatt    300

actacggtgg taggctgtgc tatggactac tggggtcaag gaacctcggt caccgtctcc    360

tca                                                                  363


<210>  31
<211>  103
<212>  PRT
<213>  artificial sequence 

<220>
<223>  peptide

<400>  31

Asp Ile Gln Met Thr Gln Ser Ser Ala Tyr Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln His Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Gly Ala Thr Thr Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Trp Asn Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys 
            100             


<210>  32
<211>  309
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA

<400>  32
gacattcaga tgacccagtc ttctgcctac ctgtctgtat ctctaggagg cagggtcacc     60

attacttgca aggcaagtga ccacattaat aattggttag cctggtatca acataaacca    120

ggaaatgctc ctaggctctt aatatctggt gcaaccactt tggaaactgg ggttccttca    180

agattcagtg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact    240

gaagatgttg ctacttatta ctgtcaacag tcttggaata ctccgtggac gttcggtgga    300

ggcaccaag                                                            309


<210>  33
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  protein

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Tyr Tyr Tyr Gly Ser Ser Pro Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Gln Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA

<400>  34
gaggttcagc tgcaacagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg     60

tcctgcaagg cttctggata cacattcact agctatgtta tgcactgggt gaagcagaag    120

cctgggcagg gccttgagtg gattggatat gttaatcctt acaatgatgg tactaagtac    180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac    240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagagggcct    300

tattactacg gtagtagccc ctttgactac tggggccaag gccaggtcac cgtctcctca    360


<210>  35
<211>  108
<212>  PRT
<213>  artificial sequence

<220>
<223>  protein

<400>  35

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Ala Gly Thr Lys 
            100                 105             


<210>  36
<211>  324
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA

<400>  36
gacgctgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc     60

atctcttgca ggtctagtca gagccttgaa aacagtaatg gaaacaccta tttgaactgg    120

tacctccaga aaccaggcca gtctccacag ctcctgatct acagggtttc caaccgattt    180

tctggggtcc tagacaggtt cagtggtagt ggatcaggga cagatttcac actgaaaatc    240

agcagagtgg aggctgagga tttgggagtt tatttctgcc tccaagttac acatgtccct    300

cccacgttcg gtgctgggac caag                                           324


