                         SEQUENCE LISTING

<110>  Fang, Ye
 
<120>  Label-free Cellular Pharmacology For Drug Antitarget Assessment

<130>  SP10-200

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1159
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(1159)

<400>  1

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  2
<211>  888
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(888)

<400>  2

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Met Gly Trp Gly Ala Gly Thr Gly Leu Glu Met Pro Ser Ala Ala Ser 
                805                 810                 815     


Arg Gly Ala Ser Leu Leu Asn Met Gln Ser Leu Gly Leu Trp Thr Trp 
            820                 825                 830         


Asp Cys Leu Gln Gly His Trp Ala Pro Leu Ile His Leu Asn Ser Gly 
        835                 840                 845             


Pro Pro Ser Gly Ala Met Glu Arg Ser Pro Thr Trp Gly Glu Ala Ala 
    850                 855                 860                 


Glu Leu Trp Gly Ser His Ile Leu Leu Pro Phe Arg Ile Arg His Lys 
865                 870                 875                 880 


Gln Thr Leu Phe Ala Ser Leu Lys 
                885             


<210>  3
<211>  466
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(466)

<400>  3

Met Val Phe Leu Ser Gly Asn Ala Ser Asp Ser Ser Asn Cys Thr Gln 
1               5                   10                  15      


Pro Pro Ala Pro Val Asn Ile Ser Lys Ala Ile Leu Leu Gly Val Ile 
            20                  25                  30          


Leu Gly Gly Leu Ile Leu Phe Gly Val Leu Gly Asn Ile Leu Val Ile 
        35                  40                  45              


Leu Ser Val Ala Cys His Arg His Leu His Ser Val Thr His Tyr Tyr 
    50                  55                  60                  


Ile Val Asn Leu Ala Val Ala Asp Leu Leu Leu Thr Ser Thr Val Leu 
65                  70                  75                  80  


Pro Phe Ser Ala Ile Phe Glu Val Leu Gly Tyr Trp Ala Phe Gly Arg 
                85                  90                  95      


Val Phe Cys Asn Ile Trp Ala Ala Val Asp Val Leu Cys Cys Thr Ala 
            100                 105                 110         


Ser Ile Met Gly Leu Cys Ile Ile Ser Ile Asp Arg Tyr Ile Gly Val 
        115                 120                 125             


Ser Tyr Pro Leu Arg Tyr Pro Thr Ile Val Thr Gln Arg Arg Gly Leu 
    130                 135                 140                 


Met Ala Leu Leu Cys Val Trp Ala Leu Ser Leu Val Ile Ser Ile Gly 
145                 150                 155                 160 


Pro Leu Phe Gly Trp Arg Gln Pro Ala Pro Glu Asp Glu Thr Ile Cys 
                165                 170                 175     


Gln Ile Asn Glu Glu Pro Gly Tyr Val Leu Phe Ser Ala Leu Gly Ser 
            180                 185                 190         


Phe Tyr Leu Pro Leu Ala Ile Ile Leu Val Met Tyr Cys Arg Val Tyr 
        195                 200                 205             


Val Val Ala Lys Arg Glu Ser Arg Gly Leu Lys Ser Gly Leu Lys Thr 
    210                 215                 220                 


Asp Lys Ser Asp Ser Glu Gln Val Thr Leu Arg Ile His Arg Lys Asn 
225                 230                 235                 240 


Ala Pro Ala Gly Gly Ser Gly Met Ala Ser Ala Lys Thr Lys Thr His 
                245                 250                 255     


Phe Ser Val Arg Leu Leu Lys Phe Ser Arg Glu Lys Lys Ala Ala Lys 
            260                 265                 270         


Thr Leu Gly Ile Val Val Gly Cys Phe Val Leu Cys Trp Leu Pro Phe 
        275                 280                 285             


Phe Leu Val Met Pro Ile Gly Ser Phe Phe Pro Asp Phe Lys Pro Ser 
    290                 295                 300                 


Glu Thr Val Phe Lys Ile Val Phe Trp Leu Gly Tyr Leu Asn Ser Cys 
305                 310                 315                 320 


Ile Asn Pro Ile Ile Tyr Pro Cys Ser Ser Gln Glu Phe Lys Lys Ala 
                325                 330                 335     


Phe Gln Asn Val Leu Arg Ile Gln Cys Leu Cys Arg Lys Gln Ser Ser 
            340                 345                 350         


Lys His Ala Leu Gly Tyr Thr Leu His Pro Pro Ser Gln Ala Val Glu 
        355                 360                 365             


Gly Gln His Lys Asp Met Val Arg Ile Pro Val Gly Ser Arg Glu Thr 
    370                 375                 380                 


Phe Tyr Arg Ile Ser Lys Thr Asp Gly Val Cys Glu Trp Lys Phe Phe 
385                 390                 395                 400 


Ser Ser Met Pro Arg Gly Ser Ala Arg Ile Thr Val Ser Lys Asp Gln 
                405                 410                 415     


Ser Ser Cys Thr Thr Ala Arg Val Arg Ser Lys Ser Phe Leu Gln Val 
            420                 425                 430         


Cys Cys Cys Val Gly Pro Ser Thr Pro Ser Leu Asp Lys Asn His Gln 
        435                 440                 445             


Val Pro Thr Ile Lys Val His Thr Ile Ser Leu Ser Glu Asn Gly Glu 
    450                 455                 460                 


Glu Val 
465     


<210>  4
<211>  443
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(443)

<400>  4

Met Asp Pro Leu Asn Leu Ser Trp Tyr Asp Asp Asp Leu Glu Arg Gln 
1               5                   10                  15      


Asn Trp Ser Arg Pro Phe Asn Gly Ser Asp Gly Lys Ala Asp Arg Pro 
            20                  25                  30          


His Tyr Asn Tyr Tyr Ala Thr Leu Leu Thr Leu Leu Ile Ala Val Ile 
        35                  40                  45              


Val Phe Gly Asn Val Leu Val Cys Met Ala Val Ser Arg Glu Lys Ala 
    50                  55                  60                  


Leu Gln Thr Thr Thr Asn Tyr Leu Ile Val Ser Leu Ala Val Ala Asp 
65                  70                  75                  80  


Leu Leu Val Ala Thr Leu Val Met Pro Trp Val Val Tyr Leu Glu Val 
                85                  90                  95      


Val Gly Glu Trp Lys Phe Ser Arg Ile His Cys Asp Ile Phe Val Thr 
            100                 105                 110         


Leu Asp Val Met Met Cys Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile 
        115                 120                 125             


Ser Ile Asp Arg Tyr Thr Ala Val Ala Met Pro Met Leu Tyr Asn Thr 
    130                 135                 140                 


Arg Tyr Ser Ser Lys Arg Arg Val Thr Val Met Ile Ser Ile Val Trp 
145                 150                 155                 160 


Val Leu Ser Phe Thr Ile Ser Cys Pro Leu Leu Phe Gly Leu Asn Asn 
                165                 170                 175     


Ala Asp Gln Asn Glu Cys Ile Ile Ala Asn Pro Ala Phe Val Val Tyr 
            180                 185                 190         


Ser Ser Ile Val Ser Phe Tyr Val Pro Phe Ile Val Thr Leu Leu Val 
        195                 200                 205             


Tyr Ile Lys Ile Tyr Ile Val Leu Arg Arg Arg Arg Lys Arg Val Asn 
    210                 215                 220                 


Thr Lys Arg Ser Ser Arg Ala Phe Arg Ala His Leu Arg Ala Pro Leu 
225                 230                 235                 240 


Lys Gly Asn Cys Thr His Pro Glu Asp Met Lys Leu Cys Thr Val Ile 
                245                 250                 255     


Met Lys Ser Asn Gly Ser Phe Pro Val Asn Arg Arg Arg Val Glu Ala 
            260                 265                 270         


Ala Arg Arg Ala Gln Glu Leu Glu Met Glu Met Leu Ser Ser Thr Ser 
        275                 280                 285             


Pro Pro Glu Arg Thr Arg Tyr Ser Pro Ile Pro Pro Ser His His Gln 
    290                 295                 300                 


Leu Thr Leu Pro Asp Pro Ser His His Gly Leu His Ser Thr Pro Asp 
305                 310                 315                 320 


Ser Pro Ala Lys Pro Glu Lys Asn Gly His Ala Lys Asp His Pro Lys 
                325                 330                 335     


Ile Ala Lys Ile Phe Glu Ile Gln Thr Met Pro Asn Gly Lys Thr Arg 
            340                 345                 350         


Thr Ser Leu Lys Thr Met Ser Arg Arg Lys Leu Ser Gln Gln Lys Glu 
        355                 360                 365             


Lys Lys Ala Thr Gln Met Leu Ala Ile Val Leu Gly Val Phe Ile Ile 
    370                 375                 380                 


Cys Trp Leu Pro Phe Phe Ile Thr His Ile Leu Asn Ile His Cys Asp 
385                 390                 395                 400 


Cys Asn Ile Pro Pro Val Leu Tyr Ser Ala Phe Thr Trp Leu Gly Tyr 
                405                 410                 415     


Val Asn Ser Ala Val Asn Pro Ile Ile Tyr Thr Thr Phe Asn Ile Glu 
            420                 425                 430         


Phe Arg Lys Ala Phe Leu Lys Ile Leu His Cys 
        435                 440             


<210>  5
<211>  471
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(471)

<400>  5

Met Asp Ile Leu Cys Glu Glu Asn Thr Ser Leu Ser Ser Thr Thr Asn 
1               5                   10                  15      


Ser Leu Met Gln Leu Asn Asp Asp Thr Arg Leu Tyr Ser Asn Asp Phe 
            20                  25                  30          


Asn Ser Gly Glu Ala Asn Thr Ser Asp Ala Phe Asn Trp Thr Val Asp 
        35                  40                  45              


Ser Glu Asn Arg Thr Asn Leu Ser Cys Glu Gly Cys Leu Ser Pro Ser 
    50                  55                  60                  


Cys Leu Ser Leu Leu His Leu Gln Glu Lys Asn Trp Ser Ala Leu Leu 
65                  70                  75                  80  


Thr Ala Val Val Ile Ile Leu Thr Ile Ala Gly Asn Ile Leu Val Ile 
                85                  90                  95      


Met Ala Val Ser Leu Glu Lys Lys Leu Gln Asn Ala Thr Asn Tyr Phe 
            100                 105                 110         


Leu Met Ser Leu Ala Ile Ala Asp Met Leu Leu Gly Phe Leu Val Met 
        115                 120                 125             


Pro Val Ser Met Leu Thr Ile Leu Tyr Gly Tyr Arg Trp Pro Leu Pro 
    130                 135                 140                 


Ser Lys Leu Cys Ala Val Trp Ile Tyr Leu Asp Val Leu Phe Ser Thr 
145                 150                 155                 160 


Ala Ser Ile Met His Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala 
                165                 170                 175     


Ile Gln Asn Pro Ile His His Ser Arg Phe Asn Ser Arg Thr Lys Ala 
            180                 185                 190         


Phe Leu Lys Ile Ile Ala Val Trp Thr Ile Ser Val Gly Ile Ser Met 
        195                 200                 205             


Pro Ile Pro Val Phe Gly Leu Gln Asp Asp Ser Lys Val Phe Lys Glu 
    210                 215                 220                 


Gly Ser Cys Leu Leu Ala Asp Asp Asn Phe Val Leu Ile Gly Ser Phe 
225                 230                 235                 240 


Val Ser Phe Phe Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Phe Leu 
                245                 250                 255     


Thr Ile Lys Ser Leu Gln Lys Glu Ala Thr Leu Cys Val Ser Asp Leu 
            260                 265                 270         


Gly Thr Arg Ala Lys Leu Ala Ser Phe Ser Phe Leu Pro Gln Ser Ser 
        275                 280                 285             


Leu Ser Ser Glu Lys Leu Phe Gln Arg Ser Ile His Arg Glu Pro Gly 
    290                 295                 300                 


Ser Tyr Thr Gly Arg Arg Thr Met Gln Ser Ile Ser Asn Glu Gln Lys 
305                 310                 315                 320 


Ala Cys Lys Val Leu Gly Ile Val Phe Phe Leu Phe Val Val Met Trp 
                325                 330                 335     


Cys Pro Phe Phe Ile Thr Asn Ile Met Ala Val Ile Cys Lys Glu Ser 
            340                 345                 350         


Cys Asn Glu Asp Val Ile Gly Ala Leu Leu Asn Val Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Leu Ser Ser Ala Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Tyr Arg Ser Ala Phe Ser Arg Tyr Ile Gln Cys Gln Tyr Lys 
385                 390                 395                 400 


Glu Asn Lys Lys Pro Leu Gln Leu Ile Leu Val Asn Thr Ile Pro Ala 
                405                 410                 415     


Leu Ala Tyr Lys Ser Ser Gln Leu Gln Met Gly Gln Lys Lys Asn Ser 
            420                 425                 430         


Lys Gln Asp Ala Lys Thr Thr Asp Asn Asp Cys Ser Met Val Ala Leu 
        435                 440                 445             


Gly Lys Gln His Ser Glu Glu Ala Ser Lys Asp Asn Ser Asp Gly Val 
    450                 455                 460                 


Asn Glu Lys Val Ser Cys Val 
465                 470     


<210>  6
<211>  458
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(458)

<400>  6

Met Val Asn Leu Arg Asn Ala Val His Ser Phe Leu Val His Leu Ile 
1               5                   10                  15      


Gly Leu Leu Val Trp Gln Cys Asp Ile Ser Val Ser Pro Val Ala Ala 
            20                  25                  30          


Ile Val Thr Asp Ile Phe Asn Thr Ser Asp Gly Gly Arg Phe Lys Phe 
        35                  40                  45              


Pro Asp Gly Val Gln Asn Trp Pro Ala Leu Ser Ile Val Ile Ile Ile 
    50                  55                  60                  


Ile Met Thr Ile Gly Gly Asn Ile Leu Val Ile Met Ala Val Ser Met 
65                  70                  75                  80  


Glu Lys Lys Leu His Asn Ala Thr Asn Tyr Phe Leu Met Ser Leu Ala 
                85                  90                  95      


Ile Ala Asp Met Leu Val Gly Leu Leu Val Met Pro Leu Ser Leu Leu 
            100                 105                 110         


Ala Ile Leu Tyr Asp Tyr Val Trp Pro Leu Pro Arg Tyr Leu Cys Pro 
        115                 120                 125             


Val Trp Ile Ser Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met His 
    130                 135                 140                 


Leu Cys Ala Ile Ser Leu Asp Arg Tyr Val Ala Ile Arg Asn Pro Ile 
145                 150                 155                 160 


Glu His Ser Arg Phe Asn Ser Arg Thr Lys Ala Ile Met Lys Ile Ala 
                165                 170                 175     


Ile Val Trp Ala Ile Ser Ile Gly Val Ser Val Pro Ile Pro Val Ile 
            180                 185                 190         


Gly Leu Arg Asp Glu Glu Lys Val Phe Val Asn Asn Thr Thr Cys Val 
        195                 200                 205             


Leu Asn Asp Pro Asn Phe Val Leu Ile Gly Ser Phe Val Ala Phe Phe 
    210                 215                 220                 


Ile Pro Leu Thr Ile Met Val Ile Thr Tyr Cys Leu Thr Ile Tyr Val 
225                 230                 235                 240 


Leu Arg Arg Gln Ala Leu Met Leu Leu His Gly His Thr Glu Glu Pro 
                245                 250                 255     


Pro Gly Leu Ser Leu Asp Phe Leu Lys Cys Cys Lys Arg Asn Thr Ala 
            260                 265                 270         


Glu Glu Glu Asn Ser Ala Asn Pro Asn Gln Asp Gln Asn Ala Arg Arg 
        275                 280                 285             


Arg Lys Lys Lys Glu Arg Arg Pro Arg Gly Thr Met Gln Ala Ile Asn 
    290                 295                 300                 


Asn Glu Arg Lys Ala Ser Lys Val Leu Gly Ile Val Phe Phe Val Phe 
305                 310                 315                 320 


Leu Ile Met Trp Cys Pro Phe Phe Ile Thr Asn Ile Leu Ser Val Leu 
                325                 330                 335     


Cys Glu Lys Ser Cys Asn Gln Lys Leu Met Glu Lys Leu Leu Asn Val 
            340                 345                 350         


Phe Val Trp Ile Gly Tyr Val Cys Ser Gly Ile Asn Pro Leu Val Tyr 
        355                 360                 365             


Thr Leu Phe Asn Lys Ile Tyr Arg Arg Ala Phe Ser Asn Tyr Leu Arg 
    370                 375                 380                 


Cys Asn Tyr Lys Val Glu Lys Lys Pro Pro Val Arg Gln Ile Pro Arg 
385                 390                 395                 400 


Val Ala Ala Thr Ala Leu Ser Gly Arg Glu Leu Asn Val Asn Ile Tyr 
                405                 410                 415     


Arg His Thr Asn Glu Pro Val Ile Glu Lys Ala Ser Asp Asn Glu Pro 
            420                 425                 430         


Gly Ile Glu Met Gln Val Glu Asn Leu Glu Leu Pro Val Asn Pro Ser 
        435                 440                 445             


Ser Val Val Ser Glu Arg Ile Ser Ser Val 
    450                 455             


<210>  7
<211>  460
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(460)

<400>  7

Met Asn Thr Ser Ala Pro Pro Ala Val Ser Pro Asn Ile Thr Val Leu 
1               5                   10                  15      


Ala Pro Gly Lys Gly Pro Trp Gln Val Ala Phe Ile Gly Ile Thr Thr 
            20                  25                  30          


Gly Leu Leu Ser Leu Ala Thr Val Thr Gly Asn Leu Leu Val Leu Ile 
        35                  40                  45              


Ser Phe Lys Val Asn Thr Glu Leu Lys Thr Val Asn Asn Tyr Phe Leu 
    50                  55                  60                  


Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly Thr Phe Ser Met Asn 
65                  70                  75                  80  


Leu Tyr Thr Thr Tyr Leu Leu Met Gly His Trp Ala Leu Gly Thr Leu 
                85                  90                  95      


Ala Cys Asp Leu Trp Leu Ala Leu Asp Tyr Val Ala Ser Asn Ala Ser 
            100                 105                 110         


Val Met Asn Leu Leu Leu Ile Ser Phe Asp Arg Tyr Phe Ser Val Thr 
        115                 120                 125             


Arg Pro Leu Ser Tyr Arg Ala Lys Arg Thr Pro Arg Arg Ala Ala Leu 
    130                 135                 140                 


Met Ile Gly Leu Ala Trp Leu Val Ser Phe Val Leu Trp Ala Pro Ala 
145                 150                 155                 160 


Ile Leu Phe Trp Gln Tyr Leu Val Gly Glu Arg Thr Val Leu Ala Gly 
                165                 170                 175     


Gln Cys Tyr Ile Gln Phe Leu Ser Gln Pro Ile Ile Thr Phe Gly Thr 
            180                 185                 190         


Ala Met Ala Ala Phe Tyr Leu Pro Val Thr Val Met Cys Thr Leu Tyr 
        195                 200                 205             


Trp Arg Ile Tyr Arg Glu Thr Glu Asn Arg Ala Arg Glu Leu Ala Ala 
    210                 215                 220                 


Leu Gln Gly Ser Glu Thr Pro Gly Lys Gly Gly Gly Ser Ser Ser Ser 
225                 230                 235                 240 


Ser Glu Arg Ser Gln Pro Gly Ala Glu Gly Ser Pro Glu Thr Pro Pro 
                245                 250                 255     


Gly Arg Cys Cys Arg Cys Cys Arg Ala Pro Arg Leu Leu Gln Ala Tyr 
            260                 265                 270         


Ser Trp Lys Glu Glu Glu Glu Glu Asp Glu Gly Ser Met Glu Ser Leu 
        275                 280                 285             


Thr Ser Ser Glu Gly Glu Glu Pro Gly Ser Glu Val Val Ile Lys Met 
    290                 295                 300                 


Pro Met Val Asp Pro Glu Ala Gln Ala Pro Thr Lys Gln Pro Pro Arg 
305                 310                 315                 320 


Ser Ser Pro Asn Thr Val Lys Arg Pro Thr Lys Lys Gly Arg Asp Arg 
                325                 330                 335     


Ala Gly Lys Gly Gln Lys Pro Arg Gly Lys Glu Gln Leu Ala Lys Arg 
            340                 345                 350         


Lys Thr Phe Ser Leu Val Lys Glu Lys Lys Ala Ala Arg Thr Leu Ser 
        355                 360                 365             


Ala Ile Leu Leu Ala Phe Ile Leu Thr Trp Thr Pro Tyr Asn Ile Met 
    370                 375                 380                 


Val Leu Val Ser Thr Phe Cys Lys Asp Cys Val Pro Glu Thr Leu Trp 
385                 390                 395                 400 


Glu Leu Gly Tyr Trp Leu Cys Tyr Val Asn Ser Thr Ile Asn Pro Met 
                405                 410                 415     


Cys Tyr Ala Leu Cys Asn Lys Ala Phe Arg Asp Thr Phe Arg Leu Leu 
            420                 425                 430         


Leu Leu Cys Arg Trp Asp Lys Arg Arg Trp Arg Lys Ile Pro Lys Arg 
        435                 440                 445             


Pro Gly Ser Val His Arg Thr Pro Ser Arg Gln Cys 
    450                 455                 460 


<210>  8
<211>  481
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(481)

<400>  8

Met Ala Leu Ser Tyr Arg Val Ser Glu Leu Gln Ser Thr Ile Pro Glu 
1               5                   10                  15      


His Ile Leu Gln Ser Thr Phe Val His Val Ile Ser Ser Asn Trp Ser 
            20                  25                  30          


Gly Leu Gln Thr Glu Ser Ile Pro Glu Glu Met Lys Gln Ile Val Glu 
        35                  40                  45              


Glu Gln Gly Asn Lys Leu His Trp Ala Ala Leu Leu Ile Leu Met Val 
    50                  55                  60                  


Ile Ile Pro Thr Ile Gly Gly Asn Thr Leu Val Ile Leu Ala Val Ser 
65                  70                  75                  80  


Leu Glu Lys Lys Leu Gln Tyr Ala Thr Asn Tyr Phe Leu Met Ser Leu 
                85                  90                  95      


Ala Val Ala Asp Leu Leu Val Gly Leu Phe Val Met Pro Ile Ala Leu 
            100                 105                 110         


Leu Thr Ile Met Phe Glu Ala Met Trp Pro Leu Pro Leu Val Leu Cys 
        115                 120                 125             


Pro Ala Trp Leu Phe Leu Asp Val Leu Phe Ser Thr Ala Ser Ile Met 
    130                 135                 140                 


His Leu Cys Ala Ile Ser Val Asp Arg Tyr Ile Ala Ile Lys Lys Pro 
145                 150                 155                 160 


Ile Gln Ala Asn Gln Tyr Asn Ser Arg Ala Thr Ala Phe Ile Lys Ile 
                165                 170                 175     


Thr Val Val Trp Leu Ile Ser Ile Gly Ile Ala Ile Pro Val Pro Ile 
            180                 185                 190         


Lys Gly Ile Glu Thr Asp Val Asp Asn Pro Asn Asn Ile Thr Cys Val 
        195                 200                 205             


Leu Thr Lys Glu Arg Phe Gly Asp Phe Met Leu Phe Gly Ser Leu Ala 
    210                 215                 220                 


Ala Phe Phe Thr Pro Leu Ala Ile Met Ile Val Thr Tyr Phe Leu Thr 
225                 230                 235                 240 


Ile His Ala Leu Gln Lys Lys Ala Tyr Leu Val Lys Asn Lys Pro Pro 
                245                 250                 255     


Gln Arg Leu Thr Trp Leu Thr Val Ser Thr Val Phe Gln Arg Asp Glu 
            260                 265                 270         


Thr Pro Cys Ser Ser Pro Glu Lys Val Ala Met Leu Asp Gly Ser Arg 
        275                 280                 285             


Lys Asp Lys Ala Leu Pro Asn Ser Gly Asp Glu Thr Leu Met Arg Arg 
    290                 295                 300                 


Thr Ser Thr Ile Gly Lys Lys Ser Val Gln Thr Ile Ser Asn Glu Gln 
305                 310                 315                 320 


Arg Ala Ser Lys Val Leu Gly Ile Val Phe Phe Leu Phe Leu Leu Met 
                325                 330                 335     


Trp Cys Pro Phe Phe Ile Thr Asn Ile Thr Leu Val Leu Cys Asp Ser 
            340                 345                 350         


Cys Asn Gln Thr Thr Leu Gln Met Leu Leu Glu Ile Phe Val Trp Ile 
        355                 360                 365             


Gly Tyr Val Ser Ser Gly Val Asn Pro Leu Val Tyr Thr Leu Phe Asn 
    370                 375                 380                 


Lys Thr Phe Arg Asp Ala Phe Gly Arg Tyr Ile Thr Cys Asn Tyr Arg 
385                 390                 395                 400 


Ala Thr Lys Ser Val Lys Thr Leu Arg Lys Arg Ser Ser Lys Ile Tyr 
                405                 410                 415     


Phe Arg Asn Pro Met Ala Glu Asn Ser Lys Phe Phe Lys Lys His Gly 
            420                 425                 430         


Ile Arg Asn Gly Ile Asn Pro Ala Met Tyr Gln Ser Pro Met Arg Leu 
        435                 440                 445             


Arg Ser Ser Thr Ile Gln Ser Ser Ser Ile Ile Leu Leu Asp Thr Leu 
    450                 455                 460                 


Leu Leu Thr Glu Asn Glu Gly Asp Lys Thr Glu Glu Gln Val Ser Tyr 
465                 470                 475                 480 


Val 
    


