                         SEQUENCE LISTING

<110>  University of Rochester
       Jin, Zheng-Gen
 
<120>  THE cAMP/PKA/HDAC5 PATHWAY AND USES THEROF

<130>  10028-048WO1

<150>  US 61/363,895
<151>  2010-07-13

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Thr Thr Tyr Ala Asp Phe Ile Ala Ser Gly Arg Thr Gly Arg Arg Asn 
1               5                   10                  15      


Ala Ile His Asp 
            20  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys 
1               5                   10                  


<210>  3
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
gctgagcgga gaagcgctcc cctcctgcgt                                        30


<210>  4
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
acgcaggagg ggagcgcttc tccgctcagc                                        30


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
gctgagcgga gaagcgatcc cctcctgcgt                                        30


<210>  6
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
acgcaggagg ggatcgcttc tccgctcagc                                        30


<210>  7
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
cctggagaga cgcagcagtc ccctgctcag ga                                     32


<210>  8
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
tcctgagcag gggactgctg cgtctctcca gg                                     32


<210>  9
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
gctagtccgg aatgtaccca tacgatgttc cagattacgc tatgggcaac gccgccgccg       60

ccaa                                                                    64


<210>  10
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
gccctcgagc aaactcagta aactccttgc ca                                     32


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11
atgggctcct tctccatcac                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
atcttcggta ccggaagctg                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
actgggacga catggaaaag                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
catctccaga gtccagcaca                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
cctcgcaata tcaagggaaa                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
tacaggtgca tcagctccag                                                   20


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
cgatgctggc gctgagta                                                     18


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18
cgttcagctc agggatgacc                                                   20


<210>  19
<211>  1123
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Asn Ser Pro Asn Glu Ser Ala Asp Gly Met Ser Gly Arg Glu Pro 
1               5                   10                  15      


Ser Leu Glu Ile Leu Pro Arg Thr Ser Leu His Ser Ile Pro Val Thr 
            20                  25                  30          


Val Glu Val Lys Pro Val Leu Pro Arg Ala Met Pro Ser Ser Met Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Ser Pro Ser Pro Val Glu Leu Arg Gly Ala Leu 
    50                  55                  60                  


Val Gly Ser Val Asp Pro Thr Leu Arg Glu Gln Gln Leu Gln Gln Glu 
65                  70                  75                  80  


Leu Leu Ala Leu Lys Gln Gln Gln Gln Leu Gln Lys Gln Leu Leu Phe 
                85                  90                  95      


Ala Glu Phe Gln Lys Gln His Asp His Leu Thr Arg Gln His Glu Val 
            100                 105                 110         


Gln Leu Gln Lys His Leu Lys Gln Gln Gln Glu Met Leu Ala Ala Lys 
        115                 120                 125             


Gln Gln Gln Glu Met Leu Ala Ala Lys Arg Gln Gln Glu Leu Glu Gln 
    130                 135                 140                 


Gln Arg Gln Arg Glu Gln Gln Arg Gln Glu Glu Leu Glu Lys Gln Arg 
145                 150                 155                 160 


Leu Glu Gln Gln Leu Leu Ile Leu Arg Asn Lys Glu Lys Ser Lys Glu 
                165                 170                 175     


Ser Ala Ile Ala Ser Thr Glu Val Lys Leu Arg Leu Gln Glu Phe Leu 
            180                 185                 190         


Leu Ser Lys Ser Lys Glu Pro Thr Pro Gly Gly Leu Asn His Ser Leu 
        195                 200                 205             


Pro Gln His Pro Lys Cys Trp Gly Ala His His Ala Ser Leu Asp Gln 
    210                 215                 220                 


Ser Ser Pro Pro Gln Ser Gly Pro Pro Gly Thr Pro Pro Ser Tyr Lys 
225                 230                 235                 240 


Leu Pro Leu Pro Gly Pro Tyr Asp Ser Arg Asp Asp Phe Pro Leu Arg 
                245                 250                 255     


Lys Thr Ala Ser Glu Pro Asn Leu Lys Val Arg Ser Arg Leu Lys Gln 
            260                 265                 270         


Lys Val Ala Glu Arg Arg Ser Ser Pro Leu Leu Arg Arg Lys Asp Gly 
        275                 280                 285             


Thr Val Ile Ser Thr Phe Lys Lys Arg Ala Val Glu Ile Thr Gly Ala 
    290                 295                 300                 


Gly Pro Gly Ala Ser Ser Val Cys Asn Ser Ala Pro Gly Ser Gly Pro 
305                 310                 315                 320 


Ser Ser Pro Asn Ser Ser His Ser Thr Ile Ala Glu Asn Gly Phe Thr 
                325                 330                 335     


Gly Ser Val Pro Asn Ile Pro Thr Glu Met Leu Pro Gln His Arg Ala 
            340                 345                 350         


Leu Pro Leu Asp Ser Ser Pro Asn Gln Phe Ser Leu Tyr Thr Ser Pro 
        355                 360                 365             


Ser Leu Pro Asn Ile Ser Leu Gly Leu Gln Ala Thr Val Thr Val Thr 
    370                 375                 380                 


Asn Ser His Leu Thr Ala Ser Pro Lys Leu Ser Thr Gln Gln Glu Ala 
385                 390                 395                 400 


Glu Arg Gln Ala Leu Gln Ser Leu Arg Gln Gly Gly Thr Leu Thr Gly 
                405                 410                 415     


Lys Phe Met Ser Thr Ser Ser Ile Pro Gly Cys Leu Leu Gly Val Ala 
            420                 425                 430         


Leu Glu Gly Asp Gly Ser Pro His Gly His Ala Ser Leu Leu Gln His 
        435                 440                 445             


Val Leu Leu Leu Glu Gln Ala Arg Gln Gln Ser Thr Leu Ile Ala Val 
    450                 455                 460                 


Pro Leu His Gly Gln Ser Pro Leu Val Thr Gly Glu Arg Val Ala Thr 
465                 470                 475                 480 


Ser Met Arg Thr Val Gly Lys Leu Pro Arg His Arg Pro Leu Ser Arg 
                485                 490                 495     


Thr Gln Ser Ser Pro Leu Pro Gln Ser Pro Gln Ala Leu Gln Gln Leu 
            500                 505                 510         


Val Met Gln Gln Gln His Gln Gln Phe Leu Glu Lys Gln Lys Gln Gln 
        515                 520                 525             


Gln Leu Gln Leu Gly Lys Ile Leu Thr Lys Thr Gly Glu Leu Pro Arg 
    530                 535                 540                 


Gln Pro Thr Thr His Pro Glu Glu Thr Glu Glu Glu Leu Thr Glu Gln 
545                 550                 555                 560 


Gln Glu Val Leu Leu Gly Glu Gly Ala Leu Thr Met Pro Arg Glu Gly 
                565                 570                 575     


Ser Thr Glu Ser Glu Ser Thr Gln Glu Asp Leu Glu Glu Glu Asp Glu 
            580                 585                 590         


Glu Asp Asp Gly Glu Glu Glu Glu Asp Cys Ile Gln Val Lys Asp Glu 
        595                 600                 605             


Glu Gly Glu Ser Gly Ala Glu Glu Gly Pro Asp Leu Glu Glu Pro Gly 
    610                 615                 620                 


Ala Gly Tyr Lys Lys Leu Phe Ser Asp Ala Gln Pro Leu Gln Pro Leu 
625                 630                 635                 640 


Gln Val Tyr Gln Ala Pro Leu Ser Leu Ala Thr Val Pro His Gln Ala 
                645                 650                 655     


Leu Gly Arg Thr Gln Ser Ser Pro Ala Ala Pro Gly Gly Met Lys Ser 
            660                 665                 670         


Pro Pro Asp Gln Pro Val Lys His Leu Phe Thr Thr Gly Val Val Tyr 
        675                 680                 685             


Asp Thr Phe Met Leu Lys His Gln Cys Met Cys Gly Asn Thr His Val 
    690                 695                 700                 


His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln 
705                 710                 715                 720 


Glu Thr Gly Leu Leu Ser Lys Cys Glu Arg Ile Arg Gly Arg Lys Ala 
                725                 730                 735     


Thr Leu Asp Glu Ile Gln Thr Val His Ser Glu Tyr His Thr Leu Leu 
            740                 745                 750         


Tyr Gly Thr Ser Pro Leu Asn Arg Gln Lys Leu Asp Ser Lys Lys Leu 
        755                 760                 765             


Leu Gly Pro Ile Ser Gln Lys Met Tyr Ala Val Leu Pro Cys Gly Gly 
    770                 775                 780                 


Ile Gly Val Asp Ser Asp Thr Val Trp Asn Glu Met His Ser Ser Ser 
785                 790                 795                 800 


Ala Val Arg Met Ala Val Gly Cys Leu Leu Glu Leu Ala Phe Lys Val 
                805                 810                 815     


Ala Ala Gly Glu Leu Lys Asn Gly Phe Ala Ile Ile Arg Pro Pro Gly 
            820                 825                 830         


His His Ala Glu Glu Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser 
        835                 840                 845             


Val Ala Ile Thr Ala Lys Leu Leu Gln Gln Lys Leu Asn Val Gly Lys 
    850                 855                 860                 


Val Leu Ile Val Asp Trp Asp Ile His His Gly Asn Gly Thr Gln Gln 
865                 870                 875                 880 


Ala Phe Tyr Asn Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg Tyr 
                885                 890                 895     


Asp Asn Gly Asn Phe Phe Pro Gly Ser Gly Ala Pro Glu Glu Val Gly 
            900                 905                 910         


Gly Gly Pro Gly Val Gly Tyr Asn Val Asn Val Ala Trp Thr Gly Gly 
        915                 920                 925             


Val Asp Pro Pro Ile Gly Asp Val Glu Tyr Leu Thr Ala Phe Arg Thr 
    930                 935                 940                 


Val Val Met Pro Ile Ala His Glu Phe Ser Pro Asp Val Val Leu Val 
945                 950                 955                 960 


Ser Ala Gly Phe Asp Ala Val Glu Gly His Leu Ser Pro Leu Gly Gly 
                965                 970                 975     


Tyr Ser Val Thr Ala Arg Cys Phe Gly His Leu Thr Arg Gln Leu Met 
            980                 985                 990         


Thr Leu Ala Gly Gly Arg Val Val  Leu Ala Leu Glu Gly  Gly His Asp 
        995                 1000                 1005             


Leu Thr  Ala Ile Cys Asp Ala  Ser Glu Ala Cys Val  Ser Ala Leu 
    1010                 1015                 1020             


Leu Ser  Val Glu Leu Gln Pro  Leu Asp Glu Ala Val  Leu Gln Gln 
    1025                 1030                 1035             


Lys Pro  Asn Ile Asn Ala Val  Ala Thr Leu Glu Lys  Val Ile Glu 
    1040                 1045                 1050             


Ile Gln  Ser Lys His Trp Ser  Cys Val Gln Lys Phe  Ala Ala Gly 
    1055                 1060                 1065             


Leu Gly  Arg Ser Leu Arg Glu  Ala Gln Ala Gly Glu  Thr Glu Glu 
    1070                 1075                 1080             


Ala Glu  Thr Val Ser Ala Met  Ala Leu Leu Ser Val  Gly Ala Glu 
    1085                 1090                 1095             


Gln Ala  Gln Ala Ala Ala Ala  Arg Glu His Ser Pro  Arg Pro Ala 
    1100                 1105                 1110             


Glu Glu  Pro Met Glu Gln Glu  Pro Ala Leu 
    1115                 1120             


<210>  20
<211>  952
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Asp Leu Arg Val Gly Gln Arg Pro Pro Val Glu Pro Pro Pro Glu 
1               5                   10                  15      


Pro Thr Leu Leu Ala Leu Gln Arg Pro Gln Arg Leu His His His Leu 
            20                  25                  30          


Phe Leu Ala Gly Leu Gln Gln Gln Arg Ser Val Glu Pro Met Arg Leu 
        35                  40                  45              


Ser Met Asp Thr Pro Met Pro Glu Leu Gln Val Gly Pro Gln Glu Gln 
    50                  55                  60                  


Glu Leu Arg Gln Leu Leu His Lys Asp Lys Ser Lys Arg Ser Ala Val 
65                  70                  75                  80  


Ala Ser Ser Val Val Lys Gln Lys Leu Ala Glu Val Ile Leu Lys Lys 
                85                  90                  95      


Gln Gln Ala Ala Leu Glu Arg Thr Val His Pro Asn Ser Pro Gly Ile 
            100                 105                 110         


Pro Tyr Arg Thr Leu Glu Pro Leu Glu Thr Glu Gly Ala Thr Arg Ser 
        115                 120                 125             


Met Leu Ser Ser Phe Leu Pro Pro Val Pro Ser Leu Pro Ser Asp Pro 
    130                 135                 140                 


Pro Glu His Phe Pro Leu Arg Lys Thr Val Ser Glu Pro Asn Leu Lys 
145                 150                 155                 160 


Leu Arg Tyr Lys Pro Lys Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu 
                165                 170                 175     


Leu Arg Lys Glu Ser Ala Pro Pro Ser Leu Arg Arg Arg Pro Ala Glu 
            180                 185                 190         


Thr Leu Gly Asp Ser Ser Pro Ser Ser Ser Ser Thr Pro Ala Ser Gly 
        195                 200                 205             


Cys Ser Ser Pro Asn Asp Ser Glu His Gly Pro Asn Pro Ile Leu Gly 
    210                 215                 220                 


Ser Glu Ala Leu Leu Gly Gln Arg Leu Arg Leu Gln Glu Thr Ser Val 
225                 230                 235                 240 


Ala Pro Phe Ala Leu Pro Thr Val Ser Leu Leu Pro Ala Ile Thr Leu 
                245                 250                 255     


Gly Leu Pro Ala Pro Ala Arg Ala Asp Ser Asp Arg Arg Thr His Pro 
            260                 265                 270         


Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr Pro Leu 
        275                 280                 285             


Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu Pro Ser 
    290                 295                 300                 


Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His Ala Pro 
305                 310                 315                 320 


Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe Ala Gln 
                325                 330                 335     


Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro 
            340                 345                 350         


Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro 
        355                 360                 365             


Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His 
    370                 375                 380                 


Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu 
385                 390                 395                 400 


Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro 
                405                 410                 415     


Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly His Gly 
            420                 425                 430         


Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro Gln Val 
        435                 440                 445             


Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg Gly Ser 
    450                 455                 460                 


Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His Arg Pro 
465                 470                 475                 480 


Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu Ser Ala 
                485                 490                 495     


Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu Thr Pro 
            500                 505                 510         


Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser Val Met 
        515                 520                 525             


Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro Glu His 
    530                 535                 540                 


Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg Gly Leu 
545                 550                 555                 560 


Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu Glu Glu 
                565                 570                 575     


Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly Thr Asn 
            580                 585                 590         


Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly Leu Leu 
        595                 600                 605             


Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly Val Asp 
    610                 615                 620                 


Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala Arg Trp 
625                 630                 635                 640 


Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser Arg Glu 
                645                 650                 655     


Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Asp 
            660                 665                 670         


His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala 
        675                 680                 685             


Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val 
    690                 695                 700                 


Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln 
705                 710                 715                 720 


Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn 
                725                 730                 735     


Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly 
            740                 745                 750         


Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro 
        755                 760                 765             


Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro 
    770                 775                 780                 


Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe 
785                 790                 795                 800 


Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His Val Ser 
                805                 810                 815     


Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly 
            820                 825                 830         


Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile 
        835                 840                 845             


Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val 
    850                 855                 860                 


Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala 
865                 870                 875                 880 


Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr Trp Gly 
                885                 890                 895     


Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val 
            900                 905                 910         


Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser 
        915                 920                 925             


Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val 
    930                 935                 940                 


Glu Glu Glu Glu Pro Met Asn Leu 
945                 950


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu Leu Arg Lys Glu 
1               5                   10                  
         


