                         SEQUENCE LISTING

<110>  Low, Susan
       Peters, Robert
 
<120>  SYSTEMS FOR FACTOR VIII PROCESSING AND METHODS THEREOF

<130>  2159.278PC01

<140>  To be assigned
<141>  Herewith

<150>  61/363,184
<151>  2010-07-09

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  4314
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-domain deleted Factor VIII (S743/Q1638)

<400>  1
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg cgtccttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctctc aaaacccacc agtcttgaaa cgccatcaac gggaaataac tcgtactact     2280

cttcagtcag atcaagagga aattgactat gatgatacca tatcagttga aatgaagaag     2340

gaagattttg acatttatga tgaggatgaa aatcagagcc cccgcagctt tcaaaagaaa     2400

acacgacact attttattgc tgcagtggag aggctctggg attatgggat gagtagctcc     2460

ccacatgttc taagaaacag ggctcagagt ggcagtgtcc ctcagttcaa gaaagttgtt     2520

ttccaggaat ttactgatgg ctcctttact cagcccttat accgtggaga actaaatgaa     2580

catttgggac tcctggggcc atatataaga gcagaagttg aagataatat catggtaact     2640

ttcagaaatc aggcctctcg tccctattcc ttctattcta gccttatttc ttatgaggaa     2700

gatcagaggc aaggagcaga acctagaaaa aactttgtca agcctaatga aaccaaaact     2760

tacttttgga aagtgcaaca tcatatggca cccactaaag atgagtttga ctgcaaagcc     2820

tgggcttatt tctctgatgt tgacctggaa aaagatgtgc actcaggcct gattggaccc     2880

cttctggtct gccacactaa cacactgaac cctgctcatg ggagacaagt gacagtacag     2940

gaatttgctc tgtttttcac catctttgat gagaccaaaa gctggtactt cactgaaaat     3000

atggaaagaa actgcagggc tccctgcaat atccagatgg aagatcccac ttttaaagag     3060

aattatcgct tccatgcaat caatggctac ataatggata cactacctgg cttagtaatg     3120

gctcaggatc aaaggattcg atggtatctg ctcagcatgg gcagcaatga aaacatccat     3180

tctattcatt tcagtggaca tgtgttcact gtacgaaaaa aagaggagta taaaatggca     3240

ctgtacaatc tctatccagg tgtttttgag acagtggaaa tgttaccatc caaagctgga     3300

atttggcggg tggaatgcct tattggcgag catctacatg ctgggatgag cacacttttt     3360

ctggtgtaca gcaataagtg tcagactccc ctgggaatgg cttctggaca cattagagat     3420

tttcagatta cagcttcagg acaatatgga cagtgggccc caaagctggc cagacttcat     3480

tattccggat caatcaatgc ctggagcacc aaggagccct tttcttggat caaggtggat     3540

ctgttggcac caatgattat tcacggcatc aagacccagg gtgcccgtca gaagttctcc     3600

agcctctaca tctctcagtt tatcatcatg tatagtcttg atgggaagaa gtggcagact     3660

tatcgaggaa attccactgg aaccttaatg gtcttctttg gcaatgtgga ttcatctggg     3720

ataaaacaca atatttttaa ccctccaatt attgctcgat acatccgttt gcacccaact     3780

cattatagca ttcgcagcac tcttcgcatg gagttgatgg gctgtgattt aaatagttgc     3840

agcatgccat tgggaatgga gagtaaagca atatcagatg cacagattac tgcttcatcc     3900

tactttacca atatgtttgc cacctggtct ccttcaaaag ctcgacttca cctccaaggg     3960

aggagtaatg cctggagacc tcaggtgaat aatccaaaag agtggctgca agtggacttc     4020

cagaagacaa tgaaagtcac aggagtaact actcagggag taaaatctct gcttaccagc     4080

atgtatgtga aggagttcct catctccagc agtcaagatg gccatcagtg gactctcttt     4140

tttcagaatg gcaaagtaaa ggtttttcag ggaaatcaag actccttcac acctgtggtg     4200

aactctctag acccaccgtt actgactcgc taccttcgaa ttcaccccca gagttgggtg     4260

caccagattg ccctgaggat ggaggttctg ggctgcgagg cacaggacct ctac           4314


<210>  2
<211>  1438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-domain deleted Factor VIII (S743/Q1638)

<400>  2

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu Lys Arg His 
            740                 745                 750         


Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile 
        755                 760                 765             


Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu Asp Phe Asp 
    770                 775                 780                 


Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe Gln Lys Lys 
785                 790                 795                 800 


Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly 
                805                 810                 815     


Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln Ser Gly Ser 
            820                 825                 830         


Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser 
        835                 840                 845             


Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu 
    850                 855                 860                 


Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr 
865                 870                 875                 880 


Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile 
                885                 890                 895     


Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg Lys Asn Phe 
            900                 905                 910         


Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val Gln His His 
        915                 920                 925             


Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe 
    930                 935                 940                 


Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu Ile Gly Pro 
945                 950                 955                 960 


Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln 
                965                 970                 975     


Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr Ile Phe Asp Glu Thr 
            980                 985                 990         


Lys Ser Trp Tyr Phe Thr Glu Asn  Met Glu Arg Asn Cys  Arg Ala Pro 
        995                 1000                 1005             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe Lys Glu  Asn Tyr Arg 
    1010                 1015                 1020             


Phe His  Ala Ile Asn Gly Tyr  Ile Met Asp Thr Leu  Pro Gly Leu 
    1025                 1030                 1035             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1040                 1045                 1050             


Gly Ser  Asn Glu Asn Ile His  Ser Ile His Phe Ser  Gly His Val 
    1055                 1060                 1065             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Leu Tyr Asn 
    1070                 1075                 1080             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Lys 
    1085                 1090                 1095             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu His 
    1100                 1105                 1110             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Asn  Lys Cys Gln 
    1115                 1120                 1125             


Thr Pro  Leu Gly Met Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile 
    1130                 1135                 1140             


Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg 
    1145                 1150                 1155             


Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1160                 1165                 1170             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala Pro Met  Ile Ile His 
    1175                 1180                 1185             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1190                 1195                 1200             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1205                 1210                 1215             


Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1220                 1225                 1230             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro 
    1235                 1240                 1245             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser 
    1250                 1255                 1260             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1265                 1270                 1275             


Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp 
    1280                 1285                 1290             


Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1295                 1300                 1305             


Trp Ser  Pro Ser Lys Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn 
    1310                 1315                 1320             


Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val 
    1325                 1330                 1335             


Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly Val Thr  Thr Gln Gly 
    1340                 1345                 1350             


Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile 
    1355                 1360                 1365             


Ser Ser  Ser Gln Asp Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn 
    1370                 1375                 1380             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro 
    1385                 1390                 1395             


Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1400                 1405                 1410             


Ile His  Pro Gln Ser Trp Val  His Gln Ile Ala Leu  Arg Met Glu 
    1415                 1420                 1425             


Val Leu  Gly Cys Glu Ala Gln  Asp Leu Tyr 
    1430                 1435             


<210>  3
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fc fragment

<400>  3
atggagacag acacactcct gctatgggta ctgctgctct gggttccagg ttccactggt       60

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggagg accgtcagtc      120

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      180

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      240

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      300

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      360

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      420

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgcgatga gctgaccaag      480

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      540

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc      600

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      660

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      720

ctctccctgt ctccgggtaa a                                                741


<210>  4
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc fragment

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  5
<211>  6996
<212>  DNA
<213>  Homo sapiens

<400>  5
gccaccagaa gatactacct gggtgcagtg gaactgtcat gggactatat gcaaagtgat       60

ctcggtgagc tgcctgtgga cgcaagattt cctcctagag tgccaaaatc ttttccattc      120

aacacctcag tcgtgtacaa aaagactctg tttgtagaat tcacggatca ccttttcaac      180

atcgctaagc caaggccacc ctggatgggt ctgctaggtc ctaccatcca ggctgaggtt      240

tatgatacag tggtcattac acttaagaac atggcttccc atcctgtcag tcttcatgct      300

gttggtgtat cctactggaa agcttctgag ggagctgaat atgatgatca gaccagtcaa      360

agggagaaag aagatgataa agtcttccct ggtggaagcc atacatatgt ctggcaggtc      420

ctgaaagaga atggtccaat ggcctctgac ccactgtgcc ttacctactc atatctttct      480

catgtggacc tggtaaaaga cttgaattca ggcctcattg gagccctact agtatgtaga      540

gaagggagtc tggccaagga aaagacacag accttgcaca aatttatact actttttgct      600

gtatttgatg aagggaaaag ttggcactca gaaacaaaga actccttgat gcaggatagg      660

gatgctgcat ctgctcgggc ctggcctaaa atgcacacag tcaatggtta tgtaaacagg      720

tctctgccag gtctgattgg atgccacagg aaatcagtct attggcatgt gattggaatg      780

ggcaccactc ctgaagtgca ctcaatattc ctcgaaggtc acacatttct tgtgaggaac      840

catcgccagg cgtccttgga aatctcgcca ataactttcc ttactgctca aacactcttg      900

atggaccttg gacagtttct actgttttgt catatctctt cccaccaaca tgatggcatg      960

gaagcttatg tcaaagtaga cagctgtcca gaggaacccc aactacgaat gaaaaataat     1020

gaagaagcgg aagactatga tgatgatctt actgattctg aaatggatgt ggtcaggttt     1080

gatgatgaca actctccttc ctttatccaa attcgctcag ttgccaagaa gcatcctaaa     1140

acttgggtac attacattgc tgctgaagag gaggactggg actatgctcc cttagtcctc     1200

gcccccgatg acagaagtta taaaagtcaa tatttgaaca atggccctca gcggattggt     1260

aggaagtaca aaaaagtccg atttatggca tacacagatg aaacctttaa gactcgtgaa     1320

gctattcagc atgaatcagg aatcttggga cctttacttt atggggaagt tggagacaca     1380

ctgttgatta tatttaagaa tcaagcaagc agaccatata acatctaccc tcacggaatc     1440

actgatgtcc gtcctttgta ttcaaggaga ttaccaaaag gtgtaaaaca tttgaaggat     1500

tttccaattc tgccaggaga aatattcaaa tataaatgga cagtgactgt agaagatggg     1560

ccaactaaat cagatcctcg gtgcctgacc cgctattact ctagtttcgt taatatggag     1620

agagatctag cttcaggact cattggccct ctcctcatct gctacaaaga atctgtagat     1680

caaagaggaa accagataat gtcagacaag aggaatgtca tcctgttttc tgtatttgat     1740

gagaaccgaa gctggtacct cacagagaat atacaacgct ttctccccaa tccagctgga     1800

gtgcagcttg aggatccaga gttccaagcc tccaacatca tgcacagcat caatggctat     1860

gtttttgata gtttgcagtt gtcagtttgt ttgcatgagg tggcatactg gtacattcta     1920

agcattggag cacagactga cttcctttct gtcttcttct ctggatatac cttcaaacac     1980

aaaatggtct atgaagacac actcacccta ttcccattct caggagaaac tgtcttcatg     2040

tcgatggaaa acccaggtct atggattctg gggtgccaca actcagactt tcggaacaga     2100

ggcatgaccg ccttactgaa ggtttctagt tgtgacaaga acactggtga ttattacgag     2160

gacagttatg aagatatttc agcatacttg ctgagtaaaa acaatgccat tgaaccaaga     2220

agcttctccc agaattcaag acaccctagc actaggcaaa agcaatttaa tgccaccaca     2280

attccagaaa atgacataga gaagactgac ccttggtttg cacacagaac acctatgcct     2340

aaaatacaaa atgtctcctc tagtgatttg ttgatgctct tgcgacagag tcctactcca     2400

catgggctat ccttatctga tctccaagaa gccaaatatg agactttttc tgatgatcca     2460

tcacctggag caatagacag taataacagc ctgtctgaaa tgacacactt caggccacag     2520

ctccatcaca gtggggacat ggtatttacc cctgagtcag gcctccaatt aagattaaat     2580

gagaaactgg ggacaactgc agcaacagag ttgaagaaac ttgatttcaa agtttctagt     2640

acatcaaata atctgatttc aacaattcca tcagacaatt tggcagcagg tactgataat     2700

acaagttcct taggaccccc aagtatgcca gttcattatg atagtcaatt agataccact     2760

ctatttggca aaaagtcatc tccccttact gagtctggtg gacctctgag cttgagtgaa     2820

gaaaataatg attcaaagtt gttagaatca ggtttaatga atagccaaga aagttcatgg     2880

ggaaaaaatg tatcgtcaac agagagtggt aggttattta aagggaaaag agctcatgga     2940

cctgctttgt tgactaaaga taatgcctta ttcaaagtta gcatctcttt gttaaagaca     3000

aacaaaactt ccaataattc agcaactaat agaaagactc acattgatgg cccatcatta     3060

ttaattgaga atagtccatc agtctggcaa aatatattag aaagtgacac tgagtttaaa     3120

aaagtgacac ctttgattca tgacagaatg cttatggaca aaaatgctac agctttgagg     3180

ctaaatcata tgtcaaataa aactacttca tcaaaaaaca tggaaatggt ccaacagaaa     3240

aaagagggcc ccattccacc agatgcacaa aatccagata tgtcgttctt taagatgcta     3300

ttcttgccag aatcagcaag gtggatacaa aggactcatg gaaagaactc tctgaactct     3360

gggcaaggcc ccagtccaaa gcaattagta tccttaggac cagaaaaatc tgtggaaggt     3420

cagaatttct tgtctgagaa aaacaaagtg gtagtaggaa agggtgaatt tacaaaggac     3480

gtaggactca aagagatggt ttttccaagc agcagaaacc tatttcttac taacttggat     3540

aatttacatg aaaataatac acacaatcaa gaaaaaaaaa ttcaggaaga aatagaaaag     3600

aaggaaacat taatccaaga gaatgtagtt ttgcctcaga tacatacagt gactggcact     3660

aagaatttca tgaagaacct tttcttactg agcactaggc aaaatgtaga aggttcatat     3720

gacggggcat atgctccagt acttcaagat tttaggtcat taaatgattc aacaaataga     3780

acaaagaaac acacagctca tttctcaaaa aaaggggagg aagaaaactt ggaaggcttg     3840

ggaaatcaaa ccaagcaaat tgtagagaaa tatgcatgca ccacaaggat atctcctaat     3900

acaagccagc agaattttgt cacgcaacgt agtaagagag ctttgaaaca attcagactc     3960

ccactagaag aaacagaact tgaaaaaagg ataattgtgg atgacacctc aacccagtgg     4020

tccaaaaaca tgaaacattt gaccccgagc accctcacac agatagacta caatgagaag     4080

gagaaagggg ccattactca gtctccctta tcagattgcc ttacgaggag tcatagcatc     4140

cctcaagcaa atagatctcc attacccatt gcaaaggtat catcatttcc atctattaga     4200

cctatatatc tgaccagggt cctattccaa gacaactctt ctcatcttcc agcagcatct     4260

tatagaaaga aagattctgg ggtccaagaa agcagtcatt tcttacaagg agccaaaaaa     4320

aataaccttt ctttagccat tctaaccttg gagatgactg gtgatcaaag agaggttggc     4380

tccctgggga caagtgccac aaattcagtc acatacaaga aagttgagaa cactgttctc     4440

ccgaaaccag acttgcccaa aacatctggc aaagttgaat tgcttccaaa agttcacatt     4500

tatcagaagg acctattccc tacggaaact agcaatgggt ctcctggcca tctggatctc     4560

gtggaaggga gccttcttca gggaacagag ggagcgatta agtggaatga agcaaacaga     4620

cctggaaaag ttccctttct gagagtagca acagaaagct ctgcaaagac tccctccaag     4680

ctattggatc ctcttgcttg ggataaccac tatggtactc agataccaaa agaagagtgg     4740

aaatcccaag agaagtcacc agaaaaaaca gcttttaaga aaaaggatac cattttgtcc     4800

ctgaacgctt gtgaaagcaa tcatgcaata gcagcaataa atgagggaca aaataagccc     4860

gaaatagaag tcacctgggc aaagcaaggt aggactgaaa ggctgtgctc tcaaaaccca     4920

ccagtcttga aacgccatca acgggaaata actcgtacta ctcttcagtc agatcaagag     4980

gaaattgact atgatgatac catatcagtt gaaatgaaga aggaagattt tgacatttat     5040

gatgaggatg aaaatcagag cccccgcagc tttcaaaaga aaacacgaca ctattttatt     5100

gctgcagtgg agaggctctg ggattatggg atgagtagct ccccacatgt tctaagaaac     5160

agggctcaga gtggcagtgt ccctcagttc aagaaagttg ttttccagga atttactgat     5220

ggctccttta ctcagccctt ataccgtgga gaactaaatg aacatttggg actcctgggg     5280

ccatatataa gagcagaagt tgaagataat atcatggtaa ctttcagaaa tcaggcctct     5340

cgtccctatt ccttctattc tagccttatt tcttatgagg aagatcagag gcaaggagca     5400

gaacctagaa aaaactttgt caagcctaat gaaaccaaaa cttacttttg gaaagtgcaa     5460

catcatatgg cacccactaa agatgagttt gactgcaaag cctgggctta tttctctgat     5520

gttgacctgg aaaaagatgt gcactcaggc ctgattggac cccttctggt ctgccacact     5580

aacacactga accctgctca tgggagacaa gtgacagtac aggaatttgc tctgtttttc     5640

accatctttg atgagaccaa aagctggtac ttcactgaaa atatggaaag aaactgcagg     5700

gctccctgca atatccagat ggaagatccc acttttaaag agaattatcg cttccatgca     5760

atcaatggct acataatgga tacactacct ggcttagtaa tggctcagga tcaaaggatt     5820

cgatggtatc tgctcagcat gggcagcaat gaaaacatcc attctattca tttcagtgga     5880

catgtgttca ctgtacgaaa aaaagaggag tataaaatgg cactgtacaa tctctatcca     5940

ggtgtttttg agacagtgga aatgttacca tccaaagctg gaatttggcg ggtggaatgc     6000

cttattggcg agcatctaca tgctgggatg agcacacttt ttctggtgta cagcaataag     6060

tgtcagactc ccctgggaat ggcttctgga cacattagag attttcagat tacagcttca     6120

ggacaatatg gacagtgggc cccaaagctg gccagacttc attattccgg atcaatcaat     6180

gcctggagca ccaaggagcc cttttcttgg atcaaggtgg atctgttggc accaatgatt     6240

attcacggca tcaagaccca gggtgcccgt cagaagttct ccagcctcta catctctcag     6300

tttatcatca tgtatagtct tgatgggaag aagtggcaga cttatcgagg aaattccact     6360

ggaaccttaa tggtcttctt tggcaatgtg gattcatctg ggataaaaca caatattttt     6420

aaccctccaa ttattgctcg atacatccgt ttgcacccaa ctcattatag cattcgcagc     6480

actcttcgca tggagttgat gggctgtgat ttaaatagtt gcagcatgcc attgggaatg     6540

gagagtaaag caatatcaga tgcacagatt actgcttcat cctactttac caatatgttt     6600

gccacctggt ctccttcaaa agctcgactt cacctccaag ggaggagtaa tgcctggaga     6660

cctcaggtga ataatccaaa agagtggctg caagtggact tccagaagac aatgaaagtc     6720

acaggagtaa ctactcaggg agtaaaatct ctgcttacca gcatgtatgt gaaggagttc     6780

ctcatctcca gcagtcaaga tggccatcag tggactctct tttttcagaa tggcaaagta     6840

aaggtttttc agggaaatca agactccttc acacctgtgg tgaactctct agacccaccg     6900

ttactgactc gctaccttcg aattcacccc cagagttggg tgcaccagat tgccctgagg     6960

atggaggttc tgggctgcga ggcacaggac ctctac                               6996


<210>  6
<211>  2332
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg Phe Pro Pro 
            20                  25                  30          


Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val Tyr Lys Lys 
        35                  40                  45              


Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys Pro 
    50                  55                  60                  


Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu Val 
65                  70                  75                  80  


Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro Val 
                85                  90                  95      


Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly Ala 
            100                 105                 110         


Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys Val 
        115                 120                 125             


Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu Asn 
    130                 135                 140                 


Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser Tyr Leu Ser 
145                 150                 155                 160 


His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala Leu 
                165                 170                 175     


Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr Gln Thr Leu 
            180                 185                 190         


His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser Trp 
        195                 200                 205             


His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp Ala Ala Ser 
    210                 215                 220                 


Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn Arg 
225                 230                 235                 240 


Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp His 
                245                 250                 255     


Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu 
            260                 265                 270         


Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile 
        275                 280                 285             


Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu Gly 
    290                 295                 300                 


Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met 
305                 310                 315                 320 


Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg 
                325                 330                 335     


Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp Leu Thr Asp 
            340                 345                 350         


Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser Phe 
        355                 360                 365             


Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His 
    370                 375                 380                 


Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu Val Leu 
385                 390                 395                 400 


Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro 
                405                 410                 415     


Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr 
            420                 425                 430         


Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser Gly Ile 
        435                 440                 445             


Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile 
    450                 455                 460                 


Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile 
465                 470                 475                 480 


Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly Val Lys 
                485                 490                 495     


His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys 
            500                 505                 510         


Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys 
        515                 520                 525             


Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp Leu Ala 
    530                 535                 540                 


Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp 
545                 550                 555                 560 


Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile Leu Phe 
                565                 570                 575     


Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Ile Gln 
            580                 585                 590         


Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro Glu Phe 
        595                 600                 605             


Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser 
    610                 615                 620                 


Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu 
625                 630                 635                 640 


Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr 
                645                 650                 655     


Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro 
            660                 665                 670         


Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp 
        675                 680                 685             


Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala 
    690                 695                 700                 


Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr Tyr Glu 
705                 710                 715                 720 


Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn Asn Ala 
                725                 730                 735     


Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg 
            740                 745                 750         


Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys 
        755                 760                 765             


Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys Ile Gln Asn 
    770                 775                 780                 


Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser Pro Thr Pro 
785                 790                 795                 800 


His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr Glu Thr Phe 
                805                 810                 815     


Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn Ser Leu Ser 
            820                 825                 830         


Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly Asp Met Val 
        835                 840                 845             


Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu Lys Leu Gly 
    850                 855                 860                 


Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys Val Ser Ser 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn Leu Ala Ala 
                885                 890                 895     


Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met Pro Val His 
            900                 905                 910         


Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys Ser Ser Pro 
        915                 920                 925             


Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu Asn Asn Asp 
    930                 935                 940                 


Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu Ser Ser Trp 
945                 950                 955                 960 


Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe Lys Gly Lys 
                965                 970                 975     


Arg Ala His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys 
            980                 985                 990         


Val Ser Ile Ser Leu Leu Lys Thr  Asn Lys Thr Ser Asn  Asn Ser Ala 
        995                 1000                 1005             


Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro Ser Leu  Leu Ile Glu 
    1010                 1015                 1020             


Asn Ser  Pro Ser Val Trp Gln  Asn Ile Leu Glu Ser  Asp Thr Glu 
    1025                 1030                 1035             


Phe Lys  Lys Val Thr Pro Leu  Ile His Asp Arg Met  Leu Met Asp 
    1040                 1045                 1050             


Lys Asn  Ala Thr Ala Leu Arg  Leu Asn His Met Ser  Asn Lys Thr 
    1055                 1060                 1065             


Thr Ser  Ser Lys Asn Met Glu  Met Val Gln Gln Lys  Lys Glu Gly 
    1070                 1075                 1080             


Pro Ile  Pro Pro Asp Ala Gln  Asn Pro Asp Met Ser  Phe Phe Lys 
    1085                 1090                 1095             


Met Leu  Phe Leu Pro Glu Ser  Ala Arg Trp Ile Gln  Arg Thr His 
    1100                 1105                 1110             


Gly Lys  Asn Ser Leu Asn Ser  Gly Gln Gly Pro Ser  Pro Lys Gln 
    1115                 1120                 1125             


Leu Val  Ser Leu Gly Pro Glu  Lys Ser Val Glu Gly  Gln Asn Phe 
    1130                 1135                 1140             


Leu Ser  Glu Lys Asn Lys Val  Val Val Gly Lys Gly  Glu Phe Thr 
    1145                 1150                 1155             


Lys Asp  Val Gly Leu Lys Glu  Met Val Phe Pro Ser  Ser Arg Asn 
    1160                 1165                 1170             


Leu Phe  Leu Thr Asn Leu Asp  Asn Leu His Glu Asn  Asn Thr His 
    1175                 1180                 1185             


Asn Gln  Glu Lys Lys Ile Gln  Glu Glu Ile Glu Lys  Lys Glu Thr 
    1190                 1195                 1200             


Leu Ile  Gln Glu Asn Val Val  Leu Pro Gln Ile His  Thr Val Thr 
    1205                 1210                 1215             


Gly Thr  Lys Asn Phe Met Lys  Asn Leu Phe Leu Leu  Ser Thr Arg 
    1220                 1225                 1230             


Gln Asn  Val Glu Gly Ser Tyr  Asp Gly Ala Tyr Ala  Pro Val Leu 
    1235                 1240                 1245             


Gln Asp  Phe Arg Ser Leu Asn  Asp Ser Thr Asn Arg  Thr Lys Lys 
    1250                 1255                 1260             


His Thr  Ala His Phe Ser Lys  Lys Gly Glu Glu Glu  Asn Leu Glu 
    1265                 1270                 1275             


Gly Leu  Gly Asn Gln Thr Lys  Gln Ile Val Glu Lys  Tyr Ala Cys 
    1280                 1285                 1290             


Thr Thr  Arg Ile Ser Pro Asn  Thr Ser Gln Gln Asn  Phe Val Thr 
    1295                 1300                 1305             


Gln Arg  Ser Lys Arg Ala Leu  Lys Gln Phe Arg Leu  Pro Leu Glu 
    1310                 1315                 1320             


Glu Thr  Glu Leu Glu Lys Arg  Ile Ile Val Asp Asp  Thr Ser Thr 
    1325                 1330                 1335             


Gln Trp  Ser Lys Asn Met Lys  His Leu Thr Pro Ser  Thr Leu Thr 
    1340                 1345                 1350             


Gln Ile  Asp Tyr Asn Glu Lys  Glu Lys Gly Ala Ile  Thr Gln Ser 
    1355                 1360                 1365             


Pro Leu  Ser Asp Cys Leu Thr  Arg Ser His Ser Ile  Pro Gln Ala 
    1370                 1375                 1380             


Asn Arg  Ser Pro Leu Pro Ile  Ala Lys Val Ser Ser  Phe Pro Ser 
    1385                 1390                 1395             


Ile Arg  Pro Ile Tyr Leu Thr  Arg Val Leu Phe Gln  Asp Asn Ser 
    1400                 1405                 1410             


Ser His  Leu Pro Ala Ala Ser  Tyr Arg Lys Lys Asp  Ser Gly Val 
    1415                 1420                 1425             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Lys  Asn Asn Leu 
    1430                 1435                 1440             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Thr Gly Asp  Gln Arg Glu 
    1445                 1450                 1455             


Val Gly  Ser Leu Gly Thr Ser  Ala Thr Asn Ser Val  Thr Tyr Lys 
    1460                 1465                 1470             


Lys Val  Glu Asn Thr Val Leu  Pro Lys Pro Asp Leu  Pro Lys Thr 
    1475                 1480                 1485             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Ile  Tyr Gln Lys 
    1490                 1495                 1500             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1505                 1510                 1515             


Asp Leu  Val Glu Gly Ser Leu  Leu Gln Gly Thr Glu  Gly Ala Ile 
    1520                 1525                 1530             


Lys Trp  Asn Glu Ala Asn Arg  Pro Gly Lys Val Pro  Phe Leu Arg 
    1535                 1540                 1545             


Val Ala  Thr Glu Ser Ser Ala  Lys Thr Pro Ser Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Leu  Ala Trp Asp Asn His  Tyr Gly Thr Gln Ile  Pro Lys Glu 
    1565                 1570                 1575             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Glu Lys Thr  Ala Phe Lys 
    1580                 1585                 1590             


Lys Lys  Asp Thr Ile Leu Ser  Leu Asn Ala Cys Glu  Ser Asn His 
    1595                 1600                 1605             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asn Lys Pro  Glu Ile Glu 
    1610                 1615                 1620             


Val Thr  Trp Ala Lys Gln Gly  Arg Thr Glu Arg Leu  Cys Ser Gln 
    1625                 1630                 1635             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Arg Thr 
    1640                 1645                 1650             


Thr Leu  Gln Ser Asp Gln Glu  Glu Ile Asp Tyr Asp  Asp Thr Ile 
    1655                 1660                 1665             


Ser Val  Glu Met Lys Lys Glu  Asp Phe Asp Ile Tyr  Asp Glu Asp 
    1670                 1675                 1680             


Glu Asn  Gln Ser Pro Arg Ser  Phe Gln Lys Lys Thr  Arg His Tyr 
    1685                 1690                 1695             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Ser 
    1700                 1705                 1710             


Ser Pro  His Val Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1715                 1720                 1725             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1730                 1735                 1740             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1745                 1750                 1755             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1760                 1765                 1770             


Thr Phe  Arg Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1775                 1780                 1785             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1790                 1795                 1800             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1805                 1810                 1815             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1820                 1825                 1830             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Val His 
    1835                 1840                 1845             


Ser Gly  Leu Ile Gly Pro Leu  Leu Val Cys His Thr  Asn Thr Leu 
    1850                 1855                 1860             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1865                 1870                 1875             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1880                 1885                 1890             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1895                 1900                 1905             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1910                 1915                 1920             


Tyr Ile  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1925                 1930                 1935             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1940                 1945                 1950             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1955                 1960                 1965             


Glu Glu  Tyr Lys Met Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    1970                 1975                 1980             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    1985                 1990                 1995             


Glu Cys  Leu Ile Gly Glu His  Leu His Ala Gly Met  Ser Thr Leu 
    2000                 2005                 2010             


Phe Leu  Val Tyr Ser Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala 
    2015                 2020                 2025             


Ser Gly  His Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2030                 2035                 2040             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2045                 2050                 2055             


Ile Asn  Ala Trp Ser Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val 
    2060                 2065                 2070             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2075                 2080                 2085             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2090                 2095                 2100             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn 
    2105                 2110                 2115             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2120                 2125                 2130             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2135                 2140                 2145             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2150                 2155                 2160             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2165                 2170                 2175             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2180                 2185                 2190             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala 
    2195                 2200                 2205             


Arg Leu  His Leu Gln Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val 
    2210                 2215                 2220             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2225                 2230                 2235             


Lys Val  Thr Gly Val Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2240                 2245                 2250             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2255                 2260                 2265             


His Gln  Trp Thr Leu Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe 
    2270                 2275                 2280             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2285                 2290                 2295             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2300                 2305                 2310             


Val His  Gln Ile Ala Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala 
    2315                 2320                 2325             


Gln Asp  Leu Tyr 
    2330         


<210>  7
<211>  2262
<212>  DNA
<213>  Homo sapiens

<400>  7
atggagcgaa gagcctggag tctgcagtgc actgctttcg tcctcttttg cgcttggtgt       60

gcactgaaca gtgcaaaagc gaaaaggcaa tttgtcaatg aatgggcagc ggagatcccc      120

gggggcccgg aagcagcctc ggccatcgcc gaggagctgg gctatgacct tttgggtcag      180

attggttcac ttgaaaatca ctacttattc aaacataaaa accaccccag aaggtctcga      240

aggagtgcct ttcatatcac taagagatta tctgatgatg atcgtgtgat atgggctgaa      300

caacagtatg aaaaagaaag aagtaaacgt tcagctctaa gggactcagc actaaatctc      360

ttcaatgatc ccatgtggaa tcagcaatgg tacttgcaag ataccaggat gacggcagcc      420

ctgcccaagc tggaccttca tgtgatacct gtttggcaaa aaggcattac gggcaaagga      480

gttgttatca ccgtactgga tgatggtttg gagtggaatc acacggacat ttatgccaac      540

tatgatccag aggctagcta tgattttaat gataatgacc atgatccatt tccccgatat      600

gatcccacaa acgagaacaa acacgggacc agatgtgcag gagaaattgc catgcaagca      660

aataatcaca aatgcggggt tggagttgca tacaattcca aagttggagg cataagaatg      720

ctggatggca ttgtgacgga tgctattgag gccagttcaa ttggattcaa tcctggacac      780

gtggatattt acagtgcaag ctggggccct aatgatgatg ggaaaactgt ggaggggcct      840

ggccggctag cccagaaggc ttttgaatat ggtgtcaaac aggggagaca ggggaagggg      900

tccatcttcg tctgggcttc gggaaacggg gggcgtcagg gagataattg tgactgtgat      960

ggctacacag acagcatcta caccatctcc atcagcagtg cctcccagca aggcctatcc     1020

ccctggtacg ctgagaagtg ctcctccaca ctggccacct cttacagcag cggagattac     1080

accgaccaga gaatcacgag cgctgacctg cacaatgact gcacggagac gcacacaggc     1140

acctcggcct ctgcacctct ggctgctggc atcttcgctc tggccctgga agcaaaccca     1200

aatctcacct ggcgagatat gcagcacctg gttgtctgga cctctgagta tgacccgctg     1260

gccaataacc ctggatggaa aaagaatgga gcaggcttga tggtgaatag tcgatttgga     1320

tttggcttgc taaatgccaa agctctggtg gatttagctg accccaggac ctggaggagc     1380

gtgcctgaga agaaagagtg tgttgtaaag gacaatgact ttgagcccag agccctgaaa     1440

gctaatggag aagttatcat tgaaattcca acaagagctt gtgaaggaca agaaaatgct     1500

atcaagtccc tggagcatgt acaatttgaa gcaacaattg aatattcccg aagaggagac     1560

cttcatgtca cacttacttc tgctgctgga actagcactg tgctcttggc tgaaagagaa     1620

cgggatacat ctcctaatgg ctttaagaac tgggacttca tgtctgttca cacatgggga     1680

gagaacccta taggtacttg gactttgaga attacagaca tgtctggaag aattcaaaat     1740

gaaggaagaa ttgtgaactg gaagctgatt ttgcacggga cctcttctca gccagagcat     1800

atgaagcagc ctcgtgtgta cacgtcctac aacactgttc agaatgacag aagaggggtg     1860

gagaagatgg tggatccagg ggaggagcag cccacacaag agaaccctaa ggagaacacc     1920

ctggtgtcca aaagccccag cagcagcagc gtagggggcc ggagggatga gttggaggag     1980

ggagcccctt cccaggccat gctgcgactc ctgcaaagtg ctttcagtaa aaactcaccg     2040

ccaaagcaat caccaaagaa gtccccaagt gcaaagctca acatccctta tgaaaacttc     2100

tacgaagccc tggaaaagct gaacaaacct tcccagctta aagactctga agacagtctg     2160

tataatgact atgttgatgt tttttataac actaaacctt acaagcacag agacgaccgg     2220

ctgcttcaag ctctggtgga cattctgaat gaggaaaatt aa                        2262


<210>  8
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Arg Arg Ala Trp Ser Leu Gln Cys Thr Ala Phe Val Leu Phe 
1               5                   10                  15      


Cys Ala Trp Cys Ala Leu Asn Ser Ala Lys Ala Lys Arg Gln Phe Val 
            20                  25                  30          


Asn Glu Trp Ala Ala Glu Ile Pro Gly Gly Pro Glu Ala Ala Ser Ala 
        35                  40                  45              


Ile Ala Glu Glu Leu Gly Tyr Asp Leu Leu Gly Gln Ile Gly Ser Leu 
    50                  55                  60                  


Glu Asn His Tyr Leu Phe Lys His Lys Asn His Pro Arg Arg Ser Arg 
65                  70                  75                  80  


Arg Ser Ala Phe His Ile Thr Lys Arg Leu Ser Asp Asp Asp Arg Val 
                85                  90                  95      


Ile Trp Ala Glu Gln Gln Tyr Glu Lys Glu Arg Ser Lys Arg Ser Ala 
            100                 105                 110         


Leu Arg Asp Ser Ala Leu Asn Leu Phe Asn Asp Pro Met Trp Asn Gln 
        115                 120                 125             


Gln Trp Tyr Leu Gln Asp Thr Arg Met Thr Ala Ala Leu Pro Lys Leu 
    130                 135                 140                 


Asp Leu His Val Ile Pro Val Trp Gln Lys Gly Ile Thr Gly Lys Gly 
145                 150                 155                 160 


Val Val Ile Thr Val Leu Asp Asp Gly Leu Glu Trp Asn His Thr Asp 
                165                 170                 175     


Ile Tyr Ala Asn Tyr Asp Pro Glu Ala Ser Tyr Asp Phe Asn Asp Asn 
            180                 185                 190         


Asp His Asp Pro Phe Pro Arg Tyr Asp Pro Thr Asn Glu Asn Lys His 
        195                 200                 205             


Gly Thr Arg Cys Ala Gly Glu Ile Ala Met Gln Ala Asn Asn His Lys 
    210                 215                 220                 


Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Gly Gly Ile Arg Met 
225                 230                 235                 240 


Leu Asp Gly Ile Val Thr Asp Ala Ile Glu Ala Ser Ser Ile Gly Phe 
                245                 250                 255     


Asn Pro Gly His Val Asp Ile Tyr Ser Ala Ser Trp Gly Pro Asn Asp 
            260                 265                 270         


Asp Gly Lys Thr Val Glu Gly Pro Gly Arg Leu Ala Gln Lys Ala Phe 
        275                 280                 285             


Glu Tyr Gly Val Lys Gln Gly Arg Gln Gly Lys Gly Ser Ile Phe Val 
    290                 295                 300                 


Trp Ala Ser Gly Asn Gly Gly Arg Gln Gly Asp Asn Cys Asp Cys Asp 
305                 310                 315                 320 


Gly Tyr Thr Asp Ser Ile Tyr Thr Ile Ser Ile Ser Ser Ala Ser Gln 
                325                 330                 335     


Gln Gly Leu Ser Pro Trp Tyr Ala Glu Lys Cys Ser Ser Thr Leu Ala 
            340                 345                 350         


Thr Ser Tyr Ser Ser Gly Asp Tyr Thr Asp Gln Arg Ile Thr Ser Ala 
        355                 360                 365             


Asp Leu His Asn Asp Cys Thr Glu Thr His Thr Gly Thr Ser Ala Ser 
    370                 375                 380                 


Ala Pro Leu Ala Ala Gly Ile Phe Ala Leu Ala Leu Glu Ala Asn Pro 
385                 390                 395                 400 


Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Trp Thr Ser Glu 
                405                 410                 415     


Tyr Asp Pro Leu Ala Asn Asn Pro Gly Trp Lys Lys Asn Gly Ala Gly 
            420                 425                 430         


Leu Met Val Asn Ser Arg Phe Gly Phe Gly Leu Leu Asn Ala Lys Ala 
        435                 440                 445             


Leu Val Asp Leu Ala Asp Pro Arg Thr Trp Arg Ser Val Pro Glu Lys 
    450                 455                 460                 


Lys Glu Cys Val Val Lys Asp Asn Asp Phe Glu Pro Arg Ala Leu Lys 
465                 470                 475                 480 


Ala Asn Gly Glu Val Ile Ile Glu Ile Pro Thr Arg Ala Cys Glu Gly 
                485                 490                 495     


Gln Glu Asn Ala Ile Lys Ser Leu Glu His Val Gln Phe Glu Ala Thr 
            500                 505                 510         


Ile Glu Tyr Ser Arg Arg Gly Asp Leu His Val Thr Leu Thr Ser Ala 
        515                 520                 525             


Ala Gly Thr Ser Thr Val Leu Leu Ala Glu Arg Glu Arg Asp Thr Ser 
    530                 535                 540                 


Pro Asn Gly Phe Lys Asn Trp Asp Phe Met Ser Val His Thr Trp Gly 
545                 550                 555                 560 


Glu Asn Pro Ile Gly Thr Trp Thr Leu Arg Ile Thr Asp Met Ser Gly 
                565                 570                 575     


Arg Ile Gln Asn Glu Gly Arg Ile Val Asn Trp Lys Leu Ile Leu His 
            580                 585                 590         


Gly Thr Ser Ser Gln Pro Glu His Met Lys Gln Pro Arg Val Tyr Thr 
        595                 600                 605             


Ser Tyr Asn Thr Val Gln Asn Asp Arg Arg Gly Val Glu Lys Met Val 
    610                 615                 620                 


Asp Pro Gly Glu Glu Gln Pro Thr Gln Glu Asn Pro Lys Glu Asn Thr 
625                 630                 635                 640 


Leu Val Ser Lys Ser Pro Ser Ser Ser Ser Val Gly Gly Arg Arg Asp 
                645                 650                 655     


Glu Leu Glu Glu Gly Ala Pro Ser Gln Ala Met Leu Arg Leu Leu Gln 
            660                 665                 670         


Ser Ala Phe Ser Lys Asn Ser Pro Pro Lys Gln Ser Pro Lys Lys Ser 
        675                 680                 685             


Pro Ser Ala Lys Leu Asn Ile Pro Tyr Glu Asn Phe Tyr Glu Ala Leu 
    690                 695                 700                 


Glu Lys Leu Asn Lys Pro Ser Gln Leu Lys Asp Ser Glu Asp Ser Leu 
705                 710                 715                 720 


Tyr Asn Asp Tyr Val Asp Val Phe Tyr Asn Thr Lys Pro Tyr Lys His 
                725                 730                 735     


Arg Asp Asp Arg Leu Leu Gln Ala Leu Val Asp Ile Leu Asn Glu Glu 
            740                 745                 750         


Asn 
    


<210>  9
<211>  1917
<212>  DNA
<213>  Homo sapiens

<400>  9
atgaagggtg gttgtgtctc ccagtggaag gcggccgccg ggttcctctt ctgtgtcatg       60

gtttttgcat ctgctgagcg accggtcttc acgaatcatt ttcttgtgga gttgcataaa      120

gggggagagg acaaagctcg ccaagttgca gcagaacacg gctttggagt ccgaaagctt      180

ccctttgctg aaggtctgta ccacttttat cacaatggcc ttgcaaaggc caagagaaga      240

cgcagcctac accacaagca gcagctggag agagacccca gggtaaagat ggctttgcag      300

caggaaggat ttgaccgaaa aaagcgaggt tacagagaca tcaatgagat cgacatcaac      360

atgaacgatc ctctttttac aaagcagtgg tatctgatca atactgggca agctgatggc      420

actcctggcc ttgatttgaa tgtggctgaa gcctgggagc tgggatacac agggaaaggt      480

gttaccattg gaattatgga tgatgggatt gactatctcc acccggacct ggcctccaac      540

tataatgccg aagcaagtta cgacttcagc agcaacgacc cctatcctta ccctcggtac      600

acagatgact ggtttaacag ccacgggacc cgatgtgcag gagaagtttc tgctgccgcc      660

aacaacaata tctgtggagt tggagtagca tacaactcca aggttgcagg catccggatg      720

ctggaccagc cattcatgac agacatcatc gaggcctcct ccatcagtca tatgccacag      780

ctgattgaca tctacagcgc cagctggggc cccacagaca acggcaagac agtggatggg      840

ccccgggagc tcacgctgca ggccatggcc gatggcgtga acaagggccg cggcggcaaa      900

ggcagcatct acgtgtgggc ctccggggac ggcggcagct atgacgactg caactgcgac      960

ggctacgcct ccagcatgtg gaccatctcc atcaactcag ccatcaacga cggcaggact     1020

gccctgtacg acgagagctg ctcttccacc ttggcttcca ccttcagcaa cgggaggaaa     1080

aggaaccccg aggccggtgt ggcaaccaca gatttgtacg gcaactgcac tctgaggcat     1140

tctgggacat ctgcagctgc ccccgaggca gctggtgtgt ttgcactggc tctggaggct     1200

aacctgggtc tgacctggcg ggacatgcag catctgactg tgctcacctc caaacggaac     1260

cagcttcacg acgaggtcca tcagtggcgg cgcaatgggg tcggcctgga atttaatcac     1320

ctctttggct acggggtcct tgatgcaggt gccatggtga aaatggctaa agactggaaa     1380

accgtgcctg agagattcca ctgtgtggga ggctccgtgc aggaccctga gaaaatacca     1440

tccactggca agttggtgct gacactcaca accgacgcct gtgaggggaa ggaaaatttt     1500

gtccgctacc tggagcatgt ccaggctgtc atcacggtca acgcaaccag aagaggagac     1560

ctgaacatca acatgacttc ccctatgggc accaagtcca ttttgctgag ccggcgtcca     1620

agggatgacg actccaaggt gggctttgac aagtggcctt tcatgaccac tcacacgtgg     1680

ggggaagacg cccgaggcac ctggaccctg gagctgggat ttgtcggcag cgccccgcag     1740

aagggggtgc tgaaggagtg gaccctgatg ctgcatggca ctcagagtgc cccgtacatc     1800

gaccaggtgg tgcgggatta ccagtccaag ttggccatgt ccaagaaaga ggagctggag     1860

gaagagctgg acgaagccgt ggagagaagc ctgaaaagca tccttaacaa gaactag        1917


<210>  10
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Gly Gly Cys Val Ser Gln Trp Lys Ala Ala Ala Gly Phe Leu 
1               5                   10                  15      


Phe Cys Val Met Val Phe Ala Ser Ala Glu Arg Pro Val Phe Thr Asn 
            20                  25                  30          


His Phe Leu Val Glu Leu His Lys Gly Gly Glu Asp Lys Ala Arg Gln 
        35                  40                  45              


Val Ala Ala Glu His Gly Phe Gly Val Arg Lys Leu Pro Phe Ala Glu 
    50                  55                  60                  


Gly Leu Tyr His Phe Tyr His Asn Gly Leu Ala Lys Ala Lys Arg Arg 
65                  70                  75                  80  


Arg Ser Leu His His Lys Gln Gln Leu Glu Arg Asp Pro Arg Val Lys 
                85                  90                  95      


Met Ala Leu Gln Gln Glu Gly Phe Asp Arg Lys Lys Arg Gly Tyr Arg 
            100                 105                 110         


Asp Ile Asn Glu Ile Asp Ile Asn Met Asn Asp Pro Leu Phe Thr Lys 
        115                 120                 125             


Gln Trp Tyr Leu Ile Asn Thr Gly Gln Ala Asp Gly Thr Pro Gly Leu 
    130                 135                 140                 


Asp Leu Asn Val Ala Glu Ala Trp Glu Leu Gly Tyr Thr Gly Lys Gly 
145                 150                 155                 160 


Val Thr Ile Gly Ile Met Asp Asp Gly Ile Asp Tyr Leu His Pro Asp 
                165                 170                 175     


Leu Ala Ser Asn Tyr Asn Ala Glu Ala Ser Tyr Asp Phe Ser Ser Asn 
            180                 185                 190         


Asp Pro Tyr Pro Tyr Pro Arg Tyr Thr Asp Asp Trp Phe Asn Ser His 
        195                 200                 205             


Gly Thr Arg Cys Ala Gly Glu Val Ser Ala Ala Ala Asn Asn Asn Ile 
    210                 215                 220                 


Cys Gly Val Gly Val Ala Tyr Asn Ser Lys Val Ala Gly Ile Arg Met 
225                 230                 235                 240 


Leu Asp Gln Pro Phe Met Thr Asp Ile Ile Glu Ala Ser Ser Ile Ser 
                245                 250                 255     


His Met Pro Gln Leu Ile Asp Ile Tyr Ser Ala Ser Trp Gly Pro Thr 
            260                 265                 270         


Asp Asn Gly Lys Thr Val Asp Gly Pro Arg Glu Leu Thr Leu Gln Ala 
        275                 280                 285             


Met Ala Asp Gly Val Asn Lys Gly Arg Gly Gly Lys Gly Ser Ile Tyr 
    290                 295                 300                 


Val Trp Ala Ser Gly Asp Gly Gly Ser Tyr Asp Asp Cys Asn Cys Asp 
305                 310                 315                 320 


Gly Tyr Ala Ser Ser Met Trp Thr Ile Ser Ile Asn Ser Ala Ile Asn 
                325                 330                 335     


Asp Gly Arg Thr Ala Leu Tyr Asp Glu Ser Cys Ser Ser Thr Leu Ala 
            340                 345                 350         


Ser Thr Phe Ser Asn Gly Arg Lys Arg Asn Pro Glu Ala Gly Val Ala 
        355                 360                 365             


Thr Thr Asp Leu Tyr Gly Asn Cys Thr Leu Arg His Ser Gly Thr Ser 
    370                 375                 380                 


Ala Ala Ala Pro Glu Ala Ala Gly Val Phe Ala Leu Ala Leu Glu Ala 
385                 390                 395                 400 


Asn Leu Gly Leu Thr Trp Arg Asp Met Gln His Leu Thr Val Leu Thr 
                405                 410                 415     


Ser Lys Arg Asn Gln Leu His Asp Glu Val His Gln Trp Arg Arg Asn 
            420                 425                 430         


Gly Val Gly Leu Glu Phe Asn His Leu Phe Gly Tyr Gly Val Leu Asp 
        435                 440                 445             


Ala Gly Ala Met Val Lys Met Ala Lys Asp Trp Lys Thr Val Pro Glu 
    450                 455                 460                 


Arg Phe His Cys Val Gly Gly Ser Val Gln Asp Pro Glu Lys Ile Pro 
465                 470                 475                 480 


Ser Thr Gly Lys Leu Val Leu Thr Leu Thr Thr Asp Ala Cys Glu Gly 
                485                 490                 495     


Lys Glu Asn Phe Val Arg Tyr Leu Glu His Val Gln Ala Val Ile Thr 
            500                 505                 510         


Val Asn Ala Thr Arg Arg Gly Asp Leu Asn Ile Asn Met Thr Ser Pro 
        515                 520                 525             


Met Gly Thr Lys Ser Ile Leu Leu Ser Arg Arg Pro Arg Asp Asp Asp 
    530                 535                 540                 


Ser Lys Val Gly Phe Asp Lys Trp Pro Phe Met Thr Thr His Thr Trp 
545                 550                 555                 560 


Gly Glu Asp Ala Arg Gly Thr Trp Thr Leu Glu Leu Gly Phe Val Gly 
                565                 570                 575     


Ser Ala Pro Gln Lys Gly Val Leu Lys Glu Trp Thr Leu Met Leu His 
            580                 585                 590         


Gly Thr Gln Ser Ala Pro Tyr Ile Asp Gln Val Val Arg Asp Tyr Gln 
        595                 600                 605             


Ser Lys Leu Ala Met Ser Lys Lys Glu Glu Leu Glu Glu Glu Leu Asp 
    610                 615                 620                 


Glu Ala Val Glu Arg Ser Leu Lys Ser Ile Leu Asn Lys Asn 
625                 630                 635             


<210>  11
<211>  2385
<212>  DNA
<213>  Homo sapiens

<400>  11
atggagctga ggccctggtt gctatgggtg gtagcagcaa caggaacctt ggtcctgcta       60

gcagctgatg ctcagggcca gaaggtcttc accaacacgt gggctgtgcg catccctgga      120

ggcccagcgg tggccaacag tgtggcacgg aagcatgggt tcctcaacct gggccagatc      180

ttcggggact attaccactt ctggcatcga ggagtgacga agcggtccct gtcgcctcac      240

cgcccgcggc acagccggct gcagagggag cctcaagtac agtggctgga acagcaggtg      300

gcaaagcgac ggactaaacg ggacgtgtac caggagccca cagaccccaa gtttcctcag      360

cagtggtacc tgtctggtgt cactcagcgg gacctgaatg tgaaggcggc ctgggcgcag      420

ggctacacag ggcacggcat tgtggtctcc attctggacg atggcatcga gaagaaccac      480

ccggacttgg caggcaatta tgatcctggg gccagttttg atgtcaatga ccaggaccct      540

gacccccagc ctcggtacac acagatgaat gacaacaggc acggcacacg gtgtgcgggg      600

gaagtggctg cggtggccaa caacggtgtc tgtggtgtag gtgtggccta caacgcccgc      660

attggagggg tgcgcatgct ggatggcgag gtgacagatg cagtggaggc acgctcgctg      720

ggcctgaacc ccaaccacat ccacatctac agtgccagct ggggccccga ggatgacggc      780

aagacagtgg atgggccagc ccgcctcgcc gaggaggcct tcttccgtgg ggttagccag      840

ggccgagggg ggctgggctc catctttgtc tgggcctcgg ggaacggggg ccgggaacat      900

gacagctgca actgcgacgg ctacaccaac agtatctaca cgctgtccat cagcagcgcc      960

acgcagtttg gcaacgtgcc gtggtacagc gaggcctgct cgtccacact ggccacgacc     1020

tacagcagtg gcaaccagaa tgagaagcag atcgtgacga ctgacttgcg gcagaagtgc     1080

acggagtctc acacgggcac ctcagcctct gcccccttag cagccggcat cattgctctc     1140

accctggagg ccaataagaa cctcacatgg cgggacatgc aacacctggt ggtacagacc     1200

tcgaagccag cccacctcaa tgccaacgac tgggccacca atggtgtggg ccggaaagtg     1260

agccactcat atggctacgg gcttttggac gcaggcgcca tggtggccct ggcccagaat     1320

tggaccacag tggcccccca gcggaagtgc atcatcgaca tcctcaccga gcccaaagac     1380

atcgggaaac ggctcgaggt gcggaagacc gtgaccgcgt gcctgggcga gcccaaccac     1440

atcactcggc tggagcacgc tcaggcgcgg ctcaccctgt cctataatcg ccgtggcgac     1500

ctggccatcc acctggtcag ccccatgggc acccgctcca ccctgctggc agccaggcca     1560

catgactact ccgcagatgg gtttaatgac tgggccttca tgacaactca ttcctgggat     1620

gaggatccct ctggcgagtg ggtcctagag attgaaaaca ccagcgaagc caacaactat     1680

gggacgctga ccaagttcac cctcgtactc tatggcaccg cccctgaggg gctgcccgta     1740

cctccagaaa gcagtggctg caagaccctc acgtccagtc aggcctgtgt ggtgtgcgag     1800

gaaggcttct ccctgcacca gaagagctgt gtccagcact gccctccagg cttcgccccc     1860

caagtcctcg atacgcacta tagcaccgag aatgacgtgg agaccatccg ggccagcgtc     1920

tgcgccccct gccacgcctc atgtgccaca tgccaggggc cggccctgac agactgcctc     1980

agctgcccca gccacgcctc cttggaccct gtggagcaga cttgctcccg gcaaagccag     2040

agcagccgag agtccccgcc acagcagcag ccacctcggc tgcccccgga ggtggaggcg     2100

gggcaacggc tgcgggcagg gctgctgccc tcacacctgc ctgaggtggt ggccggcctc     2160

agctgcgcct tcatcgtgct ggtcttcgtc actgtcttcc tggtcctgca gctgcgctct     2220

ggctttagtt ttcggggggt gaaggtgtac accatggacc gtggcctcat ctcctacaag     2280

gggctgcccc ctgaagcctg gcaggaggag tgcccgtctg actcagaaga ggacgagggc     2340

cggggcgaga ggaccgcctt tatcaaagac cagagcgccc tctga                     2385


<210>  12
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Leu Arg Pro Trp Leu Leu Trp Val Val Ala Ala Thr Gly Thr 
1               5                   10                  15      


Leu Val Leu Leu Ala Ala Asp Ala Gln Gly Gln Lys Val Phe Thr Asn 
            20                  25                  30          


Thr Trp Ala Val Arg Ile Pro Gly Gly Pro Ala Val Ala Asn Ser Val 
        35                  40                  45              


Ala Arg Lys His Gly Phe Leu Asn Leu Gly Gln Ile Phe Gly Asp Tyr 
    50                  55                  60                  


Tyr His Phe Trp His Arg Gly Val Thr Lys Arg Ser Leu Ser Pro His 
65                  70                  75                  80  


Arg Pro Arg His Ser Arg Leu Gln Arg Glu Pro Gln Val Gln Trp Leu 
                85                  90                  95      


Glu Gln Gln Val Ala Lys Arg Arg Thr Lys Arg Asp Val Tyr Gln Glu 
            100                 105                 110         


Pro Thr Asp Pro Lys Phe Pro Gln Gln Trp Tyr Leu Ser Gly Val Thr 
        115                 120                 125             


Gln Arg Asp Leu Asn Val Lys Ala Ala Trp Ala Gln Gly Tyr Thr Gly 
    130                 135                 140                 


His Gly Ile Val Val Ser Ile Leu Asp Asp Gly Ile Glu Lys Asn His 
145                 150                 155                 160 


Pro Asp Leu Ala Gly Asn Tyr Asp Pro Gly Ala Ser Phe Asp Val Asn 
                165                 170                 175     


Asp Gln Asp Pro Asp Pro Gln Pro Arg Tyr Thr Gln Met Asn Asp Asn 
            180                 185                 190         


Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Val Ala Asn Asn 
        195                 200                 205             


Gly Val Cys Gly Val Gly Val Ala Tyr Asn Ala Arg Ile Gly Gly Val 
    210                 215                 220                 


Arg Met Leu Asp Gly Glu Val Thr Asp Ala Val Glu Ala Arg Ser Leu 
225                 230                 235                 240 


Gly Leu Asn Pro Asn His Ile His Ile Tyr Ser Ala Ser Trp Gly Pro 
                245                 250                 255     


Glu Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Arg Leu Ala Glu Glu 
            260                 265                 270         


Ala Phe Phe Arg Gly Val Ser Gln Gly Arg Gly Gly Leu Gly Ser Ile 
        275                 280                 285             


Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu His Asp Ser Cys Asn 
    290                 295                 300                 


Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Leu Ser Ile Ser Ser Ala 
305                 310                 315                 320 


Thr Gln Phe Gly Asn Val Pro Trp Tyr Ser Glu Ala Cys Ser Ser Thr 
                325                 330                 335     


Leu Ala Thr Thr Tyr Ser Ser Gly Asn Gln Asn Glu Lys Gln Ile Val 
            340                 345                 350         


Thr Thr Asp Leu Arg Gln Lys Cys Thr Glu Ser His Thr Gly Thr Ser 
        355                 360                 365             


Ala Ser Ala Pro Leu Ala Ala Gly Ile Ile Ala Leu Thr Leu Glu Ala 
    370                 375                 380                 


Asn Lys Asn Leu Thr Trp Arg Asp Met Gln His Leu Val Val Gln Thr 
385                 390                 395                 400 


Ser Lys Pro Ala His Leu Asn Ala Asn Asp Trp Ala Thr Asn Gly Val 
                405                 410                 415     


Gly Arg Lys Val Ser His Ser Tyr Gly Tyr Gly Leu Leu Asp Ala Gly 
            420                 425                 430         


Ala Met Val Ala Leu Ala Gln Asn Trp Thr Thr Val Ala Pro Gln Arg 
        435                 440                 445             


Lys Cys Ile Ile Asp Ile Leu Thr Glu Pro Lys Asp Ile Gly Lys Arg 
    450                 455                 460                 


Leu Glu Val Arg Lys Thr Val Thr Ala Cys Leu Gly Glu Pro Asn His 
465                 470                 475                 480 


Ile Thr Arg Leu Glu His Ala Gln Ala Arg Leu Thr Leu Ser Tyr Asn 
                485                 490                 495     


Arg Arg Gly Asp Leu Ala Ile His Leu Val Ser Pro Met Gly Thr Arg 
            500                 505                 510         


Ser Thr Leu Leu Ala Ala Arg Pro His Asp Tyr Ser Ala Asp Gly Phe 
        515                 520                 525             


Asn Asp Trp Ala Phe Met Thr Thr His Ser Trp Asp Glu Asp Pro Ser 
    530                 535                 540                 


Gly Glu Trp Val Leu Glu Ile Glu Asn Thr Ser Glu Ala Asn Asn Tyr 
545                 550                 555                 560 


Gly Thr Leu Thr Lys Phe Thr Leu Val Leu Tyr Gly Thr Ala Pro Glu 
                565                 570                 575     


Gly Leu Pro Val Pro Pro Glu Ser Ser Gly Cys Lys Thr Leu Thr Ser 
            580                 585                 590         


Ser Gln Ala Cys Val Val Cys Glu Glu Gly Phe Ser Leu His Gln Lys 
        595                 600                 605             


Ser Cys Val Gln His Cys Pro Pro Gly Phe Ala Pro Gln Val Leu Asp 
    610                 615                 620                 


Thr His Tyr Ser Thr Glu Asn Asp Val Glu Thr Ile Arg Ala Ser Val 
625                 630                 635                 640 


Cys Ala Pro Cys His Ala Ser Cys Ala Thr Cys Gln Gly Pro Ala Leu 
                645                 650                 655     


Thr Asp Cys Leu Ser Cys Pro Ser His Ala Ser Leu Asp Pro Val Glu 
            660                 665                 670         


Gln Thr Cys Ser Arg Gln Ser Gln Ser Ser Arg Glu Ser Pro Pro Gln 
        675                 680                 685             


Gln Gln Pro Pro Arg Leu Pro Pro Glu Val Glu Ala Gly Gln Arg Leu 
    690                 695                 700                 


Arg Ala Gly Leu Leu Pro Ser His Leu Pro Glu Val Val Ala Gly Leu 
705                 710                 715                 720 


Ser Cys Ala Phe Ile Val Leu Val Phe Val Thr Val Phe Leu Val Leu 
                725                 730                 735     


Gln Leu Arg Ser Gly Phe Ser Phe Arg Gly Val Lys Val Tyr Thr Met 
            740                 745                 750         


Asp Arg Gly Leu Ile Ser Tyr Lys Gly Leu Pro Pro Glu Ala Trp Gln 
        755                 760                 765             


Glu Glu Cys Pro Ser Asp Ser Glu Glu Asp Glu Gly Arg Gly Glu Arg 
    770                 775                 780                 


Thr Ala Phe Ile Lys Asp Gln Ser Ala Leu 
785                 790                 


<210>  13
<211>  2268
<212>  DNA
<213>  Homo sapiens

<400>  13
atgcggcccg ccccgattgc gctgtggctg cgcctggtct tggccctggc ccttgtccgc       60

ccccgggctg tggggtgggc cccggtccga gcccccatct atgtcagcag ctgggccgtc      120

caggtgtccc agggtaaccg ggaggtcgag cgcctggcac gcaaattcgg cttcgtcaac      180

ctggggccga tcttctctga cgggcagtac tttcacctgc ggcaccgggg cgtggtccag      240

cagtccctga ccccgcactg gggccaccgc ctgcacctga agaaaaaccc caaggtgcag      300

tggttccagc agcagacgct gcagcggcgg gtgaaacgct ctgtcgtggt gcccacggac      360

ccctggttct ccaagcagtg gtacatgaac agcgaggccc aaccagacct gagcatcctg      420

caggcctgga gtcaggggct gtcaggccag ggcatcgtgg tctctgtgct ggacgatggc      480

atcgagaagg accacccgga cctctgggcc aactacgacc ccctggccag ctatgacttc      540

aatgactacg acccggaccc ccagccccgc tacaccccca gcaaagagaa ccggcacggg      600

acccgctgtg ctggggaggt ggccgcgatg gccaacaatg gcttctgtgg tgtgggggtc      660

gctttcaacg cccgaatcgg aggcgtacgg atgctggacg gtaccatcac cgatgtcatc      720

gaggcccagt cgctgagcct gcagccgcag cacatccaca tttacagcgc cagctggggt      780

cccgaggacg acggccgcac ggtggacggc cccggcatcc tcacccgcga ggccttccgg      840

cgtggtgtga ccaagggccg cggcgggctg ggcacgctct tcatctgggc ctcgggcaac      900

ggcggcctgc actacgacaa ctgcaactgc gacggctaca ccaacagcat ccacacgctt      960

tccgtgggca gcaccaccca gcagggccgc gtgccctggt acagcgaagc ctgcgcctcc     1020

accctcacca ccacctacag cagcggcgtg gccaccgacc cccagatcgt caccacggac     1080

ctgcatcacg ggtgcacaga ccagcacacg ggcacctcgg cctcagcccc actggcggcc     1140

ggcatgatcg ccctagcgct ggaggccaac ccgttcctga cgtggagaga catgcagcac     1200

ctggtggtcc gcgcgtccaa gccggcgcac ctgcaggccg aggactggag gaccaacggc     1260

gtggggcgcc aagtgagcca tcactacgga tacgggctgc tggacgccgg gctgctggtg     1320

gacaccgccc gcacctggct gcccacccag ccgcagagga agtgcgccgt ccgggtccag     1380

agccgcccca cccccatcct gccgctgatc tacatcaggg aaaacgtatc ggcctgcgcc     1440

ggcctccaca actccatccg ctcgctggag cacgtgcagg cgcagctgac gctgtcctac     1500

agccggcgcg gagacctgga gatctcgctc accagcccca tgggcacgcg ctccacactc     1560

gtggccatac gacccttgga cgtcagcact gaaggctaca acaactgggt cttcatgtcc     1620

acccacttct gggatgagaa cccacagggc gtgtggaccc tgggcctaga gaacaagggc     1680

tactatttca acacggggac gttgtaccgc tacacgctgc tgctctatgg gacggccgag     1740

gacatgacag cgcggcctac aggcccccag gtgaccagca gcgcgtgtgt gcagcgggac     1800

acagaggggc tgtgccaggc gtgtgacggc cccgcctaca tcctgggaca gctctgcctg     1860

gcctactgcc ccccgcggtt cttcaaccac acaaggctgg tgaccgctgg gcctgggcac     1920

acggcggcgc ccgcgctgag ggtctgctcc agctgccatg cctcctgcta cacctgccgc     1980

ggcggctccc cgagggactg cacctcctgt cccccatcct ccacgctgga ccagcagcag     2040

ggctcctgca tgggacccac cacccccgac agccgccccc ggcttagagc tgccgcctgt     2100

ccccaccacc gctgcccagc ctcggccatg gtgctgagcc tcctggccgt gaccctcgga     2160

ggccccgtcc tctgcggcat gtccatggac ctcccactat acgcctggct ctcccgtgcc     2220

agggccaccc ccaccaaacc ccaggtctgg ctgccagctg gaacctga                  2268


<210>  14
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Arg Pro Ala Pro Ile Ala Leu Trp Leu Arg Leu Val Leu Ala Leu 
1               5                   10                  15      


Ala Leu Val Arg Pro Arg Ala Val Gly Trp Ala Pro Val Arg Ala Pro 
            20                  25                  30          


Ile Tyr Val Ser Ser Trp Ala Val Gln Val Ser Gln Gly Asn Arg Glu 
        35                  40                  45              


Val Glu Arg Leu Ala Arg Lys Phe Gly Phe Val Asn Leu Gly Pro Ile 
    50                  55                  60                  


Phe Ser Asp Gly Gln Tyr Phe His Leu Arg His Arg Gly Val Val Gln 
65                  70                  75                  80  


Gln Ser Leu Thr Pro His Trp Gly His Arg Leu His Leu Lys Lys Asn 
                85                  90                  95      


Pro Lys Val Gln Trp Phe Gln Gln Gln Thr Leu Gln Arg Arg Val Lys 
            100                 105                 110         


Arg Ser Val Val Val Pro Thr Asp Pro Trp Phe Ser Lys Gln Trp Tyr 
        115                 120                 125             


Met Asn Ser Glu Ala Gln Pro Asp Leu Ser Ile Leu Gln Ala Trp Ser 
    130                 135                 140                 


Gln Gly Leu Ser Gly Gln Gly Ile Val Val Ser Val Leu Asp Asp Gly 
145                 150                 155                 160 


Ile Glu Lys Asp His Pro Asp Leu Trp Ala Asn Tyr Asp Pro Leu Ala 
                165                 170                 175     


Ser Tyr Asp Phe Asn Asp Tyr Asp Pro Asp Pro Gln Pro Arg Tyr Thr 
            180                 185                 190         


Pro Ser Lys Glu Asn Arg His Gly Thr Arg Cys Ala Gly Glu Val Ala 
        195                 200                 205             


Ala Met Ala Asn Asn Gly Phe Cys Gly Val Gly Val Ala Phe Asn Ala 
    210                 215                 220                 


Arg Ile Gly Gly Val Arg Met Leu Asp Gly Thr Ile Thr Asp Val Ile 
225                 230                 235                 240 


Glu Ala Gln Ser Leu Ser Leu Gln Pro Gln His Ile His Ile Tyr Ser 
                245                 250                 255     


Ala Ser Trp Gly Pro Glu Asp Asp Gly Arg Thr Val Asp Gly Pro Gly 
            260                 265                 270         


Ile Leu Thr Arg Glu Ala Phe Arg Arg Gly Val Thr Lys Gly Arg Gly 
        275                 280                 285             


Gly Leu Gly Thr Leu Phe Ile Trp Ala Ser Gly Asn Gly Gly Leu His 
    290                 295                 300                 


Tyr Asp Asn Cys Asn Cys Asp Gly Tyr Thr Asn Ser Ile His Thr Leu 
305                 310                 315                 320 


Ser Val Gly Ser Thr Thr Gln Gln Gly Arg Val Pro Trp Tyr Ser Glu 
                325                 330                 335     


Ala Cys Ala Ser Thr Leu Thr Thr Thr Tyr Ser Ser Gly Val Ala Thr 
            340                 345                 350         


Asp Pro Gln Ile Val Thr Thr Asp Leu His His Gly Cys Thr Asp Gln 
        355                 360                 365             


His Thr Gly Thr Ser Ala Ser Ala Pro Leu Ala Ala Gly Met Ile Ala 
    370                 375                 380                 


Leu Ala Leu Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Met Gln His 
385                 390                 395                 400 


Leu Val Val Arg Ala Ser Lys Pro Ala His Leu Gln Ala Glu Asp Trp 
                405                 410                 415     


Arg Thr Asn Gly Val Gly Arg Gln Val Ser His His Tyr Gly Tyr Gly 
            420                 425                 430         


Leu Leu Asp Ala Gly Leu Leu Val Asp Thr Ala Arg Thr Trp Leu Pro 
        435                 440                 445             


Thr Gln Pro Gln Arg Lys Cys Ala Val Arg Val Gln Ser Arg Pro Thr 
    450                 455                 460                 


Pro Ile Leu Pro Leu Ile Tyr Ile Arg Glu Asn Val Ser Ala Cys Ala 
465                 470                 475                 480 


Gly Leu His Asn Ser Ile Arg Ser Leu Glu His Val Gln Ala Gln Leu 
                485                 490                 495     


Thr Leu Ser Tyr Ser Arg Arg Gly Asp Leu Glu Ile Ser Leu Thr Ser 
            500                 505                 510         


Pro Met Gly Thr Arg Ser Thr Leu Val Ala Ile Arg Pro Leu Asp Val 
        515                 520                 525             


Ser Thr Glu Gly Tyr Asn Asn Trp Val Phe Met Ser Thr His Phe Trp 
    530                 535                 540                 


Asp Glu Asn Pro Gln Gly Val Trp Thr Leu Gly Leu Glu Asn Lys Gly 
545                 550                 555                 560 


Tyr Tyr Phe Asn Thr Gly Thr Leu Tyr Arg Tyr Thr Leu Leu Leu Tyr 
                565                 570                 575     


Gly Thr Ala Glu Asp Met Thr Ala Arg Pro Thr Gly Pro Gln Val Thr 
            580                 585                 590         


Ser Ser Ala Cys Val Gln Arg Asp Thr Glu Gly Leu Cys Gln Ala Cys 
        595                 600                 605             


Asp Gly Pro Ala Tyr Ile Leu Gly Gln Leu Cys Leu Ala Tyr Cys Pro 
    610                 615                 620                 


Pro Arg Phe Phe Asn His Thr Arg Leu Val Thr Ala Gly Pro Gly His 
625                 630                 635                 640 


Thr Ala Ala Pro Ala Leu Arg Val Cys Ser Ser Cys His Ala Ser Cys 
                645                 650                 655     


Tyr Thr Cys Arg Gly Gly Ser Pro Arg Asp Cys Thr Ser Cys Pro Pro 
            660                 665                 670         


Ser Ser Thr Leu Asp Gln Gln Gln Gly Ser Cys Met Gly Pro Thr Thr 
        675                 680                 685             


Pro Asp Ser Arg Pro Arg Leu Arg Ala Ala Ala Cys Pro His His Arg 
    690                 695                 700                 


Cys Pro Ala Ser Ala Met Val Leu Ser Leu Leu Ala Val Thr Leu Gly 
705                 710                 715                 720 


Gly Pro Val Leu Cys Gly Met Ser Met Asp Leu Pro Leu Tyr Ala Trp 
                725                 730                 735     


Leu Ser Arg Ala Arg Ala Thr Pro Thr Lys Pro Gln Val Trp Leu Pro 
            740                 745                 750         


Ala Gly Thr 
        755 


<210>  15
<211>  729
<212>  DNA
<213>  Homo sapiens

<400>  15
atgggcacgc gctccacact cgtggccata cgacccttgg acgtcagcac tgaaggctac       60

aacaactggg tcttcatgtc cacccacttc tgggatgaga acccacaggg cgtgtggacc      120

ctgggcctag agaacaaggg ctactatttc aacacgggga cgttgtaccg ctacacgctg      180

ctgctctatg ggacggccga ggacatgaca gcgcggccta caggccccca ggtgaccagc      240

agcgcgtgtg tgcagcggga cacagagggg ctgtgccagg cgtgtgacgg ccccgcctac      300

atcctgggac agctctgcct ggcctactgc cccccgcggt tcttcaacca cacaaggctg      360

gtgaccgctg ggcctgggca cacggcggcg cccgcgctga gggtctgctc cagctgccat      420

gcctcctgct acacctgccg cggcggctcc ccgagggact gcacctcctg tcccccatcc      480

tccacgctgg accagcagca gggctcctgc atgggaccca ccacccccga cagccgcccc      540

cggcttagag ctgccgcctg tccccaccac cgctgcccag cctcggccat ggtgctgagc      600

ctcctggccg tgaccctcgg aggccccgtc ctctgcggca tgtccatgga cctcccacta      660

tacgcctggc tctcccgtgc cagggccacc cccaccaaac cccaggtctg gctgccagct      720

ggaacctga                                                              729


<210>  16
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Thr Arg Ser Thr Leu Val Ala Ile Arg Pro Leu Asp Val Ser 
1               5                   10                  15      


Thr Glu Gly Tyr Asn Asn Trp Val Phe Met Ser Thr His Phe Trp Asp 
            20                  25                  30          


Glu Asn Pro Gln Gly Val Trp Thr Leu Gly Leu Glu Asn Lys Gly Tyr 
        35                  40                  45              


Tyr Phe Asn Thr Gly Thr Leu Tyr Arg Tyr Thr Leu Leu Leu Tyr Gly 
    50                  55                  60                  


Thr Ala Glu Asp Met Thr Ala Arg Pro Thr Gly Pro Gln Val Thr Ser 
65                  70                  75                  80  


Ser Ala Cys Val Gln Arg Asp Thr Glu Gly Leu Cys Gln Ala Cys Asp 
                85                  90                  95      


Gly Pro Ala Tyr Ile Leu Gly Gln Leu Cys Leu Ala Tyr Cys Pro Pro 
            100                 105                 110         


Arg Phe Phe Asn His Thr Arg Leu Val Thr Ala Gly Pro Gly His Thr 
        115                 120                 125             


Ala Ala Pro Ala Leu Arg Val Cys Ser Ser Cys His Ala Ser Cys Tyr 
    130                 135                 140                 


Thr Cys Arg Gly Gly Ser Pro Arg Asp Cys Thr Ser Cys Pro Pro Ser 
145                 150                 155                 160 


Ser Thr Leu Asp Gln Gln Gln Gly Ser Cys Met Gly Pro Thr Thr Pro 
                165                 170                 175     


Asp Ser Arg Pro Arg Leu Arg Ala Ala Ala Cys Pro His His Arg Cys 
            180                 185                 190         


Pro Ala Ser Ala Met Val Leu Ser Leu Leu Ala Val Thr Leu Gly Gly 
        195                 200                 205             


Pro Val Leu Cys Gly Met Ser Met Asp Leu Pro Leu Tyr Ala Trp Leu 
    210                 215                 220                 


Ser Arg Ala Arg Ala Thr Pro Thr Lys Pro Gln Val Trp Leu Pro Ala 
225                 230                 235                 240 


Gly Thr 
        


<210>  17
<211>  2742
<212>  DNA
<213>  Homo sapiens

<400>  17
atgggctggg ggagccgctg ctgctgcccg ggacgtttgg acctgctgtg cgtgctggcg       60

ctgctcgggg gctgcctgct ccccgtgtgt cggacgcgcg tctacaccaa ccactgggca      120

gtcaaaatcg ccgggggctt cccggaggcc aaccgtatcg ccagcaagta cggattcatc      180

aacataggac agataggggc cctgaaggac tactaccact tctaccatag caggacgatt      240

aaaaggtcag ttatctcgag cagagggacc cacagtttca tttcaatgga accaaaggtg      300

gaatggatcc aacagcaagt ggtaaaaaag cggacaaaga gggattatga cttcagtcgt      360

gcccagtcta cctatttcaa tgatcccaag tggcccagca tgtggtatat gcactgcagt      420

gacaatacac atccctgcca gtctgacatg aatatcgaag gagcctggaa gagaggctac      480

acgggaaaga acattgtggt cactatcctg gatgacggaa ttgagagaac ccatccagat      540

ctgatgcaaa actacgatgc tctggcaagt tgcgacgtga atgggaatga cttggaccca      600

atgcctcgtt atgatgcaag caacgagaac aagcatggga ctcgctgtgc tggagaagtg      660

gcagccgctg caaacaattc gcactgcaca gtcggaattg ctttcaacgc caagatcgga      720

ggagtgcgaa tgctggacgg agatgtcacg gacatggttg aagcaaaatc agttagcttc      780

aacccccagc acgtgcacat ttacagcgcc agctggggcc cggatgatga tggcaagact      840

gtggacggac cagcccccct cacccggcaa gcctttgaaa acggcgttag aatggggcgg      900

agaggcctcg gctctgtgtt tgtttgggca tctggaaatg gtggaaggag caaagaccac      960

tgctcctgtg atggctacac caacagcatc tacaccatct ccatcagcag cactgcagaa     1020

agcggaaaga aaccttggta cctggaagag tgttcatcca cgctggccac aacctacagc     1080

agcggggagt cctacgataa gaaaatcatc actacagatc tgaggcagcg ttgcacggac     1140

aaccacactg ggacgtcagc ctcagccccc atggctgcag gcatcattgc gctggccctg     1200

gaagccaatc cgtttctgac ctggagagac gtacagcatg ttattgtcag gacttcccgt     1260

gcgggacatt tgaacgctaa tgactggaaa accaatgctg ctggttttaa ggtgagccat     1320

ctttatggat ttggactgat ggacgcagaa gccatggtga tggaggcaga gaagtggacc     1380

accgttcccc ggcagcacgt gtgtgtggag agcacagacc gacaaatcaa gacaatccgc     1440

cctaacagtg cagtgcgctc catctacaaa gcttcaggct gctcggataa ccccaaccgc     1500

catgtcaact acctggagca cgtcgttgtg cgcatcacca tcacccaccc caggagagga     1560

gacctggcca tctacctgac ctcgccctct ggaactaggt ctcagctttt ggccaacagg     1620

ctatttgatc actccatgga aggattcaaa aactgggagt tcatgaccat tcattgctgg     1680

ggagaaagag ctgctggtga ctgggtcctt gaagtttatg atactccctc tcagctaagg     1740

aactttaaga ctccaggtaa attgaaagaa tggtctttgg tcctctacgg cacctccgtg     1800

cagccatatt caccaaccaa tgaatttccg aaagtggaac ggttccgcta tagccgagtt     1860

gaagacccca cagacgacta tggcacagag gattatgcag gtccctgcga ccctgagtgc     1920

agtgaggttg gctgtgacgg gccaggacca gaccactgca atgactgttt gcactactac     1980

tacaagctga aaaacaatac caggatctgt gtctccagct gcccccctgg ccactaccac     2040

gccgacaaga agcgctgcag gaagtgtgcc cccaactgtg agtcctgctt tgggagccat     2100

ggtgaccaat gcatgtcctg caaatatgga tactttctga atgaagaaac caacagctgt     2160

gttactcact gccctgatgg gtcatatcag gataccaaga aaaatctttg ccggaaatgc     2220

agtgaaaact gcaagacatg tactgaattc cataactgta cagaatgtag ggatgggtta     2280

agcctgcagg gatcccggtg ctctgtctcc tgtgaagatg gacggtattt caacggccag     2340

gactgccagc cctgccaccg cttctgcgcc acttgtgctg gggcaggagc tgatgggtgc     2400

attaactgca cagagggcta cttcatggag gatgggagat gcgtgcagag ctgtagtatc     2460

agctattact ttgaccactc ttcagagaat ggatacaaat cctgcaaaaa atgtgatatc     2520

agttgtttga cgtgcaatgg cccaggattc aagaactgta caagctgccc tagtgggtat     2580

ctcttagact taggaatgtg tcaaatggga gccatttgca aggatgcaac ggaagagtcc     2640

tgggcggaag gaggcttctg tatgcttgtg aaaaagaaca atctgtgcca acggaaggtt     2700

cttcaacaac tttgctgcaa aacatgtaca tttcaaggct ga                        2742


<210>  18
<211>  913
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Ala Thr Glu Glu Ser 
865                 870                 875                 880 


Trp Ala Glu Gly Gly Phe Cys Met Leu Val Lys Lys Asn Asn Leu Cys 
                885                 890                 895     


Gln Arg Lys Val Leu Gln Gln Leu Cys Cys Lys Thr Cys Thr Phe Gln 
            900                 905                 910         


Gly 
    


<210>  19
<211>  2910
<212>  DNA
<213>  Homo sapiens

<400>  19
atgcctccgc gcgcgccgcc tgcgcccggg ccccggccgc cgccccgggc cgccgccgcc       60

accgacaccg ccgcgggcgc ggggggcgcg gggggcgcgg ggggcgccgg cgggcccggg      120

ttccggccgc tcgcgccgcg tccctggcgc tggctgctgc tgctggcgct gcctgccgcc      180

tgctccgcgc ccccgccgcg ccccgtctac accaaccact gggcggtgca agtgctgggc      240

ggcccggccg aggcggaccg cgtggcggcg gcgcacggct acctcaactt gggccagatt      300

ggaaacctgg aagattacta ccatttttat cacagcaaaa cctttaaaag atcaaccttg      360

agtagcagag gccctcacac cttcctcaga atggaccccc aggtgaaatg gctccagcaa      420

caggaagtga aacgaagggt gaagagacag gtgcgaagtg acccgcaggc cctttacttc      480

aacgacccca tttggtccaa catgtggtac ctgcattgtg gcgacaagaa cagtcgctgc      540

cggtcggaaa tgaatgtcca ggcagcgtgg aagaggggct acacaggaaa aaacgtggtg      600

gtcaccatcc ttgatgatgg catagagaga aatcaccctg acctggcccc aaattatgat      660

tcctacgcca gctacgacgt gaacggcaat gattatgacc catctccacg atatgatgcc      720

agcaatgaaa ataaacacgg cactcgttgt gcgggagaag ttgctgcttc agcaaacaat      780

tcctactgca tcgtgggcat agcgtacaat gccaaaatag gaggcatccg catgctggac      840

ggcgatgtca cagatgtggt cgaggcaaag tcgctgggca tcagacccaa ctacatcgac      900

atttacagtg ccagctgggg gccggacgac gacggcaaga cggtggacgg gcccggccga      960

ctggctaagc aggctttcga gtatggcatt aaaaagggcc ggcagggcct gggctccatt     1020

ttcgtctggg catctgggaa tggcgggaga gagggggact actgctcgtg cgatggctac     1080

accaacagca tctacaccat ctccgtcagc agcgccaccg agaatggcta caagccctgg     1140

tacctggaag agtgtgcctc caccctggcc accacctaca gcagtggggc cttttatgag     1200

cgaaaaatcg tcaccacgga tctgcgtcag cgctgtaccg atggccacac tgggacctca     1260

gtctctgccc ccatggtggc gggcatcatc gccttggctc tagaagcaaa cagccagtta     1320

acctggaggg acgtccagca cctgctagtg aagacatccc ggccggccca cctgaaagcg     1380

agcgactgga aagtaaacgg cgcgggtcat aaagttagcc atttctatgg atttggtttg     1440

gtggacgcag aagctctcgt tgtggaggca aagaagtgga cagcagtgcc atcgcagcac     1500

atgtgtgtgg ccgcctcgga caagagaccc aggagcatcc ccttagtgca ggtgctgcgg     1560

actacggccc tgaccagcgc ctgcgcggag cactcggacc agcgggtggt ctacttggag     1620

cacgtggtgg ttcgcacctc catctcacac ccacgccgag gagacctcca gatctacctg     1680

gtttctccct cgggaaccaa gtctcaactt ttggcaaaga ggttgctgga tctttccaat     1740

gaagggttta caaactggga attcatgact gtccactgct ggggagaaaa ggctgaaggg     1800

cagtggacct tggaaatcca agatctgcca tcccaggtcc gcaacccgga gaagcaaggg     1860

aagttgaaag aatggagcct catactgtat ggcacagcag agcacccgta ccacaccttc     1920

agtgcccatc agtcccgctc gcggatgctg gagctctcag ccccagagct ggagccaccc     1980

aaggctgccc tgtcaccctc ccaggtggaa gttcctgaag atgaggaaga ttacacagct     2040

caatccaccc caggctctgc taatatttta cagaccagtg tgtgccatcc ggagtgtggt     2100

gacaaaggct gtgatggccc caatgcagac cagtgcttga actgcgtcca cttcagcctg     2160

gggagtgtca agaccagcag gaagtgcgtg agtgtgtgcc ccttgggcta ctttggggac     2220

acagcagcaa gacgctgtcg ccggtgccac aaggggtgtg agacctgctc cagcagagct     2280

gcgacgcagt gcctgtcttg ccgccgcggg ttctatcacc accaggagat gaacacctgt     2340

gtgaccctct gtcctgcagg attttatgct gatgaaagtc agaaaaattg ccttaaatgc     2400

cacccaagct gtaaaaagtg cgtggatgaa cctgagaaat gtactgtctg taaagaagga     2460

ttcagccttg cacggggcag ctgcattcct gactgtgagc caggcaccta ctttgactca     2520

gagctgatca gatgtgggga atgccatcac acctgcggaa cctgcgtggg gccaggcaga     2580

gaagagtgca ttcactgtgc gaaaaacttc cacttccacg actggaagtg tgtgccagcc     2640

tgtggtgagg gcttctaccc agaagagatg ccgggcttgc cccacaaagt gtgtcgaagg     2700

tgtgacgaga actgcttgag ctgtgcaggc tccagcagga actgtagcag gtgtaagacg     2760

ggcttcacac agctggggac ctcctgcatc accaaccaca cgtgcagcaa cgctgacgag     2820

acattctgcg agatggtgaa gtccaaccgg ctgtgcgaac ggaagctctt cattcagttc     2880

tgctgccgca cgtgcctcct ggccgggtaa                                      2910


<210>  20
<211>  969
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Pro Pro Arg Ala Pro Pro Ala Pro Gly Pro Arg Pro Pro Pro Arg 
1               5                   10                  15      


Ala Ala Ala Ala Thr Asp Thr Ala Ala Gly Ala Gly Gly Ala Gly Gly 
            20                  25                  30          


Ala Gly Gly Ala Gly Gly Pro Gly Phe Arg Pro Leu Ala Pro Arg Pro 
        35                  40                  45              


Trp Arg Trp Leu Leu Leu Leu Ala Leu Pro Ala Ala Cys Ser Ala Pro 
    50                  55                  60                  


Pro Pro Arg Pro Val Tyr Thr Asn His Trp Ala Val Gln Val Leu Gly 
65                  70                  75                  80  


Gly Pro Ala Glu Ala Asp Arg Val Ala Ala Ala His Gly Tyr Leu Asn 
                85                  90                  95      


Leu Gly Gln Ile Gly Asn Leu Glu Asp Tyr Tyr His Phe Tyr His Ser 
            100                 105                 110         


Lys Thr Phe Lys Arg Ser Thr Leu Ser Ser Arg Gly Pro His Thr Phe 
        115                 120                 125             


Leu Arg Met Asp Pro Gln Val Lys Trp Leu Gln Gln Gln Glu Val Lys 
    130                 135                 140                 


Arg Arg Val Lys Arg Gln Val Arg Ser Asp Pro Gln Ala Leu Tyr Phe 
145                 150                 155                 160 


Asn Asp Pro Ile Trp Ser Asn Met Trp Tyr Leu His Cys Gly Asp Lys 
                165                 170                 175     


Asn Ser Arg Cys Arg Ser Glu Met Asn Val Gln Ala Ala Trp Lys Arg 
            180                 185                 190         


Gly Tyr Thr Gly Lys Asn Val Val Val Thr Ile Leu Asp Asp Gly Ile 
        195                 200                 205             


Glu Arg Asn His Pro Asp Leu Ala Pro Asn Tyr Asp Ser Tyr Ala Ser 
    210                 215                 220                 


Tyr Asp Val Asn Gly Asn Asp Tyr Asp Pro Ser Pro Arg Tyr Asp Ala 
225                 230                 235                 240 


Ser Asn Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala 
                245                 250                 255     


Ser Ala Asn Asn Ser Tyr Cys Ile Val Gly Ile Ala Tyr Asn Ala Lys 
            260                 265                 270         


Ile Gly Gly Ile Arg Met Leu Asp Gly Asp Val Thr Asp Val Val Glu 
        275                 280                 285             


Ala Lys Ser Leu Gly Ile Arg Pro Asn Tyr Ile Asp Ile Tyr Ser Ala 
    290                 295                 300                 


Ser Trp Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Gly Arg 
305                 310                 315                 320 


Leu Ala Lys Gln Ala Phe Glu Tyr Gly Ile Lys Lys Gly Arg Gln Gly 
                325                 330                 335     


Leu Gly Ser Ile Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Glu Gly 
            340                 345                 350         


Asp Tyr Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser 
        355                 360                 365             


Val Ser Ser Ala Thr Glu Asn Gly Tyr Lys Pro Trp Tyr Leu Glu Glu 
    370                 375                 380                 


Cys Ala Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Ala Phe Tyr Glu 
385                 390                 395                 400 


Arg Lys Ile Val Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Gly His 
                405                 410                 415     


Thr Gly Thr Ser Val Ser Ala Pro Met Val Ala Gly Ile Ile Ala Leu 
            420                 425                 430         


Ala Leu Glu Ala Asn Ser Gln Leu Thr Trp Arg Asp Val Gln His Leu 
        435                 440                 445             


Leu Val Lys Thr Ser Arg Pro Ala His Leu Lys Ala Ser Asp Trp Lys 
    450                 455                 460                 


Val Asn Gly Ala Gly His Lys Val Ser His Phe Tyr Gly Phe Gly Leu 
465                 470                 475                 480 


Val Asp Ala Glu Ala Leu Val Val Glu Ala Lys Lys Trp Thr Ala Val 
                485                 490                 495     


Pro Ser Gln His Met Cys Val Ala Ala Ser Asp Lys Arg Pro Arg Ser 
            500                 505                 510         


Ile Pro Leu Val Gln Val Leu Arg Thr Thr Ala Leu Thr Ser Ala Cys 
        515                 520                 525             


Ala Glu His Ser Asp Gln Arg Val Val Tyr Leu Glu His Val Val Val 
    530                 535                 540                 


Arg Thr Ser Ile Ser His Pro Arg Arg Gly Asp Leu Gln Ile Tyr Leu 
545                 550                 555                 560 


Val Ser Pro Ser Gly Thr Lys Ser Gln Leu Leu Ala Lys Arg Leu Leu 
                565                 570                 575     


Asp Leu Ser Asn Glu Gly Phe Thr Asn Trp Glu Phe Met Thr Val His 
            580                 585                 590         


Cys Trp Gly Glu Lys Ala Glu Gly Gln Trp Thr Leu Glu Ile Gln Asp 
        595                 600                 605             


Leu Pro Ser Gln Val Arg Asn Pro Glu Lys Gln Gly Lys Leu Lys Glu 
    610                 615                 620                 


Trp Ser Leu Ile Leu Tyr Gly Thr Ala Glu His Pro Tyr His Thr Phe 
625                 630                 635                 640 


Ser Ala His Gln Ser Arg Ser Arg Met Leu Glu Leu Ser Ala Pro Glu 
                645                 650                 655     


Leu Glu Pro Pro Lys Ala Ala Leu Ser Pro Ser Gln Val Glu Val Pro 
            660                 665                 670         


Glu Asp Glu Glu Asp Tyr Thr Ala Gln Ser Thr Pro Gly Ser Ala Asn 
        675                 680                 685             


Ile Leu Gln Thr Ser Val Cys His Pro Glu Cys Gly Asp Lys Gly Cys 
    690                 695                 700                 


Asp Gly Pro Asn Ala Asp Gln Cys Leu Asn Cys Val His Phe Ser Leu 
705                 710                 715                 720 


Gly Ser Val Lys Thr Ser Arg Lys Cys Val Ser Val Cys Pro Leu Gly 
                725                 730                 735     


Tyr Phe Gly Asp Thr Ala Ala Arg Arg Cys Arg Arg Cys His Lys Gly 
            740                 745                 750         


Cys Glu Thr Cys Ser Ser Arg Ala Ala Thr Gln Cys Leu Ser Cys Arg 
        755                 760                 765             


Arg Gly Phe Tyr His His Gln Glu Met Asn Thr Cys Val Thr Leu Cys 
    770                 775                 780                 


Pro Ala Gly Phe Tyr Ala Asp Glu Ser Gln Lys Asn Cys Leu Lys Cys 
785                 790                 795                 800 


His Pro Ser Cys Lys Lys Cys Val Asp Glu Pro Glu Lys Cys Thr Val 
                805                 810                 815     


Cys Lys Glu Gly Phe Ser Leu Ala Arg Gly Ser Cys Ile Pro Asp Cys 
            820                 825                 830         


Glu Pro Gly Thr Tyr Phe Asp Ser Glu Leu Ile Arg Cys Gly Glu Cys 
        835                 840                 845             


His His Thr Cys Gly Thr Cys Val Gly Pro Gly Arg Glu Glu Cys Ile 
    850                 855                 860                 


His Cys Ala Lys Asn Phe His Phe His Asp Trp Lys Cys Val Pro Ala 
865                 870                 875                 880 


Cys Gly Glu Gly Phe Tyr Pro Glu Glu Met Pro Gly Leu Pro His Lys 
                885                 890                 895     


Val Cys Arg Arg Cys Asp Glu Asn Cys Leu Ser Cys Ala Gly Ser Ser 
            900                 905                 910         


Arg Asn Cys Ser Arg Cys Lys Thr Gly Phe Thr Gln Leu Gly Thr Ser 
        915                 920                 925             


Cys Ile Thr Asn His Thr Cys Ser Asn Ala Asp Glu Thr Phe Cys Glu 
    930                 935                 940                 


Met Val Lys Ser Asn Arg Leu Cys Glu Arg Lys Leu Phe Ile Gln Phe 
945                 950                 955                 960 


Cys Cys Arg Thr Cys Leu Leu Ala Gly 
                965                 


<210>  21
<211>  2358
<212>  DNA
<213>  Homo sapiens

<400>  21
atgccgaagg ggaggcagaa agtgccacac ttggatgccc ccctgggcct gcccacctgc       60

ctctggctgg aattagccgg gctcttctta ctggttccct gggtcatggg cctggcaggg      120

acaggtgggc ctgatggcca gggcacaggg gggccgagct gggctgtgca cctggaaagc      180

ctggaaggtg acggggagga agagactctg gagcagcagg cggatgcctt ggcccaggca      240

gcagggctgg tgaatgctgg acgcatcgga gagcttcagg ggcactacct ctttgtccag      300

cctgctgggc acaggccggc cctggaggtg gaggccatcc ggcagcaggt ggaggctgtg      360

ttggctgggc atgaagctgt gcgctggcac tcagagcaga ggctgctaag gcgggccaag      420

cgcagcgtcc acttcaacga ccccaagtac ccgcagcaat ggcacctgaa taaccgacgg      480

agcccgggca gggacatcaa cgtgacgggt gtgtgggaac gcaatgtgac tgggcgaggg      540

gtgacggtgg tggtagtgga tgacggagtg gaacacacca tccaggacat tgcacccaac      600

tatagccctg agggtagcta tgacctcaac tctaatgacc ctgaccccat gccccacccg      660

gatgtggaga atggcaacca ccatggcacg cgatgtgcag gagagatcgc ggctgtgccc      720

aacaacagct tctgtgccgt gggcgtggcc tacgggagcc gcatcgcagg tatccgggta      780

ctggatggac ctctcacaga cagcatggag gcagtggcgt tcaacaagca ctatcagatc      840

aatgacatct acagctgcag ctggggacca gatgacgatg ggaagacagt ggatggcccc      900

catcagcttg gaaaggctgc cttacaacat ggggtgattg ctggtcgcca gggctttggg      960

agcatctttg tggtagccag tggcaacgga ggccaacaca acgacaactg caactacgat     1020

ggctacgcca actccatcta caccgtcacc ataggagctg tggatgagga gggacgcatg     1080

cctttctatg cagaagaatg tgcctccatg ctggcagtca ccttcagtgg tggggacaag     1140

atgcttcgga gcattgtgac cactgactgg gaccttcaga agggcactgg ctgcactgag     1200

ggccacacag ggacctcagc tgcagcgcct ctggcagctg gcatgatagc cttaatgctg     1260

caggtgcggc cctgcctcac gtggcgtgac gtccagcaca tcattgtctt cacagccacc     1320

cggtatgagg atcgccgtgc agagtgggtc accaacgagg caggcttcag ccatagccac     1380

cagcacggtt tcggcctcct caacgcctgg aggctcgtga atgcagccaa gatctggaca     1440

tctgtccctt acttagcatc ctacgtcagt cccgtgttaa aagaaaacaa ggcgattccg     1500

cagtcccccc gttccctgga ggtcctgtgg aatgtcagca ggatggacct ggagatgtca     1560

gggctgaaga ccctggagca tgtggcagtg acagtctcca tcactcaccc acggcgcggc     1620

agcttggagc tgaagctgtt ctgccccagt ggcatgatgt ccctcatcgg cgccccccgc     1680

agcatggact cggatcccaa cggcttcaat gactggacct tctccactgt gcgatgctgg     1740

ggggagagag cccgagggac ctacaggctt gtcatcaggg atgtcgggga tgagtcattc     1800

caggtcggca tcctccggca atggcagctg accctatatg gctctgtgtg gagtgcagta     1860

gacatcaggg acagacaaag gctgttagag agtgccatga gtggaaaata cctgcacgat     1920

gacttcgccc tgccctgccc accggggctg aaaattcctg aggaagatgg ttacaccatc     1980

acccccaaca ccctcaagac cctggtgctg gtaggctgtt tcaccgtctt ctggactgtt     2040

tactacatgc tggaagtata tttgagccag aggaatgtgg cttccaatca agtttgtagg     2100

agtggaccct gccactggcc ccatcggagc cggaaagcca aggaggaagg gacagagcta     2160

gaatcagtgc cactttgcag cagcaaggat ccagacgaag tggaaacaga gagcaggggc     2220

cctcccacca cctctgacct ccttgcccca gacctgctgg agcaagggga ctggagcctg     2280

tcccagaaca agagcgccct ggactgccct catcagcacc tagacgtacc gcacgggaag     2340

gaggagcaga tctgctag                                                   2358


<210>  22
<211>  785
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Lys Gly Arg Gln Lys Val Pro His Leu Asp Ala Pro Leu Gly 
1               5                   10                  15      


Leu Pro Thr Cys Leu Trp Leu Glu Leu Ala Gly Leu Phe Leu Leu Val 
            20                  25                  30          


Pro Trp Val Met Gly Leu Ala Gly Thr Gly Gly Pro Asp Gly Gln Gly 
        35                  40                  45              


Thr Gly Gly Pro Ser Trp Ala Val His Leu Glu Ser Leu Glu Gly Asp 
    50                  55                  60                  


Gly Glu Glu Glu Thr Leu Glu Gln Gln Ala Asp Ala Leu Ala Gln Ala 
65                  70                  75                  80  


Ala Gly Leu Val Asn Ala Gly Arg Ile Gly Glu Leu Gln Gly His Tyr 
                85                  90                  95      


Leu Phe Val Gln Pro Ala Gly His Arg Pro Ala Leu Glu Val Glu Ala 
            100                 105                 110         


Ile Arg Gln Gln Val Glu Ala Val Leu Ala Gly His Glu Ala Val Arg 
        115                 120                 125             


Trp His Ser Glu Gln Arg Leu Leu Arg Arg Ala Lys Arg Ser Val His 
    130                 135                 140                 


Phe Asn Asp Pro Lys Tyr Pro Gln Gln Trp His Leu Asn Asn Arg Arg 
145                 150                 155                 160 


Ser Pro Gly Arg Asp Ile Asn Val Thr Gly Val Trp Glu Arg Asn Val 
                165                 170                 175     


Thr Gly Arg Gly Val Thr Val Val Val Val Asp Asp Gly Val Glu His 
            180                 185                 190         


Thr Ile Gln Asp Ile Ala Pro Asn Tyr Ser Pro Glu Gly Ser Tyr Asp 
        195                 200                 205             


Leu Asn Ser Asn Asp Pro Asp Pro Met Pro His Pro Asp Val Glu Asn 
    210                 215                 220                 


Gly Asn His His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Val Pro 
225                 230                 235                 240 


Asn Asn Ser Phe Cys Ala Val Gly Val Ala Tyr Gly Ser Arg Ile Ala 
                245                 250                 255     


Gly Ile Arg Val Leu Asp Gly Pro Leu Thr Asp Ser Met Glu Ala Val 
            260                 265                 270         


Ala Phe Asn Lys His Tyr Gln Ile Asn Asp Ile Tyr Ser Cys Ser Trp 
        275                 280                 285             


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro His Gln Leu Gly 
    290                 295                 300                 


Lys Ala Ala Leu Gln His Gly Val Ile Ala Gly Arg Gln Gly Phe Gly 
305                 310                 315                 320 


Ser Ile Phe Val Val Ala Ser Gly Asn Gly Gly Gln His Asn Asp Asn 
                325                 330                 335     


Cys Asn Tyr Asp Gly Tyr Ala Asn Ser Ile Tyr Thr Val Thr Ile Gly 
            340                 345                 350         


Ala Val Asp Glu Glu Gly Arg Met Pro Phe Tyr Ala Glu Glu Cys Ala 
        355                 360                 365             


Ser Met Leu Ala Val Thr Phe Ser Gly Gly Asp Lys Met Leu Arg Ser 
    370                 375                 380                 


Ile Val Thr Thr Asp Trp Asp Leu Gln Lys Gly Thr Gly Cys Thr Glu 
385                 390                 395                 400 


Gly His Thr Gly Thr Ser Ala Ala Ala Pro Leu Ala Ala Gly Met Ile 
                405                 410                 415     


Ala Leu Met Leu Gln Val Arg Pro Cys Leu Thr Trp Arg Asp Val Gln 
            420                 425                 430         


His Ile Ile Val Phe Thr Ala Thr Arg Tyr Glu Asp Arg Arg Ala Glu 
        435                 440                 445             


Trp Val Thr Asn Glu Ala Gly Phe Ser His Ser His Gln His Gly Phe 
    450                 455                 460                 


Gly Leu Leu Asn Ala Trp Arg Leu Val Asn Ala Ala Lys Ile Trp Thr 
465                 470                 475                 480 


Ser Val Pro Tyr Leu Ala Ser Tyr Val Ser Pro Val Leu Lys Glu Asn 
                485                 490                 495     


Lys Ala Ile Pro Gln Ser Pro Arg Ser Leu Glu Val Leu Trp Asn Val 
            500                 505                 510         


Ser Arg Met Asp Leu Glu Met Ser Gly Leu Lys Thr Leu Glu His Val 
        515                 520                 525             


Ala Val Thr Val Ser Ile Thr His Pro Arg Arg Gly Ser Leu Glu Leu 
    530                 535                 540                 


Lys Leu Phe Cys Pro Ser Gly Met Met Ser Leu Ile Gly Ala Pro Arg 
545                 550                 555                 560 


Ser Met Asp Ser Asp Pro Asn Gly Phe Asn Asp Trp Thr Phe Ser Thr 
                565                 570                 575     


Val Arg Cys Trp Gly Glu Arg Ala Arg Gly Thr Tyr Arg Leu Val Ile 
            580                 585                 590         


Arg Asp Val Gly Asp Glu Ser Phe Gln Val Gly Ile Leu Arg Gln Trp 
        595                 600                 605             


Gln Leu Thr Leu Tyr Gly Ser Val Trp Ser Ala Val Asp Ile Arg Asp 
    610                 615                 620                 


Arg Gln Arg Leu Leu Glu Ser Ala Met Ser Gly Lys Tyr Leu His Asp 
625                 630                 635                 640 


Asp Phe Ala Leu Pro Cys Pro Pro Gly Leu Lys Ile Pro Glu Glu Asp 
                645                 650                 655     


Gly Tyr Thr Ile Thr Pro Asn Thr Leu Lys Thr Leu Val Leu Val Gly 
            660                 665                 670         


Cys Phe Thr Val Phe Trp Thr Val Tyr Tyr Met Leu Glu Val Tyr Leu 
        675                 680                 685             


Ser Gln Arg Asn Val Ala Ser Asn Gln Val Cys Arg Ser Gly Pro Cys 
    690                 695                 700                 


His Trp Pro His Arg Ser Arg Lys Ala Lys Glu Glu Gly Thr Glu Leu 
705                 710                 715                 720 


Glu Ser Val Pro Leu Cys Ser Ser Lys Asp Pro Asp Glu Val Glu Thr 
                725                 730                 735     


Glu Ser Arg Gly Pro Pro Thr Thr Ser Asp Leu Leu Ala Pro Asp Leu 
            740                 745                 750         


Leu Glu Gln Gly Asp Trp Ser Leu Ser Gln Asn Lys Ser Ala Leu Asp 
        755                 760                 765             


Cys Pro His Gln His Leu Asp Val Pro His Gly Lys Glu Glu Gln Ile 
    770                 775                 780                 


Cys 
785 


<210>  23
<211>  3159
<212>  DNA
<213>  Homo sapiens

<400>  23
atgaagcttg tcaacatctg gctgcttctg ctcgtggttt tgctctgtgg gaagaaacat       60

ctgggcgaca gactggaaaa gaaatctttt gaaaaggccc catgccctgg ctgttcccac      120

ctgactttga aggtggaatt ctcatcaaca gttgtggaat atgaatatat tgtggctttc      180

aatggatact ttacagccaa agctagaaat tcatttattt caagtgccct gaagagcagt      240

gaagtagaca attggagaat tatacctcga aacaatccat ccagtgacta ccctagtgat      300

tttgaggtga ttcagataaa agaaaaacag aaagcggggc tgctaacact tgaagatcat      360

ccaaacatca aacgggtcac gccccaacga aaagtctttc gttccctcaa gtatgctgaa      420

tctgacccca cagtaccctg caatgaaacc cggtggagcc agaagtggca atcatcacgt      480

cccctgcgaa gagccagcct ctccctgggc tctggcttct ggcatgctac gggaaggcat      540

tcgagcagac ggctgctgag agccatcccg cgccaggttg cccagacact gcaggcagat      600

gtgctctggc agatgggata tacaggtgct aatgtaagag ttgctgtttt tgacactggg      660

ctgagcgaga agcatcccca cttcaaaaat gtgaaggaga gaaccaactg gaccaacgag      720

cgaacgctgg acgatgggtt gggccatggc acattcgtgg caggtgtgat agccagcatg      780

agggagtgcc aaggatttgc tccagatgca gaacttcaca ttttcagggt ctttaccaat      840

aatcaggtat cttacacatc ttggtttttg gacgccttca actatgccat tttaaagaag      900

atcgacgtgt taaacctcag catcggcggc ccggacttca tggatcatcc gtttgttgac      960

aaggtgtggg aattaacagc taacaatgta atcatggttt ctgctattgg caatgacgga     1020

cctctttatg gcactctgaa taaccctgct gatcaaatgg atgtgattgg agtaggcggc     1080

attgactttg aagataacat cgcccgcttt tcttcaaggg gaatgactac ctgggagcta     1140

ccaggaggct acggtcgcat gaaacctgac attgtcacct atggtgctgg cgtgcggggt     1200

tctggcgtga aaggggggtg ccgggccctc tcagggacca gtgttgcttc tccagtggtt     1260

gcaggtgctg tcaccttgtt agtgagcaca gtccagaagc gtgagctggt gaatcccgcc     1320

agtatgaagc aggccctgat cgcgtcagcc cggaggctcc ccggggtcaa catgtttgag     1380

caaggccacg gcaagctcga tctgctcaga gcctatcaga tcctcaacag ctacaagcca     1440

caggcaagtt tgagccccag ctacatagat ctgactgagt gtccctacat gtggccctac     1500

tgctcccagc ccatctacta tggaggaatg ccgacagttg ttaatgtcac catcctcaac     1560

ggcatgggag tcacaggaag aattgtagat aagcctgact ggcagcccta tttgccacag     1620

aacggagaca acattgaagt tgccttctcc tactcctcgg tcttatggcc ttggtcgggc     1680

tacctggcca tctccatttc tgtgaccaag aaagcggctt cctgggaagg cattgctcag     1740

ggccatgtca tgatcactgt ggcttcccca gcagagacag agtcaaaaaa tggtgcagaa     1800

cagacttcaa cagtaaagct ccccattaag gtgaagataa ttcctactcc cccgcgaagc     1860

aagagagttc tctgggatca gtaccacaac ctccgctatc cacctggcta tttccccagg     1920

gataatttaa ggatgaagaa tgacccttta gactggaatg gtgatcacat ccacaccaat     1980

ttcagggata tgtaccagca tctgagaagc atgggctact ttgtagaggt cctcggggcc     2040

cccttcacgt gttttgatgc cagtcagtat ggcactttgc tgatggtgga cagtgaggag     2100

gagtacttcc ctgaagagat cgccaagctc cggagggacg tggacaacgg cctctcgctc     2160

gtcatcttca gtgactggta caacacttct gttatgagaa aagtgaagtt ttatgatgaa     2220

aacacaaggc agtggtggat gccggatacc ggaggagcta acatcccagc tctgaatgag     2280

ctgctgtctg tgtggaacat ggggttcagc gatggcctgt atgaagggga gttcaccctg     2340

gccaaccatg acatgtatta tgcgtcaggg tgcagcatcg cgaagtttcc agaagatggc     2400

gtcgtgataa cacagacttt caaggaccaa ggattggagg ttttaaagca ggaaacagca     2460

gttgttgaaa acgtccccat tttgggactt tatcagattc cagctgaggg tggaggccgg     2520

attgtactgt atggggactc caattgcttg gatgacagtc accgacagaa ggactgcttt     2580

tggcttctgg atgccctcct ccagtacaca tcgtatgggg tgacaccgcc tagcctcagt     2640

cactctggga accgccagcg ccctcccagt ggagcaggct cagtcactcc agagaggatg     2700

gaaggaaacc atcttcatcg gtactccaag gttctggagg cccatttggg agacccaaaa     2760

cctcggcctc taccagcctg tccacgcttg tcttgggcca agccacagcc tttaaacgag     2820

acggcgccca gtaacctttg gaaacatcag aagctactct ccattgacct ggacaaggtg     2880

gtgttaccca actttcgatc gaatcgccct caagtgaggc ccttgtcccc tggagagagc     2940

ggcgcctggg acattcctgg agggatcatg cctggccgct acaaccagga ggtgggccag     3000

accattcctg tctttgcctt cctgggagcc atggtggtcc tggccttctt tgtggtacaa     3060

atcaacaagg ccaagagcag gccgaagcgg aggaagccca gggtgaagcg cccgcagctc     3120

atgcagcagg ttcacccgcc aaagacccct tcggtgtga                            3159


<210>  24
<211>  3159
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Thr Gly Ala Ala Gly Cys Thr Thr Gly Thr Cys Ala Ala Cys Ala 
1               5                   10                  15      


Thr Cys Thr Gly Gly Cys Thr Gly Cys Thr Thr Cys Thr Gly Cys Thr 
            20                  25                  30          


Cys Gly Thr Gly Gly Thr Thr Thr Thr Gly Cys Thr Cys Thr Gly Thr 
        35                  40                  45              


Gly Gly Gly Ala Ala Gly Ala Ala Ala Cys Ala Thr Cys Thr Gly Gly 
    50                  55                  60                  


Gly Cys Gly Ala Cys Ala Gly Ala Cys Thr Gly Gly Ala Ala Ala Ala 
65                  70                  75                  80  


Gly Ala Ala Ala Thr Cys Thr Thr Thr Thr Gly Ala Ala Ala Ala Gly 
                85                  90                  95      


Gly Cys Cys Cys Cys Ala Thr Gly Cys Cys Cys Thr Gly Gly Cys Thr 
            100                 105                 110         


Gly Thr Thr Cys Cys Cys Ala Cys Cys Thr Gly Ala Cys Thr Thr Thr 
        115                 120                 125             


Gly Ala Ala Gly Gly Thr Gly Gly Ala Ala Thr Thr Cys Thr Cys Ala 
    130                 135                 140                 


Thr Cys Ala Ala Cys Ala Gly Thr Thr Gly Thr Gly Gly Ala Ala Thr 
145                 150                 155                 160 


Ala Thr Gly Ala Ala Thr Ala Thr Ala Thr Thr Gly Thr Gly Gly Cys 
                165                 170                 175     


Thr Thr Thr Cys Ala Ala Thr Gly Gly Ala Thr Ala Cys Thr Thr Thr 
            180                 185                 190         


Ala Cys Ala Gly Cys Cys Ala Ala Ala Gly Cys Thr Ala Gly Ala Ala 
        195                 200                 205             


Ala Thr Thr Cys Ala Thr Thr Thr Ala Thr Thr Thr Cys Ala Ala Gly 
    210                 215                 220                 


Thr Gly Cys Cys Cys Thr Gly Ala Ala Gly Ala Gly Cys Ala Gly Thr 
225                 230                 235                 240 


Gly Ala Ala Gly Thr Ala Gly Ala Cys Ala Ala Thr Thr Gly Gly Ala 
                245                 250                 255     


Gly Ala Ala Thr Thr Ala Thr Ala Cys Cys Thr Cys Gly Ala Ala Ala 
            260                 265                 270         


Cys Ala Ala Thr Cys Cys Ala Thr Cys Cys Ala Gly Thr Gly Ala Cys 
        275                 280                 285             


Thr Ala Cys Cys Cys Thr Ala Gly Thr Gly Ala Thr Thr Thr Thr Gly 
    290                 295                 300                 


Ala Gly Gly Thr Gly Ala Thr Thr Cys Ala Gly Ala Thr Ala Ala Ala 
305                 310                 315                 320 


Ala Gly Ala Ala Ala Ala Ala Cys Ala Gly Ala Ala Ala Gly Cys Gly 
                325                 330                 335     


Gly Gly Gly Cys Thr Gly Cys Thr Ala Ala Cys Ala Cys Thr Thr Gly 
            340                 345                 350         


Ala Ala Gly Ala Thr Cys Ala Thr Cys Cys Ala Ala Ala Cys Ala Thr 
        355                 360                 365             


Cys Ala Ala Ala Cys Gly Gly Gly Thr Cys Ala Cys Gly Cys Cys Cys 
    370                 375                 380                 


Cys Ala Ala Cys Gly Ala Ala Ala Ala Gly Thr Cys Thr Thr Thr Cys 
385                 390                 395                 400 


Gly Thr Thr Cys Cys Cys Thr Cys Ala Ala Gly Thr Ala Thr Gly Cys 
                405                 410                 415     


Thr Gly Ala Ala Thr Cys Thr Gly Ala Cys Cys Cys Cys Ala Cys Ala 
            420                 425                 430         


Gly Thr Ala Cys Cys Cys Thr Gly Cys Ala Ala Thr Gly Ala Ala Ala 
        435                 440                 445             


Cys Cys Cys Gly Gly Thr Gly Gly Ala Gly Cys Cys Ala Gly Ala Ala 
    450                 455                 460                 


Gly Thr Gly Gly Cys Ala Ala Thr Cys Ala Thr Cys Ala Cys Gly Thr 
465                 470                 475                 480 


Cys Cys Cys Cys Thr Gly Cys Gly Ala Ala Gly Ala Gly Cys Cys Ala 
                485                 490                 495     


Gly Cys Cys Thr Cys Thr Cys Cys Cys Thr Gly Gly Gly Cys Thr Cys 
            500                 505                 510         


Thr Gly Gly Cys Thr Thr Cys Thr Gly Gly Cys Ala Thr Gly Cys Thr 
        515                 520                 525             


Ala Cys Gly Gly Gly Ala Ala Gly Gly Cys Ala Thr Thr Cys Gly Ala 
    530                 535                 540                 


Gly Cys Ala Gly Ala Cys Gly Gly Cys Thr Gly Cys Thr Gly Ala Gly 
545                 550                 555                 560 


Ala Gly Cys Cys Ala Thr Cys Cys Cys Gly Cys Gly Cys Cys Ala Gly 
                565                 570                 575     


Gly Thr Thr Gly Cys Cys Cys Ala Gly Ala Cys Ala Cys Thr Gly Cys 
            580                 585                 590         


Ala Gly Gly Cys Ala Gly Ala Thr Gly Thr Gly Cys Thr Cys Thr Gly 
        595                 600                 605             


Gly Cys Ala Gly Ala Thr Gly Gly Gly Ala Thr Ala Thr Ala Cys Ala 
    610                 615                 620                 


Gly Gly Thr Gly Cys Thr Ala Ala Thr Gly Thr Ala Ala Gly Ala Gly 
625                 630                 635                 640 


Thr Thr Gly Cys Thr Gly Thr Thr Thr Thr Thr Gly Ala Cys Ala Cys 
                645                 650                 655     


Thr Gly Gly Gly Cys Thr Gly Ala Gly Cys Gly Ala Gly Ala Ala Gly 
            660                 665                 670         


Cys Ala Thr Cys Cys Cys Cys Ala Cys Thr Thr Cys Ala Ala Ala Ala 
        675                 680                 685             


Ala Thr Gly Thr Gly Ala Ala Gly Gly Ala Gly Ala Gly Ala Ala Cys 
    690                 695                 700                 


Cys Ala Ala Cys Thr Gly Gly Ala Cys Cys Ala Ala Cys Gly Ala Gly 
705                 710                 715                 720 


Cys Gly Ala Ala Cys Gly Cys Thr Gly Gly Ala Cys Gly Ala Thr Gly 
                725                 730                 735     


Gly Gly Thr Thr Gly Gly Gly Cys Cys Ala Thr Gly Gly Cys Ala Cys 
            740                 745                 750         


Ala Thr Thr Cys Gly Thr Gly Gly Cys Ala Gly Gly Thr Gly Thr Gly 
        755                 760                 765             


Ala Thr Ala Gly Cys Cys Ala Gly Cys Ala Thr Gly Ala Gly Gly Gly 
    770                 775                 780                 


Ala Gly Thr Gly Cys Cys Ala Ala Gly Gly Ala Thr Thr Thr Gly Cys 
785                 790                 795                 800 


Thr Cys Cys Ala Gly Ala Thr Gly Cys Ala Gly Ala Ala Cys Thr Thr 
                805                 810                 815     


Cys Ala Cys Ala Thr Thr Thr Thr Cys Ala Gly Gly Gly Thr Cys Thr 
            820                 825                 830         


Thr Thr Ala Cys Cys Ala Ala Thr Ala Ala Thr Cys Ala Gly Gly Thr 
        835                 840                 845             


Ala Thr Cys Thr Thr Ala Cys Ala Cys Ala Thr Cys Thr Thr Gly Gly 
    850                 855                 860                 


Thr Thr Thr Thr Thr Gly Gly Ala Cys Gly Cys Cys Thr Thr Cys Ala 
865                 870                 875                 880 


Ala Cys Thr Ala Thr Gly Cys Cys Ala Thr Thr Thr Thr Ala Ala Ala 
                885                 890                 895     


Gly Ala Ala Gly Ala Thr Cys Gly Ala Cys Gly Thr Gly Thr Thr Ala 
            900                 905                 910         


Ala Ala Cys Cys Thr Cys Ala Gly Cys Ala Thr Cys Gly Gly Cys Gly 
        915                 920                 925             


Gly Cys Cys Cys Gly Gly Ala Cys Thr Thr Cys Ala Thr Gly Gly Ala 
    930                 935                 940                 


Thr Cys Ala Thr Cys Cys Gly Thr Thr Thr Gly Thr Thr Gly Ala Cys 
945                 950                 955                 960 


Ala Ala Gly Gly Thr Gly Thr Gly Gly Gly Ala Ala Thr Thr Ala Ala 
                965                 970                 975     


Cys Ala Gly Cys Thr Ala Ala Cys Ala Ala Thr Gly Thr Ala Ala Thr 
            980                 985                 990         


Cys Ala Thr Gly Gly Thr Thr Thr  Cys Thr Gly Cys Thr  Ala Thr Thr 
        995                 1000                 1005             


Gly Gly  Cys Ala Ala Thr Gly  Ala Cys Gly Gly Ala  Cys Cys Thr 
    1010                 1015                 1020             


Cys Thr  Thr Thr Ala Thr Gly  Gly Cys Ala Cys Thr  Cys Thr Gly 
    1025                 1030                 1035             


Ala Ala  Thr Ala Ala Cys Cys  Cys Thr Gly Cys Thr  Gly Ala Thr 
    1040                 1045                 1050             


Cys Ala  Ala Ala Thr Gly Gly  Ala Thr Gly Thr Gly  Ala Thr Thr 
    1055                 1060                 1065             


Gly Gly  Ala Gly Thr Ala Gly  Gly Cys Gly Gly Cys  Ala Thr Thr 
    1070                 1075                 1080             


Gly Ala  Cys Thr Thr Thr Gly  Ala Ala Gly Ala Thr  Ala Ala Cys 
    1085                 1090                 1095             


Ala Thr  Cys Gly Cys Cys Cys  Gly Cys Thr Thr Thr  Thr Cys Thr 
    1100                 1105                 1110             


Thr Cys  Ala Ala Gly Gly Gly  Gly Ala Ala Thr Gly  Ala Cys Thr 
    1115                 1120                 1125             


Ala Cys  Cys Thr Gly Gly Gly  Ala Gly Cys Thr Ala  Cys Cys Ala 
    1130                 1135                 1140             


Gly Gly  Ala Gly Gly Cys Thr  Ala Cys Gly Gly Thr  Cys Gly Cys 
    1145                 1150                 1155             


Ala Thr  Gly Ala Ala Ala Cys  Cys Thr Gly Ala Cys  Ala Thr Thr 
    1160                 1165                 1170             


Gly Thr  Cys Ala Cys Cys Thr  Ala Thr Gly Gly Thr  Gly Cys Thr 
    1175                 1180                 1185             


Gly Gly  Cys Gly Thr Gly Cys  Gly Gly Gly Gly Thr  Thr Cys Thr 
    1190                 1195                 1200             


Gly Gly  Cys Gly Thr Gly Ala  Ala Ala Gly Gly Gly  Gly Gly Gly 
    1205                 1210                 1215             


Thr Gly  Cys Cys Gly Gly Gly  Cys Cys Cys Thr Cys  Thr Cys Ala 
    1220                 1225                 1230             


Gly Gly  Gly Ala Cys Cys Ala  Gly Thr Gly Thr Thr  Gly Cys Thr 
    1235                 1240                 1245             


Thr Cys  Thr Cys Cys Ala Gly  Thr Gly Gly Thr Thr  Gly Cys Ala 
    1250                 1255                 1260             


Gly Gly  Thr Gly Cys Thr Gly  Thr Cys Ala Cys Cys  Thr Thr Gly 
    1265                 1270                 1275             


Thr Thr  Ala Gly Thr Gly Ala  Gly Cys Ala Cys Ala  Gly Thr Cys 
    1280                 1285                 1290             


Cys Ala  Gly Ala Ala Gly Cys  Gly Thr Gly Ala Gly  Cys Thr Gly 
    1295                 1300                 1305             


Gly Thr  Gly Ala Ala Thr Cys  Cys Cys Gly Cys Cys  Ala Gly Thr 
    1310                 1315                 1320             


Ala Thr  Gly Ala Ala Gly Cys  Ala Gly Gly Cys Cys  Cys Thr Gly 
    1325                 1330                 1335             


Ala Thr  Cys Gly Cys Gly Thr  Cys Ala Gly Cys Cys  Cys Gly Gly 
    1340                 1345                 1350             


Ala Gly  Gly Cys Thr Cys Cys  Cys Cys Gly Gly Gly  Gly Thr Cys 
    1355                 1360                 1365             


Ala Ala  Cys Ala Thr Gly Thr  Thr Thr Gly Ala Gly  Cys Ala Ala 
    1370                 1375                 1380             


Gly Gly  Cys Cys Ala Cys Gly  Gly Cys Ala Ala Gly  Cys Thr Cys 
    1385                 1390                 1395             


Gly Ala  Thr Cys Thr Gly Cys  Thr Cys Ala Gly Ala  Gly Cys Cys 
    1400                 1405                 1410             


Thr Ala  Thr Cys Ala Gly Ala  Thr Cys Cys Thr Cys  Ala Ala Cys 
    1415                 1420                 1425             


Ala Gly  Cys Thr Ala Cys Ala  Ala Gly Cys Cys Ala  Cys Ala Gly 
    1430                 1435                 1440             


Gly Cys  Ala Ala Gly Thr Thr  Thr Gly Ala Gly Cys  Cys Cys Cys 
    1445                 1450                 1455             


Ala Gly  Cys Thr Ala Cys Ala  Thr Ala Gly Ala Thr  Cys Thr Gly 
    1460                 1465                 1470             


Ala Cys  Thr Gly Ala Gly Thr  Gly Thr Cys Cys Cys  Thr Ala Cys 
    1475                 1480                 1485             


Ala Thr  Gly Thr Gly Gly Cys  Cys Cys Thr Ala Cys  Thr Gly Cys 
    1490                 1495                 1500             


Thr Cys  Cys Cys Ala Gly Cys  Cys Cys Ala Thr Cys  Thr Ala Cys 
    1505                 1510                 1515             


Thr Ala  Thr Gly Gly Ala Gly  Gly Ala Ala Thr Gly  Cys Cys Gly 
    1520                 1525                 1530             


Ala Cys  Ala Gly Thr Thr Gly  Thr Thr Ala Ala Thr  Gly Thr Cys 
    1535                 1540                 1545             


Ala Cys  Cys Ala Thr Cys Cys  Thr Cys Ala Ala Cys  Gly Gly Cys 
    1550                 1555                 1560             


Ala Thr  Gly Gly Gly Ala Gly  Thr Cys Ala Cys Ala  Gly Gly Ala 
    1565                 1570                 1575             


Ala Gly  Ala Ala Thr Thr Gly  Thr Ala Gly Ala Thr  Ala Ala Gly 
    1580                 1585                 1590             


Cys Cys  Thr Gly Ala Cys Thr  Gly Gly Cys Ala Gly  Cys Cys Cys 
    1595                 1600                 1605             


Thr Ala  Thr Thr Thr Gly Cys  Cys Ala Cys Ala Gly  Ala Ala Cys 
    1610                 1615                 1620             


Gly Gly  Ala Gly Ala Cys Ala  Ala Cys Ala Thr Thr  Gly Ala Ala 
    1625                 1630                 1635             


Gly Thr  Thr Gly Cys Cys Thr  Thr Cys Thr Cys Cys  Thr Ala Cys 
    1640                 1645                 1650             


Thr Cys  Cys Thr Cys Gly Gly  Thr Cys Thr Thr Ala  Thr Gly Gly 
    1655                 1660                 1665             


Cys Cys  Thr Thr Gly Gly Thr  Cys Gly Gly Gly Cys  Thr Ala Cys 
    1670                 1675                 1680             


Cys Thr  Gly Gly Cys Cys Ala  Thr Cys Thr Cys Cys  Ala Thr Thr 
    1685                 1690                 1695             


Thr Cys  Thr Gly Thr Gly Ala  Cys Cys Ala Ala Gly  Ala Ala Ala 
    1700                 1705                 1710             


Gly Cys  Gly Gly Cys Thr Thr  Cys Cys Thr Gly Gly  Gly Ala Ala 
    1715                 1720                 1725             


Gly Gly  Cys Ala Thr Thr Gly  Cys Thr Cys Ala Gly  Gly Gly Cys 
    1730                 1735                 1740             


Cys Ala  Thr Gly Thr Cys Ala  Thr Gly Ala Thr Cys  Ala Cys Thr 
    1745                 1750                 1755             


Gly Thr  Gly Gly Cys Thr Thr  Cys Cys Cys Cys Ala  Gly Cys Ala 
    1760                 1765                 1770             


Gly Ala  Gly Ala Cys Ala Gly  Ala Gly Thr Cys Ala  Ala Ala Ala 
    1775                 1780                 1785             


Ala Ala  Thr Gly Gly Thr Gly  Cys Ala Gly Ala Ala  Cys Ala Gly 
    1790                 1795                 1800             


Ala Cys  Thr Thr Cys Ala Ala  Cys Ala Gly Thr Ala  Ala Ala Gly 
    1805                 1810                 1815             


Cys Thr  Cys Cys Cys Cys Ala  Thr Thr Ala Ala Gly  Gly Thr Gly 
    1820                 1825                 1830             


Ala Ala  Gly Ala Thr Ala Ala  Thr Thr Cys Cys Thr  Ala Cys Thr 
    1835                 1840                 1845             


Cys Cys  Cys Cys Cys Gly Cys  Gly Ala Ala Gly Cys  Ala Ala Gly 
    1850                 1855                 1860             


Ala Gly  Ala Gly Thr Thr Cys  Thr Cys Thr Gly Gly  Gly Ala Thr 
    1865                 1870                 1875             


Cys Ala  Gly Thr Ala Cys Cys  Ala Cys Ala Ala Cys  Cys Thr Cys 
    1880                 1885                 1890             


Cys Gly  Cys Thr Ala Thr Cys  Cys Ala Cys Cys Thr  Gly Gly Cys 
    1895                 1900                 1905             


Thr Ala  Thr Thr Thr Cys Cys  Cys Cys Ala Gly Gly  Gly Ala Thr 
    1910                 1915                 1920             


Ala Ala  Thr Thr Thr Ala Ala  Gly Gly Ala Thr Gly  Ala Ala Gly 
    1925                 1930                 1935             


Ala Ala  Thr Gly Ala Cys Cys  Cys Thr Thr Thr Ala  Gly Ala Cys 
    1940                 1945                 1950             


Thr Gly  Gly Ala Ala Thr Gly  Gly Thr Gly Ala Thr  Cys Ala Cys 
    1955                 1960                 1965             


Ala Thr  Cys Cys Ala Cys Ala  Cys Cys Ala Ala Thr  Thr Thr Cys 
    1970                 1975                 1980             


Ala Gly  Gly Gly Ala Thr Ala  Thr Gly Thr Ala Cys  Cys Ala Gly 
    1985                 1990                 1995             


Cys Ala  Thr Cys Thr Gly Ala  Gly Ala Ala Gly Cys  Ala Thr Gly 
    2000                 2005                 2010             


Gly Gly  Cys Thr Ala Cys Thr  Thr Thr Gly Thr Ala  Gly Ala Gly 
    2015                 2020                 2025             


Gly Thr  Cys Cys Thr Cys Gly  Gly Gly Gly Cys Cys  Cys Cys Cys 
    2030                 2035                 2040             


Thr Thr  Cys Ala Cys Gly Thr  Gly Thr Thr Thr Thr  Gly Ala Thr 
    2045                 2050                 2055             


Gly Cys  Cys Ala Gly Thr Cys  Ala Gly Thr Ala Thr  Gly Gly Cys 
    2060                 2065                 2070             


Ala Cys  Thr Thr Thr Gly Cys  Thr Gly Ala Thr Gly  Gly Thr Gly 
    2075                 2080                 2085             


Gly Ala  Cys Ala Gly Thr Gly  Ala Gly Gly Ala Gly  Gly Ala Gly 
    2090                 2095                 2100             


Thr Ala  Cys Thr Thr Cys Cys  Cys Thr Gly Ala Ala  Gly Ala Gly 
    2105                 2110                 2115             


Ala Thr  Cys Gly Cys Cys Ala  Ala Gly Cys Thr Cys  Cys Gly Gly 
    2120                 2125                 2130             


Ala Gly  Gly Gly Ala Cys Gly  Thr Gly Gly Ala Cys  Ala Ala Cys 
    2135                 2140                 2145             


Gly Gly  Cys Cys Thr Cys Thr  Cys Gly Cys Thr Cys  Gly Thr Cys 
    2150                 2155                 2160             


Ala Thr  Cys Thr Thr Cys Ala  Gly Thr Gly Ala Cys  Thr Gly Gly 
    2165                 2170                 2175             


Thr Ala  Cys Ala Ala Cys Ala  Cys Thr Thr Cys Thr  Gly Thr Thr 
    2180                 2185                 2190             


Ala Thr  Gly Ala Gly Ala Ala  Ala Ala Gly Thr Gly  Ala Ala Gly 
    2195                 2200                 2205             


Thr Thr  Thr Thr Ala Thr Gly  Ala Thr Gly Ala Ala  Ala Ala Cys 
    2210                 2215                 2220             


Ala Cys  Ala Ala Gly Gly Cys  Ala Gly Thr Gly Gly  Thr Gly Gly 
    2225                 2230                 2235             


Ala Thr  Gly Cys Cys Gly Gly  Ala Thr Ala Cys Cys  Gly Gly Ala 
    2240                 2245                 2250             


Gly Gly  Ala Gly Cys Thr Ala  Ala Cys Ala Thr Cys  Cys Cys Ala 
    2255                 2260                 2265             


Gly Cys  Thr Cys Thr Gly Ala  Ala Thr Gly Ala Gly  Cys Thr Gly 
    2270                 2275                 2280             


Cys Thr  Gly Thr Cys Thr Gly  Thr Gly Thr Gly Gly  Ala Ala Cys 
    2285                 2290                 2295             


Ala Thr  Gly Gly Gly Gly Thr  Thr Cys Ala Gly Cys  Gly Ala Thr 
    2300                 2305                 2310             


Gly Gly  Cys Cys Thr Gly Thr  Ala Thr Gly Ala Ala  Gly Gly Gly 
    2315                 2320                 2325             


Gly Ala  Gly Thr Thr Cys Ala  Cys Cys Cys Thr Gly  Gly Cys Cys 
    2330                 2335                 2340             


Ala Ala  Cys Cys Ala Thr Gly  Ala Cys Ala Thr Gly  Thr Ala Thr 
    2345                 2350                 2355             


Thr Ala  Thr Gly Cys Gly Thr  Cys Ala Gly Gly Gly  Thr Gly Cys 
    2360                 2365                 2370             


Ala Gly  Cys Ala Thr Cys Gly  Cys Gly Ala Ala Gly  Thr Thr Thr 
    2375                 2380                 2385             


Cys Cys  Ala Gly Ala Ala Gly  Ala Thr Gly Gly Cys  Gly Thr Cys 
    2390                 2395                 2400             


Gly Thr  Gly Ala Thr Ala Ala  Cys Ala Cys Ala Gly  Ala Cys Thr 
    2405                 2410                 2415             


Thr Thr  Cys Ala Ala Gly Gly  Ala Cys Cys Ala Ala  Gly Gly Ala 
    2420                 2425                 2430             


Thr Thr  Gly Gly Ala Gly Gly  Thr Thr Thr Thr Ala  Ala Ala Gly 
    2435                 2440                 2445             


Cys Ala  Gly Gly Ala Ala Ala  Cys Ala Gly Cys Ala  Gly Thr Thr 
    2450                 2455                 2460             


Gly Thr  Thr Gly Ala Ala Ala  Ala Cys Gly Thr Cys  Cys Cys Cys 
    2465                 2470                 2475             


Ala Thr  Thr Thr Thr Gly Gly  Gly Ala Cys Thr Thr  Thr Ala Thr 
    2480                 2485                 2490             


Cys Ala  Gly Ala Thr Thr Cys  Cys Ala Gly Cys Thr  Gly Ala Gly 
    2495                 2500                 2505             


Gly Gly  Thr Gly Gly Ala Gly  Gly Cys Cys Gly Gly  Ala Thr Thr 
    2510                 2515                 2520             


Gly Thr  Ala Cys Thr Gly Thr  Ala Thr Gly Gly Gly  Gly Ala Cys 
    2525                 2530                 2535             


Thr Cys  Cys Ala Ala Thr Thr  Gly Cys Thr Thr Gly  Gly Ala Thr 
    2540                 2545                 2550             


Gly Ala  Cys Ala Gly Thr Cys  Ala Cys Cys Gly Ala  Cys Ala Gly 
    2555                 2560                 2565             


Ala Ala  Gly Gly Ala Cys Thr  Gly Cys Thr Thr Thr  Thr Gly Gly 
    2570                 2575                 2580             


Cys Thr  Thr Cys Thr Gly Gly  Ala Thr Gly Cys Cys  Cys Thr Cys 
    2585                 2590                 2595             


Cys Thr  Cys Cys Ala Gly Thr  Ala Cys Ala Cys Ala  Thr Cys Gly 
    2600                 2605                 2610             


Thr Ala  Thr Gly Gly Gly Gly  Thr Gly Ala Cys Ala  Cys Cys Gly 
    2615                 2620                 2625             


Cys Cys  Thr Ala Gly Cys Cys  Thr Cys Ala Gly Thr  Cys Ala Cys 
    2630                 2635                 2640             


Thr Cys  Thr Gly Gly Gly Ala  Ala Cys Cys Gly Cys  Cys Ala Gly 
    2645                 2650                 2655             


Cys Gly  Cys Cys Cys Thr Cys  Cys Cys Ala Gly Thr  Gly Gly Ala 
    2660                 2665                 2670             


Gly Cys  Ala Gly Gly Cys Thr  Cys Ala Gly Thr Cys  Ala Cys Thr 
    2675                 2680                 2685             


Cys Cys  Ala Gly Ala Gly Ala  Gly Gly Ala Thr Gly  Gly Ala Ala 
    2690                 2695                 2700             


Gly Gly  Ala Ala Ala Cys Cys  Ala Thr Cys Thr Thr  Cys Ala Thr 
    2705                 2710                 2715             


Cys Gly  Gly Thr Ala Cys Thr  Cys Cys Ala Ala Gly  Gly Thr Thr 
    2720                 2725                 2730             


Cys Thr  Gly Gly Ala Gly Gly  Cys Cys Cys Ala Thr  Thr Thr Gly 
    2735                 2740                 2745             


Gly Gly  Ala Gly Ala Cys Cys  Cys Ala Ala Ala Ala  Cys Cys Thr 
    2750                 2755                 2760             


Cys Gly  Gly Cys Cys Thr Cys  Thr Ala Cys Cys Ala  Gly Cys Cys 
    2765                 2770                 2775             


Thr Gly  Thr Cys Cys Ala Cys  Gly Cys Thr Thr Gly  Thr Cys Thr 
    2780                 2785                 2790             


Thr Gly  Gly Gly Cys Cys Ala  Ala Gly Cys Cys Ala  Cys Ala Gly 
    2795                 2800                 2805             


Cys Cys  Thr Thr Thr Ala Ala  Ala Cys Gly Ala Gly  Ala Cys Gly 
    2810                 2815                 2820             


Gly Cys  Gly Cys Cys Cys Ala  Gly Thr Ala Ala Cys  Cys Thr Thr 
    2825                 2830                 2835             


Thr Gly  Gly Ala Ala Ala Cys  Ala Thr Cys Ala Gly  Ala Ala Gly 
    2840                 2845                 2850             


Cys Thr  Ala Cys Thr Cys Thr  Cys Cys Ala Thr Thr  Gly Ala Cys 
    2855                 2860                 2865             


Cys Thr  Gly Gly Ala Cys Ala  Ala Gly Gly Thr Gly  Gly Thr Gly 
    2870                 2875                 2880             


Thr Thr  Ala Cys Cys Cys Ala  Ala Cys Thr Thr Thr  Cys Gly Ala 
    2885                 2890                 2895             


Thr Cys  Gly Ala Ala Thr Cys  Gly Cys Cys Cys Thr  Cys Ala Ala 
    2900                 2905                 2910             


Gly Thr  Gly Ala Gly Gly Cys  Cys Cys Thr Thr Gly  Thr Cys Cys 
    2915                 2920                 2925             


Cys Cys  Thr Gly Gly Ala Gly  Ala Gly Ala Gly Cys  Gly Gly Cys 
    2930                 2935                 2940             


Gly Cys  Cys Thr Gly Gly Gly  Ala Cys Ala Thr Thr  Cys Cys Thr 
    2945                 2950                 2955             


Gly Gly  Ala Gly Gly Gly Ala  Thr Cys Ala Thr Gly  Cys Cys Thr 
    2960                 2965                 2970             


Gly Gly  Cys Cys Gly Cys Thr  Ala Cys Ala Ala Cys  Cys Ala Gly 
    2975                 2980                 2985             


Gly Ala  Gly Gly Thr Gly Gly  Gly Cys Cys Ala Gly  Ala Cys Cys 
    2990                 2995                 3000             


Ala Thr  Thr Cys Cys Thr Gly  Thr Cys Thr Thr Thr  Gly Cys Cys 
    3005                 3010                 3015             


Thr Thr  Cys Cys Thr Gly Gly  Gly Ala Gly Cys Cys  Ala Thr Gly 
    3020                 3025                 3030             


Gly Thr  Gly Gly Thr Cys Cys  Thr Gly Gly Cys Cys  Thr Thr Cys 
    3035                 3040                 3045             


Thr Thr  Thr Gly Thr Gly Gly  Thr Ala Cys Ala Ala  Ala Thr Cys 
    3050                 3055                 3060             


Ala Ala  Cys Ala Ala Gly Gly  Cys Cys Ala Ala Gly  Ala Gly Cys 
    3065                 3070                 3075             


Ala Gly  Gly Cys Cys Gly Ala  Ala Gly Cys Gly Gly  Ala Gly Gly 
    3080                 3085                 3090             


Ala Ala  Gly Cys Cys Cys Ala  Gly Gly Gly Thr Gly  Ala Ala Gly 
    3095                 3100                 3105             


Cys Gly  Cys Cys Cys Gly Cys  Ala Gly Cys Thr Cys  Ala Thr Gly 
    3110                 3115                 3120             


Cys Ala  Gly Cys Ala Gly Gly  Thr Thr Cys Ala Cys  Cys Cys Gly 
    3125                 3130                 3135             


Cys Cys  Ala Ala Ala Gly Ala  Cys Cys Cys Cys Thr  Thr Cys Gly 
    3140                 3145                 3150             


Gly Thr  Gly Thr Gly Ala 
    3155                 


<210>  25
<211>  2079
<212>  DNA
<213>  Homo sapiens

<400>  25
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaggacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgtg     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctccagtga                            2079


<210>  26
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  27
<211>  1665
<212>  DNA
<213>  Homo sapiens

<400>  27
tatggtctag acgtaaacga tatatattca tgctcatggg gtcccgctga tgacggaaga       60

catttacaag gccctagtga cctggtgaaa aaggctttag taaaaggtgt tactgaggga      120

agagattcca aaggagcgat ttacgttttt gccagtggaa atggtggaac tcgtggtgat      180

aattgcaatt acgacggcta tactaattcc atatattcta ttactattgg ggctattgat      240

cacaaagatc tacatcctcc ttattccgaa ggttgttccg ccgtcatggc agtcacgtat      300

tcttcaggtt caggcgaata tattcattcg agtgatatca acggcagatg cagtaatagc      360

cacggtggaa cgtctgcggc tgctccatta gctgccggtg tttacacttt gttactagaa      420

gccaacccaa acctaacttg gagagacgta cagtatttat caatcttgtc tgcggtaggg      480

ttagaaaaga acgctgacgg agattggaga gatagcgcca tggggaagaa atactctcat      540

cgctatggct ttggtaaaat cgatgcccat aagttaattg aaatgtccaa gacctgggag      600

aatgttaacg cacaaacctg gttttacctg ccaacattgt atgtttccca gtccacaaac      660

tccacggaag agacattaga atccgtcata accatatcag aaaaaagtct tcaagatgct      720

aacttcaaga gaattgagca cgtcacggta actgtagata ttgatacaga aattagggga      780

actacgactg tcgatttaat atcaccagcg gggataattt caaaccttgg cgttgtaaga      840

ccaagagatg tttcatcaga gggattcaaa gactggacat tcatgtctgt agcacattgg      900

ggtgagaacg gcgtaggtga ttggaaaatc aaggttaaga caacagaaaa tggacacagg      960

attgacttcc acagttggag gctgaagctc tttggggaat ccattgattc atctaaaaca     1020

gaaactttcg tctttggaaa cgataaagag gaggttgaac cagctgctac agaaagtacc     1080

gtatcacaat attctgccag ttcaacttct atttccatca gcgctacttc tacatcttct     1140

atctcaattg gtgtggaaac gtcggccatt ccccaaacga ctactgcgag taccgatcct     1200

gattctgatc caaacactcc taaaaaactt tcctctccta ggcaagccat gcattatttt     1260

ttaacaatat ttttgattgg cgccacattt ttggtgttat acttcatgtt ttttatgaaa     1320

tcaaggagaa ggatcagaag gtcaagagcg gaaacgtatg aattcgatat cattgataca     1380

gactctgagt acgattctac tttggacaat ggaacttccg gaattactga gcccgaagag     1440

gttgaggact tcgattttga tttgtccgat gaagaccatc ttgcaagttt gtcttcatca     1500

gaaaacggtg atgctgaaca tacaattgat agtgtactaa caaacgaaaa tccatttagt     1560

gaccctataa agcaaaagtt cccaaatgac gccaacgcag aatctgcttc caataaatta     1620

caagaattac agcctgatgt tcctccatct tccggacgat cgtga                     1665


<210>  28
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys Val Arg Lys Tyr Ile Thr Leu Cys Phe Trp Trp Ala Phe Ser 
1               5                   10                  15      


Thr Ser Ala Leu Val Ser Ser Gln Gln Ile Pro Leu Lys Asp His Thr 
            20                  25                  30          


Ser Arg Gln Tyr Phe Ala Val Glu Ser Asn Glu Thr Leu Ser Arg Leu 
        35                  40                  45              


Glu Glu Met His Pro Asn Trp Lys Tyr Glu His Asp Val Arg Gly Leu 
    50                  55                  60                  


Pro Asn His Tyr Val Phe Ser Lys Glu Leu Leu Lys Leu Gly Lys Arg 
65                  70                  75                  80  


Ser Ser Leu Glu Glu Leu Gln Gly Asp Asn Asn Asp His Ile Leu Ser 
                85                  90                  95      


Val His Asp Leu Phe Pro Arg Asn Asp Leu Phe Lys Arg Leu Pro Val 
            100                 105                 110         


Pro Ala Pro Pro Met Asp Ser Ser Leu Leu Pro Val Lys Glu Ala Glu 
        115                 120                 125             


Asp Lys Leu Ser Ile Asn Asp Pro Leu Phe Glu Arg Gln Trp His Leu 
    130                 135                 140                 


Val Asn Pro Ser Phe Pro Gly Ser Asp Ile Asn Val Leu Asp Leu Trp 
145                 150                 155                 160 


Tyr Asn Asn Ile Thr Gly Ala Gly Val Val Ala Ala Ile Val Asp Asp 
                165                 170                 175     


Gly Leu Asp Tyr Glu Asn Glu Asp Leu Lys Asp Asn Phe Cys Ala Glu 
            180                 185                 190         


Gly Ser Trp Asp Phe Asn Asp Asn Thr Asn Leu Pro Lys Pro Arg Leu 
        195                 200                 205             


Ser Asp Asp Tyr His Gly Thr Arg Cys Ala Gly Glu Ile Ala Ala Lys 
    210                 215                 220                 


Lys Gly Asn Asn Phe Cys Gly Val Gly Val Gly Tyr Asn Ala Lys Ile 
225                 230                 235                 240 


Ser Gly Ile Arg Ile Leu Ser Gly Asp Ile Thr Thr Glu Asp Glu Ala 
                245                 250                 255     


Ala Ser Leu Ile Tyr Gly Leu Asp Val Asn Asp Ile Tyr Ser Cys Ser 
            260                 265                 270         


Trp Gly Pro Ala Asp Asp Gly Arg His Leu Gln Gly Pro Ser Asp Leu 
        275                 280                 285             


Val Lys Lys Ala Leu Val Lys Gly Val Thr Glu Gly Arg Asp Ser Lys 
    290                 295                 300                 


Gly Ala Ile Tyr Val Phe Ala Ser Gly Asn Gly Gly Thr Arg Gly Asp 
305                 310                 315                 320 


Asn Cys Asn Tyr Asp Gly Tyr Thr Asn Ser Ile Tyr Ser Ile Thr Ile 
                325                 330                 335     


Gly Ala Ile Asp His Lys Asp Leu His Pro Pro Tyr Ser Glu Gly Cys 
            340                 345                 350         


Ser Ala Val Met Ala Val Thr Tyr Ser Ser Gly Ser Gly Glu Tyr Ile 
        355                 360                 365             


His Ser Ser Asp Ile Asn Gly Arg Cys Ser Asn Ser His Gly Gly Thr 
    370                 375                 380                 


Ser Ala Ala Ala Pro Leu Ala Ala Gly Val Tyr Thr Leu Leu Leu Glu 
385                 390                 395                 400 


Ala Asn Pro Asn Leu Thr Trp Arg Asp Val Gln Tyr Leu Ser Ile Leu 
                405                 410                 415     


Ser Ala Val Gly Leu Glu Lys Asn Ala Asp Gly Asp Trp Arg Asp Ser 
            420                 425                 430         


Ala Met Gly Lys Lys Tyr Ser His Arg Tyr Gly Phe Gly Lys Ile Asp 
        435                 440                 445             


Ala His Lys Leu Ile Glu Met Ser Lys Thr Trp Glu Asn Val Asn Ala 
    450                 455                 460                 


Gln Thr Trp Phe Tyr Leu Pro Thr Leu Tyr Val Ser Gln Ser Thr Asn 
465                 470                 475                 480 


Ser Thr Glu Glu Thr Leu Glu Ser Val Ile Thr Ile Ser Glu Lys Ser 
                485                 490                 495     


Leu Gln Asp Ala Asn Phe Lys Arg Ile Glu His Val Thr Val Thr Val 
            500                 505                 510         


Asp Ile Asp Thr Glu Ile Arg Gly Thr Thr Thr Val Asp Leu Ile Ser 
        515                 520                 525             


Pro Ala Gly Ile Ile Ser Asn Leu Gly Val Val Arg Pro Arg Asp Val 
    530                 535                 540                 


Ser Ser Glu Gly Phe Lys Asp Trp Thr Phe Met Ser Val Ala His Trp 
545                 550                 555                 560 


Gly Glu Asn Gly Val Gly Asp Trp Lys Ile Lys Val Lys Thr Thr Glu 
                565                 570                 575     


Asn Gly His Arg Ile Asp Phe His Ser Trp Arg Leu Lys Leu Phe Gly 
            580                 585                 590         


Glu Ser Ile Asp Ser Ser Lys Thr Glu Thr Phe Val Phe Gly Asn Asp 
        595                 600                 605             


Lys Glu Glu Val Glu Pro Ala Ala Thr Glu Ser Thr Val Ser Gln Tyr 
    610                 615                 620                 


Ser Ala Ser Ser Thr Ser Ile Ser Ile Ser Ala Thr Ser Thr Ser Ser 
625                 630                 635                 640 


Ile Ser Ile Gly Val Glu Thr Ser Ala Ile Pro Gln Thr Thr Thr Ala 
                645                 650                 655     


Ser Thr Asp Pro Asp Ser Asp Pro Asn Thr Pro Lys Lys Leu Ser Ser 
            660                 665                 670         


Pro Arg Gln Ala Met His Tyr Phe Leu Thr Ile Phe Leu Ile Gly Ala 
        675                 680                 685             


Thr Phe Leu Val Leu Tyr Phe Met Phe Phe Met Lys Ser Arg Arg Arg 
    690                 695                 700                 


Ile Arg Arg Ser Arg Ala Glu Thr Tyr Glu Phe Asp Ile Ile Asp Thr 
705                 710                 715                 720 


Asp Ser Glu Tyr Asp Ser Thr Leu Asp Asn Gly Thr Ser Gly Ile Thr 
                725                 730                 735     


Glu Pro Glu Glu Val Glu Asp Phe Asp Phe Asp Leu Ser Asp Glu Asp 
            740                 745                 750         


His Leu Ala Ser Leu Ser Ser Ser Glu Asn Gly Asp Ala Glu His Thr 
        755                 760                 765             


Ile Asp Ser Val Leu Thr Asn Glu Asn Pro Phe Ser Asp Pro Ile Lys 
    770                 775                 780                 


Gln Lys Phe Pro Asn Asp Ala Asn Ala Glu Ser Ala Ser Asn Lys Leu 
785                 790                 795                 800 


Gln Glu Leu Gln Pro Asp Val Pro Pro Ser Ser Gly Arg Ser 
                805                 810                 


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
atctacacca tctccatcag cagc                                              24


<210>  30
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
aaggcggccg ctcagccttg aaatgtacat gttttgc                                37


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
agcgagggag cagcgagg                                                     18


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
ggtagttgac atggcggttg g                                                 21


<210>  33
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
cagcgactta agccaccatg ggctggggga gccg                                   34


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
gtaggttgtg gccagcgtgg                                                   20


<210>  35
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  p55N-PC5-005

<400>  35
atgggctggg ggagccgctg ctgctgcccg ggacgtttgg acctgctgtg cgtgctggcg       60

ctgctcgggg gctgcctgct ccccgtgtgt cggacgcgcg tctacaccaa ccactgggca      120

gtcaaaatcg ccgggggctt cccggaggcc aaccgtatcg ccagcaagta cggattcatc      180

aacataggac agataggggc cctgaaggac tactaccact tctaccatag caggacgatt      240

aaaaggtcag ttatctcgag cagagggacc cacagtttca tttcaatgga accaaaggtg      300

gaatggatcc aacagcaagt ggtaaaaaag cggacaaaga gggattatga cttcagtcgt      360

gcccagtcta cctatttcaa tgatcccaag tggcccagta tgtggtatat gcactgcagt      420

gacaatacac atccctgcca gtctgacatg aatatcgaag gagcctggaa gagaggctac      480

acgggaaaga acattgtggt cactatcctg gatgacggaa ttgagagaac ccatccagat      540

ctgatgcaaa actacgatgc tctggcaagt tgcgacgtga atgggaatga cttggaccca      600

atgcctcgtt atgatgcaag caacgagaac aagcatggga ctcgctgtgc tggagaagtg      660

gcagccgctg caaacaattc gcactgcaca gtcggaattg ctttcaacgc caagatcgga      720

ggagtgcgaa tgctggacgg agatgtcacg gacatggttg aagcaaaatc agttagcttc      780

aacccccagc acgtgcacat ttacagcgcc agctggggcc cggatgatga tggcaagact      840

gtggacggac cagcccccct cacccggcaa gcctttgaaa acggcgttag aatggggcgg      900

agaggcctcg gctctgtgtt tgtttgggca tctggaaatg gtggaaggag caaagaccac      960

tgctcctgtg atggctacac caacagcatc tacaccatct ccatcagcag cactgcagaa     1020

agcggaaaga aaccttggta cctggaagag tgttcatcca cgctggccac aacctacagc     1080

agcggggagt cctacgataa gaaaatcatc actacagatc tgaggcagcg ttgcacggac     1140

aaccacactg ggacgtcagc ctcagccccc atggctgcag gcatcattgc gctggccctg     1200

gaagccaatc cgtttctgac ctggagagac gtacagcatg ttattgtcag gacttcccgt     1260

gcgggacatt tgaacgctaa tgactggaaa accaatgctg ctggttttaa ggtgagccat     1320

ctttatggat ttggactgat ggacgcagaa gccatggtga tggaggcaga gaagtggacc     1380

accgttcccc ggcagcacgt gtgtgtggag agcacagacc gacaaatcaa gacaatccgc     1440

cctaacagtg cagtgcgctc catctacaaa gcctcaggct gctcagataa ccccaaccgc     1500

catgtcaact acctggagca cgtcgttgtg cgcatcacca tcacccaccc caggagagga     1560

gacctggcca tctacctgac ctcgccctct ggaactaggt ctcagctttt ggccaacagg     1620

ctatttgatc actccatgga aggattcaaa aactgggagt tcatgaccat tcattgctgg     1680

ggagaaagag ctgctggtga ctgggtcctt gaagtttatg atactccctc tcagctaagg     1740

aactttaaga ctccaggtaa attgaaagaa tggtctttgg tcctctacgg cacctccgtg     1800

cagccatatt caccaaccaa tgaatttccg aaagtggaac ggttccgcta tagccgagtt     1860

gaagacccca cagacgacta tggcacagag gattatgcag gtccctgcga ccctgagtgc     1920

agtgaggttg gctgtgacgg gccaggacca gaccactgca atgactgttt gcactactac     1980

tacaagctga aaaacaatac caggatctgt gtctccagct gcccccctgg ccactaccac     2040

gccgacaaga agcgctgcag gaagtgtgcc cccaactgtg agtcctgctt tgggagccat     2100

ggtgaccaat gcatgtcctg caaatatgga tactttctga atgaagaaac caacagctgt     2160

gttactcact gccctgatgg gtcatatcag gataccaaga aaaatctttg ccggaaatgc     2220

agtgaaaact gcaagacatg tactgaattc cataactgta cagaatgtag ggatgggtta     2280

agcctgcagg gatcccggtg ctctgtctcc tgtgaagatg gacggtattt caacggccag     2340

gactgccagc cctgccaccg cttctgcgcc acttgtgctg gggcaggagc tgatgggtgc     2400

attaactgca cagagggcta cttcatggag gatgggagat gcgtgcagag ctgtagtatc     2460

agctattact ttgaccactc ttcagagaat ggatacaaat cctgcaaaaa atgtgatatc     2520

agttgtttga cgtgcaatgg cccaggattc aagaactgta caagctgccc tagtgggtat     2580

ctcttagact taggaatgtg tcaaatggga gccatttgca aggatgcaac ggaagagtcc     2640

tgggcggaag gaggcttctg tatgcttgtg aaaaagaaca atctgtgcca acggaaggtt     2700

cttcaacaac tttgctgcaa aacatgtaca tttcaaggc                            2739


<210>  36
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
ggtaagcttg ccatggagct gaggccctgg ttgc                                   34


<210>  37
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
gttttcaatc tctaggaccc actcgcc                                           27


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  38
gccaggccac atgactactc cgc                                               23


<210>  39
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  39
ggtgaattct cactcaggca ggtgtgaggg cagc                                   34


<210>  40
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  40
gcgctagccg tacggccgcc accatgaaag tgaggaaata tattacttta tgc              53


<210>  41
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
gctattgatc acaaagatct acatcctcc                                         29


<210>  42
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  42
ggaggatgta gatctttgtg atcaatagc                                         29


<210>  43
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  43
gcgaattccg gtccgtcatt gcctagggct cgagagtttt ttaggagtgt ttggatcag        59


<210>  44
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  44
gcatggactc cgatcccaac g                                                 21


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  45
cgttgggatc ggagtccatg c                                                 21


<210>  46
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  46
ggtaagcttg ccgccaccat gccgaagggg aggcagaaag                             40


<210>  47
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  47
tttgaattct cagttggggg tgatggtgta acc                                    33


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  48
ggcacctgaa taaccgacgg                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  49
cgtcacgttg atgtccctgc                                                   20


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  50

Glu Phe Ala Gly Ala Ala Ala Val 
1               5               


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  51

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  52

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  53

Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  54

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  55

Gly Gly Gly Gly Ser 
1               5   


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  56

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  57
<211>  1860
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly Trp Gly Ser Arg Cys Cys Cys Pro Gly Arg Leu Asp Leu Leu 
1               5                   10                  15      


Cys Val Leu Ala Leu Leu Gly Gly Cys Leu Leu Pro Val Cys Arg Thr 
            20                  25                  30          


Arg Val Tyr Thr Asn His Trp Ala Val Lys Ile Ala Gly Gly Phe Pro 
        35                  40                  45              


Glu Ala Asn Arg Ile Ala Ser Lys Tyr Gly Phe Ile Asn Ile Gly Gln 
    50                  55                  60                  


Ile Gly Ala Leu Lys Asp Tyr Tyr His Phe Tyr His Ser Arg Thr Ile 
65                  70                  75                  80  


Lys Arg Ser Val Ile Ser Ser Arg Gly Thr His Ser Phe Ile Ser Met 
                85                  90                  95      


Glu Pro Lys Val Glu Trp Ile Gln Gln Gln Val Val Lys Lys Arg Thr 
            100                 105                 110         


Lys Arg Asp Tyr Asp Phe Ser Arg Ala Gln Ser Thr Tyr Phe Asn Asp 
        115                 120                 125             


Pro Lys Trp Pro Ser Met Trp Tyr Met His Cys Ser Asp Asn Thr His 
    130                 135                 140                 


Pro Cys Gln Ser Asp Met Asn Ile Glu Gly Ala Trp Lys Arg Gly Tyr 
145                 150                 155                 160 


Thr Gly Lys Asn Ile Val Val Thr Ile Leu Asp Asp Gly Ile Glu Arg 
                165                 170                 175     


Thr His Pro Asp Leu Met Gln Asn Tyr Asp Ala Leu Ala Ser Cys Asp 
            180                 185                 190         


Val Asn Gly Asn Asp Leu Asp Pro Met Pro Arg Tyr Asp Ala Ser Asn 
        195                 200                 205             


Glu Asn Lys His Gly Thr Arg Cys Ala Gly Glu Val Ala Ala Ala Ala 
    210                 215                 220                 


Asn Asn Ser His Cys Thr Val Gly Ile Ala Phe Asn Ala Lys Ile Gly 
225                 230                 235                 240 


Gly Val Arg Met Leu Asp Gly Asp Val Thr Asp Met Val Glu Ala Lys 
                245                 250                 255     


Ser Val Ser Phe Asn Pro Gln His Val His Ile Tyr Ser Ala Ser Trp 
            260                 265                 270         


Gly Pro Asp Asp Asp Gly Lys Thr Val Asp Gly Pro Ala Pro Leu Thr 
        275                 280                 285             


Arg Gln Ala Phe Glu Asn Gly Val Arg Met Gly Arg Arg Gly Leu Gly 
    290                 295                 300                 


Ser Val Phe Val Trp Ala Ser Gly Asn Gly Gly Arg Ser Lys Asp His 
305                 310                 315                 320 


Cys Ser Cys Asp Gly Tyr Thr Asn Ser Ile Tyr Thr Ile Ser Ile Ser 
                325                 330                 335     


Ser Thr Ala Glu Ser Gly Lys Lys Pro Trp Tyr Leu Glu Glu Cys Ser 
            340                 345                 350         


Ser Thr Leu Ala Thr Thr Tyr Ser Ser Gly Glu Ser Tyr Asp Lys Lys 
        355                 360                 365             


Ile Ile Thr Thr Asp Leu Arg Gln Arg Cys Thr Asp Asn His Thr Gly 
    370                 375                 380                 


Thr Ser Ala Ser Ala Pro Met Ala Ala Gly Ile Ile Ala Leu Ala Leu 
385                 390                 395                 400 


Glu Ala Asn Pro Phe Leu Thr Trp Arg Asp Val Gln His Val Ile Val 
                405                 410                 415     


Arg Thr Ser Arg Ala Gly His Leu Asn Ala Asn Asp Trp Lys Thr Asn 
            420                 425                 430         


Ala Ala Gly Phe Lys Val Ser His Leu Tyr Gly Phe Gly Leu Met Asp 
        435                 440                 445             


Ala Glu Ala Met Val Met Glu Ala Glu Lys Trp Thr Thr Val Pro Arg 
    450                 455                 460                 


Gln His Val Cys Val Glu Ser Thr Asp Arg Gln Ile Lys Thr Ile Arg 
465                 470                 475                 480 


Pro Asn Ser Ala Val Arg Ser Ile Tyr Lys Ala Ser Gly Cys Ser Asp 
                485                 490                 495     


Asn Pro Asn Arg His Val Asn Tyr Leu Glu His Val Val Val Arg Ile 
            500                 505                 510         


Thr Ile Thr His Pro Arg Arg Gly Asp Leu Ala Ile Tyr Leu Thr Ser 
        515                 520                 525             


Pro Ser Gly Thr Arg Ser Gln Leu Leu Ala Asn Arg Leu Phe Asp His 
    530                 535                 540                 


Ser Met Glu Gly Phe Lys Asn Trp Glu Phe Met Thr Ile His Cys Trp 
545                 550                 555                 560 


Gly Glu Arg Ala Ala Gly Asp Trp Val Leu Glu Val Tyr Asp Thr Pro 
                565                 570                 575     


Ser Gln Leu Arg Asn Phe Lys Thr Pro Gly Lys Leu Lys Glu Trp Ser 
            580                 585                 590         


Leu Val Leu Tyr Gly Thr Ser Val Gln Pro Tyr Ser Pro Thr Asn Glu 
        595                 600                 605             


Phe Pro Lys Val Glu Arg Phe Arg Tyr Ser Arg Val Glu Asp Pro Thr 
    610                 615                 620                 


Asp Asp Tyr Gly Thr Glu Asp Tyr Ala Gly Pro Cys Asp Pro Glu Cys 
625                 630                 635                 640 


Ser Glu Val Gly Cys Asp Gly Pro Gly Pro Asp His Cys Asn Asp Cys 
                645                 650                 655     


Leu His Tyr Tyr Tyr Lys Leu Lys Asn Asn Thr Arg Ile Cys Val Ser 
            660                 665                 670         


Ser Cys Pro Pro Gly His Tyr His Ala Asp Lys Lys Arg Cys Arg Lys 
        675                 680                 685             


Cys Ala Pro Asn Cys Glu Ser Cys Phe Gly Ser His Gly Asp Gln Cys 
    690                 695                 700                 


Met Ser Cys Lys Tyr Gly Tyr Phe Leu Asn Glu Glu Thr Asn Ser Cys 
705                 710                 715                 720 


Val Thr His Cys Pro Asp Gly Ser Tyr Gln Asp Thr Lys Lys Asn Leu 
                725                 730                 735     


Cys Arg Lys Cys Ser Glu Asn Cys Lys Thr Cys Thr Glu Phe His Asn 
            740                 745                 750         


Cys Thr Glu Cys Arg Asp Gly Leu Ser Leu Gln Gly Ser Arg Cys Ser 
        755                 760                 765             


Val Ser Cys Glu Asp Gly Arg Tyr Phe Asn Gly Gln Asp Cys Gln Pro 
    770                 775                 780                 


Cys His Arg Phe Cys Ala Thr Cys Ala Gly Ala Gly Ala Asp Gly Cys 
785                 790                 795                 800 


Ile Asn Cys Thr Glu Gly Tyr Phe Met Glu Asp Gly Arg Cys Val Gln 
                805                 810                 815     


Ser Cys Ser Ile Ser Tyr Tyr Phe Asp His Ser Ser Glu Asn Gly Tyr 
            820                 825                 830         


Lys Ser Cys Lys Lys Cys Asp Ile Ser Cys Leu Thr Cys Asn Gly Pro 
        835                 840                 845             


Gly Phe Lys Asn Cys Thr Ser Cys Pro Ser Gly Tyr Leu Leu Asp Leu 
    850                 855                 860                 


Gly Met Cys Gln Met Gly Ala Ile Cys Lys Asp Gly Glu Tyr Val Asp 
865                 870                 875                 880 


Glu His Gly His Cys Gln Thr Cys Glu Ala Ser Cys Ala Lys Cys Gln 
                885                 890                 895     


Gly Pro Thr Gln Glu Asp Cys Thr Thr Cys Pro Met Thr Arg Ile Phe 
            900                 905                 910         


Asp Asp Gly Arg Cys Val Ser Asn Cys Pro Ser Trp Lys Phe Glu Phe 
        915                 920                 925             


Glu Asn Gln Cys His Pro Cys His His Thr Cys Gln Arg Cys Gln Gly 
    930                 935                 940                 


Ser Gly Pro Thr His Cys Thr Ser Cys Gly Ala Asp Asn Tyr Gly Arg 
945                 950                 955                 960 


Glu His Phe Leu Tyr Gln Gly Glu Cys Gly Asp Ser Cys Pro Glu Gly 
                965                 970                 975     


His Tyr Ala Thr Glu Gly Asn Thr Cys Leu Pro Cys Pro Asp Asn Cys 
            980                 985                 990         


Glu Leu Cys His Ser Val His Val  Cys Thr Arg Cys Met  Lys Gly Tyr 
        995                 1000                 1005             


Phe Ile  Ala Pro Thr Asn His  Thr Cys Gln Lys Leu  Glu Cys Gly 
    1010                 1015                 1020             


Gln Gly  Glu Val Gln Asp Pro  Asp Tyr Glu Glu Cys  Val Pro Cys 
    1025                 1030                 1035             


Glu Glu  Gly Cys Leu Gly Cys  Ser Leu Asp Asp Pro  Gly Thr Cys 
    1040                 1045                 1050             


Thr Ser  Cys Ala Met Gly Tyr  Tyr Arg Phe Asp His  His Cys Tyr 
    1055                 1060                 1065             


Lys Thr  Cys Pro Glu Lys Thr  Tyr Ser Glu Glu Val  Glu Cys Lys 
    1070                 1075                 1080             


Ala Cys  Asp Ser Asn Cys Gly  Ser Cys Asp Gln Asn  Gly Cys Tyr 
    1085                 1090                 1095             


Trp Cys  Glu Glu Gly Phe Phe  Leu Leu Gly Gly Ser  Cys Val Arg 
    1100                 1105                 1110             


Lys Cys  Gly Pro Gly Phe Tyr  Gly Asp Gln Glu Met  Gly Glu Cys 
    1115                 1120                 1125             


Glu Ser  Cys His Arg Ala Cys  Glu Thr Cys Thr Gly  Pro Gly His 
    1130                 1135                 1140             


Asp Glu  Cys Ser Ser Cys Gln  Glu Gly Leu Gln Leu  Leu Arg Gly 
    1145                 1150                 1155             


Met Cys  Val His Ala Thr Lys  Thr Gln Glu Glu Gly  Lys Phe Trp 
    1160                 1165                 1170             


Asn Asp  Ile Leu Arg Lys Leu  Gln Pro Cys His Ser  Ser Cys Lys 
    1175                 1180                 1185             


Thr Cys  Asn Gly Ser Ala Thr  Leu Cys Thr Ser Cys  Pro Lys Gly 
    1190                 1195                 1200             


Ala Tyr  Leu Leu Ala Gln Ala  Cys Val Ser Ser Cys  Pro Gln Gly 
    1205                 1210                 1215             


Thr Trp  Pro Ser Val Arg Ser  Gly Ser Cys Glu Asn  Cys Thr Glu 
    1220                 1225                 1230             


Ala Cys  Ala Ile Cys Ser Gly  Ala Asp Leu Cys Lys  Lys Cys Gln 
    1235                 1240                 1245             


Met Gln  Pro Gly His Pro Leu  Phe Leu His Glu Gly  Arg Cys Tyr 
    1250                 1255                 1260             


Ser Lys  Cys Pro Glu Gly Ser  Tyr Ala Glu Asp Gly  Ile Cys Glu 
    1265                 1270                 1275             


Arg Cys  Ser Ser Pro Cys Arg  Thr Cys Glu Gly Asn  Ala Thr Asn 
    1280                 1285                 1290             


Cys His  Ser Cys Glu Gly Gly  His Val Leu His His  Gly Val Cys 
    1295                 1300                 1305             


Gln Glu  Asn Cys Pro Glu Arg  His Val Ala Val Lys  Gly Val Cys 
    1310                 1315                 1320             


Lys His  Cys Pro Glu Met Cys  Gln Asp Cys Ile His  Glu Lys Thr 
    1325                 1330                 1335             


Cys Lys  Glu Cys Thr Pro Glu  Phe Phe Leu His Asp  Asp Met Cys 
    1340                 1345                 1350             


His Gln  Ser Cys Pro Arg Gly  Phe Tyr Ala Asp Ser  Arg His Cys 
    1355                 1360                 1365             


Val Pro  Cys His Lys Asp Cys  Leu Glu Cys Ser Gly  Pro Lys Ala 
    1370                 1375                 1380             


Asp Asp  Cys Glu Leu Cys Leu  Glu Ser Ser Trp Val  Leu Tyr Asp 
    1385                 1390                 1395             


Gly Leu  Cys Leu Glu Glu Cys  Pro Ala Gly Thr Tyr  Tyr Glu Lys 
    1400                 1405                 1410             


Glu Thr  Lys Glu Cys Arg Asp  Cys His Lys Ser Cys  Leu Thr Cys 
    1415                 1420                 1425             


Ser Ser  Ser Gly Thr Cys Thr  Thr Cys Gln Lys Gly  Leu Ile Met 
    1430                 1435                 1440             


Asn Pro  Arg Gly Ser Cys Met  Ala Asn Glu Lys Cys  Ser Pro Ser 
    1445                 1450                 1455             


Glu Tyr  Trp Asp Glu Asp Ala  Pro Gly Cys Lys Pro  Cys His Val 
    1460                 1465                 1470             


Lys Cys  Phe His Cys Met Gly  Pro Ala Glu Asp Gln  Cys Gln Thr 
    1475                 1480                 1485             


Cys Pro  Met Asn Ser Leu Leu  Leu Asn Thr Thr Cys  Val Lys Asp 
    1490                 1495                 1500             


Cys Pro  Glu Gly Tyr Tyr Ala  Asp Glu Asp Ser Asn  Arg Cys Ala 
    1505                 1510                 1515             


His Cys  His Ser Ser Cys Arg  Thr Cys Glu Gly Arg  His Ser Arg 
    1520                 1525                 1530             


Gln Cys  His Ser Cys Arg Pro  Gly Trp Phe Gln Leu  Gly Lys Glu 
    1535                 1540                 1545             


Cys Leu  Leu Gln Cys Arg Glu  Gly Tyr Tyr Ala Asp  Asn Ser Thr 
    1550                 1555                 1560             


Gly Arg  Cys Glu Arg Cys Asn  Arg Ser Cys Lys Gly  Cys Gln Gly 
    1565                 1570                 1575             


Pro Arg  Pro Thr Asp Cys Leu  Ser Cys Asp Arg Phe  Phe Phe Leu 
    1580                 1585                 1590             


Leu Arg  Ser Lys Gly Glu Cys  His Arg Ser Cys Pro  Asp His Tyr 
    1595                 1600                 1605             


Tyr Val  Glu Gln Ser Thr Gln  Thr Cys Glu Arg Cys  His Pro Thr 
    1610                 1615                 1620             


Cys Asp  Gln Cys Lys Gly Lys  Gly Ala Leu Asn Cys  Leu Ser Cys 
    1625                 1630                 1635             


Val Trp  Ser Tyr His Leu Met  Gly Gly Ile Cys Thr  Ser Asp Cys 
    1640                 1645                 1650             


Leu Val  Gly Glu Tyr Arg Val  Gly Glu Gly Glu Lys  Phe Asn Cys 
    1655                 1660                 1665             


Glu Lys  Cys His Glu Ser Cys  Met Glu Cys Lys Gly  Pro Gly Ala 
    1670                 1675                 1680             


Lys Asn  Cys Thr Leu Cys Pro  Ala Asn Leu Val Leu  His Met Asp 
    1685                 1690                 1695             


Asp Ser  His Cys Leu His Cys  Cys Asn Thr Ser Asp  Pro Pro Ser 
    1700                 1705                 1710             


Ala Gln  Glu Cys Cys Asp Cys  Gln Asp Thr Thr Asp  Glu Cys Ile 
    1715                 1720                 1725             


Leu Arg  Thr Ser Lys Val Arg  Pro Ala Thr Glu His  Phe Lys Thr 
    1730                 1735                 1740             


Ala Leu  Phe Ile Thr Ser Ser  Met Met Leu Val Leu  Leu Leu Gly 
    1745                 1750                 1755             


Ala Ala  Val Val Val Trp Lys  Lys Ser Arg Gly Arg  Val Gln Pro 
    1760                 1765                 1770             


Ala Ala  Lys Ala Gly Tyr Glu  Lys Leu Ala Asp Pro  Asn Lys Ser 
    1775                 1780                 1785             


Tyr Ser  Ser Tyr Lys Ser Ser  Tyr Arg Glu Ser Thr  Ser Phe Glu 
    1790                 1795                 1800             


Glu Asp  Gln Val Ile Glu Tyr  Arg Asp Arg Asp Tyr  Asp Glu Asp 
    1805                 1810                 1815             


Asp Asp  Asp Asp Ile Val Tyr  Met Gly Gln Asp Gly  Thr Val Tyr 
    1820                 1825                 1830             


Arg Lys  Phe Lys Tyr Gly Leu  Leu Asp Asp Asp Asp  Ile Asp Glu 
    1835                 1840                 1845             


Leu Glu  Tyr Asp Asp Glu Ser  Tyr Ser Tyr Tyr Gln  
    1850                 1855                 1860 


<210>  58
<211>  9538
<212>  DNA
<213>  Homo sapiens

<400>  58
atttatgcag agcaggagct gctgccattg ccactcagaa tcctcgcgcg ctgctcggag       60

ccggagggag cgctgggagc gagcaagcga gcgtttggag cccgggccag cagagggggc      120

gcccggtcgc tgcctgtacc gctcccgctg gtcatctccg ccgcgctcgg gggccccggg      180

aggagcgaga ccgagtcgga gagtccggga gccaagccgg gcgaaaccca actgcggagg      240

acgcccgccc cactcagcct cctcctgcgt ccgagccggg gagcatcgcc gagcgcccca      300

cgggccggag agctgggagc acaggtcccg gcagccccag ggatggtcta ggagccggcg      360

taaggctcgc tgctctgctc cctgccgggg ctagccgcct cctgccgatc gcccggggct      420

gcgagctgcg gcggcccggg gctgctcgcc gggcggcgca ggccggagaa gttagttgtg      480

cgcgccctta gtgcgcggaa ccagccagcg agcgagggag cagcgaggcg ccgggaccat      540

gggctggggg agccgctgct gctgcccggg acgtttggac ctgctgtgcg tgctggcgct      600

gctcgggggc tgcctgctcc ccgtgtgtcg gacgcgcgtc tacaccaacc actgggcagt      660

caaaatcgcc gggggcttcc cggaggccaa ccgtatcgcc agcaagtacg gattcatcaa      720

cataggacag ataggggccc tgaaggacta ctaccacttc taccatagca ggacgattaa      780

aaggtcagtt atctcgagca gagggaccca cagtttcatt tcaatggaac caaaggtgga      840

atggatccaa cagcaagtgg taaaaaagcg gacaaagagg gattatgact tcagtcgtgc      900

ccagtctacc tatttcaatg atcccaagtg gcccagcatg tggtatatgc actgcagtga      960

caatacacat ccctgccagt ctgacatgaa tatcgaagga gcctggaaga gaggctacac     1020

gggaaagaac attgtggtca ctatcctgga tgacggaatt gagagaaccc atccagatct     1080

gatgcaaaac tacgatgctc tggcaagttg cgacgtgaat gggaatgact tggacccaat     1140

gcctcgttat gatgcaagca acgagaacaa gcatgggact cgctgtgctg gagaagtggc     1200

agccgctgca aacaattcgc actgcacagt cggaattgct ttcaacgcca agatcggagg     1260

agtgcgaatg ctggacggag atgtcacgga catggttgaa gcaaaatcag ttagcttcaa     1320

cccccagcac gtgcacattt acagcgccag ctggggcccg gatgatgatg gcaagactgt     1380

ggacggacca gcccccctca cccggcaagc ctttgaaaac ggcgttagaa tggggcggag     1440

aggcctcggc tctgtgtttg tttgggcatc tggaaatggt ggaaggagca aagaccactg     1500

ctcctgtgat ggctacacca acagcatcta caccatctcc atcagcagca ctgcagaaag     1560

cggaaagaaa ccttggtacc tggaagagtg ttcatccacg ctggccacaa cctacagcag     1620

cggggagtcc tacgataaga aaatcatcac tacagatctg aggcagcgtt gcacggacaa     1680

ccacactggg acgtcagcct cagcccccat ggctgcaggc atcattgcgc tggccctgga     1740

agccaatccg tttctgacct ggagagacgt acagcatgtt attgtcagga cttcccgtgc     1800

gggacatttg aacgctaatg actggaaaac caatgctgct ggttttaagg tgagccatct     1860

ttatggattt ggactgatgg acgcagaagc catggtgatg gaggcagaga agtggaccac     1920

cgttccccgg cagcacgtgt gtgtggagag cacagaccga caaatcaaga caatccgccc     1980

taacagtgca gtgcgctcca tctacaaagc ttcaggctgc tcggataacc ccaaccgcca     2040

tgtcaactac ctggagcacg tcgttgtgcg catcaccatc acccacccca ggagaggaga     2100

cctggccatc tacctgacct cgccctctgg aactaggtct cagcttttgg ccaacaggct     2160

atttgatcac tccatggaag gattcaaaaa ctgggagttc atgaccattc attgctgggg     2220

agaaagagct gctggtgact gggtccttga agtttatgat actccctctc agctaaggaa     2280

ctttaagact ccaggtaaat tgaaagaatg gtctttggtc ctctacggca cctccgtgca     2340

gccatattca ccaaccaatg aatttccgaa agtggaacgg ttccgctata gccgagttga     2400

agaccccaca gacgactatg gcacagagga ttatgcaggt ccctgcgacc ctgagtgcag     2460

tgaggttggc tgtgacgggc caggaccaga ccactgcaat gactgtttgc actactacta     2520

caagctgaaa aacaatacca ggatctgtgt ctccagctgc ccccctggcc actaccacgc     2580

cgacaagaag cgctgcagga agtgtgcccc caactgtgag tcctgctttg ggagccatgg     2640

tgaccaatgc atgtcctgca aatatggata ctttctgaat gaagaaacca acagctgtgt     2700

tactcactgc cctgatgggt catatcagga taccaagaaa aatctttgcc ggaaatgcag     2760

tgaaaactgc aagacatgta ctgaattcca taactgtaca gaatgtaggg atgggttaag     2820

cctgcaggga tcccggtgct ctgtctcctg tgaagatgga cggtatttca acggccagga     2880

ctgccagccc tgccaccgct tctgcgccac ttgtgctggg gcaggagctg atgggtgcat     2940

taactgcaca gagggctact tcatggagga tgggagatgc gtgcagagct gtagtatcag     3000

ctattacttt gaccactctt cagagaatgg atacaaatcc tgcaaaaaat gtgatatcag     3060

ttgtttgacg tgcaatggcc caggattcaa gaactgtaca agctgcccta gtgggtatct     3120

cttagactta ggaatgtgtc aaatgggagc catttgcaag gatggagaat atgttgatga     3180

gcatggccac tgccagacct gtgaggcctc atgtgccaag tgccagggac caacccagga     3240

agactgcact acctgcccca tgacaaggat ttttgatgat ggccgctgtg tttcgaactg     3300

cccctcatgg aaatttgaat ttgagaacca atgccatcca tgccaccaca cctgccagag     3360

atgccaagga agtggcccta cccactgcac ctcctgtgga gcagacaact atggccgaga     3420

gcacttcctg taccagggag agtgtggaga tagctgccca gagggccact atgccactga     3480

ggggaacacc tgcctgccct gcccagacaa ctgtgagctt tgccacagcg tgcatgtctg     3540

cacaagatgc atgaagggct acttcatagc gcccaccaac cacacatgcc agaagttaga     3600

gtgtggacaa ggtgaagtcc aagacccaga ctatgaagaa tgtgtccctt gtgaagaagg     3660

atgtctggga tgcagcttgg atgatccagg aacatgtaca tcttgcgcta tggggtatta     3720

caggtttgat caccattgtt ataaaacctg tcctgagaag acctacagtg aggaagtgga     3780

atgcaaggcg tgtgatagta actgtggcag ctgtgaccag aatgggtgtt actggtgtga     3840

agagggcttc tttctcttag gtggcagttg tgtgaggaaa tgtggtcctg gattctatgg     3900

tgaccaagaa atgggagaat gtgagtcctg ccaccgagca tgcgaaacct gcacaggccc     3960

tggtcatgac gagtgcagca gctgccagga aggactgcag ctgctgcgtg ggatgtgcgt     4020

gcatgccacc aagacccagg aggagggcaa attctggaat gatattttga gaaaactcca     4080

gccttgtcat tcttcttgta aaacctgcaa tggatctgca actctgtgca cttcatgtcc     4140

caaaggtgca tatcttctgg ctcaggcctg tgtttcctcc tgtccccaag gcacatggcc     4200

ttccgtaagg agtgggagct gcgagaactg tacggaggcc tgtgccatct gctctggagc     4260

cgatctttgc aaaaaatgcc agatgcagcc gggccaccct ctcttcctcc atgaaggcag     4320

gtgctactcc aagtgcccgg agggctctta tgcagaagac ggcatatgtg aacgctgtag     4380

ctctccttgc agaacatgtg aaggaaacgc caccaactgc cattcttgtg aaggaggcca     4440

cgtcctgcac cacggagtgt gccaggaaaa ctgccccgag aggcacgtgg ctgtgaaggg     4500

ggtatgcaag cattgcccag agatgtgtca ggactgcatc catgagaaaa catgcaaaga     4560

gtgcacgcct gagttcttcc tgcacgatga tatgtgccac cagtcctgtc cccgtggctt     4620

ctatgcagac tcgcgccact gtgtcccctg ccataaagac tgtctggagt gcagtggccc     4680

caaagccgac gactgcgagc tctgtcttga gagttcctgg gtcctctatg atggactgtg     4740

cttggaggag tgtccagcag gaacctatta tgaaaaggag actaaggagt gcagagattg     4800

ccacaagtcc tgcttgacct gctcatcatc tgggacctgc accacctgtc agaaaggcct     4860

gatcatgaac cctcgtggga gctgcatggc caacgagaag tgctcaccct ccgagtactg     4920

ggatgaggat gctcccgggt gcaagccctg ccatgttaag tgcttccact gcatggggcc     4980

ggcggaggac cagtgtcaaa catgccccat gaacagcctt cttctcaaca caacctgtgt     5040

gaaggactgc ccagagggct attatgccga tgaggacagc aaccggtgtg cccactgcca     5100

cagctcttgc aggacatgtg aagggagaca cagcaggcag tgccactcct gccgaccggg     5160

ctggttccag ctaggaaaag agtgcctgct ccagtgcagg gaaggatatt acgcagacaa     5220

ctccactggc cggtgtgaga ggtgcaacag gagctgcaag gggtgccagg gcccacggcc     5280

cacagactgc ctgtcttgcg atagattttt ctttctgctc cgctccaaag gagagtgtca     5340

tcgctcctgc ccagaccatt actatgtaga gcaaagcaca cagacctgtg agagatgcca     5400

tccgacttgt gatcaatgca aaggaaaagg agcgttgaat tgtttatcct gtgtgtggag     5460

ttaccacctc atgggaggga tctgcacctc ggactgtctt gtgggggaat acagagtggg     5520

agagggagag aagtttaact gtgaaaaatg ccacgagagc tgcatggaat gcaagggacc     5580

aggggccaag aactgcacct tgtgccctgc caacctggtg ctgcacatgg acgacagcca     5640

ctgcctccac tgctgcaaca cctctgatcc ccccagtgcc caggagtgct gtgactgcca     5700

ggacaccacg gacgaatgca tccttcgaac aagcaaggtt aggcctgcaa ctgagcattt     5760

caagacagct ctgttcatca cctcctccat gatgctggtg cttctgctcg gggcagctgt     5820

ggtagtgtgg aagaaatctc gtggccgagt ccagccagca gcaaaggccg gctatgaaaa     5880

actggccgac cccaacaagt cttactcctc ctataagagc agctatagag agagcaccag     5940

ctttgaagag gatcaggtga ttgagtacag ggatcgggac tatgatgagg atgatgatga     6000

tgacatcgtc tacatgggcc aggatggcac agtctaccgg aaatttaaat atgggctgct     6060

ggatgacgat gacatagatg agctggaata tgatgacgag agttactcct actaccagta     6120

aacaggcact cccccaccaa caccaccatt ccactctcag gcatgcctgt gagcatcact     6180

gtttttggtt ttatccccac accaggctga tgtgtgagtt tttctatttg tcttctttaa     6240

ccatgagtcc aaccagaata tgtaagaatg atgaaatact ttgttcttct tttgagtggc     6300

taaactcaat taacagttcc tgttcaaccg taattgaaga gcaaggataa aattcagagg     6360

cattttcctc aaaataatgt gttaagacac aaaaatgaag gaagtgaaaa caaatgagat     6420

ttgtacaaac tcttctatgt gattttaaaa aaaggacagc agatctatag aaattctgtt     6480

tccgagctgc attgtggagg tgtctgctgc ctcctggtat tctaattttt ctttatctaa     6540

ttttggggat aatggaggta caaaggagtt gttggtttgg tggtgttttt cttcccttta     6600

gctgtcttta ggcagaaatt tgttttgtaa gggccaagaa aagagggctc ttatcaattg     6660

actccaggcc acccctggtg agcagaagag accacctggg ctgggctgct caggacctac     6720

ttgagataag ggaagaaaag agaaggtgca tcatagctga ggagccatga ggtcacccca     6780

ggccctagtt cctccgcagg aatccagagt cacaacaatt ctaaaggcag agcaagccca     6840

gcgagaaaga aataactgaa tttccaggaa ctgcactctc atgattttct gggtactttt     6900

cgcctgggag acatcagcta agacatcgaa taataaaaga aaaatggcag tgttaaccta     6960

acataaaatg gaataaaatg acaaacactt catccgctct aaaaaattca gagctttcct     7020

tcatcaacaa cccatcacaa aaccgtggac tctcaataga aagagttgga atagagtcta     7080

acatggaaaa aaaaaaatcc caatatgctg ctcacaagct gtactctagc tgctgaccag     7140

ccttccagca ctgctcatca ctatgatttt tgtttctaga cttcctaggc ttcctttttt     7200

ccattcttct gtcaagtgta ttcttggatt catgcaactg aggacagttt ttgtccagat     7260

tgtaacacag agaagggctc ttgctatgca aaatgatgtt ggcagggtct tacagatttc     7320

cttgtcaaaa tagaccttac aggcagtact agaaatggag caccagaaag caaaaatgac     7380

attttcagag aatgatgata attataatct attgcacacc tactaccaga taacaagcta     7440

agtaattccc ccccaaaaat gccccactta tccattttgg tacttaccat actcccatga     7500

ggttggtatt gctattattc tgttcttgta ggaaacctga ggcttacaag aggttaggta     7560

actagtccaa ggtcatgcaa agctcaacaa aattcaagaa aaaagaatga tcaccctaaa     7620

gcgtgtgttc ttataactat gctactgaaa taaggtggga aaataagcat cctaaatata     7680

attaaagtca tgcctattgt tttagtctat aatatcaatg ttatctttac taaattcatg     7740

gattttcttt ttttaacata atgtatcact gacacagaaa atctttatga agaagtcttc     7800

agtttactaa aggcttgtgc ttctttagag gaaagctctt aaaacagggt tgacaaacag     7860

tctctggaaa gagccagcta gtaagtacat taggctttct tggccagaaa gtctctgtca     7920

taaccactca gctctgctat tatagcatga atgcagctgg tacataacgg atgggtgagc     7980

tgtgcttcaa taaaacctta tttatggaca ctgacatttg aaattcaggt aattttcaca     8040

tattataaaa ttttattctt cttttgattt ttttcaacct tttaaaattt aaaaatgcaa     8100

aagctattct cagttcacag cattacaaga acaggtggtg ggtcagattt ggccaacagg     8160

ctgtactttg ctgactttat ctttaaaaca gttttcagag atcatacatg tacatgtatg     8220

atatgcctcc aaaaattttg atcatttaaa attatctcct tggccaggcg tggtggctca     8280

tacctctaat cctagcactt tgggagactg aggcaggcag atcacctgaa gtcaggagtt     8340

tgataccagc ttagccaaca tggtgaaacc ccatttctac taaaaataca ataaaaatct     8400

gggcatgttg gtgcacacct gtaatcccag ctactcagga ggctgaggca ggcaaatcac     8460

ttgagcccgg gaggcagagg ttgcagtgag cggagatggc accattgcac tccagcctgg     8520

gtgacagagc aagactccat ctcaaaaaat aagtaactaa ctaactaact aaataaataa     8580

ataaataaaa ttatctcctt gccaggactg ctggctcatg cctgtaatcc cagcactctg     8640

ggaggctaag gcaggaggat tgctgaccca ccacctgttc ttgagcccag gagttcgaca     8700

tcagccttgg acaacatagt gagactcccg tgtctacaaa aaatttaaaa attagccagg     8760

catggtggca agtgtctgta gtctcagcta ctcaggaggc taaggtggaa ggatcacttg     8820

aacccgggag gtcgaggctg cagtgagctg tgatcttgct attgcacttc agcctgaatg     8880

acagagctaa gaccctgact caaaataaat aaataacatt atctcttcaa aatgtatctg     8940

aagccctgat agttctactt tcaattctta gaaacatata aaaatatatg catgatagcc     9000

atcatatcaa tggaagactt tctcacctct gtggttgcag ttagcttaca aaaacgagca     9060

attttgctta tactgtgttg ttcatcttcc ttgttaattc taaagctctg atagactgag     9120

tttgacattt ctttctgtaa actggaaatt gttttctatg aaaaaaaaac tctatgatac     9180

acagttaaag attggttgag gttgagatga acttcaatac taagaaaaat tgtggtgttc     9240

ctctgtgtgg cctgcaatga aaagaaggct catgcttgtg tattgaggtt tgacatcttt     9300

ccttctttgt ttttagtcat gcaacgtcat tcttagatgg cttttgaata ctatgctaat     9360

gactatctaa atagataaat atgtgattgg aaaacaaagt caccttttag ttttctactt     9420

ggaaatatta agagaatcct tgtagactgg aaacacacca aaaggctggg taaagcatgg     9480

gaggttccag ttaatagaaa gtaattttaa aattggaaat aaaattaaat caagacca       9538


<210>  59
<211>  5052
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B-domain deleted FVIII Fc chain (S743/Q1638)

<400>  59
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctctcaaa acccaccagt cttgaaacgc catcaacggg aaataactcg tactactctt     2340

cagtcagatc aagaggaaat tgactatgat gataccatat cagttgaaat gaagaaggaa     2400

gattttgaca tttatgatga ggatgaaaat cagagccccc gcagctttca aaagaaaaca     2460

cgacactatt ttattgctgc agtggagagg ctctgggatt atgggatgag tagctcccca     2520

catgttctaa gaaacagggc tcagagtggc agtgtccctc agttcaagaa agttgttttc     2580

caggaattta ctgatggctc ctttactcag cccttatacc gtggagaact aaatgaacat     2640

ttgggactcc tggggccata tataagagca gaagttgaag ataatatcat ggtaactttc     2700

agaaatcagg cctctcgtcc ctattccttc tattctagcc ttatttctta tgaggaagat     2760

cagaggcaag gagcagaacc tagaaaaaac tttgtcaagc ctaatgaaac caaaacttac     2820

ttttggaaag tgcaacatca tatggcaccc actaaagatg agtttgactg caaagcctgg     2880

gcttatttct ctgatgttga cctggaaaaa gatgtgcact caggcctgat tggacccctt     2940

ctggtctgcc acactaacac actgaaccct gctcatggga gacaagtgac agtacaggaa     3000

tttgctctgt ttttcaccat ctttgatgag accaaaagct ggtacttcac tgaaaatatg     3060

gaaagaaact gcagggctcc ctgcaatatc cagatggaag atcccacttt taaagagaat     3120

tatcgcttcc atgcaatcaa tggctacata atggatacac tacctggctt agtaatggct     3180

caggatcaaa ggattcgatg gtatctgctc agcatgggca gcaatgaaaa catccattct     3240

attcatttca gtggacatgt gttcactgta cgaaaaaaag aggagtataa aatggcactg     3300

tacaatctct atccaggtgt ttttgagaca gtggaaatgt taccatccaa agctggaatt     3360

tggcgggtgg aatgccttat tggcgagcat ctacatgctg ggatgagcac actttttctg     3420

gtgtacagca ataagtgtca gactcccctg ggaatggctt ctggacacat tagagatttt     3480

cagattacag cttcaggaca atatggacag tgggccccaa agctggccag acttcattat     3540

tccggatcaa tcaatgcctg gagcaccaag gagccctttt cttggatcaa ggtggatctg     3600

ttggcaccaa tgattattca cggcatcaag acccagggtg cccgtcagaa gttctccagc     3660

ctctacatct ctcagtttat catcatgtat agtcttgatg ggaagaagtg gcagacttat     3720

cgaggaaatt ccactggaac cttaatggtc ttctttggca atgtggattc atctgggata     3780

aaacacaata tttttaaccc tccaattatt gctcgataca tccgtttgca cccaactcat     3840

tatagcattc gcagcactct tcgcatggag ttgatgggct gtgatttaaa tagttgcagc     3900

atgccattgg gaatggagag taaagcaata tcagatgcac agattactgc ttcatcctac     3960

tttaccaata tgtttgccac ctggtctcct tcaaaagctc gacttcacct ccaagggagg     4020

agtaatgcct ggagacctca ggtgaataat ccaaaagagt ggctgcaagt ggacttccag     4080

aagacaatga aagtcacagg agtaactact cagggagtaa aatctctgct taccagcatg     4140

tatgtgaagg agttcctcat ctccagcagt caagatggcc atcagtggac tctctttttt     4200

cagaatggca aagtaaaggt ttttcaggga aatcaagact ccttcacacc tgtggtgaac     4260

tctctagacc caccgttact gactcgctac cttcgaattc acccccagag ttgggtgcac     4320

cagattgccc tgaggatgga ggttctgggc tgcgaggcac aggacctcta cgacaaaact     4380

cacacatgcc caccgtgccc agctccagaa ctcctgggcg gaccgtcagt cttcctcttc     4440

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg     4500

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag     4560

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc     4620

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc     4680

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc     4740

cgagaaccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc     4800

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc     4860

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgttggactc cgacggctcc     4920

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     4980

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     5040

tctccgggta aa                                                         5052


<210>  60
<211>  1684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B-domain deleted FVIIIFc Chain (S743/Q1638)

<400>  60

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val Leu 
        755                 760                 765             


Lys Arg His Gln Arg Glu Ile Thr Arg Thr Thr Leu Gln Ser Asp Gln 
    770                 775                 780                 


Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Val Glu Met Lys Lys Glu 
785                 790                 795                 800 


Asp Phe Asp Ile Tyr Asp Glu Asp Glu Asn Gln Ser Pro Arg Ser Phe 
                805                 810                 815     


Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp 
            820                 825                 830         


Asp Tyr Gly Met Ser Ser Ser Pro His Val Leu Arg Asn Arg Ala Gln 
        835                 840                 845             


Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr 
    850                 855                 860                 


Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His 
865                 870                 875                 880 


Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile 
                885                 890                 895     


Met Val Thr Phe Arg Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser 
            900                 905                 910         


Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro Arg 
        915                 920                 925             


Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys Val 
    930                 935                 940                 


Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala Trp 
945                 950                 955                 960 


Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Val His Ser Gly Leu 
                965                 970                 975     


Ile Gly Pro Leu Leu Val Cys His Thr Asn Thr Leu Asn Pro Ala His 
            980                 985                 990         


Gly Arg Gln Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
        995                 1000                 1005             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1010                 1015                 1020             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1025                 1030                 1035             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Ile  Met Asp Thr 
    1040                 1045                 1050             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1055                 1060                 1065             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1070                 1075                 1080             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1085                 1090                 1095             


Ala Leu  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    1100                 1105                 1110             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val Glu Cys  Leu Ile Gly 
    1115                 1120                 1125             


Glu His  Leu His Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    1130                 1135                 1140             


Asn Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  His Ile Arg 
    1145                 1150                 1155             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    1160                 1165                 1170             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    1175                 1180                 1185             


Thr Lys  Glu Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    1190                 1195                 1200             


Met Ile  Ile His Gly Ile Lys  Thr Gln Gly Ala Arg  Gln Lys Phe 
    1205                 1210                 1215             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    1220                 1225                 1230             


Gly Lys  Lys Trp Gln Thr Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    1235                 1240                 1245             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    1250                 1255                 1260             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    1265                 1270                 1275             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    1280                 1285                 1290             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Ser Lys 
    1295                 1300                 1305             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Phe Thr Asn 
    1310                 1315                 1320             


Met Phe  Ala Thr Trp Ser Pro  Ser Lys Ala Arg Leu  His Leu Gln 
    1325                 1330                 1335             


Gly Arg  Ser Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    1340                 1345                 1350             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Val 
    1355                 1360                 1365             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    1370                 1375                 1380             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Gln  Trp Thr Leu 
    1385                 1390                 1395             


Phe Phe  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    1400                 1405                 1410             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    1415                 1420                 1425             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Val His  Gln Ile Ala 
    1430                 1435                 1440             


Leu Arg  Met Glu Val Leu Gly  Cys Glu Ala Gln Asp  Leu Tyr Asp 
    1445                 1450                 1455             


Lys Thr  His Thr Cys Pro Pro  Cys Pro Ala Pro Glu  Leu Leu Gly 
    1460                 1465                 1470             


Gly Pro  Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 
    1475                 1480                 1485             


Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 
    1490                 1495                 1500             


Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 
    1505                 1510                 1515             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 
    1520                 1525                 1530             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1535                 1540                 1545             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1550                 1555                 1560             


Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1565                 1570                 1575             


Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 
    1580                 1585                 1590             


Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1595                 1600                 1605             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1610                 1615                 1620             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1625                 1630                 1635             


Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 
    1640                 1645                 1650             


Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1655                 1660                 1665             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 
    1670                 1675                 1680             


Lys 
    


<210>  61
<211>  7734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length FVIIIFc chain

<400>  61
atgcaaatag agctctccac ctgcttcttt ctgtgccttt tgcgattctg ctttagtgcc       60

accagaagat actacctggg tgcagtggaa ctgtcatggg actatatgca aagtgatctc      120

ggtgagctgc ctgtggacgc aagatttcct cctagagtgc caaaatcttt tccattcaac      180

acctcagtcg tgtacaaaaa gactctgttt gtagaattca cggatcacct tttcaacatc      240

gctaagccaa ggccaccctg gatgggtctg ctaggtccta ccatccaggc tgaggtttat      300

gatacagtgg tcattacact taagaacatg gcttcccatc ctgtcagtct tcatgctgtt      360

ggtgtatcct actggaaagc ttctgaggga gctgaatatg atgatcagac cagtcaaagg      420

gagaaagaag atgataaagt cttccctggt ggaagccata catatgtctg gcaggtcctg      480

aaagagaatg gtccaatggc ctctgaccca ctgtgcctta cctactcata tctttctcat      540

gtggacctgg taaaagactt gaattcaggc ctcattggag ccctactagt atgtagagaa      600

gggagtctgg ccaaggaaaa gacacagacc ttgcacaaat ttatactact ttttgctgta      660

tttgatgaag ggaaaagttg gcactcagaa acaaagaact ccttgatgca ggatagggat      720

gctgcatctg ctcgggcctg gcctaaaatg cacacagtca atggttatgt aaacaggtct      780

ctgccaggtc tgattggatg ccacaggaaa tcagtctatt ggcatgtgat tggaatgggc      840

accactcctg aagtgcactc aatattcctc gaaggtcaca catttcttgt gaggaaccat      900

cgccaggcgt ccttggaaat ctcgccaata actttcctta ctgctcaaac actcttgatg      960

gaccttggac agtttctact gttttgtcat atctcttccc accaacatga tggcatggaa     1020

gcttatgtca aagtagacag ctgtccagag gaaccccaac tacgaatgaa aaataatgaa     1080

gaagcggaag actatgatga tgatcttact gattctgaaa tggatgtggt caggtttgat     1140

gatgacaact ctccttcctt tatccaaatt cgctcagttg ccaagaagca tcctaaaact     1200

tgggtacatt acattgctgc tgaagaggag gactgggact atgctccctt agtcctcgcc     1260

cccgatgaca gaagttataa aagtcaatat ttgaacaatg gccctcagcg gattggtagg     1320

aagtacaaaa aagtccgatt tatggcatac acagatgaaa cctttaagac tcgtgaagct     1380

attcagcatg aatcaggaat cttgggacct ttactttatg gggaagttgg agacacactg     1440

ttgattatat ttaagaatca agcaagcaga ccatataaca tctaccctca cggaatcact     1500

gatgtccgtc ctttgtattc aaggagatta ccaaaaggtg taaaacattt gaaggatttt     1560

ccaattctgc caggagaaat attcaaatat aaatggacag tgactgtaga agatgggcca     1620

actaaatcag atcctcggtg cctgacccgc tattactcta gtttcgttaa tatggagaga     1680

gatctagctt caggactcat tggccctctc ctcatctgct acaaagaatc tgtagatcaa     1740

agaggaaacc agataatgtc agacaagagg aatgtcatcc tgttttctgt atttgatgag     1800

aaccgaagct ggtacctcac agagaatata caacgctttc tccccaatcc agctggagtg     1860

cagcttgagg atccagagtt ccaagcctcc aacatcatgc acagcatcaa tggctatgtt     1920

tttgatagtt tgcagttgtc agtttgtttg catgaggtgg catactggta cattctaagc     1980

attggagcac agactgactt cctttctgtc ttcttctctg gatatacctt caaacacaaa     2040

atggtctatg aagacacact caccctattc ccattctcag gagaaactgt cttcatgtcg     2100

atggaaaacc caggtctatg gattctgggg tgccacaact cagactttcg gaacagaggc     2160

atgaccgcct tactgaaggt ttctagttgt gacaagaaca ctggtgatta ttacgaggac     2220

agttatgaag atatttcagc atacttgctg agtaaaaaca atgccattga accaagaagc     2280

ttctcccaga attcaagaca ccctagcact aggcaaaagc aatttaatgc caccacaatt     2340

ccagaaaatg acatagagaa gactgaccct tggtttgcac acagaacacc tatgcctaaa     2400

atacaaaatg tctcctctag tgatttgttg atgctcttgc gacagagtcc tactccacat     2460

gggctatcct tatctgatct ccaagaagcc aaatatgaga ctttttctga tgatccatca     2520

cctggagcaa tagacagtaa taacagcctg tctgaaatga cacacttcag gccacagctc     2580

catcacagtg gggacatggt atttacccct gagtcaggcc tccaattaag attaaatgag     2640

aaactgggga caactgcagc aacagagttg aagaaacttg atttcaaagt ttctagtaca     2700

tcaaataatc tgatttcaac aattccatca gacaatttgg cagcaggtac tgataataca     2760

agttccttag gacccccaag tatgccagtt cattatgata gtcaattaga taccactcta     2820

tttggcaaaa agtcatctcc ccttactgag tctggtggac ctctgagctt gagtgaagaa     2880

aataatgatt caaagttgtt agaatcaggt ttaatgaata gccaagaaag ttcatgggga     2940

aaaaatgtat cgtcaacaga gagtggtagg ttatttaaag ggaaaagagc tcatggacct     3000

gctttgttga ctaaagataa tgccttattc aaagttagca tctctttgtt aaagacaaac     3060

aaaacttcca ataattcagc aactaataga aagactcaca ttgatggccc atcattatta     3120

attgagaata gtccatcagt ctggcaaaat atattagaaa gtgacactga gtttaaaaaa     3180

gtgacacctt tgattcatga cagaatgctt atggacaaaa atgctacagc tttgaggcta     3240

aatcatatgt caaataaaac tacttcatca aaaaacatgg aaatggtcca acagaaaaaa     3300

gagggcccca ttccaccaga tgcacaaaat ccagatatgt cgttctttaa gatgctattc     3360

ttgccagaat cagcaaggtg gatacaaagg actcatggaa agaactctct gaactctggg     3420

caaggcccca gtccaaagca attagtatcc ttaggaccag aaaaatctgt ggaaggtcag     3480

aatttcttgt ctgagaaaaa caaagtggta gtaggaaagg gtgaatttac aaaggacgta     3540

ggactcaaag agatggtttt tccaagcagc agaaacctat ttcttactaa cttggataat     3600

ttacatgaaa ataatacaca caatcaagaa aaaaaaattc aggaagaaat agaaaagaag     3660

gaaacattaa tccaagagaa tgtagttttg cctcagatac atacagtgac tggcactaag     3720

aatttcatga agaacctttt cttactgagc actaggcaaa atgtagaagg ttcatatgac     3780

ggggcatatg ctccagtact tcaagatttt aggtcattaa atgattcaac aaatagaaca     3840

aagaaacaca cagctcattt ctcaaaaaaa ggggaggaag aaaacttgga aggcttggga     3900

aatcaaacca agcaaattgt agagaaatat gcatgcacca caaggatatc tcctaataca     3960

agccagcaga attttgtcac gcaacgtagt aagagagctt tgaaacaatt cagactccca     4020

ctagaagaaa cagaacttga aaaaaggata attgtggatg acacctcaac ccagtggtcc     4080

aaaaacatga aacatttgac cccgagcacc ctcacacaga tagactacaa tgagaaggag     4140

aaaggggcca ttactcagtc tcccttatca gattgcctta cgaggagtca tagcatccct     4200

caagcaaata gatctccatt acccattgca aaggtatcat catttccatc tattagacct     4260

atatatctga ccagggtcct attccaagac aactcttctc atcttccagc agcatcttat     4320

agaaagaaag attctggggt ccaagaaagc agtcatttct tacaaggagc caaaaaaaat     4380

aacctttctt tagccattct aaccttggag atgactggtg atcaaagaga ggttggctcc     4440

ctggggacaa gtgccacaaa ttcagtcaca tacaagaaag ttgagaacac tgttctcccg     4500

aaaccagact tgcccaaaac atctggcaaa gttgaattgc ttccaaaagt tcacatttat     4560

cagaaggacc tattccctac ggaaactagc aatgggtctc ctggccatct ggatctcgtg     4620

gaagggagcc ttcttcaggg aacagaggga gcgattaagt ggaatgaagc aaacagacct     4680

ggaaaagttc cctttctgag agtagcaaca gaaagctctg caaagactcc ctccaagcta     4740

ttggatcctc ttgcttggga taaccactat ggtactcaga taccaaaaga agagtggaaa     4800

tcccaagaga agtcaccaga aaaaacagct tttaagaaaa aggataccat tttgtccctg     4860

aacgcttgtg aaagcaatca tgcaatagca gcaataaatg agggacaaaa taagcccgaa     4920

atagaagtca cctgggcaaa gcaaggtagg actgaaaggc tgtgctctca aaacccacca     4980

gtcttgaaac gccatcaacg ggaaataact cgtactactc ttcagtcaga tcaagaggaa     5040

attgactatg atgataccat atcagttgaa atgaagaagg aagattttga catttatgat     5100

gaggatgaaa atcagagccc ccgcagcttt caaaagaaaa cacgacacta ttttattgct     5160

gcagtggaga ggctctggga ttatgggatg agtagctccc cacatgttct aagaaacagg     5220

gctcagagtg gcagtgtccc tcagttcaag aaagttgttt tccaggaatt tactgatggc     5280

tcctttactc agcccttata ccgtggagaa ctaaatgaac atttgggact cctggggcca     5340

tatataagag cagaagttga agataatatc atggtaactt tcagaaatca ggcctctcgt     5400

ccctattcct tctattctag ccttatttct tatgaggaag atcagaggca aggagcagaa     5460

cctagaaaaa actttgtcaa gcctaatgaa accaaaactt acttttggaa agtgcaacat     5520

catatggcac ccactaaaga tgagtttgac tgcaaagcct gggcttattt ctctgatgtt     5580

gacctggaaa aagatgtgca ctcaggcctg attggacccc ttctggtctg ccacactaac     5640

acactgaacc ctgctcatgg gagacaagtg acagtacagg aatttgctct gtttttcacc     5700

atctttgatg agaccaaaag ctggtacttc actgaaaata tggaaagaaa ctgcagggct     5760

ccctgcaata tccagatgga agatcccact tttaaagaga attatcgctt ccatgcaatc     5820

aatggctaca taatggatac actacctggc ttagtaatgg ctcaggatca aaggattcga     5880

tggtatctgc tcagcatggg cagcaatgaa aacatccatt ctattcattt cagtggacat     5940

gtgttcactg tacgaaaaaa agaggagtat aaaatggcac tgtacaatct ctatccaggt     6000

gtttttgaga cagtggaaat gttaccatcc aaagctggaa tttggcgggt ggaatgcctt     6060

attggcgagc atctacatgc tgggatgagc acactttttc tggtgtacag caataagtgt     6120

cagactcccc tgggaatggc ttctggacac attagagatt ttcagattac agcttcagga     6180

caatatggac agtgggcccc aaagctggcc agacttcatt attccggatc aatcaatgcc     6240

tggagcacca aggagccctt ttcttggatc aaggtggatc tgttggcacc aatgattatt     6300

cacggcatca agacccaggg tgcccgtcag aagttctcca gcctctacat ctctcagttt     6360

atcatcatgt atagtcttga tgggaagaag tggcagactt atcgaggaaa ttccactgga     6420

accttaatgg tcttctttgg caatgtggat tcatctggga taaaacacaa tatttttaac     6480

cctccaatta ttgctcgata catccgtttg cacccaactc attatagcat tcgcagcact     6540

cttcgcatgg agttgatggg ctgtgattta aatagttgca gcatgccatt gggaatggag     6600

agtaaagcaa tatcagatgc acagattact gcttcatcct actttaccaa tatgtttgcc     6660

acctggtctc cttcaaaagc tcgacttcac ctccaaggga ggagtaatgc ctggagacct     6720

caggtgaata atccaaaaga gtggctgcaa gtggacttcc agaagacaat gaaagtcaca     6780

ggagtaacta ctcagggagt aaaatctctg cttaccagca tgtatgtgaa ggagttcctc     6840

atctccagca gtcaagatgg ccatcagtgg actctctttt ttcagaatgg caaagtaaag     6900

gtttttcagg gaaatcaaga ctccttcaca cctgtggtga actctctaga cccaccgtta     6960

ctgactcgct accttcgaat tcacccccag agttgggtgc accagattgc cctgaggatg     7020

gaggttctgg gctgcgaggc acaggacctc tacgacaaaa ctcacacatg cccaccgtgc     7080

ccagctccag aactcctggg cggaccgtca gtcttcctct tccccccaaa acccaaggac     7140

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     7200

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     7260

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     7320

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     7380

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     7440

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     7500

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     7560

aactacaaga ccacgcctcc cgtgttggac tccgacggct ccttcttcct ctacagcaag     7620

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     7680

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa           7734


<210>  62
<211>  2578
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length FVIIIFc chain

<400>  62

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr Asp Lys Thr His  Thr Cys Pro 
    2345                 2350                 2355             


Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu 
    2360                 2365                 2370             


Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro 
    2375                 2380                 2385             


Glu Val  Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
    2390                 2395                 2400             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    2405                 2410                 2415             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    2420                 2425                 2430             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    2435                 2440                 2445             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    2450                 2455                 2460             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    2465                 2470                 2475             


Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 
    2480                 2485                 2490             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    2495                 2500                 2505             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    2510                 2515                 2520             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    2525                 2530                 2535             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    2540                 2545                 2550             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    2555                 2560                 2565             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    2570                 2575             


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  63

Gly Gly Ser Gly Gly Gly Gly Ser 
1               5               


