                         SEQUENCE LISTING

<110>  YU, JUNYING
       VODYANYK, MAKSYM A.
 
<120>  ENDOTHELIAL CELL PRODUCTION BY DIRECT  PROGRAMMING

<130>  CDIN.P0030WO

<140>  UNKNOWN
<141>  2011-07-07

<150>  61/362,085
<151>  2010-07-07

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  2
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  2

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  3

Ala Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Asn 
1               5                   10                  15      


Asn 
    


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  4

Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  5

Tyr Ala Arg Lys Ala Arg Arg Gln Ala Arg Arg 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  6

Tyr Ala Arg Ala Ala Arg Arg Ala Ala Arg Arg 
1               5                   10      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  7

Tyr Ala Arg Ala Ala Arg Arg Ala Ala Arg Ala 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  8

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  9
<211>  5042
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (273)..(1661)

<400>  9
gttttcactt ggtcggaatg gggagagtgt gcaagagatc gctgcgggac aggttcctag       60

agatcgctcc gggacggtcg tgacggcccc cgagggacat gagagaagag gagcggcgct      120

caggttattc caggatcttt ggagacccga ggaaagccgt gttgaccaaa agcaagacaa      180

atgactcaca gagaaaaaag atggcagaac caagggcaac taaagccgtc aggttctgaa      240

cagctggtag atgggctggc ttactgaagg ac atg att cag act gtc ccg gac        293
                                    Met Ile Gln Thr Val Pro Asp           
                                    1               5                     

cca gca gct cat atc aag gaa gcc tta tca gtt gtg agt gag gac cag        341
Pro Ala Ala His Ile Lys Glu Ala Leu Ser Val Val Ser Glu Asp Gln           
        10                  15                  20                        

tcg ttg ttt gag tgt gcc tac gga acg cca cac ctg gct aag aca gag        389
Ser Leu Phe Glu Cys Ala Tyr Gly Thr Pro His Leu Ala Lys Thr Glu           
    25                  30                  35                            

atg acc gcg tcc tcc tcc agc gac tat gga cag act tcc aag atg agc        437
Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys Met Ser           
40                  45                  50                  55            

cca cgc gtc cct cag cag gat tgg ctg tct caa ccc cca gcc agg gtc        485
Pro Arg Val Pro Gln Gln Asp Trp Leu Ser Gln Pro Pro Ala Arg Val           
                60                  65                  70                

acc atc aaa atg gaa tgt aac cct agc cag gtg aat ggc tca agg aac        533
Thr Ile Lys Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg Asn           
            75                  80                  85                    

tct cct gat gaa tgc agt gtg gcc aaa ggc ggg aag atg gtg ggc agc        581
Ser Pro Asp Glu Cys Ser Val Ala Lys Gly Gly Lys Met Val Gly Ser           
        90                  95                  100                       

cca gac acc gtt ggg atg aac tac ggc agc tac atg gag gag aag cac        629
Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met Glu Glu Lys His           
    105                 110                 115                           

atg cca ccc cca aac atg acc acg aac gag cgc aga gtt atc gtg cca        677
Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro           
120                 125                 130                 135           

gca gat cct acg cta tgg agt aca gac cat gtg cgg cag tgg ctg gag        725
Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg Gln Trp Leu Glu           
                140                 145                 150               

tgg gcg gtg aaa gaa tat ggc ctt cca gac gtc aac atc ttg tta ttc        773
Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn Ile Leu Leu Phe           
            155                 160                 165                   

cag aac atc gat ggg aag gaa ctg tgc aag atg acc aag gac gac ttc        821
Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr Lys Asp Asp Phe           
        170                 175                 180                       

cag agg ctc acc ccc agc tac aac gcc gac atc ctt ctc tca cat ctc        869
Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu Leu Ser His Leu           
    185                 190                 195                           

cac tac ctc aga gag act cct ctt cca cat ttg act tca gat gat gtt        917
His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp Val           
200                 205                 210                 215           

gat aaa gcc tta caa aac tct cca cgg tta atg cat gct aga aac aca        965
Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn Thr           
                220                 225                 230               

gat tta cca tat gag ccc ccc agg aga tca gcc tgg acc ggt cac ggc       1013
Asp Leu Pro Tyr Glu Pro Pro Arg Arg Ser Ala Trp Thr Gly His Gly           
            235                 240                 245                   

cac ccc acg ccc cag tcg aaa gct gct caa cca tct cct tcc aca gtg       1061
His Pro Thr Pro Gln Ser Lys Ala Ala Gln Pro Ser Pro Ser Thr Val           
        250                 255                 260                       

ccc aaa act gaa gac cag cgt cct cag tta gat cct tat cag att ctt       1109
Pro Lys Thr Glu Asp Gln Arg Pro Gln Leu Asp Pro Tyr Gln Ile Leu           
    265                 270                 275                           

gga cca aca agt agc cgc ctt gca aat cca ggc agt ggc cag atc cag       1157
Gly Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln           
280                 285                 290                 295           

ctt tgg cag ttc ctc ctg gag ctc ctg tcg gac agc tcc aac tcc agc       1205
Leu Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ser Asn Ser Ser           
                300                 305                 310               

tgc atc acc tgg gaa ggc acc aac ggg gag ttc aag atg acg gat ccc       1253
Cys Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro           
            315                 320                 325                   

gac gag gtg gcc cgg cgc tgg gga gag cgg aag agc aaa ccc aac atg       1301
Asp Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met           
        330                 335                 340                       

aac tac gat aag ctc agc cgc gcc ctc cgt tac tac tat gac aag aac       1349
Asn Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn           
    345                 350                 355                           

atc atg acc aag gtc cat ggg aag cgc tac gcc tac aag ttc gac ttc       1397
Ile Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe           
360                 365                 370                 375           

cac ggg atc gcc cag gcc ctc cag ccc cac ccc ccg gag tca tct ctg       1445
His Gly Ile Ala Gln Ala Leu Gln Pro His Pro Pro Glu Ser Ser Leu           
                380                 385                 390               

tac aag tac ccc tca gac ctc ccg tac atg ggc tcc tat cac gcc cac       1493
Tyr Lys Tyr Pro Ser Asp Leu Pro Tyr Met Gly Ser Tyr His Ala His           
            395                 400                 405                   

cca cag aag atg aac ttt gtg gcg ccc cac cct cca gcc ctc ccc gtg       1541
Pro Gln Lys Met Asn Phe Val Ala Pro His Pro Pro Ala Leu Pro Val           
        410                 415                 420                       

aca tct tcc agt ttt ttt gct gcc cca aac cca tac tgg aat tca cca       1589
Thr Ser Ser Ser Phe Phe Ala Ala Pro Asn Pro Tyr Trp Asn Ser Pro           
    425                 430                 435                           

act ggg ggt ata tac ccc aac act agg ctc ccc acc agc cat atg cct       1637
Thr Gly Gly Ile Tyr Pro Asn Thr Arg Leu Pro Thr Ser His Met Pro           
440                 445                 450                 455           

tct cat ctg ggc act tac tac taa agacctggcg gaggcttttc ccatcagcgt      1691
Ser His Leu Gly Thr Tyr Tyr                                               
                460                                                       

gcattcacca gcccatcgcc acaaactcta tcggagaaca tgaatcaaaa gtgcctcaag     1751

aggaatgaaa aaagctttac tggggctggg gaaggaagcc ggggaagaga tccaaagact     1811

cttgggaggg agttactgaa gtcttactac agaaatgagg aggatgctaa aaatgtcacg     1871

aatatggaca tatcatctgt ggactgacct tgtaaaagac agtgtatgta gaagcatgaa     1931

gtcttaagga caaagtgcca aagaaagtgg tcttaagaaa tgtataaact ttagagtaga     1991

gtttggaatc ccactaatgc aaactgggat gaaactaaag caatagaaac aacacagttt     2051

tgacctaaca taccgtttat aatgccattt taaggaaaac tacctgtatt taaaaataga     2111

aacatatcaa aaacaagaga aaagacacga gagagactgt ggcccatcaa cagacgttga     2171

tatgcaactg catggcatgt gctgttttgg ttgaaatcaa atacattccg tttgatggac     2231

agctgtcagc tttctcaaac tgtgaagatg acccaaagtt tccaactcct ttacagtatt     2291

accgggacta tgaactaaaa ggtgggactg aggatgtgta tagagtgagc gtgtgattgt     2351

agacagaggg gtgaagaagg aggaggaaga ggcagagaag gaggagacca gggctgggaa     2411

agaaacttct caagcaatga agactggact caggacattt ggggactgtg tacaatgagt     2471

tatggagact cgagggttca tgcagtcagt gttataccaa acccagtgtt aggagaaagg     2531

acacagcgta atggagaaag gggaagtagt agaattcaga aacaaaaatg cgcatctctt     2591

tctttgtttg tcaaatgaaa attttaactg gaattgtctg atatttaaga gaaacattca     2651

ggacctcatc attatgtggg ggctttgttc tccacagggt caggtaagag atggccttct     2711

tggctgccac aatcagaaat cacgcaggca ttttgggtag gcggcctcca gttttccttt     2771

gagtcgcgaa cgctgtgcgt ttgtcagaat gaagtataca agtcaatgtt tttccccctt     2831

tttatataat aattatataa cttatgcatt tatacactac gagttgatct cggccagcca     2891

aagacacacg acaaaagaga caatcgatat aatgtggcct tgaattttaa ctctgtatgc     2951

ttaatgttta caatatgaag ttattagttc ttagaatgca gaatgtatgt aataaaataa     3011

gcttggccta gcatggcaaa tcagatttat acaggagtct gcatttgcac tttttttagt     3071

gactaaagtt gcttaatgaa aacatgtgct gaatgttgtg gattttgtgt tataatttac     3131

tttgtccagg aacttgtgca agggagagcc aaggaaatag gatgtttggc acccaaatgg     3191

cgtcagcctc tccaggtcct tcttgcctcc cctcctgtct tttatttcta gccccttttg     3251

gaacagaagg accccgggtt tcacattgga gcctccatat ttatgcctgg aatggaaaga     3311

ggcctatgaa gctggggttg tcattgagaa attctagttc agcacctggt cacaaatcac     3371

ccttaattcc tgctatgatt aaaatacatt tgttgaacag tgaacaagct accactcgta     3431

aggcaaactg tattattact ggcaaataaa gcgtcatgga tagctgcaat ttctcacttt     3491

acagaaacaa gggataacgt ctagatttgc tgcggggttt ctctttcagg agctctcact     3551

aggtagacag ctttagtcct gctacatcag agttacctgg gcactgtggc ttgggattca     3611

ctagccctga gcctgatgtt gctggctatc ccttgaagac aatgtttatt tccataatct     3671

agagtcagtt tccctgggca tcttttcttt gaatcacaaa tgctgccaac cttggtccag     3731

gtgaaggcaa ctcaaaaggt gaaaatacaa ggtgaccgtg cgaaggcgct agccgaaaca     3791

tcttagctga ataggtttct gaactggccc ttttcatagc tgtttcaggg cctgtttttt     3851

tcacgttgca gtccttttgc tatgattatg tgaagttgcc aaacctctgt gctgtggatg     3911

ttttggcagt gggctttgaa gtcggcagga cacgattacc aatgctcctg acaccccgtg     3971

tcatttggat tagacggagc ccaaccatcc atcattttgc agcagcctgg gaaggcccac     4031

aaagtgcccg tatctcctta gggaaaataa ataaatacaa tcatgaaagc tggcagttag     4091

gctgacccaa actgtgctaa tggaaaagat cagtcatttt tattttggaa tgcaaagtca     4151

agacacacct acattcttca tagaaataca catttacttg gataatcact cagttctctc     4211

ttcaagactg tctcatgagc aagatcataa aaacaagaca tgattatcat attcaatttt     4271

aacagatgtt ttccattaga tccctcaacc ctccaccccc agtccaggtt attagcaagt     4331

cttatgagca actgggataa ttttggataa catgataata ctgagttcct tcaaatacat     4391

aattcttaaa ttgtttcaaa atggcattaa ctctctgtta ctgttgtaat ctaattccaa     4451

agccccctcc aggtcatatt cataattgca tgaacctttt ctctctgttt gtccctgtct     4511

cttggcttgc cctgatgtat actcagactc ctgtacaatc ttactcctgc tggcaagaga     4571

tttgtcttct tttcttgtct tcaattggct ttcgggcctt gtatgtggta aaatcaccaa     4631

atcacagtca agactgtgtt tttgttccta gtttgatgcc cttatgtccc ggaggggttc     4691

acaaagtgct ttgtcaggac tgctgcagtt agaaggctca ctgcttctcc taagccttct     4751

gcacagatgt ggcacctgca acccaggagc aggagccgga ggagctgccc tctgacagca     4811

ggtgcagcag agatggctac agctcaggag ctgggaaggt gatggggcac agggaaagca     4871

cagatgttct gcagcgcccc aaagtgaccc attgcctgga gaaagagaag aaaatatttt     4931

ttaaaaagct agtttattta gcttctcatt aattcattca aataaagtcg tgaggtgact     4991

aattagagaa taaaaattac tttggactac tcaaaaatac accaaaaaaa a              5042


<210>  10
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu 
1               5                   10                  15      


Ser Val Val Ser Glu Asp Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr 
            20                  25                  30          


Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu 
    50                  55                  60                  


Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser 
65                  70                  75                  80  


Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys 
                85                  90                  95      


Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly 
            100                 105                 110         


Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn 
        115                 120                 125             


Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp 
    130                 135                 140                 


His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro 
145                 150                 155                 160 


Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys 
                165                 170                 175     


Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala 
            180                 185                 190         


Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro 
        195                 200                 205             


His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg 
    210                 215                 220                 


Leu Met His Ala Arg Asn Thr Asp Leu Pro Tyr Glu Pro Pro Arg Arg 
225                 230                 235                 240 


Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala Ala 
                245                 250                 255     


Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro Gln 
            260                 265                 270         


Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala Asn 
        275                 280                 285             


Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu 
    290                 295                 300                 


Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn Gly 
305                 310                 315                 320 


Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly Glu 
                325                 330                 335     


Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala Leu 
            340                 345                 350         


Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys Arg 
        355                 360                 365             


Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln Pro 
    370                 375                 380                 


His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro Tyr 
385                 390                 395                 400 


Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala Pro 
                405                 410                 415     


His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala Pro 
            420                 425                 430         


Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr Arg 
        435                 440                 445             


Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr 
    450                 455                 460         


<210>  11
<211>  5114
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (273)..(1733)

<400>  11
gttttcactt ggtcggaatg gggagagtgt gcaagagatc gctgcgggac aggttcctag       60

agatcgctcc gggacggtcg tgacggcccc cgagggacat gagagaagag gagcggcgct      120

caggttattc caggatcttt ggagacccga ggaaagccgt gttgaccaaa agcaagacaa      180

atgactcaca gagaaaaaag atggcagaac caagggcaac taaagccgtc aggttctgaa      240

cagctggtag atgggctggc ttactgaagg ac atg att cag act gtc ccg gac        293
                                    Met Ile Gln Thr Val Pro Asp           
                                    1               5                     

cca gca gct cat atc aag gaa gcc tta tca gtt gtg agt gag gac cag        341
Pro Ala Ala His Ile Lys Glu Ala Leu Ser Val Val Ser Glu Asp Gln           
        10                  15                  20                        

tcg ttg ttt gag tgt gcc tac gga acg cca cac ctg gct aag aca gag        389
Ser Leu Phe Glu Cys Ala Tyr Gly Thr Pro His Leu Ala Lys Thr Glu           
    25                  30                  35                            

atg acc gcg tcc tcc tcc agc gac tat gga cag act tcc aag atg agc        437
Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys Met Ser           
40                  45                  50                  55            

cca cgc gtc cct cag cag gat tgg ctg tct caa ccc cca gcc agg gtc        485
Pro Arg Val Pro Gln Gln Asp Trp Leu Ser Gln Pro Pro Ala Arg Val           
                60                  65                  70                

acc atc aaa atg gaa tgt aac cct agc cag gtg aat ggc tca agg aac        533
Thr Ile Lys Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg Asn           
            75                  80                  85                    

tct cct gat gaa tgc agt gtg gcc aaa ggc ggg aag atg gtg ggc agc        581
Ser Pro Asp Glu Cys Ser Val Ala Lys Gly Gly Lys Met Val Gly Ser           
        90                  95                  100                       

cca gac acc gtt ggg atg aac tac ggc agc tac atg gag gag aag cac        629
Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met Glu Glu Lys His           
    105                 110                 115                           

atg cca ccc cca aac atg acc acg aac gag cgc aga gtt atc gtg cca        677
Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro           
120                 125                 130                 135           

gca gat cct acg cta tgg agt aca gac cat gtg cgg cag tgg ctg gag        725
Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg Gln Trp Leu Glu           
                140                 145                 150               

tgg gcg gtg aaa gaa tat ggc ctt cca gac gtc aac atc ttg tta ttc        773
Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn Ile Leu Leu Phe           
            155                 160                 165                   

cag aac atc gat ggg aag gaa ctg tgc aag atg acc aag gac gac ttc        821
Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr Lys Asp Asp Phe           
        170                 175                 180                       

cag agg ctc acc ccc agc tac aac gcc gac atc ctt ctc tca cat ctc        869
Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu Leu Ser His Leu           
    185                 190                 195                           

cac tac ctc aga gag act cct ctt cca cat ttg act tca gat gat gtt        917
His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp Val           
200                 205                 210                 215           

gat aaa gcc tta caa aac tct cca cgg tta atg cat gct aga aac aca        965
Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn Thr           
                220                 225                 230               

ggg ggt gca gct ttt att ttc cca aat act tca gta tat cct gaa gct       1013
Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser Val Tyr Pro Glu Ala           
            235                 240                 245                   

acg caa aga att aca act agg cca gat tta cca tat gag ccc ccc agg       1061
Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro Tyr Glu Pro Pro Arg           
        250                 255                 260                       

aga tca gcc tgg acc ggt cac ggc cac ccc acg ccc cag tcg aaa gct       1109
Arg Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala           
    265                 270                 275                           

gct caa cca tct cct tcc aca gtg ccc aaa act gaa gac cag cgt cct       1157
Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro           
280                 285                 290                 295           

cag tta gat cct tat cag att ctt gga cca aca agt agc cgc ctt gca       1205
Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala           
                300                 305                 310               

aat cca ggc agt ggc cag atc cag ctt tgg cag ttc ctc ctg gag ctc       1253
Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu           
            315                 320                 325                   

ctg tcg gac agc tcc aac tcc agc tgc atc acc tgg gaa ggc acc aac       1301
Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn           
        330                 335                 340                       

ggg gag ttc aag atg acg gat ccc gac gag gtg gcc cgg cgc tgg gga       1349
Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly           
    345                 350                 355                           

gag cgg aag agc aaa ccc aac atg aac tac gat aag ctc agc cgc gcc       1397
Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala           
360                 365                 370                 375           

ctc cgt tac tac tat gac aag aac atc atg acc aag gtc cat ggg aag       1445
Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys           
                380                 385                 390               

cgc tac gcc tac aag ttc gac ttc cac ggg atc gcc cag gcc ctc cag       1493
Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln           
            395                 400                 405                   

ccc cac ccc ccg gag tca tct ctg tac aag tac ccc tca gac ctc ccg       1541
Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro           
        410                 415                 420                       

tac atg ggc tcc tat cac gcc cac cca cag aag atg aac ttt gtg gcg       1589
Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala           
    425                 430                 435                           

ccc cac cct cca gcc ctc ccc gtg aca tct tcc agt ttt ttt gct gcc       1637
Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala           
440                 445                 450                 455           

cca aac cca tac tgg aat tca cca act ggg ggt ata tac ccc aac act       1685
Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr           
                460                 465                 470               

agg ctc ccc acc agc cat atg cct tct cat ctg ggc act tac tac taa       1733
Arg Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr               
            475                 480                 485                   

agacctggcg gaggcttttc ccatcagcgt gcattcacca gcccatcgcc acaaactcta     1793

tcggagaaca tgaatcaaaa gtgcctcaag aggaatgaaa aaagctttac tggggctggg     1853

gaaggaagcc ggggaagaga tccaaagact cttgggaggg agttactgaa gtcttactac     1913

agaaatgagg aggatgctaa aaatgtcacg aatatggaca tatcatctgt ggactgacct     1973

tgtaaaagac agtgtatgta gaagcatgaa gtcttaagga caaagtgcca aagaaagtgg     2033

tcttaagaaa tgtataaact ttagagtaga gtttggaatc ccactaatgc aaactgggat     2093

gaaactaaag caatagaaac aacacagttt tgacctaaca taccgtttat aatgccattt     2153

taaggaaaac tacctgtatt taaaaataga aacatatcaa aaacaagaga aaagacacga     2213

gagagactgt ggcccatcaa cagacgttga tatgcaactg catggcatgt gctgttttgg     2273

ttgaaatcaa atacattccg tttgatggac agctgtcagc tttctcaaac tgtgaagatg     2333

acccaaagtt tccaactcct ttacagtatt accgggacta tgaactaaaa ggtgggactg     2393

aggatgtgta tagagtgagc gtgtgattgt agacagaggg gtgaagaagg aggaggaaga     2453

ggcagagaag gaggagacca gggctgggaa agaaacttct caagcaatga agactggact     2513

caggacattt ggggactgtg tacaatgagt tatggagact cgagggttca tgcagtcagt     2573

gttataccaa acccagtgtt aggagaaagg acacagcgta atggagaaag gggaagtagt     2633

agaattcaga aacaaaaatg cgcatctctt tctttgtttg tcaaatgaaa attttaactg     2693

gaattgtctg atatttaaga gaaacattca ggacctcatc attatgtggg ggctttgttc     2753

tccacagggt caggtaagag atggccttct tggctgccac aatcagaaat cacgcaggca     2813

ttttgggtag gcggcctcca gttttccttt gagtcgcgaa cgctgtgcgt ttgtcagaat     2873

gaagtataca agtcaatgtt tttccccctt tttatataat aattatataa cttatgcatt     2933

tatacactac gagttgatct cggccagcca aagacacacg acaaaagaga caatcgatat     2993

aatgtggcct tgaattttaa ctctgtatgc ttaatgttta caatatgaag ttattagttc     3053

ttagaatgca gaatgtatgt aataaaataa gcttggccta gcatggcaaa tcagatttat     3113

acaggagtct gcatttgcac tttttttagt gactaaagtt gcttaatgaa aacatgtgct     3173

gaatgttgtg gattttgtgt tataatttac tttgtccagg aacttgtgca agggagagcc     3233

aaggaaatag gatgtttggc acccaaatgg cgtcagcctc tccaggtcct tcttgcctcc     3293

cctcctgtct tttatttcta gccccttttg gaacagaagg accccgggtt tcacattgga     3353

gcctccatat ttatgcctgg aatggaaaga ggcctatgaa gctggggttg tcattgagaa     3413

attctagttc agcacctggt cacaaatcac ccttaattcc tgctatgatt aaaatacatt     3473

tgttgaacag tgaacaagct accactcgta aggcaaactg tattattact ggcaaataaa     3533

gcgtcatgga tagctgcaat ttctcacttt acagaaacaa gggataacgt ctagatttgc     3593

tgcggggttt ctctttcagg agctctcact aggtagacag ctttagtcct gctacatcag     3653

agttacctgg gcactgtggc ttgggattca ctagccctga gcctgatgtt gctggctatc     3713

ccttgaagac aatgtttatt tccataatct agagtcagtt tccctgggca tcttttcttt     3773

gaatcacaaa tgctgccaac cttggtccag gtgaaggcaa ctcaaaaggt gaaaatacaa     3833

ggtgaccgtg cgaaggcgct agccgaaaca tcttagctga ataggtttct gaactggccc     3893

ttttcatagc tgtttcaggg cctgtttttt tcacgttgca gtccttttgc tatgattatg     3953

tgaagttgcc aaacctctgt gctgtggatg ttttggcagt gggctttgaa gtcggcagga     4013

cacgattacc aatgctcctg acaccccgtg tcatttggat tagacggagc ccaaccatcc     4073

atcattttgc agcagcctgg gaaggcccac aaagtgcccg tatctcctta gggaaaataa     4133

ataaatacaa tcatgaaagc tggcagttag gctgacccaa actgtgctaa tggaaaagat     4193

cagtcatttt tattttggaa tgcaaagtca agacacacct acattcttca tagaaataca     4253

catttacttg gataatcact cagttctctc ttcaagactg tctcatgagc aagatcataa     4313

aaacaagaca tgattatcat attcaatttt aacagatgtt ttccattaga tccctcaacc     4373

ctccaccccc agtccaggtt attagcaagt cttatgagca actgggataa ttttggataa     4433

catgataata ctgagttcct tcaaatacat aattcttaaa ttgtttcaaa atggcattaa     4493

ctctctgtta ctgttgtaat ctaattccaa agccccctcc aggtcatatt cataattgca     4553

tgaacctttt ctctctgttt gtccctgtct cttggcttgc cctgatgtat actcagactc     4613

ctgtacaatc ttactcctgc tggcaagaga tttgtcttct tttcttgtct tcaattggct     4673

ttcgggcctt gtatgtggta aaatcaccaa atcacagtca agactgtgtt tttgttccta     4733

gtttgatgcc cttatgtccc ggaggggttc acaaagtgct ttgtcaggac tgctgcagtt     4793

agaaggctca ctgcttctcc taagccttct gcacagatgt ggcacctgca acccaggagc     4853

aggagccgga ggagctgccc tctgacagca ggtgcagcag agatggctac agctcaggag     4913

ctgggaaggt gatggggcac agggaaagca cagatgttct gcagcgcccc aaagtgaccc     4973

attgcctgga gaaagagaag aaaatatttt ttaaaaagct agtttattta gcttctcatt     5033

aattcattca aataaagtcg tgaggtgact aattagagaa taaaaattac tttggactac     5093

tcaaaaatac accaaaaaaa a                                               5114


<210>  12
<211>  486
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ile Gln Thr Val Pro Asp Pro Ala Ala His Ile Lys Glu Ala Leu 
1               5                   10                  15      


Ser Val Val Ser Glu Asp Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr 
            20                  25                  30          


Pro His Leu Ala Lys Thr Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr 
        35                  40                  45              


Gly Gln Thr Ser Lys Met Ser Pro Arg Val Pro Gln Gln Asp Trp Leu 
    50                  55                  60                  


Ser Gln Pro Pro Ala Arg Val Thr Ile Lys Met Glu Cys Asn Pro Ser 
65                  70                  75                  80  


Gln Val Asn Gly Ser Arg Asn Ser Pro Asp Glu Cys Ser Val Ala Lys 
                85                  90                  95      


Gly Gly Lys Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly 
            100                 105                 110         


Ser Tyr Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn 
        115                 120                 125             


Glu Arg Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp 
    130                 135                 140                 


His Val Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro 
145                 150                 155                 160 


Asp Val Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys 
                165                 170                 175     


Lys Met Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala 
            180                 185                 190         


Asp Ile Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro 
        195                 200                 205             


His Leu Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg 
    210                 215                 220                 


Leu Met His Ala Arg Asn Thr Gly Gly Ala Ala Phe Ile Phe Pro Asn 
225                 230                 235                 240 


Thr Ser Val Tyr Pro Glu Ala Thr Gln Arg Ile Thr Thr Arg Pro Asp 
                245                 250                 255     


Leu Pro Tyr Glu Pro Pro Arg Arg Ser Ala Trp Thr Gly His Gly His 
            260                 265                 270         


Pro Thr Pro Gln Ser Lys Ala Ala Gln Pro Ser Pro Ser Thr Val Pro 
        275                 280                 285             


Lys Thr Glu Asp Gln Arg Pro Gln Leu Asp Pro Tyr Gln Ile Leu Gly 
    290                 295                 300                 


Pro Thr Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu 
305                 310                 315                 320 


Trp Gln Phe Leu Leu Glu Leu Leu Ser Asp Ser Ser Asn Ser Ser Cys 
                325                 330                 335     


Ile Thr Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp 
            340                 345                 350         


Glu Val Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn 
        355                 360                 365             


Tyr Asp Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile 
    370                 375                 380                 


Met Thr Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His 
385                 390                 395                 400 


Gly Ile Ala Gln Ala Leu Gln Pro His Pro Pro Glu Ser Ser Leu Tyr 
                405                 410                 415     


Lys Tyr Pro Ser Asp Leu Pro Tyr Met Gly Ser Tyr His Ala His Pro 
            420                 425                 430         


Gln Lys Met Asn Phe Val Ala Pro His Pro Pro Ala Leu Pro Val Thr 
        435                 440                 445             


Ser Ser Ser Phe Phe Ala Ala Pro Asn Pro Tyr Trp Asn Ser Pro Thr 
    450                 455                 460                 


Gly Gly Ile Tyr Pro Asn Thr Arg Leu Pro Thr Ser His Met Pro Ser 
465                 470                 475                 480 


His Leu Gly Thr Tyr Tyr 
                485     


<210>  13
<211>  4945
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (125)..(1564)

<400>  13
ttcatttccc agacttagca caatctcatc cgctctaaac aacctcatca aaactacttt       60

ctggtcagag agaagcaata attattatta acatttatta acgatcaata aacttgatcg      120

catt atg gcc agc act att aag gaa gcc tta tca gtt gtg agt gag gac       169
     Met Ala Ser Thr Ile Lys Glu Ala Leu Ser Val Val Ser Glu Asp          
     1               5                   10                  15           

cag tcg ttg ttt gag tgt gcc tac gga acg cca cac ctg gct aag aca        217
Gln Ser Leu Phe Glu Cys Ala Tyr Gly Thr Pro His Leu Ala Lys Thr           
                20                  25                  30                

gag atg acc gcg tcc tcc tcc agc gac tat gga cag act tcc aag atg        265
Glu Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys Met           
            35                  40                  45                    

agc cca cgc gtc cct cag cag gat tgg ctg tct caa ccc cca gcc agg        313
Ser Pro Arg Val Pro Gln Gln Asp Trp Leu Ser Gln Pro Pro Ala Arg           
        50                  55                  60                        

gtc acc atc aaa atg gaa tgt aac cct agc cag gtg aat ggc tca agg        361
Val Thr Ile Lys Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg           
    65                  70                  75                            

aac tct cct gat gaa tgc agt gtg gcc aaa ggc ggg aag atg gtg ggc        409
Asn Ser Pro Asp Glu Cys Ser Val Ala Lys Gly Gly Lys Met Val Gly           
80                  85                  90                  95            

agc cca gac acc gtt ggg atg aac tac ggc agc tac atg gag gag aag        457
Ser Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met Glu Glu Lys           
                100                 105                 110               

cac atg cca ccc cca aac atg acc acg aac gag cgc aga gtt atc gtg        505
His Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val           
            115                 120                 125                   

cca gca gat cct acg cta tgg agt aca gac cat gtg cgg cag tgg ctg        553
Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg Gln Trp Leu           
        130                 135                 140                       

gag tgg gcg gtg aaa gaa tat ggc ctt cca gac gtc aac atc ttg tta        601
Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn Ile Leu Leu           
    145                 150                 155                           

ttc cag aac atc gat ggg aag gaa ctg tgc aag atg acc aag gac gac        649
Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr Lys Asp Asp           
160                 165                 170                 175           

ttc cag agg ctc acc ccc agc tac aac gcc gac atc ctt ctc tca cat        697
Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu Leu Ser His           
                180                 185                 190               

ctc cac tac ctc aga gag act cct ctt cca cat ttg act tca gat gat        745
Leu His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp           
            195                 200                 205                   

gtt gat aaa gcc tta caa aac tct cca cgg tta atg cat gct aga aac        793
Val Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn           
        210                 215                 220                       

aca ggg ggt gca gct ttt att ttc cca aat act tca gta tat cct gaa        841
Thr Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser Val Tyr Pro Glu           
    225                 230                 235                           

gct acg caa aga att aca act agg cca gat tta cca tat gag ccc ccc        889
Ala Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro Tyr Glu Pro Pro           
240                 245                 250                 255           

agg aga tca gcc tgg acc ggt cac ggc cac ccc acg ccc cag tcg aaa        937
Arg Arg Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys           
                260                 265                 270               

gct gct caa cca tct cct tcc aca gtg ccc aaa act gaa gac cag cgt        985
Ala Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg           
            275                 280                 285                   

cct cag tta gat cct tat cag att ctt gga cca aca agt agc cgc ctt       1033
Pro Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu           
        290                 295                 300                       

gca aat cca ggc agt ggc cag atc cag ctt tgg cag ttc ctc ctg gag       1081
Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu           
    305                 310                 315                           

ctc ctg tcg gac agc tcc aac tcc agc tgc atc acc tgg gaa ggc acc       1129
Leu Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr           
320                 325                 330                 335           

aac ggg gag ttc aag atg acg gat ccc gac gag gtg gcc cgg cgc tgg       1177
Asn Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp           
                340                 345                 350               

gga gag cgg aag agc aaa ccc aac atg aac tac gat aag ctc agc cgc       1225
Gly Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg           
            355                 360                 365                   

gcc ctc cgt tac tac tat gac aag aac atc atg acc aag gtc cat ggg       1273
Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly           
        370                 375                 380                       

aag cgc tac gcc tac aag ttc gac ttc cac ggg atc gcc cag gcc ctc       1321
Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu           
    385                 390                 395                           

cag ccc cac ccc ccg gag tca tct ctg tac aag tac ccc tca gac ctc       1369
Gln Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu           
400                 405                 410                 415           

ccg tac atg ggc tcc tat cac gcc cac cca cag aag atg aac ttt gtg       1417
Pro Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val           
                420                 425                 430               

gcg ccc cac cct cca gcc ctc ccc gtg aca tct tcc agt ttt ttt gct       1465
Ala Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala           
            435                 440                 445                   

gcc cca aac cca tac tgg aat tca cca act ggg ggt ata tac ccc aac       1513
Ala Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn           
        450                 455                 460                       

act agg ctc ccc acc agc cat atg cct tct cat ctg ggc act tac tac       1561
Thr Arg Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr           
    465                 470                 475                           

taa agacctggcg gaggcttttc ccatcagcgt gcattcacca gcccatcgcc            1614

acaaactcta tcggagaaca tgaatcaaaa gtgcctcaag aggaatgaaa aaagctttac     1674

tggggctggg gaaggaagcc ggggaagaga tccaaagact cttgggaggg agttactgaa     1734

gtcttactac agaaatgagg aggatgctaa aaatgtcacg aatatggaca tatcatctgt     1794

ggactgacct tgtaaaagac agtgtatgta gaagcatgaa gtcttaagga caaagtgcca     1854

aagaaagtgg tcttaagaaa tgtataaact ttagagtaga gtttggaatc ccactaatgc     1914

aaactgggat gaaactaaag caatagaaac aacacagttt tgacctaaca taccgtttat     1974

aatgccattt taaggaaaac tacctgtatt taaaaataga aacatatcaa aaacaagaga     2034

aaagacacga gagagactgt ggcccatcaa cagacgttga tatgcaactg catggcatgt     2094

gctgttttgg ttgaaatcaa atacattccg tttgatggac agctgtcagc tttctcaaac     2154

tgtgaagatg acccaaagtt tccaactcct ttacagtatt accgggacta tgaactaaaa     2214

ggtgggactg aggatgtgta tagagtgagc gtgtgattgt agacagaggg gtgaagaagg     2274

aggaggaaga ggcagagaag gaggagacca gggctgggaa agaaacttct caagcaatga     2334

agactggact caggacattt ggggactgtg tacaatgagt tatggagact cgagggttca     2394

tgcagtcagt gttataccaa acccagtgtt aggagaaagg acacagcgta atggagaaag     2454

gggaagtagt agaattcaga aacaaaaatg cgcatctctt tctttgtttg tcaaatgaaa     2514

attttaactg gaattgtctg atatttaaga gaaacattca ggacctcatc attatgtggg     2574

ggctttgttc tccacagggt caggtaagag atggccttct tggctgccac aatcagaaat     2634

cacgcaggca ttttgggtag gcggcctcca gttttccttt gagtcgcgaa cgctgtgcgt     2694

ttgtcagaat gaagtataca agtcaatgtt tttccccctt tttatataat aattatataa     2754

cttatgcatt tatacactac gagttgatct cggccagcca aagacacacg acaaaagaga     2814

caatcgatat aatgtggcct tgaattttaa ctctgtatgc ttaatgttta caatatgaag     2874

ttattagttc ttagaatgca gaatgtatgt aataaaataa gcttggccta gcatggcaaa     2934

tcagatttat acaggagtct gcatttgcac tttttttagt gactaaagtt gcttaatgaa     2994

aacatgtgct gaatgttgtg gattttgtgt tataatttac tttgtccagg aacttgtgca     3054

agggagagcc aaggaaatag gatgtttggc acccaaatgg cgtcagcctc tccaggtcct     3114

tcttgcctcc cctcctgtct tttatttcta gccccttttg gaacagaagg accccgggtt     3174

tcacattgga gcctccatat ttatgcctgg aatggaaaga ggcctatgaa gctggggttg     3234

tcattgagaa attctagttc agcacctggt cacaaatcac ccttaattcc tgctatgatt     3294

aaaatacatt tgttgaacag tgaacaagct accactcgta aggcaaactg tattattact     3354

ggcaaataaa gcgtcatgga tagctgcaat ttctcacttt acagaaacaa gggataacgt     3414

ctagatttgc tgcggggttt ctctttcagg agctctcact aggtagacag ctttagtcct     3474

gctacatcag agttacctgg gcactgtggc ttgggattca ctagccctga gcctgatgtt     3534

gctggctatc ccttgaagac aatgtttatt tccataatct agagtcagtt tccctgggca     3594

tcttttcttt gaatcacaaa tgctgccaac cttggtccag gtgaaggcaa ctcaaaaggt     3654

gaaaatacaa ggtgaccgtg cgaaggcgct agccgaaaca tcttagctga ataggtttct     3714

gaactggccc ttttcatagc tgtttcaggg cctgtttttt tcacgttgca gtccttttgc     3774

tatgattatg tgaagttgcc aaacctctgt gctgtggatg ttttggcagt gggctttgaa     3834

gtcggcagga cacgattacc aatgctcctg acaccccgtg tcatttggat tagacggagc     3894

ccaaccatcc atcattttgc agcagcctgg gaaggcccac aaagtgcccg tatctcctta     3954

gggaaaataa ataaatacaa tcatgaaagc tggcagttag gctgacccaa actgtgctaa     4014

tggaaaagat cagtcatttt tattttggaa tgcaaagtca agacacacct acattcttca     4074

tagaaataca catttacttg gataatcact cagttctctc ttcaagactg tctcatgagc     4134

aagatcataa aaacaagaca tgattatcat attcaatttt aacagatgtt ttccattaga     4194

tccctcaacc ctccaccccc agtccaggtt attagcaagt cttatgagca actgggataa     4254

ttttggataa catgataata ctgagttcct tcaaatacat aattcttaaa ttgtttcaaa     4314

atggcattaa ctctctgtta ctgttgtaat ctaattccaa agccccctcc aggtcatatt     4374

cataattgca tgaacctttt ctctctgttt gtccctgtct cttggcttgc cctgatgtat     4434

actcagactc ctgtacaatc ttactcctgc tggcaagaga tttgtcttct tttcttgtct     4494

tcaattggct ttcgggcctt gtatgtggta aaatcaccaa atcacagtca agactgtgtt     4554

tttgttccta gtttgatgcc cttatgtccc ggaggggttc acaaagtgct ttgtcaggac     4614

tgctgcagtt agaaggctca ctgcttctcc taagccttct gcacagatgt ggcacctgca     4674

acccaggagc aggagccgga ggagctgccc tctgacagca ggtgcagcag agatggctac     4734

agctcaggag ctgggaaggt gatggggcac agggaaagca cagatgttct gcagcgcccc     4794

aaagtgaccc attgcctgga gaaagagaag aaaatatttt ttaaaaagct agtttattta     4854

gcttctcatt aattcattca aataaagtcg tgaggtgact aattagagaa taaaaattac     4914

tttggactac tcaaaaatac accaaaaaaa a                                    4945


<210>  14
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Thr Ile Lys Glu Ala Leu Ser Val Val Ser Glu Asp Gln 
1               5                   10                  15      


Ser Leu Phe Glu Cys Ala Tyr Gly Thr Pro His Leu Ala Lys Thr Glu 
            20                  25                  30          


Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys Met Ser 
        35                  40                  45              


Pro Arg Val Pro Gln Gln Asp Trp Leu Ser Gln Pro Pro Ala Arg Val 
    50                  55                  60                  


Thr Ile Lys Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg Asn 
65                  70                  75                  80  


Ser Pro Asp Glu Cys Ser Val Ala Lys Gly Gly Lys Met Val Gly Ser 
                85                  90                  95      


Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met Glu Glu Lys His 
            100                 105                 110         


Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro 
        115                 120                 125             


Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg Gln Trp Leu Glu 
    130                 135                 140                 


Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn Ile Leu Leu Phe 
145                 150                 155                 160 


Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr Lys Asp Asp Phe 
                165                 170                 175     


Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu Leu Ser His Leu 
            180                 185                 190         


His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp Val 
        195                 200                 205             


Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn Thr 
    210                 215                 220                 


Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser Val Tyr Pro Glu Ala 
225                 230                 235                 240 


Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro Tyr Glu Pro Pro Arg 
                245                 250                 255     


Arg Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala 
            260                 265                 270         


Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro 
        275                 280                 285             


Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala 
    290                 295                 300                 


Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
305                 310                 315                 320 


Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn 
                325                 330                 335     


Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
            340                 345                 350         


Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala 
        355                 360                 365             


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys 
    370                 375                 380                 


Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln 
385                 390                 395                 400 


Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro 
                405                 410                 415     


Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala 
            420                 425                 430         


Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala 
        435                 440                 445             


Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr 
    450                 455                 460                 


Arg Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr 
465                 470                 475                 


<210>  15
<211>  4727
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (183)..(1346)

<400>  15
ttcatttccc agacttagca caatctcatc cgctctaaac aacctcatca aaactacttt       60

ctggtcagag agaagcaata attattatta acatttatta acgatcaata aacttgatcg      120

cattatggcc agcactatta aggaactctc ctgatgaatg cagtgtggcc aaaggcggga      180

ag atg gtg ggc agc cca gac acc gtt ggg atg aac tac ggc agc tac         227
   Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr            
   1               5                   10                  15             

atg gag gag aag cac atg cca ccc cca aac atg acc acg aac gag cgc        275
Met Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg           
                20                  25                  30                

aga gtt atc gtg cca gca gat cct acg cta tgg agt aca gac cat gtg        323
Arg Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val           
            35                  40                  45                    

cgg cag tgg ctg gag tgg gcg gtg aaa gaa tat ggc ctt cca gac gtc        371
Arg Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val           
        50                  55                  60                        

aac atc ttg tta ttc cag aac atc gat ggg aag gaa ctg tgc aag atg        419
Asn Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met           
    65                  70                  75                            

acc aag gac gac ttc cag agg ctc acc ccc agc tac aac gcc gac atc        467
Thr Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile           
80                  85                  90                  95            

ctt ctc tca cat ctc cac tac ctc aga gag act cct ctt cca cat ttg        515
Leu Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu           
                100                 105                 110               

act tca gat gat gtt gat aaa gcc tta caa aac tct cca cgg tta atg        563
Thr Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met           
            115                 120                 125                   

cat gct aga aac aca ggg ggt gca gct ttt att ttc cca aat act tca        611
His Ala Arg Asn Thr Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser           
        130                 135                 140                       

gta tat cct gaa gct acg caa aga att aca act agg cca gat tta cca        659
Val Tyr Pro Glu Ala Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro           
    145                 150                 155                           

tat gag ccc ccc agg aga tca gcc tgg acc ggt cac ggc cac ccc acg        707
Tyr Glu Pro Pro Arg Arg Ser Ala Trp Thr Gly His Gly His Pro Thr           
160                 165                 170                 175           

ccc cag tcg aaa gct gct caa cca tct cct tcc aca gtg ccc aaa act        755
Pro Gln Ser Lys Ala Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr           
                180                 185                 190               

gaa gac cag cgt cct cag tta gat cct tat cag att ctt gga cca aca        803
Glu Asp Gln Arg Pro Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr           
            195                 200                 205                   

agt agc cgc ctt gca aat cca ggc agt ggc cag atc cag ctt tgg cag        851
Ser Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln           
        210                 215                 220                       

ttc ctc ctg gag ctc ctg tcg gac agc tcc aac tcc agc tgc atc acc        899
Phe Leu Leu Glu Leu Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr           
    225                 230                 235                           

tgg gaa ggc acc aac ggg gag ttc aag atg acg gat ccc gac gag gtg        947
Trp Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val           
240                 245                 250                 255           

gcc cgg cgc tgg gga gag cgg aag agc aaa ccc aac atg aac tac gat        995
Ala Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp           
                260                 265                 270               

aag ctc agc cgc gcc ctc cgt tac tac tat gac aag aac atc atg acc       1043
Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr           
            275                 280                 285                   

aag gtc cat ggg aag cgc tac gcc tac aag ttc gac ttc cac ggg atc       1091
Lys Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile           
        290                 295                 300                       

gcc cag gcc ctc cag ccc cac ccc ccg gag tca tct ctg tac aag tac       1139
Ala Gln Ala Leu Gln Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr           
    305                 310                 315                           

ccc tca gac ctc ccg tac atg ggc tcc tat cac gcc cac cca cag aag       1187
Pro Ser Asp Leu Pro Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys           
320                 325                 330                 335           

atg aac ttt gtg gcg ccc cac cct cca gcc ctc ccc gtg aca tct tcc       1235
Met Asn Phe Val Ala Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser           
                340                 345                 350               

agt ttt ttt gct gcc cca aac cca tac tgg aat tca cca act ggg ggt       1283
Ser Phe Phe Ala Ala Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly           
            355                 360                 365                   

ata tac ccc aac act agg ctc ccc acc agc cat atg cct tct cat ctg       1331
Ile Tyr Pro Asn Thr Arg Leu Pro Thr Ser His Met Pro Ser His Leu           
        370                 375                 380                       

ggc act tac tac taa agacctggcg gaggcttttc ccatcagcgt gcattcacca       1386
Gly Thr Tyr Tyr                                                           
    385                                                                   

gcccatcgcc acaaactcta tcggagaaca tgaatcaaaa gtgcctcaag aggaatgaaa     1446

aaagctttac tggggctggg gaaggaagcc ggggaagaga tccaaagact cttgggaggg     1506

agttactgaa gtcttactac agaaatgagg aggatgctaa aaatgtcacg aatatggaca     1566

tatcatctgt ggactgacct tgtaaaagac agtgtatgta gaagcatgaa gtcttaagga     1626

caaagtgcca aagaaagtgg tcttaagaaa tgtataaact ttagagtaga gtttggaatc     1686

ccactaatgc aaactgggat gaaactaaag caatagaaac aacacagttt tgacctaaca     1746

taccgtttat aatgccattt taaggaaaac tacctgtatt taaaaataga aacatatcaa     1806

aaacaagaga aaagacacga gagagactgt ggcccatcaa cagacgttga tatgcaactg     1866

catggcatgt gctgttttgg ttgaaatcaa atacattccg tttgatggac agctgtcagc     1926

tttctcaaac tgtgaagatg acccaaagtt tccaactcct ttacagtatt accgggacta     1986

tgaactaaaa ggtgggactg aggatgtgta tagagtgagc gtgtgattgt agacagaggg     2046

gtgaagaagg aggaggaaga ggcagagaag gaggagacca gggctgggaa agaaacttct     2106

caagcaatga agactggact caggacattt ggggactgtg tacaatgagt tatggagact     2166

cgagggttca tgcagtcagt gttataccaa acccagtgtt aggagaaagg acacagcgta     2226

atggagaaag gggaagtagt agaattcaga aacaaaaatg cgcatctctt tctttgtttg     2286

tcaaatgaaa attttaactg gaattgtctg atatttaaga gaaacattca ggacctcatc     2346

attatgtggg ggctttgttc tccacagggt caggtaagag atggccttct tggctgccac     2406

aatcagaaat cacgcaggca ttttgggtag gcggcctcca gttttccttt gagtcgcgaa     2466

cgctgtgcgt ttgtcagaat gaagtataca agtcaatgtt tttccccctt tttatataat     2526

aattatataa cttatgcatt tatacactac gagttgatct cggccagcca aagacacacg     2586

acaaaagaga caatcgatat aatgtggcct tgaattttaa ctctgtatgc ttaatgttta     2646

caatatgaag ttattagttc ttagaatgca gaatgtatgt aataaaataa gcttggccta     2706

gcatggcaaa tcagatttat acaggagtct gcatttgcac tttttttagt gactaaagtt     2766

gcttaatgaa aacatgtgct gaatgttgtg gattttgtgt tataatttac tttgtccagg     2826

aacttgtgca agggagagcc aaggaaatag gatgtttggc acccaaatgg cgtcagcctc     2886

tccaggtcct tcttgcctcc cctcctgtct tttatttcta gccccttttg gaacagaagg     2946

accccgggtt tcacattgga gcctccatat ttatgcctgg aatggaaaga ggcctatgaa     3006

gctggggttg tcattgagaa attctagttc agcacctggt cacaaatcac ccttaattcc     3066

tgctatgatt aaaatacatt tgttgaacag tgaacaagct accactcgta aggcaaactg     3126

tattattact ggcaaataaa gcgtcatgga tagctgcaat ttctcacttt acagaaacaa     3186

gggataacgt ctagatttgc tgcggggttt ctctttcagg agctctcact aggtagacag     3246

ctttagtcct gctacatcag agttacctgg gcactgtggc ttgggattca ctagccctga     3306

gcctgatgtt gctggctatc ccttgaagac aatgtttatt tccataatct agagtcagtt     3366

tccctgggca tcttttcttt gaatcacaaa tgctgccaac cttggtccag gtgaaggcaa     3426

ctcaaaaggt gaaaatacaa ggtgaccgtg cgaaggcgct agccgaaaca tcttagctga     3486

ataggtttct gaactggccc ttttcatagc tgtttcaggg cctgtttttt tcacgttgca     3546

gtccttttgc tatgattatg tgaagttgcc aaacctctgt gctgtggatg ttttggcagt     3606

gggctttgaa gtcggcagga cacgattacc aatgctcctg acaccccgtg tcatttggat     3666

tagacggagc ccaaccatcc atcattttgc agcagcctgg gaaggcccac aaagtgcccg     3726

tatctcctta gggaaaataa ataaatacaa tcatgaaagc tggcagttag gctgacccaa     3786

actgtgctaa tggaaaagat cagtcatttt tattttggaa tgcaaagtca agacacacct     3846

acattcttca tagaaataca catttacttg gataatcact cagttctctc ttcaagactg     3906

tctcatgagc aagatcataa aaacaagaca tgattatcat attcaatttt aacagatgtt     3966

ttccattaga tccctcaacc ctccaccccc agtccaggtt attagcaagt cttatgagca     4026

actgggataa ttttggataa catgataata ctgagttcct tcaaatacat aattcttaaa     4086

ttgtttcaaa atggcattaa ctctctgtta ctgttgtaat ctaattccaa agccccctcc     4146

aggtcatatt cataattgca tgaacctttt ctctctgttt gtccctgtct cttggcttgc     4206

cctgatgtat actcagactc ctgtacaatc ttactcctgc tggcaagaga tttgtcttct     4266

tttcttgtct tcaattggct ttcgggcctt gtatgtggta aaatcaccaa atcacagtca     4326

agactgtgtt tttgttccta gtttgatgcc cttatgtccc ggaggggttc acaaagtgct     4386

ttgtcaggac tgctgcagtt agaaggctca ctgcttctcc taagccttct gcacagatgt     4446

ggcacctgca acccaggagc aggagccgga ggagctgccc tctgacagca ggtgcagcag     4506

agatggctac agctcaggag ctgggaaggt gatggggcac agggaaagca cagatgttct     4566

gcagcgcccc aaagtgaccc attgcctgga gaaagagaag aaaatatttt ttaaaaagct     4626

agtttattta gcttctcatt aattcattca aataaagtcg tgaggtgact aattagagaa     4686

taaaaattac tttggactac tcaaaaatac accaaaaaaa a                         4727


<210>  16
<211>  387
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Val Gly Ser Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met 
1               5                   10                  15      


Glu Glu Lys His Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg 
            20                  25                  30          


Val Ile Val Pro Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg 
        35                  40                  45              


Gln Trp Leu Glu Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn 
    50                  55                  60                  


Ile Leu Leu Phe Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr 
65                  70                  75                  80  


Lys Asp Asp Phe Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu 
                85                  90                  95      


Leu Ser His Leu His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr 
            100                 105                 110         


Ser Asp Asp Val Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His 
        115                 120                 125             


Ala Arg Asn Thr Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser Val 
    130                 135                 140                 


Tyr Pro Glu Ala Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro Tyr 
145                 150                 155                 160 


Glu Pro Pro Arg Arg Ser Ala Trp Thr Gly His Gly His Pro Thr Pro 
                165                 170                 175     


Gln Ser Lys Ala Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu 
            180                 185                 190         


Asp Gln Arg Pro Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser 
        195                 200                 205             


Ser Arg Leu Ala Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe 
    210                 215                 220                 


Leu Leu Glu Leu Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp 
225                 230                 235                 240 


Glu Gly Thr Asn Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala 
                245                 250                 255     


Arg Arg Trp Gly Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys 
            260                 265                 270         


Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys 
        275                 280                 285             


Val His Gly Lys Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala 
    290                 295                 300                 


Gln Ala Leu Gln Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro 
305                 310                 315                 320 


Ser Asp Leu Pro Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys Met 
                325                 330                 335     


Asn Phe Val Ala Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser 
            340                 345                 350         


Phe Phe Ala Ala Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile 
        355                 360                 365             


Tyr Pro Asn Thr Arg Leu Pro Thr Ser His Met Pro Ser His Leu Gly 
    370                 375                 380                 


Thr Tyr Tyr 
385         


<210>  17
<211>  1490
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (440)..(1468)

<400>  17
gcagataagc ccagcttagc ccagctgacc ccagaccctc tcccctcact ccccccatgt       60

cgcaggatcg agaccctgag gcagacagcc cgttcaccaa gccccccgcc ccgcccccat      120

caccccgtaa acttctccca gcctccgccc tgccctcacc cagcccgctg ttccccaagc      180

ctcgctccaa gcccacgcca cccctgcagc agggcagccc cagaggccag cacctatccc      240

cgaggctggg gtcgaggctc ggccccgccc ctgcctctgc aacttgagcc tggctgcgac      300

ccctgctctg acgtctcgga aaattccccc ttgcccaggc ccttggggga gggggtgcat      360

ggtatgaaat ggggctgaga cccccggctg ggggcagagg aacccgccag agaacattca      420

gaaggccttc atcgcatcc atg gac ctg tgg aac tgg gat gag gca tcc cca       472
                     Met Asp Leu Trp Asn Trp Asp Glu Ala Ser Pro          
                     1               5                   10               

cag gaa gtg cct cca ggg aac aag ctg gca ggg ctt gaa gga gcc aaa        520
Gln Glu Val Pro Pro Gly Asn Lys Leu Ala Gly Leu Glu Gly Ala Lys           
            15                  20                  25                    

tta ggc ttc tgt ttc cct gat ctg gca ctc caa ggg gac acg ccg aca        568
Leu Gly Phe Cys Phe Pro Asp Leu Ala Leu Gln Gly Asp Thr Pro Thr           
        30                  35                  40                        

gcg aca gca gag aca tgc tgg aaa ggt aca agc tca tcc ctg gca agc        616
Ala Thr Ala Glu Thr Cys Trp Lys Gly Thr Ser Ser Ser Leu Ala Ser           
    45                  50                  55                            

ttc cca cag ctg gac tgg ggc tcc gcg tta ctg cac cca gaa gtt cca        664
Phe Pro Gln Leu Asp Trp Gly Ser Ala Leu Leu His Pro Glu Val Pro           
60                  65                  70                  75            

tgg ggg gcg gag ccc gac tct cag gct ctt ccg tgg tcc ggg gac tgg        712
Trp Gly Ala Glu Pro Asp Ser Gln Ala Leu Pro Trp Ser Gly Asp Trp           
                80                  85                  90                

aca gac atg gcg tgc aca gcc tgg gac tct tgg agc ggc gcc tcg cag        760
Thr Asp Met Ala Cys Thr Ala Trp Asp Ser Trp Ser Gly Ala Ser Gln           
            95                  100                 105                   

acc ctg ggc ccc gcc cct ctc ggc ccg ggc ccc atc ccc gcc gcc ggc        808
Thr Leu Gly Pro Ala Pro Leu Gly Pro Gly Pro Ile Pro Ala Ala Gly           
        110                 115                 120                       

tcc gaa ggc gcc gcg ggc cag aac tgc gtc ccc gtg gcg gga gag gcc        856
Ser Glu Gly Ala Ala Gly Gln Asn Cys Val Pro Val Ala Gly Glu Ala           
    125                 130                 135                           

acc tcg tgg tcg cgc gcc cag gcc gcc ggg agc aac acc agc tgg gac        904
Thr Ser Trp Ser Arg Ala Gln Ala Ala Gly Ser Asn Thr Ser Trp Asp           
140                 145                 150                 155           

tgt tct gtg ggg ccc gac ggc gat acc tac tgg ggc agt ggc ctg ggc        952
Cys Ser Val Gly Pro Asp Gly Asp Thr Tyr Trp Gly Ser Gly Leu Gly           
                160                 165                 170               

ggg gag ccg cgc acg gac tgt acc att tcg tgg ggc ggg ccc gcg ggc       1000
Gly Glu Pro Arg Thr Asp Cys Thr Ile Ser Trp Gly Gly Pro Ala Gly           
            175                 180                 185                   

ccg gac tgt acc acc tcc tgg aac ccg ggg ctg cat gcg ggt ggc acc       1048
Pro Asp Cys Thr Thr Ser Trp Asn Pro Gly Leu His Ala Gly Gly Thr           
        190                 195                 200                       

acc tct ttg aag cgg tac cag agc tca gct ctc acc gtt tgc tcc gaa       1096
Thr Ser Leu Lys Arg Tyr Gln Ser Ser Ala Leu Thr Val Cys Ser Glu           
    205                 210                 215                           

ccg agc ccg cag tcg gac cgt gcc agt ttg gct cga tgc ccc aaa act       1144
Pro Ser Pro Gln Ser Asp Arg Ala Ser Leu Ala Arg Cys Pro Lys Thr           
220                 225                 230                 235           

aac cac cga ggt ccc att cag ctg tgg cag ttc ctc ctg gag ctg ctc       1192
Asn His Arg Gly Pro Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu           
                240                 245                 250               

cac gac ggg gcg cgt agc agc tgc atc cgt tgg act ggc aac agc cgc       1240
His Asp Gly Ala Arg Ser Ser Cys Ile Arg Trp Thr Gly Asn Ser Arg           
            255                 260                 265                   

gag ttc cag ctg tgc gac ccc aaa gag gtg gct cgg ctg tgg ggc gag       1288
Glu Phe Gln Leu Cys Asp Pro Lys Glu Val Ala Arg Leu Trp Gly Glu           
        270                 275                 280                       

cgc aag aga aag ccg ggc atg aat tac gag aag ctg agc cgg ggc ctt       1336
Arg Lys Arg Lys Pro Gly Met Asn Tyr Glu Lys Leu Ser Arg Gly Leu           
    285                 290                 295                           

cgc tac tac tat cgc cgc gac atc gtg cgc aag agc ggg ggg cga aag       1384
Arg Tyr Tyr Tyr Arg Arg Asp Ile Val Arg Lys Ser Gly Gly Arg Lys           
300                 305                 310                 315           

tac acg tac cgc ttc ggg ggc cgc gtg ccc agc cta gcc tat ccg gac       1432
Tyr Thr Tyr Arg Phe Gly Gly Arg Val Pro Ser Leu Ala Tyr Pro Asp           
                320                 325                 330               

tgt gcg gga ggc gga cgg gga gca gag aca caa taa aaattcccgg            1478
Cys Ala Gly Gly Gly Arg Gly Ala Glu Thr Gln                               
            335                 340                                       

tcaaacctca aa                                                         1490


<210>  18
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Leu Trp Asn Trp Asp Glu Ala Ser Pro Gln Glu Val Pro Pro 
1               5                   10                  15      


Gly Asn Lys Leu Ala Gly Leu Glu Gly Ala Lys Leu Gly Phe Cys Phe 
            20                  25                  30          


Pro Asp Leu Ala Leu Gln Gly Asp Thr Pro Thr Ala Thr Ala Glu Thr 
        35                  40                  45              


Cys Trp Lys Gly Thr Ser Ser Ser Leu Ala Ser Phe Pro Gln Leu Asp 
    50                  55                  60                  


Trp Gly Ser Ala Leu Leu His Pro Glu Val Pro Trp Gly Ala Glu Pro 
65                  70                  75                  80  


Asp Ser Gln Ala Leu Pro Trp Ser Gly Asp Trp Thr Asp Met Ala Cys 
                85                  90                  95      


Thr Ala Trp Asp Ser Trp Ser Gly Ala Ser Gln Thr Leu Gly Pro Ala 
            100                 105                 110         


Pro Leu Gly Pro Gly Pro Ile Pro Ala Ala Gly Ser Glu Gly Ala Ala 
        115                 120                 125             


Gly Gln Asn Cys Val Pro Val Ala Gly Glu Ala Thr Ser Trp Ser Arg 
    130                 135                 140                 


Ala Gln Ala Ala Gly Ser Asn Thr Ser Trp Asp Cys Ser Val Gly Pro 
145                 150                 155                 160 


Asp Gly Asp Thr Tyr Trp Gly Ser Gly Leu Gly Gly Glu Pro Arg Thr 
                165                 170                 175     


Asp Cys Thr Ile Ser Trp Gly Gly Pro Ala Gly Pro Asp Cys Thr Thr 
            180                 185                 190         


Ser Trp Asn Pro Gly Leu His Ala Gly Gly Thr Thr Ser Leu Lys Arg 
        195                 200                 205             


Tyr Gln Ser Ser Ala Leu Thr Val Cys Ser Glu Pro Ser Pro Gln Ser 
    210                 215                 220                 


Asp Arg Ala Ser Leu Ala Arg Cys Pro Lys Thr Asn His Arg Gly Pro 
225                 230                 235                 240 


Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu His Asp Gly Ala Arg 
                245                 250                 255     


Ser Ser Cys Ile Arg Trp Thr Gly Asn Ser Arg Glu Phe Gln Leu Cys 
            260                 265                 270         


Asp Pro Lys Glu Val Ala Arg Leu Trp Gly Glu Arg Lys Arg Lys Pro 
        275                 280                 285             


Gly Met Asn Tyr Glu Lys Leu Ser Arg Gly Leu Arg Tyr Tyr Tyr Arg 
    290                 295                 300                 


Arg Asp Ile Val Arg Lys Ser Gly Gly Arg Lys Tyr Thr Tyr Arg Phe 
305                 310                 315                 320 


Gly Gly Arg Val Pro Ser Leu Ala Tyr Pro Asp Cys Ala Gly Gly Gly 
                325                 330                 335     


Arg Gly Ala Glu Thr Gln 
            340         


