                               SEQUENCE LISTING	

<110> MOUNT SINAI SCHOOL OF MEDICINE
 
<120> COMPOSITIONS AND METHODS FOR INHIBITING ONCOGENIC MICRORNAS AND 
      TREATMENT OF CANCER

<130> 27527-0076WO1

<140>
<141>

<150> 61/359,770
<151> 2010-06-29

<160> 101   

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> RNA
<213> Homo sapiens

<400> 1
aucgugcauc ccuuuagagu gu                                                22


<210> 2
<211> 22
<212> RNA
<213> Homo sapiens

<400> 2
aucgugcauc cuuuuagagu gu                                                22


<210> 3
<211> 22
<212> RNA
<213> Homo sapiens

<400> 3
ucgugcaucc cuuuagagug uu                                                22


<210> 4
<211> 24
<212> RNA
<213> Homo sapiens

<400> 4
acaaagugcu ucccuuuaga gugu                                              24


<210> 5
<211> 22
<212> RNA
<213> Homo sapiens

<400> 5
acaaagugcu ucccuuuaga gu                                                22


<210> 6
<211> 22
<212> RNA
<213> Homo sapiens

<400> 6
aaagugcauc cuuuuagagg uu                                                22


<210> 7
<211> 22
<212> RNA
<213> Homo sapiens

<400> 7
caaagugccu cccuuuagag ug                                                22


<210> 8
<211> 23
<212> RNA
<213> Homo sapiens

<400> 8
uucucgagga aagaagcacu uuc                                               23


<210> 9
<211> 22
<212> RNA
<213> Homo sapiens

<400> 9
aaagugcauc cuuuuagagu gu                                                22


<210> 10
<211> 22
<212> RNA
<213> Homo sapiens

<400> 10
aaagugcuuc cuuuuagagg gu                                                22


<210> 11
<211> 21
<212> RNA
<213> Homo sapiens

<400> 11
aaagugcuuc cuuuuagagg g                                                 21


<210> 12
<211> 22
<212> RNA
<213> Homo sapiens

<400> 12
aagugcuucc uuuuagaggg uu                                                22


<210> 13
<211> 22
<212> RNA
<213> Homo sapiens

<400> 13
gaaagugcuu ccuuuuagag gc                                                22


<210> 14
<211> 22
<212> RNA
<213> Homo sapiens

<400> 14
cuacaaaggg aagcacuuuc uc                                                22


<210> 15
<211> 18
<212> RNA
<213> Homo sapiens

<400> 15
ugcuuccuuu cagagggu                                                     18


<210> 16
<211> 23
<212> RNA
<213> Homo sapiens

<400> 16
cucuugaggg aagcacuuuc ugu                                               23


<210> 17
<211> 22
<212> RNA
<213> Homo sapiens

<400> 17
aagugccucc uuuuagagug uu                                                22


<210> 18
<211> 22
<212> RNA
<213> Homo sapiens

<400> 18
aagugcuguc auagcugagg uc                                                22


<210> 19
<211> 22
<212> RNA
<213> Homo sapiens

<400> 19
aaaaugguuc ccuuuagagu gu                                                22


<210> 20
<211> 22
<212> RNA
<213> Homo sapiens

<400> 20
cucuagaggg aagcacuuuc ug                                                22


<210> 21
<211> 22
<212> RNA
<213> Homo sapiens

<400> 21
cucuagaggg aagcacuuuc uc                                                22


<210> 22
<211> 22
<212> RNA
<213> Homo sapiens

<400> 22
caaagcgcuc cccuuuagag gu                                                22


<210> 23
<211> 21
<212> RNA
<213> Homo sapiens

<400> 23
cuccagaggg augcacuuuc u                                                 21


<210> 24
<211> 87
<212> RNA
<213> Homo sapiens

<400> 24
ucucaggcag ugacccucua gauggaagca cugucuguug uauaaaagaa aagaucgugc       60

aucccuuuag aguguuacug uuugaga                                           87


<210> 25
<211> 87
<212> RNA
<213> Homo sapiens

<400> 25
ucucaggcug ucguccucua gagggaagca cuuucuguug ucugaaagaa aagaaagugc       60

uuccuuuuag aggguuaccg uuugaga                                           87


<210> 26
<211> 95
<212> RNA
<213> Homo sapiens

<400> 26
gaagaucuca ggcagugacc cucuagaugg aagcacuguc uguugucuaa gaaaagaucg       60

ugcauccuuu uagaguguua cuguuugaga aaauc                                  95


<210> 27
<211> 90
<212> RNA
<213> Homo sapiens

<400> 27
ucccaugcug ugacccucua gaggaagcac uuucuguuug uugucugaga aaaaacaaag       60

ugcuucccuu uagaguguua ccguuuggga                                        90


<210> 28
<211> 81
<212> RNA
<213> Homo sapiens

<400> 28
caugcuguga cccucuagag ggaagcgcuu ucuguugucu gaaagaaaag aaagugcauc       60

cuuuuagagg uuuacuguuu g                                                 81


<210> 29
<211> 88
<212> RNA
<213> Homo sapiens

<400> 29
ucccaugcug ugacccucca aagggaagcg cuuucuguuu guuuucucuu aaacaaagug       60

ccucccuuua gaguguuacc guuuggga                                          88


<210> 30
<211> 90
<212> RNA
<213> Homo sapiens

<400> 30
ucucaggcug ugaccuucuc gaggaaagaa gcacuuucug uugucugaaa gaaaagaaag       60

ugcuuccuuu cagaggguua cgguuugaga                                        90


<210> 31
<211> 85
<212> RNA
<213> Homo sapiens

<400> 31
cucaggcugu gacacucuag agggaagcgc uuucuguugu cugaaagaaa ggaaagugca       60

uccuuuuaga guguuacugu uugag                                             85


<210> 32
<211> 83
<212> RNA
<213> Homo sapiens

<400> 32
ucaggcugug acccucuuga gggaagcacu uucuguuguc ugaaagaaga gaaagugcuu       60

ccuuuuagag gcuuacuguc uga                                               83


<210> 33
<211> 87
<212> RNA
<213> Homo sapiens

<400> 33
ucucaugcug ugacccuaca aagggaagca cuuucucuug uccaaaggaa aagaaggcgc       60

uucccuuugg aguguuacgg uuugaga                                           87


<210> 34
<211> 83
<212> RNA
<213> Homo sapiens

<400> 34
ucaggcugug acccucuuga gggaagcacu uucuguuguc ugaaagaaga gaaagugcuu       60

ccuuuuagag gcuuacuguc uga                                               83


<210> 35
<211> 84
<212> RNA
<213> Homo sapiens

<400> 35
ucucaugcag ucauucucca aaagggagca cuuucuguuu gaaagaaaac aaagugccuc       60

cuuuuagagu guuacuguuu gaga                                              84


<210> 36
<211> 84
<212> RNA
<213> Homo sapiens

<400> 36
ucucagucug uggcacucag ccuugagggc acuuucuggu gccagaauga aagugcuguc       60

auagcugagg uccaaugacu gagg                                              84


<210> 37
<211> 87
<212> RNA
<213> Homo sapiens

<400> 37
ucucaggcug ugucccucua gagggaagcg cuuucuguug ucugaaagaa aagaaaaugg       60

uucccuuuag aguguuacgc uuugaga                                           87


<210> 38
<211> 85
<212> RNA
<213> Homo sapiens

<400> 38
cucaggcugu gacccucuag agggaagcac uuucuguugc uugaaagaag agaaagcgcu       60

uccuuuuaga ggauuacucu uugag                                             85


<210> 39
<211> 83
<212> RNA
<213> Homo sapiens

<400> 39
ucaugcugug gcccuccaga gggaagcgcu uucuguuguc ugaaagaaaa caaagcgcuc       60

cccuuuagag guuuacgguu uga                                               83


<210> 40
<211> 85
<212> RNA
<213> Homo sapiens

<400> 40
cucaagcugu gacucuccag agggaugcac uuucucuuau gugaaaaaaa agaaggcgcu       60

ucccuuuaga gcguuacggu uuggg                                             85


<210> 41
<211> 67
<212> RNA
<213> Homo sapiens

<400> 41
gugacccucu agauggaagc acugucuguu gucuaagaaa agaucgugca ucccuuuaga       60

guguuac                                                                 67


<210> 42
<211> 88
<212> RNA
<213> Homo sapiens

<400> 42
ucccaugcug ugacccucua gaggaagcac uuucuguuug uugucugaga aaaaacaaag       60

ugcuucccuu uagaguuacu guuuggga                                          88


<210> 43
<211> 61
<212> RNA
<213> Homo sapiens

<400> 43
cccucuacag ggaagcgcuu ucuguugucu gaaagaaaag aaagugcuuc cuuuuagagg       60

g                                                                       61


<210> 44
<211> 87
<212> RNA
<213> Homo sapiens

<400> 44
ucucaggcug ugacccucua aagggaagcg cuuucugugg ucagaaagaa aagcaagugc       60

uuccuuuuag aggguuaccg uuuggga                                           87


<210> 45
<211> 87
<212> RNA
<213> Homo sapiens

<400> 45
ucucaugcug ugacccucua gagggaagca cuuucucuug ucuaaaagaa aagaaagcgc       60

uucucuuuag aggauuacuc uuugaga                                           87


<210> 46
<211> 22
<212> DNA
<213> Homo sapiens

<400> 46
acactctaaa gggatgcacg at                                                22


<210> 47
<211> 22
<212> DNA
<213> Homo sapiens

<400> 47
acactctaaa aggatgcacg at                                                22


<210> 48
<211> 22
<212> DNA
<213> Homo sapiens

<400> 48
aacactctaa agggatgcac ga                                                22


<210> 49
<211> 24
<212> DNA
<213> Homo sapiens

<400> 49
acactctaaa gggaagcact ttgt                                              24


<210> 50
<211> 22
<212> DNA
<213> Homo sapiens

<400> 50
actctaaagg gaagcacttt gt                                                22


<210> 51
<211> 22
<212> DNA
<213> Homo sapiens

<400> 51
aacctctaaa aggatgcact tt                                                22


<210> 52
<211> 22
<212> DNA
<213> Homo sapiens

<400> 52
cactctaaag ggaggcactt tg                                                22


<210> 53
<211> 23
<212> DNA
<213> Homo sapiens

<400> 53
gaaagtgctt ctttcctcga gaa                                               23


<210> 54
<211> 22
<212> DNA
<213> Homo sapiens

<400> 54
acactctaaa aggatgcact tt                                                22


<210> 55
<211> 22
<212> DNA
<213> Homo sapiens

<400> 55
accctctaaa aggaagcact tt                                                22


<210> 56
<211> 21
<212> DNA
<213> Homo sapiens

<400> 56
ccctctaaaa ggaagcactt t                                                 21


<210> 57
<211> 22
<212> DNA
<213> Homo sapiens

<400> 57
aaccctctaa aaggaagcac tt                                                22


<210> 58
<211> 22
<212> DNA
<213> Homo sapiens

<400> 58
gcctctaaaa ggaagcactt tc                                                22


<210> 59
<211> 22
<212> DNA
<213> Homo sapiens

<400> 59
gagaaagtgc ttccctttgt ag                                                22


<210> 60
<211> 18
<212> DNA
<213> Homo sapiens

<400> 60
accctctgaa aggaagca                                                     18


<210> 61
<211> 23
<212> DNA
<213> Homo sapiens

<400> 61
acagaaagtg cttccctcaa gag                                               23


<210> 62
<211> 22
<212> DNA
<213> Homo sapiens

<400> 62
aacactctaa aaggaggcac tt                                                22


<210> 63
<211> 22
<212> DNA
<213> Homo sapiens

<400> 63
gacctcagct atgacagcac tt                                                22


<210> 64
<211> 22
<212> DNA
<213> Homo sapiens

<400> 64
acactctaaa gggaaccatt tt                                                22


<210> 65
<211> 22
<212> DNA
<213> Homo sapiens

<400> 65
cagaaagtgc ttccctctag ag                                                22


<210> 66
<211> 22
<212> DNA
<213> Homo sapiens

<400> 66
gagaaagtgc ttccctctag ag                                                22


<210> 67
<211> 22
<212> DNA
<213> Homo sapiens

<400> 67
acctctaaag gggagcgctt tg                                                22


<210> 68
<211> 21
<212> DNA
<213> Homo sapiens

<400> 68
agaaagtgca tccctctgga g                                                 21


<210> 69
<211> 22
<212> RNA
<213> Homo sapiens

<400> 69
acacucuaaa gggaugcacg au                                                22


<210> 70
<211> 22
<212> RNA
<213> Homo sapiens

<400> 70
acacucuaaa aggaugcacg au                                                22


<210> 71
<211> 22
<212> RNA
<213> Homo sapiens

<400> 71
aacacucuaa agggaugcac ga                                                22


<210> 72
<211> 24
<212> RNA
<213> Homo sapiens

<400> 72
acacucuaaa gggaagcacu uugu                                              24


<210> 73
<211> 22
<212> RNA
<213> Homo sapiens

<400> 73
acucuaaagg gaagcacuuu gu                                                22


<210> 74
<211> 22
<212> RNA
<213> Homo sapiens

<400> 74
aaccucuaaa aggaugcacu uu                                                22


<210> 75
<211> 22
<212> RNA
<213> Homo sapiens

<400> 75
cacucuaaag ggaggcacuu ug                                                22


<210> 76
<211> 23
<212> RNA
<213> Homo sapiens

<400> 76
gaaagugcuu cuuuccucga gaa                                               23


<210> 77
<211> 22
<212> RNA
<213> Homo sapiens

<400> 77
acacucuaaa aggaugcacu uu                                                22


<210> 78
<211> 22
<212> RNA
<213> Homo sapiens

<400> 78
acccucuaaa aggaagcacu uu                                                22


<210> 79
<211> 21
<212> RNA
<213> Homo sapiens

<400> 79
cccucuaaaa ggaagcacuu u                                                 21


<210> 80
<211> 22
<212> RNA
<213> Homo sapiens

<400> 80
aacccucuaa aaggaagcac uu                                                22


<210> 81
<211> 22
<212> RNA
<213> Homo sapiens

<400> 81
gccucuaaaa ggaagcacuu uc                                                22


<210> 82
<211> 22
<212> RNA
<213> Homo sapiens

<400> 82
gagaaagugc uucccuuugu ag                                                22


<210> 83
<211> 18
<212> RNA
<213> Homo sapiens

<400> 83
acccucugaa aggaagca                                                     18


<210> 84
<211> 23
<212> RNA
<213> Homo sapiens

<400> 84
acagaaagug cuucccucaa gag                                               23


<210> 85
<211> 22
<212> RNA
<213> Homo sapiens

<400> 85
aacacucuaa aaggaggcac uu                                                22


<210> 86
<211> 22
<212> RNA
<213> Homo sapiens

<400> 86
gaccucagcu augacagcac uu                                                22


<210> 87
<211> 22
<212> RNA
<213> Homo sapiens

<400> 87
acacucuaaa gggaaccauu uu                                                22


<210> 88
<211> 22
<212> RNA
<213> Homo sapiens

<400> 88
cagaaagugc uucccucuag ag                                                22


<210> 89
<211> 22
<212> RNA
<213> Homo sapiens

<400> 89
gagaaagugc uucccucuag ag                                                22


<210> 90
<211> 22
<212> RNA
<213> Homo sapiens

<400> 90
accucuaaag gggagcgcuu ug                                                22


<210> 91
<211> 21
<212> RNA
<213> Homo sapiens

<400> 91
agaaagugca ucccucugga g                                                 21


<210> 92
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 92
tttttaaagt tttgggatta taggc                                             25


<210> 93
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 93
ataacttaac acgaccgata acgtt                                             25


<210> 94
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 94
tttaaagttt tgggattata ggtgt                                             25


<210> 95
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 95
ataacttaac acaaccaata acatt                                             25


<210> 96
<211> 5163
<212> DNA
<213> Homo sapiens

<300>
<308> NCBI/NM_001042544.1
<309> 2006-07-14
<313> (1)..(5163)

<400> 96
atgccgaggc ctggcaccag cggccgccgc cccctcctgc tggtgctgtt gctgccgctc       60

ttcgcagccg ccacctccgc cgccagcccc agccccagcc ccagccaggt cgtcgaggtc      120

ccgggggtcc ccagccgccc ggccagcgtt gctgtttgtc gctgctgccc gggccagacg      180

tctaggagga gccgctgcat ccgagccttc tgcagggtcc gaagctgcca gcccaaaaag      240

tgtgcaggcc cccagcggtg cctgaaccca gtgcctgcag tgcccagtcc cagccccagc      300

gtgaggaaga gacaggtgtc cctcaactgg cagccactga cgctccagga ggccagagct      360

ctactgaagc ggcggcggcc ccgggggcca gggggccggg gactactgag aaggaggccc      420

ccacagcgtg cccccgctgg caaggccccg gtcctgtgtc ccttgatctg tcacaatggc      480

ggtgtgtgcg tgaagcctga ccgctgcctc tgtcccccgg acttcgctgg caagttctgc      540

cagttgcact cctcgggcgc ccggcccccg gccccggctg taccaggcct cacccgctcc      600

gtgtacacta tgccactggc caaccaccgc gacgacgagc acggcgtggc atctatggtg      660

agcgtccacg tggagcaccc gcaggaggcg tcggtggtgg tgcaccaggt ggagcgtgtg      720

tctggccctt gggaggaggc ggacgctgag gcggtggcgc gggcggaagc ggcggcgcgg      780

gcggaggcgg cagcgcccta cacggtgttg gcacagagcg cgccgcggga ggacggctac      840

tcagatgcct cgggcttcgg ttactgcttt cgggagctgc gcggaggcga atgcgcgtcc      900

ccgctgcccg ggctccggac gcaggaggtc tgctgccgag gggccggctt ggcctggggc      960

gttcacgact gtcagctgtg ctccgagcgc ctggggaact ccgaaagagt gagcgcccca     1020

gatggacctt gtccaaccgg ctttgaaaga gttaatgggt cctgcgaaga tgtggatgag     1080

tgcgcgactg gcgggcgctg ccagcacggc gagtgtgcaa acacgcgcgg cgggtacacg     1140

tgtgtgtgcc ccgacggctt tctgctcgac tcgtcccgca gcagctgcat ctcccaacac     1200

gtgatctcag aggccaaagg gccctgcttc cgcgtgctcc gcgacggcgg ctgttcgctg     1260

cccattctgc ggaacatcac taaacagatc tgctgctgca gccgcgtagg caaggcctgg     1320

ggccggggct gccagctctg cccacccttc ggctcagagg gtttccggga gatctgcccg     1380

gctggtcctg gttaccacta ctcggcctcc gacctccgct acaacaccag acccctgggc     1440

caggagccac cccgagtgtc actcagccag cctcgtaccc tgccagccac ctctcggcca     1500

tctgcaggct ttctgcccac ccatcgcctg gagccccggc ctgaaccccg gcccgatccc     1560

cggcccggcc ctgagcttcc cttgcccagc atccctgcct ggactggtcc tgagattcct     1620

gaatcaggtc cctcctccgg catgtgtcag cgcaaccccc aggtctgcgg cccaggacgc     1680

tgcatttccc ggcccagcgg ctacacctgc gcttgcgact ctggcttccg gctcagcccc     1740

cagggcaccc gatgcattga tgtggacgaa tgtcgccgcg tgcccccgcc ctgtgctccc     1800

gggcgctgcg agaactcacc aggcagcttc cgctgcgtgt gcggcccggg cttccgagcc     1860

ggcccacggg ctgcggaatg cctggatgtg gacgagtgcc accgcgtgcc gccgccgtgt     1920

gacctcgggc gctgcgagaa cacgccaggc agcttcctgt gcgtgtgccc cgccgggtac     1980

caggctgcac cgcacggagc cagctgccag gatgtggatg aatgcaccca gagcccaggc     2040

ctgtgtggcc gaggggcctg caagaacctg cctggctctt tccgctgtgt ttgcccggct     2100

ggcttccggg gctcggcgtg tgaagaggat gtggatgagt gtgcccagga gccgccgccc     2160

tgtgggcccg gccgctgtga caacacggca ggctcctttc actgtgcctg ccctgctggc     2220

ttccgctccc gagggcccgg ggccccctgc caagatgtgg atgagtgtgc ccgaagcccc     2280

ccaccctgca cctacggccg gtgtgagaac acagaaggca gcttccagtg tgtctgcccc     2340

atgggcttcc aacccaacac tgctggctcc gagtgcgagg atgtggatga gtgtgagaac     2400

cacctcgcat gccctgggca ggagtgtgtg aactcgcccg gctccttcca gtgcaggacc     2460

tgtccttctg gccaccacct gcaccgtggc agatgcactg atgtggacga atgcagttcg     2520

ggtgcccctc cctgtggtcc ccacggccac tgcactaaca ccgaaggctc cttccgctgc     2580

agctgcgcgc caggctaccg ggcgccgtcg ggtcggcccg ggccctgcgc agacgtgaac     2640

gagtgcctgg agggcgattt ctgcttccct cacggcgagt gcctcaacac tgacggctcc     2700

tttgcctgta cttgtgcccc tggctaccga cccggacccc gcggagcctc ttgcctcgac     2760

gttgacgagt gcagcgagga ggacctttgc cagagcggca tctgtaccaa caccgacggc     2820

tccttcgagt gcatctgtcc tccgggacac cgcgctggcc cggacctcgc ctcctgcctc     2880

gacgtggacg aatgtcgcga gcgaggccca gccctgtgcg ggtcgcagcg ctgtgagaac     2940

tctcccggct cctaccgctg tgtccgggac tgcgatcctg ggtaccacgc gggccccgag     3000

ggcacctgtg acgatgtgga tgagtgccaa gaatatggtc ccgagatttg tggagcccag     3060

cgttgtgaga acacccctgg ctcctaccgc tgcacaccag cctgtgaccc tggctatcag     3120

cccacgccag ggggcggatg ccaggatgtg gacgaatgcc ggaaccggtc cttctgcggt     3180

gcccacgccg tgtgccagaa cctgcccggc tccttccagt gcctctgtga ccagggttac     3240

gagggggcac gggatgggcg tcactgcgtg gatgtgaacg agtgtgaaac actacagggt     3300

gtatgtggag ctgccctgtg tgaaaatgtc gaaggctcct tcctctgtgt ctgccccaac     3360

agcccggaag agtttgaccc catgactgga cgctgtgttc ccccacgaac ttctgctggc     3420

acgttcccag gctcgcagcc ccaggcacct gctagccccg ttctgcccgc caggccacct     3480

ccgccacccc tgccccgccg acccagcaca cctaggcagg gccctgtggg gagtgggcgc     3540

cgggagtgct actttgacac agcggccccg gatgcatgtg acaacatcct ggctcggaat     3600

gtgacatggc aggagtgctg ctgtactgtg ggtgagggct ggggcagcgg ctgccgcatc     3660

cagcagtgcc cgggcaccga gacagctgag taccagtcat tgtgccctca cggccggggc     3720

tacctggcgc ccagtggaga cctgagcctc cggagagacg tggacgaatg tcagctcttc     3780

cgagaccagg tgtgcaagag tggcgtgtgt gtgaacacgg ccccgggcta ctcatgctat     3840

tgcagcaacg gctactacta ccacacacag cggctggagt gcatcgacaa tgacgagtgc     3900

gccgatgagg aaccggcctg tgagggcggc cgctgtgtca acactgtggg ctcttatcac     3960

tgtacctgcg agcccccact ggtgctggat ggctcgcagc gccgctgcgt ctccaacgag     4020

agccagagcc tcgatgacaa tctgggagtg tgctggcagg aagtgggggc tgacctcgtg     4080

tgcagccacc ctcggctgga ccgtcaggcc acctacacag agtgctgctg cctgtatgga     4140

gaggcctggg gcatggactg cgccctctgc cctgcgcagg actcagatga cttcgaggcc     4200

ctgtgcaatg tgctacgccc ccccgcatat agccccccgc gaccaggtgg ctttggactc     4260

ccctacgagt acggcccaga cttaggtcca ccttaccagg gcctcccata tgggcctgag     4320

ttgtacccac cacctgcgct accctacgac ccctacccac cgccacctgg gcccttcgcc     4380

cgccgggagg ctccttatgg ggcaccccgc ttcgacatgc cagactttga ggacgatggt     4440

ggcccctatg gcgaatctga ggctcctgcg ccacctggcc cgggcacccg ctggccctat     4500

cggtcccggg acacccgccg ctccttccca gagcccgagg agcctcctga aggtggaagc     4560

tatgctggtt ccctggctga gccctacgag gagctggagg cggaggagtg cgggatcctg     4620

gacggctgca ccaacggccg ctgcgtgcgc gtccccgaag gcttcacctg ccgttgcttc     4680

gacggctacc gcctggacat gacccgcatg gcctgcgttg acatcaacga gtgtgatgag     4740

gccgaggctg cctccccgct gtgcgtcaac gcgcgttgcc tcaacacgga tggctccttc     4800

cgctgcatct gccgcccggg attcgcaccc acgcaccagc cgcaccactg tgcgcccgca     4860

cggccccggg cctgagccct ggcacccgct ggccgcccac ccgcgcccgc cactcggggc     4920

ccctgccgcg catcctgcag cccgcttatg cgtatgtgca cggggccgcc cgcctggacc     4980

tggagaaggg acctacggac gcctggaagc tgcgacgccc tgcactgctc ccgcctccac     5040

cagcgcctcc cactgatgtc gtggtcccgg gcctggccca ggggcccctt tacatgccct     5100

ctccctttta taaaattttc cattaaaaac cacctatttt ctatcaaaaa aaaaaaaaaa     5160

aaa                                                                   5163


<210> 97
<211> 1624
<212> PRT
<213> Homo sapiens

<300>
<308> NCBI/NP_001036009.1
<309> 2006-07-14
<313> (1)..(1624)

<400> 97
Met Pro Arg Pro Gly Thr Ser Gly Arg Arg Pro Leu Leu Leu Val Leu 
1               5                   10                  15      


Leu Leu Pro Leu Phe Ala Ala Ala Thr Ser Ala Ala Ser Pro Ser Pro 
            20                  25                  30          


Ser Pro Ser Gln Val Val Glu Val Pro Gly Val Pro Ser Arg Pro Ala 
        35                  40                  45              


Ser Val Ala Val Cys Arg Cys Cys Pro Gly Gln Thr Ser Arg Arg Ser 
    50                  55                  60                  


Arg Cys Ile Arg Ala Phe Cys Arg Val Arg Ser Cys Gln Pro Lys Lys 
65                  70                  75                  80  


Cys Ala Gly Pro Gln Arg Cys Leu Asn Pro Val Pro Ala Val Pro Ser 
                85                  90                  95      


Pro Ser Pro Ser Val Arg Lys Arg Gln Val Ser Leu Asn Trp Gln Pro 
            100                 105                 110         


Leu Thr Leu Gln Glu Ala Arg Ala Leu Leu Lys Arg Arg Arg Pro Arg 
        115                 120                 125             


Gly Pro Gly Gly Arg Gly Leu Leu Arg Arg Arg Pro Pro Gln Arg Ala 
    130                 135                 140                 


Pro Ala Gly Lys Ala Pro Val Leu Cys Pro Leu Ile Cys His Asn Gly 
145                 150                 155                 160 


Gly Val Cys Val Lys Pro Asp Arg Cys Leu Cys Pro Pro Asp Phe Ala 
                165                 170                 175     


Gly Lys Phe Cys Gln Leu His Ser Ser Gly Ala Arg Pro Pro Ala Pro 
            180                 185                 190         


Ala Val Pro Gly Leu Thr Arg Ser Val Tyr Thr Met Pro Leu Ala Asn 
        195                 200                 205             


His Arg Asp Asp Glu His Gly Val Ala Ser Met Val Ser Val His Val 
    210                 215                 220                 


Glu His Pro Gln Glu Ala Ser Val Val Val His Gln Val Glu Arg Val 
225                 230                 235                 240 


Ser Gly Pro Trp Glu Glu Ala Asp Ala Glu Ala Val Ala Arg Ala Glu 
                245                 250                 255     


Ala Ala Ala Arg Ala Glu Ala Ala Ala Pro Tyr Thr Val Leu Ala Gln 
            260                 265                 270         


Ser Ala Pro Arg Glu Asp Gly Tyr Ser Asp Ala Ser Gly Phe Gly Tyr 
        275                 280                 285             


Cys Phe Arg Glu Leu Arg Gly Gly Glu Cys Ala Ser Pro Leu Pro Gly 
    290                 295                 300                 


Leu Arg Thr Gln Glu Val Cys Cys Arg Gly Ala Gly Leu Ala Trp Gly 
305                 310                 315                 320 


Val His Asp Cys Gln Leu Cys Ser Glu Arg Leu Gly Asn Ser Glu Arg 
                325                 330                 335     


Val Ser Ala Pro Asp Gly Pro Cys Pro Thr Gly Phe Glu Arg Val Asn 
            340                 345                 350         


Gly Ser Cys Glu Asp Val Asp Glu Cys Ala Thr Gly Gly Arg Cys Gln 
        355                 360                 365             


His Gly Glu Cys Ala Asn Thr Arg Gly Gly Tyr Thr Cys Val Cys Pro 
    370                 375                 380                 


Asp Gly Phe Leu Leu Asp Ser Ser Arg Ser Ser Cys Ile Ser Gln His 
385                 390                 395                 400 


Val Ile Ser Glu Ala Lys Gly Pro Cys Phe Arg Val Leu Arg Asp Gly 
                405                 410                 415     


Gly Cys Ser Leu Pro Ile Leu Arg Asn Ile Thr Lys Gln Ile Cys Cys 
            420                 425                 430         


Cys Ser Arg Val Gly Lys Ala Trp Gly Arg Gly Cys Gln Leu Cys Pro 
        435                 440                 445             


Pro Phe Gly Ser Glu Gly Phe Arg Glu Ile Cys Pro Ala Gly Pro Gly 
    450                 455                 460                 


Tyr His Tyr Ser Ala Ser Asp Leu Arg Tyr Asn Thr Arg Pro Leu Gly 
465                 470                 475                 480 


Gln Glu Pro Pro Arg Val Ser Leu Ser Gln Pro Arg Thr Leu Pro Ala 
                485                 490                 495     


Thr Ser Arg Pro Ser Ala Gly Phe Leu Pro Thr His Arg Leu Glu Pro 
            500                 505                 510         


Arg Pro Glu Pro Arg Pro Asp Pro Arg Pro Gly Pro Glu Leu Pro Leu 
        515                 520                 525             


Pro Ser Ile Pro Ala Trp Thr Gly Pro Glu Ile Pro Glu Ser Gly Pro 
    530                 535                 540                 


Ser Ser Gly Met Cys Gln Arg Asn Pro Gln Val Cys Gly Pro Gly Arg 
545                 550                 555                 560 


Cys Ile Ser Arg Pro Ser Gly Tyr Thr Cys Ala Cys Asp Ser Gly Phe 
                565                 570                 575     


Arg Leu Ser Pro Gln Gly Thr Arg Cys Ile Asp Val Asp Glu Cys Arg 
            580                 585                 590         


Arg Val Pro Pro Pro Cys Ala Pro Gly Arg Cys Glu Asn Ser Pro Gly 
        595                 600                 605             


Ser Phe Arg Cys Val Cys Gly Pro Gly Phe Arg Ala Gly Pro Arg Ala 
    610                 615                 620                 


Ala Glu Cys Leu Asp Val Asp Glu Cys His Arg Val Pro Pro Pro Cys 
625                 630                 635                 640 


Asp Leu Gly Arg Cys Glu Asn Thr Pro Gly Ser Phe Leu Cys Val Cys 
                645                 650                 655     


Pro Ala Gly Tyr Gln Ala Ala Pro His Gly Ala Ser Cys Gln Asp Val 
            660                 665                 670         


Asp Glu Cys Thr Gln Ser Pro Gly Leu Cys Gly Arg Gly Ala Cys Lys 
        675                 680                 685             


Asn Leu Pro Gly Ser Phe Arg Cys Val Cys Pro Ala Gly Phe Arg Gly 
    690                 695                 700                 


Ser Ala Cys Glu Glu Asp Val Asp Glu Cys Ala Gln Glu Pro Pro Pro 
705                 710                 715                 720 


Cys Gly Pro Gly Arg Cys Asp Asn Thr Ala Gly Ser Phe His Cys Ala 
                725                 730                 735     


Cys Pro Ala Gly Phe Arg Ser Arg Gly Pro Gly Ala Pro Cys Gln Asp 
            740                 745                 750         


Val Asp Glu Cys Ala Arg Ser Pro Pro Pro Cys Thr Tyr Gly Arg Cys 
        755                 760                 765             


Glu Asn Thr Glu Gly Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln 
    770                 775                 780                 


Pro Asn Thr Ala Gly Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn 
785                 790                 795                 800 


His Leu Ala Cys Pro Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe 
                805                 810                 815     


Gln Cys Arg Thr Cys Pro Ser Gly His His Leu His Arg Gly Arg Cys 
            820                 825                 830         


Thr Asp Val Asp Glu Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His 
        835                 840                 845             


Gly His Cys Thr Asn Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro 
    850                 855                 860                 


Gly Tyr Arg Ala Pro Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn 
865                 870                 875                 880 


Glu Cys Leu Glu Gly Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn 
                885                 890                 895     


Thr Asp Gly Ser Phe Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly 
            900                 905                 910         


Pro Arg Gly Ala Ser Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp 
        915                 920                 925             


Leu Cys Gln Ser Gly Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys 
    930                 935                 940                 


Ile Cys Pro Pro Gly His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu 
945                 950                 955                 960 


Asp Val Asp Glu Cys Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln 
                965                 970                 975     


Arg Cys Glu Asn Ser Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp 
            980                 985                 990         


Pro Gly Tyr His Ala Gly Pro Glu  Gly Thr Cys Asp Asp  Val Asp Glu 
        995                 1000                 1005             


Cys Gln  Glu Tyr Gly Pro Glu  Ile Cys Gly Ala Gln  Arg Cys Glu 
    1010                 1015                 1020             


Asn Thr  Pro Gly Ser Tyr Arg  Cys Thr Pro Ala Cys  Asp Pro Gly 
    1025                 1030                 1035             


Tyr Gln  Pro Thr Pro Gly Gly  Gly Cys Gln Asp Val  Asp Glu Cys 
    1040                 1045                 1050             


Arg Asn  Arg Ser Phe Cys Gly  Ala His Ala Val Cys  Gln Asn Leu 
    1055                 1060                 1065             


Pro Gly  Ser Phe Gln Cys Leu  Cys Asp Gln Gly Tyr  Glu Gly Ala 
    1070                 1075                 1080             


Arg Asp  Gly Arg His Cys Val  Asp Val Asn Glu Cys  Glu Thr Leu 
    1085                 1090                 1095             


Gln Gly  Val Cys Gly Ala Ala  Leu Cys Glu Asn Val  Glu Gly Ser 
    1100                 1105                 1110             


Phe Leu  Cys Val Cys Pro Asn  Ser Pro Glu Glu Phe  Asp Pro Met 
    1115                 1120                 1125             


Thr Gly  Arg Cys Val Pro Pro  Arg Thr Ser Ala Gly  Thr Phe Pro 
    1130                 1135                 1140             


Gly Ser  Gln Pro Gln Ala Pro  Ala Ser Pro Val Leu  Pro Ala Arg 
    1145                 1150                 1155             


Pro Pro  Pro Pro Pro Leu Pro  Arg Arg Pro Ser Thr  Pro Arg Gln 
    1160                 1165                 1170             


Gly Pro  Val Gly Ser Gly Arg  Arg Glu Cys Tyr Phe  Asp Thr Ala 
    1175                 1180                 1185             


Ala Pro  Asp Ala Cys Asp Asn  Ile Leu Ala Arg Asn  Val Thr Trp 
    1190                 1195                 1200             


Gln Glu  Cys Cys Cys Thr Val  Gly Glu Gly Trp Gly  Ser Gly Cys 
    1205                 1210                 1215             


Arg Ile  Gln Gln Cys Pro Gly  Thr Glu Thr Ala Glu  Tyr Gln Ser 
    1220                 1225                 1230             


Leu Cys  Pro His Gly Arg Gly  Tyr Leu Ala Pro Ser  Gly Asp Leu 
    1235                 1240                 1245             


Ser Leu  Arg Arg Asp Val Asp  Glu Cys Gln Leu Phe  Arg Asp Gln 
    1250                 1255                 1260             


Val Cys  Lys Ser Gly Val Cys  Val Asn Thr Ala Pro  Gly Tyr Ser 
    1265                 1270                 1275             


Cys Tyr  Cys Ser Asn Gly Tyr  Tyr Tyr His Thr Gln  Arg Leu Glu 
    1280                 1285                 1290             


Cys Ile  Asp Asn Asp Glu Cys  Ala Asp Glu Glu Pro  Ala Cys Glu 
    1295                 1300                 1305             


Gly Gly  Arg Cys Val Asn Thr  Val Gly Ser Tyr His  Cys Thr Cys 
    1310                 1315                 1320             


Glu Pro  Pro Leu Val Leu Asp  Gly Ser Gln Arg Arg  Cys Val Ser 
    1325                 1330                 1335             


Asn Glu  Ser Gln Ser Leu Asp  Asp Asn Leu Gly Val  Cys Trp Gln 
    1340                 1345                 1350             


Glu Val  Gly Ala Asp Leu Val  Cys Ser His Pro Arg  Leu Asp Arg 
    1355                 1360                 1365             


Gln Ala  Thr Tyr Thr Glu Cys  Cys Cys Leu Tyr Gly  Glu Ala Trp 
    1370                 1375                 1380             


Gly Met  Asp Cys Ala Leu Cys  Pro Ala Gln Asp Ser  Asp Asp Phe 
    1385                 1390                 1395             


Glu Ala  Leu Cys Asn Val Leu  Arg Pro Pro Ala Tyr  Ser Pro Pro 
    1400                 1405                 1410             


Arg Pro  Gly Gly Phe Gly Leu  Pro Tyr Glu Tyr Gly  Pro Asp Leu 
    1415                 1420                 1425             


Gly Pro  Pro Tyr Gln Gly Leu  Pro Tyr Gly Pro Glu  Leu Tyr Pro 
    1430                 1435                 1440             


Pro Pro  Ala Leu Pro Tyr Asp  Pro Tyr Pro Pro Pro  Pro Gly Pro 
    1445                 1450                 1455             


Phe Ala  Arg Arg Glu Ala Pro  Tyr Gly Ala Pro Arg  Phe Asp Met 
    1460                 1465                 1470             


Pro Asp  Phe Glu Asp Asp Gly  Gly Pro Tyr Gly Glu  Ser Glu Ala 
    1475                 1480                 1485             


Pro Ala  Pro Pro Gly Pro Gly  Thr Arg Trp Pro Tyr  Arg Ser Arg 
    1490                 1495                 1500             


Asp Thr  Arg Arg Ser Phe Pro  Glu Pro Glu Glu Pro  Pro Glu Gly 
    1505                 1510                 1515             


Gly Ser  Tyr Ala Gly Ser Leu  Ala Glu Pro Tyr Glu  Glu Leu Glu 
    1520                 1525                 1530             


Ala Glu  Glu Cys Gly Ile Leu  Asp Gly Cys Thr Asn  Gly Arg Cys 
    1535                 1540                 1545             


Val Arg  Val Pro Glu Gly Phe  Thr Cys Arg Cys Phe  Asp Gly Tyr 
    1550                 1555                 1560             


Arg Leu  Asp Met Thr Arg Met  Ala Cys Val Asp Ile  Asn Glu Cys 
    1565                 1570                 1575             


Asp Glu  Ala Glu Ala Ala Ser  Pro Leu Cys Val Asn  Ala Arg Cys 
    1580                 1585                 1590             


Leu Asn  Thr Asp Gly Ser Phe  Arg Cys Ile Cys Arg  Pro Gly Phe 
    1595                 1600                 1605             


Ala Pro  Thr His Gln Pro His  His Cys Ala Pro Ala  Arg Pro Arg 
    1610                 1615                 1620             


Ala 
    


<210> 98
<211> 4979
<212> DNA
<213> Homo sapiens

<300>
<308> NCBI/NM_001042545.1
<309> 2006-07-14
<313> (1)..(4979)

<400> 98
agcgcggcgc tgcagccatg gcgggcggcg tgcggctgct ctgggtgtcg ctattggtgc       60

tgctggcgca gctagggccg cagcctggac tgggccggct cggagagcgt ctccgcgtgc      120

gcttcacccc ggtcgtgtgc ggcctgcgct gcgtccatgg gccgaccggc tcccgctgta      180

ccccgacctg cgcgccccgc aacgccacca gcgtggacag cggcgctccc ggcggggcgg      240

ccccgggggg acccggcttc cgcgccttcc tgtgtccctt gatctgtcac aatggcggtg      300

tgtgcgtgaa gcctgaccgc tgcctctgtc ccccggactt cgctggcaag ttctgccagt      360

tgcactcctc gggcgcccgg cccccggccc cggctgtacc aggcctcacc cgctccgtgt      420

acactatgcc actggccaac caccgcgacg acgagcacgg cgtggcatct atggtgagcg      480

tccacgtgga gcacccgcag gaggcgtcgg tggtggtgca ccaggtggag cgtgtgtctg      540

gcccttggga ggaggcggac gctgaggcgg tggcgcgggc ggaagcggcg gcgcgggcgg      600

aggcggcagc gccctacacg gtgttggcac agagcgcgcc gcgggaggac ggctactcag      660

atgcctcggg cttcggttac tgctttcggg agctgcgcgg aggcgaatgc gcgtccccgc      720

tgcccgggct ccggacgcag gaggtctgct gccgaggggc cggcttggcc tggggcgttc      780

acgactgtca gctgtgctcc gagcgcctgg ggaactccga aagagtgagc gccccagatg      840

gaccttgtcc aaccggcttt gaaagagtta atgggtcctg cgaagatgtg gatgagtgcg      900

cgactggcgg gcgctgccag cacggcgagt gtgcaaacac gcgcggcggg tacacgtgtg      960

tgtgccccga cggctttctg ctcgactcgt cccgcagcag ctgcatctcc caacacgtga     1020

tctcagaggc caaagggccc tgcttccgcg tgctccgcga cggcggctgt tcgctgccca     1080

ttctgcggaa catcactaaa cagatctgct gctgcagccg cgtaggcaag gcctggggcc     1140

ggggctgcca gctctgccca cccttcggct cagagggttt ccgggagatc tgcccggctg     1200

gtcctggtta ccactactcg gcctccgacc tccgctacaa caccagaccc ctgggccagg     1260

agccaccccg agtgtcactc agccagcctc gtaccctgcc agccacctct cggccatctg     1320

caggctttct gcccacccat cgcctggagc cccggcctga accccggccc gatccccggc     1380

ccggccctga gcttcccttg cccagcatcc ctgcctggac tggtcctgag attcctgaat     1440

caggtccctc ctccggcatg tgtcagcgca acccccaggt ctgcggccca ggacgctgca     1500

tttcccggcc cagcggctac acctgcgctt gcgactctgg cttccggctc agcccccagg     1560

gcacccgatg cattgatgtg gacgaatgtc gccgcgtgcc cccgccctgt gctcccgggc     1620

gctgcgagaa ctcaccaggc agcttccgct gcgtgtgcgg cccgggcttc cgagccggcc     1680

cacgggctgc ggaatgcctg gatgtggacg agtgccaccg cgtgccgccg ccgtgtgacc     1740

tcgggcgctg cgagaacacg ccaggcagct tcctgtgcgt gtgccccgcc gggtaccagg     1800

ctgcaccgca cggagccagc tgccaggatg tggatgaatg cacccagagc ccaggcctgt     1860

gtggccgagg ggcctgcaag aacctgcctg gctctttccg ctgtgtttgc ccggctggct     1920

tccggggctc ggcgtgtgaa gaggatgtgg atgagtgtgc ccaggagccg ccgccctgtg     1980

ggcccggccg ctgtgacaac acggcaggct cctttcactg tgcctgccct gctggcttcc     2040

gctcccgagg gcccggggcc ccctgccaag atgtggatga gtgtgcccga agccccccac     2100

cctgcaccta cggccggtgt gagaacacag aaggcagctt ccagtgtgtc tgccccatgg     2160

gcttccaacc caacactgct ggctccgagt gcgaggatgt ggatgagtgt gagaaccacc     2220

tcgcatgccc tgggcaggag tgtgtgaact cgcccggctc cttccagtgc aggacctgtc     2280

cttctggcca ccacctgcac cgtggcagat gcactgatgt ggacgaatgc agttcgggtg     2340

cccctccctg tggtccccac ggccactgca ctaacaccga aggctccttc cgctgcagct     2400

gcgcgccagg ctaccgggcg ccgtcgggtc ggcccgggcc ctgcgcagac gtgaacgagt     2460

gcctggaggg cgatttctgc ttccctcacg gcgagtgcct caacactgac ggctcctttg     2520

cctgtacttg tgcccctggc taccgacccg gaccccgcgg agcctcttgc ctcgacgttg     2580

acgagtgcag cgaggaggac ctttgccaga gcggcatctg taccaacacc gacggctcct     2640

tcgagtgcat ctgtcctccg ggacaccgcg ctggcccgga cctcgcctcc tgcctcgacg     2700

tggacgaatg tcgcgagcga ggcccagccc tgtgcgggtc gcagcgctgt gagaactctc     2760

ccggctccta ccgctgtgtc cgggactgcg atcctgggta ccacgcgggc cccgagggca     2820

cctgtgacga tgtggatgag tgccaagaat atggtcccga gatttgtgga gcccagcgtt     2880

gtgagaacac ccctggctcc taccgctgca caccagcctg tgaccctggc tatcagccca     2940

cgccaggggg cggatgccag gatgtggacg aatgccggaa ccggtccttc tgcggtgccc     3000

acgccgtgtg ccagaacctg cccggctcct tccagtgcct ctgtgaccag ggttacgagg     3060

gggcacggga tgggcgtcac tgcgtggatg tgaacgagtg tgaaacacta cagggtgtat     3120

gtggagctgc cctgtgtgaa aatgtcgaag gctccttcct ctgtgtctgc cccaacagcc     3180

cggaagagtt tgaccccatg actggacgct gtgttccccc acgaacttct gctggcacgt     3240

tcccaggctc gcagccccag gcacctgcta gccccgttct gcccgccagg ccacctccgc     3300

cacccctgcc ccgccgaccc agcacaccta ggcagggccc tgtggggagt gggcgccggg     3360

agtgctactt tgacacagcg gccccggatg catgtgacaa catcctggct cggaatgtga     3420

catggcagga gtgctgctgt actgtgggtg agggctgggg cagcggctgc cgcatccagc     3480

agtgcccggg caccgagaca gctgagtacc agtcattgtg ccctcacggc cggggctacc     3540

tggcgcccag tggagacctg agcctccgga gagacgtgga cgaatgtcag ctcttccgag     3600

accaggtgtg caagagtggc gtgtgtgtga acacggcccc gggctactca tgctattgca     3660

gcaacggcta ctactaccac acacagcggc tggagtgcat cgacaatgac gagtgcgccg     3720

atgaggaacc ggcctgtgag ggcggccgct gtgtcaacac tgtgggctct tatcactgta     3780

cctgcgagcc cccactggtg ctggatggct cgcagcgccg ctgcgtctcc aacgagagcc     3840

agagcctcga tgacaatctg ggagtgtgct ggcaggaagt gggggctgac ctcgtgtgca     3900

gccaccctcg gctggaccgt caggccacct acacagagtg ctgctgcctg tatggagagg     3960

cctggggcat ggactgcgcc ctctgccctg cgcaggactc agatgacttc gaggccctgt     4020

gcaatgtgct acgccccccc gcatatagcc ccccgcgacc aggtggcttt ggactcccct     4080

acgagtacgg cccagactta ggtccacctt accagggcct cccatatggg cctgagttgt     4140

acccaccacc tgcgctaccc tacgacccct acccaccgcc acctgggccc ttcgcccgcc     4200

gggaggctcc ttatggggca ccccgcttcg acatgccaga ctttgaggac gatggtggcc     4260

cctatggcga atctgaggct cctgcgccac ctggcccggg cacccgctgg ccctatcggt     4320

cccgggacac ccgccgctcc ttcccagagc ccgaggagcc tcctgaaggt ggaagctatg     4380

ctggttccct ggctgagccc tacgaggagc tggaggcgga ggagtgcggg atcctggacg     4440

gctgcaccaa cggccgctgc gtgcgcgtcc ccgaaggctt cacctgccgt tgcttcgacg     4500

gctaccgcct ggacatgacc cgcatggcct gcgttgacat caacgagtgt gatgaggccg     4560

aggctgcctc cccgctgtgc gtcaacgcgc gttgcctcaa cacggatggc tccttccgct     4620

gcatctgccg cccgggattc gcacccacgc accagccgca ccactgtgcg cccgcacggc     4680

cccgggcctg agccctggca cccgctggcc gcccacccgc gcccgccact cggggcccct     4740

gccgcgcatc ctgcagcccg cttatgcgta tgtgcacggg gccgcccgcc tggacctgga     4800

gaagggacct acggacgcct ggaagctgcg acgccctgca ctgctcccgc ctccaccagc     4860

gcctcccact gatgtcgtgg tcccgggcct ggcccagggg cccctttaca tgccctctcc     4920

cttttataaa attttccatt aaaaaccacc tattttctat caaaaaaaaa aaaaaaaaa      4979


<210> 99
<211> 1557
<212> PRT
<213> Homo sapiens

<300>
<308> NCBI/NP_001036010.1
<309> 2006-07-14
<313> (1)..(1557)

<400> 99
Met Ala Gly Gly Val Arg Leu Leu Trp Val Ser Leu Leu Val Leu Leu 
1               5                   10                  15      


Ala Gln Leu Gly Pro Gln Pro Gly Leu Gly Arg Leu Gly Glu Arg Leu 
            20                  25                  30          


Arg Val Arg Phe Thr Pro Val Val Cys Gly Leu Arg Cys Val His Gly 
        35                  40                  45              


Pro Thr Gly Ser Arg Cys Thr Pro Thr Cys Ala Pro Arg Asn Ala Thr 
    50                  55                  60                  


Ser Val Asp Ser Gly Ala Pro Gly Gly Ala Ala Pro Gly Gly Pro Gly 
65                  70                  75                  80  


Phe Arg Ala Phe Leu Cys Pro Leu Ile Cys His Asn Gly Gly Val Cys 
                85                  90                  95      


Val Lys Pro Asp Arg Cys Leu Cys Pro Pro Asp Phe Ala Gly Lys Phe 
            100                 105                 110         


Cys Gln Leu His Ser Ser Gly Ala Arg Pro Pro Ala Pro Ala Val Pro 
        115                 120                 125             


Gly Leu Thr Arg Ser Val Tyr Thr Met Pro Leu Ala Asn His Arg Asp 
    130                 135                 140                 


Asp Glu His Gly Val Ala Ser Met Val Ser Val His Val Glu His Pro 
145                 150                 155                 160 


Gln Glu Ala Ser Val Val Val His Gln Val Glu Arg Val Ser Gly Pro 
                165                 170                 175     


Trp Glu Glu Ala Asp Ala Glu Ala Val Ala Arg Ala Glu Ala Ala Ala 
            180                 185                 190         


Arg Ala Glu Ala Ala Ala Pro Tyr Thr Val Leu Ala Gln Ser Ala Pro 
        195                 200                 205             


Arg Glu Asp Gly Tyr Ser Asp Ala Ser Gly Phe Gly Tyr Cys Phe Arg 
    210                 215                 220                 


Glu Leu Arg Gly Gly Glu Cys Ala Ser Pro Leu Pro Gly Leu Arg Thr 
225                 230                 235                 240 


Gln Glu Val Cys Cys Arg Gly Ala Gly Leu Ala Trp Gly Val His Asp 
                245                 250                 255     


Cys Gln Leu Cys Ser Glu Arg Leu Gly Asn Ser Glu Arg Val Ser Ala 
            260                 265                 270         


Pro Asp Gly Pro Cys Pro Thr Gly Phe Glu Arg Val Asn Gly Ser Cys 
        275                 280                 285             


Glu Asp Val Asp Glu Cys Ala Thr Gly Gly Arg Cys Gln His Gly Glu 
    290                 295                 300                 


Cys Ala Asn Thr Arg Gly Gly Tyr Thr Cys Val Cys Pro Asp Gly Phe 
305                 310                 315                 320 


Leu Leu Asp Ser Ser Arg Ser Ser Cys Ile Ser Gln His Val Ile Ser 
                325                 330                 335     


Glu Ala Lys Gly Pro Cys Phe Arg Val Leu Arg Asp Gly Gly Cys Ser 
            340                 345                 350         


Leu Pro Ile Leu Arg Asn Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg 
        355                 360                 365             


Val Gly Lys Ala Trp Gly Arg Gly Cys Gln Leu Cys Pro Pro Phe Gly 
    370                 375                 380                 


Ser Glu Gly Phe Arg Glu Ile Cys Pro Ala Gly Pro Gly Tyr His Tyr 
385                 390                 395                 400 


Ser Ala Ser Asp Leu Arg Tyr Asn Thr Arg Pro Leu Gly Gln Glu Pro 
                405                 410                 415     


Pro Arg Val Ser Leu Ser Gln Pro Arg Thr Leu Pro Ala Thr Ser Arg 
            420                 425                 430         


Pro Ser Ala Gly Phe Leu Pro Thr His Arg Leu Glu Pro Arg Pro Glu 
        435                 440                 445             


Pro Arg Pro Asp Pro Arg Pro Gly Pro Glu Leu Pro Leu Pro Ser Ile 
    450                 455                 460                 


Pro Ala Trp Thr Gly Pro Glu Ile Pro Glu Ser Gly Pro Ser Ser Gly 
465                 470                 475                 480 


Met Cys Gln Arg Asn Pro Gln Val Cys Gly Pro Gly Arg Cys Ile Ser 
                485                 490                 495     


Arg Pro Ser Gly Tyr Thr Cys Ala Cys Asp Ser Gly Phe Arg Leu Ser 
            500                 505                 510         


Pro Gln Gly Thr Arg Cys Ile Asp Val Asp Glu Cys Arg Arg Val Pro 
        515                 520                 525             


Pro Pro Cys Ala Pro Gly Arg Cys Glu Asn Ser Pro Gly Ser Phe Arg 
    530                 535                 540                 


Cys Val Cys Gly Pro Gly Phe Arg Ala Gly Pro Arg Ala Ala Glu Cys 
545                 550                 555                 560 


Leu Asp Val Asp Glu Cys His Arg Val Pro Pro Pro Cys Asp Leu Gly 
                565                 570                 575     


Arg Cys Glu Asn Thr Pro Gly Ser Phe Leu Cys Val Cys Pro Ala Gly 
            580                 585                 590         


Tyr Gln Ala Ala Pro His Gly Ala Ser Cys Gln Asp Val Asp Glu Cys 
        595                 600                 605             


Thr Gln Ser Pro Gly Leu Cys Gly Arg Gly Ala Cys Lys Asn Leu Pro 
    610                 615                 620                 


Gly Ser Phe Arg Cys Val Cys Pro Ala Gly Phe Arg Gly Ser Ala Cys 
625                 630                 635                 640 


Glu Glu Asp Val Asp Glu Cys Ala Gln Glu Pro Pro Pro Cys Gly Pro 
                645                 650                 655     


Gly Arg Cys Asp Asn Thr Ala Gly Ser Phe His Cys Ala Cys Pro Ala 
            660                 665                 670         


Gly Phe Arg Ser Arg Gly Pro Gly Ala Pro Cys Gln Asp Val Asp Glu 
        675                 680                 685             


Cys Ala Arg Ser Pro Pro Pro Cys Thr Tyr Gly Arg Cys Glu Asn Thr 
    690                 695                 700                 


Glu Gly Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln Pro Asn Thr 
705                 710                 715                 720 


Ala Gly Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn His Leu Ala 
                725                 730                 735     


Cys Pro Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe Gln Cys Arg 
            740                 745                 750         


Thr Cys Pro Ser Gly His His Leu His Arg Gly Arg Cys Thr Asp Val 
        755                 760                 765             


Asp Glu Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His Gly His Cys 
    770                 775                 780                 


Thr Asn Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro Gly Tyr Arg 
785                 790                 795                 800 


Ala Pro Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn Glu Cys Leu 
                805                 810                 815     


Glu Gly Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn Thr Asp Gly 
            820                 825                 830         


Ser Phe Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly Pro Arg Gly 
        835                 840                 845             


Ala Ser Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln 
    850                 855                 860                 


Ser Gly Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro 
865                 870                 875                 880 


Pro Gly His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp 
                885                 890                 895     


Glu Cys Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu 
            900                 905                 910         


Asn Ser Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr 
        915                 920                 925             


His Ala Gly Pro Glu Gly Thr Cys Asp Asp Val Asp Glu Cys Gln Glu 
    930                 935                 940                 


Tyr Gly Pro Glu Ile Cys Gly Ala Gln Arg Cys Glu Asn Thr Pro Gly 
945                 950                 955                 960 


Ser Tyr Arg Cys Thr Pro Ala Cys Asp Pro Gly Tyr Gln Pro Thr Pro 
                965                 970                 975     


Gly Gly Gly Cys Gln Asp Val Asp Glu Cys Arg Asn Arg Ser Phe Cys 
            980                 985                 990         


Gly Ala His Ala Val Cys Gln Asn  Leu Pro Gly Ser Phe  Gln Cys Leu 
        995                 1000                 1005             


Cys Asp  Gln Gly Tyr Glu Gly  Ala Arg Asp Gly Arg  His Cys Val 
    1010                 1015                 1020             


Asp Val  Asn Glu Cys Glu Thr  Leu Gln Gly Val Cys  Gly Ala Ala 
    1025                 1030                 1035             


Leu Cys  Glu Asn Val Glu Gly  Ser Phe Leu Cys Val  Cys Pro Asn 
    1040                 1045                 1050             


Ser Pro  Glu Glu Phe Asp Pro  Met Thr Gly Arg Cys  Val Pro Pro 
    1055                 1060                 1065             


Arg Thr  Ser Ala Gly Thr Phe  Pro Gly Ser Gln Pro  Gln Ala Pro 
    1070                 1075                 1080             


Ala Ser  Pro Val Leu Pro Ala  Arg Pro Pro Pro Pro  Pro Leu Pro 
    1085                 1090                 1095             


Arg Arg  Pro Ser Thr Pro Arg  Gln Gly Pro Val Gly  Ser Gly Arg 
    1100                 1105                 1110             


Arg Glu  Cys Tyr Phe Asp Thr  Ala Ala Pro Asp Ala  Cys Asp Asn 
    1115                 1120                 1125             


Ile Leu  Ala Arg Asn Val Thr  Trp Gln Glu Cys Cys  Cys Thr Val 
    1130                 1135                 1140             


Gly Glu  Gly Trp Gly Ser Gly  Cys Arg Ile Gln Gln  Cys Pro Gly 
    1145                 1150                 1155             


Thr Glu  Thr Ala Glu Tyr Gln  Ser Leu Cys Pro His  Gly Arg Gly 
    1160                 1165                 1170             


Tyr Leu  Ala Pro Ser Gly Asp  Leu Ser Leu Arg Arg  Asp Val Asp 
    1175                 1180                 1185             


Glu Cys  Gln Leu Phe Arg Asp  Gln Val Cys Lys Ser  Gly Val Cys 
    1190                 1195                 1200             


Val Asn  Thr Ala Pro Gly Tyr  Ser Cys Tyr Cys Ser  Asn Gly Tyr 
    1205                 1210                 1215             


Tyr Tyr  His Thr Gln Arg Leu  Glu Cys Ile Asp Asn  Asp Glu Cys 
    1220                 1225                 1230             


Ala Asp  Glu Glu Pro Ala Cys  Glu Gly Gly Arg Cys  Val Asn Thr 
    1235                 1240                 1245             


Val Gly  Ser Tyr His Cys Thr  Cys Glu Pro Pro Leu  Val Leu Asp 
    1250                 1255                 1260             


Gly Ser  Gln Arg Arg Cys Val  Ser Asn Glu Ser Gln  Ser Leu Asp 
    1265                 1270                 1275             


Asp Asn  Leu Gly Val Cys Trp  Gln Glu Val Gly Ala  Asp Leu Val 
    1280                 1285                 1290             


Cys Ser  His Pro Arg Leu Asp  Arg Gln Ala Thr Tyr  Thr Glu Cys 
    1295                 1300                 1305             


Cys Cys  Leu Tyr Gly Glu Ala  Trp Gly Met Asp Cys  Ala Leu Cys 
    1310                 1315                 1320             


Pro Ala  Gln Asp Ser Asp Asp  Phe Glu Ala Leu Cys  Asn Val Leu 
    1325                 1330                 1335             


Arg Pro  Pro Ala Tyr Ser Pro  Pro Arg Pro Gly Gly  Phe Gly Leu 
    1340                 1345                 1350             


Pro Tyr  Glu Tyr Gly Pro Asp  Leu Gly Pro Pro Tyr  Gln Gly Leu 
    1355                 1360                 1365             


Pro Tyr  Gly Pro Glu Leu Tyr  Pro Pro Pro Ala Leu  Pro Tyr Asp 
    1370                 1375                 1380             


Pro Tyr  Pro Pro Pro Pro Gly  Pro Phe Ala Arg Arg  Glu Ala Pro 
    1385                 1390                 1395             


Tyr Gly  Ala Pro Arg Phe Asp  Met Pro Asp Phe Glu  Asp Asp Gly 
    1400                 1405                 1410             


Gly Pro  Tyr Gly Glu Ser Glu  Ala Pro Ala Pro Pro  Gly Pro Gly 
    1415                 1420                 1425             


Thr Arg  Trp Pro Tyr Arg Ser  Arg Asp Thr Arg Arg  Ser Phe Pro 
    1430                 1435                 1440             


Glu Pro  Glu Glu Pro Pro Glu  Gly Gly Ser Tyr Ala  Gly Ser Leu 
    1445                 1450                 1455             


Ala Glu  Pro Tyr Glu Glu Leu  Glu Ala Glu Glu Cys  Gly Ile Leu 
    1460                 1465                 1470             


Asp Gly  Cys Thr Asn Gly Arg  Cys Val Arg Val Pro  Glu Gly Phe 
    1475                 1480                 1485             


Thr Cys  Arg Cys Phe Asp Gly  Tyr Arg Leu Asp Met  Thr Arg Met 
    1490                 1495                 1500             


Ala Cys  Val Asp Ile Asn Glu  Cys Asp Glu Ala Glu  Ala Ala Ser 
    1505                 1510                 1515             


Pro Leu  Cys Val Asn Ala Arg  Cys Leu Asn Thr Asp  Gly Ser Phe 
    1520                 1525                 1530             


Arg Cys  Ile Cys Arg Pro Gly  Phe Ala Pro Thr His  Gln Pro His 
    1535                 1540                 1545             


His Cys  Ala Pro Ala Arg Pro  Arg Ala 
    1550                 1555         


<210> 100
<211> 5052
<212> DNA
<213> Homo sapiens

<300>
<308> NCBI/NM_003573.2
<309> 1999-03-24
<313> (1)..(5052)

<400> 100
atgggagacg taaaagcgtt gctgtttgtc gctgctgccc gggccagacg tctaggagga       60

gccgctgcat ccgagtccct ggctgtctcc gaagccttct gcagggtccg aagctgccag      120

cccaaaaagt gtgcaggccc ccagcggtgc ctgaacccag tgcctgcagt gcccagtccc      180

agccccagcg tgaggaagag acaggtgtcc ctcaactggc agccactgac gctccaggag      240

gccagagctc tactgaagcg gcggcggccc cgggggccag ggggccgggg actactgaga      300

aggaggcccc cacagcgtgc ccccgctggc aaggccccgg tcctgtgtcc cttgatctgt      360

cacaatggcg gtgtgtgcgt gaagcctgac cgctgcctct gtcccccgga cttcgctggc      420

aagttctgcc agttgcactc ctcgggcgcc cggcccccgg ccccggctgt accaggcctc      480

acccgctccg tgtacactat gccactggcc aaccaccgcg acgacgagca cggcgtggca      540

tctatggtga gcgtccacgt ggagcacccg caggaggcgt cggtggtggt gcaccaggtg      600

gagcgtgtgt ctggcccttg ggaggaggcg gacgctgagg cggtggcgcg ggcggaagcg      660

gcggcgcggg cggaggcggc agcgccctac acggtgttgg cacagagcgc gccgcgggag      720

gacggctact cagatgcctc gggcttcggt tactgctttc gggagctgcg cggaggcgaa      780

tgcgcgtccc cgctgcccgg gctccggacg caggaggtct gctgccgagg ggccggcttg      840

gcctggggcg ttcacgactg tcagctgtgc tccgagcgcc tggggaactc cgaaagagtg      900

agcgccccag atggaccttg tccaaccggc tttgaaagag ttaatgggtc ctgcgaagat      960

gtggatgagt gcgcgactgg cgggcgctgc cagcacggcg agtgtgcaaa cacgcgcggc     1020

gggtacacgt gtgtgtgccc cgacggcttt ctgctcgact cgtcccgcag cagctgcatc     1080

tcccaacacg tgatctcaga ggccaaaggg ccctgcttcc gcgtgctccg cgacggcggc     1140

tgttcgctgc ccattctgcg gaacatcact aaacagatct gctgctgcag ccgcgtaggc     1200

aaggcctggg gccggggctg ccagctctgc ccacccttcg gctcagaggg tttccgggag     1260

atctgcccgg ctggtcctgg ttaccactac tcggcctccg acctccgcta caacaccaga     1320

cccctgggcc aggagccacc ccgagtgtca ctcagccagc ctcgtaccct gccagccacc     1380

tctcggccat ctgcaggctt tctgcccacc catcgcctgg agccccggcc tgaaccccgg     1440

cccgatcccc ggcccggccc tgagcttccc ttgcccagca tccctgcctg gactggtcct     1500

gagattcctg aatcaggtcc ctcctccggc atgtgtcagc gcaaccccca ggtctgcggc     1560

ccaggacgct gcatttcccg gcccagcggc tacacctgcg cttgcgactc tggcttccgg     1620

ctcagccccc agggcacccg atgcattgat gtggacgaat gtcgccgcgt gcccccgccc     1680

tgtgctcccg ggcgctgcga gaactcacca ggcagcttcc gctgcgtgtg cggcccgggc     1740

ttccgagccg gcccacgggc tgcggaatgc ctggatgtgg acgagtgcca ccgcgtgccg     1800

ccgccgtgtg acctcgggcg ctgcgagaac acgccaggca gcttcctgtg cgtgtgcccc     1860

gccgggtacc aggctgcacc gcacggagcc agctgccagg atgtggatga atgcacccag     1920

agcccaggcc tgtgtggccg aggggcctgc aagaacctgc ctggctcttt ccgctgtgtt     1980

tgcccggctg gcttccgggg ctcggcgtgt gaagaggatg tggatgagtg tgcccaggag     2040

ccgccgccct gtgggcccgg ccgctgtgac aacacggcag gctcctttca ctgtgcctgc     2100

cctgctggct tccgctcccg agggcccggg gccccctgcc aagatgtgga tgagtgtgcc     2160

cgaagccccc caccctgcac ctacggccgg tgtgagaaca cagaaggcag cttccagtgt     2220

gtctgcccca tgggcttcca acccaacact gctggctccg agtgcgagga tgtggatgag     2280

tgtgagaacc acctcgcatg ccctgggcag gagtgtgtga actcgcccgg ctccttccag     2340

tgcaggacct gtccttctgg ccaccacctg caccgtggca gatgcactga tgtggacgaa     2400

tgcagttcgg gtgcccctcc ctgtggtccc cacggccact gcactaacac cgaaggctcc     2460

ttccgctgca gctgcgcgcc aggctaccgg gcgccgtcgg gtcggcccgg gccctgcgca     2520

gacgtgaacg agtgcctgga gggcgatttc tgcttccctc acggcgagtg cctcaacact     2580

gacggctcct ttgcctgtac ttgtgcccct ggctaccgac ccggaccccg cggagcctct     2640

tgcctcgacg ttgacgagtg cagcgaggag gacctttgcc agagcggcat ctgtaccaac     2700

accgacggct ccttcgagtg catctgtcct ccgggacacc gcgctggccc ggacctcgcc     2760

tcctgcctcg acgtggacga atgtcgcgag cgaggcccag ccctgtgcgg gtcgcagcgc     2820

tgtgagaact ctcccggctc ctaccgctgt gtccgggact gcgatcctgg gtaccacgcg     2880

ggccccgagg gcacctgtga cgatgtggat gagtgccaag aatatggtcc cgagatttgt     2940

ggagcccagc gttgtgagaa cacccctggc tcctaccgct gcacaccagc ctgtgaccct     3000

ggctatcagc ccacgccagg gggcggatgc caggatgtgg acgaatgccg gaaccggtcc     3060

ttctgcggtg cccacgccgt gtgccagaac ctgcccggct ccttccagtg cctctgtgac     3120

cagggttacg agggggcacg ggatgggcgt cactgcgtgg atgtgaacga gtgtgaaaca     3180

ctacagggtg tatgtggagc tgccctgtgt gaaaatgtcg aaggctcctt cctctgtgtc     3240

tgccccaaca gcccggaaga gtttgacccc atgactggac gctgtgttcc cccacgaact     3300

tctgctggca cgttcccagg ctcgcagccc caggcacctg ctagccccgt tctgcccgcc     3360

aggccacctc cgccacccct gccccgccga cccagcacac ctaggcaggg ccctgtgggg     3420

agtgggcgcc gggagtgcta ctttgacaca gcggccccgg atgcatgtga caacatcctg     3480

gctcggaatg tgacatggca ggagtgctgc tgtactgtgg gtgagggctg gggcagcggc     3540

tgccgcatcc agcagtgccc gggcaccgag acagctgagt accagtcatt gtgccctcac     3600

ggccggggct acctggcgcc cagtggagac ctgagcctcc ggagagacgt ggacgaatgt     3660

cagctcttcc gagaccaggt gtgcaagagt ggcgtgtgtg tgaacacggc cccgggctac     3720

tcatgctatt gcagcaacgg ctactactac cacacacagc ggctggagtg catcgacaat     3780

gacgagtgcg ccgatgagga accggcctgt gagggcggcc gctgtgtcaa cactgtgggc     3840

tcttatcact gtacctgcga gcccccactg gtgctggatg gctcgcagcg ccgctgcgtc     3900

tccaacgaga gccagagcct cgatgacaat ctgggagtgt gctggcagga agtgggggct     3960

gacctcgtgt gcagccaccc tcggctggac cgtcaggcca cctacacaga gtgctgctgc     4020

ctgtatggag aggcctgggg catggactgc gccctctgcc ctgcgcagga ctcagatgac     4080

ttcgaggccc tgtgcaatgt gctacgcccc cccgcatata gccccccgcg accaggtggc     4140

tttggactcc cctacgagta cggcccagac ttaggtccac cttaccaggg cctcccatat     4200

gggcctgagt tgtacccacc acctgcgcta ccctacgacc cctacccacc gccacctggg     4260

cccttcgccc gccgggaggc tccttatggg gcaccccgct tcgacatgcc agactttgag     4320

gacgatggtg gcccctatgg cgaatctgag gctcctgcgc cacctggccc gggcacccgc     4380

tggccctatc ggtcccggga cacccgccgc tccttcccag agcccgagga gcctcctgaa     4440

ggtggaagct atgctggttc cctggctgag ccctacgagg agctggaggc ggaggagtgc     4500

gggatcctgg acggctgcac caacggccgc tgcgtgcgcg tccccgaagg cttcacctgc     4560

cgttgcttcg acggctaccg cctggacatg acccgcatgg cctgcgttga catcaacgag     4620

tgtgatgagg ccgaggctgc ctccccgctg tgcgtcaacg cgcgttgcct caacacggat     4680

ggctccttcc gctgcatctg ccgcccggga ttcgcaccca cgcaccagcc gcaccactgt     4740

gcgcccgcac ggccccgggc ctgagccctg gcacccgctg gccgcccacc cgcgcccgcc     4800

actcggggcc cctgccgcgc atcctgcagc ccgcttatgc gtatgtgcac ggggccgccc     4860

gcctggacct ggagaaggga cctacggacg cctggaagct gcgacgccct gcactgctcc     4920

cgcctccacc agcgcctccc actgatgtcg tggtcccggg cctggcccag gggccccttt     4980

acatgccctc tcccttttat aaaattttcc attaaaaacc acctattttc tatcaaaaaa     5040

aaaaaaaaaa aa                                                         5052


<210> 101
<211> 1587
<212> PRT
<213> Homo sapiens

<300>
<308> NCBI/NP_003564.2
<309> 1999-03-24
<313> (1)..(1587)

<400> 101
Met Gly Asp Val Lys Ala Leu Leu Phe Val Ala Ala Ala Arg Ala Arg 
1               5                   10                  15      


Arg Leu Gly Gly Ala Ala Ala Ser Glu Ser Leu Ala Val Ser Glu Ala 
            20                  25                  30          


Phe Cys Arg Val Arg Ser Cys Gln Pro Lys Lys Cys Ala Gly Pro Gln 
        35                  40                  45              


Arg Cys Leu Asn Pro Val Pro Ala Val Pro Ser Pro Ser Pro Ser Val 
    50                  55                  60                  


Arg Lys Arg Gln Val Ser Leu Asn Trp Gln Pro Leu Thr Leu Gln Glu 
65                  70                  75                  80  


Ala Arg Ala Leu Leu Lys Arg Arg Arg Pro Arg Gly Pro Gly Gly Arg 
                85                  90                  95      


Gly Leu Leu Arg Arg Arg Pro Pro Gln Arg Ala Pro Ala Gly Lys Ala 
            100                 105                 110         


Pro Val Leu Cys Pro Leu Ile Cys His Asn Gly Gly Val Cys Val Lys 
        115                 120                 125             


Pro Asp Arg Cys Leu Cys Pro Pro Asp Phe Ala Gly Lys Phe Cys Gln 
    130                 135                 140                 


Leu His Ser Ser Gly Ala Arg Pro Pro Ala Pro Ala Val Pro Gly Leu 
145                 150                 155                 160 


Thr Arg Ser Val Tyr Thr Met Pro Leu Ala Asn His Arg Asp Asp Glu 
                165                 170                 175     


His Gly Val Ala Ser Met Val Ser Val His Val Glu His Pro Gln Glu 
            180                 185                 190         


Ala Ser Val Val Val His Gln Val Glu Arg Val Ser Gly Pro Trp Glu 
        195                 200                 205             


Glu Ala Asp Ala Glu Ala Val Ala Arg Ala Glu Ala Ala Ala Arg Ala 
    210                 215                 220                 


Glu Ala Ala Ala Pro Tyr Thr Val Leu Ala Gln Ser Ala Pro Arg Glu 
225                 230                 235                 240 


Asp Gly Tyr Ser Asp Ala Ser Gly Phe Gly Tyr Cys Phe Arg Glu Leu 
                245                 250                 255     


Arg Gly Gly Glu Cys Ala Ser Pro Leu Pro Gly Leu Arg Thr Gln Glu 
            260                 265                 270         


Val Cys Cys Arg Gly Ala Gly Leu Ala Trp Gly Val His Asp Cys Gln 
        275                 280                 285             


Leu Cys Ser Glu Arg Leu Gly Asn Ser Glu Arg Val Ser Ala Pro Asp 
    290                 295                 300                 


Gly Pro Cys Pro Thr Gly Phe Glu Arg Val Asn Gly Ser Cys Glu Asp 
305                 310                 315                 320 


Val Asp Glu Cys Ala Thr Gly Gly Arg Cys Gln His Gly Glu Cys Ala 
                325                 330                 335     


Asn Thr Arg Gly Gly Tyr Thr Cys Val Cys Pro Asp Gly Phe Leu Leu 
            340                 345                 350         


Asp Ser Ser Arg Ser Ser Cys Ile Ser Gln His Val Ile Ser Glu Ala 
        355                 360                 365             


Lys Gly Pro Cys Phe Arg Val Leu Arg Asp Gly Gly Cys Ser Leu Pro 
    370                 375                 380                 


Ile Leu Arg Asn Ile Thr Lys Gln Ile Cys Cys Cys Ser Arg Val Gly 
385                 390                 395                 400 


Lys Ala Trp Gly Arg Gly Cys Gln Leu Cys Pro Pro Phe Gly Ser Glu 
                405                 410                 415     


Gly Phe Arg Glu Ile Cys Pro Ala Gly Pro Gly Tyr His Tyr Ser Ala 
            420                 425                 430         


Ser Asp Leu Arg Tyr Asn Thr Arg Pro Leu Gly Gln Glu Pro Pro Arg 
        435                 440                 445             


Val Ser Leu Ser Gln Pro Arg Thr Leu Pro Ala Thr Ser Arg Pro Ser 
    450                 455                 460                 


Ala Gly Phe Leu Pro Thr His Arg Leu Glu Pro Arg Pro Glu Pro Arg 
465                 470                 475                 480 


Pro Asp Pro Arg Pro Gly Pro Glu Leu Pro Leu Pro Ser Ile Pro Ala 
                485                 490                 495     


Trp Thr Gly Pro Glu Ile Pro Glu Ser Gly Pro Ser Ser Gly Met Cys 
            500                 505                 510         


Gln Arg Asn Pro Gln Val Cys Gly Pro Gly Arg Cys Ile Ser Arg Pro 
        515                 520                 525             


Ser Gly Tyr Thr Cys Ala Cys Asp Ser Gly Phe Arg Leu Ser Pro Gln 
    530                 535                 540                 


Gly Thr Arg Cys Ile Asp Val Asp Glu Cys Arg Arg Val Pro Pro Pro 
545                 550                 555                 560 


Cys Ala Pro Gly Arg Cys Glu Asn Ser Pro Gly Ser Phe Arg Cys Val 
                565                 570                 575     


Cys Gly Pro Gly Phe Arg Ala Gly Pro Arg Ala Ala Glu Cys Leu Asp 
            580                 585                 590         


Val Asp Glu Cys His Arg Val Pro Pro Pro Cys Asp Leu Gly Arg Cys 
        595                 600                 605             


Glu Asn Thr Pro Gly Ser Phe Leu Cys Val Cys Pro Ala Gly Tyr Gln 
    610                 615                 620                 


Ala Ala Pro His Gly Ala Ser Cys Gln Asp Val Asp Glu Cys Thr Gln 
625                 630                 635                 640 


Ser Pro Gly Leu Cys Gly Arg Gly Ala Cys Lys Asn Leu Pro Gly Ser 
                645                 650                 655     


Phe Arg Cys Val Cys Pro Ala Gly Phe Arg Gly Ser Ala Cys Glu Glu 
            660                 665                 670         


Asp Val Asp Glu Cys Ala Gln Glu Pro Pro Pro Cys Gly Pro Gly Arg 
        675                 680                 685             


Cys Asp Asn Thr Ala Gly Ser Phe His Cys Ala Cys Pro Ala Gly Phe 
    690                 695                 700                 


Arg Ser Arg Gly Pro Gly Ala Pro Cys Gln Asp Val Asp Glu Cys Ala 
705                 710                 715                 720 


Arg Ser Pro Pro Pro Cys Thr Tyr Gly Arg Cys Glu Asn Thr Glu Gly 
                725                 730                 735     


Ser Phe Gln Cys Val Cys Pro Met Gly Phe Gln Pro Asn Thr Ala Gly 
            740                 745                 750         


Ser Glu Cys Glu Asp Val Asp Glu Cys Glu Asn His Leu Ala Cys Pro 
        755                 760                 765             


Gly Gln Glu Cys Val Asn Ser Pro Gly Ser Phe Gln Cys Arg Thr Cys 
    770                 775                 780                 


Pro Ser Gly His His Leu His Arg Gly Arg Cys Thr Asp Val Asp Glu 
785                 790                 795                 800 


Cys Ser Ser Gly Ala Pro Pro Cys Gly Pro His Gly His Cys Thr Asn 
                805                 810                 815     


Thr Glu Gly Ser Phe Arg Cys Ser Cys Ala Pro Gly Tyr Arg Ala Pro 
            820                 825                 830         


Ser Gly Arg Pro Gly Pro Cys Ala Asp Val Asn Glu Cys Leu Glu Gly 
        835                 840                 845             


Asp Phe Cys Phe Pro His Gly Glu Cys Leu Asn Thr Asp Gly Ser Phe 
    850                 855                 860                 


Ala Cys Thr Cys Ala Pro Gly Tyr Arg Pro Gly Pro Arg Gly Ala Ser 
865                 870                 875                 880 


Cys Leu Asp Val Asp Glu Cys Ser Glu Glu Asp Leu Cys Gln Ser Gly 
                885                 890                 895     


Ile Cys Thr Asn Thr Asp Gly Ser Phe Glu Cys Ile Cys Pro Pro Gly 
            900                 905                 910         


His Arg Ala Gly Pro Asp Leu Ala Ser Cys Leu Asp Val Asp Glu Cys 
        915                 920                 925             


Arg Glu Arg Gly Pro Ala Leu Cys Gly Ser Gln Arg Cys Glu Asn Ser 
    930                 935                 940                 


Pro Gly Ser Tyr Arg Cys Val Arg Asp Cys Asp Pro Gly Tyr His Ala 
945                 950                 955                 960 


Gly Pro Glu Gly Thr Cys Asp Asp Val Asp Glu Cys Gln Glu Tyr Gly 
                965                 970                 975     


Pro Glu Ile Cys Gly Ala Gln Arg Cys Glu Asn Thr Pro Gly Ser Tyr 
            980                 985                 990         


Arg Cys Thr Pro Ala Cys Asp Pro  Gly Tyr Gln Pro Thr  Pro Gly Gly 
        995                 1000                 1005             


Gly Cys  Gln Asp Val Asp Glu  Cys Arg Asn Arg Ser  Phe Cys Gly 
    1010                 1015                 1020             


Ala His  Ala Val Cys Gln Asn  Leu Pro Gly Ser Phe  Gln Cys Leu 
    1025                 1030                 1035             


Cys Asp  Gln Gly Tyr Glu Gly  Ala Arg Asp Gly Arg  His Cys Val 
    1040                 1045                 1050             


Asp Val  Asn Glu Cys Glu Thr  Leu Gln Gly Val Cys  Gly Ala Ala 
    1055                 1060                 1065             


Leu Cys  Glu Asn Val Glu Gly  Ser Phe Leu Cys Val  Cys Pro Asn 
    1070                 1075                 1080             


Ser Pro  Glu Glu Phe Asp Pro  Met Thr Gly Arg Cys  Val Pro Pro 
    1085                 1090                 1095             


Arg Thr  Ser Ala Gly Thr Phe  Pro Gly Ser Gln Pro  Gln Ala Pro 
    1100                 1105                 1110             


Ala Ser  Pro Val Leu Pro Ala  Arg Pro Pro Pro Pro  Pro Leu Pro 
    1115                 1120                 1125             


Arg Arg  Pro Ser Thr Pro Arg  Gln Gly Pro Val Gly  Ser Gly Arg 
    1130                 1135                 1140             


Arg Glu  Cys Tyr Phe Asp Thr  Ala Ala Pro Asp Ala  Cys Asp Asn 
    1145                 1150                 1155             


Ile Leu  Ala Arg Asn Val Thr  Trp Gln Glu Cys Cys  Cys Thr Val 
    1160                 1165                 1170             


Gly Glu  Gly Trp Gly Ser Gly  Cys Arg Ile Gln Gln  Cys Pro Gly 
    1175                 1180                 1185             


Thr Glu  Thr Ala Glu Tyr Gln  Ser Leu Cys Pro His  Gly Arg Gly 
    1190                 1195                 1200             


Tyr Leu  Ala Pro Ser Gly Asp  Leu Ser Leu Arg Arg  Asp Val Asp 
    1205                 1210                 1215             


Glu Cys  Gln Leu Phe Arg Asp  Gln Val Cys Lys Ser  Gly Val Cys 
    1220                 1225                 1230             


Val Asn  Thr Ala Pro Gly Tyr  Ser Cys Tyr Cys Ser  Asn Gly Tyr 
    1235                 1240                 1245             


Tyr Tyr  His Thr Gln Arg Leu  Glu Cys Ile Asp Asn  Asp Glu Cys 
    1250                 1255                 1260             


Ala Asp  Glu Glu Pro Ala Cys  Glu Gly Gly Arg Cys  Val Asn Thr 
    1265                 1270                 1275             


Val Gly  Ser Tyr His Cys Thr  Cys Glu Pro Pro Leu  Val Leu Asp 
    1280                 1285                 1290             


Gly Ser  Gln Arg Arg Cys Val  Ser Asn Glu Ser Gln  Ser Leu Asp 
    1295                 1300                 1305             


Asp Asn  Leu Gly Val Cys Trp  Gln Glu Val Gly Ala  Asp Leu Val 
    1310                 1315                 1320             


Cys Ser  His Pro Arg Leu Asp  Arg Gln Ala Thr Tyr  Thr Glu Cys 
    1325                 1330                 1335             


Cys Cys  Leu Tyr Gly Glu Ala  Trp Gly Met Asp Cys  Ala Leu Cys 
    1340                 1345                 1350             


Pro Ala  Gln Asp Ser Asp Asp  Phe Glu Ala Leu Cys  Asn Val Leu 
    1355                 1360                 1365             


Arg Pro  Pro Ala Tyr Ser Pro  Pro Arg Pro Gly Gly  Phe Gly Leu 
    1370                 1375                 1380             


Pro Tyr  Glu Tyr Gly Pro Asp  Leu Gly Pro Pro Tyr  Gln Gly Leu 
    1385                 1390                 1395             


Pro Tyr  Gly Pro Glu Leu Tyr  Pro Pro Pro Ala Leu  Pro Tyr Asp 
    1400                 1405                 1410             


Pro Tyr  Pro Pro Pro Pro Gly  Pro Phe Ala Arg Arg  Glu Ala Pro 
    1415                 1420                 1425             


Tyr Gly  Ala Pro Arg Phe Asp  Met Pro Asp Phe Glu  Asp Asp Gly 
    1430                 1435                 1440             


Gly Pro  Tyr Gly Glu Ser Glu  Ala Pro Ala Pro Pro  Gly Pro Gly 
    1445                 1450                 1455             


Thr Arg  Trp Pro Tyr Arg Ser  Arg Asp Thr Arg Arg  Ser Phe Pro 
    1460                 1465                 1470             


Glu Pro  Glu Glu Pro Pro Glu  Gly Gly Ser Tyr Ala  Gly Ser Leu 
    1475                 1480                 1485             


Ala Glu  Pro Tyr Glu Glu Leu  Glu Ala Glu Glu Cys  Gly Ile Leu 
    1490                 1495                 1500             


Asp Gly  Cys Thr Asn Gly Arg  Cys Val Arg Val Pro  Glu Gly Phe 
    1505                 1510                 1515             


Thr Cys  Arg Cys Phe Asp Gly  Tyr Arg Leu Asp Met  Thr Arg Met 
    1520                 1525                 1530             


Ala Cys  Val Asp Ile Asn Glu  Cys Asp Glu Ala Glu  Ala Ala Ser 
    1535                 1540                 1545             


Pro Leu  Cys Val Asn Ala Arg  Cys Leu Asn Thr Asp  Gly Ser Phe 
    1550                 1555                 1560             


Arg Cys  Ile Cys Arg Pro Gly  Phe Ala Pro Thr His  Gln Pro His 
    1565                 1570                 1575             


His Cys  Ala Pro Ala Arg Pro  Arg Ala 
    1580                 1585         


