                         SEQUENCE LISTING

<110>  Codexis, Inc.
       Behrouzian, Behnaz
       Clark, Louis
       Zhu, Yihui
       Clay, Michael
       Karlshoej, Kristian
 
<120>  Fatty Alcohol Forming Acyl Reductases (FARS) and Methods of Use 
       Thereof

<130>  90834-804539

<140>  PCT/US2011/042238
<141>  2011-06-28

<150>  US 61/359,211
<151>  2010-06-28

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1539
<212>  DNA
<213>  Marinobacter algicola

<400>  1
atggctactc aacaacaaca gaacggtgca tctgcatccg gcgtcttgga acaacttcgt       60

ggaaagcacg ttcttatcac aggtactacc ggatttttgg gcaaagtggt tctggaaaag      120

ttgattcgta ctgttccgga tattggaggt attcatctgc tgattcgtgg caataaacgt      180

catccagccg ctcgtgaacg tttcctgaac gaaattgcgt cctcctccgt cttcgaacgt      240

ttgcgtcacg atgataatga agccttcgag accttcttgg aagaacgtgt tcactgtatt      300

accggtgagg ttactgaatc ccgttttggt ttgacacctg aacgttttcg tgctttggcc      360

ggtcaggttg acgcttttat taacagcgct gcaagcgtga actttcgtga ggaattggat      420

aaagccctga aaatcaacac cttgtgtctt gaaaatgttg ctgctcttgc agaattgaac      480

tccgctatgg cggtcattca ggtttccact tgttacgtta acggtaaaaa ctccggtcaa      540

attaccgaat ccgtcattaa acctgctggc gaatccattc cccgttccac tgacggttac      600

tacgagatcg aagaattggt ccatctgttg caagacaaga tttccgatgt taaagctcgt      660

tactccggca aagttctgga gaaaaaattg gttgatttgg gtattcgtga ggccaataat      720

tacggatggt ccgacaccta cacattcacc aaatggttgg gtgaacaact gctgatgaag      780

gccttgtctg gtcgttcttt gactattgtg cgtccctcta ttattgagtc cgctttggaa      840

gaaccttccc ctggttggat cgaaggcgtt aaagttgccg atgccattat cttggcttat      900

gcccgtgaaa aagttagcct gttccctgga aaacgttccg gcattattga tgttattcct      960

gtcgatttgg ttgcgaactc catcatcttg tctctggctg aggcgttgtc tggttctggt     1020

caacgtcgta tttatcaatg ttgcagcggt ggttctaatc caatctccct gggtaagttc     1080

attgattatt tgatggccga ggctaagacc aactatgctg cctacgatca actgttttat     1140

cgtcgtccta ctaaaccttt cgtcgccgtg aaccgtaaat tgtttgacgt tgttgttggt     1200

ggtatgcgtg ttcctctttc tattgccggt aaagctatgc gtttggctgg tcaaaatcgt     1260

gagttgaaag tgcttaagaa ccttgatacg acccgttccc ttgcaaccat ttttggcttc     1320

tatactgctc ccgactatat cttccgtaac gatagcttga tggccctggc ttctcgtatg     1380

ggtgaattgg atcgtgttct tttcccagtt gatgctcgtc aaattgattg gcagttgtac     1440

ttgtgtaaaa ttcatttggg tggtctgaac cgttacgctt tgaaggaacg taaactgtat     1500

tctttgcgtg ctgctgatac tcgtaaaaaa gctgcctaa                            1539


<210>  2
<211>  512
<212>  PRT
<213>  Marinobacter algicola

<400>  2

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Pro Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Pro Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Gln Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Ser Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Leu Arg Ala Ala Asp Thr Arg Lys Lys Ala Ala 
            500                 505                 510         


<210>  3
<211>  1539
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA codon optimized encoding M. Algicola DG893 FAR

<400>  3
atggccaccc agcagcagca gaacggtgca tccgcttcgg gcgttctgga gcagcttaga       60

ggcaagcatg tcttgattac cggtactaca ggatttctgg gaaaggtggt tctggagaag      120

ctgatccgaa ccgtgcctga catcggtggt attcatctgc tgattagagg caacaagaga      180

catcctgctg ccagagaaag attcttgaac gaaatcgcct cttcctctgt gttcgagcgg      240

cttagacatg acgacaacga agcctttgag actttcctgg aggagcgtgt gcactgcatc      300

accggagaag tgaccgagtc gagatttggc cttactcctg agcggttccg agcccttgct      360

ggccaagtgg atgccttcat caattccgcc gcctctgtta acttcagaga ggagctggac      420

aaggcactca agatcaacac cctgtgtctg gagaacgtgg ctgctctggc cgaacttaac      480

tccgctatgg cagtgatcca agtttccacc tgttacgtga acggcaagaa ctctggacag      540

atcaccgagt ccgttatcaa gcccgctggc gaatccatcc ccagatccac agatggctac      600

tacgagatcg aggagctggt ccaccttctg caagacaaga tctccgacgt gaaggctcga      660

tactctggca aggtgttgga gaagaagctg gtggacctgg gcatccgaga ggcgaacaac      720

tacggctggt ctgacaccta caccttcacc aaatggctcg gagagcagct tctgatgaaa      780

gctctgtccg gaagatccct gactatcgtg cggccttcca tcatcgagtc ggctcttgaa      840

gagccttctc caggttggat cgagggcgtg aaggttgctg acgccatcat ccttgcgtac      900

gccagagaga aggtttcgtt gttccccggc aagcgatctg gcatcatcga cgttatcccc      960

gtggatctgg tggccaactc tatcattctc tctcttgctg aagccctttc tggatctggc     1020

cagcgtagaa tctaccaatg ttgttctggc ggttctaacc cgatttctct gggcaagttc     1080

atcgactacc ttatggccga agccaagacc aactatgctg cctacgacca gctcttctac     1140

cgacgaccca ccaagccctt cgtcgctgtg aaccgaaagc tgttcgatgt tgtcgtggga     1200

ggaatgcgag tgcctctttc cattgctggc aaggccatga gattggcggg tcagaatcga     1260

gaattgaagg ttctcaagaa ccttgacact actcgatcgc tcgctactat ctttggattc     1320

tacactgctc ctgactacat cttccggaat gactctctga tggctcttgc ttcccgaatg     1380

ggagaactcg atcgtgtgct gttccctgtt gacgctcgac agatcgactg gcagctctac     1440

ttgtgtaaga tccacctggg cggcctgaac cgatatgctc tgaaagaacg aaagctgtac     1500

agccttagag ccgctgatac ccgaaagaag gctgcttaa                            1539


<210>  4
<211>  1542
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic DNA codon optimized encoding M. aquaeolei FAR

<400>  4
atggctatcc agcaggttca tcacgccgac acatcctcct ctaaagtcct gggtcaactt       60

cgtggtaaac gtgtcttgat taccggcact actggattct tgggtaaagt cgtcttggaa      120

cgtttgattc gtgccgttcc tgacatcggt gctatctacc tgctgattcg tggtaacaag      180

cgtcacccgg atgctcgttc tcgtttcttg gaggagattg ctacctcctc tgtctttgat      240

cgtttgcgtg aagctgattc cgaaggtttc gatgctttcc tggaagaacg tattcactgt      300

gttactggtg aagttactga agctggtttc ggtattggtc aagaggacta tcgtaagttg      360

gccaccgaat tggacgcagt catcaattct gctgcctccg tcaacttccg tgaggagttg      420

gataaggctc tggccatcaa cactctgtgt ttgcgtaaca tcgctggtat ggtggatctt      480

aaccctaagc tggccgttct tcaagtctct acgtgttacg tcaacggtat gaactctggt      540

caagttactg aatccgtcat caaaccagct ggtgaagctg ttcctcgttc tcctgatgga      600

ttctacgaga tcgaggaatt ggttcgtctg ctgcaagaca agattgaaga cgttcaagca      660

cgttactctg gtaaggtgtt ggagcgtaag ttggttgatt tgggtattcg tgaggctaat      720

cgttacggtt ggtctgatac atacaccttc acgaaatggt tgggtgaaca acttctgatg      780

aaagccttga atggtcgtac cttgactatt ctgcgtccta gcatcattga atctgctttg      840

gaagaaccag cacctggttg gattgaaggc gtgaaagttg cagatgcgat catcttggct      900

tatgctcgtg agaaggttac tttgtttccg ggtaaacgtt ctggtatcat tgatgtgatt      960

cctgttgact tggttgccaa ttccatcatc ttgtctttgg ctgaggctct gggcgaacct     1020

ggtcgtcgtc gtatctacca atgttgttct ggtggtggta atcctatctc cctgggcgag     1080

ttcattgatc acctgatggc tgaatccaaa gccaactatg ccgcatacga tcatctgttc     1140

taccgtcaac cctccaagcc tttccttgct gtcaaccgtg ctttgttcga cttggttatc     1200

tctggtgtcc gtctgccttt gtctttgacc gaccgtgtct tgaagctgct gggcaactcc     1260

cgtgacctga agatgctgcg taacctggat actacgcaat ccctggctac tatctttggc     1320

ttctacacag cccccgacta catcttccgt aatgacgagt tgatggccct ggctaaccgt     1380

atgggcgagg ttgataaggg tttgttcccc gttgatgctc gtctgattga ttgggaattg     1440

tacctgcgta agattcacct ggctggtttg aaccgttacg ccttgaagga gcgtaaggtt     1500

tactctttga agacagcccg tcagcgtaag aaggcagctt aa                        1542


<210>  5
<211>  513
<212>  PRT
<213>  Marinobacter aquaeolei

<400>  5

Met Ala Ile Gln Gln Val His His Ala Asp Thr Ser Ser Ser Lys Val 
1               5                   10                  15      


Leu Gly Gln Leu Arg Gly Lys Arg Val Leu Ile Thr Gly Thr Thr Gly 
            20                  25                  30          


Phe Leu Gly Lys Val Val Leu Glu Arg Leu Ile Arg Ala Val Pro Asp 
        35                  40                  45              


Ile Gly Ala Ile Tyr Leu Leu Ile Arg Gly Asn Lys Arg His Pro Asp 
    50                  55                  60                  


Ala Arg Ser Arg Phe Leu Glu Glu Ile Ala Thr Ser Ser Val Phe Asp 
65                  70                  75                  80  


Arg Leu Arg Glu Ala Asp Ser Glu Gly Phe Asp Ala Phe Leu Glu Glu 
                85                  90                  95      


Arg Ile His Cys Val Thr Gly Glu Val Thr Glu Ala Gly Phe Gly Ile 
            100                 105                 110         


Gly Gln Glu Asp Tyr Arg Lys Leu Ala Thr Glu Leu Asp Ala Val Ile 
        115                 120                 125             


Asn Ser Ala Ala Ser Val Asn Phe Arg Glu Glu Leu Asp Lys Ala Leu 
    130                 135                 140                 


Ala Ile Asn Thr Leu Cys Leu Arg Asn Ile Ala Gly Met Val Asp Leu 
145                 150                 155                 160 


Asn Pro Lys Leu Ala Val Leu Gln Val Ser Thr Cys Tyr Val Asn Gly 
                165                 170                 175     


Met Asn Ser Gly Gln Val Thr Glu Ser Val Ile Lys Pro Ala Gly Glu 
            180                 185                 190         


Ala Val Pro Arg Ser Pro Asp Gly Phe Tyr Glu Ile Glu Glu Leu Val 
        195                 200                 205             


Arg Leu Leu Gln Asp Lys Ile Glu Asp Val Gln Ala Arg Tyr Ser Gly 
    210                 215                 220                 


Lys Val Leu Glu Arg Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn 
225                 230                 235                 240 


Arg Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu 
                245                 250                 255     


Gln Leu Leu Met Lys Ala Leu Asn Gly Arg Thr Leu Thr Ile Leu Arg 
            260                 265                 270         


Pro Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ala Pro Gly Trp Ile 
        275                 280                 285             


Glu Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu 
    290                 295                 300                 


Lys Val Thr Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile 
305                 310                 315                 320 


Pro Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala 
                325                 330                 335     


Leu Gly Glu Pro Gly Arg Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly 
            340                 345                 350         


Gly Asn Pro Ile Ser Leu Gly Glu Phe Ile Asp His Leu Met Ala Glu 
        355                 360                 365             


Ser Lys Ala Asn Tyr Ala Ala Tyr Asp His Leu Phe Tyr Arg Gln Pro 
    370                 375                 380                 


Ser Lys Pro Phe Leu Ala Val Asn Arg Ala Leu Phe Asp Leu Val Ile 
385                 390                 395                 400 


Ser Gly Val Arg Leu Pro Leu Ser Leu Thr Asp Arg Val Leu Lys Leu 
                405                 410                 415     


Leu Gly Asn Ser Arg Asp Leu Lys Met Leu Arg Asn Leu Asp Thr Thr 
            420                 425                 430         


Gln Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile 
        435                 440                 445             


Phe Arg Asn Asp Glu Leu Met Ala Leu Ala Asn Arg Met Gly Glu Val 
    450                 455                 460                 


Asp Lys Gly Leu Phe Pro Val Asp Ala Arg Leu Ile Asp Trp Glu Leu 
465                 470                 475                 480 


Tyr Leu Arg Lys Ile His Leu Ala Gly Leu Asn Arg Tyr Ala Leu Lys 
                485                 490                 495     


Glu Arg Lys Val Tyr Ser Leu Lys Thr Ala Arg Gln Arg Lys Lys Ala 
            500                 505                 510         


Ala 
    


<210>  6
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 370

<400>  6

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Ser Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Leu Arg Ala Ala Asp Thr Arg Lys Lys Thr Ala 
            500                 505                 510         


<210>  7
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 391

<400>  7

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Gln Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Ser Arg Ala Ala Asp Thr Asp Asp Lys Thr Ala 
            500                 505                 510         


<210>  8
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 436

<400>  8

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Lys Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Ser Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Gln Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Ser Arg Ala Ala Asp Thr Asp Asp Lys Thr Ala 
            500                 505                 510         


<210>  9
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 438

<400>  9

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile Asn 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Lys Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Gln Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Ser Arg Ala Ala Asp Thr Asp Asp Lys Thr Ala 
            500                 505                 510         


<210>  10
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 547

<400>  10

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Gln Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile His 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Cys Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Met Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Cys Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Lys Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Gln Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Ser Arg Ala Ala Asp Thr Asp Asp Lys Thr Ala 
            500                 505                 510         


<210>  11
<211>  511
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 555

<400>  11

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Ile Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Arg Ala 
    50                  55                  60                  


Gly Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile His 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Asn Gly Lys 
                165                 170                 175     


Asn Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Leu Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Gly Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Lys Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Gln Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Arg Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Ser Arg Ala Ala Asp Thr Asp Asp Lys Thr 
            500                 505                 510     


<210>  12
<211>  512
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide of FAR Maa variant 556

<400>  12

Met Ala Thr Gln Gln Gln Gln Asn Gly Ala Ser Ala Ser Gly Val Leu 
1               5                   10                  15      


Glu Ile Leu Arg Gly Lys His Val Leu Ile Thr Gly Thr Thr Gly Phe 
            20                  25                  30          


Leu Gly Lys Val Val Leu Glu Lys Leu Ile Arg Thr Val Pro Asp Ile 
        35                  40                  45              


Gly Gly Ile His Leu Leu Ile Arg Gly Asn Lys Arg His Pro Ala Ala 
    50                  55                  60                  


Arg Glu Arg Phe Leu Asn Glu Ile Ala Ser Ser Ser Val Phe Glu Arg 
65                  70                  75                  80  


Leu Arg His Asp Asp Asn Glu Ala Phe Glu Thr Phe Leu Glu Glu Arg 
                85                  90                  95      


Val His Cys Ile Thr Gly Glu Val Thr Glu Ser Arg Phe Gly Leu Thr 
            100                 105                 110         


Pro Glu Arg Phe Arg Ala Leu Ala Gly Gln Val Asp Ala Phe Ile His 
        115                 120                 125             


Ser Ala Ala Ser Val Ser Phe Arg Glu Gln Leu Asp Lys Ala Leu Lys 
    130                 135                 140                 


Ile Asn Thr Leu Cys Leu Glu Asn Val Ala Ala Leu Ala Glu Leu Asn 
145                 150                 155                 160 


Ser Ala Met Ala Val Ile Gln Val Ser Thr Cys Tyr Val Cys Gly Lys 
                165                 170                 175     


Thr Ser Gly Gln Ile Thr Glu Ser Val Ile Lys Ser Ala Gly Glu Ser 
            180                 185                 190         


Ile Pro Arg Ser Thr Asp Gly Tyr Tyr Glu Ile Glu Glu Leu Val His 
        195                 200                 205             


Leu Leu Gln Asp Lys Ile Ser Asp Val Lys Ala Arg Tyr Ser Gly Lys 
    210                 215                 220                 


Val Met Glu Lys Lys Leu Val Asp Leu Gly Ile Arg Glu Ala Asn Asn 
225                 230                 235                 240 


Tyr Gly Trp Ser Asp Thr Tyr Thr Phe Thr Lys Trp Leu Gly Glu Gln 
                245                 250                 255     


Leu Leu Met Lys Ala Leu Ser Gly Arg Ser Leu Thr Ile Val Arg Pro 
            260                 265                 270         


Ser Ile Ile Glu Ser Ala Leu Glu Glu Pro Ser Pro Gly Trp Ile Glu 
        275                 280                 285             


Gly Val Lys Val Ala Asp Ala Ile Ile Leu Ala Tyr Ala Arg Glu Lys 
    290                 295                 300                 


Val Ser Leu Phe Pro Gly Lys Arg Ser Gly Ile Ile Asp Val Ile Pro 
305                 310                 315                 320 


Val Asp Leu Val Ala Asn Ser Ile Ile Leu Ser Leu Ala Glu Ala Leu 
                325                 330                 335     


Ser Gly Ser Gly Gln Arg Arg Ile Tyr Gln Cys Cys Ser Gly Cys Ser 
            340                 345                 350         


Asn Pro Ile Ser Leu Gly Lys Phe Ile Asp Tyr Leu Met Ala Glu Ala 
        355                 360                 365             


Lys Thr Asn Tyr Ala Ala Tyr Asp Gln Leu Phe Tyr Arg Arg Pro Thr 
    370                 375                 380                 


Lys Pro Phe Val Ala Val Asn Arg Lys Leu Phe Asp Val Val Val Gly 
385                 390                 395                 400 


Gly Met Arg Val Val Leu Ser Ile Ala Gly Lys Ala Met Arg Leu Ala 
                405                 410                 415     


Gly Val Asn Arg Glu Leu Lys Val Leu Lys Asn Leu Asp Thr Thr Arg 
            420                 425                 430         


Lys Leu Ala Thr Ile Phe Gly Phe Tyr Thr Ala Pro Asp Tyr Ile Phe 
        435                 440                 445             


Arg Asn Asp Ser Leu Met Ala Leu Ala Gln Arg Met Gly Glu Leu Asp 
    450                 455                 460                 


Arg Val Leu Phe Pro Val Asp Ala Arg Gln Ile Asp Trp Gln Leu Tyr 
465                 470                 475                 480 


Leu Cys Lys Ile His Leu Gly Gly Leu Asn Arg Tyr Ala Leu Lys Glu 
                485                 490                 495     


Arg Lys Leu Tyr Ser Ser Arg Ala Ala Asp Thr Asp Asp Lys Thr Ala 
            500                 505                 510         


<210>  13
<211>  1536
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic DNA of cDNA for Marinobacter algicola DG893 (FAR Maa) 
       wild-type

<400>  13
atggcaacac agcagcaaca aaacggagcg tcagcgtccg gtgttcttga gcaactacgt       60

ggtaaacacg tgctgatcac cggcaccacc gggtttcttg gtaaggtggt actggaaaaa      120

ttgattcgca cggtgccgga tattggcggg atccatcttc ttatccgtgg taacaaaagg      180

catcctgcag cacgggaacg attcctcaac gagatcgcca gttcttccgt gttcgaacgc      240

cttcggcacg atgacaacga ggcgtttgaa acctttcttg aggaacgcgt tcactgcatc      300

accggcgaag tgacagagtc gcgtttcggg ctcacgccgg agcggttccg tgcacttgcc      360

gggcaggtcg atgcgtttat aaattccgca gccagtgtga acttccggga ggaactcgac      420

aaggcgctga agattaacac cctgtgcctg gagaacgttg ccgctctggc ggagctcaat      480

agcgccatgg cggttatcca ggtgtccacc tgctacgtca atggcaagaa ttccggccag      540

atcacggagt ccgtcatcaa gccggcgggc gagtctattc cccgcagcac cgacggctac      600

tatgaaatcg aagagcttgt gcatttgctg caggacaaaa tttccgacgt gaaagcccga      660

tactccggca aagtacttga aaaaaagctg gtggacctgg ggattcgaga ggccaacaac      720

tacggctgga gtgacaccta cacgtttacc aaatggctgg gtgagcaact cctgatgaaa      780

gccctttccg ggcgttcact tacgattgtt cgcccttcca tcattgaaag tgcactggaa      840

gagccttcgc caggatggat tgaaggtgtg aaggtggcag acgccattat ccttgcctat      900

gcccgtgaga aggtctccct gttcccaggc aagcgtagcg gcattatcga tgtgatcccg      960

gtggacctgg tggccaacag tatcatcttg tccctggcag aagccctttc cgggtcaggg     1020

cagcgccgca tctatcaatg ctgcagtggc ggttctaatc cgatttcgct gggcaagttc     1080

attgactacc tgatggccga agccaagacc aactatgcag cgtatgacca gttgttctac     1140

cgacggccca cgaaaccgtt tgtggcggtc aatcgcaagc tgtttgatgt tgtggttggc     1200

ggcatgcgcg tgccgttgtc gattgctggc aaggcaatga ggctggctgg ccagaaccgt     1260

gagctcaagg ttctcaaaaa cctcgatacc acgcgttcac tggccaccat ctttggtttc     1320

tacacggcac cggattacat cttccgtaac gattcgctga tggccctggc ttcgcgcatg     1380

ggtgaactgg accgtgtcct gttcccggtg gatgcgcgtc agattgactg gcagctgtac     1440

ttgtgcaaga tccacctggg aggtctcaac cgctacgctc tgaaggagcg aaaactgtac     1500

agcctgcggg ccgccgacac ccgcaaaaaa gccgcc                               1536


<210>  14
<211>  1539
<212>  DNA
<213>  Marinobacter algicola

<400>  14
atggcaatac agcaggtaca tcacgctgac acttcatcat caaaggtgct cggacagctc       60

cgtggcaagc gggttctgat caccggtacc actggctttc tgggcaaggt ggtcctcgaa      120

aggctgattc gggcggtgcc tgatatcggc gcaatttacc tgctgatccg gggcaataaa      180

cggcatccgg atgctcgttc ccgtttcctg gaagaaattg ccacctcctc ggtgtttgac      240

cgtcttcgcg aggccgattc agagggattt gacgcctttc tggaagagcg cattcactgc      300

gtgaccggtg aggtgaccga agcgggtttc gggatagggc aggaagacta tcgcaaactc      360

gccaccgaac tggatgcggt gatcaactcc gctgcaagcg tgaatttccg tgaagagctc      420

gacaaggcgc tggccatcaa caccctgtgc cttcggaata ttgccggcat ggtggatttg      480

aatccgaagc ttgcggtcct gcaggtctcc acctgctatg tcaatggcat gaactcgggg      540

caggtaaccg aatcggtgat caagccggca ggcgaggccg tgccgcgttc cccggacggc      600

ttctatgaga tagaagagct tgttcgcctg cttcaggata aaattgaaga cgttcaggcc      660

cgttattccg gcaaagtgct ggagaggaag ctggtggacc tggggattcg ggaagccaac      720

cgctatggct ggagcgatac ctacaccttt accaagtggc tgggcgaaca gttgctgatg      780

aaggcgttaa acgggcgcac gctgaccatt ctgcgtcctt cgattatcga aagtgccctg      840

gaggaaccag cgcccggctg gattgagggg gtgaaggtgg cagatgccat catcctggct      900

tacgcacggg aaaaagtcac cctcttcccg ggcaaacgct ccggtatcat cgatgtgatt      960

ccagtggacc tggtggccaa ctccatcatc ctttccctgg cggaagctct tggagaaccc     1020

ggtcgacgtc gcatctatca atgttgcagc gggggcggca atccaatctc cctgggtgag     1080

ttcatcgatc atctcatggc ggaatcaaaa gccaattacg ctgcctacga tcacctgttc     1140

taccggcagc ccagcaagcc gtttctggcg gttaaccggg cgctgtttga tttggtgatc     1200

agtggtgttc gcttaccgct ctccctgacg gaccgtgtgc tcaaattact gggaaattcc     1260

cgggacctga aaatgctcag gaatctggat accacccagt cgctggcaac catttttggt     1320

ttctacaccg cgccggatta tatcttccgg aacgatgagc tgatggcgct ggcgaaccgg     1380

atgggtgagg tcgataaagg gctgttcccg gtggatgccc gcctgattga ctgggagctc     1440

tacctgcgca agattcacct ggccgggctc aatcgctatg ccctgaaaga acgaaaggtg     1500

tacagtctga aaaccgcgcg ccagcgcaaa aaagctgcc                            1539


