                         SEQUENCE LISTING

<110>  Oregon Health & Science University
       Offner-Vandenbark, Halina
       Quinn, Joseph
       Subramanian, Sandhya
 
<120>  CCR6 AS A BIOMARKER OF ALZHEIMERS DISEASE

<130>  1525

<150>  61/359,760
<151>  2010-06-29

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  1104
<212>  DNA
<213>  Mus musculus

<400>  1
atgaattcca cagagtccta ctttggaacg gatgattatg acaacacaga gtattattct       60

attcctccag accatgggcc atgctcccta gaagaggtca gaaacttcac caaggtattt      120

gtgccaattg cctactcctt aatatgtgtc tttggcctcc tgggcaacat tatggtggtg      180

atgacctttg ccttctacaa gaaagccaga tccatgactg acgtctacct gttgaacatg      240

gccatcacag acatactctt tgtcctcacc ctaccgttct gggcagttac tcatgccacc      300

aacacttggg ttttcagcga tgcactgtgt aaactgatga aaggcacata tgcggtcaac      360

tttaactgtg ggatgctgct cctggcctgt atcagcatgg accggtacat tgccatcgtc      420

caggcaacca aatctttccg ggtacgctcc agaacactga cgcacagtaa ggtcatctgt      480

gtggcagtgt ggttcatctc catcatcatc tcaagcccta catttatctt caacaagaaa      540

tacgagctgc aggatcgtga tgtctgtgag ccacggtaca ggtctgtctc agagcccatc      600

acgtggaagc tgctgggtat gggactggag ctgttctttg ggttcttcac ccctttgctg      660

tttatggtgt tctgctatct gttcattatc aagaccttgg tgcaggccca gaactccaag      720

aggcacagag ccatccgagt cgtgatcgct gtggttctcg tgttcctggc ttgtcagatc      780

cctcacaaca tggtcctcct cgtgactgcg gtcaacacgg gcaaagtggg ccggagctgc      840

agcaccgaga aagtcctcgc ctacaccagg aacgtggccg aggtcctggc tttcctgcat      900

tgctgcctca accccgtgtt gtatgcgttt attggacaga aattcagaaa ctacttcatg      960

aagatcatga aggatgtgtg gtgtatgaga aggaagaata agatgcctgg cttcctctgt     1020

gcccgggttt actcggaaag ctacatctcc aggcagacca gtgagaccgt cgaaaatgat     1080

aatgcatcgt cctttaccat gtaa                                            1104


<210>  2
<211>  367
<212>  PRT
<213>  Mus musculus

<400>  2

Met Asn Ser Thr Glu Ser Tyr Phe Gly Thr Asp Asp Tyr Asp Asn Thr 
1               5                   10                  15      


Glu Tyr Tyr Ser Ile Pro Pro Asp His Gly Pro Cys Ser Leu Glu Glu 
            20                  25                  30          


Val Arg Asn Phe Thr Lys Val Phe Val Pro Ile Ala Tyr Ser Leu Ile 
        35                  40                  45              


Cys Val Phe Gly Leu Leu Gly Asn Ile Met Val Val Met Thr Phe Ala 
    50                  55                  60                  


Phe Tyr Lys Lys Ala Arg Ser Met Thr Asp Val Tyr Leu Leu Asn Met 
65                  70                  75                  80  


Ala Ile Thr Asp Ile Leu Phe Val Leu Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Thr His Ala Thr Asn Thr Trp Val Phe Ser Asp Ala Leu Cys Lys Leu 
            100                 105                 110         


Met Lys Gly Thr Tyr Ala Val Asn Phe Asn Cys Gly Met Leu Leu Leu 
        115                 120                 125             


Ala Cys Ile Ser Met Asp Arg Tyr Ile Ala Ile Val Gln Ala Thr Lys 
    130                 135                 140                 


Ser Phe Arg Val Arg Ser Arg Thr Leu Thr His Ser Lys Val Ile Cys 
145                 150                 155                 160 


Val Ala Val Trp Phe Ile Ser Ile Ile Ile Ser Ser Pro Thr Phe Ile 
                165                 170                 175     


Phe Asn Lys Lys Tyr Glu Leu Gln Asp Arg Asp Val Cys Glu Pro Arg 
            180                 185                 190         


Tyr Arg Ser Val Ser Glu Pro Ile Thr Trp Lys Leu Leu Gly Met Gly 
        195                 200                 205             


Leu Glu Leu Phe Phe Gly Phe Phe Thr Pro Leu Leu Phe Met Val Phe 
    210                 215                 220                 


Cys Tyr Leu Phe Ile Ile Lys Thr Leu Val Gln Ala Gln Asn Ser Lys 
225                 230                 235                 240 


Arg His Arg Ala Ile Arg Val Val Ile Ala Val Val Leu Val Phe Leu 
                245                 250                 255     


Ala Cys Gln Ile Pro His Asn Met Val Leu Leu Val Thr Ala Val Asn 
            260                 265                 270         


Thr Gly Lys Val Gly Arg Ser Cys Ser Thr Glu Lys Val Leu Ala Tyr 
        275                 280                 285             


Thr Arg Asn Val Ala Glu Val Leu Ala Phe Leu His Cys Cys Leu Asn 
    290                 295                 300                 


Pro Val Leu Tyr Ala Phe Ile Gly Gln Lys Phe Arg Asn Tyr Phe Met 
305                 310                 315                 320 


Lys Ile Met Lys Asp Val Trp Cys Met Arg Arg Lys Asn Lys Met Pro 
                325                 330                 335     


Gly Phe Leu Cys Ala Arg Val Tyr Ser Glu Ser Tyr Ile Ser Arg Gln 
            340                 345                 350         


Thr Ser Glu Thr Val Glu Asn Asp Asn Ala Ser Ser Phe Thr Met 
        355                 360                 365         


<210>  3
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  3
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg       60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag      120

gtcaggcagt tctccaggct atttgtaccg attgcctact ccttgatctg tgtctttggc      180

ctcctgggga atattctggt ggtgatcacc tttgcttttt ataagaaggc caggtctatg      240

acagacgtct atctcttgaa catggccatt gcagacatcc tctttgttct tactctccca      300

ttctgggcag tgagtcatgc caccggtgcg tgggttttca gcaatgccac gtgcaagttg      360

ctaaaaggca tctatgccat caactttaac tgcgggatgc tgctcctgac ttgcattagc      420

atggaccggt acatcgccat tgtacaggcg actaagtcat tccggctccg atccagaaca      480

ctaccgcgca gcaaaatcat ctgccttgtt gtgtgggggc tgtcagtcat catctccagc      540

tcaacttttg tcttcaacca aaaatacaac acccaaggca gcgatgtctg tgaacccaag      600

taccagactg tctcggagcc catcaggtgg aagctgctga tgttggggct tgagctactc      660

tttggtttct ttatcccttt gatgttcatg atattttgtt acacgttcat tgtcaaaacc      720

ttggtgcaag ctcagaattc taaaaggcac aaagccatcc gtgtaatcat agctgtggtg      780

cttgtgtttc tggcttgtca gattcctcat aacatggtcc tgcttgtgac ggctgcaaat      840

ttgggtaaaa tgaaccgatc ctgccagagc gaaaagctaa ttggctatac gaaaactgtc      900

acagaagtcc tggctttcct gcactgctgc ctgaaccctg tgctctacgc ttttattggg      960

cagaagttca gaaactactt tctgaagatc ttgaaggacc tgtggtgtgt gagaaggaag     1020

tacaagtcct caggcttctc ctgtgccggg aggtactcag aaaacatttc tcggcagacc     1080

agtgagaccg cagataacga caatgcgtcg tccttcacta tgtga                     1125


<210>  4
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide primer

<400>  5
ttgaaggacc tgtggtgtgt                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  6
ttgtcgttat ctgcggtctc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  7
cctcccggca caggagaagc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  8
ggtgagctgg agtcatcaga                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  9
gtgactctca ggcagtgctc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  10
ccttcagcct cactccgggc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  11
gaccagtgag accgcagata                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  12
tcacacatgc cttagggaga                                                   20


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  13
cgacaatgcg tcgtccttca ctatg                                             25


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  14
gaggtcaggc agttctccag                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  15
gctgccttgg gtgttgtatt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  16
caggaggtca ggcagttctc                                                   20


<210>  17
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  17
ggctgcaatt tgggtaaaa                                                    19


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  18
cacaggagaa gcctgaggac                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  19
gaggtcaggc agttctccag                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  20
ggatggcttt gtgcctttta                                                   20


<210>  21
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  21
accgccgaga ccgcgtccgc cccgcgagca cagagcctcg cctttgccga tccgccgccc       60

gtccacaccc gccgccagct caccatggat gatgatatcg ccgcgctcgt cgtcgacaac      120

ggctccggca tgtgcaaggc cggcttcgcg ggcgacgatg ccccccgggc cgtcttcccc      180

tccatcgtgg ggcgccccag gcaccagggc gtgatggtgg gcatgggtca gaaggattcc      240

tatgtgggcg acgaggccca gagcaagaga ggcatcctca ccctgaagta ccccatcgag      300

cacggcatcg tcaccaactg ggacgacatg gagaaaatct ggcaccacac cttctacaat      360

gagctgcgtg tggctcccga ggagcacccc gtgctgctga ccgaggcccc cctgaacccc      420

aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac cccagccatg      480

tacgttgcta tccaggctgt gctatccctg tacgcctctg gccgtaccac tggcatcgtg      540

atggactccg gtgacggggt cacccacact gtgcccatct acgaggggta tgccctcccc      600

catgccatcc tgcgtctgga cctggctggc cgggacctga ctgactacct catgaagatc      660

ctcaccgagc gcggctacag cttcaccacc acggccgagc gggaaatcgt gcgtgacatt      720

aaggagaagc tgtgctacgt cgccctggac ttcgagcaag agatggccac ggctgcttcc      780

agctcctccc tggagaagag ctacgagctg cctgacggcc aggtcatcac cattggcaat      840

gagcggttcc gctgccctga ggcactcttc cagccttcct tcctgggcat ggagtcctgt      900

ggcatccacg aaactacctt caactccatc atgaagtgtg acgtggacat ccgcaaagac      960

ctgtacgcca acacagtgct gtctggcggc accaccatgt accctggcat tgccgacagg     1020

atgcagaagg agatcactgc cctggcaccc agcacaatga agatcaagat cattgctcct     1080

cctgagcgca agtactccgt gtggatcggc ggctccatcc tggcctcgct gtccaccttc     1140

cagcagatgt ggatcagcaa gcaggagtat gacgagtccg gcccctccat cgtccaccgc     1200

aaatgcttct aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac     1260

ttgcgcagaa aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg     1320

tttttttttt ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc     1380

agtcggttgg agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca     1440

ttgttgtttt tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc     1500

catcctaaaa gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca     1560

cacaggggag gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc     1620

ttcgccttaa tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct     1680

tccccctttt ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg     1740

gtggaggcag ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca     1800

ccttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1852


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  22
tggacttcga gcaagagatg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  23
gaaggaaggc tggaagagtg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  24
cggctgcttc cagctcctcc                                                   20


<210>  25
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  25
gcacccagca caatgaag                                                     18


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  26
cgatccacac ggagtacttg                                                   20


<210>  27
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  27
caagatcatt gctcctcctg agcg                                              24


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  28
ggcatgggtc agaaggatt                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer

<400>  29
agaaggtgtg gtgccagatt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  30
catcgagcac ggcatcgtca                                                   20


<210>  31
<211>  851
<212>  DNA
<213>  Homo sapiens

<400>  31
agaatataac agcactccca aagaactggg tactcaacac tgagcagatc tgttctttga       60

gctaaaaacc atgtgctgta ccaagagttt gctcctggct gctttgatgt cagtgctgct      120

actccacctc tgcggcgaat cagaagcagc aagcaacttt gactgctgtc ttggatacac      180

agaccgtatt cttcatccta aatttattgt gggcttcaca cggcagctgg ccaatgaagg      240

ctgtgacatc aatgctatca tctttcacac aaagaaaaag ttgtctgtgt gcgcaaatcc      300

aaaacagact tgggtgaaat atattgtgcg tctcctcagt aaaaaagtca agaacatgta      360

aaaactgtgg cttttctgga atggaattgg acatagccca agaacagaaa gaaccttgct      420

ggggttggag gtttcacttg cacatcatgg agggtttagt gcttatctaa tttgtgcctc      480

actggacttg tccaattaat gaagttgatt catattgcat catagtttgc tttgtttaag      540

catcacatta aagttaaact gtattttatg ttatttatag ctgtaggttt tctgtgttta      600

gctatttaat actaattttc cataagctat tttggtttag tgcaaagtat aaaattatat      660

ttggggggga ataagattat atggactttc ttgcaagcaa caagctattt tttaaaaaaa      720

actatttaac attcttttgt ttatattgtt ttgtctccta aattgttgta attgcattat      780

aaaataagaa aaatattaat aagacaaata ttgaaaataa agaaacaaaa agttcttctg      840

ttaaaaaaaa a                                                           851


