                         SEQUENCE LISTING

<110>  ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
 
<120>  METHOD FOR IN-VITRO MONITORING OF NEURONAL DISORDERS AND USE 
       THEREOF

<130>  P1323PC00

<150>  CH 01124/10
<151>  2010-07-09

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  3203
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                85                  90                  95      


Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln 
            100                 105                 110         


Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala Glu 
    130                 135                 140                 


Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys Lys Asp 
145                 150                 155                 160 


Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala Gln Ser 
                165                 170                 175     


Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala Met Glu 
            180                 185                 190         


Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg Met Val 
        195                 200                 205             


Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp Ser Asn 
    210                 215                 220                 


Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys Asn Gly 
225                 230                 235                 240 


Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu Leu Ala 
                245                 250                 255     


His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn Leu Leu 
            260                 265                 270         


Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val Gln Glu 
        275                 280                 285             


Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly Asn Phe 
    290                 295                 300                 


Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile Ala Asn 
305                 310                 315                 320 


Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly Ser Ala 
                325                 330                 335     


Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr Ser Trp 
            340                 345                 350         


Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp Glu His 
        355                 360                 365             


Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr Leu Val 
    370                 375                 380                 


Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly Ser Phe 
385                 390                 395                 400 


Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu Gln Leu 
                405                 410                 415     


Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln Asp His 
            420                 425                 430         


Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe Arg Thr 
        435                 440                 445             


Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly Ile Gly 
    450                 455                 460                 


Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg Ser Gly 
465                 470                 475                 480 


Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser Pro Val 
                485                 490                 495     


Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu Glu Ala 
            500                 505                 510         


Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser Ala Leu 
        515                 520                 525             


Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala Ser Ser 
    530                 535                 540                 


Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr Glu Gln 
545                 550                 555                 560 


Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu Ala Ser 
                565                 570                 575     


Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp Ile Leu 
            580                 585                 590         


Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro Ala Met 
        595                 600                 605             


Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp Ser Ser 
    610                 615                 620                 


Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser Asp Ser 
625                 630                 635                 640 


Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly Leu Gln 
                645                 650                 655     


Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile Leu Pro 
            660                 665                 670         


Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu Gln Gln 
        675                 680                 685             


Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser Asp Ser 
    690                 695                 700                 


Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro Gly Asp 
705                 710                 715                 720 


Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln Ser Thr 
                725                 730                 735     


Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu Ser Ala 
            740                 745                 750         


Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp Arg Asp 
        755                 760                 765             


Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly Ala Ala 
    770                 775                 780                 


Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys Val Pro 
785                 790                 795                 800 


Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp Ile Leu 
                805                 810                 815     


Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr Ala Ile 
            820                 825                 830         


Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg Phe His 
        835                 840                 845             


Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn Thr Phe 
    850                 855                 860                 


Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys Asp Glu 
865                 870                 875                 880 


Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn Cys Val 
                885                 890                 895     


Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln Leu Ile 
            900                 905                 910         


Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val Arg Thr 
        915                 920                 925             


Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val Ser Phe 
    930                 935                 940                 


Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His Tyr Thr 
945                 950                 955                 960 


Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val Ile His 
                965                 970                 975     


Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala Ala Ser 
            980                 985                 990         


Leu Ile Arg Leu Val Pro Lys Leu  Phe Tyr Lys Cys Asp  Gln Gly Gln 
        995                 1000                 1005             


Ala Asp  Pro Val Val Ala Val  Ala Arg Asp Gln Ser  Ser Val Tyr 
    1010                 1015                 1020             


Leu Lys  Leu Leu Met His Glu  Thr Gln Pro Pro Ser  His Phe Ser 
    1025                 1030                 1035             


Val Ser  Thr Ile Thr Arg Ile  Tyr Arg Gly Tyr Asn  Leu Leu Pro 
    1040                 1045                 1050             


Ser Ile  Thr Asp Val Thr Met  Glu Asn Asn Leu Ser  Arg Val Ile 
    1055                 1060                 1065             


Ala Ala  Val Ser His Glu Leu  Ile Thr Ser Thr Thr  Arg Ala Leu 
    1070                 1075                 1080             


Thr Phe  Gly Cys Cys Glu Ala  Leu Cys Leu Leu Ser  Thr Ala Phe 
    1085                 1090                 1095             


Pro Val  Cys Ile Trp Ser Leu  Gly Trp His Cys Gly  Val Pro Pro 
    1100                 1105                 1110             


Leu Ser  Ala Ser Asp Glu Ser  Arg Lys Ser Cys Thr  Val Gly Met 
    1115                 1120                 1125             


Ala Thr  Met Ile Leu Thr Leu  Leu Ser Ser Ala Trp  Phe Pro Leu 
    1130                 1135                 1140             


Asp Leu  Ser Ala His Gln Asp  Ala Leu Ile Leu Ala  Gly Asn Leu 
    1145                 1150                 1155             


Leu Ala  Ala Ser Ala Pro Lys  Ser Leu Arg Ser Ser  Trp Ala Ser 
    1160                 1165                 1170             


Glu Glu  Glu Ala Asn Pro Ala  Ala Thr Lys Gln Glu  Glu Val Trp 
    1175                 1180                 1185             


Pro Ala  Leu Gly Asp Arg Ala  Leu Val Pro Met Val  Glu Gln Leu 
    1190                 1195                 1200             


Phe Ser  His Leu Leu Lys Val  Ile Asn Ile Cys Ala  His Val Leu 
    1205                 1210                 1215             


Asp Asp  Val Ala Pro Gly Pro  Ala Ile Lys Ala Ala  Leu Pro Ser 
    1220                 1225                 1230             


Leu Thr  Asn Pro Pro Ser Leu  Ser Pro Ile Arg Arg  Lys Gly Lys 
    1235                 1240                 1245             


Glu Lys  Glu Pro Gly Glu Gln  Ala Ser Val Pro Leu  Ser Pro Lys 
    1250                 1255                 1260             


Lys Gly  Ser Glu Ala Ser Ala  Ala Ser Arg Gln Ser  Asp Thr Ser 
    1265                 1270                 1275             


Gly Pro  Val Thr Thr Ser Lys  Ser Ser Ser Leu Gly  Ser Phe Tyr 
    1280                 1285                 1290             


His Leu  Pro Ser Tyr Leu Lys  Leu His Asp Val Leu  Lys Ala Thr 
    1295                 1300                 1305             


His Ala  Asn Tyr Lys Val Thr  Leu Asp Leu Gln Asn  Ser Thr Glu 
    1310                 1315                 1320             


Lys Phe  Gly Gly Phe Leu Arg  Ser Ala Leu Asp Val  Leu Ser Gln 
    1325                 1330                 1335             


Ile Leu  Glu Leu Ala Thr Leu  Gln Asp Ile Gly Lys  Cys Val Glu 
    1340                 1345                 1350             


Glu Ile  Leu Gly Tyr Leu Lys  Ser Cys Phe Ser Arg  Glu Pro Met 
    1355                 1360                 1365             


Met Ala  Thr Val Cys Val Gln  Gln Leu Leu Lys Thr  Leu Phe Gly 
    1370                 1375                 1380             


Thr Asn  Leu Ala Ser Gln Phe  Asp Gly Leu Ser Ser  Asn Pro Ser 
    1385                 1390                 1395             


Lys Ser  Gln Gly Arg Ala Gln  Arg Leu Gly Ser Ser  Ser Val Arg 
    1400                 1405                 1410             


Pro Gly  Leu Tyr His Tyr Cys  Phe Met Ala Pro Tyr  Thr His Phe 
    1415                 1420                 1425             


Thr Gln  Ala Leu Ala Asp Ala  Ser Leu Arg Asn Met  Val Gln Ala 
    1430                 1435                 1440             


Glu Gln  Glu Asn Asp Thr Ser  Gly Trp Phe Asp Val  Leu Gln Lys 
    1445                 1450                 1455             


Val Ser  Thr Gln Leu Lys Thr  Asn Leu Thr Ser Val  Thr Lys Asn 
    1460                 1465                 1470             


Arg Ala  Asp Lys Asn Ala Ile  His Asn His Ile Arg  Leu Phe Glu 
    1475                 1480                 1485             


Pro Leu  Val Ile Lys Ala Leu  Lys Gln Tyr Thr Thr  Thr Thr Cys 
    1490                 1495                 1500             


Val Gln  Leu Gln Lys Gln Val  Leu Asp Leu Leu Ala  Gln Leu Val 
    1505                 1510                 1515             


Gln Leu  Arg Val Asn Tyr Cys  Leu Leu Asp Ser Asp  Gln Val Phe 
    1520                 1525                 1530             


Ile Gly  Phe Val Leu Lys Gln  Phe Glu Tyr Ile Glu  Val Gly Gln 
    1535                 1540                 1545             


Phe Arg  Glu Ser Glu Ala Ile  Ile Pro Asn Ile Phe  Phe Phe Leu 
    1550                 1555                 1560             


Val Leu  Leu Ser Tyr Glu Arg  Tyr His Ser Lys Gln  Ile Ile Gly 
    1565                 1570                 1575             


Ile Pro  Lys Ile Ile Gln Leu  Cys Asp Gly Ile Met  Ala Ser Gly 
    1580                 1585                 1590             


Arg Lys  Ala Val Thr His Ala  Ile Pro Ala Leu Gln  Pro Ile Val 
    1595                 1600                 1605             


His Asp  Leu Phe Val Leu Arg  Gly Thr Asn Lys Ala  Asp Ala Gly 
    1610                 1615                 1620             


Lys Glu  Leu Glu Thr Gln Lys  Glu Val Val Val Ser  Met Leu Leu 
    1625                 1630                 1635             


Arg Leu  Ile Gln Tyr His Gln  Val Leu Glu Met Phe  Ile Leu Val 
    1640                 1645                 1650             


Leu Gln  Gln Cys His Lys Glu  Asn Glu Asp Lys Trp  Lys Arg Leu 
    1655                 1660                 1665             


Ser Arg  Gln Ile Ala Asp Ile  Ile Leu Pro Met Leu  Ala Lys Gln 
    1670                 1675                 1680             


Gln Met  His Ile Asp Ser His  Glu Ala Leu Gly Val  Leu Asn Thr 
    1685                 1690                 1695             


Leu Phe  Glu Ile Leu Ala Pro  Ser Ser Leu Arg Pro  Val Asp Met 
    1700                 1705                 1710             


Leu Leu  Arg Ser Met Phe Val  Thr Pro Asn Thr Met  Ala Ser Val 
    1715                 1720                 1725             


Ser Thr  Val Gln Leu Trp Ile  Ser Gly Ile Leu Ala  Ile Leu Arg 
    1730                 1735                 1740             


Val Leu  Ile Ser Gln Ser Thr  Glu Asp Ile Val Leu  Ser Arg Ile 
    1745                 1750                 1755             


Gln Glu  Leu Ser Phe Ser Pro  Tyr Leu Ile Ser Cys  Thr Val Ile 
    1760                 1765                 1770             


Asn Arg  Leu Arg Asp Gly Asp  Ser Thr Ser Thr Leu  Glu Glu His 
    1775                 1780                 1785             


Ser Glu  Gly Lys Gln Ile Lys  Asn Leu Pro Glu Glu  Thr Phe Ser 
    1790                 1795                 1800             


Arg Phe  Leu Leu Gln Leu Val  Gly Ile Leu Leu Glu  Asp Ile Val 
    1805                 1810                 1815             


Thr Lys  Gln Leu Lys Val Glu  Met Ser Glu Gln Gln  His Thr Phe 
    1820                 1825                 1830             


Tyr Cys  Gln Glu Leu Gly Thr  Leu Leu Met Cys Leu  Ile His Ile 
    1835                 1840                 1845             


Phe Lys  Ser Gly Met Phe Arg  Arg Ile Thr Ala Ala  Ala Thr Arg 
    1850                 1855                 1860             


Leu Phe  Arg Ser Asp Gly Cys  Gly Gly Ser Phe Tyr  Thr Leu Asp 
    1865                 1870                 1875             


Ser Leu  Asn Leu Arg Ala Arg  Ser Met Ile Thr Thr  His Pro Ala 
    1880                 1885                 1890             


Leu Val  Leu Leu Trp Cys Gln  Ile Leu Leu Leu Val  Asn His Thr 
    1895                 1900                 1905             


Asp Tyr  Arg Trp Trp Ala Glu  Val Gln Gln Thr Pro  Lys Arg His 
    1910                 1915                 1920             


Ser Leu  Ser Ser Thr Lys Leu  Leu Ser Pro Gln Met  Ser Gly Glu 
    1925                 1930                 1935             


Glu Glu  Asp Ser Asp Leu Ala  Ala Lys Leu Gly Met  Cys Asn Arg 
    1940                 1945                 1950             


Glu Ile  Val Arg Arg Gly Ala  Leu Ile Leu Phe Cys  Asp Tyr Val 
    1955                 1960                 1965             


Cys Gln  Asn Leu His Asp Ser  Glu His Leu Thr Trp  Leu Ile Val 
    1970                 1975                 1980             


Asn His  Ile Gln Asp Leu Ile  Ser Leu Ser His Glu  Pro Pro Val 
    1985                 1990                 1995             


Gln Asp  Phe Ile Ser Ala Val  His Arg Asn Ser Ala  Ala Ser Gly 
    2000                 2005                 2010             


Leu Phe  Ile Gln Ala Ile Gln  Ser Arg Cys Glu Asn  Leu Ser Thr 
    2015                 2020                 2025             


Pro Thr  Met Leu Lys Lys Thr  Leu Gln Cys Leu Glu  Gly Ile His 
    2030                 2035                 2040             


Leu Ser  Gln Ser Gly Ala Val  Leu Thr Leu Tyr Val  Asp Arg Leu 
    2045                 2050                 2055             


Leu Cys  Thr Pro Phe Arg Val  Leu Ala Arg Met Val  Asp Ile Leu 
    2060                 2065                 2070             


Ala Cys  Arg Arg Val Glu Met  Leu Leu Ala Ala Asn  Leu Gln Ser 
    2075                 2080                 2085             


Ser Met  Ala Gln Leu Pro Met  Glu Glu Leu Asn Arg  Ile Gln Glu 
    2090                 2095                 2100             


Tyr Leu  Gln Ser Ser Gly Leu  Ala Gln Arg His Gln  Arg Leu Tyr 
    2105                 2110                 2115             


Ser Leu  Leu Asp Arg Phe Arg  Leu Ser Thr Met Gln  Asp Ser Leu 
    2120                 2125                 2130             


Ser Pro  Ser Pro Pro Val Ser  Ser His Pro Leu Asp  Gly Asp Gly 
    2135                 2140                 2145             


His Val  Ser Leu Glu Thr Val  Ser Pro Asp Lys Asp  Trp Tyr Val 
    2150                 2155                 2160             


His Leu  Val Lys Ser Gln Cys  Trp Thr Arg Ser Asp  Ser Ala Leu 
    2165                 2170                 2175             


Leu Glu  Gly Ala Glu Leu Val  Asn Arg Ile Pro Ala  Glu Asp Met 
    2180                 2185                 2190             


Asn Ala  Phe Met Met Asn Ser  Glu Phe Asn Leu Ser  Leu Leu Ala 
    2195                 2200                 2205             


Pro Cys  Leu Ser Leu Gly Met  Ser Glu Ile Ser Gly  Gly Gln Lys 
    2210                 2215                 2220             


Ser Ala  Leu Phe Glu Ala Ala  Arg Glu Val Thr Leu  Ala Arg Val 
    2225                 2230                 2235             


Ser Gly  Thr Val Gln Gln Leu  Pro Ala Val His His  Val Phe Gln 
    2240                 2245                 2250             


Pro Glu  Leu Pro Ala Glu Pro  Ala Ala Tyr Trp Ser  Lys Leu Asn 
    2255                 2260                 2265             


Asp Leu  Phe Gly Asp Ala Ala  Leu Tyr Gln Ser Leu  Pro Thr Leu 
    2270                 2275                 2280             


Ala Arg  Ala Leu Ala Gln Tyr  Leu Val Val Val Ser  Lys Leu Pro 
    2285                 2290                 2295             


Ser His  Leu His Leu Pro Pro  Glu Lys Glu Lys Asp  Ile Val Lys 
    2300                 2305                 2310             


Phe Val  Val Ala Thr Leu Glu  Ala Leu Ser Trp His  Leu Ile His 
    2315                 2320                 2325             


Glu Gln  Ile Pro Leu Ser Leu  Asp Leu Gln Ala Gly  Leu Asp Cys 
    2330                 2335                 2340             


Cys Cys  Leu Ala Leu Gln Leu  Pro Gly Leu Trp Ser  Val Val Ser 
    2345                 2350                 2355             


Ser Thr  Glu Phe Val Thr His  Ala Cys Ser Leu Ile  Tyr Cys Val 
    2360                 2365                 2370             


His Phe  Ile Leu Glu Ala Val  Ala Val Gln Pro Gly  Glu Gln Leu 
    2375                 2380                 2385             


Leu Ser  Pro Glu Arg Arg Thr  Asn Thr Pro Lys Ala  Ile Ser Glu 
    2390                 2395                 2400             


Glu Glu  Glu Glu Val Asp Pro  Asn Thr Gln Asn Pro  Lys Tyr Ile 
    2405                 2410                 2415             


Thr Ala  Ala Cys Glu Met Val  Ala Glu Met Val Glu  Ser Leu Gln 
    2420                 2425                 2430             


Ser Val  Leu Ala Leu Gly His  Lys Arg Asn Ser Gly  Val Pro Ala 
    2435                 2440                 2445             


Phe Leu  Thr Pro Leu Leu Arg  Asn Ile Ile Ile Ser  Leu Ala Arg 
    2450                 2455                 2460             


Leu Pro  Leu Val Asn Ser Tyr  Thr Arg Val Pro Pro  Leu Val Trp 
    2465                 2470                 2475             


Lys Leu  Gly Trp Ser Pro Lys  Pro Gly Gly Asp Phe  Gly Thr Ala 
    2480                 2485                 2490             


Phe Pro  Glu Ile Pro Val Glu  Phe Leu Gln Glu Lys  Glu Val Phe 
    2495                 2500                 2505             


Lys Glu  Phe Ile Tyr Arg Ile  Asn Thr Leu Gly Trp  Thr Ser Arg 
    2510                 2515                 2520             


Thr Gln  Phe Glu Glu Thr Trp  Ala Thr Leu Leu Gly  Val Leu Val 
    2525                 2530                 2535             


Thr Gln  Pro Leu Val Met Glu  Gln Glu Glu Ser Pro  Pro Glu Glu 
    2540                 2545                 2550             


Asp Thr  Glu Arg Thr Gln Ile  Asn Val Leu Ala Val  Gln Ala Ile 
    2555                 2560                 2565             


Thr Ser  Leu Val Leu Ser Ala  Met Thr Val Pro Val  Ala Gly Asn 
    2570                 2575                 2580             


Pro Ala  Val Ser Cys Leu Glu  Gln Gln Pro Arg Asn  Lys Pro Leu 
    2585                 2590                 2595             


Lys Ala  Leu Asp Thr Arg Phe  Gly Arg Lys Leu Ser  Ile Ile Arg 
    2600                 2605                 2610             


Gly Ile  Val Glu Gln Glu Ile  Gln Ala Met Val Ser  Lys Arg Glu 
    2615                 2620                 2625             


Asn Ile  Ala Thr His His Leu  Tyr Gln Ala Trp Asp  Pro Val Pro 
    2630                 2635                 2640             


Ser Leu  Ser Pro Ala Thr Thr  Gly Ala Leu Ile Ser  His Glu Lys 
    2645                 2650                 2655             


Leu Leu  Leu Gln Ile Asn Pro  Glu Arg Glu Leu Gly  Ser Met Ser 
    2660                 2665                 2670             


Tyr Lys  Leu Gly Gln Val Ser  Ile His Ser Val Trp  Leu Gly Asn 
    2675                 2680                 2685             


Ser Ile  Thr Pro Leu Arg Glu  Glu Glu Trp Asp Glu  Glu Glu Glu 
    2690                 2695                 2700             


Glu Glu  Ala Asp Ala Pro Ala  Pro Ser Ser Pro Pro  Thr Ser Pro 
    2705                 2710                 2715             


Val Asn  Ser Arg Lys His Arg  Ala Gly Val Asp Ile  His Ser Cys 
    2720                 2725                 2730             


Ser Gln  Phe Leu Leu Glu Leu  Tyr Ser Arg Trp Ile  Leu Pro Ser 
    2735                 2740                 2745             


Ser Ser  Ala Arg Arg Thr Pro  Ala Ile Leu Ile Ser  Glu Val Val 
    2750                 2755                 2760             


Arg Ser  Leu Leu Val Val Ser  Asp Leu Phe Thr Glu  Arg Asn Gln 
    2765                 2770                 2775             


Phe Glu  Leu Met Tyr Val Thr  Leu Thr Glu Leu Arg  Arg Val His 
    2780                 2785                 2790             


Pro Ser  Glu Asp Glu Ile Leu  Ala Gln Tyr Leu Val  Pro Ala Thr 
    2795                 2800                 2805             


Cys Lys  Ala Ala Ala Val Leu  Gly Met Asp Lys Ala  Val Ala Glu 
    2810                 2815                 2820             


Pro Val  Ser Arg Leu Leu Glu  Ser Thr Leu Arg Ser  Ser His Leu 
    2825                 2830                 2835             


Pro Ser  Arg Val Gly Ala Leu  His Gly Val Leu Tyr  Val Leu Glu 
    2840                 2845                 2850             


Cys Asp  Leu Leu Asp Asp Thr  Ala Lys Gln Leu Ile  Pro Val Ile 
    2855                 2860                 2865             


Ser Asp  Tyr Leu Leu Ser Asn  Leu Lys Gly Ile Ala  His Cys Val 
    2870                 2875                 2880             


Asn Ile  His Ser Gln Gln His  Val Leu Val Met Cys  Ala Thr Ala 
    2885                 2890                 2895             


Phe Tyr  Leu Ile Glu Asn Tyr  Pro Leu Asp Val Gly  Pro Glu Phe 
    2900                 2905                 2910             


Ser Ala  Ser Ile Ile Gln Met  Cys Gly Val Met Leu  Ser Gly Ser 
    2915                 2920                 2925             


Glu Glu  Ser Thr Pro Ser Ile  Ile Tyr His Cys Ala  Leu Arg Gly 
    2930                 2935                 2940             


Leu Glu  Arg Leu Leu Leu Ser  Glu Gln Leu Ser Arg  Leu Asp Ala 
    2945                 2950                 2955             


Glu Ser  Leu Val Lys Leu Ser  Val Asp Arg Val Asn  Val His Ser 
    2960                 2965                 2970             


Pro His  Arg Ala Met Ala Ala  Leu Gly Leu Met Leu  Thr Cys Met 
    2975                 2980                 2985             


Tyr Thr  Gly Lys Glu Lys Val  Ser Pro Gly Arg Thr  Ser Asp Pro 
    2990                 2995                 3000             


Asn Pro  Ala Ala Pro Asp Ser  Glu Ser Val Ile Val  Ala Met Glu 
    3005                 3010                 3015             


Arg Val  Ser Val Leu Phe Asp  Arg Ile Arg Lys Gly  Phe Pro Cys 
    3020                 3025                 3030             


Glu Ala  Arg Val Val Ala Arg  Ile Leu Pro Gln Phe  Leu Asp Asp 
    3035                 3040                 3045             


Phe Phe  Pro Pro Gln Asp Ile  Met Asn Lys Val Ile  Gly Glu Phe 
    3050                 3055                 3060             


Leu Ser  Asn Gln Gln Pro Tyr  Pro Gln Phe Met Ala  Thr Val Val 
    3065                 3070                 3075             


Tyr Lys  Val Phe Gln Thr Leu  His Ser Thr Gly Gln  Ser Ser Met 
    3080                 3085                 3090             


Val Arg  Asp Trp Val Met Leu  Ser Leu Ser Asn Phe  Thr Gln Arg 
    3095                 3100                 3105             


Ala Pro  Val Ala Met Ala Thr  Trp Ser Leu Ser Cys  Phe Phe Val 
    3110                 3115                 3120             


Ser Ala  Ser Thr Ser Pro Trp  Val Ala Ala Ile Leu  Pro His Val 
    3125                 3130                 3135             


Ile Ser  Arg Met Gly Lys Leu  Glu Gln Val Asp Val  Asn Leu Phe 
    3140                 3145                 3150             


Cys Leu  Val Ala Thr Asp Phe  Tyr Arg His Gln Ile  Glu Glu Glu 
    3155                 3160                 3165             


Leu Asp  Arg Arg Ala Phe Gln  Ser Val Leu Glu Val  Val Ala Ala 
    3170                 3175                 3180             


Pro Gly  Ser Pro Tyr His Arg  Leu Leu Thr Cys Leu  Arg Asn Val 
    3185                 3190                 3195             


His Lys  Val Thr Thr 
    3200             


<210>  2
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Htt171-82Q coupled with linking sequences, myc tag and His tag 
       sequences


<220>
<221>  MISC_FEATURE
<222>  (236)..(245)
<223>  Myc-Tag

<220>
<221>  MISC_FEATURE
<222>  (251)..(256)
<223>  HIS-Tag

<400>  2

Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                85                  90                  95      


Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gln Leu 
            100                 105                 110         


Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln Pro Gln Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val Ala Glu Glu 
    130                 135                 140                 


Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys Lys Asp Arg 
145                 150                 155                 160 


Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala Gln Ser Val 
                165                 170                 175     


Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala Met Glu Leu 
            180                 185                 190         


Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg Met Val Ala 
        195                 200                 205             


Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp Ser Asn Leu 
    210                 215                 220                 


Pro Arg Leu Gln Leu Glu Ser Arg Gly Pro Phe Glu Gln Lys Leu Ile 
225                 230                 235                 240 


Ser Glu Glu Asp Leu Asn Met His Thr Gly His His His His His His 
                245                 250                 255     


<210>  3
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  4
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser 
        115                 120                 125             


Gly Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly 
    130                 135                 140                 


Leu Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro 
145                 150                 155                 160 


Glu Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu 
                165                 170                 175     


Asp Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu 
            180                 185                 190         


Leu Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly 
        195                 200                 205             


Lys Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val 
    210                 215                 220                 


Asp Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala 
225                 230                 235                 240 


Gln Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile 
                245                 250                 255     


Pro Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu 
            260                 265                 270         


Ser Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser 
        275                 280                 285             


Val Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His 
    290                 295                 300                 


Val Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu 
305                 310                 315                 320 


His Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu 
                325                 330                 335     


Ala Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro 
            340                 345                 350         


Glu Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val 
        355                 360                 365             


Ser Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp 
    370                 375                 380                 


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser 
385                 390                 395                 400 


Ala Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys Leu Pro Thr 
                405                 410                 415     


Pro Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys 
            420                 425                 430         


Pro Glu Pro Pro Ser Ser Pro Lys His Val Ser Ser Val Thr Ser Arg 
        435                 440                 445             


Thr Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly 
    450                 455                 460                 


Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys 
465                 470                 475                 480 


Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro 
                485                 490                 495     


Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser 
            500                 505                 510         


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
        515                 520                 525             


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
    530                 535                 540                 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
545                 550                 555                 560 


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
                565                 570                 575     


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            580                 585                 590         


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
        595                 600                 605             


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
    610                 615                 620                 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
625                 630                 635                 640 


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
                645                 650                 655     


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
            660                 665                 670         


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
        675                 680                 685             


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
    690                 695                 700                 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
705                 710                 715                 720 


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
                725                 730                 735     


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
            740                 745                 750         


Leu Ala Lys Gln Gly Leu 
        755             


<210>  5
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Glu Leu Pro Ala Pro Leu Ser Tyr Phe Gln Asn Ala Gln Met 
1               5                   10                  15      


Ser Glu Asp Asn His Leu Ser Asn Thr Val Arg Ser Gln Asn Asp Asn 
            20                  25                  30          


Arg Glu Arg Gln Glu His Asn Asp Arg Arg Ser Leu Gly His Pro Glu 
        35                  40                  45              


Pro Leu Ser Asn Gly Arg Pro Gln Gly Asn Ser Arg Gln Val Val Glu 
    50                  55                  60                  


Gln Asp Glu Glu Glu Asp Glu Glu Leu Thr Leu Lys Tyr Gly Ala Lys 
65                  70                  75                  80  


His Val Ile Met Leu Phe Val Pro Val Thr Leu Cys Met Val Val Val 
                85                  90                  95      


Val Ala Thr Ile Lys Ser Val Ser Phe Tyr Thr Arg Lys Asp Gly Gln 
            100                 105                 110         


Leu Ile Tyr Thr Pro Phe Thr Glu Asp Thr Glu Thr Val Gly Gln Arg 
        115                 120                 125             


Ala Leu His Ser Ile Leu Asn Ala Ala Ile Met Ile Ser Val Ile Val 
    130                 135                 140                 


Val Met Thr Ile Leu Leu Val Val Leu Tyr Lys Tyr Arg Cys Tyr Lys 
145                 150                 155                 160 


Val Ile His Ala Trp Leu Ile Ile Ser Ser Leu Leu Leu Leu Phe Phe 
                165                 170                 175     


Phe Ser Phe Ile Tyr Leu Gly Glu Val Phe Lys Thr Tyr Asn Val Ala 
            180                 185                 190         


Val Asp Tyr Ile Thr Val Ala Leu Leu Ile Trp Asn Phe Gly Val Val 
        195                 200                 205             


Gly Met Ile Ser Ile His Trp Lys Gly Pro Leu Arg Leu Gln Gln Ala 
    210                 215                 220                 


Tyr Leu Ile Met Ile Ser Ala Leu Met Ala Leu Val Phe Ile Lys Tyr 
225                 230                 235                 240 


Leu Pro Glu Trp Thr Ala Trp Leu Ile Leu Ala Val Ile Ser Val Tyr 
                245                 250                 255     


Asp Leu Val Ala Val Leu Cys Pro Lys Gly Pro Leu Arg Met Leu Val 
            260                 265                 270         


Glu Thr Ala Gln Glu Arg Asn Glu Thr Leu Phe Pro Ala Leu Ile Tyr 
        275                 280                 285             


Ser Ser Thr Met Val Trp Leu Val Asn Met Ala Glu Gly Asp Pro Glu 
    290                 295                 300                 


Ala Gln Arg Arg Val Ser Lys Asn Ser Lys Tyr Asn Ala Glu Ser Thr 
305                 310                 315                 320 


Glu Arg Glu Ser Gln Asp Thr Val Ala Glu Asn Asp Asp Gly Gly Phe 
                325                 330                 335     


Ser Glu Glu Trp Glu Ala Gln Arg Asp Ser His Leu Gly Pro His Arg 
            340                 345                 350         


Ser Thr Pro Glu Ser Arg Ala Ala Val Gln Glu Leu Ser Ser Ser Ile 
        355                 360                 365             


Leu Ala Gly Glu Asp Pro Glu Glu Arg Gly Val Lys Leu Gly Leu Gly 
    370                 375                 380                 


Asp Phe Ile Phe Tyr Ser Val Leu Val Gly Lys Ala Ser Ala Thr Ala 
385                 390                 395                 400 


Ser Gly Asp Trp Asn Thr Thr Ile Ala Cys Phe Val Ala Ile Leu Ile 
                405                 410                 415     


Gly Leu Cys Leu Thr Leu Leu Leu Leu Ala Ile Phe Lys Lys Ala Leu 
            420                 425                 430         


Pro Ala Leu Pro Ile Ser Ile Thr Phe Gly Leu Val Phe Tyr Phe Ala 
        435                 440                 445             


Thr Asp Tyr Leu Val Gln Pro Phe Met Asp Gln Leu Ala Phe His Gln 
    450                 455                 460                 


Phe Tyr Ile 
465         


<210>  6
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Trp Thr Leu Val Ser Trp Val Asp Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210>  7
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  8
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
            100                 105                 110         


<210>  9
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Val Ala Glu Lys Thr Lys Glu Gln 
        35                  40                  45              


Val Thr Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala 
    50                  55                  60                  


Gln Lys Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe 
65                  70                  75                  80  


Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu 
                85                  90                  95      


Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu 
            100                 105                 110         


Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
        115                 120                 125     


<210>  10
<211>  2527
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ser Gly Ser Cys Gln Gly Cys Glu Glu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Lys Leu Ile Val Arg Leu Asn Asn Val Gln Glu Gly Lys Gln Ile 
            20                  25                  30          


Glu Thr Leu Val Gln Ile Leu Glu Asp Leu Leu Val Phe Thr Tyr Ser 
        35                  40                  45              


Glu Arg Ala Ser Lys Leu Phe Gln Gly Lys Asn Ile His Val Pro Leu 
    50                  55                  60                  


Leu Ile Val Leu Asp Ser Tyr Met Arg Val Ala Ser Val Gln Gln Val 
65                  70                  75                  80  


Gly Trp Ser Leu Leu Cys Lys Leu Ile Glu Val Cys Pro Gly Thr Met 
                85                  90                  95      


Gln Ser Leu Met Gly Pro Gln Asp Val Gly Asn Asp Trp Glu Val Leu 
            100                 105                 110         


Gly Val His Gln Leu Ile Leu Lys Met Leu Thr Val His Asn Ala Ser 
        115                 120                 125             


Val Asn Leu Ser Val Ile Gly Leu Lys Thr Leu Asp Leu Leu Leu Thr 
    130                 135                 140                 


Ser Gly Lys Ile Thr Leu Leu Ile Leu Asp Glu Glu Ser Asp Ile Phe 
145                 150                 155                 160 


Met Leu Ile Phe Asp Ala Met His Ser Phe Pro Ala Asn Asp Glu Val 
                165                 170                 175     


Gln Lys Leu Gly Cys Lys Ala Leu His Val Leu Phe Glu Arg Val Ser 
            180                 185                 190         


Glu Glu Gln Leu Thr Glu Phe Val Glu Asn Lys Asp Tyr Met Ile Leu 
        195                 200                 205             


Leu Ser Ala Leu Thr Asn Phe Lys Asp Glu Glu Glu Ile Val Leu His 
    210                 215                 220                 


Val Leu His Cys Leu His Ser Leu Ala Ile Pro Cys Asn Asn Val Glu 
225                 230                 235                 240 


Val Leu Met Ser Gly Asn Val Arg Cys Tyr Asn Ile Val Val Glu Ala 
                245                 250                 255     


Met Lys Ala Phe Pro Met Ser Glu Arg Ile Gln Glu Val Ser Cys Cys 
            260                 265                 270         


Leu Leu His Arg Leu Thr Leu Gly Asn Phe Phe Asn Ile Leu Val Leu 
        275                 280                 285             


Asn Glu Val His Glu Phe Val Val Lys Ala Val Gln Gln Tyr Pro Glu 
    290                 295                 300                 


Asn Ala Ala Leu Gln Ile Ser Ala Leu Ser Cys Leu Ala Leu Leu Thr 
305                 310                 315                 320 


Glu Thr Ile Phe Leu Asn Gln Asp Leu Glu Glu Lys Asn Glu Asn Gln 
                325                 330                 335     


Glu Asn Asp Asp Glu Gly Glu Glu Asp Lys Leu Phe Trp Leu Glu Ala 
            340                 345                 350         


Cys Tyr Lys Ala Leu Thr Trp His Arg Lys Asn Lys His Val Gln Glu 
        355                 360                 365             


Ala Ala Cys Trp Ala Leu Asn Asn Leu Leu Met Tyr Gln Asn Ser Leu 
    370                 375                 380                 


His Glu Lys Ile Gly Asp Glu Asp Gly His Phe Pro Ala His Arg Glu 
385                 390                 395                 400 


Val Met Leu Ser Met Leu Met His Ser Ser Ser Lys Glu Val Phe Gln 
                405                 410                 415     


Ala Ser Ala Asn Ala Leu Ser Thr Leu Leu Glu Gln Asn Val Asn Phe 
            420                 425                 430         


Arg Lys Ile Leu Leu Ser Lys Gly Ile His Leu Asn Val Leu Glu Leu 
        435                 440                 445             


Met Gln Lys His Ile His Ser Pro Glu Val Ala Glu Ser Gly Cys Lys 
    450                 455                 460                 


Met Leu Asn His Leu Phe Glu Gly Ser Asn Thr Ser Leu Asp Ile Met 
465                 470                 475                 480 


Ala Ala Val Val Pro Lys Ile Leu Thr Val Met Lys Arg His Glu Thr 
                485                 490                 495     


Ser Leu Pro Val Gln Leu Glu Ala Leu Arg Ala Ile Leu His Phe Ile 
            500                 505                 510         


Val Pro Gly Met Pro Glu Glu Ser Arg Glu Asp Thr Glu Phe His His 
        515                 520                 525             


Lys Leu Asn Met Val Lys Lys Gln Cys Phe Lys Asn Asp Ile His Lys 
    530                 535                 540                 


Leu Val Leu Ala Ala Leu Asn Arg Phe Ile Gly Asn Pro Gly Ile Gln 
545                 550                 555                 560 


Lys Cys Gly Leu Lys Val Ile Ser Ser Ile Val His Phe Pro Asp Ala 
                565                 570                 575     


Leu Glu Met Leu Ser Leu Glu Gly Ala Met Asp Ser Val Leu His Thr 
            580                 585                 590         


Leu Gln Met Tyr Pro Asp Asp Gln Glu Ile Gln Cys Leu Gly Leu Ser 
        595                 600                 605             


Leu Ile Gly Tyr Leu Ile Thr Lys Lys Asn Val Phe Ile Gly Thr Gly 
    610                 615                 620                 


His Leu Leu Ala Lys Ile Leu Val Ser Ser Leu Tyr Arg Phe Lys Asp 
625                 630                 635                 640 


Val Ala Glu Ile Gln Thr Lys Gly Phe Gln Thr Ile Leu Ala Ile Leu 
                645                 650                 655     


Lys Leu Ser Ala Ser Phe Ser Lys Leu Leu Val His His Ser Phe Asp 
            660                 665                 670         


Leu Val Ile Phe His Gln Met Ser Ser Asn Ile Met Glu Gln Lys Asp 
        675                 680                 685             


Gln Gln Phe Leu Asn Leu Cys Cys Lys Cys Phe Ala Lys Val Ala Met 
    690                 695                 700                 


Asp Asp Tyr Leu Lys Asn Val Met Leu Glu Arg Ala Cys Asp Gln Asn 
705                 710                 715                 720 


Asn Ser Ile Met Val Glu Cys Leu Leu Leu Leu Gly Ala Asp Ala Asn 
                725                 730                 735     


Gln Ala Lys Glu Gly Ser Ser Leu Ile Cys Gln Val Cys Glu Lys Glu 
            740                 745                 750         


Ser Ser Pro Lys Leu Val Glu Leu Leu Leu Asn Ser Gly Ser Arg Glu 
        755                 760                 765             


Gln Asp Val Arg Lys Ala Leu Thr Ile Ser Ile Gly Lys Gly Asp Ser 
    770                 775                 780                 


Gln Ile Ile Ser Leu Leu Leu Arg Arg Leu Ala Leu Asp Val Ala Asn 
785                 790                 795                 800 


Asn Ser Ile Cys Leu Gly Gly Phe Cys Ile Gly Lys Val Glu Pro Ser 
                805                 810                 815     


Trp Leu Gly Pro Leu Phe Pro Asp Lys Thr Ser Asn Leu Arg Lys Gln 
            820                 825                 830         


Thr Asn Ile Ala Ser Thr Leu Ala Arg Met Val Ile Arg Tyr Gln Met 
        835                 840                 845             


Lys Ser Ala Val Glu Glu Gly Thr Ala Ser Gly Ser Asp Gly Asn Phe 
    850                 855                 860                 


Ser Glu Asp Val Leu Ser Lys Phe Asp Glu Trp Thr Phe Ile Pro Asp 
865                 870                 875                 880 


Ser Ser Met Asp Ser Val Phe Ala Gln Ser Asp Asp Leu Asp Ser Glu 
                885                 890                 895     


Gly Ser Glu Gly Ser Phe Leu Val Lys Lys Lys Ser Asn Ser Ile Ser 
            900                 905                 910         


Val Gly Glu Phe Tyr Arg Asp Ala Val Leu Gln Arg Cys Ser Pro Asn 
        915                 920                 925             


Leu Gln Arg His Ser Asn Ser Leu Gly Pro Ile Phe Asp His Glu Asp 
    930                 935                 940                 


Leu Leu Lys Arg Lys Arg Lys Ile Leu Ser Ser Asp Asp Ser Leu Arg 
945                 950                 955                 960 


Ser Ser Lys Leu Gln Ser His Met Arg His Ser Asp Ser Ile Ser Ser 
                965                 970                 975     


Leu Ala Ser Glu Arg Glu Tyr Ile Thr Ser Leu Asp Leu Ser Ala Asn 
            980                 985                 990         


Glu Leu Arg Asp Ile Asp Ala Leu  Ser Gln Lys Cys Cys  Ile Ser Val 
        995                 1000                 1005             


His Leu  Glu His Leu Glu Lys  Leu Glu Leu His Gln  Asn Ala Leu 
    1010                 1015                 1020             


Thr Ser  Phe Pro Gln Gln Leu  Cys Glu Thr Leu Lys  Ser Leu Thr 
    1025                 1030                 1035             


His Leu  Asp Leu His Ser Asn  Lys Phe Thr Ser Phe  Pro Ser Tyr 
    1040                 1045                 1050             


Leu Leu  Lys Met Ser Cys Ile  Ala Asn Leu Asp Val  Ser Arg Asn 
    1055                 1060                 1065             


Asp Ile  Gly Pro Ser Val Val  Leu Asp Pro Thr Val  Lys Cys Pro 
    1070                 1075                 1080             


Thr Leu  Lys Gln Phe Asn Leu  Ser Tyr Asn Gln Leu  Ser Phe Val 
    1085                 1090                 1095             


Pro Glu  Asn Leu Thr Asp Val  Val Glu Lys Leu Glu  Gln Leu Ile 
    1100                 1105                 1110             


Leu Glu  Gly Asn Lys Ile Ser  Gly Ile Cys Ser Pro  Leu Arg Leu 
    1115                 1120                 1125             


Lys Glu  Leu Lys Ile Leu Asn  Leu Ser Lys Asn His  Ile Ser Ser 
    1130                 1135                 1140             


Leu Ser  Glu Asn Phe Leu Glu  Ala Cys Pro Lys Val  Glu Ser Phe 
    1145                 1150                 1155             


Ser Ala  Arg Met Asn Phe Leu  Ala Ala Met Pro Phe  Leu Pro Pro 
    1160                 1165                 1170             


Ser Met  Thr Ile Leu Lys Leu  Ser Gln Asn Lys Phe  Ser Cys Ile 
    1175                 1180                 1185             


Pro Glu  Ala Ile Leu Asn Leu  Pro His Leu Arg Ser  Leu Asp Met 
    1190                 1195                 1200             


Ser Ser  Asn Asp Ile Gln Tyr  Leu Pro Gly Pro Ala  His Trp Lys 
    1205                 1210                 1215             


Ser Leu  Asn Leu Arg Glu Leu  Leu Phe Ser His Asn  Gln Ile Ser 
    1220                 1225                 1230             


Ile Leu  Asp Leu Ser Glu Lys  Ala Tyr Leu Trp Ser  Arg Val Glu 
    1235                 1240                 1245             


Lys Leu  His Leu Ser His Asn  Lys Leu Lys Glu Ile  Pro Pro Glu 
    1250                 1255                 1260             


Ile Gly  Cys Leu Glu Asn Leu  Thr Ser Leu Asp Val  Ser Tyr Asn 
    1265                 1270                 1275             


Leu Glu  Leu Arg Ser Phe Pro  Asn Glu Met Gly Lys  Leu Ser Lys 
    1280                 1285                 1290             


Ile Trp  Asp Leu Pro Leu Asp  Glu Leu His Leu Asn  Phe Asp Phe 
    1295                 1300                 1305             


Lys His  Ile Gly Cys Lys Ala  Lys Asp Ile Ile Arg  Phe Leu Gln 
    1310                 1315                 1320             


Gln Arg  Leu Lys Lys Ala Val  Pro Tyr Asn Arg Met  Lys Leu Met 
    1325                 1330                 1335             


Ile Val  Gly Asn Thr Gly Ser  Gly Lys Thr Thr Leu  Leu Gln Gln 
    1340                 1345                 1350             


Leu Met  Lys Thr Lys Lys Ser  Asp Leu Gly Met Gln  Ser Ala Thr 
    1355                 1360                 1365             


Val Gly  Ile Asp Val Lys Asp  Trp Pro Ile Gln Ile  Arg Asp Lys 
    1370                 1375                 1380             


Arg Lys  Arg Asp Leu Val Leu  Asn Val Trp Asp Phe  Ala Gly Arg 
    1385                 1390                 1395             


Glu Glu  Phe Tyr Ser Thr His  Pro His Phe Met Thr  Gln Arg Ala 
    1400                 1405                 1410             


Leu Tyr  Leu Ala Val Tyr Asp  Leu Ser Lys Gly Gln  Ala Glu Val 
    1415                 1420                 1425             


Asp Ala  Met Lys Pro Trp Leu  Phe Asn Ile Lys Ala  Arg Ala Ser 
    1430                 1435                 1440             


Ser Ser  Pro Val Ile Leu Val  Gly Thr His Leu Asp  Val Ser Asp 
    1445                 1450                 1455             


Glu Lys  Gln Arg Lys Ala Cys  Met Ser Lys Ile Thr  Lys Glu Leu 
    1460                 1465                 1470             


Leu Asn  Lys Arg Gly Phe Pro  Ala Ile Arg Asp Tyr  His Phe Val 
    1475                 1480                 1485             


Asn Ala  Thr Glu Glu Ser Asp  Ala Leu Ala Lys Leu  Arg Lys Thr 
    1490                 1495                 1500             


Ile Ile  Asn Glu Ser Leu Asn  Phe Lys Ile Arg Asp  Gln Leu Val 
    1505                 1510                 1515             


Val Gly  Gln Leu Ile Pro Asp  Cys Tyr Val Glu Leu  Glu Lys Ile 
    1520                 1525                 1530             


Ile Leu  Ser Glu Arg Lys Asn  Val Pro Ile Glu Phe  Pro Val Ile 
    1535                 1540                 1545             


Asp Arg  Lys Arg Leu Leu Gln  Leu Val Arg Glu Asn  Gln Leu Gln 
    1550                 1555                 1560             


Leu Asp  Glu Asn Glu Leu Pro  His Ala Val His Phe  Leu Asn Glu 
    1565                 1570                 1575             


Ser Gly  Val Leu Leu His Phe  Gln Asp Pro Ala Leu  Gln Leu Ser 
    1580                 1585                 1590             


Asp Leu  Tyr Phe Val Glu Pro  Lys Trp Leu Cys Lys  Ile Met Ala 
    1595                 1600                 1605             


Gln Ile  Leu Thr Val Lys Val  Glu Gly Cys Pro Lys  His Pro Lys 
    1610                 1615                 1620             


Gly Ile  Ile Ser Arg Arg Asp  Val Glu Lys Phe Leu  Ser Lys Lys 
    1625                 1630                 1635             


Arg Lys  Phe Pro Lys Asn Tyr  Met Ser Gln Tyr Phe  Lys Leu Leu 
    1640                 1645                 1650             


Glu Lys  Phe Gln Ile Ala Leu  Pro Ile Gly Glu Glu  Tyr Leu Leu 
    1655                 1660                 1665             


Val Pro  Ser Ser Leu Ser Asp  His Arg Pro Val Ile  Glu Leu Pro 
    1670                 1675                 1680             


His Cys  Glu Asn Ser Glu Ile  Ile Ile Arg Leu Tyr  Glu Met Pro 
    1685                 1690                 1695             


Tyr Phe  Pro Met Gly Phe Trp  Ser Arg Leu Ile Asn  Arg Leu Leu 
    1700                 1705                 1710             


Glu Ile  Ser Pro Tyr Met Leu  Ser Gly Arg Glu Arg  Ala Leu Arg 
    1715                 1720                 1725             


Pro Asn  Arg Met Tyr Trp Arg  Gln Gly Ile Tyr Leu  Asn Trp Ser 
    1730                 1735                 1740             


Pro Glu  Ala Tyr Cys Leu Val  Gly Ser Glu Val Leu  Asp Asn His 
    1745                 1750                 1755             


Pro Glu  Ser Phe Leu Lys Ile  Thr Val Pro Ser Cys  Arg Lys Gly 
    1760                 1765                 1770             


Cys Ile  Leu Leu Gly Gln Val  Val Asp His Ile Asp  Ser Leu Met 
    1775                 1780                 1785             


Glu Glu  Trp Phe Pro Gly Leu  Leu Glu Ile Asp Ile  Cys Gly Glu 
    1790                 1795                 1800             


Gly Glu  Thr Leu Leu Lys Lys  Trp Ala Leu Tyr Ser  Phe Asn Asp 
    1805                 1810                 1815             


Gly Glu  Glu His Gln Lys Ile  Leu Leu Asp Asp Leu  Met Lys Lys 
    1820                 1825                 1830             


Ala Glu  Glu Gly Asp Leu Leu  Val Asn Pro Asp Gln  Pro Arg Leu 
    1835                 1840                 1845             


Thr Ile  Pro Ile Ser Gln Ile  Ala Pro Asp Leu Ile  Leu Ala Asp 
    1850                 1855                 1860             


Leu Pro  Arg Asn Ile Met Leu  Asn Asn Asp Glu Leu  Glu Phe Glu 
    1865                 1870                 1875             


Gln Ala  Pro Glu Phe Leu Leu  Gly Asp Gly Ser Phe  Gly Ser Val 
    1880                 1885                 1890             


Tyr Arg  Ala Ala Tyr Glu Gly  Glu Glu Val Ala Val  Lys Ile Phe 
    1895                 1900                 1905             


Asn Lys  His Thr Ser Leu Arg  Leu Leu Arg Gln Glu  Leu Val Val 
    1910                 1915                 1920             


Leu Cys  His Leu His His Pro  Ser Leu Ile Ser Leu  Leu Ala Ala 
    1925                 1930                 1935             


Gly Ile  Arg Pro Arg Met Leu  Val Met Glu Leu Ala  Ser Lys Gly 
    1940                 1945                 1950             


Ser Leu  Asp Arg Leu Leu Gln  Gln Asp Lys Ala Ser  Leu Thr Arg 
    1955                 1960                 1965             


Thr Leu  Gln His Arg Ile Ala  Leu His Val Ala Asp  Gly Leu Arg 
    1970                 1975                 1980             


Tyr Leu  His Ser Ala Met Ile  Ile Tyr Arg Asp Leu  Lys Pro His 
    1985                 1990                 1995             


Asn Val  Leu Leu Phe Thr Leu  Tyr Pro Asn Ala Ala  Ile Ile Ala 
    2000                 2005                 2010             


Lys Ile  Ala Asp Tyr Gly Ile  Ala Gln Tyr Cys Cys  Arg Met Gly 
    2015                 2020                 2025             


Ile Lys  Thr Ser Glu Gly Thr  Pro Gly Phe Arg Ala  Pro Glu Val 
    2030                 2035                 2040             


Ala Arg  Gly Asn Val Ile Tyr  Asn Gln Gln Ala Asp  Val Tyr Ser 
    2045                 2050                 2055             


Phe Gly  Leu Leu Leu Tyr Asp  Ile Leu Thr Thr Gly  Gly Arg Ile 
    2060                 2065                 2070             


Val Glu  Gly Leu Lys Phe Pro  Asn Glu Phe Asp Glu  Leu Glu Ile 
    2075                 2080                 2085             


Gln Gly  Lys Leu Pro Asp Pro  Val Lys Glu Tyr Gly  Cys Ala Pro 
    2090                 2095                 2100             


Trp Pro  Met Val Glu Lys Leu  Ile Lys Gln Cys Leu  Lys Glu Asn 
    2105                 2110                 2115             


Pro Gln  Glu Arg Pro Thr Ser  Ala Gln Val Phe Asp  Ile Leu Asn 
    2120                 2125                 2130             


Ser Ala  Glu Leu Val Cys Leu  Thr Arg Arg Ile Leu  Leu Pro Lys 
    2135                 2140                 2145             


Asn Val  Ile Val Glu Cys Met  Val Ala Thr His His  Asn Ser Arg 
    2150                 2155                 2160             


Asn Ala  Ser Ile Trp Leu Gly  Cys Gly His Thr Asp  Arg Gly Gln 
    2165                 2170                 2175             


Leu Ser  Phe Leu Asp Leu Asn  Thr Glu Gly Tyr Thr  Ser Glu Glu 
    2180                 2185                 2190             


Val Ala  Asp Ser Arg Ile Leu  Cys Leu Ala Leu Val  His Leu Pro 
    2195                 2200                 2205             


Val Glu  Lys Glu Ser Trp Ile  Val Ser Gly Thr Gln  Ser Gly Thr 
    2210                 2215                 2220             


Leu Leu  Val Ile Asn Thr Glu  Asp Gly Lys Lys Arg  His Thr Leu 
    2225                 2230                 2235             


Glu Lys  Met Thr Asp Ser Val  Thr Cys Leu Tyr Cys  Asn Ser Phe 
    2240                 2245                 2250             


Ser Lys  Gln Ser Lys Gln Lys  Asn Phe Leu Leu Val  Gly Thr Ala 
    2255                 2260                 2265             


Asp Gly  Lys Leu Ala Ile Phe  Glu Asp Lys Thr Val  Lys Leu Lys 
    2270                 2275                 2280             


Gly Ala  Ala Pro Leu Lys Ile  Leu Asn Ile Gly Asn  Val Ser Thr 
    2285                 2290                 2295             


Pro Leu  Met Cys Leu Ser Glu  Ser Thr Asn Ser Thr  Glu Arg Asn 
    2300                 2305                 2310             


Val Met  Trp Gly Gly Cys Gly  Thr Lys Ile Phe Ser  Phe Ser Asn 
    2315                 2320                 2325             


Asp Phe  Thr Ile Gln Lys Leu  Ile Glu Thr Arg Thr  Ser Gln Leu 
    2330                 2335                 2340             


Phe Ser  Tyr Ala Ala Phe Ser  Asp Ser Asn Ile Ile  Thr Val Val 
    2345                 2350                 2355             


Val Asp  Thr Ala Leu Tyr Ile  Ala Lys Gln Asn Ser  Pro Val Val 
    2360                 2365                 2370             


Glu Val  Trp Asp Lys Lys Thr  Glu Lys Leu Cys Gly  Leu Ile Asp 
    2375                 2380                 2385             


Cys Val  His Phe Leu Arg Glu  Val Met Val Lys Glu  Asn Lys Glu 
    2390                 2395                 2400             


Ser Lys  His Lys Met Ser Tyr  Ser Gly Arg Val Lys  Thr Leu Cys 
    2405                 2410                 2415             


Leu Gln  Lys Asn Thr Ala Leu  Trp Ile Gly Thr Gly  Gly Gly His 
    2420                 2425                 2430             


Ile Leu  Leu Leu Asp Leu Ser  Thr Arg Arg Leu Ile  Arg Val Ile 
    2435                 2440                 2445             


Tyr Asn  Phe Cys Asn Ser Val  Arg Val Met Met Thr  Ala Gln Leu 
    2450                 2455                 2460             


Gly Ser  Leu Lys Asn Val Met  Leu Val Leu Gly Tyr  Asn Arg Lys 
    2465                 2470                 2475             


Asn Thr  Glu Gly Thr Gln Lys  Gln Lys Glu Ile Gln  Ser Cys Leu 
    2480                 2485                 2490             


Thr Val  Trp Asp Ile Asn Leu  Pro His Glu Val Gln  Asn Leu Glu 
    2495                 2500                 2505             


Lys His  Ile Glu Val Arg Lys  Glu Leu Ala Glu Lys  Met Arg Arg 
    2510                 2515                 2520             


Thr Ser  Val Glu 
    2525         


<210>  11
<211>  1180
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ala Asp Ser Ser Pro Leu Val Gly Ser Thr Pro Thr Gly Tyr 
1               5                   10                  15      


Gly Thr Leu Thr Ile Gly Thr Ser Ile Asp Pro Leu Ser Ser Ser Val 
            20                  25                  30          


Ser Ser Val Arg Leu Ser Gly Tyr Cys Gly Ser Pro Trp Arg Val Ile 
        35                  40                  45              


Gly Tyr His Val Val Val Trp Met Met Ala Gly Ile Pro Leu Leu Leu 
    50                  55                  60                  


Phe Arg Trp Lys Pro Leu Trp Gly Val Arg Leu Arg Leu Arg Pro Cys 
65                  70                  75                  80  


Asn Leu Ala His Ala Glu Thr Leu Val Ile Glu Ile Arg Asp Lys Glu 
                85                  90                  95      


Asp Ser Ser Trp Gln Leu Phe Thr Val Gln Val Gln Thr Glu Ala Ile 
            100                 105                 110         


Gly Glu Gly Ser Leu Glu Pro Ser Pro Gln Ser Gln Ala Glu Asp Gly 
        115                 120                 125             


Arg Ser Gln Ala Ala Val Gly Ala Val Pro Glu Gly Ala Trp Lys Asp 
    130                 135                 140                 


Thr Ala Gln Leu His Lys Ser Glu Glu Ala Val Ser Val Gly Gln Lys 
145                 150                 155                 160 


Arg Val Leu Arg Tyr Tyr Leu Phe Gln Gly Gln Arg Tyr Ile Trp Ile 
                165                 170                 175     


Glu Thr Gln Gln Ala Phe Tyr Gln Val Ser Leu Leu Asp His Gly Arg 
            180                 185                 190         


Ser Cys Asp Asp Val His Arg Ser Arg His Gly Leu Ser Leu Gln Asp 
        195                 200                 205             


Gln Met Val Arg Lys Ala Ile Tyr Gly Pro Asn Val Ile Ser Ile Pro 
    210                 215                 220                 


Val Lys Ser Tyr Pro Gln Leu Leu Val Asp Glu Ala Leu Asn Pro Tyr 
225                 230                 235                 240 


Tyr Gly Phe Gln Ala Phe Ser Ile Ala Leu Trp Leu Ala Asp His Tyr 
                245                 250                 255     


Tyr Trp Tyr Ala Leu Cys Ile Phe Leu Ile Ser Ser Ile Ser Ile Cys 
            260                 265                 270         


Leu Ser Leu Tyr Lys Thr Arg Lys Gln Ser Gln Thr Leu Arg Asp Met 
        275                 280                 285             


Val Lys Leu Ser Met Arg Val Cys Val Cys Arg Pro Gly Gly Glu Glu 
    290                 295                 300                 


Glu Trp Val Asp Ser Ser Glu Leu Val Pro Gly Asp Cys Leu Val Leu 
305                 310                 315                 320 


Pro Gln Glu Gly Gly Leu Met Pro Cys Asp Ala Ala Leu Val Ala Gly 
                325                 330                 335     


Glu Cys Met Val Asn Glu Ser Ser Leu Thr Gly Glu Ser Ile Pro Val 
            340                 345                 350         


Leu Lys Thr Ala Leu Pro Glu Gly Leu Gly Pro Tyr Cys Ala Glu Thr 
        355                 360                 365             


His Arg Arg His Thr Leu Phe Cys Gly Thr Leu Ile Leu Gln Ala Arg 
    370                 375                 380                 


Ala Tyr Val Gly Pro His Val Leu Ala Val Val Thr Arg Thr Gly Phe 
385                 390                 395                 400 


Cys Thr Ala Lys Gly Gly Leu Val Ser Ser Ile Leu His Pro Arg Pro 
                405                 410                 415     


Ile Asn Phe Lys Phe Tyr Lys His Ser Met Lys Phe Val Ala Ala Leu 
            420                 425                 430         


Ser Val Leu Ala Leu Leu Gly Thr Ile Tyr Ser Ile Phe Ile Leu Tyr 
        435                 440                 445             


Arg Asn Arg Val Pro Leu Asn Glu Ile Val Ile Arg Ala Leu Asp Leu 
    450                 455                 460                 


Val Thr Val Val Val Pro Pro Ala Leu Pro Ala Ala Met Thr Val Cys 
465                 470                 475                 480 


Thr Leu Tyr Ala Gln Ser Arg Leu Arg Arg Gln Gly Ile Phe Cys Ile 
                485                 490                 495     


His Pro Leu Arg Ile Asn Leu Gly Gly Lys Leu Gln Leu Val Cys Phe 
            500                 505                 510         


Asp Lys Thr Gly Thr Leu Thr Glu Asp Gly Leu Asp Val Met Gly Val 
        515                 520                 525             


Val Pro Leu Lys Gly Gln Ala Phe Leu Pro Leu Val Pro Glu Pro Arg 
    530                 535                 540                 


Arg Leu Pro Val Gly Pro Leu Leu Arg Ala Leu Ala Thr Cys His Ala 
545                 550                 555                 560 


Leu Ser Arg Leu Gln Asp Thr Pro Val Gly Asp Pro Met Asp Leu Lys 
                565                 570                 575     


Met Val Glu Ser Thr Gly Trp Val Leu Glu Glu Glu Pro Ala Ala Asp 
            580                 585                 590         


Ser Ala Phe Gly Thr Gln Val Leu Ala Val Met Arg Pro Pro Leu Trp 
        595                 600                 605             


Glu Pro Gln Leu Gln Ala Met Glu Glu Pro Pro Val Pro Val Ser Val 
    610                 615                 620                 


Leu His Arg Phe Pro Phe Ser Ser Ala Leu Gln Arg Met Ser Val Val 
625                 630                 635                 640 


Val Ala Trp Pro Gly Ala Thr Gln Pro Glu Ala Tyr Val Lys Gly Ser 
                645                 650                 655     


Pro Glu Leu Val Ala Gly Leu Cys Asn Pro Glu Thr Val Pro Thr Asp 
            660                 665                 670         


Phe Ala Gln Met Leu Gln Ser Tyr Thr Ala Ala Gly Tyr Arg Val Val 
        675                 680                 685             


Ala Leu Ala Ser Lys Pro Leu Pro Thr Val Pro Ser Leu Glu Ala Ala 
    690                 695                 700                 


Gln Gln Leu Thr Arg Asp Thr Val Glu Gly Asp Leu Ser Leu Leu Gly 
705                 710                 715                 720 


Leu Leu Val Met Arg Asn Leu Leu Lys Pro Gln Thr Thr Pro Val Ile 
                725                 730                 735     


Gln Ala Leu Arg Arg Thr Arg Ile Arg Ala Val Met Val Thr Gly Asp 
            740                 745                 750         


Asn Leu Gln Thr Ala Val Thr Val Ala Arg Gly Cys Gly Met Val Ala 
        755                 760                 765             


Pro Gln Glu His Leu Ile Ile Val His Ala Thr His Pro Glu Arg Gly 
    770                 775                 780                 


Gln Pro Ala Ser Leu Glu Phe Leu Pro Met Glu Ser Pro Thr Ala Val 
785                 790                 795                 800 


Asn Gly Val Lys Asp Pro Asp Gln Ala Ala Ser Tyr Thr Val Glu Pro 
                805                 810                 815     


Asp Pro Arg Ser Arg His Leu Ala Leu Ser Gly Pro Thr Phe Gly Ile 
            820                 825                 830         


Ile Val Lys His Phe Pro Lys Leu Leu Pro Lys Val Leu Val Gln Gly 
        835                 840                 845             


Thr Val Phe Ala Arg Met Ala Pro Glu Gln Lys Thr Glu Leu Val Cys 
    850                 855                 860                 


Glu Leu Gln Lys Leu Gln Tyr Cys Val Gly Met Cys Gly Asp Gly Ala 
865                 870                 875                 880 


Asn Asp Cys Gly Ala Leu Lys Ala Ala Asp Val Gly Ile Ser Leu Ser 
                885                 890                 895     


Gln Ala Glu Ala Ser Val Val Ser Pro Phe Thr Ser Ser Met Ala Ser 
            900                 905                 910         


Ile Glu Cys Val Pro Met Val Ile Arg Glu Gly Arg Cys Ser Leu Asp 
        915                 920                 925             


Thr Ser Phe Ser Val Phe Lys Tyr Met Ala Leu Tyr Ser Leu Thr Gln 
    930                 935                 940                 


Phe Ile Ser Val Leu Ile Leu Tyr Thr Ile Asn Thr Asn Leu Gly Asp 
945                 950                 955                 960 


Leu Gln Phe Leu Ala Ile Asp Leu Val Ile Thr Thr Thr Val Ala Val 
                965                 970                 975     


Leu Met Ser Arg Thr Gly Pro Ala Leu Val Leu Gly Arg Val Arg Pro 
            980                 985                 990         


Pro Gly Ala Leu Leu Ser Val Pro  Val Leu Ser Ser Leu  Leu Leu Gln 
        995                 1000                 1005             


Met Val  Leu Val Thr Gly Val  Gln Leu Gly Gly Tyr  Phe Leu Thr 
    1010                 1015                 1020             


Leu Ala  Gln Pro Trp Phe Val  Pro Leu Asn Arg Thr  Val Ala Ala 
    1025                 1030                 1035             


Pro Asp  Asn Leu Pro Asn Tyr  Glu Asn Thr Val Val  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Phe Gln Tyr Leu Ile  Leu Ala Ala Ala Val  Ser Lys Gly 
    1055                 1060                 1065             


Ala Pro  Phe Arg Arg Pro Leu  Tyr Thr Asn Val Pro  Phe Leu Val 
    1070                 1075                 1080             


Ala Leu  Ala Leu Leu Ser Ser  Val Leu Val Gly Leu  Val Leu Val 
    1085                 1090                 1095             


Pro Gly  Leu Leu Gln Gly Pro  Leu Ala Leu Arg Asn  Ile Thr Asp 
    1100                 1105                 1110             


Thr Gly  Phe Lys Leu Leu Leu  Leu Gly Leu Val Thr  Leu Asn Phe 
    1115                 1120                 1125             


Val Gly  Ala Phe Met Leu Glu  Ser Val Leu Asp Gln  Cys Leu Pro 
    1130                 1135                 1140             


Ala Cys  Leu Arg Arg Leu Arg  Pro Lys Arg Ala Ser  Lys Lys Arg 
    1145                 1150                 1155             


Phe Lys  Gln Leu Glu Arg Glu  Leu Ala Glu Gln Pro  Trp Pro Pro 
    1160                 1165                 1170             


Leu Pro  Ala Gly Pro Leu Arg  
    1175                 1180 


<210>  12
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Ala Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210>  13
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Gln Ser Lys Arg His Val Tyr Ser Arg Thr Pro Ser Gly Ser 
1               5                   10                  15      


Arg Met Ser Ala Glu Ala Ser Ala Arg Pro Leu Arg Val Gly Ser Arg 
            20                  25                  30          


Val Glu Val Ile Gly Lys Gly His Arg Gly Thr Val Ala Tyr Val Gly 
        35                  40                  45              


Ala Thr Leu Phe Ala Thr Gly Lys Trp Val Gly Val Ile Leu Asp Glu 
    50                  55                  60                  


Ala Lys Gly Lys Asn Asp Gly Thr Val Gln Gly Arg Lys Tyr Phe Thr 
65                  70                  75                  80  


Cys Asp Glu Gly His Gly Ile Phe Val Arg Gln Ser Gln Ile Gln Val 
                85                  90                  95      


Phe Glu Asp Gly Ala Asp Thr Thr Ser Pro Glu Thr Pro Asp Ser Ser 
            100                 105                 110         


Ala Ser Lys Val Leu Lys Arg Glu Gly Thr Asp Thr Thr Ala Lys Thr 
        115                 120                 125             


Ser Lys Leu Arg Gly Leu Lys Pro Lys Lys Ala Pro Thr Ala Arg Lys 
    130                 135                 140                 


Thr Thr Thr Arg Arg Pro Lys Pro Thr Arg Pro Ala Ser Thr Gly Val 
145                 150                 155                 160 


Ala Gly Ala Ser Ser Ser Leu Gly Pro Ser Gly Ser Ala Ser Ala Gly 
                165                 170                 175     


Glu Leu Ser Ser Ser Glu Pro Ser Thr Pro Ala Gln Thr Pro Leu Ala 
            180                 185                 190         


Ala Pro Ile Ile Pro Thr Pro Val Leu Thr Ser Pro Gly Ala Val Pro 
        195                 200                 205             


Pro Leu Pro Ser Pro Ser Lys Glu Glu Glu Gly Leu Arg Ala Gln Val 
    210                 215                 220                 


Arg Asp Leu Glu Glu Lys Leu Glu Thr Leu Arg Leu Lys Arg Ala Glu 
225                 230                 235                 240 


Asp Lys Ala Lys Leu Lys Glu Leu Glu Lys His Lys Ile Gln Leu Glu 
                245                 250                 255     


Gln Val Gln Glu Trp Lys Ser Lys Met Gln Glu Gln Gln Ala Asp Leu 
            260                 265                 270         


Gln Arg Arg Leu Lys Glu Ala Arg Lys Glu Ala Lys Glu Ala Leu Glu 
        275                 280                 285             


Ala Lys Glu Arg Tyr Met Glu Glu Met Ala Asp Thr Ala Asp Ala Ile 
    290                 295                 300                 


Glu Met Ala Thr Leu Asp Lys Glu Met Ala Glu Glu Arg Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Gln Glu Val Glu Ala Leu Lys Glu Arg Val Asp Glu Leu Thr 
                325                 330                 335     


Thr Asp Leu Glu Ile Leu Lys Ala Glu Ile Glu Glu Lys Gly Ser Asp 
            340                 345                 350         


Gly Ala Ala Ser Ser Tyr Gln Leu Lys Gln Leu Glu Glu Gln Asn Ala 
        355                 360                 365             


Arg Leu Lys Asp Ala Leu Val Arg Met Arg Asp Leu Ser Ser Ser Glu 
    370                 375                 380                 


Lys Gln Glu His Val Lys Leu Gln Lys Leu Met Glu Lys Lys Asn Gln 
385                 390                 395                 400 


Glu Leu Glu Val Val Arg Gln Gln Arg Glu Arg Leu Gln Glu Glu Leu 
                405                 410                 415     


Ser Gln Ala Glu Ser Thr Ile Asp Glu Leu Lys Glu Gln Val Asp Ala 
            420                 425                 430         


Ala Leu Gly Ala Glu Glu Met Val Glu Met Leu Thr Asp Arg Asn Leu 
        435                 440                 445             


Asn Leu Glu Glu Lys Val Arg Glu Leu Arg Glu Thr Val Gly Asp Leu 
    450                 455                 460                 


Glu Ala Met Asn Glu Met Asn Asp Glu Leu Gln Glu Asn Ala Arg Glu 
465                 470                 475                 480 


Thr Glu Leu Glu Leu Arg Glu Gln Leu Asp Met Ala Gly Ala Arg Val 
                485                 490                 495     


Arg Glu Ala Gln Lys Arg Val Glu Ala Ala Gln Glu Thr Val Ala Asp 
            500                 505                 510         


Tyr Gln Gln Thr Ile Lys Lys Tyr Arg Gln Leu Thr Ala His Leu Gln 
        515                 520                 525             


Asp Val Asn Arg Glu Leu Thr Asn Gln Gln Glu Ala Ser Val Glu Arg 
    530                 535                 540                 


Gln Gln Gln Pro Pro Pro Glu Thr Phe Asp Phe Lys Ile Lys Phe Ala 
545                 550                 555                 560 


Glu Thr Lys Ala His Ala Lys Ala Ile Glu Thr Glu Leu Arg Gln Met 
                565                 570                 575     


Glu Val Ala Gln Ala Asn Arg His Met Ser Leu Leu Thr Ala Phe Met 
            580                 585                 590         


Pro Asp Ser Phe Leu Arg Pro Gly Gly Asp His Asp Cys Val Leu Val 
        595                 600                 605             


Leu Leu Leu Met Pro Arg Leu Ile Cys Lys Ala Glu Leu Ile Arg Lys 
    610                 615                 620                 


Gln Ala Gln Glu Lys Phe Glu Leu Ser Glu Asn Cys Ser Glu Arg Pro 
625                 630                 635                 640 


Gly Leu Arg Gly Ala Ala Gly Glu Gln Leu Ser Phe Ala Ala Gly Leu 
                645                 650                 655     


Val Tyr Ser Leu Ser Leu Leu Gln Ala Thr Leu His Arg Tyr Glu His 
            660                 665                 670         


Ala Leu Ser Gln Cys Ser Val Asp Val Tyr Lys Lys Val Gly Ser Leu 
        675                 680                 685             


Tyr Pro Glu Met Ser Ala His Glu Arg Ser Leu Asp Phe Leu Ile Glu 
    690                 695                 700                 


Leu Leu His Lys Asp Gln Leu Asp Glu Thr Val Asn Val Glu Pro Leu 
705                 710                 715                 720 


Thr Lys Ala Ile Lys Tyr Tyr Gln His Leu Tyr Ser Ile His Leu Ala 
                725                 730                 735     


Glu Gln Pro Glu Asp Cys Thr Met Gln Leu Ala Asp His Ile Lys Phe 
            740                 745                 750         


Thr Gln Ser Ala Leu Asp Cys Met Ser Val Glu Val Gly Arg Leu Arg 
        755                 760                 765             


Ala Phe Leu Gln Gly Gly Gln Glu Ala Thr Asp Ile Ala Leu Leu Leu 
    770                 775                 780                 


Arg Asp Leu Glu Thr Ser Cys Ser Asp Ile Arg Gln Phe Cys Lys Lys 
785                 790                 795                 800 


Ile Arg Arg Arg Met Pro Gly Thr Asp Ala Pro Gly Ile Pro Ala Ala 
                805                 810                 815     


Leu Ala Phe Gly Pro Gln Val Ser Asp Thr Leu Leu Asp Cys Arg Lys 
            820                 825                 830         


His Leu Thr Trp Val Val Ala Val Leu Gln Glu Val Ala Ala Ala Ala 
        835                 840                 845             


Ala Gln Leu Ile Ala Pro Leu Ala Glu Asn Glu Gly Leu Leu Val Ala 
    850                 855                 860                 


Ala Leu Glu Glu Leu Ala Phe Lys Ala Ser Glu Gln Ile Tyr Gly Thr 
865                 870                 875                 880 


Pro Ser Ser Ser Pro Tyr Glu Cys Leu Arg Gln Ser Cys Asn Ile Leu 
                885                 890                 895     


Ile Ser Thr Met Asn Lys Leu Ala Thr Ala Met Gln Glu Gly Glu Tyr 
            900                 905                 910         


Asp Ala Glu Arg Pro Pro Ser Lys Pro Pro Pro Val Glu Leu Arg Ala 
        915                 920                 925             


Ala Ala Leu Arg Ala Glu Ile Thr Asp Ala Glu Gly Leu Gly Leu Lys 
    930                 935                 940                 


Leu Glu Asp Arg Glu Thr Val Ile Lys Glu Leu Lys Lys Ser Leu Lys 
945                 950                 955                 960 


Ile Lys Gly Glu Glu Leu Ser Glu Ala Asn Val Arg Leu Ser Leu Leu 
                965                 970                 975     


Glu Lys Lys Leu Asp Ser Ala Ala Lys Asp Ala Asp Glu Arg Ile Glu 
            980                 985                 990         


Lys Val Gln Thr Arg Leu Glu Glu  Thr Gln Ala Leu Leu  Arg Lys Lys 
        995                 1000                 1005             


Glu Lys  Glu Phe Glu Glu Thr  Met Asp Ala Leu Gln  Ala Asp Ile 
    1010                 1015                 1020             


Asp Gln  Leu Glu Ala Glu Lys  Ala Glu Leu Lys Gln  Arg Leu Asn 
    1025                 1030                 1035             


Ser Gln  Ser Lys Arg Thr Ile  Glu Gly Leu Arg Gly  Pro Pro Pro 
    1040                 1045                 1050             


Ser Gly  Ile Ala Thr Leu Val  Ser Gly Ile Ala Gly  Glu Glu Gln 
    1055                 1060                 1065             


Gln Arg  Gly Ala Ile Pro Gly  Gln Ala Pro Gly Ser  Val Pro Gly 
    1070                 1075                 1080             


Pro Gly  Leu Val Lys Asp Ser  Pro Leu Leu Leu Gln  Gln Ile Ser 
    1085                 1090                 1095             


Ala Met  Arg Leu His Ile Ser  Gln Leu Gln His Glu  Asn Ser Ile 
    1100                 1105                 1110             


Leu Lys  Gly Ala Gln Met Lys  Ala Ser Leu Ala Ser  Leu Pro Pro 
    1115                 1120                 1125             


Leu His  Val Ala Lys Leu Ser  His Glu Gly Pro Gly  Ser Glu Leu 
    1130                 1135                 1140             


Pro Ala  Gly Ala Leu Tyr Arg  Lys Thr Ser Gln Leu  Leu Glu Thr 
    1145                 1150                 1155             


Leu Asn  Gln Leu Ser Thr His  Thr His Val Val Asp  Ile Thr Arg 
    1160                 1165                 1170             


Thr Ser  Pro Ala Ala Lys Ser  Pro Ser Ala Gln Leu  Met Glu Gln 
    1175                 1180                 1185             


Val Ala  Gln Leu Lys Ser Leu  Ser Asp Thr Val Glu  Lys Leu Lys 
    1190                 1195                 1200             


Asp Glu  Val Leu Lys Glu Thr  Val Ser Gln Arg Pro  Gly Ala Thr 
    1205                 1210                 1215             


Val Pro  Thr Asp Phe Ala Thr  Phe Pro Ser Ser Ala  Phe Leu Arg 
    1220                 1225                 1230             


Ala Lys  Glu Glu Gln Gln Asp  Asp Thr Val Tyr Met  Gly Lys Val 
    1235                 1240                 1245             


Thr Phe  Ser Cys Ala Ala Gly  Phe Gly Gln Arg His  Arg Leu Val 
    1250                 1255                 1260             


Leu Thr  Gln Glu Gln Leu His  Gln Leu His Ser Arg  Leu Ile Ser 
    1265                 1270                 1275             


<210>  14
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Htt171-82Q + linking sequences + myc tag + 6X 
       His tag


<220>
<221>  misc_feature
<222>  (706)..(735)
<223>  Myc-Tag

<220>
<221>  misc_feature
<222>  (751)..(768)
<223>  HIS-Tag

<400>  14
atggcgaccc tggaaaagct gatgaaggcc ttcgagtccc tcaagtcctt ccagcagcag       60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      120

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      180

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag      240

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcaacagccg      300

ccaccgccgc cgccgccgcc gccgcctcct cagcttcctc agccgccgcc gcaggcacag      360

ccgctgctgc ctcagccgca gccgcccccg ccgccgcccc cgccgccacc cggcccggct      420

gtggctgagg agccgctgca ccgaccaaag aaagaacttt cagctaccaa gaaagaccgt      480

gtgaatcatt gtctgacaat atgtgaaaac atagtggcac agtctgtcag aaattctcca      540

gaatttcaga aacttctggg catcgctatg gaactttttc tgctgtgcag tgatgacgca      600

gagtcagatg tcaggatggt ggctgacgaa tgcctcaaca aagttatcaa agctttgatg      660

gattctaatc ttccaaggtt acagctcgag tctagagggc ccttcgaaca aaaactcatc      720

tcagaagagg atctgaatat gcataccggt catcatcacc atcaccattg a               771


<210>  15
<211>  9373
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the first 171 amino acids of mutated htt 
       (htt171-82Q)


<220>
<221>  LTR
<222>  (1)..(634)
<223>  5'-LTR

<220>
<221>  misc_feature
<222>  (2055)..(2366)
<223>  TRE

<220>
<221>  misc_feature
<222>  (2368)..(2487)
<223>  Pmin CMV

<220>
<221>  TATA_signal
<222>  (2390)..(2397)

<220>
<221>  misc_feature
<222>  (2545)..(3051)
<223>  Htt171-18Q

<220>
<221>  misc_feature
<222>  (3067)..(3096)
<223>  Myc-Tag

<220>
<221>  misc_feature
<222>  (3112)..(3129)
<223>  His-Tag

<220>
<221>  misc_feature
<222>  (3224)..(3831)
<223>  WPRE

<220>
<221>  misc_feature
<222>  (3916)..(3930)
<223>  cPPT

<220>
<221>  LTR
<222>  (3933)..(4166)
<223>  3'-LTR

<220>
<221>  misc_feature
<222>  (8356)..(9205)
<223>  SV40 polyA

<400>  15
tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca      180

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag      300

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacctgaaag      660

cgaaagggaa accagagctc tctcgacgca ggactcggct tgctgaagcg cgcgcacggc      720

aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg gaggctagaa      780

ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat cgcgatggga      840

aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc      900

aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg      960

tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc     1020

attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac     1080

caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca ccgcacagca     1140

agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat     1200

tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga     1260

gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct     1320

tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac     1380

aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac     1440

agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg     1500

tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca     1560

tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattt     1620

ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca agcttaatac     1680

actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa ttattggaat     1740

tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg tggtatataa     1800

aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt gctgtacttt     1860

ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc cacctcccaa     1920

ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag agagacagag     1980

acagatccat tcgattagtg aacggatctc gacggtatcg atcacgagac tagcctcgac     2040

catcgatggt cgagtttacc actccctatc agtgatagag aaaagtgaaa gtcgagttta     2100

ccactcccta tcagtgatag agaaaagtga aagtcgagtt taccactccc tatcagtgat     2160

agagaaaagt gaaagtcgag tttaccactc cctatcagtg atagagaaaa gtgaaagtcg     2220

agtttaccac tccctatcag tgatagagaa aagtgaaagt cgagtttacc actccctatc     2280

agtgatagag aaaagtgaaa gtcgagttta ccactcccta tcagtgatag agaaaagtga     2340

aagtcgagct cggtacccgg gtcgaggtag gcgtgtacgg tgggaggcct atataagcag     2400

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca     2460

tagaagacac cgggaccgat ccagcctccg cggccccgaa ttcgagctcg gtacccgggg     2520

atcaattctc tagagatatc gtcgatggcg accctggaaa agctgatgaa ggccttcgag     2580

tccctcaagt ccttccagca gcagcagcag cagcagcagc agcagcagca gcagcagcag     2640

cagcaacagc cgccaccgcc gccgccgccg ccgccgccgc cgccgcctcc tcagcttcct     2700

cagccgccgc cgcaggcaca gccgctgctg cctcagccgc agccgccccc gccgccgccc     2760

ccgccgccac ccggcccggc tgtggctgag gagccgctgc accgaccaaa gaaagaactt     2820

tcagctacca agaaagaccg tgtgaatcat tgtctgacaa tatgtgaaaa catagtggca     2880

cagtctgtca gaaattctcc agaatttcag aaacttctgg gcatcgctat ggaacttttt     2940

ctgctgtgca gtgatgacgc agagtcagat gtcaggatgg tggctgacga atgcctcaac     3000

aaagttatca aagctttgat ggattctaat cttccaaggt tacagctcga gtctagaggg     3060

cccttcgaac aaaaactcat ctcagaagag gatctgaata tgcataccgg tcatcatcac     3120

catcaccatt gagttttcga gtgagagaag attttcagcc tgatacagat taaaatcgtc     3180

gagggaattg atcctctaga gtcgacctgc aggcatgcaa gctaattccg ataatcaacc     3240

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     3300

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     3360

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     3420

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     3480

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     3540

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     3600

tgacaattcc gtggtgttgt cggggaagct gacgtccttt ccatggctgc tcgcctgtgt     3660

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     3720

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     3780

ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgggaat tagcttgtta     3840

acatcgatgg aattcgagct cggtaccttt aaaaccaatg acttacaagg cagctgtaaa     3900

tcttagccac tttttaaaag aaaagggggg actggaaggg ctaattcact cccaacgaaa     3960

acaaaatctg ctttttgctt gtactgggtc tctctggtta gaccaaatct gagcctggga     4020

gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct     4080

tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcaaaccctt     4140

ttagtcagtg tggaaaatct ctagcagcat ctagaattaa ttccgtgtat tctatagtgt     4200

cacctaaatc gtatgtgtat gatacataag gttatgtatt aattgtagcc gcgttctaac     4260

gacaatatgt acaagcctaa ttgtgtagca tctggcttac tgaagcagac cctatcatct     4320

ctctcgtaaa ctgccgtcag agtcggtttg gttggacgaa ccttctgagt ttctggtaac     4380

gccgtcccgc acccggaaat ggtcagcgaa ccaatcagca gggtcatcgc tagccagatc     4440

ctctacgccg gacgcatcgt ggccggcatc accggcgcca caggtgcggt tgctggcgcc     4500

tatatcgccg acatcaccga tggggaagat cgggctcgcc acttcgggct catgagcgct     4560

tgtttcggcg tgggtatggt ggcaggcccc gtggccgggg gactgttggg cgccatctcc     4620

ttgcatgcac cattccttgc ggcggcggtg ctcaacggcc tcaacctact actgggctgc     4680

ttcctaatgc aggagtcgca taagggagag cgtcgatatg gtgcactctc agtacaatct     4740

gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct     4800

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     4860

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga     4920

tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca     4980

cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata     5040

tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga     5100

gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc     5160

ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg     5220

cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc     5280

ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat     5340

cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact     5400

tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat     5460

tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga     5520

tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc     5580

ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga     5640

tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag     5700

cttcccggca acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc     5760

gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt     5820

ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct     5880

acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg     5940

cctcactgat taagcattgg taactgtcag accaagttta ctcatatata ctttagattg     6000

atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca     6060

tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga     6120

tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa     6180

aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga     6240

aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt     6300

taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt     6360

taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat     6420

agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct     6480

tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca     6540

cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag     6600

agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc     6660

gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga     6720

aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca     6780

tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag     6840

ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg     6900

aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     6960

gtggaatgtg tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat     7020

gcaaagcatg catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc     7080

aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac     7140

tccgcccatc ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact     7200

aatttttttt atttatgcag aggccgaggc cgcctcggcc tctgagctat tccagaagta     7260

gtgaggaggc ttttttggag gcctaggctt ttgcaaaaag cttggacaca agacaggctt     7320

gcgagatatg tttgagaata ccactttatc ccgcgtcagg gagaggcagt gcgtaaaaag     7380

acgcggactc atgtgaaata ctggttttta gtgcgccaga tctctataat ctcgcgcaac     7440

ctattttccc ctcgaacact ttttaagccg tagataaaca ggctgggaca cttcacatga     7500

gcgaaaaata catcgtcacc tgggacatgt tgcagatcca tgcacgtaaa ctcgcaagcc     7560

gactgatgcc ttctgaacaa tggaaaggca ttattgccgt aagccgtggc ggtctgtacc     7620

gggtgcgtta ctggcgcgtg aactgggtat tcgtcatgtc gataccgttt gtatttccag     7680

ctacgatcac gacaaccagc gcgagcttaa agtgctgaaa cgcgcagaag gcgatggcga     7740

aggcttcatc gttattgatg acctggtgga taccggtggt actgcggttg cgattcgtga     7800

aatgtatcca aaagcgcact ttgtcaccat cttcgcaaaa ccggctggtc gtccgctggt     7860

tgatgactat gttgttgata tcccgcaaga tacctggatt gaacagccgt gggatatggg     7920

cgtcgtattc gtcccgccaa tctccggtcg ctaatctttt caacgcctgg cactgccggg     7980

cgttgttctt tttaacttca ggcgggttac aatagtttcc agtaagtatt ctggaggctg     8040

catccatgac acaggcaaac ctgagcgaaa ccctgttcaa accccgcttt aaacatcctg     8100

aaacctcgac gctagtccgc cgctttaatc acggcgcaca accgcctgtg cagtcggccc     8160

ttgatggtaa aaccatccct cactggtatc gcatgattaa ccgtctgatg tggatctggc     8220

gcggcattga cccacgcgaa atcctcgacg tccaggcacg tattgtgatg agcgatgccg     8280

aacgtaccga cgatgattta tacgatacgg tgattggcta ccgtggcggc aactggattt     8340

atgagtgggc cccggatctt tgtgaaggaa ccttacttct gtggtgtgac ataattggac     8400

aaactaccta cagagattta aagctctaag gtaaatataa aatttttaag tgtataatgt     8460

gttaaactac tgattctaat tgtttgtgta ttttagattc caacctatgg aactgatgaa     8520

tgggagcagt ggtggaatgc ctttaatgag gaaaacctgt tttgctcaga agaaatgcca     8580

tctagtgatg atgaggctac tgctgactct caacattcta ctcctccaaa aaagaagaga     8640

aaggtagaag accccaagga ctttccttca gaattgctaa gttttttgag tcatgctgtg     8700

tttagtaata gaactcttgc ttgctttgct atttacacca caaaggaaaa agctgcactg     8760

ctatacaaga aaattatgga aaaatattct gtaaccttta taagtaggca taacagttat     8820

aatcataaca tactgttttt tcttactcca cacaggcata gagtgtctgc tattaataac     8880

tatgctcaaa aattgtgtac ctttagcttt ttaatttgta aaggggttaa taaggaatat     8940

ttgatgtata gtgccttgac tagagatcat aatcagccat accacatttg tagagctttt     9000

acttgcttta aaaaacctcc cacacctccc cctgaacctg aaacataaaa tgaatgcaat     9060

tgttgttgtt aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac     9120

aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat     9180

caatgtatct tatcatgtgt ggatcaactg gataactcaa gctaaccaaa atcatcccaa     9240

acttcccacc ccatacccta ttaccactgc caaattacct gtggtttcat ttactctaaa     9300

cctgtgattc ctctgaatta ttttcatttt aaagaaattg tatttgttaa atatgtacta     9360

caaacttagt agt                                                        9373


<210>  16
<211>  9558
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmid encoding the first 171 amino acids of wild-type htt 
       (htt171-18Q)


<220>
<221>  LTR
<222>  (1)..(634)
<223>  5'-LTR

<220>
<221>  misc_feature
<222>  (2055)..(2366)
<223>  TRE

<220>
<221>  misc_feature
<222>  (2368)..(2487)
<223>  Pmin CMV

<220>
<221>  TATA_signal
<222>  (2390)..(2397)

<220>
<221>  misc_feature
<222>  (2547)..(3236)
<223>  Htt171-82Q

<220>
<221>  misc_feature
<222>  (3252)..(3281)
<223>  Myc-Tag

<220>
<221>  misc_feature
<222>  (3297)..(3314)
<223>  HIS-Tag

<220>
<221>  misc_feature
<222>  (3409)..(4016)
<223>  WPRE

<220>
<221>  misc_feature
<222>  (4101)..(4115)
<223>  cPPT

<220>
<221>  LTR
<222>  (4118)..(4351)
<223>  3'-LTR

<400>  16
tggaagggct aattcactcc caaagaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tagcagaact acacaccagg gccaggggtc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagcc agataaggta gaagaggcca      180

ataaaggaga gaacaccagc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt gttagagtgg aggtttgaca gccgcctagc atttcatcac gtggcccgag      300

agctgcatcc ggagtacttc aagaactgct gatatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt actgggtctc tctggttaga ccagatctga      480

gcctgggagc tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct      540

tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc      600

agaccctttt agtcagtgtg gaaaatctct agcagtggcg cccgaacagg gacctgaaag      660

cgaaagggaa accagagctc tctcgacgca ggactcggct tgctgaagcg cgcgcacggc      720

aagaggcgag gggcggcgac tggtgagtac gccaaaaatt ttgactagcg gaggctagaa      780

ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat cgcgatggga      840

aaaaattcgg ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc      900

aagcagggag ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg      960

tagacaaata ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc     1020

attatataat acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac     1080

caaggaagct ttagacaaga tagaggaaga gcaaaacaaa agtaagacca ccgcacagca     1140

agcggccgct gatcttcaga cctggaggag gagatatgag ggacaattgg agaagtgaat     1200

tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc aaggcaaaga     1260

gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc cttgggttct     1320

tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta caggccagac     1380

aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt gaggcgcaac     1440

agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga atcctggctg     1500

tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct ggaaaactca     1560

tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg gaacagattt     1620

ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca agcttaatac     1680

actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa ttattggaat     1740

tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg tggtatataa     1800

aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt gctgtacttt     1860

ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc cacctcccaa     1920

ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag agagacagag     1980

acagatccat tcgattagtg aacggatctc gacggtatcg atcacgagac tagcctcgac     2040

catcgatggt cgagtttacc actccctatc agtgatagag aaaagtgaaa gtcgagttta     2100

ccactcccta tcagtgatag agaaaagtga aagtcgagtt taccactccc tatcagtgat     2160

agagaaaagt gaaagtcgag tttaccactc cctatcagtg atagagaaaa gtgaaagtcg     2220

agtttaccac tccctatcag tgatagagaa aagtgaaagt cgagtttacc actccctatc     2280

agtgatagag aaaagtgaaa gtcgagttta ccactcccta tcagtgatag agaaaagtga     2340

aagtcgagct cggtacccgg gtcgaggtag gcgtgtacgg tgggaggcct atataagcag     2400

agctcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca     2460

tagaagacac cgggaccgat ccagcctccg cggccccgaa ttcgagctcg gtacccgggg     2520

atcaattctc tagagatatc gtcgacatgg cgaccctgga aaagctgatg aaggccttcg     2580

agtccctcaa gtccttccag cagcagcagc agcagcagca gcagcagcag cagcagcagc     2640

agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc     2700

agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc     2760

agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc     2820

agcagcagca gcagcagcaa cagccgccac cgccgccgcc gccgccgccg cctcctcagc     2880

ttcctcagcc gccgccgcag gcacagccgc tgctgcctca gccgcagccg cccccgccgc     2940

cgcccccgcc gccacccggc ccggctgtgg ctgaggagcc gctgcaccga ccaaagaaag     3000

aactttcagc taccaagaaa gaccgtgtga atcattgtct gacaatatgt gaaaacatag     3060

tggcacagtc tgtcagaaat tctccagaat ttcagaaact tctgggcatc gctatggaac     3120

tttttctgct gtgcagtgat gacgcagagt cagatgtcag gatggtggct gacgaatgcc     3180

tcaacaaagt tatcaaagct ttgatggatt ctaatcttcc aaggttacag ctcgagtcta     3240

gagggccctt cgaacaaaaa ctcatctcag aagaggatct gaatatgcat accggtcatc     3300

atcaccatca ccattgagtt ttcgagtgag agaagatttt cagcctgata cagattaaaa     3360

tcgtcgaggg aattgatcct ctagagtcga cctgcaggca tgcaagctaa ttccgataat     3420

caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta tgttgctcct     3480

tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc ttcccgtatg     3540

gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga ggagttgtgg     3600

cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac ccccactggt     3660

tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc cctccctatt     3720

gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg     3780

ggcactgaca attccgtggt gttgtcgggg aagctgacgt cctttccatg gctgctcgcc     3840

tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc ggccctcaat     3900

ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc gcgtcttcgc     3960

cttcgccctc agacgagtcg gatctccctt tgggccgcct ccccgcatcg ggaattagct     4020

tgttaacatc gatggaattc gagctcggta cctttaaaac caatgactta caaggcagct     4080

gtaaatctta gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa     4140

cgaaaacaaa atctgctttt tgcttgtact gggtctctct ggttagacca aatctgagcc     4200

tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga     4260

gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaaa     4320

cccttttagt cagtgtggaa aatctctagc agcatctaga attaattccg tgtattctat     4380

agtgtcacct aaatcgtatg tgtatgatac ataaggttat gtattaattg tagccgcgtt     4440

ctaacgacaa tatgtacaag cctaattgtg tagcatctgg cttactgaag cagaccctat     4500

catctctctc gtaaactgcc gtcagagtcg gtttggttgg acgaaccttc tgagtttctg     4560

gtaacgccgt cccgcacccg gaaatggtca gcgaaccaat cagcagggtc atcgctagcc     4620

agatcctcta cgccggacgc atcgtggccg gcatcaccgg cgccacaggt gcggttgctg     4680

gcgcctatat cgccgacatc accgatgggg aagatcgggc tcgccacttc gggctcatga     4740

gcgcttgttt cggcgtgggt atggtggcag gccccgtggc cgggggactg ttgggcgcca     4800

tctccttgca tgcaccattc cttgcggcgg cggtgctcaa cggcctcaac ctactactgg     4860

gctgcttcct aatgcaggag tcgcataagg gagagcgtcg atatggtgca ctctcagtac     4920

aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac ccgctgacgc     4980

gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga ccgtctccgg     5040

gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac gaaagggcct     5100

cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg     5160

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc     5220

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     5280

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg     5340

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt     5400

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt     5460

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt     5520

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa     5580

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag     5640

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac     5700

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac     5760

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac     5820

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac     5880

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact     5940

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg     6000

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt     6060

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat     6120

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta     6180

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa     6240

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     6300

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     6360

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     6420

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc     6480

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     6540

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     6600

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     6660

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     6720

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     6780

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     6840

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     6900

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     6960

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga     7020

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga     7080

agcggaagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     7140

cagctgtgga atgtgtgtca gttagggtgt ggaaagtccc caggctcccc agcaggcaga     7200

agtatgcaaa gcatgcatct caattagtca gcaaccaggt gtggaaagtc cccaggctcc     7260

ccagcaggca gaagtatgca aagcatgcat ctcaattagt cagcaaccat agtcccgccc     7320

ctaactccgc ccatcccgcc cctaactccg cccagttccg cccattctcc gccccatggc     7380

tgactaattt tttttattta tgcagaggcc gaggccgcct cggcctctga gctattccag     7440

aagtagtgag gaggcttttt tggaggccta ggcttttgca aaaagcttgg acacaagaca     7500

ggcttgcgag atatgtttga gaataccact ttatcccgcg tcagggagag gcagtgcgta     7560

aaaagacgcg gactcatgtg aaatactggt ttttagtgcg ccagatctct ataatctcgc     7620

gcaacctatt ttcccctcga acacttttta agccgtagat aaacaggctg ggacacttca     7680

catgagcgaa aaatacatcg tcacctggga catgttgcag atccatgcac gtaaactcgc     7740

aagccgactg atgccttctg aacaatggaa aggcattatt gccgtaagcc gtggcggtct     7800

gtaccgggtg cgttactggc gcgtgaactg ggtattcgtc atgtcgatac cgtttgtatt     7860

tccagctacg atcacgacaa ccagcgcgag cttaaagtgc tgaaacgcgc agaaggcgat     7920

ggcgaaggct tcatcgttat tgatgacctg gtggataccg gtggtactgc ggttgcgatt     7980

cgtgaaatgt atccaaaagc gcactttgtc accatcttcg caaaaccggc tggtcgtccg     8040

ctggttgatg actatgttgt tgatatcccg caagatacct ggattgaaca gccgtgggat     8100

atgggcgtcg tattcgtccc gccaatctcc ggtcgctaat cttttcaacg cctggcactg     8160

ccgggcgttg ttctttttaa cttcaggcgg gttacaatag tttccagtaa gtattctgga     8220

ggctgcatcc atgacacagg caaacctgag cgaaaccctg ttcaaacccc gctttaaaca     8280

tcctgaaacc tcgacgctag tccgccgctt taatcacggc gcacaaccgc ctgtgcagtc     8340

ggcccttgat ggtaaaacca tccctcactg gtatcgcatg attaaccgtc tgatgtggat     8400

ctggcgcggc attgacccac gcgaaatcct cgacgtccag gcacgtattg tgatgagcga     8460

tgccgaacgt accgacgatg atttatacga tacggtgatt ggctaccgtg gcggcaactg     8520

gatttatgag tgggccccgg atctttgtga aggaacctta cttctgtggt gtgacataat     8580

tggacaaact acctacagag atttaaagct ctaaggtaaa tataaaattt ttaagtgtat     8640

aatgtgttaa actactgatt ctaattgttt gtgtatttta gattccaacc tatggaactg     8700

atgaatggga gcagtggtgg aatgccttta atgaggaaaa cctgttttgc tcagaagaaa     8760

tgccatctag tgatgatgag gctactgctg actctcaaca ttctactcct ccaaaaaaga     8820

agagaaaggt agaagacccc aaggactttc cttcagaatt gctaagtttt ttgagtcatg     8880

ctgtgtttag taatagaact cttgcttgct ttgctattta caccacaaag gaaaaagctg     8940

cactgctata caagaaaatt atggaaaaat attctgtaac ctttataagt aggcataaca     9000

gttataatca taacatactg ttttttctta ctccacacag gcatagagtg tctgctatta     9060

ataactatgc tcaaaaattg tgtaccttta gctttttaat ttgtaaaggg gttaataagg     9120

aatatttgat gtatagtgcc ttgactagag atcataatca gccataccac atttgtagag     9180

cttttacttg ctttaaaaaa cctcccacac ctccccctga acctgaaaca taaaatgaat     9240

gcaattgttg ttgttaactt gtttattgca gcttataatg gttacaaata aagcaatagc     9300

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa     9360

ctcatcaatg tatcttatca tgtgtggatc aactggataa ctcaagctaa ccaaaatcat     9420

cccaaacttc ccaccccata ccctattacc actgccaaat tacctgtggt ttcatttact     9480

ctaaacctgt gattcctctg aattattttc attttaaaga aattgtattt gttaaatatg     9540

tactacaaac ttagtagt                                                   9558


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon I of BDNF

<400>  17
tgttggggag acgagatttt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon I of BDNF

<400>  18
cgtggacgtt tgcttctttc                                                   20


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon IIa of BDNF

<400>  19
tacttcatcc agttccacca g                                                 21


<210>  20
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon IIa of BDNF

<400>  20
caagttgcct tgtccgt                                                      17


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon IIb of BDNF

<400>  21
aagctccggt tccaccag                                                     18


<210>  22
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon IIb of BDNF

<400>  22
tgcttctttc atgggcg                                                      17


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon IIc of BDNF

<400>  23
gtggtgtaag ccgcaaaga                                                    19


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon IIc of BDNF

<400>  24
cgtggacgtt tgcttctttc                                                   20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon III of BDNF

<400>  25
ctgagactgc gctccactc                                                    19


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon III of BDNF

<400>  26
gtggacgttt gcttctttca                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon VI of BDNF

<400>  27
gatccgagag ctttgtgtgg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon VI of BDNF

<400>  28
gtggacgttt gcttctttca                                                   20


<210>  29
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of exon IV of BDNF

<400>  29
cgccatgcaa tttccactat caataattta ac                                     32


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of exon IV of BDNF

<400>  30
gtttactttg acaagtagtg actgaaaaag                                        30


<210>  31
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  universal forward primer for PCR

<400>  31
tggatgccgc aaaca                                                        15


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  universal reverse primer for PCR

<400>  32
ccgggacttt ctccaggact                                                   20


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for amplifying a fragment of beta-actin

<400>  33
aggcatcctg accctgaag                                                    19


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for amplifying a fragment of beta-actin

<400>  34
gctcattgta gaaagtgtgg                                                   20


