                         SEQUENCE LISTING

<110>  Medical Research Council
 
<120>  Methods

<130>  MEDBY/P48959PC

<150>  GB 1011367.8
<151>  2010-07-06

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  4901
<212>  DNA
<213>  Homo sapiens

<400>  1
ggcgcgcgga gccaggtggg aggtgcgagg tggccgcgcg gggatcttgg gtgacagggc       60

accgagggaa ggaggacgcg agggcagcca ggccctaggg agcagggaga gtggctcggg      120

ctcagtcgcg tggccccagg aagaagaaat tgtcgagacg aataacatga ggtcatatag      180

aatcccactt ttggtgattt caagtcaaga aagtaaaagt aaaccattgc tatctttcac      240

cttaaatatc ctgtgtttta ttgctcagaa catccagttt ttctaatact catgatgtca      300

gaagggaaac ctcctgacaa aaaaaggcct cgtagaagct tatcaatcag caagaataag      360

aaaaaagcat ctaattctat tatttcgtgt tttaacaatg caccacctgc taaacttgcc      420

tgccccgttt gcagtaaaat ggtgcctaga tatgacttaa accggcacct tgatgaaatg      480

tgtgctaaca atgacttcgt tcaagtggat ccagggcagg ttggcttaat aaattcaaat      540

gtgtctatgg tagatttaac cagtgttacc ttagaagatg taacacctaa gaagtcacca      600

ccaccaaaga caaatttaac ccctggccaa agtgattcag caaaaaggga agtaaagcag      660

aagatcagtc cctactttaa aagtaatgat gtggtgtgca aaaatcaaga tgagctgaga      720

aatcgtagtg tgaaagtcat ttgtttggga agcctagcat ctaaattgtc cagaaaatac      780

gtaaaggcta aaaaatcaat agataaggat gaagaatttg ccggttctag tccacagagt      840

tccaaatcca cagttgttaa gagcctgatt gataactctt cagaaattga ggacgaggat      900

caaattttgg agaacagttc tcaaaaagaa aacgtgttta aatgtgattc tctaaaggaa      960

gagtgcattc ctgaacatat ggtaagagga agtaaaataa tggaagccga aagccaaaag     1020

gctacccggg aatgtgagaa atcagccctc acccctggat tctcagataa tgcgatcatg     1080

ttattctcac cagatttcac tcttaggaat acattaaagt ctacttcaga agacagtctt     1140

gtaaagcaag agtgtatcaa agaagtggtt gaaaaacgtg aggcatgtca ttgtgaagaa     1200

gtaaaaatga ctgttgcttc agaagctaaa atacagctgt cagattcaga ggcaaaatct     1260

catagttctg cagatgatgc ttctgcatgg agtaacatcc aagaggctcc tctgcaggat     1320

gacagttgct taaacaatga tatccctcac agcattcctt tggagcaggg gtcaagctgc     1380

aatggtcctg gtcaaacaac cggtcatcct tactaccttc ggagtttcct tgtggtgctg     1440

aaaaccgtac ttgagaatga agatgatatg ttgctctttg atgagcagga gaagggaatt     1500

gtaactaaat tttatcagtt atcagctact ggtcagaagt tatatgtaag gctctttcaa     1560

cgtaaattaa gctggattaa gatgaccaaa ttagagtatg aagagattgc cttagactta     1620

acacctgtga ttgaagaatt gacgaatgca ggctttctac agacagaatc tgagttgcaa     1680

gaactctctg aagtgcttga actcctttct gctcctgaac taaaatccct agccaagacc     1740

ttccacttgg tgaatcccaa tggacagaaa cagcagctgg tggacgcctt tctcaaattg     1800

gccaaacagc gttcagtctg cacttggggc aagaataagc ctggaattgg tgcagtgatt     1860

ttaaaaagag ccaaagcctt ggctggacag tcagtacgaa tctgtaaagg ccccagggct     1920

gtgttttccc gcatcttgct actgttttcg ttgaccgact caatggaaga tgaagacgcc     1980

gcttgtggag gtcagggaca gctttcaaca gtcctgttgg tcaacctcgg ccgaatggag     2040

tttcctagtt acaccatcaa tcggaaaacc cacatcttcc aagacagaga tgatcttatc     2100

agatatgcag cagccacgca catgctgagt gacatttctt ccgcaatggc caatgggaac     2160

tgggaagaag ctaaggagct cgctcagtgt gcaaaaaggg attggaacag actgaaaaac     2220

cacccttctc tgagatgcca cgaagattta ccactcttcc tgcggtgttt cactgttggg     2280

tggatttata caaggatttt gtctcggttt gtggaaatac tgcagagact tcacatgtat     2340

gaggaagccg tcagagaact tgaaagcctt ttgtctcaga gaatttattg tcctgacagc     2400

agaggccgat ggtgggatcg actggccctt aatttacacc agcacttgaa gcgcctggaa     2460

ccgactatca agtgcatcac agaggggctg gcggatccgg aagtcagaac gggacaccgc     2520

ctttcactgt atcagcgagc cgtgcgcctg cgagagtctc cgagctgtaa aaagttcaag     2580

cacctcttcc agcagctccc agaaatggct gtgcaagatg tgaaacacgt gaccatcaca     2640

ggcaggctgt gcccacagcg tgggatgtgc aagtctgtgt ttgtgatgga ggccggggag     2700

gccgctgacc ccaccacggt cctgtgctct gtggaggagc tggcactggc ccattacaga     2760

cgcagcggtt ttgaccaggg gattcatggc gaagggtcca ccttcagcac cctgtatggc     2820

ctcctcctgt gggacatcat cttcatggat gggattccgg atgtcttcag aaacgcctgt     2880

caggcattcc ccctggactt gtgcacagac agcttcttca caagcagacg cccagccctt     2940

gaggccaggc tgcagctgat tcatgatgcc cccgaggaga gcctgcgggc ctgggtggca     3000

gccacgtggc atgagcagga aggcagagtg gcttcccttg tcagctggga tcgcttcacg     3060

tctcttcagc aagctcagga tcttgtctcc tgcctggggg gccctgtgct cagtggtgtg     3120

tgcaggcacc tggctgctga ctttcgacac tgtcgagggg gcctccccga cctggtggtg     3180

tggaactccc agagccgtca ctttaagctg gtggaagtta aaggccccaa tgatcgtctt     3240

tcacataagc agatgatctg gctggctgaa ctgcagaagc tgggggctga agtagaagtc     3300

tgccatgtgg ttgcagttgg agctaagagc caaagcctta gctaaaagat tccctacagg     3360

agaaaatgga aatgaggagg agagaaactc cggtgtcccc gaggtgtcgg tgtggtgagg     3420

gccgctggcg ttgaagtaca tcctgctctg gcccagctcc ccatagcagg cctccagggg     3480

gccactgcgc tgttgccgca gcatcctgct cagtacgtcg acttcatcag ccaggaggga     3540

gagcttgtga aaggctgtga tggagccacc caggctgatc tgggcctcgg gaacccagcg     3600

gaagtagcac agtttccaca gttttatgtg tgttccagag acacgtggca gaataacacc     3660

gtgcaggttg gcgggtttgg aaaaccattc tctaaaatac tgctccgtat cactgttctg     3720

gctgtcggtt tgctgagctg gatctggctt tggttttaat atcaatgaat ttctccttgg     3780

aagtaattct tggtcactga tgattccatt ctttaaggca gacggcattc ctcttagtgt     3840

ggagctgtag cttttctata cagaagagat tttattatgt tccggggatt ccctttttag     3900

aaagattgaa ggatgcaatg gcaaatataa actcaatact atgaaaaatt aatggaattt     3960

cagcctcaaa gaacattttc ctcccttcct ttgtgtcctt attctaatcc tcctcccctg     4020

gaattacact tttttatgtg ttgactctac ctaggctgtt actatcagcc tgaatggggg     4080

cgggatgaga gtacctccta tccactaatt tgcttaagga taagttctaa gacgggctag     4140

aaaaaacact agacctggcc gattctatca agaacaatgg caaactgaac agaggcagtc     4200

aggaggccaa atgtctgatt ctttgttctg tacctttcag tagtctgcaa attttctacc     4260

aaaaaaaatc ccaagaattt atttgggaat tattaaaaag gcaaacaatg aatgttatta     4320

ggacaagaat atagcagtca ggaggccatg actacatcac agccaggcgg cattccctgc     4380

cacagtggcg gcttgaatca tcaagaaatg gataaatggg gctttagtaa atcaggcttg     4440

caggctcaaa gctgcaatct gcccactctc aggtactgag actttgtggg cctcagacac     4500

caggaagaaa gctgggatac agtcatttga gttaaaaagg gaatgacccc tcagaaaccc     4560

gcattagcag tgttactctt ggaagtgcct ttacttttaa cgctctctgt tctgaaaaag     4620

aggtgtttgg ttacgtgtga gccaacatca cgttttgtta gctgtgattt acctttgtcc     4680

gtttaaaaga cttcacggag ccattctgta tacaaggtgt gctctttcca atgtagaagg     4740

ggttatggaa aagggtgcga tcctttgctg taaactggag agaccagtcc caaacagagg     4800

ggaattttaa gcccttctca tcacccaatt ggatgttttt gcttatagca aattcctgca     4860

aaataaataa ataaatattt gcaaaactaa aaaaaaaaaa a                         4901


<210>  2
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Ser Glu Gly Lys Pro Pro Asp Lys Lys Arg Pro Arg Arg Ser 
1               5                   10                  15      


Leu Ser Ile Ser Lys Asn Lys Lys Lys Ala Ser Asn Ser Ile Ile Ser 
            20                  25                  30          


Cys Phe Asn Asn Ala Pro Pro Ala Lys Leu Ala Cys Pro Val Cys Ser 
        35                  40                  45              


Lys Met Val Pro Arg Tyr Asp Leu Asn Arg His Leu Asp Glu Met Cys 
    50                  55                  60                  


Ala Asn Asn Asp Phe Val Gln Val Asp Pro Gly Gln Val Gly Leu Ile 
65                  70                  75                  80  


Asn Ser Asn Val Ser Met Val Asp Leu Thr Ser Val Thr Leu Glu Asp 
                85                  90                  95      


Val Thr Pro Lys Lys Ser Pro Pro Pro Lys Thr Asn Leu Thr Pro Gly 
            100                 105                 110         


Gln Ser Asp Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr 
        115                 120                 125             


Phe Lys Ser Asn Asp Val Val Cys Lys Asn Gln Asp Glu Leu Arg Asn 
    130                 135                 140                 


Arg Ser Val Lys Val Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser 
145                 150                 155                 160 


Arg Lys Tyr Val Lys Ala Lys Lys Ser Ile Asp Lys Asp Glu Glu Phe 
                165                 170                 175     


Ala Gly Ser Ser Pro Gln Ser Ser Lys Ser Thr Val Val Lys Ser Leu 
            180                 185                 190         


Ile Asp Asn Ser Ser Glu Ile Glu Asp Glu Asp Gln Ile Leu Glu Asn 
        195                 200                 205             


Ser Ser Gln Lys Glu Asn Val Phe Lys Cys Asp Ser Leu Lys Glu Glu 
    210                 215                 220                 


Cys Ile Pro Glu His Met Val Arg Gly Ser Lys Ile Met Glu Ala Glu 
225                 230                 235                 240 


Ser Gln Lys Ala Thr Arg Glu Cys Glu Lys Ser Ala Leu Thr Pro Gly 
                245                 250                 255     


Phe Ser Asp Asn Ala Ile Met Leu Phe Ser Pro Asp Phe Thr Leu Arg 
            260                 265                 270         


Asn Thr Leu Lys Ser Thr Ser Glu Asp Ser Leu Val Lys Gln Glu Cys 
        275                 280                 285             


Ile Lys Glu Val Val Glu Lys Arg Glu Ala Cys His Cys Glu Glu Val 
    290                 295                 300                 


Lys Met Thr Val Ala Ser Glu Ala Lys Ile Gln Leu Ser Asp Ser Glu 
305                 310                 315                 320 


Ala Lys Ser His Ser Ser Ala Asp Asp Ala Ser Ala Trp Ser Asn Ile 
                325                 330                 335     


Gln Glu Ala Pro Leu Gln Asp Asp Ser Cys Leu Asn Asn Asp Ile Pro 
            340                 345                 350         


His Ser Ile Pro Leu Glu Gln Gly Ser Ser Cys Asn Gly Pro Gly Gln 
        355                 360                 365             


Thr Thr Gly His Pro Tyr Tyr Leu Arg Ser Phe Leu Val Val Leu Lys 
    370                 375                 380                 


Thr Val Leu Glu Asn Glu Asp Asp Met Leu Leu Phe Asp Glu Gln Glu 
385                 390                 395                 400 


Lys Gly Ile Val Thr Lys Phe Tyr Gln Leu Ser Ala Thr Gly Gln Lys 
                405                 410                 415     


Leu Tyr Val Arg Leu Phe Gln Arg Lys Leu Ser Trp Ile Lys Met Thr 
            420                 425                 430         


Lys Leu Glu Tyr Glu Glu Ile Ala Leu Asp Leu Thr Pro Val Ile Glu 
        435                 440                 445             


Glu Leu Thr Asn Ala Gly Phe Leu Gln Thr Glu Ser Glu Leu Gln Glu 
    450                 455                 460                 


Leu Ser Glu Val Leu Glu Leu Leu Ser Ala Pro Glu Leu Lys Ser Leu 
465                 470                 475                 480 


Ala Lys Thr Phe His Leu Val Asn Pro Asn Gly Gln Lys Gln Gln Leu 
                485                 490                 495     


Val Asp Ala Phe Leu Lys Leu Ala Lys Gln Arg Ser Val Cys Thr Trp 
            500                 505                 510         


Gly Lys Asn Lys Pro Gly Ile Gly Ala Val Ile Leu Lys Arg Ala Lys 
        515                 520                 525             


Ala Leu Ala Gly Gln Ser Val Arg Ile Cys Lys Gly Pro Arg Ala Val 
    530                 535                 540                 


Phe Ser Arg Ile Leu Leu Leu Phe Ser Leu Thr Asp Ser Met Glu Asp 
545                 550                 555                 560 


Glu Asp Ala Ala Cys Gly Gly Gln Gly Gln Leu Ser Thr Val Leu Leu 
                565                 570                 575     


Val Asn Leu Gly Arg Met Glu Phe Pro Ser Tyr Thr Ile Asn Arg Lys 
            580                 585                 590         


Thr His Ile Phe Gln Asp Arg Asp Asp Leu Ile Arg Tyr Ala Ala Ala 
        595                 600                 605             


Thr His Met Leu Ser Asp Ile Ser Ser Ala Met Ala Asn Gly Asn Trp 
    610                 615                 620                 


Glu Glu Ala Lys Glu Leu Ala Gln Cys Ala Lys Arg Asp Trp Asn Arg 
625                 630                 635                 640 


Leu Lys Asn His Pro Ser Leu Arg Cys His Glu Asp Leu Pro Leu Phe 
                645                 650                 655     


Leu Arg Cys Phe Thr Val Gly Trp Ile Tyr Thr Arg Ile Leu Ser Arg 
            660                 665                 670         


Phe Val Glu Ile Leu Gln Arg Leu His Met Tyr Glu Glu Ala Val Arg 
        675                 680                 685             


Glu Leu Glu Ser Leu Leu Ser Gln Arg Ile Tyr Cys Pro Asp Ser Arg 
    690                 695                 700                 


Gly Arg Trp Trp Asp Arg Leu Ala Leu Asn Leu His Gln His Leu Lys 
705                 710                 715                 720 


Arg Leu Glu Pro Thr Ile Lys Cys Ile Thr Glu Gly Leu Ala Asp Pro 
                725                 730                 735     


Glu Val Arg Thr Gly His Arg Leu Ser Leu Tyr Gln Arg Ala Val Arg 
            740                 745                 750         


Leu Arg Glu Ser Pro Ser Cys Lys Lys Phe Lys His Leu Phe Gln Gln 
        755                 760                 765             


Leu Pro Glu Met Ala Val Gln Asp Val Lys His Val Thr Ile Thr Gly 
    770                 775                 780                 


Arg Leu Cys Pro Gln Arg Gly Met Cys Lys Ser Val Phe Val Met Glu 
785                 790                 795                 800 


Ala Gly Glu Ala Ala Asp Pro Thr Thr Val Leu Cys Ser Val Glu Glu 
                805                 810                 815     


Leu Ala Leu Ala His Tyr Arg Arg Ser Gly Phe Asp Gln Gly Ile His 
            820                 825                 830         


Gly Glu Gly Ser Thr Phe Ser Thr Leu Tyr Gly Leu Leu Leu Trp Asp 
        835                 840                 845             


Ile Ile Phe Met Asp Gly Ile Pro Asp Val Phe Arg Asn Ala Cys Gln 
    850                 855                 860                 


Ala Phe Pro Leu Asp Leu Cys Thr Asp Ser Phe Phe Thr Ser Arg Arg 
865                 870                 875                 880 


Pro Ala Leu Glu Ala Arg Leu Gln Leu Ile His Asp Ala Pro Glu Glu 
                885                 890                 895     


Ser Leu Arg Ala Trp Val Ala Ala Thr Trp His Glu Gln Glu Gly Arg 
            900                 905                 910         


Val Ala Ser Leu Val Ser Trp Asp Arg Phe Thr Ser Leu Gln Gln Ala 
        915                 920                 925             


Gln Asp Leu Val Ser Cys Leu Gly Gly Pro Val Leu Ser Gly Val Cys 
    930                 935                 940                 


Arg His Leu Ala Ala Asp Phe Arg His Cys Arg Gly Gly Leu Pro Asp 
945                 950                 955                 960 


Leu Val Val Trp Asn Ser Gln Ser Arg His Phe Lys Leu Val Glu Val 
                965                 970                 975     


Lys Gly Pro Asn Asp Arg Leu Ser His Lys Gln Met Ile Trp Leu Ala 
            980                 985                 990         


Glu Leu Gln Lys Leu Gly Ala Glu  Val Glu Val Cys His  Val Val Ala 
        995                 1000                 1005             


Val Gly  Ala Lys Ser Gln Ser  Leu Ser 
    1010                 1015         


<210>  3
<211>  5204
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcctggcgg gaaagtcgaa aactacgggc ggcgacggct tctcggaagt aatttaagtg       60

cacaagacat tggtcaaaat ggtttccaaa agaagactgt caaaatctga ggataaagag      120

agcctgacag aagatgcctc caaaaccagg aagcaaccac tttccaaaaa gacaaagaaa      180

tctcatattg ctaatgaagt tgaagaaaat gacagcatct ttgtaaagct tcttaagata      240

tcaggaatta ttcttaaaac gggagagagt cagaatcaac tagctgtgga tcaaatagct      300

ttccaaaaga agctctttca gaccctgagg agacaccctt cctatcccaa aataatagaa      360

gaatttgtta gtggcctgga gtcttacatt gaggatgaag acagtttcag gaactgcctt      420

ttgtcttgtg agcgtctgca ggatgaggaa gccagtatgg gtgcatctta ttctaagagt      480

ctcatcaaac tgcttctggg gattgacata ctgcagcctg ccattatcaa aaccttattt      540

gagaagttgc cagaatattt ttttgaaaac aagaacagtg atgaaatcaa catacctcga      600

ctcattgtca gtcaactaaa atggcttgac agagttgtgg atggcaagga cctcaccacc      660

aagatcatgc agctgatcag tattgctcca gagaacctgc agcatgacat catcaccagc      720

ctacctgaga tcctagggga ttcccagcac gctgatgtgg ggaaagaact cagtgaccta      780

ctgatagaga atacttcact cactgtccca atcctggatg tcctttcaag cctccgactt      840

gacccaaact tcctattgaa ggttcgccag ttggtgatgg ataagttgtc gtctattaga      900

ttggaggatt tacctgtgat aataaagttc attcttcatt ccgtaacagc catggataca      960

cttgaggtaa tttctgagct tcgggagaag ttggatctgc agcattgtgt tttgccatca     1020

cggttacagg cttcccaagt aaagttgaaa agtaaaggac gagcaagttc ctcaggaaat     1080

caagaaagca gcggtcagag ctgtattatt ctcctctttg atgtaataaa gtcagctatt     1140

agatatgaga aaaccatttc agaagcctgg attaaggcaa ttgaaaacac tgcctcagta     1200

tctgaacaca aggtgtttga cctggtgatg cttttcatca tctatagcac caatactcag     1260

acaaagaagt acattgacag ggtgctaaga aataagattc gatcaggctg cattcaagaa     1320

cagctgctcc agagtacatt ctctgttcat tacttagttc ttaaggatat gtgttcatcc     1380

attctgtcgc tggctcagag tttgcttcac tctctagacc agagtataat ttcatttggc     1440

agtctcctat acaaatatgc atttaagttt tttgacacgt actgccagca ggaagtggtt     1500

ggtgccttag tgacccatat ctgcagtggg aatgaagctg aagttgatac tgccttagat     1560

gtccttctag agttggtagt gttaaaccca tctgctatga tgatgaatgc tgtctttgta     1620

aagggcattt tagattatct ggataacata tcccctcagc aaatacgaaa actcttctat     1680

gttctcagca cactggcatt tagcaaacag aatgaagcca gcagccacat ccaggatgac     1740

atgcacttgg tgataagaaa gcagctctct agcaccgtat tcaagtacaa gctcattggg     1800

attattggtg ctgtgaccat ggctggcatc atggcggcag acagaagtga atcacctagt     1860

ttgacccaag agagagccaa cctgagcgat gagcagtgca cacaggtgac ctccttgttg     1920

cagttggttc attcctgcag tgagcagtct cctcaggcct ctgcacttta ctatgatgaa     1980

tttgccaacc tgatccaaca tgaaaagctg gatccaaaag ccctggaatg ggttgggcat     2040

accatctgta atgatttcca ggatgccttc gtagtggact cctgtgttgt tccggaaggt     2100

gactttccat ttcctgtgaa agcactgtac ggactggaag aatacgacac tcaggatggg     2160

attgccataa acctcctgcc gctgctgttt tctcaggact ttgcaaaaga tgggggtccg     2220

gtgacctcac aggaatcagg ccaaaaattg gtgtctccgc tgtgcctggc tccgtatttc     2280

cggttactga gactttgtgt ggagagacag cataacggaa acttggagga gattgatggt     2340

ctactagatt gtcctatatt cctaactgac ctggagcctg gagagaagtt ggagtccatg     2400

tctgctaaag agcgttcatt catgtgttct ctcatatttc ttactctcaa ctggttccga     2460

gagattgtaa atgccttctg ccaggaaaca tcacctgaga tgaaggggaa ggtgctcact     2520

cggttaaagc acattgtaga attgcaaata atcctggaaa agtacttggc agtcacccca     2580

gactatgtcc ctcctcttgg aaactttgat gtggaaactt tagatataac acctcatact     2640

gttactgcta tttcagcaaa aatcagaaag aaaggaaaaa tagaaaggaa acaaaaaaca     2700

gatggcagca agacatcctc ctctgacaca ctttcagaag agaaaaattc agaatgtgac     2760

cctacgccat ctcatagagg ccagctaaac aaggagttca cagggaagga agaaaagaca     2820

tcattgttac tacataattc ccatgctttt ttccgagagc tggacattga ggtcttctct     2880

attctacatt gtggacttgt gacgaagttc atcttagata ctgaaatgca cactgaagct     2940

acagaagttg tgcaacttgg gccccctgag ctgcttttct tgctggaaga tctctcccag     3000

aagctggaga gtatgctgac acctcctatt gccaggagag tcccctttct caagaacaaa     3060

ggaagccgga atattggatt ctcacatctc caacagagat ctgcccaaga aattgttcat     3120

tgtgtttttc aactgctgac cccaatgtgt aaccacctgg agaacattca caactatttt     3180

cagtgtttag ctgctgagaa tcacggtgta gttgatggac caggagtgaa agttcaggag     3240

taccacataa tgtcttcctg ctatcagagg ctgctgcaga tttttcatgg gctttttgct     3300

tggagtggat tttctcaacc tgaaaatcag aatttactgt attcagccct ccatgtcctt     3360

agtagccgac tgaaacaggg agaacacagc cagcctttgg aggaactact cagccagagc     3420

gtccattact tgcagaattt ccatcaaagc attcccagtt tccagtgtgc tctttatctc     3480

atcagacttt tgatggttat tttggagaaa tcaacagctt ctgctcagaa caaagaaaaa     3540

attgcttccc ttgccagaca attcctctgt cgggtgtggc caagtgggga taaagagaag     3600

agcaacatct ctaatgacca gctccatgct ctgctctgta tctacctgga gcacacagag     3660

agcattctga aggccataga ggagattgct ggtgttggtg tcccagaact gatcaactct     3720

cctaaagatg catcttcctc cacattccct acactgacca ggcatacttt tgttgttttc     3780

ttccgtgtga tgatggctga actagagaag acggtgaaaa aaattgagcc tggcacagca     3840

gcagactcgc agcagattca tgaagagaaa ctcctctact ggaacatggc tgttcgagac     3900

ttcagtatcc tcatcaactt gataaaggta tttgatagtc atcctgttct gcatgtatgt     3960

ttgaagtatg ggcgtctctt tgtggaagca tttctgaagc aatgtatgcc gctcctagac     4020

ttcagtttta gaaaacaccg ggaagatgtt ctgagcttac tggaaacctt ccagttggac     4080

acaaggctgc ttcatcacct gtgtgggcat tccaagattc accaggacac gagactcacc     4140

caacatgtgc ctctgctcaa aaagaccctg gaacttttag tttgcagagt caaagctatg     4200

ctcactctca acaattgtag agaggctttc tggctgggca atctaaaaaa ccgggacttg     4260

cagggtgaag agattaagtc ccaaaattcc caggagagca cagcagatga gagtgaggat     4320

gacatgtcat cccaggcctc caagagcaaa gccactgagg tatctctaca aaacccacca     4380

gagtctggca ctgatggttg cattttgtta attgttctaa gttggtggag cagaactttg     4440

cctacttatg tttattgtca aatgcttcta tgcccatttc cattccctcc ataacagctt     4500

ctgtgcttat ataatttttg ggacccagaa gaaacaacga cacaatctta gaatcactcc     4560

tgagtatctc gagttgtggc atttgttata gagttgacaa ttttctgcat tatagcctct     4620

cattttccat gaattcatat ctgaaaccat tttagaaggg agaagtcatc gaagtatttt     4680

ctgagtgttg agaagaatga gttaaaccat ttaaacacat ttgaaacata caaaaataga     4740

aatgtgaaag catttggtga aagccaaagc acagagtcag aagctgccac cttagagaac     4800

tgaaataaaa atagaagttc ttacgctttt ttgtggtaca gatgctttcg acaatttaaa     4860

gaaagctaaa taaaaatgta gacatggctg gcgcagtggc tcatgcttgt aatcctagca     4920

ctttttgagg ccaaggtagg aggattgctt gagtccggga gctcaaggca aagctgcaca     4980

acataacaag accctatctc cacaaaaaaa atgaaaaata aacctgggtg cggtggctca     5040

cacctgtaat cccagcactt tgggaggccg atgtgggcag atcacaaggt caggagttca     5100

agaccagcct ggccaacata gtgaaacccc atctctactg aaaatacaaa aattagctgg     5160

gtgtggtggc acgtgcctgt tatctcagct acttgggagg ctga                      5204


<210>  4
<211>  1471
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Val Ser Lys Arg Arg Leu Ser Lys Ser Glu Asp Lys Glu Ser Leu 
1               5                   10                  15      


Thr Glu Asp Ala Ser Lys Thr Arg Lys Gln Pro Leu Ser Lys Lys Thr 
            20                  25                  30          


Lys Lys Ser His Ile Ala Asn Glu Val Glu Glu Asn Asp Ser Ile Phe 
        35                  40                  45              


Val Lys Leu Leu Lys Ile Ser Gly Ile Ile Leu Lys Thr Gly Glu Ser 
    50                  55                  60                  


Gln Asn Gln Leu Ala Val Asp Gln Ile Ala Phe Gln Lys Lys Leu Phe 
65                  70                  75                  80  


Gln Thr Leu Arg Arg His Pro Ser Tyr Pro Lys Ile Ile Glu Glu Phe 
                85                  90                  95      


Val Ser Gly Leu Glu Ser Tyr Ile Glu Asp Glu Asp Ser Phe Arg Asn 
            100                 105                 110         


Cys Leu Leu Ser Cys Glu Arg Leu Gln Asp Glu Glu Ala Ser Met Gly 
        115                 120                 125             


Ala Ser Tyr Ser Lys Ser Leu Ile Lys Leu Leu Leu Gly Ile Asp Ile 
    130                 135                 140                 


Leu Gln Pro Ala Ile Ile Lys Thr Leu Phe Glu Lys Leu Pro Glu Tyr 
145                 150                 155                 160 


Phe Phe Glu Asn Lys Asn Ser Asp Glu Ile Asn Ile Pro Arg Leu Ile 
                165                 170                 175     


Val Ser Gln Leu Lys Trp Leu Asp Arg Val Val Asp Gly Lys Asp Leu 
            180                 185                 190         


Thr Thr Lys Ile Met Gln Leu Ile Ser Ile Ala Pro Glu Asn Leu Gln 
        195                 200                 205             


His Asp Ile Ile Thr Ser Leu Pro Glu Ile Leu Gly Asp Ser Gln His 
    210                 215                 220                 


Ala Asp Val Gly Lys Glu Leu Ser Asp Leu Leu Ile Glu Asn Thr Ser 
225                 230                 235                 240 


Leu Thr Val Pro Ile Leu Asp Val Leu Ser Ser Leu Arg Leu Asp Pro 
                245                 250                 255     


Asn Phe Leu Leu Lys Val Arg Gln Leu Val Met Asp Lys Leu Ser Ser 
            260                 265                 270         


Ile Arg Leu Glu Asp Leu Pro Val Ile Ile Lys Phe Ile Leu His Ser 
        275                 280                 285             


Val Thr Ala Met Asp Thr Leu Glu Val Ile Ser Glu Leu Arg Glu Lys 
    290                 295                 300                 


Leu Asp Leu Gln His Cys Val Leu Pro Ser Arg Leu Gln Ala Ser Gln 
305                 310                 315                 320 


Val Lys Leu Lys Ser Lys Gly Arg Ala Ser Ser Ser Gly Asn Gln Glu 
                325                 330                 335     


Ser Ser Gly Gln Ser Cys Ile Ile Leu Leu Phe Asp Val Ile Lys Ser 
            340                 345                 350         


Ala Ile Arg Tyr Glu Lys Thr Ile Ser Glu Ala Trp Ile Lys Ala Ile 
        355                 360                 365             


Glu Asn Thr Ala Ser Val Ser Glu His Lys Val Phe Asp Leu Val Met 
    370                 375                 380                 


Leu Phe Ile Ile Tyr Ser Thr Asn Thr Gln Thr Lys Lys Tyr Ile Asp 
385                 390                 395                 400 


Arg Val Leu Arg Asn Lys Ile Arg Ser Gly Cys Ile Gln Glu Gln Leu 
                405                 410                 415     


Leu Gln Ser Thr Phe Ser Val His Tyr Leu Val Leu Lys Asp Met Cys 
            420                 425                 430         


Ser Ser Ile Leu Ser Leu Ala Gln Ser Leu Leu His Ser Leu Asp Gln 
        435                 440                 445             


Ser Ile Ile Ser Phe Gly Ser Leu Leu Tyr Lys Tyr Ala Phe Lys Phe 
    450                 455                 460                 


Phe Asp Thr Tyr Cys Gln Gln Glu Val Val Gly Ala Leu Val Thr His 
465                 470                 475                 480 


Ile Cys Ser Gly Asn Glu Ala Glu Val Asp Thr Ala Leu Asp Val Leu 
                485                 490                 495     


Leu Glu Leu Val Val Leu Asn Pro Ser Ala Met Met Met Asn Ala Val 
            500                 505                 510         


Phe Val Lys Gly Ile Leu Asp Tyr Leu Asp Asn Ile Ser Pro Gln Gln 
        515                 520                 525             


Ile Arg Lys Leu Phe Tyr Val Leu Ser Thr Leu Ala Phe Ser Lys Gln 
    530                 535                 540                 


Asn Glu Ala Ser Ser His Ile Gln Asp Asp Met His Leu Val Ile Arg 
545                 550                 555                 560 


Lys Gln Leu Ser Ser Thr Val Phe Lys Tyr Lys Leu Ile Gly Ile Ile 
                565                 570                 575     


Gly Ala Val Thr Met Ala Gly Ile Met Ala Ala Asp Arg Ser Glu Ser 
            580                 585                 590         


Pro Ser Leu Thr Gln Glu Arg Ala Asn Leu Ser Asp Glu Gln Cys Thr 
        595                 600                 605             


Gln Val Thr Ser Leu Leu Gln Leu Val His Ser Cys Ser Glu Gln Ser 
    610                 615                 620                 


Pro Gln Ala Ser Ala Leu Tyr Tyr Asp Glu Phe Ala Asn Leu Ile Gln 
625                 630                 635                 640 


His Glu Lys Leu Asp Pro Lys Ala Leu Glu Trp Val Gly His Thr Ile 
                645                 650                 655     


Cys Asn Asp Phe Gln Asp Ala Phe Val Val Asp Ser Cys Val Val Pro 
            660                 665                 670         


Glu Gly Asp Phe Pro Phe Pro Val Lys Ala Leu Tyr Gly Leu Glu Glu 
        675                 680                 685             


Tyr Asp Thr Gln Asp Gly Ile Ala Ile Asn Leu Leu Pro Leu Leu Phe 
    690                 695                 700                 


Ser Gln Asp Phe Ala Lys Asp Gly Gly Pro Val Thr Ser Gln Glu Ser 
705                 710                 715                 720 


Gly Gln Lys Leu Val Ser Pro Leu Cys Leu Ala Pro Tyr Phe Arg Leu 
                725                 730                 735     


Leu Arg Leu Cys Val Glu Arg Gln His Asn Gly Asn Leu Glu Glu Ile 
            740                 745                 750         


Asp Gly Leu Leu Asp Cys Pro Ile Phe Leu Thr Asp Leu Glu Pro Gly 
        755                 760                 765             


Glu Lys Leu Glu Ser Met Ser Ala Lys Glu Arg Ser Phe Met Cys Ser 
    770                 775                 780                 


Leu Ile Phe Leu Thr Leu Asn Trp Phe Arg Glu Ile Val Asn Ala Phe 
785                 790                 795                 800 


Cys Gln Glu Thr Ser Pro Glu Met Lys Gly Lys Val Leu Thr Arg Leu 
                805                 810                 815     


Lys His Ile Val Glu Leu Gln Ile Ile Leu Glu Lys Tyr Leu Ala Val 
            820                 825                 830         


Thr Pro Asp Tyr Val Pro Pro Leu Gly Asn Phe Asp Val Glu Thr Leu 
        835                 840                 845             


Asp Ile Thr Pro His Thr Val Thr Ala Ile Ser Ala Lys Ile Arg Lys 
    850                 855                 860                 


Lys Gly Lys Ile Glu Arg Lys Gln Lys Thr Asp Gly Ser Lys Thr Ser 
865                 870                 875                 880 


Ser Ser Asp Thr Leu Ser Glu Glu Lys Asn Ser Glu Cys Asp Pro Thr 
                885                 890                 895     


Pro Ser His Arg Gly Gln Leu Asn Lys Glu Phe Thr Gly Lys Glu Glu 
            900                 905                 910         


Lys Thr Ser Leu Leu Leu His Asn Ser His Ala Phe Phe Arg Glu Leu 
        915                 920                 925             


Asp Ile Glu Val Phe Ser Ile Leu His Cys Gly Leu Val Thr Lys Phe 
    930                 935                 940                 


Ile Leu Asp Thr Glu Met His Thr Glu Ala Thr Glu Val Val Gln Leu 
945                 950                 955                 960 


Gly Pro Pro Glu Leu Leu Phe Leu Leu Glu Asp Leu Ser Gln Lys Leu 
                965                 970                 975     


Glu Ser Met Leu Thr Pro Pro Ile Ala Arg Arg Val Pro Phe Leu Lys 
            980                 985                 990         


Asn Lys Gly Ser Arg Asn Ile Gly  Phe Ser His Leu Gln  Gln Arg Ser 
        995                 1000                 1005             


Ala Gln  Glu Ile Val His Cys  Val Phe Gln Leu Leu  Thr Pro Met 
    1010                 1015                 1020             


Cys Asn  His Leu Glu Asn Ile  His Asn Tyr Phe Gln  Cys Leu Ala 
    1025                 1030                 1035             


Ala Glu  Asn His Gly Val Val  Asp Gly Pro Gly Val  Lys Val Gln 
    1040                 1045                 1050             


Glu Tyr  His Ile Met Ser Ser  Cys Tyr Gln Arg Leu  Leu Gln Ile 
    1055                 1060                 1065             


Phe His  Gly Leu Phe Ala Trp  Ser Gly Phe Ser Gln  Pro Glu Asn 
    1070                 1075                 1080             


Gln Asn  Leu Leu Tyr Ser Ala  Leu His Val Leu Ser  Ser Arg Leu 
    1085                 1090                 1095             


Lys Gln  Gly Glu His Ser Gln  Pro Leu Glu Glu Leu  Leu Ser Gln 
    1100                 1105                 1110             


Ser Val  His Tyr Leu Gln Asn  Phe His Gln Ser Ile  Pro Ser Phe 
    1115                 1120                 1125             


Gln Cys  Ala Leu Tyr Leu Ile  Arg Leu Leu Met Val  Ile Leu Glu 
    1130                 1135                 1140             


Lys Ser  Thr Ala Ser Ala Gln  Asn Lys Glu Lys Ile  Ala Ser Leu 
    1145                 1150                 1155             


Ala Arg  Gln Phe Leu Cys Arg  Val Trp Pro Ser Gly  Asp Lys Glu 
    1160                 1165                 1170             


Lys Ser  Asn Ile Ser Asn Asp  Gln Leu His Ala Leu  Leu Cys Ile 
    1175                 1180                 1185             


Tyr Leu  Glu His Thr Glu Ser  Ile Leu Lys Ala Ile  Glu Glu Ile 
    1190                 1195                 1200             


Ala Gly  Val Gly Val Pro Glu  Leu Ile Asn Ser Pro  Lys Asp Ala 
    1205                 1210                 1215             


Ser Ser  Ser Thr Phe Pro Thr  Leu Thr Arg His Thr  Phe Val Val 
    1220                 1225                 1230             


Phe Phe  Arg Val Met Met Ala  Glu Leu Glu Lys Thr  Val Lys Lys 
    1235                 1240                 1245             


Ile Glu  Pro Gly Thr Ala Ala  Asp Ser Gln Gln Ile  His Glu Glu 
    1250                 1255                 1260             


Lys Leu  Leu Tyr Trp Asn Met  Ala Val Arg Asp Phe  Ser Ile Leu 
    1265                 1270                 1275             


Ile Asn  Leu Ile Lys Val Phe  Asp Ser His Pro Val  Leu His Val 
    1280                 1285                 1290             


Cys Leu  Lys Tyr Gly Arg Leu  Phe Val Glu Ala Phe  Leu Lys Gln 
    1295                 1300                 1305             


Cys Met  Pro Leu Leu Asp Phe  Ser Phe Arg Lys His  Arg Glu Asp 
    1310                 1315                 1320             


Val Leu  Ser Leu Leu Glu Thr  Phe Gln Leu Asp Thr  Arg Leu Leu 
    1325                 1330                 1335             


His His  Leu Cys Gly His Ser  Lys Ile His Gln Asp  Thr Arg Leu 
    1340                 1345                 1350             


Thr Gln  His Val Pro Leu Leu  Lys Lys Thr Leu Glu  Leu Leu Val 
    1355                 1360                 1365             


Cys Arg  Val Lys Ala Met Leu  Thr Leu Asn Asn Cys  Arg Glu Ala 
    1370                 1375                 1380             


Phe Trp  Leu Gly Asn Leu Lys  Asn Arg Asp Leu Gln  Gly Glu Glu 
    1385                 1390                 1395             


Ile Lys  Ser Gln Asn Ser Gln  Glu Ser Thr Ala Asp  Glu Ser Glu 
    1400                 1405                 1410             


Asp Asp  Met Ser Ser Gln Ala  Ser Lys Ser Lys Ala  Thr Glu Val 
    1415                 1420                 1425             


Ser Leu  Gln Asn Pro Pro Glu  Ser Gly Thr Asp Gly  Cys Ile Leu 
    1430                 1435                 1440             


Leu Ile  Val Leu Ser Trp Trp  Ser Arg Thr Leu Pro  Thr Tyr Val 
    1445                 1450                 1455             


Tyr Cys  Gln Met Leu Leu Cys  Pro Phe Pro Phe Pro  Pro 
    1460                 1465                 1470     


<210>  5
<211>  4749
<212>  DNA
<213>  Homo sapiens

<400>  5
tcttgttgtt acgggtaacg gaagtgtggc ggcgttgggt tgagcgggct ttttggaagt       60

ttgtggcgga gttctgtgat atgagcaaca atggaccaga agattttatc tctagcagca      120

gaaaaaacag cagacaaact gcaagaattt cttcaaaccc tgagagaagg tgatttgact      180

aatctccttc agaatcaagc agtgaaagga aaagttgctg gagcactcct gagagccatc      240

ttcaaaggtt ccccctgctc tgaggaagct ggaacactta ggagacgtaa gatatacact      300

tgttgtatcc agttggtgga atcgggggat ttgcagaaag aaatagcgtc tgagatcata      360

ggattactga tgctggaggc tcaccatttt ccaggaccat tattggttga attagccaat      420

gagtttatta gtgctgtcag agaaggcagc ctagtgaatg gaaaatcttt ggagttacta      480

cctatcattc tcactgccct ggctacgaaa aaggaaaatc tggcttatgg aaaaggtgta      540

ctgagtgggg aagaatgtaa gaaacagttg attaacaccc tgtgttctgg caggtgggat      600

cagcaatatg taatccaact cacctccatg ttcaaggatg tccctctgac tgcagaagag      660

gtggaatttg tggtggaaaa agcattgagc atgttctcca agatgaatct tcaagaaata      720

ccacctttgg tctatcagct tctggttctc tcctccaagg gaagcagaaa gagtgttttg      780

gaaggaatca tagccttctt cagtgcacta gataagcagc acaatgagga acagagtggt      840

gacgagctat tggatgttgt cactgtgcca tcaggtgaac ttcgtcatgt ggaaggcacc      900

attattctac acattgtgtt tgccatcaaa ttggactatg aactaggcag agaactcgtg      960

aaacacttaa aggtaggaca gcaaggagat tccaataata acttaagtcc cttcagcatt     1020

gctcttcttc tgtctgtaac aagaatacaa agatttcagg accaggtgct tgatctttta     1080

aagacttcgg ttgtaaagag ctttaaggat cttcaactcc tccaaggctc aaaatttctt     1140

cagaatctag ttcctcatag atcttatgtt tcaaccatga tcttggaagt agtgaagaat     1200

agcgttcata gctgggacca tgttactcag ggcctcgtag aacttggttt cattttgatg     1260

gattcatatg ggccaaagaa ggttcttgat ggaaaaacta ttgaaaccag cccaagtctt     1320

tctagaatgc caaaccagca tgcatgtaag ctcggagcta atatcctgtt ggaaactttt     1380

aagatccatg agatgatcag acaagaaatt ttggagcagg tcctcaacag ggttgttacc     1440

agagcatctt ctcccatcag tcatttctta gacctgcttt caaatatcgt catgtatgca     1500

cccttagttc ttcaaagttg ttcttctaaa gtcacagaag cttttgacta tttgtccttt     1560

ctgccccttc agactgtaca aaggctgctt aaggcagtgc agccccttct caaagtcagc     1620

atgtcaatga gagactgctt gatacttgtc cttcggaaag ctatgtttgc caaccagctt     1680

gatgcccgaa aatctgcagt tgctgggttt ttgctgctcc tgaagaactt taaagtttta     1740

ggcagcctgt catcctctca gtgcagtcag tctctcagtg tcagtcaggt tcatgtggat     1800

gttcacagcc attacaattc tgtcgccaat gaaacttttt gccttgagat catggatagt     1860

ttgaggagat gcttaagcca gcaagctgat gttcgactca tgctttatga ggggttttat     1920

gatgttcttc gaaggaactc tcagctggct aattcagtca tgcaaactct gctctcacag     1980

ttaaaacagt tctatgagcc aaaacctgat ctgctgcctc ctctgaaatt agaagcttgt     2040

attctgaccc aaggagataa gatctctcta caagaaccac tggattatct gctgtgttgt     2100

attcagcatt gtttggcctg gtataagaat acagtcatac ccttacagca gggagaggag     2160

gaagaggagg aggaagaggc attctacgaa gacctagatg atatattgga gtccattact     2220

aatagaatga ttaagagtga gctggaagac tttgaactgg ataaatcagc agatttttct     2280

cagagcacca gtattggcat aaaaaataat atctgtgctt ttcttgtgat gggagtttgt     2340

gaggttttaa tagaatacaa tttctccata agtagtttca gtaagaatag gtttgaggac     2400

attctgagct tatttatgtg ttacaaaaaa ctctctgaca ttcttaatga aaaagcgggt     2460

aaagccaaaa ctaaaatggc caacaagaca agtgatagtc ttttgtccat gaaatttgtg     2520

tccagtcttc tcactgctct tttcagggat agtatccaaa gccaccaaga aagcctttct     2580

gttctcaggt ccagcaatga gtttatgcgc tatgcagtga atgtagctct gcagaaagta     2640

cagcagctaa aggaaacagg gcatgtgagt ggccctgatg gccaaaaccc agaaaagatc     2700

tttcagaacc tctgtgacat aactcgagtc ttgctatgga gatacacttc aattcctact     2760

tcagtggaag agtcgggaaa gaaagagaaa ggaaagagca tctcactgct gtgcttggag     2820

ggtttacaga aaatattcag tgctgtgcaa cagttctatc agcccaagat tcagcagttt     2880

ctcagagctc tggatgtcac agataaggaa ggagaagaga gagaagatgc agatgtcagt     2940

gtcactcaga gaacagcatt ccagatccgg caatttcaga ggtccttgtt gaatttactt     3000

agcagtcaag aggaagattt taatagcaaa gaagccctcc tgctagtcac ggttcttacc     3060

agtttgtcca agttactgga gccctcctct cctcagtttg tgcagatgtt atcctggaca     3120

tcaaagattt gcaaggaaaa cagccgggag gatgccttgt tttgcaagag cttgatgaac     3180

ttgctcttca gcctgcatgt ttcgtataag agtcctgtca ttctgctgcg tgacttgtcc     3240

caggatatcc acgggcatct gggagatata gaccaggatg tagaggtgga gaaaacaaac     3300

cactttgcaa tagtgaattt gagaacggct gcccccactg tctgtttact tgttctgagt     3360

caggccgaga aggttctaga agaagtggac tggctaatca ccaagcttaa gggacaagtg     3420

agccaagaaa ccttatcaga agaggcctct tctcaggcaa ccctaccaaa tcagcctgtt     3480

gagaaagcta tcatcatgca actgggaact ctgcttacat ttttccacga gctggtgcag     3540

acagctctgc catcaggcag ctgtgtggac accttgttaa aggacttgtg caaaatgtac     3600

accacactta cagcccttgt cagatattat ctccaggtgt gtcagagctc cggaggaatt     3660

ccaaaaaata tggaaaagct ggtgaagctg tctggttctc atctgacccc cctgtgttat     3720

tctttcattt cttacgtaca gaataagagt aagagcctga actatacggg agagaaaaag     3780

gagaaacctg ctgccgttgc cacagccatg gccagagttc ttcgggaaac caagccaatc     3840

cctaacctca tctttgccat agaacagtat gaaaaatttc tcatccacct ttctaagaag     3900

tccaaggtga acctgatgca gcacatgaag ctcagcacct cacgagactt caagatcaaa     3960

ggaaacatcc tagacatggt tcttcgagag gatggtgaag atgaaaatga agagggcact     4020

gcatcagagc atgggggaca gaacaaagaa ccagccaaga agaaaaggaa aaaataaatg     4080

aaatgcctga gttaatgtga actttggggc ttctgcttca tttttaccca acaagcaaca     4140

atgccccttg tcctgtagtc cacaccgatg ttggcatctt ggttctgaac ccactgaatt     4200

caactgcacc ttcagttaga aggaatcttc ttggcaggtc ctgctactga aaaatggctg     4260

gccttaggca agcccttttg caaaaagcac agctgaaagc ctgagtttgg gagcctgcac     4320

caccccgatg aagctccacg ggagcaaata cagagcctcc aggcagtgct atggtccagg     4380

ctggcttcgt ttttccaagg agcctttggt gagttcaatt atctggtaaa tatccagcgc     4440

ttcacctgaa agatagtgca aattggttag gatgccacct caagaactgt aactgagagc     4500

tcagaagtga gcaaaggagc ttaatgctaa ggtcaaaagg agagtgaaag gttgagaaca     4560

attgccacga acggtaatgt tacatgttag gagggtctgt tttcttttta tataagtgtg     4620

tcttagatat attttaaata gaaaataagc tttctgattt acttgtttgg tatttaaagc     4680

acagtttgtt tttctgtcac ctatagagtg caagaatgca ctctatagaa taaattatct     4740

ttaaacatt                                                             4749


<210>  6
<211>  1328
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Gln Lys Ile Leu Ser Leu Ala Ala Glu Lys Thr Ala Asp Lys 
1               5                   10                  15      


Leu Gln Glu Phe Leu Gln Thr Leu Arg Glu Gly Asp Leu Thr Asn Leu 
            20                  25                  30          


Leu Gln Asn Gln Ala Val Lys Gly Lys Val Ala Gly Ala Leu Leu Arg 
        35                  40                  45              


Ala Ile Phe Lys Gly Ser Pro Cys Ser Glu Glu Ala Gly Thr Leu Arg 
    50                  55                  60                  


Arg Arg Lys Ile Tyr Thr Cys Cys Ile Gln Leu Val Glu Ser Gly Asp 
65                  70                  75                  80  


Leu Gln Lys Glu Ile Ala Ser Glu Ile Ile Gly Leu Leu Met Leu Glu 
                85                  90                  95      


Ala His His Phe Pro Gly Pro Leu Leu Val Glu Leu Ala Asn Glu Phe 
            100                 105                 110         


Ile Ser Ala Val Arg Glu Gly Ser Leu Val Asn Gly Lys Ser Leu Glu 
        115                 120                 125             


Leu Leu Pro Ile Ile Leu Thr Ala Leu Ala Thr Lys Lys Glu Asn Leu 
    130                 135                 140                 


Ala Tyr Gly Lys Gly Val Leu Ser Gly Glu Glu Cys Lys Lys Gln Leu 
145                 150                 155                 160 


Ile Asn Thr Leu Cys Ser Gly Arg Trp Asp Gln Gln Tyr Val Ile Gln 
                165                 170                 175     


Leu Thr Ser Met Phe Lys Asp Val Pro Leu Thr Ala Glu Glu Val Glu 
            180                 185                 190         


Phe Val Val Glu Lys Ala Leu Ser Met Phe Ser Lys Met Asn Leu Gln 
        195                 200                 205             


Glu Ile Pro Pro Leu Val Tyr Gln Leu Leu Val Leu Ser Ser Lys Gly 
    210                 215                 220                 


Ser Arg Lys Ser Val Leu Glu Gly Ile Ile Ala Phe Phe Ser Ala Leu 
225                 230                 235                 240 


Asp Lys Gln His Asn Glu Glu Gln Ser Gly Asp Glu Leu Leu Asp Val 
                245                 250                 255     


Val Thr Val Pro Ser Gly Glu Leu Arg His Val Glu Gly Thr Ile Ile 
            260                 265                 270         


Leu His Ile Val Phe Ala Ile Lys Leu Asp Tyr Glu Leu Gly Arg Glu 
        275                 280                 285             


Leu Val Lys His Leu Lys Val Gly Gln Gln Gly Asp Ser Asn Asn Asn 
    290                 295                 300                 


Leu Ser Pro Phe Ser Ile Ala Leu Leu Leu Ser Val Thr Arg Ile Gln 
305                 310                 315                 320 


Arg Phe Gln Asp Gln Val Leu Asp Leu Leu Lys Thr Ser Val Val Lys 
                325                 330                 335     


Ser Phe Lys Asp Leu Gln Leu Leu Gln Gly Ser Lys Phe Leu Gln Asn 
            340                 345                 350         


Leu Val Pro His Arg Ser Tyr Val Ser Thr Met Ile Leu Glu Val Val 
        355                 360                 365             


Lys Asn Ser Val His Ser Trp Asp His Val Thr Gln Gly Leu Val Glu 
    370                 375                 380                 


Leu Gly Phe Ile Leu Met Asp Ser Tyr Gly Pro Lys Lys Val Leu Asp 
385                 390                 395                 400 


Gly Lys Thr Ile Glu Thr Ser Pro Ser Leu Ser Arg Met Pro Asn Gln 
                405                 410                 415     


His Ala Cys Lys Leu Gly Ala Asn Ile Leu Leu Glu Thr Phe Lys Ile 
            420                 425                 430         


His Glu Met Ile Arg Gln Glu Ile Leu Glu Gln Val Leu Asn Arg Val 
        435                 440                 445             


Val Thr Arg Ala Ser Ser Pro Ile Ser His Phe Leu Asp Leu Leu Ser 
    450                 455                 460                 


Asn Ile Val Met Tyr Ala Pro Leu Val Leu Gln Ser Cys Ser Ser Lys 
465                 470                 475                 480 


Val Thr Glu Ala Phe Asp Tyr Leu Ser Phe Leu Pro Leu Gln Thr Val 
                485                 490                 495     


Gln Arg Leu Leu Lys Ala Val Gln Pro Leu Leu Lys Val Ser Met Ser 
            500                 505                 510         


Met Arg Asp Cys Leu Ile Leu Val Leu Arg Lys Ala Met Phe Ala Asn 
        515                 520                 525             


Gln Leu Asp Ala Arg Lys Ser Ala Val Ala Gly Phe Leu Leu Leu Leu 
    530                 535                 540                 


Lys Asn Phe Lys Val Leu Gly Ser Leu Ser Ser Ser Gln Cys Ser Gln 
545                 550                 555                 560 


Ser Leu Ser Val Ser Gln Val His Val Asp Val His Ser His Tyr Asn 
                565                 570                 575     


Ser Val Ala Asn Glu Thr Phe Cys Leu Glu Ile Met Asp Ser Leu Arg 
            580                 585                 590         


Arg Cys Leu Ser Gln Gln Ala Asp Val Arg Leu Met Leu Tyr Glu Gly 
        595                 600                 605             


Phe Tyr Asp Val Leu Arg Arg Asn Ser Gln Leu Ala Asn Ser Val Met 
    610                 615                 620                 


Gln Thr Leu Leu Ser Gln Leu Lys Gln Phe Tyr Glu Pro Lys Pro Asp 
625                 630                 635                 640 


Leu Leu Pro Pro Leu Lys Leu Glu Ala Cys Ile Leu Thr Gln Gly Asp 
                645                 650                 655     


Lys Ile Ser Leu Gln Glu Pro Leu Asp Tyr Leu Leu Cys Cys Ile Gln 
            660                 665                 670         


His Cys Leu Ala Trp Tyr Lys Asn Thr Val Ile Pro Leu Gln Gln Gly 
        675                 680                 685             


Glu Glu Glu Glu Glu Glu Glu Glu Ala Phe Tyr Glu Asp Leu Asp Asp 
    690                 695                 700                 


Ile Leu Glu Ser Ile Thr Asn Arg Met Ile Lys Ser Glu Leu Glu Asp 
705                 710                 715                 720 


Phe Glu Leu Asp Lys Ser Ala Asp Phe Ser Gln Ser Thr Ser Ile Gly 
                725                 730                 735     


Ile Lys Asn Asn Ile Cys Ala Phe Leu Val Met Gly Val Cys Glu Val 
            740                 745                 750         


Leu Ile Glu Tyr Asn Phe Ser Ile Ser Ser Phe Ser Lys Asn Arg Phe 
        755                 760                 765             


Glu Asp Ile Leu Ser Leu Phe Met Cys Tyr Lys Lys Leu Ser Asp Ile 
    770                 775                 780                 


Leu Asn Glu Lys Ala Gly Lys Ala Lys Thr Lys Met Ala Asn Lys Thr 
785                 790                 795                 800 


Ser Asp Ser Leu Leu Ser Met Lys Phe Val Ser Ser Leu Leu Thr Ala 
                805                 810                 815     


Leu Phe Arg Asp Ser Ile Gln Ser His Gln Glu Ser Leu Ser Val Leu 
            820                 825                 830         


Arg Ser Ser Asn Glu Phe Met Arg Tyr Ala Val Asn Val Ala Leu Gln 
        835                 840                 845             


Lys Val Gln Gln Leu Lys Glu Thr Gly His Val Ser Gly Pro Asp Gly 
    850                 855                 860                 


Gln Asn Pro Glu Lys Ile Phe Gln Asn Leu Cys Asp Ile Thr Arg Val 
865                 870                 875                 880 


Leu Leu Trp Arg Tyr Thr Ser Ile Pro Thr Ser Val Glu Glu Ser Gly 
                885                 890                 895     


Lys Lys Glu Lys Gly Lys Ser Ile Ser Leu Leu Cys Leu Glu Gly Leu 
            900                 905                 910         


Gln Lys Ile Phe Ser Ala Val Gln Gln Phe Tyr Gln Pro Lys Ile Gln 
        915                 920                 925             


Gln Phe Leu Arg Ala Leu Asp Val Thr Asp Lys Glu Gly Glu Glu Arg 
    930                 935                 940                 


Glu Asp Ala Asp Val Ser Val Thr Gln Arg Thr Ala Phe Gln Ile Arg 
945                 950                 955                 960 


Gln Phe Gln Arg Ser Leu Leu Asn Leu Leu Ser Ser Gln Glu Glu Asp 
                965                 970                 975     


Phe Asn Ser Lys Glu Ala Leu Leu Leu Val Thr Val Leu Thr Ser Leu 
            980                 985                 990         


Ser Lys Leu Leu Glu Pro Ser Ser  Pro Gln Phe Val Gln  Met Leu Ser 
        995                 1000                 1005             


Trp Thr  Ser Lys Ile Cys Lys  Glu Asn Ser Arg Glu  Asp Ala Leu 
    1010                 1015                 1020             


Phe Cys  Lys Ser Leu Met Asn  Leu Leu Phe Ser Leu  His Val Ser 
    1025                 1030                 1035             


Tyr Lys  Ser Pro Val Ile Leu  Leu Arg Asp Leu Ser  Gln Asp Ile 
    1040                 1045                 1050             


His Gly  His Leu Gly Asp Ile  Asp Gln Asp Val Glu  Val Glu Lys 
    1055                 1060                 1065             


Thr Asn  His Phe Ala Ile Val  Asn Leu Arg Thr Ala  Ala Pro Thr 
    1070                 1075                 1080             


Val Cys  Leu Leu Val Leu Ser  Gln Ala Glu Lys Val  Leu Glu Glu 
    1085                 1090                 1095             


Val Asp  Trp Leu Ile Thr Lys  Leu Lys Gly Gln Val  Ser Gln Glu 
    1100                 1105                 1110             


Thr Leu  Ser Glu Glu Ala Ser  Ser Gln Ala Thr Leu  Pro Asn Gln 
    1115                 1120                 1125             


Pro Val  Glu Lys Ala Ile Ile  Met Gln Leu Gly Thr  Leu Leu Thr 
    1130                 1135                 1140             


Phe Phe  His Glu Leu Val Gln  Thr Ala Leu Pro Ser  Gly Ser Cys 
    1145                 1150                 1155             


Val Asp  Thr Leu Leu Lys Asp  Leu Cys Lys Met Tyr  Thr Thr Leu 
    1160                 1165                 1170             


Thr Ala  Leu Val Arg Tyr Tyr  Leu Gln Val Cys Gln  Ser Ser Gly 
    1175                 1180                 1185             


Gly Ile  Pro Lys Asn Met Glu  Lys Leu Val Lys Leu  Ser Gly Ser 
    1190                 1195                 1200             


His Leu  Thr Pro Leu Cys Tyr  Ser Phe Ile Ser Tyr  Val Gln Asn 
    1205                 1210                 1215             


Lys Ser  Lys Ser Leu Asn Tyr  Thr Gly Glu Lys Lys  Glu Lys Pro 
    1220                 1225                 1230             


Ala Ala  Val Ala Thr Ala Met  Ala Arg Val Leu Arg  Glu Thr Lys 
    1235                 1240                 1245             


Pro Ile  Pro Asn Leu Ile Phe  Ala Ile Glu Gln Tyr  Glu Lys Phe 
    1250                 1255                 1260             


Leu Ile  His Leu Ser Lys Lys  Ser Lys Val Asn Leu  Met Gln His 
    1265                 1270                 1275             


Met Lys  Leu Ser Thr Ser Arg  Asp Phe Lys Ile Lys  Gly Asn Ile 
    1280                 1285                 1290             


Leu Asp  Met Val Leu Arg Glu  Asp Gly Glu Asp Glu  Asn Glu Glu 
    1295                 1300                 1305             


Gly Thr  Ala Ser Glu His Gly  Gly Gln Asn Lys Glu  Pro Ala Lys 
    1310                 1315                 1320             


Lys Lys  Arg Lys Lys 
    1325             


<210>  7
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  FANCA mRNA target sequence

<400>  7
gggucaagag ggaaaaaua                                                    19


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  FAN1-1 mRNA target sequence

<400>  8
guaaggcucu uucaacgua                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  FAN1-2 mRNA target sequence

<400>  9
gcaggaaggc agaguggcu                                                    19


<210>  10
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MLH1 mRNA target sequence

<400>  10
gcauguggcu cauguuac                                                     18


<210>  11
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  ATR mRNA target sequence

<400>  11
gggagccugu ugagacaaga u                                                 21


<210>  12
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide a3

<400>  12
cctcgatcct accaaccaga tgacgcgctg ctacgtgcta ccggaagtcg                  50


<210>  13
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide b

<400>  13
cgacttccgg tagcacgtag cagcggctcg ccacgaactg cactctaggc                  50


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide c

<400>  14
gcctagagtg cagttcgtgg cgagc                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleoide d3

<400>  15
cgtcatctgg ttggtaggat cgagg                                             25


<210>  16
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide a3-cp

<400>  16
cgacttccgg tagcacgtag cagcgcgtca actggttggt aggatcgagg                  50


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide f7

<400>  17
attgactagg ttacatgact gaatgatagt                                        30


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide f8

<400>  18
ggagtaaagt actaggtatg tcgacattga                                        30


<210>  19
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide f9

<400>  19
actatcattc agtcatgtaa cctagtcaat ctgcgagctc gaattcactg gagtgacct        59


<210>  20
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide f10

<400>  20
gaggtcactc cagtgaattc gagctcgcag tcaatgtcga catacctagt actttactcc       60


<210>  21
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide a3-cp

<400>  21
cgacttccgg tagcacgtag cagcgcgtca actggttggt aggatcgagg                  50


<210>  22
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide a3-I25

<400>  22
cgctgctacg tgctaccgga agtcg                                             25


<210>  23
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Thr Asp Ser Phe Phe Thr Ser Arg Arg Pro Ala Leu Glu Ala Arg 
1               5                   10                  15      


Leu Gln Leu Ile His Asp Ala Pro Glu Glu Ser Leu Arg Ala Trp Val 
            20                  25                  30          


Ala Ala Thr Trp His Glu Gln Glu Gly Arg Val Ala Ser Leu Val Ser 
        35                  40                  45              


Trp Asp Arg Phe Thr Ser Leu Gln Gln Ala Gln Asp Leu Val Ser Cys 
    50                  55                  60                  


Leu Gly Gly Pro Val Leu Ser Gly Val Cys Arg His Leu Ala Ala Asp 
65                  70                  75                  80  


Phe Arg His Cys Arg Gly Gly Leu Pro Asp Leu Val Val Trp Asn Ser 
                85                  90                  95      


Gln Ser Arg His Phe Lys Leu Val Glu Val Lys Gly Pro Asn Asp Arg 
            100                 105                 110         


Leu Ser His Lys Gln Met Ile Trp Leu Ala Glu Leu Gln Lys Leu Gly 
        115                 120                 125             


Ala Glu Val Glu Val Cys His Val Val Ala Val 
    130                 135                 


<210>  24
<211>  139
<212>  PRT
<213>  Danio rerio

<400>  24

His Thr Asp Cys Phe Tyr Gly Ser Arg Arg Glu Ala Ile Glu Ala Arg 
1               5                   10                  15      


Ala Glu Met Leu Arg Glu Ala Ser Val Glu Thr Leu Gln Asp Leu Ile 
            20                  25                  30          


Ala Asp Val Trp Ser Thr Gln Glu Gly Arg Val Cys Ala Leu Ile Asn 
        35                  40                  45              


Trp Glu Arg Phe Ser Thr Pro Gln Gln Ala Gln Ser Leu Val Ala Cys 
    50                  55                  60                  


Leu Gly Gly His Phe Leu Ser Gly Val Phe Leu Arg Met Ala Lys Asp 
65                  70                  75                  80  


Tyr Arg His Cys Arg Gly Gly Leu Pro Asp Leu Val Val Trp Ser Thr 
                85                  90                  95      


Ser Ser Asn Lys Tyr Lys Leu Val Glu Val Lys Gly Pro Asn Asp Arg 
            100                 105                 110         


Leu Ser Gln Lys Gln Gln Ile Trp Leu Asp Glu Leu Arg Lys Leu Gly 
        115                 120                 125             


Ala Asp Val Glu Val Cys His Val Thr Ala Thr 
    130                 135                 


<210>  25
<211>  140
<212>  PRT
<213>  Caenorhabditis elegans

<400>  25

Leu Ser Asn Thr Leu Tyr Ser Lys Arg Lys Glu Lys Phe Glu Asp Arg 
1               5                   10                  15      


Phe Val Trp Leu Glu Glu Ala Glu Gln Glu Leu Ile Glu Glu Asn Ile 
            20                  25                  30          


Arg Lys Ile Trp Asp Leu Lys His Asn Glu Thr Asn Phe Glu Cys Ser 
        35                  40                  45              


Trp Lys Gln Phe Pro Met Gly Ala Glu Asp Cys Val Ser Phe Phe Gln 
    50                  55                  60                  


Cys Ile Pro Arg Pro Ala Leu Ile Leu Ile Leu Arg Arg Leu Ala Glu 
65                  70                  75                  80  


Asn Tyr Arg Asn Ser Arg Ser Gly Phe Pro Asp Leu Thr Leu Trp Asn 
                85                  90                  95      


Pro Glu Thr Lys Arg Val Ala Val Val Glu Val Lys Gly Pro Gly Asp 
            100                 105                 110         


Arg Leu Ser Thr Lys Gln Arg Leu Trp Leu Ala Ile Phe Ala Asp Ser 
        115                 120                 125             


Gly Ile Arg Ala Glu Val Cys His Val Ala Ala Gln 
    130                 135                 140 


<210>  26
<211>  136
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  26

His Thr Asp Ser Phe Tyr Ile Ser Arg Glu Ser Thr Ile Met Lys Arg 
1               5                   10                  15      


Leu Glu Glu Ile Arg Asn Gly Lys Ala Gly Leu Ile Ile Lys Asp Asn 
            20                  25                  30          


Tyr Ile Arg Glu His Gln Arg Lys Thr Phe Cys Val Gly Leu Asn Trp 
        35                  40                  45              


Ser Tyr Thr Cys Glu Met Leu Leu Glu Ile Val Asp Cys Ile Asn Asp 
    50                  55                  60                  


Asn Gly Leu Ala Gln Ile Phe Leu Ala Leu Thr Gln Asp Tyr Lys Asn 
65                  70                  75                  80  


Ser Ser Ser Gly Ile Pro Asp Leu Cys Leu Trp Asn Pro Ser Lys Lys 
                85                  90                  95      


Lys Phe Met Phe Ser Glu Val Lys Ser Asp Asn Asp Arg Leu Ser Glu 
            100                 105                 110         


Ala Gln Lys Phe Trp Ile Ser Leu Leu Ile Ser Ser Glu Val Asp Val 
        115                 120                 125             


Glu Val Cys His Val Ser Met His 
    130                 135     


<210>  27
<211>  139
<212>  PRT
<213>  Arabidopsis thaliana

<400>  27

Glu Thr Glu Ser Phe Tyr Leu Thr Arg Lys Glu Thr Ile Glu Ser Gln 
1               5                   10                  15      


Leu Glu Lys Val Ala Asn Gly Met Ala Glu Glu Ile Leu Ile Ile Ser 
            20                  25                  30          


Tyr Glu Thr Gln Arg Gly Thr Ala Cys Arg Gly Val Ala Trp Glu Arg 
        35                  40                  45              


Phe Ser Leu Glu Glu Leu Arg Ala Ala Val Ala Cys Val Gly Gly Met 
    50                  55                  60                  


Cys Ile Ala Ser Leu Cys Arg His Leu Ala Gln Asp Tyr Arg Ser Trp 
65                  70                  75                  80  


Cys Ser Gly Met Pro Asp Leu Leu Val Trp Arg Phe Lys Glu Asn Gly 
                85                  90                  95      


Tyr Glu Gly Glu Ala Lys Leu Val Glu Val Lys Ser Glu Lys Asp Arg 
            100                 105                 110         


Leu Ser Glu Gln Gln Arg Ala Trp Leu Leu Leu Leu Met Asp Ser Gly 
        115                 120                 125             


Phe Asn Val Glu Ile Cys Lys Val Arg Pro Ala 
    130                 135                 


<210>  28
<211>  139
<212>  PRT
<213>  Oryza sativa

<400>  28

Glu Thr Asp Glu Phe Tyr Arg Ser Arg Lys Asp Leu Ile Glu Ser Gln 
1               5                   10                  15      


Leu Lys Lys Ile Gln Asp Gly Ile Ala Glu Glu Ile Leu Ile Ser Ser 
            20                  25                  30          


Trp Glu Leu His Gln Gly Thr Ser Cys Arg Gly Val Asn Trp Asp Arg 
        35                  40                  45              


His Ser Leu Thr Asp Leu Arg Ala Ala Val Val Cys Thr Gly Gly His 
    50                  55                  60                  


Arg Leu Ala Ser Leu Leu Arg His Leu Ala Leu Asp Tyr Arg Ser Trp 
65                  70                  75                  80  


Ser Ser Gly Met Pro Asp Leu Leu Leu Trp Arg Phe Leu Asp Glu Arg 
                85                  90                  95      


Gly Gly Gly Glu Ala Lys Leu Val Glu Val Lys Gly Pro Arg Asp Gln 
            100                 105                 110         


Leu Ser Glu Gln Gln Arg Ala Trp Ile Leu Val Leu Met Asp Phe Gly 
        115                 120                 125             


Phe Asp Val Glu Val Cys Lys Val Ser Pro Val 
    130                 135                 


<210>  29
<211>  135
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  29

His Ser Ala Asp Phe Arg Gln Arg Arg Ala Ala Leu Phe Glu Ala Cys 
1               5                   10                  15      


Leu Gly Arg Leu Glu Asp Gly Ser Tyr Arg Asp Ala Ile Arg Cys Arg 
            20                  25                  30          


Tyr Arg Asp Lys Phe Gly Leu Gln Ser Pro Phe Val Tyr Trp Glu Leu 
        35                  40                  45              


Leu Gly Glu Glu Leu Leu Glu Gln Ala Leu Asp Cys Leu Pro Ala Ala 
    50                  55                  60                  


His Leu Arg Ala Trp Phe Glu Arg Leu Leu Glu Asp Ile Pro Gly Asn 
65                  70                  75                  80  


Arg Ala Gly Leu Pro Asp Leu Ile Gln Phe Trp Pro Ala Gln Arg Arg 
                85                  90                  95      


Tyr Arg Met Val Glu Val Lys Gly Pro Gly Asp Arg Leu Gln Asp Asn 
            100                 105                 110         


Gln Leu Arg Trp Leu Gln Phe Cys Arg Glu Arg Glu Met Pro Val Ala 
        115                 120                 125             


Val Cys Tyr Val Arg Trp His 
    130                 135 


<210>  30
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KIAA1018 sequence

<400>  30

Lys Leu Ala Cys Pro Val Cys Ser Lys Met Val Pro Arg Tyr Asp Leu 
1               5                   10                  15      


Asn Arg His Leu Asp Glu Met Cys Ala Asn Asn Asp Phe 
            20                  25                  


<210>  31
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POLK sequence 1

<400>  31

Ile Leu Thr Cys Pro Val Cys Phe Arg Ala Gln Gly Cys Ile Ser Leu 
1               5                   10                  15      


Glu Ala Leu Asn Lys His Val Asp Glu Cys Leu Asp Gly Pro Ser 
            20                  25                  30      


<210>  32
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POLK sequence 2

<400>  32

Ala Leu Val Cys Pro Val Cys Asn Val Glu Gln Lys Thr Ser Asp Leu 
1               5                   10                  15      


Thr Leu Phe Asn Val His Val Asp Val Cys Leu Asn Lys Ser Phe 
            20                  25                  30      


<210>  33
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RAD18 sequence

<400>  33

Lys Val Asp Cys Pro Val Cys Gly Val Asn Ile Pro Glu Ser His Ile 
1               5                   10                  15      


Asn Lys His Leu Asp Ser Cys Leu Ser Arg Glu Glu 
            20                  25              


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RNF220 sequence

<400>  34

Gly Gln Val Cys Pro Leu Cys Asn Arg Pro Leu Ala Gly Ser Glu Gln 
1               5                   10                  15      


Glu Met Ser Arg His Val Glu His Cys Leu Ser Lys Arg Glu 
            20                  25                  30  


<210>  35
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UIMC1 sequence 1

<400>  35

Gln Val Ser Cys Pro Leu Cys Asp Gln Cys Phe Pro Pro Thr Lys Ile 
1               5                   10                  15      


Glu Arg His Ala Met Tyr Cys Asn Gly Leu Met Glu 
            20                  25              


<210>  36
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UIMC1 sequence 2

<400>  36

Asn Glu Lys Cys Tyr Leu Cys Lys Ser Leu Val Pro Phe Arg Glu Tyr 
1               5                   10                  15      


Gln Cys His Val Asp Ser Cys Leu Gln Leu Ala Lys 
            20                  25              


<210>  37
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WRNIP

<400>  37

Gln Val Gln Cys Pro Val Cys Gln Gln Met Met Pro Ala Ala His Ile 
1               5                   10                  15      


Asn Ser His Leu Asp Arg Cys Leu Leu Leu His Pro 
            20                  25              


<210>  38
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZBTB1 sequence

<400>  38

Pro Phe Arg Cys Pro Asn Cys Gly Gln Arg Phe Glu Thr Glu Asn Leu 
1               5                   10                  15      


Val Val Glu His Met Ser Ser Cys Leu Asp 
            20                  25      


<210>  39
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZNRF1

<400>  39

Gly Phe Lys Cys Pro Ile Cys Ser Lys Ser Val Ala Ser Asp Glu Met 
1               5                   10                  15      


Glu Met His Phe Ile Met Cys Leu Ser Lys Pro Arg 
            20                  25              


<210>  40
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZNRF2 sequence

<400>  40

Gly Phe Lys Cys Pro Val Cys Ser Lys Phe Val Ser Ser Asp Glu Met 
1               5                   10                  15      


Asp Leu His Leu Val Met Cys Leu Thr Lys Pro Arg 
            20                  25              


<210>  41
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD12 sequence 1

<400>  41

Leu Phe Phe Cys Gln Ile Cys Gln Lys Asn Leu Ser Ala Met Asn Val 
1               5                   10                  15      


Thr Arg Arg Glu Gln His Val Asn Arg Cys Leu Asp Glu Ala Glu 
            20                  25                  30      


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTBD12 sequence 2

<400>  42

Ile Pro Glu Cys Pro Ile Cys Gly Lys Pro Phe Leu Thr Leu Lys Ser 
1               5                   10                  15      


Arg Thr Ser His Leu Lys Gln Cys Ala Val Lys Met Glu 
            20                  25                  


<210>  43
<211>  28
<212>  PRT
<213>  Artificial Seqence

<220>
<223>  C1ORF124 sequence

<400>  43

Met Val Asn Cys Pro Val Cys Gln Asn Glu Val Leu Glu Ser Gln Ile 
1               5                   10                  15      


Asn Glu His Leu Asp Trp Cys Leu Glu Gly Asp Ser 
            20                  25              


<210>  44
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DCLRE1A sequence

<400>  44

Asp Gly Tyr Cys Pro Asn Cys Gln Met Pro Phe Ser Ser Leu Ile Gly 
1               5                   10                  15      


Gln Thr Pro Arg Trp His Val Phe Glu Cys Leu Asp Ser Pro Pro 
            20                  25                  30      


<210>  45
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM164A sequence 1

<400>  45

Leu Leu Pro Cys Lys Ile Cys Gly Arg Thr Phe Phe Pro Val Ala Leu 
1               5                   10                  15      


Lys Lys His Gly Pro Ile Cys Gln Lys Thr Ala Thr 
            20                  25              


<210>  46
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAM164A sequence 2

<400>  46

Tyr Ile Gln Cys Pro Tyr Cys Gln Arg Arg Phe Asn Glu Asn Ala Ala 
1               5                   10                  15      


Asp Arg His Ile Asn Phe Cys Lys Glu Gln Ala Ala 
            20                  25              


<210>  47
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM164B sequence

<400>  47

Leu Phe Pro Cys Glu Val Cys Gly Arg Arg Phe Ala Ala Asp Val Leu 
1               5                   10                  15      


Glu Arg His Gly Pro Ile Cys Lys Lys Leu Phe Asn 
            20                  25              


<210>  48
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM164C sequence

<400>  48

Leu Gly Glu Cys Ser His Cys Gly Arg Lys Phe Leu Ser Phe Arg Leu 
1               5                   10                  15      


Glu Arg His Ser Asn Ile Cys Ser Arg Met Arg Gly 
            20                  25              


<210>  49
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of oligonucleotide a3

<400>  49
gacgcgctgc                                                              10


<210>  50
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Portion of oligonucleotide b

<400>  50
gcagcggctc                                                              10


<210>  51
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of oligonucleotide f9

<400>  51
caatctgcga                                                              10


<210>  52
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of oligonucleotide f10

<400>  52
tcgcagtcaa                                                              10


