                         SEQUENCE LISTING

<110>  PRONOTA N.V.
 
<120>  BIOMARKER FOR HYPERTENSIVE DISORDERS OF PREGNANCY

<130>  PRNO-034-PCT

<150>  EP10168881.0
<151>  2010-07-08

<150>  US 61/362,436
<151>  2010-07-08

<160>  5     

<170>  PatentIn version 3.3

<210>  1
<211>  3316
<212>  DNA
<213>  Homo sapiens

<400>  1
ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg     60

agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg    120

ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc    180

tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg    240

ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc    300

ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat    360

ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc    420

cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta    480

tttccagtgg ctggtgctga cgtgcagaca ctgcgggaga ggctcattga cgccctggag    540

tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag    600

attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga    660

ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg    720

cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc    780

tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc    840

aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag    900

accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat    960

cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa   1020

gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca   1080

gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat   1140

gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg   1200

gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg   1260

agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact   1320

gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc   1380

ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac   1440

ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc   1500

tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac   1560

ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa   1620

cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc   1680

tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg   1740

cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat   1800

tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat   1860

gtgccggctg agggacctga ggcaagtcga cccccgaagc tgcaccctgg cctcagagct   1920

gcaccaggcc aggagcctcc tgagcacatg gcagagcttc agaggaatga gcaggagcag   1980

ccgcttgggc agtggcactt gagcaagcga gacacagggg ctgcattgct ggctgagtcc   2040

agggctgaga agaaccgcct ctggggccct ttggaggtca ggcgcgtggg ccgcagctcc   2100

aagcagctgg tcgacatccc tgagggccag ctggaggccc gagctggacg gggccgaggc   2160

cagtggctgc aggtgctggg agggggcttc tcttacctgg acatcagcct ctgtgtgggg   2220

ctctattccc tgtccttcat gggcctgctg gccatgtaca cctacttcca ggccaagata   2280

agggccctga agggccatgc tggccaccct gcagcctgaa ccacctgggg aggaggcggg   2340

agagggagct gccatctcta ggcacctcaa gccccctgac cccattccct cccctcccac   2400

cccttgctcc ttgtctggcc tagaagtgtg ggaaattcag gaaaacgagt tgctccagtg   2460

aagcttcttg gggttgctag gacagagagc tcctttgaca caaaagacag gagcagggtc   2520

caggttcccc tgctgtgcag ggagggcagc cccgggcagt gggcataggg cagctcagtc   2580

cctggcctct tagcaccaca ttcctgtttt tcagcttatt tgaagtcctg cctcattctc   2640

actggagcct cagtctctcc tgcttggtct tggccctcaa ctggggcaag tgaagccaga   2700

ggagggtccc ccagctgggt gggctggaat ggaactcctc actagctgct ggggctccgc   2760

ccaccctgct cccttccgga caatgaagaa gcctttgcac cctgggagga aggaccaccc   2820

cgggccctct atgcctggcc agcctccagc tcctcagacc tcctgggtgg ggtttggctt   2880

cagggtgggg tttggaagct tctggaagtc gtgctggtct cccaggtgag gcaagccatg   2940

gttgctgggc tgtagggtga gtggcttgct tggtgggacc tgacgagttg gtggcatggg   3000

aaggatgtgg gtctctagtg ccttgccctg gcttagctgc aggagaagat ggctgctttc   3060

acttcccccc attgagctct gctccctctg agcctggtct tttgtccttt tttattttgg   3120

tctccaagat gaatgctcat ctttggaggg tgccaggtag aagctaggga ggggagtgtc   3180

ttctctctcc aggtttcacc ttccagtgtg cagaagttag aagggtctgg cgggggcagt   3240

gccttacaca tgcttgattc ccacgctacc ccctgccttg ggaggtgtgt ggaataaatt   3300

atttttgtta aggcaa                                                   3316


<210>  2
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Ala Ser Arg Pro Pro Lys 
        595                 600                 605             


Leu His Pro Gly Leu Arg Ala Ala Pro Gly Gln Glu Pro Pro Glu His 
    610                 615                 620                 


Met Ala Glu Leu Gln Arg Asn Glu Gln Glu Gln Pro Leu Gly Gln Trp 
625                 630                 635                 640 


His Leu Ser Lys Arg Asp Thr Gly Ala Ala Leu Leu Ala Glu Ser Arg 
                645                 650                 655     


Ala Glu Lys Asn Arg Leu Trp Gly Pro Leu Glu Val Arg Arg Val Gly 
            660                 665                 670         


Arg Ser Ser Lys Gln Leu Val Asp Ile Pro Glu Gly Gln Leu Glu Ala 
        675                 680                 685             


Arg Ala Gly Arg Gly Arg Gly Gln Trp Leu Gln Val Leu Gly Gly Gly 
    690                 695                 700                 


Phe Ser Tyr Leu Asp Ile Ser Leu Cys Val Gly Leu Tyr Ser Leu Ser 
705                 710                 715                 720 


Phe Met Gly Leu Leu Ala Met Tyr Thr Tyr Phe Gln Ala Lys Ile Arg 
                725                 730                 735     


Ala Leu Lys Gly His Ala Gly His Pro Ala Ala 
            740                 745         


<210>  3
<211>  2583
<212>  DNA
<213>  Homo sapiens

<400>  3
ggaggcaggc ggtgccgcgg cgccgggacc cgactcatcc ggtgcttgcg tgtggtggtg     60

agcgcagcgc cgaggatgag gaggtgcaac agcggctccg ggccgccgcc gtcgctgctg    120

ctgctgctgc tgtggctgct cgcggttccc ggcgctaacg cggccccgcg gtcggcgctc    180

tattcgcctt ccgacccgct gacgctgctg caggcggaca cggtgcgcgg cgcggtgctg    240

ggctcccgca gcgcctgggc cgtggagttc ttcgcctcct ggtgcggcca ctgcatcgcc    300

ttcgccccga cgtggaaggc gctggccgaa gacgtcaaag cctggaggcc ggccctgtat    360

ctcgccgccc tggactgtgc tgaggagacc aacagtgcag tctgcagaga cttcaacatc    420

cctggcttcc cgactgtgag gttcttcaag gcctttacca agaacggctc gggagcagta    480

tttccagtgg ctggtgctga cgtgcagaca ctgcgggaga ggctcattga cgccctggag    540

tcccatcatg acacgtggcc cccagcctgt cccccactgg agcctgccaa gctggaggag    600

attgatggat tctttgcgag aaataacgaa gagtacctgg ctctgatctt tgaaaaggga    660

ggctcctacc tgggtagaga ggtggctctg gacctgtccc agcacaaagg cgtggcggtg    720

cgcagggtgc tgaacacaga ggccaatgtg gtgagaaagt ttggtgtcac cgacttcccc    780

tcttgctacc tgctgttccg gaatggctct gtctcccgag tccccgtgct catggaatcc    840

aggtccttct ataccgctta cctgcagaga ctctctgggc tcaccaggga ggctgcccag    900

accacagttg caccaaccac tgctaacaag atagctccca ctgtttggaa attggcagat    960

cgctccaaga tctacatggc tgacctggaa tctgcactgc actacatcct gcggatagaa   1020

gtgggcaggt tcccggtcct ggaagggcag cgcctggtgg ccctgaaaaa gtttgtggca   1080

gtgctggcca agtatttccc tggccggccc ttagtccaga acttcctgca ctccgtgaat   1140

gaatggctca agaggcagaa gagaaataaa attccctaca gtttctttaa aactgccctg   1200

gacgacagga aagagggtgc cgttcttgcc aagaaggtga actggattgg ctgccagggg   1260

agtgagccgc atttccgggg ctttccctgc tccctgtggg tcctcttcca cttcttgact   1320

gtgcaggcag ctcggcaaaa tgtagaccac tcacaggaag cagccaaggc caaggaggtc   1380

ctcccagcca tccgaggcta cgtgcactac ttcttcggct gccgagactg cgctagccac   1440

ttcgagcaga tggctgctgc ctccatgcac cgggtgggga gtcccaacgc cgctgtcctc   1500

tggctctggt ctagccacaa cagggtcaat gctcgccttg caggtgcccc cagcgaggac   1560

ccccagttcc ccaaggtgca gtggccaccc cgtgaacttt gttctgcctg ccacaatgaa   1620

cgcctggatg tgcccgtgtg ggacgtggaa gccaccctca acttcctcaa ggcccacttc   1680

tccccaagca acatcatcct ggacttccct gcagctgggt cagctgcccg gagggatgtg   1740

cagaatgtgg cagccgcccc agagctggcg atgggagccc tggagctgga aagccggaat   1800

tcaactctgg accctgggaa gcctgagatg atgaagtccc ccacaaacac caccccacat   1860

gtgccggctg agggacctga gcttatttga agtcctgcct cattctcact ggagcctcag   1920

tctctcctgc ttggtcttgg ccctcaactg gggcaagtga agccagagga gggtccccca   1980

gctgggtggg ctggaatgga actcctcact agctgctggg gctccgccca ccctgctccc   2040

ttccggacaa tgaagaagcc tttgcaccct gggaggaagg accaccccgg gccctctatg   2100

cctggccagc ctccagctcc tcagacctcc tgggtggggt ttggcttcag ggtggggttt   2160

ggaagcttct ggaagtcgtg ctggtctccc aggtgaggca agccatggtt gctgggctgt   2220

agggtgagtg gcttgcttgg tgggacctga cgagttggtg gcatgggaag gatgtgggtc   2280

tctagtgcct tgccctggct tagctgcagg agaagatggc tgctttcact tccccccatt   2340

gagctctgct ccctctgagc ctggtctttt gtcctttttt attttggtct ccaagatgaa   2400

tgctcatctt tggagggtgc caggtagaag ctagggaggg gagtgtcttc tctctccagg   2460

tttcaccttc cagtgtgcag aagttagaag ggtctggcgg gggcagtgcc ttacacatgc   2520

ttgattccca cgctaccccc tgccttggga ggtgtgtgga ataaattatt tttgttaagg   2580

caa                                                                 2583


<210>  4
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Arg Cys Asn Ser Gly Ser Gly Pro Pro Pro Ser Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Ala Val Pro Gly Ala Asn Ala Ala Pro Arg 
            20                  25                  30          


Ser Ala Leu Tyr Ser Pro Ser Asp Pro Leu Thr Leu Leu Gln Ala Asp 
        35                  40                  45              


Thr Val Arg Gly Ala Val Leu Gly Ser Arg Ser Ala Trp Ala Val Glu 
    50                  55                  60                  


Phe Phe Ala Ser Trp Cys Gly His Cys Ile Ala Phe Ala Pro Thr Trp 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Asp Val Lys Ala Trp Arg Pro Ala Leu Tyr Leu 
                85                  90                  95      


Ala Ala Leu Asp Cys Ala Glu Glu Thr Asn Ser Ala Val Cys Arg Asp 
            100                 105                 110         


Phe Asn Ile Pro Gly Phe Pro Thr Val Arg Phe Phe Lys Ala Phe Thr 
        115                 120                 125             


Lys Asn Gly Ser Gly Ala Val Phe Pro Val Ala Gly Ala Asp Val Gln 
    130                 135                 140                 


Thr Leu Arg Glu Arg Leu Ile Asp Ala Leu Glu Ser His His Asp Thr 
145                 150                 155                 160 


Trp Pro Pro Ala Cys Pro Pro Leu Glu Pro Ala Lys Leu Glu Glu Ile 
                165                 170                 175     


Asp Gly Phe Phe Ala Arg Asn Asn Glu Glu Tyr Leu Ala Leu Ile Phe 
            180                 185                 190         


Glu Lys Gly Gly Ser Tyr Leu Gly Arg Glu Val Ala Leu Asp Leu Ser 
        195                 200                 205             


Gln His Lys Gly Val Ala Val Arg Arg Val Leu Asn Thr Glu Ala Asn 
    210                 215                 220                 


Val Val Arg Lys Phe Gly Val Thr Asp Phe Pro Ser Cys Tyr Leu Leu 
225                 230                 235                 240 


Phe Arg Asn Gly Ser Val Ser Arg Val Pro Val Leu Met Glu Ser Arg 
                245                 250                 255     


Ser Phe Tyr Thr Ala Tyr Leu Gln Arg Leu Ser Gly Leu Thr Arg Glu 
            260                 265                 270         


Ala Ala Gln Thr Thr Val Ala Pro Thr Thr Ala Asn Lys Ile Ala Pro 
        275                 280                 285             


Thr Val Trp Lys Leu Ala Asp Arg Ser Lys Ile Tyr Met Ala Asp Leu 
    290                 295                 300                 


Glu Ser Ala Leu His Tyr Ile Leu Arg Ile Glu Val Gly Arg Phe Pro 
305                 310                 315                 320 


Val Leu Glu Gly Gln Arg Leu Val Ala Leu Lys Lys Phe Val Ala Val 
                325                 330                 335     


Leu Ala Lys Tyr Phe Pro Gly Arg Pro Leu Val Gln Asn Phe Leu His 
            340                 345                 350         


Ser Val Asn Glu Trp Leu Lys Arg Gln Lys Arg Asn Lys Ile Pro Tyr 
        355                 360                 365             


Ser Phe Phe Lys Thr Ala Leu Asp Asp Arg Lys Glu Gly Ala Val Leu 
    370                 375                 380                 


Ala Lys Lys Val Asn Trp Ile Gly Cys Gln Gly Ser Glu Pro His Phe 
385                 390                 395                 400 


Arg Gly Phe Pro Cys Ser Leu Trp Val Leu Phe His Phe Leu Thr Val 
                405                 410                 415     


Gln Ala Ala Arg Gln Asn Val Asp His Ser Gln Glu Ala Ala Lys Ala 
            420                 425                 430         


Lys Glu Val Leu Pro Ala Ile Arg Gly Tyr Val His Tyr Phe Phe Gly 
        435                 440                 445             


Cys Arg Asp Cys Ala Ser His Phe Glu Gln Met Ala Ala Ala Ser Met 
    450                 455                 460                 


His Arg Val Gly Ser Pro Asn Ala Ala Val Leu Trp Leu Trp Ser Ser 
465                 470                 475                 480 


His Asn Arg Val Asn Ala Arg Leu Ala Gly Ala Pro Ser Glu Asp Pro 
                485                 490                 495     


Gln Phe Pro Lys Val Gln Trp Pro Pro Arg Glu Leu Cys Ser Ala Cys 
            500                 505                 510         


His Asn Glu Arg Leu Asp Val Pro Val Trp Asp Val Glu Ala Thr Leu 
        515                 520                 525             


Asn Phe Leu Lys Ala His Phe Ser Pro Ser Asn Ile Ile Leu Asp Phe 
    530                 535                 540                 


Pro Ala Ala Gly Ser Ala Ala Arg Arg Asp Val Gln Asn Val Ala Ala 
545                 550                 555                 560 


Ala Pro Glu Leu Ala Met Gly Ala Leu Glu Leu Glu Ser Arg Asn Ser 
                565                 570                 575     


Thr Leu Asp Pro Gly Lys Pro Glu Met Met Lys Ser Pro Thr Asn Thr 
            580                 585                 590         


Thr Pro His Val Pro Ala Glu Gly Pro Glu Leu Ile 
        595                 600                 


<210>  5
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Ala Gly Ala Pro Ser Glu Asp Pro Gln Phe Pro Lys 
1               5                   10              


