                         SEQUENCE LISTING

<110>  Fondazione Telethon
       Fondazione Salvatore Maugeri Clinica del Lavoro e della 
       Riabilitazione
       BONETTO, Valentina
       BENDOTTI, Caterina
       MORA, Gabriele
       CORBO, Massimo
 
<120>  MULTIPROTEIN BIOMARKERS OF AMYOTROPHIC LATERAL SCLEROSIS IN 
       PERIPHERAL BLOOD MONONUCLEAR  CELLS, DIAGNOSTIC METHODS AND KITS

<130>  PCT 114064

<150>  US 61/361,730
<151>  2010-07-06

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Gly Phe Val Gly Arg Val Ala Ala Ala Pro Ala Ser Gly Ala 
1               5                   10                  15      


Leu Arg Arg Leu Thr Pro Ser Ala Ser Leu Pro Pro Ala Gln Leu Leu 
            20                  25                  30          


Leu Arg Ala Ala Pro Thr Ala Val His Pro Val Arg Asp Tyr Ala Ala 
        35                  40                  45              


Gln Thr Ser Pro Ser Pro Lys Ala Gly Ala Ala Thr Gly Arg Ile Val 
    50                  55                  60                  


Ala Val Ile Gly Ala Val Val Asp Val Gln Phe Asp Glu Gly Leu Pro 
65                  70                  75                  80  


Pro Ile Leu Asn Ala Leu Glu Val Gln Gly Arg Glu Thr Arg Leu Val 
                85                  90                  95      


Leu Glu Val Ala Gln His Leu Gly Glu Ser Thr Val Arg Thr Ile Ala 
            100                 105                 110         


Met Asp Gly Thr Glu Gly Leu Val Arg Gly Gln Lys Val Leu Asp Ser 
        115                 120                 125             


Gly Ala Pro Ile Lys Ile Pro Val Gly Pro Glu Thr Leu Gly Arg Ile 
    130                 135                 140                 


Met Asn Val Ile Gly Glu Pro Ile Asp Glu Arg Gly Pro Ile Lys Thr 
145                 150                 155                 160 


Lys Gln Phe Ala Pro Ile His Ala Glu Ala Pro Glu Phe Met Glu Met 
                165                 170                 175     


Ser Val Glu Gln Glu Ile Leu Val Thr Gly Ile Lys Val Val Asp Leu 
            180                 185                 190         


Leu Ala Pro Tyr Ala Lys Gly Gly Lys Ile Gly Leu Phe Gly Gly Ala 
        195                 200                 205             


Gly Val Gly Lys Thr Val Leu Ile Met Glu Leu Ile Asn Asn Val Ala 
    210                 215                 220                 


Lys Ala His Gly Gly Tyr Ser Val Phe Ala Gly Val Gly Glu Arg Thr 
225                 230                 235                 240 


Arg Glu Gly Asn Asp Leu Tyr His Glu Met Ile Glu Ser Gly Val Ile 
                245                 250                 255     


Asn Leu Lys Asp Ala Thr Ser Lys Val Ala Leu Val Tyr Gly Gln Met 
            260                 265                 270         


Asn Glu Pro Pro Gly Ala Arg Ala Arg Val Ala Leu Thr Gly Leu Thr 
        275                 280                 285             


Val Ala Glu Tyr Phe Arg Asp Gln Glu Gly Gln Asp Val Leu Leu Phe 
    290                 295                 300                 


Ile Asp Asn Ile Phe Arg Phe Thr Gln Ala Gly Ser Glu Val Ser Ala 
305                 310                 315                 320 


Leu Leu Gly Arg Ile Pro Ser Ala Val Gly Tyr Gln Pro Thr Leu Ala 
                325                 330                 335     


Thr Asp Met Gly Thr Met Gln Glu Arg Ile Thr Thr Thr Lys Lys Gly 
            340                 345                 350         


Ser Ile Thr Ser Val Gln Ala Ile Tyr Val Pro Ala Asp Asp Leu Thr 
        355                 360                 365             


Asp Pro Ala Pro Ala Thr Thr Phe Ala His Leu Asp Ala Thr Thr Val 
    370                 375                 380                 


Leu Ser Arg Ala Ile Ala Glu Leu Gly Ile Tyr Pro Ala Val Asp Pro 
385                 390                 395                 400 


Leu Asp Ser Thr Ser Arg Ile Met Asp Pro Asn Ile Val Gly Ser Glu 
                405                 410                 415     


His Tyr Asp Val Ala Arg Gly Val Gln Lys Ile Leu Gln Asp Tyr Lys 
            420                 425                 430         


Ser Leu Gln Asp Ile Ile Ala Ile Leu Gly Met Asp Glu Leu Ser Glu 
        435                 440                 445             


Glu Asp Lys Leu Thr Val Ser Arg Ala Arg Lys Ile Gln Arg Phe Leu 
    450                 455                 460                 


Ser Gln Pro Phe Gln Val Ala Glu Val Phe Thr Gly His Met Gly Lys 
465                 470                 475                 480 


Leu Val Pro Leu Lys Glu Thr Ile Lys Gly Phe Gln Gln Ile Leu Ala 
                485                 490                 495     


Gly Glu Tyr Asp His Leu Pro Glu Gln Ala Phe Tyr Met Val Gly Pro 
            500                 505                 510         


Ile Glu Glu Ala Val Ala Lys Ala Asp Lys Leu Ala Glu Glu His Ser 
        515                 520                 525             


Ser 
    


<210>  2
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly Asn Trp Lys Met Asn 
1               5                   10                  15      


Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala 
            20                  25                  30          


Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala Pro Pro Thr Ala Tyr 
        35                  40                  45              


Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys Ile Ala Val Ala Ala 
    50                  55                  60                  


Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe Thr Gly Glu Ile Ser 
65                  70                  75                  80  


Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp Val Val Leu Gly His 
                85                  90                  95      


Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp Glu Leu Ile Gly Gln 
            100                 105                 110         


Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly Val Ile Ala Cys Ile 
        115                 120                 125             


Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile Thr Glu Lys Val Val 
    130                 135                 140                 


Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val Lys Asp Trp Ser Lys 
145                 150                 155                 160 


Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile Gly Thr Gly Lys Thr 
                165                 170                 175     


Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu Lys Leu Arg Gly Trp 
            180                 185                 190         


Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln Ser Thr Arg Ile Ile 
        195                 200                 205             


Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys Glu Leu Ala Ser Gln 
    210                 215                 220                 


Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Phe Val Asp Ile Ile Asn Ala Lys Gln 
                245                 


<210>  3
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Leu Ser Asn Lys Leu Thr Leu Asp Lys Leu Asp Val Lys Gly 
1               5                   10                  15      


Lys Arg Val Val Met Arg Val Asp Phe Asn Val Pro Met Lys Asn Asn 
            20                  25                  30          


Gln Ile Thr Asn Asn Gln Arg Ile Lys Ala Ala Val Pro Ser Ile Lys 
        35                  40                  45              


Phe Cys Leu Asp Asn Gly Ala Lys Ser Val Val Leu Met Ser His Leu 
    50                  55                  60                  


Gly Arg Pro Asp Gly Val Pro Met Pro Asp Lys Tyr Ser Leu Glu Pro 
65                  70                  75                  80  


Val Ala Val Glu Leu Lys Ser Leu Leu Gly Lys Asp Val Leu Phe Leu 
                85                  90                  95      


Lys Asp Cys Val Gly Pro Glu Val Glu Lys Ala Cys Ala Asn Pro Ala 
            100                 105                 110         


Ala Gly Ser Val Ile Leu Leu Glu Asn Leu Arg Phe His Val Glu Glu 
        115                 120                 125             


Glu Gly Lys Gly Lys Asp Ala Ser Gly Asn Lys Val Lys Ala Glu Pro 
    130                 135                 140                 


Ala Lys Ile Glu Ala Phe Arg Ala Ser Leu Ser Lys Leu Gly Asp Val 
145                 150                 155                 160 


Tyr Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ser Ser Met 
                165                 170                 175     


Val Gly Val Asn Leu Pro Gln Lys Ala Gly Gly Phe Leu Met Lys Lys 
            180                 185                 190         


Glu Leu Asn Tyr Phe Ala Lys Ala Leu Glu Ser Pro Glu Arg Pro Phe 
        195                 200                 205             


Leu Ala Ile Leu Gly Gly Ala Lys Val Ala Asp Lys Ile Gln Leu Ile 
    210                 215                 220                 


Asn Asn Met Leu Asp Lys Val Asn Glu Met Ile Ile Gly Gly Gly Met 
225                 230                 235                 240 


Ala Phe Thr Phe Leu Lys Val Leu Asn Asn Met Glu Ile Gly Thr Ser 
                245                 250                 255     


Leu Phe Asp Glu Glu Gly Ala Lys Ile Val Lys Asp Leu Met Ser Lys 
            260                 265                 270         


Ala Glu Lys Asn Gly Val Lys Ile Thr Leu Pro Val Asp Phe Val Thr 
        275                 280                 285             


Ala Asp Lys Phe Asp Glu Asn Ala Lys Thr Gly Gln Ala Thr Val Ala 
    290                 295                 300                 


Ser Gly Ile Pro Ala Gly Trp Met Gly Leu Asp Cys Gly Pro Glu Ser 
305                 310                 315                 320 


Ser Lys Lys Tyr Ala Glu Ala Val Thr Arg Ala Lys Gln Ile Val Trp 
                325                 330                 335     


Asn Gly Pro Val Gly Val Phe Glu Trp Glu Ala Phe Ala Arg Gly Thr 
            340                 345                 350         


Lys Ala Leu Met Asp Glu Val Val Lys Ala Thr Ser Arg Gly Cys Ile 
        355                 360                 365             


Thr Ile Ile Gly Gly Gly Asp Thr Ala Thr Cys Cys Ala Lys Trp Asn 
    370                 375                 380                 


Thr Glu Asp Lys Val Ser His Val Ser Thr Gly Gly Gly Ala Ser Leu 
385                 390                 395                 400 


Glu Leu Leu Glu Gly Lys Val Leu Pro Gly Val Asp Ala Leu Ser Asn 
                405                 410                 415     


Ile 
    


<210>  4
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Phe Thr Ser Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Tyr Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Thr Glu Gln Glu Lys Ile Asp Lys Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Ser Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ala 
                165                 170                 175     


Asn Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Gly Leu 
    210                 215                 220                 


Glu Leu Leu Lys Thr Ala Ile Gly Lys Ala Gly Tyr Thr Asp Lys Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Phe Arg Ser Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Pro Ser Arg Tyr Ile Ser 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Gly Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Ser Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Val Asn Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ala Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Asn Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  5
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Tyr Gln Tyr Pro Ala Leu Thr Pro Glu Gln Lys Lys Glu Leu 
1               5                   10                  15      


Ser Asp Ile Ala His Arg Ile Val Ala Pro Gly Lys Gly Ile Leu Ala 
            20                  25                  30          


Ala Asp Glu Ser Thr Gly Ser Ile Ala Lys Arg Leu Gln Ser Ile Gly 
        35                  40                  45              


Thr Glu Asn Thr Glu Glu Asn Arg Arg Phe Tyr Arg Gln Leu Leu Leu 
    50                  55                  60                  


Thr Ala Asp Asp Arg Val Asn Pro Cys Ile Gly Gly Val Ile Leu Phe 
65                  70                  75                  80  


His Glu Thr Leu Tyr Gln Lys Ala Asp Asp Gly Arg Pro Phe Pro Gln 
                85                  90                  95      


Val Ile Lys Ser Lys Gly Gly Val Val Gly Ile Lys Val Asp Lys Gly 
            100                 105                 110         


Val Val Pro Leu Ala Gly Thr Asn Gly Glu Thr Thr Thr Gln Gly Leu 
        115                 120                 125             


Asp Gly Leu Ser Glu Arg Cys Ala Gln Tyr Lys Lys Asp Gly Ala Asp 
    130                 135                 140                 


Phe Ala Lys Trp Arg Cys Val Leu Lys Ile Gly Glu His Thr Pro Ser 
145                 150                 155                 160 


Ala Leu Ala Ile Met Glu Asn Ala Asn Val Leu Ala Arg Tyr Ala Ser 
                165                 170                 175     


Ile Cys Gln Gln Asn Gly Ile Val Pro Ile Val Glu Pro Glu Ile Leu 
            180                 185                 190         


Pro Asp Gly Asp His Asp Leu Lys Arg Cys Gln Tyr Val Thr Glu Lys 
        195                 200                 205             


Val Leu Ala Ala Val Tyr Lys Ala Leu Ser Asp His His Ile Tyr Leu 
    210                 215                 220                 


Glu Gly Thr Leu Leu Lys Pro Asn Met Val Thr Pro Gly His Ala Cys 
225                 230                 235                 240 


Thr Gln Lys Phe Ser His Glu Glu Ile Ala Met Ala Thr Val Thr Ala 
                245                 250                 255     


Leu Arg Arg Thr Val Pro Pro Ala Val Thr Gly Ile Thr Phe Leu Ser 
            260                 265                 270         


Gly Gly Gln Ser Glu Glu Glu Ala Ser Ile Asn Leu Asn Ala Ile Asn 
        275                 280                 285             


Lys Cys Pro Leu Leu Lys Pro Trp Ala Leu Thr Phe Ser Tyr Gly Arg 
    290                 295                 300                 


Ala Leu Gln Ala Ser Ala Leu Lys Ala Trp Gly Gly Lys Lys Glu Asn 
305                 310                 315                 320 


Leu Lys Ala Ala Gln Glu Glu Tyr Val Lys Arg Ala Leu Ala Asn Ser 
                325                 330                 335     


Leu Ala Cys Gln Gly Lys Tyr Thr Pro Ser Gly Gln Ala Gly Ala Ala 
            340                 345                 350         


Ala Ser Glu Ser Leu Phe Val Ser Asn His Ala Tyr 
        355                 360                 


<210>  6
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Lys Val Lys Val Gly Val Asn Gly Phe Gly Arg Ile Gly Arg 
1               5                   10                  15      


Leu Val Thr Arg Ala Ala Phe Asn Ser Gly Lys Val Asp Ile Val Ala 
            20                  25                  30          


Ile Asn Asp Pro Phe Ile Asp Leu Asn Tyr Met Val Tyr Met Phe Gln 
        35                  40                  45              


Tyr Asp Ser Thr His Gly Lys Phe His Gly Thr Val Lys Ala Glu Asn 
    50                  55                  60                  


Gly Lys Leu Val Ile Asn Gly Asn Pro Ile Thr Ile Phe Gln Glu Arg 
65                  70                  75                  80  


Asp Pro Ser Lys Ile Lys Trp Gly Asp Ala Gly Ala Glu Tyr Val Val 
                85                  90                  95      


Glu Ser Thr Gly Val Phe Thr Thr Met Glu Lys Ala Gly Ala His Leu 
            100                 105                 110         


Gln Gly Gly Ala Lys Arg Val Ile Ile Ser Ala Pro Ser Ala Asp Ala 
        115                 120                 125             


Pro Met Phe Val Met Gly Val Asn His Glu Lys Tyr Asp Asn Ser Leu 
    130                 135                 140                 


Lys Ile Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Leu 
145                 150                 155                 160 


Ala Lys Val Ile His Asp Asn Phe Gly Ile Val Glu Gly Leu Met Thr 
                165                 170                 175     


Thr Val His Ala Ile Thr Ala Thr Gln Lys Thr Val Asp Gly Pro Ser 
            180                 185                 190         


Gly Lys Leu Trp Arg Asp Gly Arg Gly Ala Leu Gln Asn Ile Ile Pro 
        195                 200                 205             


Ala Ser Thr Gly Ala Ala Lys Ala Val Gly Lys Val Ile Pro Glu Leu 
    210                 215                 220                 


Asn Gly Lys Leu Thr Gly Met Ala Phe Arg Val Pro Thr Ala Asn Val 
225                 230                 235                 240 


Ser Val Val Asp Leu Thr Cys Arg Leu Glu Lys Pro Ala Lys Tyr Asp 
                245                 250                 255     


Asp Ile Lys Lys Val Val Lys Gln Ala Ser Glu Gly Pro Leu Lys Gly 
            260                 265                 270         


Ile Leu Gly Tyr Thr Glu His Gln Val Val Ser Ser Asp Phe Asn Ser 
        275                 280                 285             


Asp Thr His Ser Ser Thr Phe Asp Ala Gly Ala Gly Ile Ala Leu Asn 
    290                 295                 300                 


Asp His Phe Val Lys Leu Ile Ser Trp Tyr Asp Asn Glu Phe Gly Tyr 
305                 310                 315                 320 


Ser Asn Arg Val Val Asp Leu Met Ala His Met Ala Ser Lys Glu 
                325                 330                 335 


<210>  7
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu 
1               5                   10                  15      


Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly 
            20                  25                  30          


Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu 
        35                  40                  45              


Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp 
    50                  55                  60                  


Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly 
65                  70                  75                  80  


Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala 
                85                  90                  95      


Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg 
            100                 105                 110         


Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser 
        115                 120                 125             


Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr 
    130                 135                 140                 


Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly 
145                 150                 155                 160 


Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu 
                165                 170                 175     


Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu 
            180                 185                 190         


His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly 
        195                 200                 205             


Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys 
    210                 215                 220                 


Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Ser Ala Tyr Glu 
225                 230                 235                 240 


Val Ile Lys Leu Lys Gly Tyr Thr Ser Trp Ala Ile Gly Leu Ser Val 
                245                 250                 255     


Ala Asp Leu Ala Glu Ser Ile Met Lys Asn Leu Arg Arg Val His Pro 
            260                 265                 270         


Val Ser Thr Met Ile Lys Gly Leu Tyr Gly Ile Lys Asp Asp Val Phe 
        275                 280                 285             


Leu Ser Val Pro Cys Ile Leu Gly Gln Asn Gly Ile Ser Asp Leu Val 
    290                 295                 300                 


Lys Val Thr Leu Thr Ser Glu Glu Glu Ala Arg Leu Lys Lys Ser Ala 
305                 310                 315                 320 


Asp Thr Leu Trp Gly Ile Gln Lys Glu Leu Gln Phe 
                325                 330         


<210>  8
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Thr Leu Lys Glu Lys Leu Ile Ala Pro Val Ala Glu Glu Glu 
1               5                   10                  15      


Ala Thr Val Pro Asn Asn Lys Ile Thr Val Val Gly Val Gly Gln Val 
            20                  25                  30          


Gly Met Ala Cys Ala Ile Ser Ile Leu Gly Lys Ser Leu Ala Asp Glu 
        35                  40                  45              


Leu Ala Leu Val Asp Val Leu Glu Asp Lys Leu Lys Gly Glu Met Met 
    50                  55                  60                  


Asp Leu Gln His Gly Ser Leu Phe Leu Gln Thr Pro Lys Ile Val Ala 
65                  70                  75                  80  


Asp Lys Asp Tyr Ser Val Thr Ala Asn Ser Lys Ile Val Val Val Thr 
                85                  90                  95      


Ala Gly Val Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln 
            100                 105                 110         


Arg Asn Val Asn Val Phe Lys Phe Ile Ile Pro Gln Ile Val Lys Tyr 
        115                 120                 125             


Ser Pro Asp Cys Ile Ile Ile Val Val Ser Asn Pro Val Asp Ile Leu 
    130                 135                 140                 


Thr Tyr Val Thr Trp Lys Leu Ser Gly Leu Pro Lys His Arg Val Ile 
145                 150                 155                 160 


Gly Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Ala 
                165                 170                 175     


Glu Lys Leu Gly Ile His Pro Ser Ser Cys His Gly Trp Ile Leu Gly 
            180                 185                 190         


Glu His Gly Asp Ser Ser Val Ala Val Trp Ser Gly Val Asn Val Ala 
        195                 200                 205             


Gly Val Ser Leu Gln Glu Leu Asn Pro Glu Met Gly Thr Asp Asn Asp 
    210                 215                 220                 


Ser Glu Asn Trp Lys Glu Val His Lys Met Val Val Glu Ser Ala Tyr 
225                 230                 235                 240 


Glu Val Ile Lys Leu Lys Gly Tyr Thr Asn Trp Ala Ile Gly Leu Ser 
                245                 250                 255     


Val Ala Asp Leu Ile Glu Ser Met Leu Lys Asn Leu Ser Arg Ile His 
            260                 265                 270         


Pro Val Ser Thr Met Val Lys Gly Met Tyr Gly Ile Glu Asn Glu Val 
        275                 280                 285             


Phe Leu Ser Leu Pro Cys Ile Leu Asn Ala Arg Gly Leu Thr Ser Val 
    290                 295                 300                 


Ile Asn Gln Lys Leu Lys Asp Asp Glu Val Ala Gln Leu Lys Lys Ser 
305                 310                 315                 320 


Ala Asp Thr Leu Trp Asp Ile Gln Lys Asp Leu Lys Asp Leu 
                325                 330                 


<210>  9
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala 
            100                 105                 110         


Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val 
        115                 120                 125             


Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu 
    130                 135                 140                 


Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr 
145                 150                 155                 160 


Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile 
                165                 170                 175     


Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp 
            180                 185                 190         


Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln 
        195                 200                 205     


<210>  10
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ser Gly Asn Ala Arg Ile Gly Lys Pro Ala Pro Asp Phe Lys 
1               5                   10                  15      


Ala Thr Ala Val Val Asp Gly Ala Phe Lys Glu Val Lys Leu Ser Asp 
            20                  25                  30          


Tyr Lys Gly Lys Tyr Val Val Leu Phe Phe Tyr Pro Leu Asp Phe Thr 
        35                  40                  45              


Phe Val Cys Pro Thr Glu Ile Ile Ala Phe Ser Asn Arg Ala Glu Asp 
    50                  55                  60                  


Phe Arg Lys Leu Gly Cys Glu Val Leu Gly Val Ser Val Asp Ser Gln 
65                  70                  75                  80  


Phe Thr His Leu Ala Trp Ile Asn Thr Pro Arg Lys Glu Gly Gly Leu 
                85                  90                  95      


Gly Pro Leu Asn Ile Pro Leu Leu Ala Asp Val Thr Arg Arg Leu Ser 
            100                 105                 110         


Glu Asp Tyr Gly Val Leu Lys Thr Asp Glu Gly Ile Ala Tyr Arg Gly 
        115                 120                 125             


Leu Phe Ile Ile Asp Gly Lys Gly Val Leu Arg Gln Ile Thr Val Asn 
    130                 135                 140                 


Asp Leu Pro Val Gly Arg Ser Val Asp Glu Ala Leu Arg Leu Val Gln 
145                 150                 155                 160 


Ala Phe Gln Tyr Thr Asp Glu His Gly Glu Val Cys Pro Ala Gly Trp 
                165                 170                 175     


Lys Pro Gly Ser Asp Thr Ile Lys Pro Asn Val Asp Asp Ser Lys Glu 
            180                 185                 190         


Tyr Phe Ser Lys His Asn 
        195             


<210>  11
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  12
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Gly Glu Ser Ala Arg Ser Leu Gly Lys Gly Ser Ala Pro Pro 
1               5                   10                  15      


Gly Pro Val Pro Glu Gly Ser Ile Arg Ile Tyr Ser Met Arg Phe Cys 
            20                  25                  30          


Pro Phe Ala Glu Arg Thr Arg Leu Val Leu Lys Ala Lys Gly Ile Arg 
        35                  40                  45              


His Glu Val Ile Asn Ile Asn Leu Lys Asn Lys Pro Glu Trp Phe Phe 
    50                  55                  60                  


Lys Lys Asn Pro Phe Gly Leu Val Pro Val Leu Glu Asn Ser Gln Gly 
65                  70                  75                  80  


Gln Leu Ile Tyr Glu Ser Ala Ile Thr Cys Glu Tyr Leu Asp Glu Ala 
                85                  90                  95      


Tyr Pro Gly Lys Lys Leu Leu Pro Asp Asp Pro Tyr Glu Lys Ala Cys 
            100                 105                 110         


Gln Lys Met Ile Leu Glu Leu Phe Ser Lys Val Pro Ser Leu Val Gly 
        115                 120                 125             


Ser Phe Ile Arg Ser Gln Asn Lys Glu Asp Tyr Ala Gly Leu Lys Glu 
    130                 135                 140                 


Glu Phe Arg Lys Glu Phe Thr Lys Leu Glu Glu Val Leu Thr Asn Lys 
145                 150                 155                 160 


Lys Thr Thr Phe Phe Gly Gly Asn Ser Ile Ser Met Ile Asp Tyr Leu 
                165                 170                 175     


Ile Trp Pro Trp Phe Glu Arg Leu Glu Ala Met Lys Leu Asn Glu Cys 
            180                 185                 190         


Val Asp His Thr Pro Lys Leu Lys Leu Trp Met Ala Ala Met Lys Glu 
        195                 200                 205             


Asp Pro Thr Val Ser Ala Leu Leu Thr Ser Glu Lys Asp Trp Gln Gly 
    210                 215                 220                 


Phe Leu Glu Leu Tyr Leu Gln Asn Ser Pro Glu Ala Cys Asp Tyr Gly 
225                 230                 235                 240 


Leu 
    


<210>  13
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Ser Arg Ala Val Cys Gly Thr Ser Arg Gln Leu Ala Pro Ala 
1               5                   10                  15      


Leu Gly Tyr Leu Gly Ser Arg Gln Lys His Ser Leu Pro Asp Leu Pro 
            20                  25                  30          


Tyr Asp Tyr Gly Ala Leu Glu Pro His Ile Asn Ala Gln Ile Met Gln 
        35                  40                  45              


Leu His His Ser Lys His His Ala Ala Tyr Val Asn Asn Leu Asn Val 
    50                  55                  60                  


Thr Glu Glu Lys Tyr Gln Glu Ala Leu Ala Lys Gly Asp Val Thr Ala 
65                  70                  75                  80  


Gln Ile Ala Leu Gln Pro Ala Leu Lys Phe Asn Gly Gly Gly His Ile 
                85                  90                  95      


Asn His Ser Ile Phe Trp Thr Asn Leu Ser Pro Asn Gly Gly Gly Glu 
            100                 105                 110         


Pro Lys Gly Glu Leu Leu Glu Ala Ile Lys Arg Asp Phe Gly Ser Phe 
        115                 120                 125             


Asp Lys Phe Lys Glu Lys Leu Thr Ala Ala Ser Val Gly Val Gln Gly 
    130                 135                 140                 


Ser Gly Trp Gly Trp Leu Gly Phe Asn Lys Glu Arg Gly His Leu Gln 
145                 150                 155                 160 


Ile Ala Ala Cys Pro Asn Gln Asp Pro Leu Gln Gly Thr Thr Gly Leu 
                165                 170                 175     


Ile Pro Leu Leu Gly Ile Asp Val Trp Glu His Ala Tyr Tyr Leu Gln 
            180                 185                 190         


Tyr Lys Asn Val Arg Pro Asp Tyr Leu Lys Ala Ile Trp Asn Val Ile 
        195                 200                 205             


Asn Trp Glu Asn Val Thr Glu Arg Tyr Met Ala Cys Lys Lys 
    210                 215                 220         


<210>  14
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Lys Arg Ala Leu Val Ile Leu Ala Lys Gly Ala Glu Glu 
1               5                   10                  15      


Met Glu Thr Val Ile Pro Val Asp Val Met Arg Arg Ala Gly Ile Lys 
            20                  25                  30          


Val Thr Val Ala Gly Leu Ala Gly Lys Asp Pro Val Gln Cys Ser Arg 
        35                  40                  45              


Asp Val Val Ile Cys Pro Asp Ala Ser Leu Glu Asp Ala Lys Lys Glu 
    50                  55                  60                  


Gly Pro Tyr Asp Val Val Val Leu Pro Gly Gly Asn Leu Gly Ala Gln 
65                  70                  75                  80  


Asn Leu Ser Glu Ser Ala Ala Val Lys Glu Ile Leu Lys Glu Gln Glu 
                85                  90                  95      


Asn Arg Lys Gly Leu Ile Ala Ala Ile Cys Ala Gly Pro Thr Ala Leu 
            100                 105                 110         


Leu Ala His Glu Ile Gly Phe Gly Ser Lys Val Thr Thr His Pro Leu 
        115                 120                 125             


Ala Lys Asp Lys Met Met Asn Gly Gly His Tyr Thr Tyr Ser Glu Asn 
    130                 135                 140                 


Arg Val Glu Lys Asp Gly Leu Ile Leu Thr Ser Arg Gly Pro Gly Thr 
145                 150                 155                 160 


Ser Phe Glu Phe Ala Leu Ala Ile Val Glu Ala Leu Asn Gly Lys Glu 
                165                 170                 175     


Val Ala Ala Gln Val Lys Ala Pro Leu Val Leu Lys Asp 
            180                 185                 


<210>  15
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Glu Glu Gln Pro Gln Val Glu Leu Phe Val Lys Ala Gly Ser 
1               5                   10                  15      


Asp Gly Ala Lys Ile Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met 
            20                  25                  30          


Val Leu Trp Leu Lys Gly Val Thr Phe Asn Val Thr Thr Val Asp Thr 
        35                  40                  45              


Lys Arg Arg Thr Glu Thr Val Gln Lys Leu Cys Pro Gly Gly Gln Leu 
    50                  55                  60                  


Pro Phe Leu Leu Tyr Gly Thr Glu Val His Thr Asp Thr Asn Lys Ile 
65                  70                  75                  80  


Glu Glu Phe Leu Glu Ala Val Leu Cys Pro Pro Arg Tyr Pro Lys Leu 
                85                  90                  95      


Ala Ala Leu Asn Pro Glu Ser Asn Thr Ala Gly Leu Asp Ile Phe Ala 
            100                 105                 110         


Lys Phe Ser Ala Tyr Ile Lys Asn Ser Asn Pro Ala Leu Asn Asp Asn 
        115                 120                 125             


Leu Glu Lys Gly Leu Leu Lys Ala Leu Lys Val Leu Asp Asn Tyr Leu 
    130                 135                 140                 


Thr Ser Pro Leu Pro Glu Glu Val Asp Glu Thr Ser Ala Glu Asp Glu 
145                 150                 155                 160 


Gly Val Ser Gln Arg Lys Phe Leu Asp Gly Asn Glu Leu Thr Leu Ala 
                165                 170                 175     


Asp Cys Asn Leu Leu Pro Lys Leu His Ile Val Gln Val Val Cys Lys 
            180                 185                 190         


Lys Tyr Arg Gly Phe Thr Ile Pro Glu Ala Phe Arg Gly Val His Arg 
        195                 200                 205             


Tyr Leu Ser Asn Ala Tyr Ala Arg Glu Glu Phe Ala Ser Thr Cys Pro 
    210                 215                 220                 


Asp Asp Glu Glu Ile Glu Leu Ala Tyr Glu Gln Val Ala Lys Ala Leu 
225                 230                 235                 240 


Lys 
    


<210>  16
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  17
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Ser 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Val Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  18
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  19
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Leu Arg Arg Ala Leu Leu Cys Leu Ala Val Ala Ala Leu Val Arg 
1               5                   10                  15      


Ala Asp Ala Pro Glu Glu Glu Asp His Val Leu Val Leu Arg Lys Ser 
            20                  25                  30          


Asn Phe Ala Glu Ala Leu Ala Ala His Lys Tyr Leu Leu Val Glu Phe 
        35                  40                  45              


Tyr Ala Pro Trp Cys Gly His Cys Lys Ala Leu Ala Pro Glu Tyr Ala 
    50                  55                  60                  


Lys Ala Ala Gly Lys Leu Lys Ala Glu Gly Ser Glu Ile Arg Leu Ala 
65                  70                  75                  80  


Lys Val Asp Ala Thr Glu Glu Ser Asp Leu Ala Gln Gln Tyr Gly Val 
                85                  90                  95      


Arg Gly Tyr Pro Thr Ile Lys Phe Phe Arg Asn Gly Asp Thr Ala Ser 
            100                 105                 110         


Pro Lys Glu Tyr Thr Ala Gly Arg Glu Ala Asp Asp Ile Val Asn Trp 
        115                 120                 125             


Leu Lys Lys Arg Thr Gly Pro Ala Ala Thr Thr Leu Pro Asp Gly Ala 
    130                 135                 140                 


Ala Ala Glu Ser Leu Val Glu Ser Ser Glu Val Ala Val Ile Gly Phe 
145                 150                 155                 160 


Phe Lys Asp Val Glu Ser Asp Ser Ala Lys Gln Phe Leu Gln Ala Ala 
                165                 170                 175     


Glu Ala Ile Asp Asp Ile Pro Phe Gly Ile Thr Ser Asn Ser Asp Val 
            180                 185                 190         


Phe Ser Lys Tyr Gln Leu Asp Lys Asp Gly Val Val Leu Phe Lys Lys 
        195                 200                 205             


Phe Asp Glu Gly Arg Asn Asn Phe Glu Gly Glu Val Thr Lys Glu Asn 
    210                 215                 220                 


Leu Leu Asp Phe Ile Lys His Asn Gln Leu Pro Leu Val Ile Glu Phe 
225                 230                 235                 240 


Thr Glu Gln Thr Ala Pro Lys Ile Phe Gly Gly Glu Ile Lys Thr His 
                245                 250                 255     


Ile Leu Leu Phe Leu Pro Lys Ser Val Ser Asp Tyr Asp Gly Lys Leu 
            260                 265                 270         


Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys Gly Lys Ile Leu Phe 
        275                 280                 285             


Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln Arg Ile Leu Glu Phe 
    290                 295                 300                 


Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val Arg Leu Ile Thr Leu 
305                 310                 315                 320 


Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser Glu Glu Leu Thr Ala 
                325                 330                 335     


Glu Arg Ile Thr Glu Phe Cys His Arg Phe Leu Glu Gly Lys Ile Lys 
            340                 345                 350         


Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp Trp Asp Lys Gln Pro 
        355                 360                 365             


Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp Val Ala Phe Asp Glu 
    370                 375                 380                 


Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro Trp Cys Gly His Cys 
385                 390                 395                 400 


Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly Glu Thr Tyr Lys Asp 
                405                 410                 415     


His Glu Asn Ile Val Ile Ala Lys Met Asp Ser Thr Ala Asn Glu Val 
            420                 425                 430         


Glu Ala Val Lys Val His Ser Phe Pro Thr Leu Lys Phe Phe Pro Ala 
        435                 440                 445             


Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly Glu Arg Thr Leu Asp 
    450                 455                 460                 


Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln Asp Gly Ala Gly Asp 
465                 470                 475                 480 


Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu Glu Pro Asp Met Glu 
                485                 490                 495     


Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu Leu 
            500                 505             


<210>  20
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Leu Arg Arg Leu Ala Leu Phe Pro Gly Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Arg Leu Ala Ala Ala Ser Asp Val Leu Glu Leu Thr Asp 
            20                  25                  30          


Asp Asn Phe Glu Ser Arg Ile Ser Asp Thr Gly Ser Ala Gly Leu Met 
        35                  40                  45              


Leu Val Glu Phe Phe Ala Pro Trp Cys Gly His Cys Lys Arg Leu Ala 
    50                  55                  60                  


Pro Glu Tyr Glu Ala Ala Ala Thr Arg Leu Lys Gly Ile Val Pro Leu 
65                  70                  75                  80  


Ala Lys Val Asp Cys Thr Ala Asn Thr Asn Thr Cys Asn Lys Tyr Gly 
                85                  90                  95      


Val Ser Gly Tyr Pro Thr Leu Lys Ile Phe Arg Asp Gly Glu Glu Ala 
            100                 105                 110         


Gly Ala Tyr Asp Gly Pro Arg Thr Ala Asp Gly Ile Val Ser His Leu 
        115                 120                 125             


Lys Lys Gln Ala Gly Pro Ala Ser Val Pro Leu Arg Thr Glu Glu Glu 
    130                 135                 140                 


Phe Lys Lys Phe Ile Ser Asp Lys Asp Ala Ser Ile Val Gly Phe Phe 
145                 150                 155                 160 


Asp Asp Ser Phe Ser Glu Ala His Ser Glu Phe Leu Lys Ala Ala Ser 
                165                 170                 175     


Asn Leu Arg Asp Asn Tyr Arg Phe Ala His Thr Asn Val Glu Ser Leu 
            180                 185                 190         


Val Asn Glu Tyr Asp Asp Asn Gly Glu Gly Ile Ile Leu Phe Arg Pro 
        195                 200                 205             


Ser His Leu Thr Asn Lys Phe Glu Asp Lys Thr Val Ala Tyr Thr Glu 
    210                 215                 220                 


Gln Lys Met Thr Ser Gly Lys Ile Lys Lys Phe Ile Gln Glu Asn Ile 
225                 230                 235                 240 


Phe Gly Ile Cys Pro His Met Thr Glu Asp Asn Lys Asp Leu Ile Gln 
                245                 250                 255     


Gly Lys Asp Leu Leu Ile Ala Tyr Tyr Asp Val Asp Tyr Glu Lys Asn 
            260                 265                 270         


Ala Lys Gly Ser Asn Tyr Trp Arg Asn Arg Val Met Met Val Ala Lys 
        275                 280                 285             


Lys Phe Leu Asp Ala Gly His Lys Leu Asn Phe Ala Val Ala Ser Arg 
    290                 295                 300                 


Lys Thr Phe Ser His Glu Leu Ser Asp Phe Gly Leu Glu Ser Thr Ala 
305                 310                 315                 320 


Gly Glu Ile Pro Val Val Ala Ile Arg Thr Ala Lys Gly Glu Lys Phe 
                325                 330                 335     


Val Met Gln Glu Glu Phe Ser Arg Asp Gly Lys Ala Leu Glu Arg Phe 
            340                 345                 350         


Leu Gln Asp Tyr Phe Asp Gly Asn Leu Lys Arg Tyr Leu Lys Ser Glu 
        355                 360                 365             


Pro Ile Pro Glu Ser Asn Asp Gly Pro Val Lys Val Val Val Ala Glu 
    370                 375                 380                 


Asn Phe Asp Glu Ile Val Asn Asn Glu Asn Lys Asp Val Leu Ile Glu 
385                 390                 395                 400 


Phe Tyr Ala Pro Trp Cys Gly His Cys Lys Asn Leu Glu Pro Lys Tyr 
                405                 410                 415     


Lys Glu Leu Gly Glu Lys Leu Ser Lys Asp Pro Asn Ile Val Ile Ala 
            420                 425                 430         


Lys Met Asp Ala Thr Ala Asn Asp Val Pro Ser Pro Tyr Glu Val Arg 
        435                 440                 445             


Gly Phe Pro Thr Ile Tyr Phe Ser Pro Ala Asn Lys Lys Leu Asn Pro 
    450                 455                 460                 


Lys Lys Tyr Glu Gly Gly Arg Glu Leu Ser Asp Phe Ile Ser Tyr Leu 
465                 470                 475                 480 


Gln Arg Glu Ala Thr Asn Pro Pro Val Ile Gln Glu Glu Lys Pro Lys 
                485                 490                 495     


Lys Lys Lys Lys Ala Gln Glu Asp Leu 
            500                 505 


<210>  21
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ala Ala Val Pro Arg Ala Ala Phe Leu Ser Pro Leu Leu Pro 
1               5                   10                  15      


Leu Leu Leu Gly Phe Leu Leu Leu Ser Ala Pro His Gly Gly Ser Gly 
            20                  25                  30          


Leu His Thr Lys Gly Ala Leu Pro Leu Asp Thr Val Thr Phe Tyr Lys 
        35                  40                  45              


Val Ile Pro Lys Ser Lys Phe Val Leu Val Lys Phe Asp Thr Gln Tyr 
    50                  55                  60                  


Pro Tyr Gly Glu Lys Gln Asp Glu Phe Lys Arg Leu Ala Glu Asn Ser 
65                  70                  75                  80  


Ala Ser Ser Asp Asp Leu Leu Val Ala Glu Val Gly Ile Ser Asp Tyr 
                85                  90                  95      


Gly Asp Lys Leu Asn Met Glu Leu Ser Glu Lys Tyr Lys Leu Asp Lys 
            100                 105                 110         


Glu Ser Tyr Pro Val Phe Tyr Leu Phe Arg Asp Gly Asp Phe Glu Asn 
        115                 120                 125             


Pro Val Pro Tyr Thr Gly Ala Val Lys Val Gly Ala Ile Gln Arg Trp 
    130                 135                 140                 


Leu Lys Gly Gln Gly Val Tyr Leu Gly Met Pro Gly Cys Leu Pro Val 
145                 150                 155                 160 


Tyr Asp Ala Leu Ala Gly Glu Phe Ile Arg Ala Ser Gly Val Glu Ala 
                165                 170                 175     


Arg Gln Ala Leu Leu Lys Gln Gly Gln Asp Asn Leu Ser Ser Val Lys 
            180                 185                 190         


Glu Thr Gln Lys Lys Trp Ala Glu Gln Tyr Leu Lys Ile Met Gly Lys 
        195                 200                 205             


Ile Leu Asp Gln Gly Glu Asp Phe Pro Ala Ser Glu Met Thr Arg Ile 
    210                 215                 220                 


Ala Arg Leu Ile Glu Lys Asn Lys Met Ser Asp Gly Lys Lys Glu Glu 
225                 230                 235                 240 


Leu Gln Lys Ser Leu Asn Ile Leu Thr Ala Phe Gln Lys Lys Gly Ala 
                245                 250                 255     


Glu Lys Glu Glu Leu 
            260     


<210>  22
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  23
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Met Leu Arg Val Gln Pro Glu Ala Gln Ala Lys Val Asp Val 
1               5                   10                  15      


Phe Arg Glu Asp Leu Cys Thr Lys Thr Glu Asn Leu Leu Gly Ser Tyr 
            20                  25                  30          


Phe Pro Lys Lys Ile Ser Glu Leu Asp Ala Phe Leu Lys Glu Pro Ala 
        35                  40                  45              


Leu Asn Glu Ala Asn Leu Ser Asn Leu Lys Ala Pro Leu Asp Ile Pro 
    50                  55                  60                  


Val Pro Asp Pro Val Lys Glu Lys Glu Lys Glu Glu Arg Lys Lys Gln 
65                  70                  75                  80  


Gln Glu Lys Glu Asp Lys Asp Glu Lys Lys Lys Gly Glu Asp Glu Asp 
                85                  90                  95      


Lys Gly Pro Pro Cys Gly Pro Val Asn Cys Asn Glu Lys Ile Val Val 
            100                 105                 110         


Leu Leu Gln Arg Leu Lys Pro Glu Ile Lys Asp Val Ile Glu Gln Leu 
        115                 120                 125             


Asn Leu Val Thr Thr Trp Leu Gln Leu Gln Ile Pro Arg Ile Glu Asp 
    130                 135                 140                 


Gly Asn Asn Phe Gly Val Ala Val Gln Glu Lys Val Phe Glu Leu Met 
145                 150                 155                 160 


Thr Ser Leu His Thr Lys Leu Glu Gly Phe His Thr Gln Ile Ser Lys 
                165                 170                 175     


Tyr Phe Ser Glu Arg Gly Asp Ala Val Thr Lys Ala Ala Lys Gln Pro 
            180                 185                 190         


His Val Gly Asp Tyr Arg Gln Leu Val His Glu Leu Asp Glu Ala Glu 
        195                 200                 205             


Tyr Arg Asp Ile Arg Leu Met Val Met Glu Ile Arg Asn Ala Tyr Ala 
    210                 215                 220                 


Val Leu Tyr Asp Ile Ile Leu Lys Asn Phe Glu Lys Leu Lys Lys Pro 
225                 230                 235                 240 


Arg Gly Glu Thr Lys Gly Met Ile Tyr 
                245                 


<210>  24
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  25
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Val Phe His Thr Arg Thr Ile Glu Ser Ile Leu Glu Pro Val 
1               5                   10                  15      


Ala Gln Gln Ile Ser His Leu Val Ile Met His Glu Glu Gly Glu Val 
            20                  25                  30          


Asp Gly Lys Ala Ile Pro Asp Leu Thr Ala Pro Val Ala Ala Val Gln 
        35                  40                  45              


Ala Ala Val Ser Asn Leu Val Arg Val Gly Lys Glu Thr Val Gln Thr 
    50                  55                  60                  


Thr Glu Asp Gln Ile Leu Lys Arg Asp Met Pro Pro Ala Phe Ile Lys 
65                  70                  75                  80  


Val Glu Asn Ala Cys Thr Lys Leu Val Gln Ala Ala Gln Met Leu Gln 
                85                  90                  95      


Ser Asp Pro Tyr Ser Val Pro Ala Arg Asp Tyr Leu Ile Asp Gly Ser 
            100                 105                 110         


Arg Gly Ile Leu Ser Gly Thr Ser Asp Leu Leu Leu Thr Phe Asp Glu 
        115                 120                 125             


Ala Glu Val Arg Lys Ile Ile Arg Val Cys Lys Gly Ile Leu Glu Tyr 
    130                 135                 140                 


Leu Thr Val Ala Glu Val Val Glu Thr Met Glu Asp Leu Val Thr Tyr 
145                 150                 155                 160 


Thr Lys Asn Leu Gly Pro Gly Met Thr Lys Met Ala Lys Met Ile Asp 
                165                 170                 175     


Glu Arg Gln Gln Glu Leu Thr His Gln Glu His Arg Val Met Leu Val 
            180                 185                 190         


Asn Ser Met Asn Thr Val Lys Glu Leu Leu Pro Val Leu Ile Ser Ala 
        195                 200                 205             


Met Lys Ile Phe Val Thr Thr Lys Asn Ser Lys Asn Gln Gly Ile Glu 
    210                 215                 220                 


Glu Ala Leu Lys Asn Arg Asn Phe Thr Val Glu Lys Met Ser Ala Glu 
225                 230                 235                 240 


Ile Asn Glu Ile Ile Arg Val Leu Gln Leu Thr Ser Trp Asp Glu Asp 
                245                 250                 255     


Ala Trp Ala Ser Lys Asp Thr Glu Ala Met Lys Arg Ala Leu Ala Ser 
            260                 265                 270         


Ile Asp Ser Lys Leu Asn Gln Ala Lys Gly Trp Leu Arg Asp Pro Ser 
        275                 280                 285             


Ala Ser Pro Gly Asp Ala Gly Glu Gln Ala Ile Arg Gln Ile Leu Asp 
    290                 295                 300                 


Glu Ala Gly Lys Val Gly Glu Leu Cys Ala Gly Lys Glu Arg Arg Glu 
305                 310                 315                 320 


Ile Leu Gly Thr Cys Lys Met Leu Gly Gln Met Thr Asp Gln Val Ala 
                325                 330                 335     


Asp Leu Arg Ala Arg Gly Gln Gly Ser Ser Pro Val Ala Met Gln Lys 
            340                 345                 350         


Ala Gln Gln Val Ser Gln Gly Leu Asp Val Leu Thr Ala Lys Val Glu 
        355                 360                 365             


Asn Ala Ala Arg Lys Leu Glu Ala Met Thr Asn Ser Lys Gln Ser Ile 
    370                 375                 380                 


Ala Lys Lys Ile Asp Ala Ala Gln Asn Trp Leu Ala Asp Pro Asn Gly 
385                 390                 395                 400 


Gly Pro Glu Gly Glu Glu Gln Ile Arg Gly Ala Leu Ala Glu Ala Arg 
                405                 410                 415     


Lys Ile Ala Glu Leu Cys Asp Asp Pro Lys Glu Arg Asp Asp Ile Leu 
            420                 425                 430         


Arg Ser Leu Gly Glu Ile Ser Ala Leu Thr Ser Lys Leu Ala Asp Leu 
        435                 440                 445             


Arg Arg Gln Gly Lys Gly Asp Ser Pro Glu Ala Arg Ala Leu Ala Lys 
    450                 455                 460                 


Gln Val Ala Thr Ala Leu Gln Asn Leu Gln Thr Lys Thr Asn Arg Ala 
465                 470                 475                 480 


Val Ala Asn Ser Arg Pro Ala Lys Ala Ala Val His Leu Glu Gly Lys 
                485                 490                 495     


Ile Glu Gln Ala Gln Arg Trp Ile Asp Asn Pro Thr Val Asp Asp Arg 
            500                 505                 510         


Gly Val Gly Gln Ala Ala Ile Arg Gly Leu Val Ala Glu Gly His Arg 
        515                 520                 525             


Leu Ala Asn Val Met Met Gly Pro Tyr Arg Gln Asp Leu Leu Ala Lys 
    530                 535                 540                 


Cys Asp Arg Val Asp Gln Leu Thr Ala Gln Leu Ala Asp Leu Ala Ala 
545                 550                 555                 560 


Arg Gly Glu Gly Glu Ser Pro Gln Ala Arg Ala Leu Ala Ser Gln Leu 
                565                 570                 575     


Gln Asp Ser Leu Lys Asp Leu Lys Ala Arg Met Gln Glu Ala Met Thr 
            580                 585                 590         


Gln Glu Val Ser Asp Val Phe Ser Asp Thr Thr Thr Pro Ile Lys Leu 
        595                 600                 605             


Leu Ala Val Ala Ala Thr Ala Pro Pro Asp Ala Pro Asn Arg Glu Glu 
    610                 615                 620                 


Val Phe Asp Glu Arg Ala Ala Asn Phe Glu Asn His Ser Gly Lys Leu 
625                 630                 635                 640 


Gly Ala Thr Ala Glu Lys Ala Ala Ala Val Gly Thr Ala Asn Lys Ser 
                645                 650                 655     


Thr Val Glu Gly Ile Gln Ala Ser Val Lys Thr Ala Arg Glu Leu Thr 
            660                 665                 670         


Pro Gln Val Val Ser Ala Ala Arg Ile Leu Leu Arg Asn Pro Gly Asn 
        675                 680                 685             


Gln Ala Ala Tyr Glu His Phe Glu Thr Met Lys Asn Gln Trp Ile Asp 
    690                 695                 700                 


Asn Val Glu Lys Met Thr Gly Leu Val Asp Glu Ala Ile Asp Thr Lys 
705                 710                 715                 720 


Ser Leu Leu Asp Ala Ser Glu Glu Ala Ile Lys Lys Asp Leu Asp Lys 
                725                 730                 735     


Cys Lys Val Ala Met Ala Asn Ile Gln Pro Gln Met Leu Val Ala Gly 
            740                 745                 750         


Ala Thr Ser Ile Ala Arg Arg Ala Asn Arg Ile Leu Leu Val Ala Lys 
        755                 760                 765             


Arg Glu Val Glu Asn Ser Glu Asp Pro Lys Phe Arg Glu Ala Val Lys 
    770                 775                 780                 


Ala Ala Ser Asp Glu Leu Ser Lys Thr Ile Ser Pro Met Val Met Asp 
785                 790                 795                 800 


Ala Lys Ala Val Ala Gly Asn Ile Ser Asp Pro Gly Leu Gln Lys Ser 
                805                 810                 815     


Phe Leu Asp Ser Gly Tyr Arg Ile Leu Gly Ala Val Ala Lys Val Arg 
            820                 825                 830         


Glu Ala Phe Gln Pro Gln Glu Pro Asp Phe Pro Pro Pro Pro Pro Asp 
        835                 840                 845             


Leu Glu Gln Leu Arg Leu Thr Asp Glu Leu Ala Pro Pro Lys Pro Pro 
    850                 855                 860                 


Leu Pro Glu Gly Glu Val Pro Pro Pro Arg Pro Pro Pro Pro Glu Glu 
865                 870                 875                 880 


Lys Asp Glu Glu Phe Pro Glu Gln Lys Ala Gly Glu Val Ile Asn Gln 
                885                 890                 895     


Pro Met Met Met Ala Ala Arg Gln Leu His Asp Glu Ala Arg Lys Trp 
            900                 905                 910         


Ser Ser Lys Pro Gly Ile Pro Ala Ala Glu Val Gly Ile Gly Val Val 
        915                 920                 925             


Ala Glu Ala Asp Ala Ala Asp Ala Ala Gly Phe Pro Val Pro Pro Asp 
    930                 935                 940                 


Met Glu Asp Asp Tyr Glu Pro Glu Leu Leu Leu Met Pro Ser Asn Gln 
945                 950                 955                 960 


Pro Val Asn Gln Pro Ile Leu Ala Ala Ala Gln Ser Leu His Arg Glu 
                965                 970                 975     


Ala Thr Lys Trp Ser Ser Lys Gly Asn Asp Ile Ile Ala Ala Ala Lys 
            980                 985                 990         


Arg Met Ala Leu Leu Met Ala Glu  Met Ser Arg Leu Val  Arg Gly Gly 
        995                 1000                 1005             


Ser Gly  Thr Lys Arg Ala Leu  Ile Gln Cys Ala Lys  Asp Ile Ala 
    1010                 1015                 1020             


Lys Ala  Ser Asp Glu Val Thr  Arg Leu Ala Lys Glu  Val Ala Lys 
    1025                 1030                 1035             


Gln Cys  Thr Asp Lys Arg Ile  Arg Thr Asn Leu Leu  Gln Val Cys 
    1040                 1045                 1050             


Glu Arg  Ile Pro Thr Ile Ser  Thr Gln Leu Lys Ile  Leu Ser Thr 
    1055                 1060                 1065             


Val Lys  Ala Thr Met Leu Gly  Arg Thr Asn Ile Ser  Asp Glu Glu 
    1070                 1075                 1080             


Ser Glu  Gln Ala Thr Glu Met  Leu Val His Asn Ala  Gln Asn Leu 
    1085                 1090                 1095             


Met Gln  Ser Val Lys Glu Thr  Val Arg Glu Ala Glu  Ala Ala Ser 
    1100                 1105                 1110             


Ile Lys  Ile Arg Thr Asp Ala  Gly Phe Thr Leu Arg  Trp Val Arg 
    1115                 1120                 1125             


Lys Thr  Pro Trp Tyr Gln 
    1130                 


<210>  26
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 
            100                 105                 110         


Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg 
305                 310                 315                 320 


Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser 
    370                 375                 380                 


Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln 
                405                 410                 415     


Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu 
            420                 425                 430         


Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys 
        435                 440                 445             


Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys 
    450                 455                 460                 


Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln 
465                 470                 475                 480 


Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala 
                485                 490                 495     


Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala 
            500                 505                 510         


Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu 
        515                 520                 525             


Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile 
    530                 535                 540                 


His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg 
545                 550                 555                 560 


Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser 
                565                 570                 575     


Met 
    


<210>  27
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Gly Leu Asn Ser Leu Glu Ala Val Lys Arg Lys Ile Gln Ala 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Glu Ala Glu Asp Arg Ala Gln Gly Leu Gln 
            20                  25                  30          


Arg Glu Leu Asp Gly Glu Arg Glu Arg Arg Glu Lys Ala Glu Gly Asp 
        35                  40                  45              


Val Ala Ala Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Met Lys Asp Glu Glu Lys Met Glu Ile Gln Glu Met Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Leu Glu Gly Glu Leu Glu Arg Ala Glu 
    130                 135                 140                 


Glu Arg Ala Glu Val Ser Glu Leu Lys Cys Gly Asp Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Ala Ser Glu 
                165                 170                 175     


Lys Tyr Ser Glu Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Leu Leu 
            180                 185                 190         


Ser Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Thr Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Lys Leu 
    210                 215                 220                 


Ala Gln Ala Lys Glu Glu Asn Val Gly Leu His Gln Thr Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Asn Glu Leu Asn Cys Ile 
                245             


<210>  28
<211>  892
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Asp His Tyr Asp Ser Gln Gln Thr Asn Asp Tyr Met Gln Pro Glu 
1               5                   10                  15      


Glu Asp Trp Asp Arg Asp Leu Leu Leu Asp Pro Ala Trp Glu Lys Gln 
            20                  25                  30          


Gln Arg Lys Thr Phe Thr Ala Trp Cys Asn Ser His Leu Arg Lys Ala 
        35                  40                  45              


Gly Thr Gln Ile Glu Asn Ile Glu Glu Asp Phe Arg Asp Gly Leu Lys 
    50                  55                  60                  


Leu Met Leu Leu Leu Glu Val Ile Ser Gly Glu Arg Leu Ala Lys Pro 
65                  70                  75                  80  


Glu Arg Gly Lys Met Arg Val His Lys Ile Ser Asn Val Asn Lys Ala 
                85                  90                  95      


Leu Asp Phe Ile Ala Ser Lys Gly Val Lys Leu Val Ser Ile Gly Ala 
            100                 105                 110         


Glu Glu Ile Val Asp Gly Asn Val Lys Met Thr Leu Gly Met Ile Trp 
        115                 120                 125             


Thr Ile Ile Leu Arg Phe Ala Ile Gln Asp Ile Ser Val Glu Glu Thr 
    130                 135                 140                 


Ser Ala Lys Glu Gly Leu Leu Leu Trp Cys Gln Arg Lys Thr Ala Pro 
145                 150                 155                 160 


Tyr Lys Asn Val Asn Ile Gln Asn Phe His Ile Ser Trp Lys Asp Gly 
                165                 170                 175     


Leu Gly Phe Cys Ala Leu Ile His Arg His Arg Pro Glu Leu Ile Asp 
            180                 185                 190         


Tyr Gly Lys Leu Arg Lys Asp Asp Pro Leu Thr Asn Leu Asn Thr Ala 
        195                 200                 205             


Phe Asp Val Ala Glu Lys Tyr Leu Asp Ile Pro Lys Met Leu Asp Ala 
    210                 215                 220                 


Glu Asp Ile Val Gly Thr Ala Arg Pro Asp Glu Lys Ala Ile Met Thr 
225                 230                 235                 240 


Tyr Val Ser Ser Phe Tyr His Ala Phe Ser Gly Ala Gln Lys Ala Glu 
                245                 250                 255     


Thr Ala Ala Asn Arg Ile Cys Lys Val Leu Ala Val Asn Gln Glu Asn 
            260                 265                 270         


Glu Gln Leu Met Glu Asp Tyr Glu Lys Leu Ala Ser Asp Leu Leu Glu 
        275                 280                 285             


Trp Ile Arg Arg Thr Ile Pro Trp Leu Glu Asn Arg Val Pro Glu Asn 
    290                 295                 300                 


Thr Met His Ala Met Gln Gln Lys Leu Glu Asp Phe Arg Asp Tyr Arg 
305                 310                 315                 320 


Arg Leu His Lys Pro Pro Lys Val Gln Glu Lys Cys Gln Leu Glu Ile 
                325                 330                 335     


Asn Phe Asn Thr Leu Gln Thr Lys Leu Arg Leu Ser Asn Arg Pro Ala 
            340                 345                 350         


Phe Met Pro Ser Glu Gly Arg Met Val Ser Asp Ile Asn Asn Ala Trp 
        355                 360                 365             


Gly Cys Leu Glu Gln Val Glu Lys Gly Tyr Glu Glu Trp Leu Leu Asn 
    370                 375                 380                 


Glu Ile Arg Arg Leu Glu Arg Leu Asp His Leu Ala Glu Lys Phe Arg 
385                 390                 395                 400 


Gln Lys Ala Ser Ile His Glu Ala Trp Thr Asp Gly Lys Glu Ala Met 
                405                 410                 415     


Leu Arg Gln Lys Asp Tyr Glu Thr Ala Thr Leu Ser Glu Ile Lys Ala 
            420                 425                 430         


Leu Leu Lys Lys His Glu Ala Phe Glu Ser Asp Leu Ala Ala His Gln 
        435                 440                 445             


Asp Arg Val Glu Gln Ile Ala Ala Ile Ala Gln Glu Leu Asn Glu Leu 
    450                 455                 460                 


Asp Tyr Tyr Asp Ser Pro Ser Val Asn Ala Arg Cys Gln Lys Ile Cys 
465                 470                 475                 480 


Asp Gln Trp Asp Asn Leu Gly Ala Leu Thr Gln Lys Arg Arg Glu Ala 
                485                 490                 495     


Leu Glu Arg Thr Glu Lys Leu Leu Glu Thr Ile Asp Gln Leu Tyr Leu 
            500                 505                 510         


Glu Tyr Ala Lys Arg Ala Ala Pro Phe Asn Asn Trp Met Glu Gly Ala 
        515                 520                 525             


Met Glu Asp Leu Gln Asp Thr Phe Ile Val His Thr Ile Glu Glu Ile 
    530                 535                 540                 


Gln Gly Leu Thr Thr Ala His Glu Gln Phe Lys Ala Thr Leu Pro Asp 
545                 550                 555                 560 


Ala Asp Lys Glu Arg Leu Ala Ile Leu Gly Ile His Asn Glu Val Ser 
                565                 570                 575     


Lys Ile Val Gln Thr Tyr His Val Asn Met Ala Gly Thr Asn Pro Tyr 
            580                 585                 590         


Thr Thr Ile Thr Pro Gln Glu Ile Asn Gly Lys Trp Asp His Val Arg 
        595                 600                 605             


Gln Leu Val Pro Arg Arg Asp Gln Ala Leu Thr Glu Glu His Ala Arg 
    610                 615                 620                 


Gln Gln His Asn Glu Arg Leu Arg Lys Gln Phe Gly Ala Gln Ala Asn 
625                 630                 635                 640 


Val Ile Gly Pro Trp Ile Gln Thr Lys Met Glu Glu Ile Gly Arg Ile 
                645                 650                 655     


Ser Ile Glu Met His Gly Thr Leu Glu Asp Gln Leu Ser His Leu Arg 
            660                 665                 670         


Gln Tyr Glu Lys Ser Ile Val Asn Tyr Lys Pro Lys Ile Asp Gln Leu 
        675                 680                 685             


Glu Gly Asp His Gln Leu Ile Gln Glu Ala Leu Ile Phe Asp Asn Lys 
    690                 695                 700                 


His Thr Asn Tyr Thr Met Glu His Ile Arg Val Gly Trp Glu Gln Leu 
705                 710                 715                 720 


Leu Thr Thr Ile Ala Arg Thr Ile Asn Glu Val Glu Asn Gln Ile Leu 
                725                 730                 735     


Thr Arg Asp Ala Lys Gly Ile Ser Gln Glu Gln Met Asn Glu Phe Arg 
            740                 745                 750         


Ala Ser Phe Asn His Phe Asp Arg Asp His Ser Gly Thr Leu Gly Pro 
        755                 760                 765             


Glu Glu Phe Lys Ala Cys Leu Ile Ser Leu Gly Tyr Asp Ile Gly Asn 
    770                 775                 780                 


Asp Pro Gln Gly Glu Ala Glu Phe Ala Arg Ile Met Ser Ile Val Asp 
785                 790                 795                 800 


Pro Asn Arg Leu Gly Val Val Thr Phe Gln Ala Phe Ile Asp Phe Met 
                805                 810                 815     


Ser Arg Glu Thr Ala Asp Thr Asp Thr Ala Asp Gln Val Met Ala Ser 
            820                 825                 830         


Phe Lys Ile Leu Ala Gly Asp Lys Asn Tyr Ile Thr Met Asp Glu Leu 
        835                 840                 845             


Arg Arg Glu Leu Pro Pro Asp Gln Ala Glu Tyr Cys Ile Ala Arg Met 
    850                 855                 860                 


Ala Pro Tyr Thr Gly Pro Asp Ser Val Pro Gly Ala Leu Asp Tyr Met 
865                 870                 875                 880 


Ser Phe Ser Thr Ala Leu Tyr Gly Glu Ser Asp Leu 
                885                 890         


<210>  29
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Tyr Thr Ala Ile Pro Gln Ser Gly Ser Pro Phe Pro Gly Ser Val 
1               5                   10                  15      


Gln Asp Pro Gly Leu His Val Trp Arg Val Glu Lys Leu Lys Pro Val 
            20                  25                  30          


Pro Val Ala Gln Glu Asn Gln Gly Val Phe Phe Ser Gly Asp Ser Tyr 
        35                  40                  45              


Leu Val Leu His Asn Gly Pro Glu Glu Val Ser His Leu His Leu Trp 
    50                  55                  60                  


Ile Gly Gln Gln Ser Ser Arg Asp Glu Gln Gly Ala Cys Ala Val Leu 
65                  70                  75                  80  


Ala Val His Leu Asn Thr Leu Leu Gly Glu Arg Pro Val Gln His Arg 
                85                  90                  95      


Glu Val Gln Gly Asn Glu Ser Asp Leu Phe Met Ser Tyr Phe Pro Arg 
            100                 105                 110         


Gly Leu Lys Tyr Gln Glu Gly Gly Val Glu Ser Ala Phe His Lys Thr 
        115                 120                 125             


Ser Thr Gly Ala Pro Ala Ala Ile Lys Lys Leu Tyr Gln Val Lys Gly 
    130                 135                 140                 


Lys Lys Asn Ile Arg Ala Thr Glu Arg Ala Leu Asn Trp Asp Ser Phe 
145                 150                 155                 160 


Asn Thr Gly Asp Cys Phe Ile Leu Asp Leu Gly Gln Asn Ile Phe Ala 
                165                 170                 175     


Trp Cys Gly Gly Lys Ser Asn Ile Leu Glu Arg Asn Lys Ala Arg Asp 
            180                 185                 190         


Leu Ala Leu Ala Ile Arg Asp Ser Glu Arg Gln Gly Lys Ala Gln Val 
        195                 200                 205             


Glu Ile Val Thr Asp Gly Glu Glu Pro Ala Glu Met Ile Gln Val Leu 
    210                 215                 220                 


Gly Pro Lys Pro Ala Leu Lys Glu Gly Asn Pro Glu Glu Asp Leu Thr 
225                 230                 235                 240 


Ala Asp Lys Ala Asn Ala Gln Ala Ala Ala Leu Tyr Lys Val Ser Asp 
                245                 250                 255     


Ala Thr Gly Gln Met Asn Leu Thr Lys Val Ala Asp Ser Ser Pro Phe 
            260                 265                 270         


Ala Leu Glu Leu Leu Ile Ser Asp Asp Cys Phe Val Leu Asp Asn Gly 
        275                 280                 285             


Leu Cys Gly Lys Ile Tyr Ile Trp Lys Gly Arg Lys Ala Asn Glu Lys 
    290                 295                 300                 


Glu Arg Gln Ala Ala Leu Gln Val Ala Glu Gly Phe Ile Ser Arg Met 
305                 310                 315                 320 


Gln Tyr Ala Pro Asn Thr Gln Val Glu Ile Leu Pro Gln Gly His Glu 
                325                 330                 335     


Ser Pro Ile Phe Lys Gln Phe Phe Lys Asp Trp Lys 
            340                 345             


<210>  30
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Asp Phe Asp Asp Arg Val Ser Asp Glu Glu Lys Val Arg Ile 
1               5                   10                  15      


Ala Ala Lys Phe Ile Thr His Ala Pro Pro Gly Glu Phe Asn Glu Val 
            20                  25                  30          


Phe Asn Asp Val Arg Leu Leu Leu Asn Asn Asp Asn Leu Leu Arg Glu 
        35                  40                  45              


Gly Ala Ala His Ala Phe Ala Gln Tyr Asn Met Asp Gln Phe Thr Pro 
    50                  55                  60                  


Val Lys Ile Glu Gly Tyr Glu Asp Gln Val Leu Ile Thr Glu His Gly 
65                  70                  75                  80  


Asp Leu Gly Asn Ser Arg Phe Leu Asp Pro Arg Asn Lys Ile Ser Phe 
                85                  90                  95      


Lys Phe Asp His Leu Arg Lys Glu Ala Ser Asp Pro Gln Pro Glu Glu 
            100                 105                 110         


Ala Asp Gly Gly Leu Lys Ser Trp Arg Glu Ser Cys Asp Ser Ala Leu 
        115                 120                 125             


Arg Ala Tyr Val Lys Asp His Tyr Ser Asn Gly Phe Cys Thr Val Tyr 
    130                 135                 140                 


Ala Lys Thr Ile Asp Gly Gln Gln Thr Ile Ile Ala Cys Ile Glu Ser 
145                 150                 155                 160 


His Gln Phe Gln Pro Lys Asn Phe Trp Asn Gly Arg Trp Arg Ser Glu 
                165                 170                 175     


Trp Lys Phe Thr Ile Thr Pro Pro Thr Ala Gln Val Val Gly Val Leu 
            180                 185                 190         


Lys Ile Gln Val His Tyr Tyr Glu Asp Gly Asn Val Gln Leu Val Ser 
        195                 200                 205             


His Lys Asp Val Gln Asp Ser Leu Thr Val Ser Asn Glu Ala Gln Thr 
    210                 215                 220                 


Ala Lys Glu Phe Ile Lys Ile Ile Glu Asn Ala Glu Asn Glu Tyr Gln 
225                 230                 235                 240 


Thr Ala Ile Ser Glu Asn Tyr Gln Thr Met Ser Asp Thr Thr Phe Lys 
                245                 250                 255     


Ala Leu Arg Arg Gln Leu Pro Val Thr Arg Thr Lys Ile Asp Trp Asn 
            260                 265                 270         


Lys Ile Leu Ser Tyr Lys Ile Gly Lys Glu Met Gln Asn Ala 
        275                 280                 285     


<210>  31
<211>  2541
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Val Ala Leu Ser Leu Lys Ile Ser Ile Gly Asn Val Val Lys Thr 
1               5                   10                  15      


Met Gln Phe Glu Pro Ser Thr Met Val Tyr Asp Ala Cys Arg Ile Ile 
            20                  25                  30          


Arg Glu Arg Ile Pro Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 
        35                  40                  45              


Leu Phe Leu Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 
    50                  55                  60                  


Gly Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 
65                  70                  75                  80  


Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly Thr 
                85                  90                  95      


Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr Asp Met Leu 
            100                 105                 110         


Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn His Asp Glu Tyr Ser 
        115                 120                 125             


Leu Val Arg Glu Leu Met Glu Glu Lys Lys Glu Glu Ile Thr Gly Thr 
    130                 135                 140                 


Leu Arg Lys Asp Lys Thr Leu Leu Arg Asp Glu Lys Lys Met Glu Lys 
145                 150                 155                 160 


Leu Lys Gln Lys Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 
                165                 170                 175     


Gly Arg Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 
            180                 185                 190         


Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 
        195                 200                 205             


Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile Leu 
    210                 215                 220                 


Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu Phe Ala Gly 
225                 230                 235                 240 


Phe Gln Cys Gln Ile Gln Phe Gly Pro His Asn Glu Gln Lys His Lys 
                245                 250                 255     


Ala Gly Phe Leu Asp Leu Lys Asp Phe Leu Pro Lys Glu Tyr Val Lys 
            260                 265                 270         


Gln Lys Gly Glu Arg Lys Ile Phe Gln Ala His Lys Asn Cys Gly Gln 
        275                 280                 285             


Met Ser Glu Ile Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 
    290                 295                 300                 


Leu Lys Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 
305                 310                 315                 320 


Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys 
                325                 330                 335     


Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu Trp Asn 
            340                 345                 350         


Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys Ser Phe Thr Leu 
        355                 360                 365             


Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Thr Thr Glu 
    370                 375                 380                 


Gly Glu Gln Ile Ala Gln Leu Ile Ala Gly Tyr Ile Asp Ile Ile Leu 
385                 390                 395                 400 


Lys Lys Lys Lys Ser Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 
                405                 410                 415     


Ser Thr Met Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 
            420                 425                 430         


Gln Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 
        435                 440                 445             


Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln 
    450                 455                 460                 


Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly Gln Met 
465                 470                 475                 480 


His Arg Gly His Met Pro Pro Leu Thr Ser Ala Gln Gln Ala Leu Thr 
                485                 490                 495     


Gly Thr Ile Asn Ser Ser Met Gln Ala Val Gln Ala Ala Gln Ala Thr 
            500                 505                 510         


Leu Asp Asp Phe Asp Thr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ser 
        515                 520                 525             


Lys Ala Trp Arg Lys Asn Lys Met Asp Glu Ser Lys His Glu Ile His 
    530                 535                 540                 


Ser Gln Val Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 
545                 550                 555                 560 


Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 
                565                 570                 575     


Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val Lys 
            580                 585                 590         


Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly Arg Pro Leu 
        595                 600                 605             


Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val Ser Glu Leu Leu Arg 
    610                 615                 620                 


Ser Ala Gln Pro Ala Ser Ala Glu Pro Arg Gln Asn Leu Leu Gln Ala 
625                 630                 635                 640 


Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 
                645                 650                 655     


Glu Ser Asp Thr Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 
            660                 665                 670         


Lys Ala Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 
        675                 680                 685             


Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 
    690                 695                 700                 


Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys Thr 
705                 710                 715                 720 


Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys Gln Glu Gln Leu 
                725                 730                 735     


Val Glu Ala Gly Arg Leu Val Ala Lys Ala Val Glu Gly Cys Val Ser 
            740                 745                 750         


Ala Ser Gln Ala Ala Thr Glu Asp Gly Gln Leu Leu Arg Gly Val Gly 
        755                 760                 765             


Ala Ala Ala Thr Ala Val Thr Gln Ala Leu Asn Glu Leu Leu Gln His 
    770                 775                 780                 


Val Lys Ala His Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 
785                 790                 795                 800 


Ala Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 
                805                 810                 815     


Gly Asp Ala Gly Glu Met Val Arg Gln Ala Arg Ile Leu Ala Gln Ala 
            820                 825                 830         


Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly Glu Ser 
        835                 840                 845             


Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala Lys Ile Leu Ala 
    850                 855                 860                 


Asp Ala Thr Ala Lys Met Val Glu Ala Ala Lys Gly Ala Ala Ala His 
865                 870                 875                 880 


Pro Asp Ser Glu Glu Gln Gln Gln Arg Leu Arg Glu Ala Ala Glu Gly 
                885                 890                 895     


Leu Arg Met Ala Thr Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 
            900                 905                 910         


Leu Val Gln Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 
        915                 920                 925             


Thr Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 
    930                 935                 940                 


Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala 
945                 950                 955                 960 


Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser Gln Ala Gln 
                965                 970                 975     


Pro Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 
            980                 985                 990         


Phe Leu Gln Pro Gly Gly Lys Met  Val Ala Ala Ala Lys  Ala Ser Val 
        995                 1000                 1005             


Pro Thr  Ile Gln Asp Gln Ala  Ser Ala Met Gln Leu  Ser Gln Cys 
    1010                 1015                 1020             


Ala Lys  Asn Leu Gly Thr Ala  Leu Ala Glu Leu Arg  Thr Ala Ala 
    1025                 1030                 1035             


Gln Lys  Ala Gln Glu Ala Cys  Gly Pro Leu Glu Met  Asp Ser Ala 
    1040                 1045                 1050             


Leu Ser  Val Val Gln Asn Leu  Glu Lys Asp Leu Gln  Glu Val Lys 
    1055                 1060                 1065             


Ala Ala  Ala Arg Asp Gly Lys  Leu Lys Pro Leu Pro  Gly Glu Thr 
    1070                 1075                 1080             


Met Glu  Lys Cys Thr Gln Asp  Leu Gly Asn Ser Thr  Lys Ala Val 
    1085                 1090                 1095             


Ser Ser  Ala Ile Ala Gln Leu  Leu Gly Glu Val Ala  Gln Gly Asn 
    1100                 1105                 1110             


Glu Asn  Tyr Ala Gly Ile Ala  Ala Arg Asp Val Ala  Gly Gly Leu 
    1115                 1120                 1125             


Arg Ser  Leu Ala Gln Ala Ala  Arg Gly Val Ala Ala  Leu Thr Ser 
    1130                 1135                 1140             


Asp Pro  Ala Val Gln Ala Ile  Val Leu Asp Thr Ala  Ser Asp Val 
    1145                 1150                 1155             


Leu Asp  Lys Ala Ser Ser Leu  Ile Glu Glu Ala Lys  Lys Ala Ala 
    1160                 1165                 1170             


Gly His  Pro Gly Asp Pro Glu  Ser Gln Gln Arg Leu  Ala Gln Val 
    1175                 1180                 1185             


Ala Lys  Ala Val Thr Gln Ala  Leu Asn Arg Cys Val  Ser Cys Leu 
    1190                 1195                 1200             


Pro Gly  Gln Arg Asp Val Asp  Asn Ala Leu Arg Ala  Val Gly Asp 
    1205                 1210                 1215             


Ala Ser  Lys Arg Leu Leu Ser  Asp Ser Leu Pro Pro  Ser Thr Gly 
    1220                 1225                 1230             


Thr Phe  Gln Glu Ala Gln Ser  Arg Leu Asn Glu Ala  Ala Ala Gly 
    1235                 1240                 1245             


Leu Asn  Gln Ala Ala Thr Glu  Leu Val Gln Ala Ser  Arg Gly Thr 
    1250                 1255                 1260             


Pro Gln  Asp Leu Ala Arg Ala  Ser Gly Arg Phe Gly  Gln Asp Phe 
    1265                 1270                 1275             


Ser Thr  Phe Leu Glu Ala Gly  Val Glu Met Ala Gly  Gln Ala Pro 
    1280                 1285                 1290             


Ser Gln  Glu Asp Arg Ala Gln  Val Val Ser Asn Leu  Lys Gly Ile 
    1295                 1300                 1305             


Ser Met  Ser Ser Ser Lys Leu  Leu Leu Ala Ala Lys  Ala Leu Ser 
    1310                 1315                 1320             


Thr Asp  Pro Ala Ala Pro Asn  Leu Lys Ser Gln Leu  Ala Ala Ala 
    1325                 1330                 1335             


Ala Arg  Ala Val Thr Asp Ser  Ile Asn Gln Leu Ile  Thr Met Cys 
    1340                 1345                 1350             


Thr Gln  Gln Ala Pro Gly Gln  Lys Glu Cys Asp Asn  Ala Leu Arg 
    1355                 1360                 1365             


Glu Leu  Glu Thr Val Arg Glu  Leu Leu Glu Asn Pro  Val Gln Pro 
    1370                 1375                 1380             


Ile Asn  Asp Met Ser Tyr Phe  Gly Cys Leu Asp Ser  Val Met Glu 
    1385                 1390                 1395             


Asn Ser  Lys Val Leu Gly Glu  Ala Met Thr Gly Ile  Ser Gln Asn 
    1400                 1405                 1410             


Ala Lys  Asn Gly Asn Leu Pro  Glu Phe Gly Asp Ala  Ile Ser Thr 
    1415                 1420                 1425             


Ala Ser  Lys Ala Leu Cys Gly  Phe Thr Glu Ala Ala  Ala Gln Ala 
    1430                 1435                 1440             


Ala Tyr  Leu Val Gly Val Ser  Asp Pro Asn Ser Gln  Ala Gly Gln 
    1445                 1450                 1455             


Gln Gly  Leu Val Glu Pro Thr  Gln Phe Ala Arg Ala  Asn Gln Ala 
    1460                 1465                 1470             


Ile Gln  Met Ala Cys Gln Ser  Leu Gly Glu Pro Gly  Cys Thr Gln 
    1475                 1480                 1485             


Ala Gln  Val Leu Ser Ala Ala  Thr Ile Val Ala Lys  His Thr Ser 
    1490                 1495                 1500             


Ala Leu  Cys Asn Ser Cys Arg  Leu Ala Ser Ala Arg  Thr Thr Asn 
    1505                 1510                 1515             


Pro Thr  Ala Lys Arg Gln Phe  Val Gln Ser Ala Lys  Glu Val Ala 
    1520                 1525                 1530             


Asn Ser  Thr Ala Asn Leu Val  Lys Thr Ile Lys Ala  Leu Asp Gly 
    1535                 1540                 1545             


Ala Phe  Thr Glu Glu Asn Arg  Ala Gln Cys Arg Ala  Ala Thr Ala 
    1550                 1555                 1560             


Pro Leu  Leu Glu Ala Val Asp  Asn Leu Ser Ala Phe  Ala Ser Asn 
    1565                 1570                 1575             


Pro Glu  Phe Ser Ser Ile Pro  Ala Gln Ile Ser Pro  Glu Gly Arg 
    1580                 1585                 1590             


Ala Ala  Met Glu Pro Ile Val  Ile Ser Ala Lys Thr  Met Leu Glu 
    1595                 1600                 1605             


Ser Ala  Gly Gly Leu Ile Gln  Thr Ala Arg Ala Leu  Ala Val Asn 
    1610                 1615                 1620             


Pro Arg  Asp Pro Pro Ser Trp  Ser Val Leu Ala Gly  His Ser Arg 
    1625                 1630                 1635             


Thr Val  Ser Asp Ser Ile Lys  Lys Leu Ile Thr Ser  Met Arg Asp 
    1640                 1645                 1650             


Lys Ala  Pro Gly Gln Leu Glu  Cys Glu Thr Ala Ile  Ala Ala Leu 
    1655                 1660                 1665             


Asn Ser  Cys Leu Arg Asp Leu  Asp Gln Ala Ser Leu  Ala Ala Val 
    1670                 1675                 1680             


Ser Gln  Gln Leu Ala Pro Arg  Glu Gly Ile Ser Gln  Glu Ala Leu 
    1685                 1690                 1695             


His Thr  Gln Met Leu Thr Ala  Val Gln Glu Ile Ser  His Leu Ile 
    1700                 1705                 1710             


Glu Pro  Leu Ala Asn Ala Ala  Arg Ala Glu Ala Ser  Gln Leu Gly 
    1715                 1720                 1725             


His Lys  Val Ser Gln Met Ala  Gln Tyr Phe Glu Pro  Leu Thr Leu 
    1730                 1735                 1740             


Ala Ala  Val Gly Ala Ala Ser  Lys Thr Leu Ser His  Pro Gln Gln 
    1745                 1750                 1755             


Met Ala  Leu Leu Asp Gln Thr  Lys Thr Leu Ala Glu  Ser Ala Leu 
    1760                 1765                 1770             


Gln Leu  Leu Tyr Thr Ala Lys  Glu Ala Gly Gly Asn  Pro Lys Gln 
    1775                 1780                 1785             


Ala Ala  His Thr Gln Glu Ala  Leu Glu Glu Ala Val  Gln Met Met 
    1790                 1795                 1800             


Thr Glu  Ala Val Glu Asp Leu  Thr Thr Thr Leu Asn  Glu Ala Ala 
    1805                 1810                 1815             


Ser Ala  Ala Gly Val Val Gly  Gly Met Val Asp Ser  Ile Thr Gln 
    1820                 1825                 1830             


Ala Ile  Asn Gln Leu Asp Glu  Gly Pro Met Gly Glu  Pro Glu Gly 
    1835                 1840                 1845             


Ser Phe  Val Asp Tyr Gln Thr  Thr Met Val Arg Thr  Ala Lys Ala 
    1850                 1855                 1860             


Ile Ala  Val Thr Val Gln Glu  Met Val Thr Lys Ser  Asn Thr Ser 
    1865                 1870                 1875             


Pro Glu  Glu Leu Gly Pro Leu  Ala Asn Gln Leu Thr  Ser Asp Tyr 
    1880                 1885                 1890             


Gly Arg  Leu Ala Ser Glu Ala  Lys Pro Ala Ala Val  Ala Ala Glu 
    1895                 1900                 1905             


Asn Glu  Glu Ile Gly Ser His  Ile Lys His Arg Val  Gln Glu Leu 
    1910                 1915                 1920             


Gly His  Gly Cys Ala Ala Leu  Val Thr Lys Ala Gly  Ala Leu Gln 
    1925                 1930                 1935             


Cys Ser  Pro Ser Asp Ala Tyr  Thr Lys Lys Glu Leu  Ile Glu Cys 
    1940                 1945                 1950             


Ala Arg  Arg Val Ser Glu Lys  Val Ser His Val Leu  Ala Ala Leu 
    1955                 1960                 1965             


Gln Ala  Gly Asn Arg Gly Thr  Gln Ala Cys Ile Thr  Ala Ala Ser 
    1970                 1975                 1980             


Ala Val  Ser Gly Ile Ile Ala  Asp Leu Asp Thr Thr  Ile Met Phe 
    1985                 1990                 1995             


Ala Thr  Ala Gly Thr Leu Asn  Arg Glu Gly Thr Glu  Thr Phe Ala 
    2000                 2005                 2010             


Asp His  Arg Glu Gly Ile Leu  Lys Thr Ala Lys Val  Leu Val Glu 
    2015                 2020                 2025             


Asp Thr  Lys Val Leu Val Gln  Asn Ala Ala Gly Ser  Gln Glu Lys 
    2030                 2035                 2040             


Leu Ala  Gln Ala Ala Gln Ser  Ser Val Ala Thr Ile  Thr Arg Leu 
    2045                 2050                 2055             


Ala Asp  Val Val Lys Leu Gly  Ala Ala Ser Leu Gly  Ala Glu Asp 
    2060                 2065                 2070             


Pro Glu  Thr Gln Val Val Leu  Ile Asn Ala Val Lys  Asp Val Ala 
    2075                 2080                 2085             


Lys Ala  Leu Gly Asp Leu Ile  Ser Ala Thr Lys Ala  Ala Ala Gly 
    2090                 2095                 2100             


Lys Val  Gly Asp Asp Pro Ala  Val Trp Gln Leu Lys  Asn Ser Ala 
    2105                 2110                 2115             


Lys Val  Met Val Thr Asn Val  Thr Ser Leu Leu Lys  Thr Val Lys 
    2120                 2125                 2130             


Ala Val  Glu Asp Glu Ala Thr  Lys Gly Thr Arg Ala  Leu Glu Ala 
    2135                 2140                 2145             


Thr Thr  Glu His Ile Arg Gln  Glu Leu Ala Val Phe  Cys Ser Pro 
    2150                 2155                 2160             


Glu Pro  Pro Ala Lys Thr Ser  Thr Pro Glu Asp Phe  Ile Arg Met 
    2165                 2170                 2175             


Thr Lys  Gly Ile Thr Met Ala  Thr Ala Lys Ala Val  Ala Ala Gly 
    2180                 2185                 2190             


Asn Ser  Cys Arg Gln Glu Asp  Val Ile Ala Thr Ala  Asn Leu Ser 
    2195                 2200                 2205             


Arg Arg  Ala Ile Ala Asp Met  Leu Arg Ala Cys Lys  Glu Ala Ala 
    2210                 2215                 2220             


Tyr His  Pro Glu Val Ala Pro  Asp Val Arg Leu Arg  Ala Leu His 
    2225                 2230                 2235             


Tyr Gly  Arg Glu Cys Ala Asn  Gly Tyr Leu Glu Leu  Leu Asp His 
    2240                 2245                 2250             


Val Leu  Leu Thr Leu Gln Lys  Pro Ser Pro Glu Leu  Lys Gln Gln 
    2255                 2260                 2265             


Leu Thr  Gly His Ser Lys Arg  Val Ala Gly Ser Val  Thr Glu Leu 
    2270                 2275                 2280             


Ile Gln  Ala Ala Glu Ala Met  Lys Gly Thr Glu Trp  Val Asp Pro 
    2285                 2290                 2295             


Glu Asp  Pro Thr Val Ile Ala  Glu Asn Glu Leu Leu  Gly Ala Ala 
    2300                 2305                 2310             


Ala Ala  Ile Glu Ala Ala Ala  Lys Lys Leu Glu Gln  Leu Lys Pro 
    2315                 2320                 2325             


Arg Ala  Lys Pro Lys Glu Ala  Asp Glu Ser Leu Asn  Phe Glu Glu 
    2330                 2335                 2340             


Gln Ile  Leu Glu Ala Ala Lys  Ser Ile Ala Ala Ala  Thr Ser Ala 
    2345                 2350                 2355             


Leu Val  Lys Ala Ala Ser Ala  Ala Gln Arg Glu Leu  Val Ala Gln 
    2360                 2365                 2370             


Gly Lys  Val Gly Ala Ile Pro  Ala Asn Ala Leu Asp  Asp Gly Gln 
    2375                 2380                 2385             


Trp Ser  Gln Gly Leu Ile Ser  Ala Ala Arg Met Val  Ala Ala Ala 
    2390                 2395                 2400             


Thr Asn  Asn Leu Cys Glu Ala  Ala Asn Ala Ala Val  Gln Gly His 
    2405                 2410                 2415             


Ala Ser  Gln Glu Lys Leu Ile  Ser Ser Ala Lys Gln  Val Ala Ala 
    2420                 2425                 2430             


Ser Thr  Ala Gln Leu Leu Val  Ala Cys Lys Val Lys  Ala Asp Gln 
    2435                 2440                 2445             


Asp Ser  Glu Ala Met Lys Arg  Leu Gln Ala Ala Gly  Asn Ala Val 
    2450                 2455                 2460             


Lys Arg  Ala Ser Asp Asn Leu  Val Lys Ala Ala Gln  Lys Ala Ala 
    2465                 2470                 2475             


Ala Phe  Glu Glu Gln Glu Asn  Glu Thr Val Val Val  Lys Glu Lys 
    2480                 2485                 2490             


Met Val  Gly Gly Ile Ala Gln  Ile Ile Ala Ala Gln  Glu Glu Met 
    2495                 2500                 2505             


Leu Arg  Lys Glu Arg Glu Leu  Glu Glu Ala Arg Lys  Lys Leu Ala 
    2510                 2515                 2520             


Gln Ile  Arg Gln Gln Gln Tyr  Lys Phe Leu Pro Ser  Glu Leu Arg 
    2525                 2530                 2535             


Asp Glu  His 
    2540     


<210>  32
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln 
1               5                   10                  15      


Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln 
            20                  25                  30          


Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly 
        35                  40                  45              


Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu 
    50                  55                  60                  


Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile 
65                  70                  75                  80  


Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 
                85                  90                  95      


Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr 
        115                 120                 125             


Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe 
    130                 135                 140                 


Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg 
145                 150                 155                 160 


Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu 
                165                 170                 175     


Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 
            180                 185                 190         


Gly Met Pro Arg Gln Ile Leu 
        195                 


<210>  33
<211>  2647
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Val Ser  Ile Gly Gly 
    1640                 1645                 1650             


His Gly  Leu Gly Ala Gly Ile  Gly Pro Thr Ile Gln  Ile Gly Glu 
    1655                 1660                 1665             


Glu Thr  Val Ile Thr Val Asp  Thr Lys Ala Ala Gly  Lys Gly Lys 
    1670                 1675                 1680             


Val Thr  Cys Thr Val Cys Thr  Pro Asp Gly Ser Glu  Val Asp Val 
    1685                 1690                 1695             


Asp Val  Val Glu Asn Glu Asp  Gly Thr Phe Asp Ile  Phe Tyr Thr 
    1700                 1705                 1710             


Ala Pro  Gln Pro Gly Lys Tyr  Val Ile Cys Val Arg  Phe Gly Gly 
    1715                 1720                 1725             


Glu His  Val Pro Asn Ser Pro  Phe Gln Val Thr Ala  Leu Ala Gly 
    1730                 1735                 1740             


Asp Gln  Pro Ser Val Gln Pro  Pro Leu Arg Ser Gln  Gln Leu Ala 
    1745                 1750                 1755             


Pro Gln  Tyr Thr Tyr Ala Gln  Gly Gly Gln Gln Thr  Trp Ala Pro 
    1760                 1765                 1770             


Glu Arg  Pro Leu Val Gly Val  Asn Gly Leu Asp Val  Thr Ser Leu 
    1775                 1780                 1785             


Arg Pro  Phe Asp Leu Val Ile  Pro Phe Thr Ile Lys  Lys Gly Glu 
    1790                 1795                 1800             


Ile Thr  Gly Glu Val Arg Met  Pro Ser Gly Lys Val  Ala Gln Pro 
    1805                 1810                 1815             


Thr Ile  Thr Asp Asn Lys Asp  Gly Thr Val Thr Val  Arg Tyr Ala 
    1820                 1825                 1830             


Pro Ser  Glu Ala Gly Leu His  Glu Met Asp Ile Arg  Tyr Asp Asn 
    1835                 1840                 1845             


Met His  Ile Pro Gly Ser Pro  Leu Gln Phe Tyr Val  Asp Tyr Val 
    1850                 1855                 1860             


Asn Cys  Gly His Val Thr Ala  Tyr Gly Pro Gly Leu  Thr His Gly 
    1865                 1870                 1875             


Val Val  Asn Lys Pro Ala Thr  Phe Thr Val Asn Thr  Lys Asp Ala 
    1880                 1885                 1890             


Gly Glu  Gly Gly Leu Ser Leu  Ala Ile Glu Gly Pro  Ser Lys Ala 
    1895                 1900                 1905             


Glu Ile  Ser Cys Thr Asp Asn  Gln Asp Gly Thr Cys  Ser Val Ser 
    1910                 1915                 1920             


Tyr Leu  Pro Val Leu Pro Gly  Asp Tyr Ser Ile Leu  Val Lys Tyr 
    1925                 1930                 1935             


Asn Glu  Gln His Val Pro Gly  Ser Pro Phe Thr Ala  Arg Val Thr 
    1940                 1945                 1950             


Gly Asp  Asp Ser Met Arg Met  Ser His Leu Lys Val  Gly Ser Ala 
    1955                 1960                 1965             


Ala Asp  Ile Pro Ile Asn Ile  Ser Glu Thr Asp Leu  Ser Leu Leu 
    1970                 1975                 1980             


Thr Ala  Thr Val Val Pro Pro  Ser Gly Arg Glu Glu  Pro Cys Leu 
    1985                 1990                 1995             


Leu Lys  Arg Leu Arg Asn Gly  His Val Gly Ile Ser  Phe Val Pro 
    2000                 2005                 2010             


Lys Glu  Thr Gly Glu His Leu  Val His Val Lys Lys  Asn Gly Gln 
    2015                 2020                 2025             


His Val  Ala Ser Ser Pro Ile  Pro Val Val Ile Ser  Gln Ser Glu 
    2030                 2035                 2040             


Ile Gly  Asp Ala Ser Arg Val  Arg Val Ser Gly Gln  Gly Leu His 
    2045                 2050                 2055             


Glu Gly  His Thr Phe Glu Pro  Ala Glu Phe Ile Ile  Asp Thr Arg 
    2060                 2065                 2070             


Asp Ala  Gly Tyr Gly Gly Leu  Ser Leu Ser Ile Glu  Gly Pro Ser 
    2075                 2080                 2085             


Lys Val  Asp Ile Asn Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Arg 
    2090                 2095                 2100             


Val Thr  Tyr Cys Pro Thr Glu  Pro Gly Asn Tyr Ile  Ile Asn Ile 
    2105                 2110                 2115             


Lys Phe  Ala Asp Gln His Val  Pro Gly Ser Pro Phe  Ser Val Lys 
    2120                 2125                 2130             


Val Thr  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Arg Arg 
    2135                 2140                 2145             


Arg Ala  Pro Ser Val Ala Asn  Val Gly Ser His Cys  Asp Leu Ser 
    2150                 2155                 2160             


Leu Lys  Ile Pro Glu Ile Ser  Ile Gln Asp Met Thr  Ala Gln Val 
    2165                 2170                 2175             


Thr Ser  Pro Ser Gly Lys Thr  His Glu Ala Glu Ile  Val Glu Gly 
    2180                 2185                 2190             


Glu Asn  His Thr Tyr Cys Ile  Arg Phe Val Pro Ala  Glu Met Gly 
    2195                 2200                 2205             


Thr His  Thr Val Ser Val Lys  Tyr Lys Gly Gln His  Val Pro Gly 
    2210                 2215                 2220             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2225                 2230                 2235             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Ala Glu Ala 
    2240                 2245                 2250             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2255                 2260                 2265             


Gly Gly  Leu Ala Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2270                 2275                 2280             


Ser Phe  Glu Asp Arg Lys Asp  Gly Ser Cys Gly Val  Ala Tyr Val 
    2285                 2290                 2295             


Val Gln  Glu Pro Gly Asp Tyr  Glu Val Ser Val Lys  Phe Asn Glu 
    2300                 2305                 2310             


Glu His  Ile Pro Asp Ser Pro  Phe Val Val Pro Val  Ala Ser Pro 
    2315                 2320                 2325             


Ser Gly  Asp Ala Arg Arg Leu  Thr Val Ser Ser Leu  Gln Glu Ser 
    2330                 2335                 2340             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Val  Ser Leu Asn 
    2345                 2350                 2355             


Gly Ala  Lys Gly Ala Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2360                 2365                 2370             


Ala Leu  Glu Glu Cys Tyr Val  Thr Glu Ile Asp Gln  Asp Lys Tyr 
    2375                 2380                 2385             


Ala Val  Arg Phe Ile Pro Arg  Glu Asn Gly Val Tyr  Leu Ile Asp 
    2390                 2395                 2400             


Val Lys  Phe Asn Gly Thr His  Ile Pro Gly Ser Pro  Phe Lys Ile 
    2405                 2410                 2415             


Arg Val  Gly Glu Pro Gly His  Gly Gly Asp Pro Gly  Leu Val Ser 
    2420                 2425                 2430             


Ala Tyr  Gly Ala Gly Leu Glu  Gly Gly Val Thr Gly  Asn Pro Ala 
    2435                 2440                 2445             


Glu Phe  Val Val Asn Thr Ser  Asn Ala Gly Ala Gly  Ala Leu Ser 
    2450                 2455                 2460             


Val Thr  Ile Asp Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2465                 2470                 2475             


Cys Pro  Glu Gly Tyr Arg Val  Thr Tyr Thr Pro Met  Ala Pro Gly 
    2480                 2485                 2490             


Ser Tyr  Leu Ile Ser Ile Lys  Tyr Gly Gly Pro Tyr  His Ile Gly 
    2495                 2500                 2505             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Pro Arg  Leu Val Ser 
    2510                 2515                 2520             


Asn His  Ser Leu His Glu Thr  Ser Ser Val Phe Val  Asp Ser Leu 
    2525                 2530                 2535             


Thr Lys  Ala Thr Cys Ala Pro  Gln His Gly Ala Pro  Gly Pro Gly 
    2540                 2545                 2550             


Pro Ala  Asp Ala Ser Lys Val  Val Ala Lys Gly Leu  Gly Leu Ser 
    2555                 2560                 2565             


Lys Ala  Tyr Val Gly Gln Lys  Ser Ser Phe Thr Val  Asp Cys Ser 
    2570                 2575                 2580             


Lys Ala  Gly Asn Asn Met Leu  Leu Val Gly Val His  Gly Pro Arg 
    2585                 2590                 2595             


Thr Pro  Cys Glu Glu Ile Leu  Val Lys His Val Gly  Ser Arg Leu 
    2600                 2605                 2610             


Tyr Ser  Val Ser Tyr Leu Leu  Lys Asp Lys Gly Glu  Tyr Thr Leu 
    2615                 2620                 2625             


Val Val  Lys Trp Gly Asp Glu  His Ile Pro Gly Ser  Pro Tyr Arg 
    2630                 2635                 2640             


Val Val  Val Pro 
    2645         


<210>  34
<211>  3259
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Leu Ser Arg Leu Ser Gly Leu Ala Asn Val Val Leu His Glu Leu 
1               5                   10                  15      


Ser Gly Asp Asp Asp Thr Asp Gln Asn Met Arg Ala Pro Leu Asp Pro 
            20                  25                  30          


Glu Leu His Gln Glu Ser Asp Met Glu Phe Asn Asn Thr Thr Gln Glu 
        35                  40                  45              


Asp Val Gln Glu Arg Leu Ala Tyr Ala Glu Gln Leu Val Val Glu Leu 
    50                  55                  60                  


Lys Asp Ile Ile Arg Gln Lys Asp Val Gln Leu Gln Gln Lys Asp Glu 
65                  70                  75                  80  


Ala Leu Gln Glu Glu Arg Lys Ala Ala Asp Asn Lys Ile Lys Lys Leu 
                85                  90                  95      


Lys Leu His Ala Lys Ala Lys Leu Thr Ser Leu Asn Lys Tyr Ile Glu 
            100                 105                 110         


Glu Met Lys Ala Gln Gly Gly Thr Val Leu Pro Thr Glu Pro Gln Ser 
        115                 120                 125             


Glu Glu Gln Leu Ser Lys His Asp Lys Ser Ser Thr Glu Glu Glu Met 
    130                 135                 140                 


Glu Ile Glu Lys Ile Lys His Lys Leu Gln Glu Lys Glu Glu Leu Ile 
145                 150                 155                 160 


Ser Thr Leu Gln Ala Gln Leu Thr Gln Ala Gln Ala Glu Gln Pro Ala 
                165                 170                 175     


Gln Ser Ser Thr Glu Met Glu Glu Phe Val Met Met Lys Gln Gln Leu 
            180                 185                 190         


Gln Glu Lys Glu Glu Phe Ile Ser Thr Leu Gln Ala Gln Leu Ser Gln 
        195                 200                 205             


Thr Gln Ala Glu Gln Ala Ala Gln Gln Val Val Arg Glu Lys Asp Ala 
    210                 215                 220                 


Arg Phe Glu Thr Gln Val Arg Leu His Glu Asp Glu Leu Leu Gln Leu 
225                 230                 235                 240 


Val Thr Gln Ala Asp Val Glu Thr Glu Met Gln Gln Lys Leu Arg Val 
                245                 250                 255     


Leu Gln Arg Lys Leu Glu Glu His Glu Glu Ser Leu Val Gly Arg Ala 
            260                 265                 270         


Gln Val Val Asp Leu Leu Gln Gln Glu Leu Thr Ala Ala Glu Gln Arg 
        275                 280                 285             


Asn Gln Ile Leu Ser Gln Gln Leu Gln Gln Met Glu Ala Glu His Asn 
    290                 295                 300                 


Thr Leu Arg Asn Thr Val Glu Thr Glu Arg Glu Glu Ser Lys Ile Leu 
305                 310                 315                 320 


Leu Glu Lys Met Glu Leu Glu Val Ala Glu Arg Lys Leu Ser Phe His 
                325                 330                 335     


Asn Leu Gln Glu Glu Met His His Leu Leu Glu Gln Phe Glu Gln Ala 
            340                 345                 350         


Gly Gln Ala Gln Ala Glu Leu Glu Ser Arg Tyr Ser Ala Leu Glu Gln 
        355                 360                 365             


Lys His Lys Ala Glu Met Glu Glu Lys Thr Ser His Ile Leu Ser Leu 
    370                 375                 380                 


Gln Lys Thr Gly Gln Glu Leu Gln Ser Ala Cys Asp Ala Leu Lys Asp 
385                 390                 395                 400 


Gln Asn Ser Lys Leu Leu Gln Asp Lys Asn Glu Gln Ala Val Gln Ser 
                405                 410                 415     


Ala Gln Thr Ile Gln Gln Leu Glu Asp Gln Leu Gln Gln Lys Ser Lys 
            420                 425                 430         


Glu Ile Ser Gln Phe Leu Asn Arg Leu Pro Leu Gln Gln His Glu Thr 
        435                 440                 445             


Ala Ser Gln Thr Ser Phe Pro Asp Val Tyr Asn Glu Gly Thr Gln Ala 
    450                 455                 460                 


Val Thr Glu Glu Asn Ile Ala Ser Leu Gln Lys Arg Val Val Glu Leu 
465                 470                 475                 480 


Glu Asn Glu Lys Gly Ala Leu Leu Leu Ser Ser Ile Glu Leu Glu Glu 
                485                 490                 495     


Leu Lys Ala Glu Asn Glu Lys Leu Ser Ser Gln Ile Thr Leu Leu Glu 
            500                 505                 510         


Ala Gln Asn Arg Thr Gly Glu Ala Asp Arg Glu Val Ser Glu Ile Ser 
        515                 520                 525             


Ile Val Asp Ile Ala Asn Lys Arg Ser Ser Ser Ala Glu Glu Ser Gly 
    530                 535                 540                 


Gln Asp Val Leu Glu Asn Thr Phe Ser Gln Lys His Lys Glu Leu Ser 
545                 550                 555                 560 


Val Leu Leu Leu Glu Met Lys Glu Ala Gln Glu Glu Ile Ala Phe Leu 
                565                 570                 575     


Lys Leu Gln Leu Gln Gly Lys Arg Ala Glu Glu Ala Asp His Glu Val 
            580                 585                 590         


Leu Asp Gln Lys Glu Met Lys Gln Met Glu Gly Glu Gly Ile Ala Pro 
        595                 600                 605             


Ile Lys Met Lys Val Phe Leu Glu Asp Thr Gly Gln Asp Phe Pro Leu 
    610                 615                 620                 


Met Pro Asn Glu Glu Ser Ser Leu Pro Ala Val Glu Lys Glu Gln Ala 
625                 630                 635                 640 


Ser Thr Glu His Gln Ser Arg Thr Ser Glu Glu Ile Ser Leu Asn Asp 
                645                 650                 655     


Ala Gly Val Glu Leu Lys Ser Thr Lys Gln Asp Gly Asp Lys Ser Leu 
            660                 665                 670         


Ser Ala Val Pro Asp Ile Gly Gln Cys His Gln Asp Glu Leu Glu Arg 
        675                 680                 685             


Leu Lys Ser Gln Ile Leu Glu Leu Glu Leu Asn Phe His Lys Ala Gln 
    690                 695                 700                 


Glu Ile Tyr Glu Lys Asn Leu Asp Glu Lys Ala Lys Glu Ile Ser Asn 
705                 710                 715                 720 


Leu Asn Gln Leu Ile Glu Glu Phe Lys Lys Asn Ala Asp Asn Asn Ser 
                725                 730                 735     


Ser Ala Phe Thr Ala Leu Ser Glu Glu Arg Asp Gln Leu Leu Ser Gln 
            740                 745                 750         


Val Lys Glu Leu Ser Met Val Thr Glu Leu Arg Ala Gln Val Lys Gln 
        755                 760                 765             


Leu Glu Met Asn Leu Ala Glu Ala Glu Arg Gln Arg Arg Leu Asp Tyr 
    770                 775                 780                 


Glu Ser Gln Thr Ala His Asp Asn Leu Leu Thr Glu Gln Ile His Ser 
785                 790                 795                 800 


Leu Ser Ile Glu Ala Lys Ser Lys Asp Val Lys Ile Glu Val Leu Gln 
                805                 810                 815     


Asn Glu Leu Asp Asp Val Gln Leu Gln Phe Ser Glu Gln Ser Thr Leu 
            820                 825                 830         


Ile Arg Ser Leu Gln Ser Gln Leu Gln Asn Lys Glu Ser Glu Val Leu 
        835                 840                 845             


Glu Gly Ala Glu Arg Val Arg His Ile Ser Ser Lys Val Glu Glu Leu 
    850                 855                 860                 


Ser Gln Ala Leu Ser Gln Lys Glu Leu Glu Ile Thr Lys Met Asp Gln 
865                 870                 875                 880 


Leu Leu Leu Glu Lys Lys Arg Asp Val Glu Thr Leu Gln Gln Thr Ile 
                885                 890                 895     


Glu Glu Lys Asp Gln Gln Val Thr Glu Ile Ser Phe Ser Met Thr Glu 
            900                 905                 910         


Lys Met Val Gln Leu Asn Glu Glu Lys Phe Ser Leu Gly Val Glu Ile 
        915                 920                 925             


Lys Thr Leu Lys Glu Gln Leu Asn Leu Leu Ser Arg Ala Glu Glu Ala 
    930                 935                 940                 


Lys Lys Glu Gln Val Glu Glu Asp Asn Glu Val Ser Ser Gly Leu Lys 
945                 950                 955                 960 


Gln Asn Tyr Asp Glu Met Ser Pro Ala Gly Gln Ile Ser Lys Glu Glu 
                965                 970                 975     


Leu Gln His Glu Phe Asp Leu Leu Lys Lys Glu Asn Glu Gln Arg Lys 
            980                 985                 990         


Arg Lys Leu Gln Ala Ala Leu Ile  Asn Arg Lys Glu Leu  Leu Gln Arg 
        995                 1000                 1005             


Val Ser  Arg Leu Glu Glu Glu  Leu Ala Asn Leu Lys  Asp Glu Ser 
    1010                 1015                 1020             


Lys Lys  Glu Ile Pro Leu Ser  Glu Thr Glu Arg Gly  Glu Val Glu 
    1025                 1030                 1035             


Glu Asp  Lys Glu Asn Lys Glu  Tyr Ser Glu Lys Cys  Val Thr Ser 
    1040                 1045                 1050             


Lys Cys  Gln Glu Ile Glu Ile  Tyr Leu Lys Gln Thr  Ile Ser Glu 
    1055                 1060                 1065             


Lys Glu  Val Glu Leu Gln His  Ile Arg Lys Asp Leu  Glu Glu Lys 
    1070                 1075                 1080             


Leu Ala  Ala Glu Glu Gln Phe  Gln Ala Leu Val Lys  Gln Met Asn 
    1085                 1090                 1095             


Gln Thr  Leu Gln Asp Lys Thr  Asn Gln Ile Asp Leu  Leu Gln Ala 
    1100                 1105                 1110             


Glu Ile  Ser Glu Asn Gln Ala  Ile Ile Gln Lys Leu  Ile Thr Ser 
    1115                 1120                 1125             


Asn Thr  Asp Ala Ser Asp Gly  Asp Ser Val Ala Leu  Val Lys Glu 
    1130                 1135                 1140             


Thr Val  Val Ile Ser Pro Pro  Cys Thr Gly Ser Ser  Glu His Trp 
    1145                 1150                 1155             


Lys Pro  Glu Leu Glu Glu Lys  Ile Leu Ala Leu Glu  Lys Glu Lys 
    1160                 1165                 1170             


Glu Gln  Leu Gln Lys Lys Leu  Gln Glu Ala Leu Thr  Ser Arg Lys 
    1175                 1180                 1185             


Ala Ile  Leu Lys Lys Ala Gln  Glu Lys Glu Arg His  Leu Arg Glu 
    1190                 1195                 1200             


Glu Leu  Lys Gln Gln Lys Asp  Asp Tyr Asn Arg Leu  Gln Glu Gln 
    1205                 1210                 1215             


Phe Asp  Glu Gln Ser Lys Glu  Asn Glu Asn Ile Gly  Asp Gln Leu 
    1220                 1225                 1230             


Arg Gln  Leu Gln Ile Gln Val  Arg Glu Ser Ile Asp  Gly Lys Leu 
    1235                 1240                 1245             


Pro Ser  Thr Asp Gln Gln Glu  Ser Cys Ser Ser Thr  Pro Gly Leu 
    1250                 1255                 1260             


Glu Glu  Pro Leu Phe Lys Ala  Thr Glu Gln His His  Thr Gln Pro 
    1265                 1270                 1275             


Val Leu  Glu Ser Asn Leu Cys  Pro Asp Trp Pro Ser  His Ser Glu 
    1280                 1285                 1290             


Asp Ala  Ser Ala Leu Gln Gly  Gly Thr Ser Val Ala  Gln Ile Lys 
    1295                 1300                 1305             


Ala Gln  Leu Lys Glu Ile Glu  Ala Glu Lys Val Glu  Leu Glu Leu 
    1310                 1315                 1320             


Lys Val  Ser Ser Thr Thr Ser  Glu Leu Thr Lys Lys  Ser Glu Glu 
    1325                 1330                 1335             


Val Phe  Gln Leu Gln Glu Gln  Ile Asn Lys Gln Gly  Leu Glu Ile 
    1340                 1345                 1350             


Glu Ser  Leu Lys Thr Val Ser  His Glu Ala Glu Val  His Ala Glu 
    1355                 1360                 1365             


Ser Leu  Gln Gln Lys Leu Glu  Ser Ser Gln Leu Gln  Ile Ala Gly 
    1370                 1375                 1380             


Leu Glu  His Leu Arg Glu Leu  Gln Pro Lys Leu Asp  Glu Leu Gln 
    1385                 1390                 1395             


Lys Leu  Ile Ser Lys Lys Glu  Glu Asp Val Ser Tyr  Leu Ser Gly 
    1400                 1405                 1410             


Gln Leu  Ser Glu Lys Glu Ala  Ala Leu Thr Lys Ile  Gln Thr Glu 
    1415                 1420                 1425             


Ile Ile  Glu Gln Glu Asp Leu  Ile Lys Ala Leu His  Thr Gln Leu 
    1430                 1435                 1440             


Glu Met  Gln Ala Lys Glu His  Asp Glu Arg Ile Lys  Gln Leu Gln 
    1445                 1450                 1455             


Val Glu  Leu Cys Glu Met Lys  Gln Lys Pro Glu Glu  Ile Gly Glu 
    1460                 1465                 1470             


Glu Ser  Arg Ala Lys Gln Gln  Ile Gln Arg Lys Leu  Gln Ala Ala 
    1475                 1480                 1485             


Leu Ile  Ser Arg Lys Glu Ala  Leu Lys Glu Asn Lys  Ser Leu Gln 
    1490                 1495                 1500             


Glu Glu  Leu Ser Leu Ala Arg  Gly Thr Ile Glu Arg  Leu Thr Lys 
    1505                 1510                 1515             


Ser Leu  Ala Asp Val Glu Ser  Gln Val Ser Ala Gln  Asn Lys Glu 
    1520                 1525                 1530             


Lys Asp  Thr Val Leu Gly Arg  Leu Ala Leu Leu Gln  Glu Glu Arg 
    1535                 1540                 1545             


Asp Lys  Leu Ile Thr Glu Met  Asp Arg Ser Leu Leu  Glu Asn Gln 
    1550                 1555                 1560             


Ser Leu  Ser Ser Ser Cys Glu  Ser Leu Lys Leu Ala  Leu Glu Gly 
    1565                 1570                 1575             


Leu Thr  Glu Asp Lys Glu Lys  Leu Val Lys Glu Ile  Glu Ser Leu 
    1580                 1585                 1590             


Lys Ser  Ser Lys Ile Ala Glu  Ser Thr Glu Trp Gln  Glu Lys His 
    1595                 1600                 1605             


Lys Glu  Leu Gln Lys Glu Tyr  Glu Ile Leu Leu Gln  Ser Tyr Glu 
    1610                 1615                 1620             


Asn Val  Ser Asn Glu Ala Glu  Arg Ile Gln His Val  Val Glu Ala 
    1625                 1630                 1635             


Val Arg  Gln Glu Lys Gln Glu  Leu Tyr Gly Lys Leu  Arg Ser Thr 
    1640                 1645                 1650             


Glu Ala  Asn Lys Lys Glu Thr  Glu Lys Gln Leu Gln  Glu Ala Glu 
    1655                 1660                 1665             


Gln Glu  Met Glu Glu Met Lys  Glu Lys Met Arg Lys  Phe Ala Lys 
    1670                 1675                 1680             


Ser Lys  Gln Gln Lys Ile Leu  Glu Leu Glu Glu Glu  Asn Asp Arg 
    1685                 1690                 1695             


Leu Arg  Ala Glu Val His Pro  Ala Gly Asp Thr Ala  Lys Glu Cys 
    1700                 1705                 1710             


Met Glu  Thr Leu Leu Ser Ser  Asn Ala Ser Met Lys  Glu Glu Leu 
    1715                 1720                 1725             


Glu Arg  Val Lys Met Glu Tyr  Glu Thr Leu Ser Lys  Lys Phe Gln 
    1730                 1735                 1740             


Ser Leu  Met Ser Glu Lys Asp  Ser Leu Ser Glu Glu  Val Gln Asp 
    1745                 1750                 1755             


Leu Lys  His Gln Ile Glu Gly  Asn Val Ser Lys Gln  Ala Asn Leu 
    1760                 1765                 1770             


Glu Ala  Thr Glu Lys His Asp  Asn Gln Thr Asn Val  Thr Glu Glu 
    1775                 1780                 1785             


Gly Thr  Gln Ser Ile Pro Gly  Glu Thr Glu Glu Gln  Asp Ser Leu 
    1790                 1795                 1800             


Ser Met  Ser Thr Arg Pro Thr  Cys Ser Glu Ser Val  Pro Ser Ala 
    1805                 1810                 1815             


Lys Ser  Ala Asn Pro Ala Val  Ser Lys Asp Phe Ser  Ser His Asp 
    1820                 1825                 1830             


Glu Ile  Asn Asn Tyr Leu Gln  Gln Ile Asp Gln Leu  Lys Glu Arg 
    1835                 1840                 1845             


Ile Ala  Gly Leu Glu Glu Glu  Lys Gln Lys Asn Lys  Glu Phe Ser 
    1850                 1855                 1860             


Gln Thr  Leu Glu Asn Glu Lys  Asn Thr Leu Leu Ser  Gln Ile Ser 
    1865                 1870                 1875             


Thr Lys  Asp Gly Glu Leu Lys  Met Leu Gln Glu Glu  Val Thr Lys 
    1880                 1885                 1890             


Met Asn  Leu Leu Asn Gln Gln  Ile Gln Glu Glu Leu  Ser Arg Val 
    1895                 1900                 1905             


Thr Lys  Leu Lys Glu Thr Ala  Glu Glu Glu Lys Asp  Asp Leu Glu 
    1910                 1915                 1920             


Glu Arg  Leu Met Asn Gln Leu  Ala Glu Leu Asn Gly  Ser Ile Gly 
    1925                 1930                 1935             


Asn Tyr  Cys Gln Asp Val Thr  Asp Ala Gln Ile Lys  Asn Glu Leu 
    1940                 1945                 1950             


Leu Glu  Ser Glu Met Lys Asn  Leu Lys Lys Cys Val  Ser Glu Leu 
    1955                 1960                 1965             


Glu Glu  Glu Lys Gln Gln Leu  Val Lys Glu Lys Thr  Lys Val Glu 
    1970                 1975                 1980             


Ser Glu  Ile Arg Lys Glu Tyr  Leu Glu Lys Ile Gln  Gly Ala Gln 
    1985                 1990                 1995             


Lys Glu  Pro Gly Asn Lys Ser  His Ala Lys Glu Leu  Gln Glu Leu 
    2000                 2005                 2010             


Leu Lys  Glu Lys Gln Gln Glu  Val Lys Gln Leu Gln  Lys Asp Cys 
    2015                 2020                 2025             


Ile Arg  Tyr Gln Glu Lys Ile  Ser Ala Leu Glu Arg  Thr Val Lys 
    2030                 2035                 2040             


Ala Leu  Glu Phe Val Gln Thr  Glu Ser Gln Lys Asp  Leu Glu Ile 
    2045                 2050                 2055             


Thr Lys  Glu Asn Leu Ala Gln  Ala Val Glu His Arg  Lys Lys Ala 
    2060                 2065                 2070             


Gln Ala  Glu Leu Ala Ser Phe  Lys Val Leu Leu Asp  Asp Thr Gln 
    2075                 2080                 2085             


Ser Glu  Ala Ala Arg Val Leu  Ala Asp Asn Leu Lys  Leu Lys Lys 
    2090                 2095                 2100             


Glu Leu  Gln Ser Asn Lys Glu  Ser Val Lys Ser Gln  Met Lys Gln 
    2105                 2110                 2115             


Lys Asp  Glu Asp Leu Glu Arg  Arg Leu Glu Gln Ala  Glu Glu Lys 
    2120                 2125                 2130             


His Leu  Lys Glu Lys Lys Asn  Met Gln Glu Lys Leu  Asp Ala Leu 
    2135                 2140                 2145             


Arg Arg  Glu Lys Val His Leu  Glu Glu Thr Ile Gly  Glu Ile Gln 
    2150                 2155                 2160             


Val Thr  Leu Asn Lys Lys Asp  Lys Glu Val Gln Gln  Leu Gln Glu 
    2165                 2170                 2175             


Asn Leu  Asp Ser Thr Val Thr  Gln Leu Ala Ala Phe  Thr Lys Ser 
    2180                 2185                 2190             


Met Ser  Ser Leu Gln Asp Asp  Arg Asp Arg Val Ile  Asp Glu Ala 
    2195                 2200                 2205             


Lys Lys  Trp Glu Arg Lys Phe  Ser Asp Ala Ile Gln  Ser Lys Glu 
    2210                 2215                 2220             


Glu Glu  Ile Arg Leu Lys Glu  Asp Asn Cys Ser Val  Leu Lys Asp 
    2225                 2230                 2235             


Gln Leu  Arg Gln Met Ser Ile  His Met Glu Glu Leu  Lys Ile Asn 
    2240                 2245                 2250             


Ile Ser  Arg Leu Glu His Asp  Lys Gln Ile Trp Glu  Ser Lys Ala 
    2255                 2260                 2265             


Gln Thr  Glu Val Gln Leu Gln  Gln Lys Val Cys Asp  Thr Leu Gln 
    2270                 2275                 2280             


Gly Glu  Asn Lys Glu Leu Leu  Ser Gln Leu Glu Glu  Thr Arg His 
    2285                 2290                 2295             


Leu Tyr  His Ser Ser Gln Asn  Glu Leu Ala Lys Leu  Glu Ser Glu 
    2300                 2305                 2310             


Leu Lys  Ser Leu Lys Asp Gln  Leu Thr Asp Leu Ser  Asn Ser Leu 
    2315                 2320                 2325             


Glu Lys  Cys Lys Glu Gln Lys  Gly Asn Leu Glu Gly  Ile Ile Arg 
    2330                 2335                 2340             


Gln Gln  Glu Ala Asp Ile Gln  Asn Ser Lys Phe Ser  Tyr Glu Gln 
    2345                 2350                 2355             


Leu Glu  Thr Asp Leu Gln Ala  Ser Arg Glu Leu Thr  Ser Arg Leu 
    2360                 2365                 2370             


His Glu  Glu Ile Asn Met Lys  Glu Gln Lys Ile Ile  Ser Leu Leu 
    2375                 2380                 2385             


Ser Gly  Lys Glu Glu Ala Ile  Gln Val Ala Ile Ala  Glu Leu Arg 
    2390                 2395                 2400             


Gln Gln  His Asp Lys Glu Ile  Lys Glu Leu Glu Asn  Leu Leu Ser 
    2405                 2410                 2415             


Gln Glu  Glu Glu Glu Asn Ile  Val Leu Glu Glu Glu  Asn Lys Lys 
    2420                 2425                 2430             


Ala Val  Asp Lys Thr Asn Gln  Leu Met Glu Thr Leu  Lys Thr Ile 
    2435                 2440                 2445             


Lys Lys  Glu Asn Ile Gln Gln  Lys Ala Gln Leu Asp  Ser Phe Val 
    2450                 2455                 2460             


Lys Ser  Met Ser Ser Leu Gln  Asn Asp Arg Asp Arg  Ile Val Gly 
    2465                 2470                 2475             


Asp Tyr  Gln Gln Leu Glu Glu  Arg His Leu Ser Ile  Ile Leu Glu 
    2480                 2485                 2490             


Lys Asp  Gln Leu Ile Gln Glu  Ala Ala Ala Glu Asn  Asn Lys Leu 
    2495                 2500                 2505             


Lys Glu  Glu Ile Arg Gly Leu  Arg Ser His Met Asp  Asp Leu Asn 
    2510                 2515                 2520             


Ser Glu  Asn Ala Lys Leu Asp  Ala Glu Leu Ile Gln  Tyr Arg Glu 
    2525                 2530                 2535             


Asp Leu  Asn Gln Val Ile Thr  Ile Lys Asp Ser Gln  Gln Lys Gln 
    2540                 2545                 2550             


Leu Leu  Glu Val Gln Leu Gln  Gln Asn Lys Glu Leu  Glu Asn Lys 
    2555                 2560                 2565             


Tyr Ala  Lys Leu Glu Glu Lys  Leu Lys Glu Ser Glu  Glu Ala Asn 
    2570                 2575                 2580             


Glu Asp  Leu Arg Arg Ser Phe  Asn Ala Leu Gln Glu  Glu Lys Gln 
    2585                 2590                 2595             


Asp Leu  Ser Lys Glu Ile Glu  Ser Leu Lys Val Ser  Ile Ser Gln 
    2600                 2605                 2610             


Leu Thr  Arg Gln Val Thr Ala  Leu Gln Glu Glu Gly  Thr Leu Gly 
    2615                 2620                 2625             


Leu Tyr  His Ala Gln Leu Lys  Val Lys Glu Glu Glu  Val His Arg 
    2630                 2635                 2640             


Leu Ser  Ala Leu Phe Ser Ser  Ser Gln Lys Arg Ile  Ala Glu Leu 
    2645                 2650                 2655             


Glu Glu  Glu Leu Val Cys Val  Gln Lys Glu Ala Ala  Lys Lys Val 
    2660                 2665                 2670             


Gly Glu  Ile Glu Asp Lys Leu  Lys Lys Glu Leu Lys  His Leu His 
    2675                 2680                 2685             


His Asp  Ala Gly Ile Met Arg  Asn Glu Thr Glu Thr  Ala Glu Glu 
    2690                 2695                 2700             


Arg Val  Ala Glu Leu Ala Arg  Asp Leu Val Glu Met  Glu Gln Lys 
    2705                 2710                 2715             


Leu Leu  Met Val Thr Lys Glu  Asn Lys Gly Leu Thr  Ala Gln Ile 
    2720                 2725                 2730             


Gln Ser  Phe Gly Arg Ser Met  Ser Ser Leu Gln Asn  Ser Arg Asp 
    2735                 2740                 2745             


His Ala  Asn Glu Glu Leu Asp  Glu Leu Lys Arg Lys  Tyr Asp Ala 
    2750                 2755                 2760             


Ser Leu  Lys Glu Leu Ala Gln  Leu Lys Glu Gln Gly  Leu Leu Asn 
    2765                 2770                 2775             


Arg Glu  Arg Asp Ala Leu Leu  Ser Glu Thr Ala Phe  Ser Met Asn 
    2780                 2785                 2790             


Ser Thr  Glu Glu Asn Ser Leu  Ser His Leu Glu Lys  Leu Asn Gln 
    2795                 2800                 2805             


Gln Leu  Leu Ser Lys Asp Glu  Gln Leu Leu His Leu  Ser Ser Gln 
    2810                 2815                 2820             


Leu Glu  Asp Ser Tyr Asn Gln  Val Gln Ser Phe Ser  Lys Ala Met 
    2825                 2830                 2835             


Ala Ser  Leu Gln Asn Glu Arg  Asp His Leu Trp Asn  Glu Leu Glu 
    2840                 2845                 2850             


Lys Phe  Arg Lys Ser Glu Glu  Gly Lys Gln Arg Ser  Ala Ala Gln 
    2855                 2860                 2865             


Pro Ser  Thr Ser Pro Ala Glu  Val Gln Ser Leu Lys  Lys Ala Met 
    2870                 2875                 2880             


Ser Ser  Leu Gln Asn Asp Arg  Asp Arg Leu Leu Lys  Glu Leu Lys 
    2885                 2890                 2895             


Asn Leu  Gln Gln Gln Tyr Leu  Gln Ile Asn Gln Glu  Ile Thr Glu 
    2900                 2905                 2910             


Leu His  Pro Leu Lys Ala Gln  Leu Gln Glu Tyr Gln  Asp Lys Thr 
    2915                 2920                 2925             


Lys Ala  Phe Gln Ile Met Gln  Glu Glu Leu Arg Gln  Glu Asn Leu 
    2930                 2935                 2940             


Ser Trp  Gln His Glu Leu His  Gln Leu Arg Met Glu  Lys Ser Ser 
    2945                 2950                 2955             


Trp Glu  Ile His Glu Arg Arg  Met Lys Glu Gln Tyr  Leu Met Ala 
    2960                 2965                 2970             


Ile Ser  Asp Lys Asp Gln Gln  Leu Ser His Leu Gln  Asn Leu Ile 
    2975                 2980                 2985             


Arg Glu  Leu Arg Ser Ser Ser  Ser Gln Thr Gln Pro  Leu Lys Val 
    2990                 2995                 3000             


Gln Tyr  Gln Arg Gln Ala Ser  Pro Glu Thr Ser Ala  Ser Pro Asp 
    3005                 3010                 3015             


Gly Ser  Gln Asn Leu Val Tyr  Glu Thr Glu Leu Leu  Arg Thr Gln 
    3020                 3025                 3030             


Leu Asn  Asp Ser Leu Lys Glu  Ile His Gln Lys Glu  Leu Arg Ile 
    3035                 3040                 3045             


Gln Gln  Leu Asn Ser Asn Phe  Ser Gln Leu Leu Glu  Glu Lys Asn 
    3050                 3055                 3060             


Thr Leu  Ser Ile Gln Leu Cys  Asp Thr Ser Gln Ser  Leu Arg Glu 
    3065                 3070                 3075             


Asn Gln  Gln His Tyr Gly Asp  Leu Leu Asn His Cys  Ala Val Leu 
    3080                 3085                 3090             


Glu Lys  Gln Val Gln Glu Leu  Gln Ala Gly Pro Leu  Asn Ile Asp 
    3095                 3100                 3105             


Val Ala  Pro Gly Ala Pro Gln  Glu Lys Asn Gly Val  His Arg Lys 
    3110                 3115                 3120             


Ser Asp  Pro Glu Glu Leu Arg  Glu Pro Gln Gln Ser  Phe Ser Glu 
    3125                 3130                 3135             


Ala Gln  Gln Gln Leu Cys Asn  Thr Arg Gln Glu Val  Asn Glu Leu 
    3140                 3145                 3150             


Arg Lys  Leu Leu Glu Glu Glu  Arg Asp Gln Arg Val  Ala Ala Glu 
    3155                 3160                 3165             


Asn Ala  Leu Ser Val Ala Glu  Glu Gln Ile Arg Arg  Leu Glu His 
    3170                 3175                 3180             


Ser Glu  Trp Asp Ser Ser Arg  Thr Pro Ile Ile Gly  Ser Cys Gly 
    3185                 3190                 3195             


Thr Gln  Glu Gln Ala Leu Leu  Ile Asp Leu Thr Ser  Asn Ser Cys 
    3200                 3205                 3210             


Arg Arg  Thr Arg Ser Gly Val  Gly Trp Lys Arg Val  Leu Arg Ser 
    3215                 3220                 3225             


Leu Cys  His Ser Arg Thr Arg  Val Pro Leu Leu Ala  Ala Ile Tyr 
    3230                 3235                 3240             


Phe Leu  Met Ile His Val Leu  Leu Ile Leu Cys Phe  Thr Gly His 
    3245                 3250                 3255             


Leu 
    


<210>  35
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Leu Leu Ser Arg Pro Ala Leu Thr Leu Leu Leu Leu Leu Met 
1               5                   10                  15      


Ala Ala Val Val Arg Cys Gln Glu Gln Ala Gln Thr Thr Asp Trp Arg 
            20                  25                  30          


Ala Thr Leu Lys Thr Ile Arg Asn Gly Val His Lys Ile Asp Thr Tyr 
        35                  40                  45              


Leu Asn Ala Ala Leu Asp Leu Leu Gly Gly Glu Asp Gly Leu Cys Gln 
    50                  55                  60                  


Tyr Lys Cys Ser Asp Gly Ser Lys Pro Phe Pro Arg Tyr Gly Tyr Lys 
65                  70                  75                  80  


Pro Ser Pro Pro Asn Gly Cys Gly Ser Pro Leu Phe Gly Val His Leu 
                85                  90                  95      


Asn Ile Gly Ile Pro Ser Leu Thr Lys Cys Cys Asn Gln His Asp Arg 
            100                 105                 110         


Cys Tyr Glu Thr Cys Gly Lys Ser Lys Asn Asp Cys Asp Glu Glu Phe 
        115                 120                 125             


Gln Tyr Cys Leu Ser Lys Ile Cys Arg Asp Val Gln Lys Thr Leu Gly 
    130                 135                 140                 


Leu Thr Gln His Val Gln Ala Cys Glu Thr Thr Val Glu Leu Leu Phe 
145                 150                 155                 160 


Asp Ser Val Ile His Leu Gly Cys Lys Pro Tyr Leu Asp Ser Gln Arg 
                165                 170                 175     


Ala Ala Cys Arg Cys His Tyr Glu Glu Lys Thr Asp Leu 
            180                 185                 


<210>  36
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Thr Val His Glu Ile Leu Cys Lys Leu Ser Leu Glu Gly Asp 
1               5                   10                  15      


His Ser Thr Pro Pro Ser Ala Tyr Gly Ser Val Lys Ala Tyr Thr Asn 
            20                  25                  30          


Phe Asp Ala Glu Arg Asp Ala Leu Asn Ile Glu Thr Ala Ile Lys Thr 
        35                  40                  45              


Lys Gly Val Asp Glu Val Thr Ile Val Asn Ile Leu Thr Asn Arg Ser 
    50                  55                  60                  


Asn Ala Gln Arg Gln Asp Ile Ala Phe Ala Tyr Gln Arg Arg Thr Lys 
65                  70                  75                  80  


Lys Glu Leu Ala Ser Ala Leu Lys Ser Ala Leu Ser Gly His Leu Glu 
                85                  90                  95      


Thr Val Ile Leu Gly Leu Leu Lys Thr Pro Ala Gln Tyr Asp Ala Ser 
            100                 105                 110         


Glu Leu Lys Ala Ser Met Lys Gly Leu Gly Thr Asp Glu Asp Ser Leu 
        115                 120                 125             


Ile Glu Ile Ile Cys Ser Arg Thr Asn Gln Glu Leu Gln Glu Ile Asn 
    130                 135                 140                 


Arg Val Tyr Lys Glu Met Tyr Lys Thr Asp Leu Glu Lys Asp Ile Ile 
145                 150                 155                 160 


Ser Asp Thr Ser Gly Asp Phe Arg Lys Leu Met Val Ala Leu Ala Lys 
                165                 170                 175     


Gly Arg Arg Ala Glu Asp Gly Ser Val Ile Asp Tyr Glu Leu Ile Asp 
            180                 185                 190         


Gln Asp Ala Arg Asp Leu Tyr Asp Ala Gly Val Lys Arg Lys Gly Thr 
        195                 200                 205             


Asp Val Pro Lys Trp Ile Ser Ile Met Thr Glu Arg Ser Val Pro His 
    210                 215                 220                 


Leu Gln Lys Val Phe Asp Arg Tyr Lys Ser Tyr Ser Pro Tyr Asp Met 
225                 230                 235                 240 


Leu Glu Ser Ile Arg Lys Glu Val Lys Gly Asp Leu Glu Asn Ala Phe 
                245                 250                 255     


Leu Asn Leu Val Gln Cys Ile Gln Asn Lys Pro Leu Tyr Phe Ala Asp 
            260                 265                 270         


Arg Leu Tyr Asp Ser Met Lys Gly Lys Gly Thr Arg Asp Lys Val Leu 
        275                 280                 285             


Ile Arg Ile Met Val Ser Arg Ser Glu Val Asp Met Leu Lys Ile Arg 
    290                 295                 300                 


Ser Glu Phe Lys Arg Lys Tyr Gly Lys Ser Leu Tyr Tyr Tyr Ile Gln 
305                 310                 315                 320 


Gln Asp Thr Lys Gly Asp Tyr Gln Lys Ala Leu Leu Tyr Leu Cys Gly 
                325                 330                 335     


Gly Asp Asp 
            


<210>  37
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe 
1               5                   10                  15      


Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro 
            20                  25                  30          


Phe Ser Ile Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly 
        35                  40                  45              


Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu 
    50                  55                  60                  


Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg 
65                  70                  75                  80  


Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys 
                85                  90                  95      


Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr 
            100                 105                 110         


Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala 
        115                 120                 125             


Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile 
    130                 135                 140                 


Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met 
                165                 170                 175     


Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg 
            180                 185                 190         


Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr 
        195                 200                 205             


Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu 
    210                 215                 220                 


Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His 
                245                 250                 255     


Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser 
            260                 265                 270         


Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu 
        275                 280                 285             


Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu 
    290                 295                 300                 


Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His 
305                 310                 315                 320 


Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala 
                325                 330                 335     


Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe 
            340                 345                 350         


Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly 
        355                 360                 365             


Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro 
    370                 375                 


<210>  38
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Asn Lys Pro Ile Thr Pro Ser Thr Tyr Val Arg Cys Leu Asn Val 
1               5                   10                  15      


Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp Pro Gln Glu Gly Trp 
            20                  25                  30          


Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser Gly Asp Asp Arg Tyr 
        35                  40                  45              


Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu Leu Gln Thr Gly Lys 
    50                  55                  60                  


Ser Pro Thr Ser Glu Leu Leu Phe Asp Trp Gly Thr Thr Asn Cys Thr 
65                  70                  75                  80  


Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn Glu Phe Phe Ala Pro 
                85                  90                  95      


Ala Ser Leu Leu Leu Pro Asp Ala Val Pro Lys Thr Ala Asn Thr Leu 
            100                 105                 110         


Pro Ser Lys Glu Ala Ile Thr Val Gln Gln Lys Gln Met Pro Phe Cys 
        115                 120                 125             


Asp Lys Asp Arg Thr Leu Met Thr Pro Val Gln Asn Leu Glu Gln Ser 
    130                 135                 140                 


Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn Lys Ser Leu Glu Val 
145                 150                 155                 160 


Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr Glu Leu Lys Asn Val 
                165                 170                 175     


Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Val Gly Gly Asn Lys Met 
            180                 185                 190         


Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly Tyr Val Asn Asn Thr 
        195                 200                 205             


Thr Val Ala Val Lys Lys Leu Ala Ala Met Val Asp Ile Thr Thr Glu 
    210                 215                 220                 


Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys Val Met Ala Lys Cys 
225                 230                 235                 240 


Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe Ser Ser Asp Gly Asp 
                245                 250                 255     


Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn Gly Ser Leu Leu Asp 
            260                 265                 270         


Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu Ser Trp His Met Arg 
        275                 280                 285             


Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile Asn Phe Leu His Glu 
    290                 295                 300                 


Asn His His Ile His Arg Asp Ile Lys Ser Ala Asn Ile Leu Leu Asp 
305                 310                 315                 320 


Glu Ala Phe Thr Ala Lys Ile Ser Asp Phe Gly Leu Ala Arg Ala Ser 
                325                 330                 335     


Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg Ile Val Gly Thr Thr 
            340                 345                 350         


Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu Ile Thr Pro Lys Ser 
        355                 360                 365             


Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu Ile Ile Thr Gly Leu 
    370                 375                 380                 


Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu Leu Leu Asp Ile Lys 
385                 390                 395                 400 


Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu Asp Tyr Ile Asp Lys 
                405                 410                 415     


Lys Met Asn Asp Ala Asp Ser Thr Ser Val Glu Ala Met Tyr Ser Val 
            420                 425                 430         


Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys Arg Pro Asp Ile Lys 
        435                 440                 445             


Lys Val Gln Gln Leu Leu Gln Glu Met Thr Ala Ser 
    450                 455                 460 


<210>  39
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Asp Tyr Ser Thr Val Pro Pro Pro Ser Ser Gly Ser Ala Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Asn Asp Ala Phe Lys 
            20                  25                  30          


Asp Ala Leu Gln Arg Ala Arg Gln Ile Ala Ala Lys Ile Gly Gly Asp 
        35                  40                  45              


Ala Gly Thr Ser Leu Asn Ser Asn Asp Tyr Gly Tyr Gly Gly Gln Lys 
    50                  55                  60                  


Arg Pro Leu Glu Asp Gly Asp Gln Pro Asp Ala Lys Lys Val Ala Pro 
65                  70                  75                  80  


Gln Asn Asp Ser Phe Gly Thr Gln Leu Pro Pro Met His Gln Gln Gln 
                85                  90                  95      


Ser Arg Ser Val Met Thr Glu Glu Tyr Lys Val Pro Asp Gly Met Val 
            100                 105                 110         


Gly Phe Ile Ile Gly Arg Gly Gly Glu Gln Ile Ser Arg Ile Gln Gln 
        115                 120                 125             


Glu Ser Gly Cys Lys Ile Gln Ile Ala Pro Asp Ser Gly Gly Leu Pro 
    130                 135                 140                 


Glu Arg Ser Cys Met Leu Thr Gly Thr Pro Glu Ser Val Gln Ser Ala 
145                 150                 155                 160 


Lys Arg Leu Leu Asp Gln Ile Val Glu Lys Gly Arg Pro Ala Pro Gly 
                165                 170                 175     


Phe His His Gly Asp Gly Pro Gly Asn Ala Val Gln Glu Ile Met Ile 
            180                 185                 190         


Pro Ala Ser Lys Ala Gly Leu Val Ile Gly Lys Gly Gly Glu Thr Ile 
        195                 200                 205             


Lys Gln Leu Gln Glu Arg Ala Gly Val Lys Met Val Met Ile Gln Asp 
    210                 215                 220                 


Gly Pro Gln Asn Thr Gly Ala Asp Lys Pro Leu Arg Ile Thr Gly Asp 
225                 230                 235                 240 


Pro Tyr Lys Val Gln Gln Ala Lys Glu Met Val Leu Glu Leu Ile Arg 
                245                 250                 255     


Asp Gln Gly Gly Phe Arg Glu Val Arg Asn Glu Tyr Gly Ser Arg Ile 
            260                 265                 270         


Gly Gly Asn Glu Gly Ile Asp Val Pro Ile Pro Arg Phe Ala Val Gly 
        275                 280                 285             


Ile Val Ile Gly Arg Asn Gly Glu Met Ile Lys Lys Ile Gln Asn Asp 
    290                 295                 300                 


Ala Gly Val Arg Ile Gln Phe Lys Pro Asp Asp Gly Thr Thr Pro Glu 
305                 310                 315                 320 


Arg Ile Ala Gln Ile Thr Gly Pro Pro Asp Arg Cys Gln His Ala Ala 
                325                 330                 335     


Glu Ile Ile Thr Asp Leu Leu Arg Ser Val Gln Ala Gly Asn Pro Gly 
            340                 345                 350         


Gly Pro Gly Pro Gly Gly Arg Gly Arg Gly Arg Gly Gln Gly Asn Trp 
        355                 360                 365             


Asn Met Gly Pro Pro Gly Gly Leu Gln Glu Phe Asn Phe Ile Val Pro 
    370                 375                 380                 


Thr Gly Lys Thr Gly Leu Ile Ile Gly Lys Gly Gly Glu Thr Ile Lys 
385                 390                 395                 400 


Ser Ile Ser Gln Gln Ser Gly Ala Arg Ile Glu Leu Gln Arg Asn Pro 
                405                 410                 415     


Pro Pro Asn Ala Asp Pro Asn Met Lys Leu Phe Thr Ile Arg Gly Thr 
            420                 425                 430         


Pro Gln Gln Ile Asp Tyr Ala Arg Gln Leu Ile Glu Glu Lys Ile Gly 
        435                 440                 445             


Gly Pro Val Asn Pro Leu Gly Pro Pro Val Pro His Gly Pro His Gly 
    450                 455                 460                 


Val Pro Gly Pro His Gly Pro Pro Gly Pro Pro Gly Pro Gly Thr Pro 
465                 470                 475                 480 


Met Gly Pro Tyr Asn Pro Ala Pro Tyr Asn Pro Gly Pro Pro Gly Pro 
                485                 490                 495     


Ala Pro His Gly Pro Pro Ala Pro Tyr Ala Pro Gln Gly Trp Gly Asn 
            500                 505                 510         


Ala Tyr Pro His Trp Gln Gln Gln Ala Pro Pro Asp Pro Ala Lys Ala 
        515                 520                 525             


Gly Thr Asp Pro Asn Ser Ala Ala Trp Ala Ala Tyr Tyr Ala His Tyr 
    530                 535                 540                 


Tyr Gln Gln Gln Ala Gln Pro Pro Pro Ala Ala Pro Ala Gly Ala Pro 
545                 550                 555                 560 


Thr Thr Thr Gln Thr Asn Gly Gln Gly Asp Gln Gln Asn Pro Ala Pro 
                565                 570                 575     


Ala Gly Gln Val Asp Tyr Thr Lys Ala Trp Glu Glu Tyr Tyr Lys Lys 
            580                 585                 590         


Met Gly Gln Ala Val Pro Ala Pro Thr Gly Ala Pro Pro Gly Gly Gln 
        595                 600                 605             


Pro Asp Tyr Ser Ala Ala Trp Ala Glu Tyr Tyr Arg Gln Gln Ala Ala 
    610                 615                 620                 


Tyr Tyr Ala Gln Thr Ser Pro Gln Gly Met Pro Gln His Pro Pro Ala 
625                 630                 635                 640 


Pro Gln Gly Gln 
                


<210>  40
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  41
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Glu Ser Glu Pro Glu Arg Lys Arg Ala Arg Thr Asp Glu Val 
1               5                   10                  15      


Pro Ala Gly Gly Ser Arg Ser Glu Ala Glu Asp Glu Asp Asp Glu Asp 
            20                  25                  30          


Tyr Val Pro Tyr Val Pro Leu Arg Gln Arg Arg Gln Leu Leu Leu Gln 
        35                  40                  45              


Lys Leu Leu Gln Arg Arg Arg Lys Gly Ala Ala Glu Glu Glu Gln Gln 
    50                  55                  60                  


Asp Ser Gly Ser Glu Pro Arg Gly Asp Glu Asp Asp Ile Pro Leu Gly 
65                  70                  75                  80  


Pro Gln Ser Asn Val Ser Leu Leu Asp Gln His Gln His Leu Lys Glu 
                85                  90                  95      


Lys Ala Glu Ala Arg Lys Glu Ser Ala Lys Glu Lys Gln Leu Lys Glu 
            100                 105                 110         


Glu Glu Lys Ile Leu Glu Ser Val Ala Glu Gly Arg Ala Leu Met Ser 
        115                 120                 125             


Val Lys Glu Met Ala Lys Gly Ile Thr Tyr Asp Asp Pro Ile Lys Thr 
    130                 135                 140                 


Ser Trp Thr Pro Pro Arg Tyr Val Leu Ser Met Ser Glu Glu Arg His 
145                 150                 155                 160 


Glu Arg Val Arg Lys Lys Tyr His Ile Leu Val Glu Gly Asp Gly Ile 
                165                 170                 175     


Pro Pro Pro Ile Lys Ser Phe Lys Glu Met Lys Phe Pro Ala Ala Ile 
            180                 185                 190         


Leu Arg Gly Leu Lys Lys Lys Gly Ile His His Pro Thr Pro Ile Gln 
        195                 200                 205             


Ile Gln Gly Ile Pro Thr Ile Leu Ser Gly Arg Asp Met Ile Gly Ile 
    210                 215                 220                 


Ala Phe Thr Gly Ser Gly Lys Thr Leu Val Phe Thr Leu Pro Val Ile 
225                 230                 235                 240 


Met Phe Cys Leu Glu Gln Glu Lys Arg Leu Pro Phe Ser Lys Arg Glu 
                245                 250                 255     


Gly Pro Tyr Gly Leu Ile Ile Cys Pro Ser Arg Glu Leu Ala Arg Gln 
            260                 265                 270         


Thr His Gly Ile Leu Glu Tyr Tyr Cys Arg Leu Leu Gln Glu Asp Ser 
        275                 280                 285             


Ser Pro Leu Leu Arg Cys Ala Leu Cys Ile Gly Gly Met Ser Val Lys 
    290                 295                 300                 


Glu Gln Met Glu Thr Ile Arg His Gly Val His Met Met Val Ala Thr 
305                 310                 315                 320 


Pro Gly Arg Leu Met Asp Leu Leu Gln Lys Lys Met Val Ser Leu Asp 
                325                 330                 335     


Ile Cys Arg Tyr Leu Ala Leu Asp Glu Ala Asp Arg Met Ile Asp Met 
            340                 345                 350         


Gly Phe Glu Gly Asp Ile Arg Thr Ile Phe Ser Tyr Phe Lys Gly Gln 
        355                 360                 365             


Arg Gln Thr Leu Leu Phe Ser Ala Thr Met Pro Lys Lys Ile Gln Asn 
    370                 375                 380                 


Phe Ala Lys Ser Ala Leu Val Lys Pro Val Thr Ile Asn Val Gly Arg 
385                 390                 395                 400 


Ala Gly Ala Ala Ser Leu Asp Val Ile Gln Glu Val Glu Tyr Val Lys 
                405                 410                 415     


Glu Glu Ala Lys Met Val Tyr Leu Leu Glu Cys Leu Gln Lys Thr Pro 
            420                 425                 430         


Pro Pro Val Leu Ile Phe Ala Glu Lys Lys Ala Asp Val Asp Ala Ile 
        435                 440                 445             


His Glu Tyr Leu Leu Leu Lys Gly Val Glu Ala Val Ala Ile His Gly 
    450                 455                 460                 


Gly Lys Asp Gln Glu Glu Arg Thr Lys Ala Ile Glu Ala Phe Arg Glu 
465                 470                 475                 480 


Gly Lys Lys Asp Val Leu Val Ala Thr Asp Val Ala Ser Lys Gly Leu 
                485                 490                 495     


Asp Phe Pro Ala Ile Gln His Val Ile Asn Tyr Asp Met Pro Glu Glu 
            500                 505                 510         


Ile Glu Asn Tyr Val His Arg Ile Gly Arg Thr Gly Arg Ser Gly Asn 
        515                 520                 525             


Thr Gly Ile Ala Thr Thr Phe Ile Asn Lys Ala Cys Asp Glu Ser Val 
    530                 535                 540                 


Leu Met Asp Leu Lys Ala Leu Leu Leu Glu Ala Lys Gln Lys Val Pro 
545                 550                 555                 560 


Pro Val Leu Gln Val Leu His Cys Gly Asp Glu Ser Met Leu Asp Ile 
                565                 570                 575     


Gly Gly Glu Arg Gly Cys Ala Phe Cys Gly Gly Leu Gly His Arg Ile 
            580                 585                 590         


Thr Asp Cys Pro Lys Leu Glu Ala Met Gln Thr Lys Gln Val Ser Asn 
        595                 600                 605             


Ile Gly Arg Lys Asp Tyr Leu Ala His Ser Ser Met Asp Phe 
    610                 615                 620         


<210>  42
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  43
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Asp Ile Ile Ala Arg Leu Arg Glu Asp Gly Ile Gln Lys Arg 
1               5                   10                  15      


Val Ile Gln Glu Gly Arg Gly Glu Leu Pro Asp Phe Gln Asp Gly Thr 
            20                  25                  30          


Lys Ala Thr Phe His Tyr Arg Thr Leu His Ser Asp Asp Glu Gly Thr 
        35                  40                  45              


Val Leu Asp Asp Ser Arg Ala Arg Gly Lys Pro Met Glu Leu Ile Ile 
    50                  55                  60                  


Gly Lys Lys Phe Lys Leu Pro Val Trp Glu Thr Ile Val Cys Thr Met 
65                  70                  75                  80  


Arg Glu Gly Glu Ile Ala Gln Phe Leu Cys Asp Ile Lys His Val Val 
                85                  90                  95      


Leu Tyr Pro Leu Val Ala Lys Ser Leu Arg Asn Ile Ala Val Gly Lys 
            100                 105                 110         


Asp Pro Leu Glu Gly Gln Arg His Cys Cys Gly Val Ala Gln Met Arg 
        115                 120                 125             


Glu His Ser Ser Leu Gly His Ala Asp Leu Asp Ala Leu Gln Gln Asn 
    130                 135                 140                 


Pro Gln Pro Leu Ile Phe His Met Glu Met Leu Lys Val Glu Ser Pro 
145                 150                 155                 160 


Gly Thr Tyr Gln Gln Asp Pro Trp Ala Met Thr Asp Glu Glu Lys Ala 
                165                 170                 175     


Lys Ala Val Pro Leu Ile His Gln Glu Gly Asn Arg Leu Tyr Arg Glu 
            180                 185                 190         


Gly His Val Lys Glu Ala Ala Ala Lys Tyr Tyr Asp Ala Ile Ala Cys 
        195                 200                 205             


Leu Lys Asn Leu Gln Met Lys Glu Gln Pro Gly Ser Pro Glu Trp Ile 
    210                 215                 220                 


Gln Leu Asp Gln Gln Ile Thr Pro Leu Leu Leu Asn Tyr Cys Gln Cys 
225                 230                 235                 240 


Lys Leu Val Val Glu Glu Tyr Tyr Glu Val Leu Asp His Cys Ser Ser 
                245                 250                 255     


Ile Leu Asn Lys Tyr Asp Asp Asn Val Lys Ala Tyr Phe Lys Arg Gly 
            260                 265                 270         


Lys Ala His Ala Ala Val Trp Asn Ala Gln Glu Ala Gln Ala Asp Phe 
        275                 280                 285             


Ala Lys Val Leu Glu Leu Asp Pro Ala Leu Ala Pro Val Val Ser Arg 
    290                 295                 300                 


Glu Leu Gln Ala Leu Glu Ala Arg Ile Arg Gln Lys Asp Glu Glu Asp 
305                 310                 315                 320 


Lys Ala Arg Phe Arg Gly Ile Phe Ser His 
                325                 330 


<210>  44
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Ser Ser Asp Leu Glu Gln Leu Cys Ser His Val Asn Glu Lys 
1               5                   10                  15      


Ile Gly Asn Ile Lys Lys Thr Leu Ser Leu Arg Asn Cys Gly Gln Glu 
            20                  25                  30          


Pro Thr Leu Lys Thr Val Leu Asn Lys Ile Gly Asp Glu Ile Ile Val 
        35                  40                  45              


Ile Asn Glu Leu Leu Asn Lys Leu Glu Leu Glu Ile Gln Tyr Gln Glu 
    50                  55                  60                  


Gln Thr Asn Asn Ser Leu Lys Glu Leu Cys Glu Ser Leu Glu Glu Asp 
65                  70                  75                  80  


Tyr Lys Asp Ile Glu His Leu Lys Glu Asn Val Pro Ser His Leu Pro 
                85                  90                  95      


Gln Val Thr Val Thr Gln Ser Cys Val Lys Gly Ser Asp Leu Asp Pro 
            100                 105                 110         


Glu Glu Pro Ile Lys Val Glu Glu Pro Glu Pro Val Lys Lys Pro Pro 
        115                 120                 125             


Lys Glu Gln Arg Ser Ile Lys Glu Met Pro Phe Ile Thr Cys Asp Glu 
    130                 135                 140                 


Phe Asn Gly Val Pro Ser Tyr Met Lys Ser Arg Leu Thr Tyr Asn Gln 
145                 150                 155                 160 


Ile Asn Asp Val Ile Lys Glu Ile Asn Lys Ala Val Ile Ser Lys Tyr 
                165                 170                 175     


Lys Ile Leu His Gln Pro Lys Lys Ser Met Asn Ser Val Thr Arg Asn 
            180                 185                 190         


Leu Tyr His Arg Phe Ile Asp Glu Glu Thr Lys Asp Thr Lys Gly Arg 
        195                 200                 205             


Tyr Phe Ile Val Glu Ala Asp Ile Lys Glu Phe Thr Thr Leu Lys Ala 
    210                 215                 220                 


Asp Lys Lys Phe His Val Leu Leu Asn Ile Leu Arg His Cys Arg Arg 
225                 230                 235                 240 


Leu Ser Glu Val Arg Gly Gly Gly Leu Thr Arg Tyr Val Ile Thr 
                245                 250                 255 


