                         SEQUENCE LISTING

<110>  Yale University
       Gunel, Murat
       Lifton, Richard
       State, Matthew
       Bilguvar, Kaya
 
<120>  Assays for detecting WDR62 mutations

<130>  047162-5077-00-WO.600920

<150>  US 61/398,815
<151>  2010-07-01

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  4746
<212>  DNA
<213>  Homo sapiens

<400>  1
tttcccgcgg ctgttcgctg ttccagtggg tcgtggcggt ggcggcagcg gcggttaggg       60

gatgtaacgg tcgcccgcct ccggcgtgac gatggcggcc gtagggtccg gaggctatgc      120

gcggaacgat gcaggggaga agctgccctc tgtcatggcg ggagttccgg cgcggagggg      180

ccagtcctcc ccgccccccg ccccaccaat ctgcctacgg cggcggacgc gactctcgac      240

ggcctccgag gagacggtgc agaaccgggt gtcactcgag aaggtgcttg gcatcacagc      300

ccagaacagc agtggcctaa cctgtgaccc cggcacaggc catgtggcct acctggcagg      360

ctgtgtggtg gtgattttgg accccaagga gaacaagcag cagcacatct ttaacaccgc      420

caggaagtct ctcagtgctc tggccttctc ccctgatggg aagtacatag tgacagggga      480

gaatgggcat aggcctgctg tgcgcatctg ggatgtggag gagaagaatc aggtggcgga      540

gatgctaggc cacaagtatg gtgtggcgtg tgtggccttc tcacccaata tgaagcacat      600

cgtgtccatg ggctaccaac atgacatggt gctcaacgtc tgggactgga agaaagacat      660

cgtagtggcc tccaacaagg tatcttgtag agtcattgcc ctctccttct cagaggacag      720

cagctatttt gtcactgttg ggaaccgcca tgtgaggttc tggttcttgg aagtctccac      780

tgagacaaag gtgacgagca cagtgcccct tgtagggcgc tcgggcatcc tgggcgagct      840

gcacaacaac atcttctgtg gtgtggcctg cggtcggggc cggatggcgg gcagtacctt      900

ctgtgtgtcc tactcgggcc tcctctgcca gttcaatgag aagagggtgc tggagaagtg      960

gatcaacctg aaggtctccc tgtcttcctg cctctgtgtc agccaggagc tcatcttctg     1020

tggctgcaca gatgggatag tccgcatctt ccaggcccat agcctgcact acctcgccaa     1080

cctgcccaag ccacactacc ttggggtaga cgtggcacag ggcctggagc ccagcttcct     1140

cttccacagg aaggcggaag cagtctaccc agatacagtg gcactgacct tcgaccccat     1200

ccaccagtgg ctgtcctgcg tgtataagga ccacagcatc tacatctggg atgtcaagga     1260

catcaacaga gtgggcaagg tgtggtcaga gctcttccac agctcctacg tttggaacgt     1320

ggaggtgtat cctgagtttg aagaccagag agcttgtttg ccatcaggat cctttctgac     1380

ttgttcttca gacaacacca ttcgcttctg gaacttggac agcagccctg attctcactg     1440

gcagaaaaac atcttcagca ataccctgct gaaggtcgtg tacgtggaga atgacatcca     1500

gcacctgcag gacatgtcac acttcccaga ccgggggagc gagaatggga cacccatgga     1560

cgtgaaagcc ggggtgcggg tcatgcaggt cagtcctgac ggccagcatt tggcttcagg     1620

cgaccgaagt ggaaatctga ggatccacga gctgcacttc atggacgagc tggtcaaggt     1680

ggaggcccat gatgctgagg tgctgtgcct ggagtactcc aagccagaga cggggctgac     1740

cttgctggcc tcagccagtc gggaccggct gatccatgtg ctgaacgtgg agaagaacta     1800

caacctggag cagacgctgg atgaccactc ctcctccatc accgccatca agttcgctgg     1860

caacagagac atccagatga tcagctgtgg ggctgacaag agcatctact ttcgcagtgc     1920

ccagcagggt tcggatggac tacactttgt ccgtacccac cacgtagcag agaaaaccac     1980

cttgtatgac atggacattg acatcaccca gaagtacgtg gccgtggcct gccaggaccg     2040

caatgtgaga gtctacaaca ctgtgaacgg gaagcagaag aagtgctaca agggctccca     2100

gggtgacgaa gggtccttgc tgaaggtcca tgtggacccc tcaggcacct tcctggccac     2160

cagctgctct gacaaaagca tctcagtgat tgacttttac tcgggcgagt gcattgccaa     2220

gatgtttggc cattcagaaa ttattaccag catgaagttc acctatgact gtcatcactt     2280

gatcacagta tctggagaca gctgcgtgtt catctggcac ctgggcccgg agatcaccaa     2340

ctgcatgaag cagcacttgc tggagattga ccaccggcag cagcagcagc acacaaatga     2400

caagaagcgg agtggccacc ccaggcagga tacgtatgtg tccacaccta gtgagattca     2460

ctccctgagc cctggagagc aaacagagga tgatctggag gaagagtgtg agccagaaga     2520

gatgctgaag acaccatcca aagatagctt ggatccagat cctcgttgcc tgctaaccaa     2580

cggcaagctg ccactgtggg caaagcggct gctaggggac gatgatgtgg cagatggctt     2640

ggccttccac gccaagcgca gctaccagcc ccacggccgc tgggcagagc gggccggcca     2700

agagcccctc aagaccatcc tggatgccca ggacctggat tgctacttta cccccatgaa     2760

gcccgagagt ctggagaact ccattctgga ttcactggag ccacagagcc tggccagcct     2820

gctgagtgag tcagagagtc cccaggaagc tggccgcggg cacccctcct tcctgcccca     2880

gcagaaggaa tcatctgagg ccagtgagct catcctctac tctctggagg cagaagtgac     2940

agtcacaggg acagacagcc agtattgcag gaaggaggtg gaggccgggc ctggagacca     3000

gcagggcgac tcctacctca gggtgtcctc cgacagccca aaggaccaga gcccgcctga     3060

ggactcgggg gagtcagagg ccgacctgga gtgcagcttc gcagccatcc actccccagc     3120

tccgcctcct gaccctgccc ctcggtttgc cacgtcgctg ccccatttcc caggatgcgc     3180

aggtcccaca gaagatgagc tgtccctgcc cgagggaccc agcgtcccca gcagctccct     3240

accccagact ccggagcagg agaagttcct ccgccaccac tttgagacac tgactgagtc     3300

cccctgcaga gagctcttcc ccgcagctct gggagacgtg gaggcctctg aagctgaaga     3360

ccacttcttc aacccacgcc tgagtatctc cacgcagttc ctctcaagcc tccagaaggc     3420

atccaggttc acccatacct tccctccccg ggcaacccag tgccttgtga agtctccaga     3480

ggtcaagctc atggaccgag gcggaagcca gcccagagca ggtactggct acgcctcccc     3540

agacaggacc cacgtcctcg ctgcagggaa ggctgaagag accctggagg cctggcgccc     3600

accacctccc tgccttacga gcctggcgtc ctgtgtccct gcttcctccg tgctgcccac     3660

agacaggaat ctcccaacgc ccacatctgc acccacccca ggcctggctc agggtgtcca     3720

tgccccctcc acctgttcct acatggaggc cactgccagc tcccgtgcca ggatatcacg     3780

cagcatctcc ctcggtgaca gtgagggccc tatcgtggcc acactggccc agcccctccg     3840

taggccatcg tccgttgggg agctggcctc cttgggccag gagcttcagg ccatcaccac     3900

cgcgacaaca cccagtttgg acagtgaggg ccaagagcct gccctgcgtt cctggggcaa     3960

ccacgaggcc cgggccaacc tgagactgac cctgtcaagt gcctgtgatg ggctcctgca     4020

gccccccgtg gatacccagc ctggcgtcac cgtccctgca gtgagcttcc cagcccctag     4080

ccctgtggaa gagagcgccc tgaggctcca cggctctgcc tttcgcccaa gtctcccagc     4140

tcctgagtcc cctggccttc ctgcccaccc cagtaacccc cagcttccag aggcccggcc     4200

tggcatccct ggcggcactg cctccctcct ggagcccacc tccggtgcac ttggtctgtt     4260

acagggcagc cctgcccgct ggagtgagcc ctgggtgccg gttgaagccc tgcccccatc     4320

tccccttgag ctgagcaggg tggggaacat cttgcacagg ctgcagacca ccttccaaga     4380

agccctcgac ctttaccgtg tgttggtctc cagtggccag gtggacaccg ggcagcagca     4440

ggcacggact gagctggtct ccaccttcct gtggatccac agccagctgg aggctgaatg     4500

cctggtgggg actagtgtgg ccccagccca ggctctgccc agcccaggac ccccgtcccc     4560

accgacgctg taccccctgg ccagcccaga cctgcaggcc ctgctggaac actactcgga     4620

gctgctggtg caggccgtgc ggaggaaggc acgggggcac tgagggcgca gcccctccac     4680

cgcagccctg ctgcttctga ggacttaggt attttaagcg aataaactga cagctttgag     4740

gaatga                                                                4746


<210>  2
<211>  1523
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Val Gly Ser Gly Gly Tyr Ala Arg Asn Asp Ala Gly Glu 
1               5                   10                  15      


Lys Leu Pro Ser Val Met Ala Gly Val Pro Ala Arg Arg Gly Gln Ser 
            20                  25                  30          


Ser Pro Pro Pro Ala Pro Pro Ile Cys Leu Arg Arg Arg Thr Arg Leu 
        35                  40                  45              


Ser Thr Ala Ser Glu Glu Thr Val Gln Asn Arg Val Ser Leu Glu Lys 
    50                  55                  60                  


Val Leu Gly Ile Thr Ala Gln Asn Ser Ser Gly Leu Thr Cys Asp Pro 
65                  70                  75                  80  


Gly Thr Gly His Val Ala Tyr Leu Ala Gly Cys Val Val Val Ile Leu 
                85                  90                  95      


Asp Pro Lys Glu Asn Lys Gln Gln His Ile Phe Asn Thr Ala Arg Lys 
            100                 105                 110         


Ser Leu Ser Ala Leu Ala Phe Ser Pro Asp Gly Lys Tyr Ile Val Thr 
        115                 120                 125             


Gly Glu Asn Gly His Arg Pro Ala Val Arg Ile Trp Asp Val Glu Glu 
    130                 135                 140                 


Lys Asn Gln Val Ala Glu Met Leu Gly His Lys Tyr Gly Val Ala Cys 
145                 150                 155                 160 


Val Ala Phe Ser Pro Asn Met Lys His Ile Val Ser Met Gly Tyr Gln 
                165                 170                 175     


His Asp Met Val Leu Asn Val Trp Asp Trp Lys Lys Asp Ile Val Val 
            180                 185                 190         


Ala Ser Asn Lys Val Ser Cys Arg Val Ile Ala Leu Ser Phe Ser Glu 
        195                 200                 205             


Asp Ser Ser Tyr Phe Val Thr Val Gly Asn Arg His Val Arg Phe Trp 
    210                 215                 220                 


Phe Leu Glu Val Ser Thr Glu Thr Lys Val Thr Ser Thr Val Pro Leu 
225                 230                 235                 240 


Val Gly Arg Ser Gly Ile Leu Gly Glu Leu His Asn Asn Ile Phe Cys 
                245                 250                 255     


Gly Val Ala Cys Gly Arg Gly Arg Met Ala Gly Ser Thr Phe Cys Val 
            260                 265                 270         


Ser Tyr Ser Gly Leu Leu Cys Gln Phe Asn Glu Lys Arg Val Leu Glu 
        275                 280                 285             


Lys Trp Ile Asn Leu Lys Val Ser Leu Ser Ser Cys Leu Cys Val Ser 
    290                 295                 300                 


Gln Glu Leu Ile Phe Cys Gly Cys Thr Asp Gly Ile Val Arg Ile Phe 
305                 310                 315                 320 


Gln Ala His Ser Leu His Tyr Leu Ala Asn Leu Pro Lys Pro His Tyr 
                325                 330                 335     


Leu Gly Val Asp Val Ala Gln Gly Leu Glu Pro Ser Phe Leu Phe His 
            340                 345                 350         


Arg Lys Ala Glu Ala Val Tyr Pro Asp Thr Val Ala Leu Thr Phe Asp 
        355                 360                 365             


Pro Ile His Gln Trp Leu Ser Cys Val Tyr Lys Asp His Ser Ile Tyr 
    370                 375                 380                 


Ile Trp Asp Val Lys Asp Ile Asn Arg Val Gly Lys Val Trp Ser Glu 
385                 390                 395                 400 


Leu Phe His Ser Ser Tyr Val Trp Asn Val Glu Val Tyr Pro Glu Phe 
                405                 410                 415     


Glu Asp Gln Arg Ala Cys Leu Pro Ser Gly Ser Phe Leu Thr Cys Ser 
            420                 425                 430         


Ser Asp Asn Thr Ile Arg Phe Trp Asn Leu Asp Ser Ser Pro Asp Ser 
        435                 440                 445             


His Trp Gln Lys Asn Ile Phe Ser Asn Thr Leu Leu Lys Val Val Tyr 
    450                 455                 460                 


Val Glu Asn Asp Ile Gln His Leu Gln Asp Met Ser His Phe Pro Asp 
465                 470                 475                 480 


Arg Gly Ser Glu Asn Gly Thr Pro Met Asp Val Lys Ala Gly Val Arg 
                485                 490                 495     


Val Met Gln Val Ser Pro Asp Gly Gln His Leu Ala Ser Gly Asp Arg 
            500                 505                 510         


Ser Gly Asn Leu Arg Ile His Glu Leu His Phe Met Asp Glu Leu Val 
        515                 520                 525             


Lys Val Glu Ala His Asp Ala Glu Val Leu Cys Leu Glu Tyr Ser Lys 
    530                 535                 540                 


Pro Glu Thr Gly Leu Thr Leu Leu Ala Ser Ala Ser Arg Asp Arg Leu 
545                 550                 555                 560 


Ile His Val Leu Asn Val Glu Lys Asn Tyr Asn Leu Glu Gln Thr Leu 
                565                 570                 575     


Asp Asp His Ser Ser Ser Ile Thr Ala Ile Lys Phe Ala Gly Asn Arg 
            580                 585                 590         


Asp Ile Gln Met Ile Ser Cys Gly Ala Asp Lys Ser Ile Tyr Phe Arg 
        595                 600                 605             


Ser Ala Gln Gln Gly Ser Asp Gly Leu His Phe Val Arg Thr His His 
    610                 615                 620                 


Val Ala Glu Lys Thr Thr Leu Tyr Asp Met Asp Ile Asp Ile Thr Gln 
625                 630                 635                 640 


Lys Tyr Val Ala Val Ala Cys Gln Asp Arg Asn Val Arg Val Tyr Asn 
                645                 650                 655     


Thr Val Asn Gly Lys Gln Lys Lys Cys Tyr Lys Gly Ser Gln Gly Asp 
            660                 665                 670         


Glu Gly Ser Leu Leu Lys Val His Val Asp Pro Ser Gly Thr Phe Leu 
        675                 680                 685             


Ala Thr Ser Cys Ser Asp Lys Ser Ile Ser Val Ile Asp Phe Tyr Ser 
    690                 695                 700                 


Gly Glu Cys Ile Ala Lys Met Phe Gly His Ser Glu Ile Ile Thr Ser 
705                 710                 715                 720 


Met Lys Phe Thr Tyr Asp Cys His His Leu Ile Thr Val Ser Gly Asp 
                725                 730                 735     


Ser Cys Val Phe Ile Trp His Leu Gly Pro Glu Ile Thr Asn Cys Met 
            740                 745                 750         


Lys Gln His Leu Leu Glu Ile Asp His Arg Gln Gln Gln Gln His Thr 
        755                 760                 765             


Asn Asp Lys Lys Arg Ser Gly His Pro Arg Gln Asp Thr Tyr Val Ser 
    770                 775                 780                 


Thr Pro Ser Glu Ile His Ser Leu Ser Pro Gly Glu Gln Thr Glu Asp 
785                 790                 795                 800 


Asp Leu Glu Glu Glu Cys Glu Pro Glu Glu Met Leu Lys Thr Pro Ser 
                805                 810                 815     


Lys Asp Ser Leu Asp Pro Asp Pro Arg Cys Leu Leu Thr Asn Gly Lys 
            820                 825                 830         


Leu Pro Leu Trp Ala Lys Arg Leu Leu Gly Asp Asp Asp Val Ala Asp 
        835                 840                 845             


Gly Leu Ala Phe His Ala Lys Arg Ser Tyr Gln Pro His Gly Arg Trp 
    850                 855                 860                 


Ala Glu Arg Ala Gly Gln Glu Pro Leu Lys Thr Ile Leu Asp Ala Gln 
865                 870                 875                 880 


Asp Leu Asp Cys Tyr Phe Thr Pro Met Lys Pro Glu Ser Leu Glu Asn 
                885                 890                 895     


Ser Ile Leu Asp Ser Leu Glu Pro Gln Ser Leu Ala Ser Leu Leu Ser 
            900                 905                 910         


Glu Ser Glu Ser Pro Gln Glu Ala Gly Arg Gly His Pro Ser Phe Leu 
        915                 920                 925             


Pro Gln Gln Lys Glu Ser Ser Glu Ala Ser Glu Leu Ile Leu Tyr Ser 
    930                 935                 940                 


Leu Glu Ala Glu Val Thr Val Thr Gly Thr Asp Ser Gln Tyr Cys Arg 
945                 950                 955                 960 


Lys Glu Val Glu Ala Gly Pro Gly Asp Gln Gln Gly Asp Ser Tyr Leu 
                965                 970                 975     


Arg Val Ser Ser Asp Ser Pro Lys Asp Gln Ser Pro Pro Glu Asp Ser 
            980                 985                 990         


Gly Glu Ser Glu Ala Asp Leu Glu  Cys Ser Phe Ala Ala  Ile His Ser 
        995                 1000                 1005             


Pro Ala  Pro Pro Pro Asp Pro  Ala Pro Arg Phe Ala  Thr Ser Leu 
    1010                 1015                 1020             


Pro His  Phe Pro Gly Cys Ala  Gly Pro Thr Glu Asp  Glu Leu Ser 
    1025                 1030                 1035             


Leu Pro  Glu Gly Pro Ser Val  Pro Ser Ser Ser Leu  Pro Gln Thr 
    1040                 1045                 1050             


Pro Glu  Gln Glu Lys Phe Leu  Arg His His Phe Glu  Thr Leu Thr 
    1055                 1060                 1065             


Glu Ser  Pro Cys Arg Glu Leu  Phe Pro Ala Ala Leu  Gly Asp Val 
    1070                 1075                 1080             


Glu Ala  Ser Glu Ala Glu Asp  His Phe Phe Asn Pro  Arg Leu Ser 
    1085                 1090                 1095             


Ile Ser  Thr Gln Phe Leu Ser  Ser Leu Gln Lys Ala  Ser Arg Phe 
    1100                 1105                 1110             


Thr His  Thr Phe Pro Pro Arg  Ala Thr Gln Cys Leu  Val Lys Ser 
    1115                 1120                 1125             


Pro Glu  Val Lys Leu Met Asp  Arg Gly Gly Ser Gln  Pro Arg Ala 
    1130                 1135                 1140             


Gly Thr  Gly Tyr Ala Ser Pro  Asp Arg Thr His Val  Leu Ala Ala 
    1145                 1150                 1155             


Gly Lys  Ala Glu Glu Thr Leu  Glu Ala Trp Arg Pro  Pro Pro Pro 
    1160                 1165                 1170             


Cys Leu  Thr Ser Leu Ala Ser  Cys Val Pro Ala Ser  Ser Val Leu 
    1175                 1180                 1185             


Pro Thr  Asp Arg Asn Leu Pro  Thr Pro Thr Ser Ala  Pro Thr Pro 
    1190                 1195                 1200             


Gly Leu  Ala Gln Gly Val His  Ala Pro Ser Thr Cys  Ser Tyr Met 
    1205                 1210                 1215             


Glu Ala  Thr Ala Ser Ser Arg  Ala Arg Ile Ser Arg  Ser Ile Ser 
    1220                 1225                 1230             


Leu Gly  Asp Ser Glu Gly Pro  Ile Val Ala Thr Leu  Ala Gln Pro 
    1235                 1240                 1245             


Leu Arg  Arg Pro Ser Ser Val  Gly Glu Leu Ala Ser  Leu Gly Gln 
    1250                 1255                 1260             


Glu Leu  Gln Ala Ile Thr Thr  Ala Thr Thr Pro Ser  Leu Asp Ser 
    1265                 1270                 1275             


Glu Gly  Gln Glu Pro Ala Leu  Arg Ser Trp Gly Asn  His Glu Ala 
    1280                 1285                 1290             


Arg Ala  Asn Leu Arg Leu Thr  Leu Ser Ser Ala Cys  Asp Gly Leu 
    1295                 1300                 1305             


Leu Gln  Pro Pro Val Asp Thr  Gln Pro Gly Val Thr  Val Pro Ala 
    1310                 1315                 1320             


Val Ser  Phe Pro Ala Pro Ser  Pro Val Glu Glu Ser  Ala Leu Arg 
    1325                 1330                 1335             


Leu His  Gly Ser Ala Phe Arg  Pro Ser Leu Pro Ala  Pro Glu Ser 
    1340                 1345                 1350             


Pro Gly  Leu Pro Ala His Pro  Ser Asn Pro Gln Leu  Pro Glu Ala 
    1355                 1360                 1365             


Arg Pro  Gly Ile Pro Gly Gly  Thr Ala Ser Leu Leu  Glu Pro Thr 
    1370                 1375                 1380             


Ser Gly  Ala Leu Gly Leu Leu  Gln Gly Ser Pro Ala  Arg Trp Ser 
    1385                 1390                 1395             


Glu Pro  Trp Val Pro Val Glu  Ala Leu Pro Pro Ser  Pro Leu Glu 
    1400                 1405                 1410             


Leu Ser  Arg Val Gly Asn Ile  Leu His Arg Leu Gln  Thr Thr Phe 
    1415                 1420                 1425             


Gln Glu  Ala Leu Asp Leu Tyr  Arg Val Leu Val Ser  Ser Gly Gln 
    1430                 1435                 1440             


Val Asp  Thr Gly Gln Gln Gln  Ala Arg Thr Glu Leu  Val Ser Thr 
    1445                 1450                 1455             


Phe Leu  Trp Ile His Ser Gln  Leu Glu Ala Glu Cys  Leu Val Gly 
    1460                 1465                 1470             


Thr Ser  Val Ala Pro Ala Gln  Ala Leu Pro Ser Pro  Gly Pro Pro 
    1475                 1480                 1485             


Ser Pro  Pro Thr Leu Tyr Pro  Leu Ala Ser Pro Asp  Leu Gln Ala 
    1490                 1495                 1500             


Leu Leu  Glu His Tyr Ser Glu  Leu Leu Val Gln Ala  Val Arg Arg 
    1505                 1510                 1515             


Lys Ala  Arg Gly His 
    1520             


<210>  3
<211>  4744
<212>  DNA
<213>  Mus musculus

<400>  3
ggctttcccg cggccattcg ctattcgagt gggtgctggc tacaggcggc tgttaagaag       60

cgtaacggac actggtctcc gacagcatga tggctgcctt agcggccgga ggttatacgc      120

ggagtgacac gatagaaaag ctgtcctctg tcatggcggg agttccggcg cggagaaacc      180

agtcctcccc gcctcctgcc ccaccgctct gcctccggcg gcggacgcga ctcgcggcgg      240

ctcccgagga cactgtgcag aaccgggtga cacttgagaa ggtgcttggc atcacagccc      300

agaacagcag cgggctaacc tgtgaccctg gcacaggcca tgtggcctac ttagcagggt      360

gcgtggtggt ggtcttgaac cccaaggaga acaagcagca gcatatattt aacacaacca      420

ggaagtccct gagtgctctg gccttctccc cagatgggaa gtacatagtg acaggagaga      480

atggacaccg gccagctgtg cgcatctggg atgtggagga gaagactcaa gtggcagaga      540

tgctgggcca caagtatggt gtggcctgtg tggctttctc acccaatatg aagcacatcg      600

tgtccatggg ctaccaacat gacatggtcc tcaatgtttg ggattggaag aaagacattg      660

tggtggcttc caacaaggtg tcatgtagag tcatcgctct ctccttctct gaggacagca      720

gctattttgt caccgttggg aatcggcatg tgaggttttg gttcttagaa gcctctactg      780

aggccaaggt aaccagcaca gtgcccctgg taggacgctc aggcatcctg ggtgagctgc      840

acaacaatat cttttgtggc gtggcctgcg gccggggccg gatggcaggc aataccttct      900

gtgtgtccta ctctggcctc ctctgccagt tcaatgagaa aagggtgctg gacaagtgga      960

tcaacctgaa ggtctccttg tcttcctgcc tgtgtgtcag tgacgagttg atcttctgtg     1020

gatgcacaga cgggatagtc cgcatcttcc aggcccacag cctactctac ctcaccaacc     1080

tgcccaaacc acactacctg ggagtggacg tggcccacgg actggactcc agcttcctct     1140

tccacagaaa agcagaagca gtctacccag atacagtggc cctgaccttt gaccccgtcc     1200

accagtggct gtcctgtgtt tacaaagacc acagcatcta catctgggat gtcaaggaca     1260

ttgatgaagt cagcaagata tggtcagagc tcttccacag ctcctttgtc tggaatgtag     1320

aggtgtaccc tgaatttgaa gaccagagag cttgcctgcc gtccgggact tttctgactt     1380

gttcctcaga caataccatc cgcttctgga atttggatag cgcctctgac actcgatggc     1440

aaaagaacat cttcagcgat tctctgctga aggtggtcta tgtagagaat gacatccagc     1500

acctgcagga cctgtctcac ttcccagacc ggggcagtga gaacggcact cccatggata     1560

tgaaagctgg ggttcgagtc atgcaggtca gtcctgacgg ccagcacttg gcttcaggcg     1620

accgcagtgg aaatctgagg atccacgagc tgcacttcat ggatgagctg atcaaggtgg     1680

aggcccacga tgctgaggtg ctgtgcctgg agtactccaa gcctgagaca ggagtgactt     1740

tgctggcttc agccagtcgg gacagactca tccatgtgtt aaacgtggag aagaactaca     1800

acctggagca gaccctggac gaccactcct cctccatcac agccattaag tttgctggca     1860

ccagagatgt ccagatgatc agttgtggag ctgacaagag catctacttt cgcagtgccc     1920

agcaggcctc ggatggactg cactttgtcc gtacccacca cgtagcagag aagaccacct     1980

tgtatgacat ggatatcgac atcacacaga agtatgtggc agtggcctgc caggaccgca     2040

acgtaagggt ctacaacacc gtgagtggga aacagaagaa gtgctacaag ggttcccagg     2100

gcgacgaagg gtccctgctg aaggtccacg tggacccctc aggcaccttc ctggccacaa     2160

gctgctctga caaaagcatc tccttgattg acttttactc gggcgagtgt gttgccaaga     2220

tgtttggcca ttcggaaatt gtcactggca tgaagttcac ctacgactgc cgccacttga     2280

tcacagtatc tggagacagc tgtgtgttca tctggcacct gggcccggag atcaccacct     2340

gcatgaagca gcacttgctg gagatcaacc accaggagca gcagcagcag cccaaggacc     2400

agaagtggag tggccctccc agccaggaga catatgcatc cacaccaagt gagattcgtt     2460

ccctgagccc tggagagcag acagaggatg agatggagga ggaatgtgag ccagaagagt     2520

tgctgaaaac accatccaaa gacagcttgg acccagatcc tcgatgcctg ctgacaaatg     2580

gcaagctgcc actctgggca aagcggctgc taggggatga tgatgtggca gacagctcag     2640

ctttccacgc caagcgcagc taccagccac atggccgttg ggcagagcgg gctgagcagg     2700

aacccctcaa gaccatcctg gatgcctgga gcctggattc ctactttaca cccatgaagc     2760

ctgaaaatct ccaagactct gttctggact cagtagagcc acagaacctg gcaggcctgc     2820

taagtgagtg ttcactcggt aatggacaca cgtctccggg agaaggcttg gtgagctacc     2880

tacttcaccc agagttaggg agtcccaaag aggacaaccg aggccacccc tcctacctgc     2940

ctctacagag ggaagccacc gaggcaagcg aactcatcct ctgctcccca gaggcggaag     3000

tgtcacttac agggatgcac agggagtatt atgaggagga gacagaggca ggacctgaag     3060

accagcaagg cgacacctat ctcagggtct cttccgtcag ttcaaaggat cagagccccc     3120

ctgaggactc aggggagtca gaggctgaac tggagtgcag ctttgccgcc gcccacagct     3180

cagctcctca aacggaccct ggccctcacc tcaccatgac agcaggtaag ccagagtacc     3240

caagtacaga agagctttcc cagcctgagc tgccaggctt gggcaatggc tccttacccc     3300

agacacctga gcaggagaag ttcctccgcc accattttga gacacttact gatgccccta     3360

ctgaagagct ctttcatgga tccctgggag acataaagat ctcagagact gaggactatt     3420

tcttcaatcc ccggctgagc atatccaccc agttcctctc ccgcctccag aagacctcca     3480

ggtgccctcc ccgactgccc ctgcacctta tgaagtctcc agaggctcag cctgtgggcc     3540

aagggggcaa ccagcccaaa gcagggcccc tgagagcagg tactggctac atgtcctcag     3600

atgggaccaa cgtcctctct gggcagaagg ctgaagaaac tcaagaggcc ttgagtctac     3660

tggacaggaa gcctccaaca cccacatctg tactgaccac aggccgggag caaagtatct     3720

ccgccccatc ttcgtgttct tacctggagt ccacaacgag ctcacatgcc aagacgacac     3780

gcagcatctc tcttggggac agtgagggcc ctgtgacagc tgagctaccc cagtcacttc     3840

acaagccctt atcccctggc caggaactcc aagccatccc cactacagtg gcactgacct     3900

ccagcatcaa agaccacgag cctgcaccgc tttcctgggg caaccatgag gcccgagcca     3960

gcctgaaact gaccttatcc agtgtctgtg agcagctgct ctctccacct ccacaggagc     4020

cacccatcac ccatgtgtgg tctcaggaac ctgtggatgt cccacctagt atggcagtca     4080

cagtagccag cttctgtgca cccagccctg tagacatgag caccctggga ctccacagtt     4140

ctatgtttct cccaaagacc tcagcctctg ggcccctaac ccctcctgcc cacctccaac     4200

ttctagagac caggtctagg gtgcctggca gcactgctgc tctcctggag cccacccccg     4260

atgcatcagg tgtgatcgca gacagccctg gacactggga cacagaagtc cctaccccag     4320

aactcctagg cagtgtggaa tcagtcttgc acaggctgca gactgccttc caagaagctc     4380

ttgaccttta ccgcatgctg gtctccagca gccagctggg tcctgagcag cagcaggcac     4440

agaccgagct ggcctccacc ttccactgga tcctcaacca gctagaagcc agcaactgta     4500

tggctgcagc taacttggcc ccaccccaga cactgcctag cccagaccct ctgtccctac     4560

ctacactttg tcccctggcc agcccaaacc tgcaggccct gctggaacac tactcagagt     4620

tgctggtgca agcagtgagg aggaaggcaa ggggtgactg agaacctgaa gcccctctac     4680

caaagccccg ctgccctgga gaaatagatt tgtaaaccaa taaactgaca gttgtttcct     4740

ggaa                                                                  4744


<210>  4
<211>  1524
<212>  PRT
<213>  Mus musculus

<400>  4

Met Met Ala Ala Leu Ala Ala Gly Gly Tyr Thr Arg Ser Asp Thr Ile 
1               5                   10                  15      


Glu Lys Leu Ser Ser Val Met Ala Gly Val Pro Ala Arg Arg Asn Gln 
            20                  25                  30          


Ser Ser Pro Pro Pro Ala Pro Pro Leu Cys Leu Arg Arg Arg Thr Arg 
        35                  40                  45              


Leu Ala Ala Ala Pro Glu Asp Thr Val Gln Asn Arg Val Thr Leu Glu 
    50                  55                  60                  


Lys Val Leu Gly Ile Thr Ala Gln Asn Ser Ser Gly Leu Thr Cys Asp 
65                  70                  75                  80  


Pro Gly Thr Gly His Val Ala Tyr Leu Ala Gly Cys Val Val Val Val 
                85                  90                  95      


Leu Asn Pro Lys Glu Asn Lys Gln Gln His Ile Phe Asn Thr Thr Arg 
            100                 105                 110         


Lys Ser Leu Ser Ala Leu Ala Phe Ser Pro Asp Gly Lys Tyr Ile Val 
        115                 120                 125             


Thr Gly Glu Asn Gly His Arg Pro Ala Val Arg Ile Trp Asp Val Glu 
    130                 135                 140                 


Glu Lys Thr Gln Val Ala Glu Met Leu Gly His Lys Tyr Gly Val Ala 
145                 150                 155                 160 


Cys Val Ala Phe Ser Pro Asn Met Lys His Ile Val Ser Met Gly Tyr 
                165                 170                 175     


Gln His Asp Met Val Leu Asn Val Trp Asp Trp Lys Lys Asp Ile Val 
            180                 185                 190         


Val Ala Ser Asn Lys Val Ser Cys Arg Val Ile Ala Leu Ser Phe Ser 
        195                 200                 205             


Glu Asp Ser Ser Tyr Phe Val Thr Val Gly Asn Arg His Val Arg Phe 
    210                 215                 220                 


Trp Phe Leu Glu Ala Ser Thr Glu Ala Lys Val Thr Ser Thr Val Pro 
225                 230                 235                 240 


Leu Val Gly Arg Ser Gly Ile Leu Gly Glu Leu His Asn Asn Ile Phe 
                245                 250                 255     


Cys Gly Val Ala Cys Gly Arg Gly Arg Met Ala Gly Asn Thr Phe Cys 
            260                 265                 270         


Val Ser Tyr Ser Gly Leu Leu Cys Gln Phe Asn Glu Lys Arg Val Leu 
        275                 280                 285             


Asp Lys Trp Ile Asn Leu Lys Val Ser Leu Ser Ser Cys Leu Cys Val 
    290                 295                 300                 


Ser Asp Glu Leu Ile Phe Cys Gly Cys Thr Asp Gly Ile Val Arg Ile 
305                 310                 315                 320 


Phe Gln Ala His Ser Leu Leu Tyr Leu Thr Asn Leu Pro Lys Pro His 
                325                 330                 335     


Tyr Leu Gly Val Asp Val Ala His Gly Leu Asp Ser Ser Phe Leu Phe 
            340                 345                 350         


His Arg Lys Ala Glu Ala Val Tyr Pro Asp Thr Val Ala Leu Thr Phe 
        355                 360                 365             


Asp Pro Val His Gln Trp Leu Ser Cys Val Tyr Lys Asp His Ser Ile 
    370                 375                 380                 


Tyr Ile Trp Asp Val Lys Asp Ile Asp Glu Val Ser Lys Ile Trp Ser 
385                 390                 395                 400 


Glu Leu Phe His Ser Ser Phe Val Trp Asn Val Glu Val Tyr Pro Glu 
                405                 410                 415     


Phe Glu Asp Gln Arg Ala Cys Leu Pro Ser Gly Thr Phe Leu Thr Cys 
            420                 425                 430         


Ser Ser Asp Asn Thr Ile Arg Phe Trp Asn Leu Asp Ser Ala Ser Asp 
        435                 440                 445             


Thr Arg Trp Gln Lys Asn Ile Phe Ser Asp Ser Leu Leu Lys Val Val 
    450                 455                 460                 


Tyr Val Glu Asn Asp Ile Gln His Leu Gln Asp Leu Ser His Phe Pro 
465                 470                 475                 480 


Asp Arg Gly Ser Glu Asn Gly Thr Pro Met Asp Met Lys Ala Gly Val 
                485                 490                 495     


Arg Val Met Gln Val Ser Pro Asp Gly Gln His Leu Ala Ser Gly Asp 
            500                 505                 510         


Arg Ser Gly Asn Leu Arg Ile His Glu Leu His Phe Met Asp Glu Leu 
        515                 520                 525             


Ile Lys Val Glu Ala His Asp Ala Glu Val Leu Cys Leu Glu Tyr Ser 
    530                 535                 540                 


Lys Pro Glu Thr Gly Val Thr Leu Leu Ala Ser Ala Ser Arg Asp Arg 
545                 550                 555                 560 


Leu Ile His Val Leu Asn Val Glu Lys Asn Tyr Asn Leu Glu Gln Thr 
                565                 570                 575     


Leu Asp Asp His Ser Ser Ser Ile Thr Ala Ile Lys Phe Ala Gly Thr 
            580                 585                 590         


Arg Asp Val Gln Met Ile Ser Cys Gly Ala Asp Lys Ser Ile Tyr Phe 
        595                 600                 605             


Arg Ser Ala Gln Gln Ala Ser Asp Gly Leu His Phe Val Arg Thr His 
    610                 615                 620                 


His Val Ala Glu Lys Thr Thr Leu Tyr Asp Met Asp Ile Asp Ile Thr 
625                 630                 635                 640 


Gln Lys Tyr Val Ala Val Ala Cys Gln Asp Arg Asn Val Arg Val Tyr 
                645                 650                 655     


Asn Thr Val Ser Gly Lys Gln Lys Lys Cys Tyr Lys Gly Ser Gln Gly 
            660                 665                 670         


Asp Glu Gly Ser Leu Leu Lys Val His Val Asp Pro Ser Gly Thr Phe 
        675                 680                 685             


Leu Ala Thr Ser Cys Ser Asp Lys Ser Ile Ser Leu Ile Asp Phe Tyr 
    690                 695                 700                 


Ser Gly Glu Cys Val Ala Lys Met Phe Gly His Ser Glu Ile Val Thr 
705                 710                 715                 720 


Gly Met Lys Phe Thr Tyr Asp Cys Arg His Leu Ile Thr Val Ser Gly 
                725                 730                 735     


Asp Ser Cys Val Phe Ile Trp His Leu Gly Pro Glu Ile Thr Thr Cys 
            740                 745                 750         


Met Lys Gln His Leu Leu Glu Ile Asn His Gln Glu Gln Gln Gln Gln 
        755                 760                 765             


Pro Lys Asp Gln Lys Trp Ser Gly Pro Pro Ser Gln Glu Thr Tyr Ala 
    770                 775                 780                 


Ser Thr Pro Ser Glu Ile Arg Ser Leu Ser Pro Gly Glu Gln Thr Glu 
785                 790                 795                 800 


Asp Glu Met Glu Glu Glu Cys Glu Pro Glu Glu Leu Leu Lys Thr Pro 
                805                 810                 815     


Ser Lys Asp Ser Leu Asp Pro Asp Pro Arg Cys Leu Leu Thr Asn Gly 
            820                 825                 830         


Lys Leu Pro Leu Trp Ala Lys Arg Leu Leu Gly Asp Asp Asp Val Ala 
        835                 840                 845             


Asp Ser Ser Ala Phe His Ala Lys Arg Ser Tyr Gln Pro His Gly Arg 
    850                 855                 860                 


Trp Ala Glu Arg Ala Glu Gln Glu Pro Leu Lys Thr Ile Leu Asp Ala 
865                 870                 875                 880 


Trp Ser Leu Asp Ser Tyr Phe Thr Pro Met Lys Pro Glu Asn Leu Gln 
                885                 890                 895     


Asp Ser Val Leu Asp Ser Val Glu Pro Gln Asn Leu Ala Gly Leu Leu 
            900                 905                 910         


Ser Glu Cys Ser Leu Gly Asn Gly His Thr Ser Pro Gly Glu Gly Leu 
        915                 920                 925             


Val Ser Tyr Leu Leu His Pro Glu Leu Gly Ser Pro Lys Glu Asp Asn 
    930                 935                 940                 


Arg Gly His Pro Ser Tyr Leu Pro Leu Gln Arg Glu Ala Thr Glu Ala 
945                 950                 955                 960 


Ser Glu Leu Ile Leu Cys Ser Pro Glu Ala Glu Val Ser Leu Thr Gly 
                965                 970                 975     


Met His Arg Glu Tyr Tyr Glu Glu Glu Thr Glu Ala Gly Pro Glu Asp 
            980                 985                 990         


Gln Gln Gly Asp Thr Tyr Leu Arg  Val Ser Ser Val Ser  Ser Lys Asp 
        995                 1000                 1005             


Gln Ser  Pro Pro Glu Asp Ser  Gly Glu Ser Glu Ala  Glu Leu Glu 
    1010                 1015                 1020             


Cys Ser  Phe Ala Ala Ala His  Ser Ser Ala Pro Gln  Thr Asp Pro 
    1025                 1030                 1035             


Gly Pro  His Leu Thr Met Thr  Ala Gly Lys Pro Glu  Tyr Pro Ser 
    1040                 1045                 1050             


Thr Glu  Glu Leu Ser Gln Pro  Glu Leu Pro Gly Leu  Gly Asn Gly 
    1055                 1060                 1065             


Ser Leu  Pro Gln Thr Pro Glu  Gln Glu Lys Phe Leu  Arg His His 
    1070                 1075                 1080             


Phe Glu  Thr Leu Thr Asp Ala  Pro Thr Glu Glu Leu  Phe His Gly 
    1085                 1090                 1095             


Ser Leu  Gly Asp Ile Lys Ile  Ser Glu Thr Glu Asp  Tyr Phe Phe 
    1100                 1105                 1110             


Asn Pro  Arg Leu Ser Ile Ser  Thr Gln Phe Leu Ser  Arg Leu Gln 
    1115                 1120                 1125             


Lys Thr  Ser Arg Cys Pro Pro  Arg Leu Pro Leu His  Leu Met Lys 
    1130                 1135                 1140             


Ser Pro  Glu Ala Gln Pro Val  Gly Gln Gly Gly Asn  Gln Pro Lys 
    1145                 1150                 1155             


Ala Gly  Pro Leu Arg Ala Gly  Thr Gly Tyr Met Ser  Ser Asp Gly 
    1160                 1165                 1170             


Thr Asn  Val Leu Ser Gly Gln  Lys Ala Glu Glu Thr  Gln Glu Ala 
    1175                 1180                 1185             


Leu Ser  Leu Leu Asp Arg Lys  Pro Pro Thr Pro Thr  Ser Val Leu 
    1190                 1195                 1200             


Thr Thr  Gly Arg Glu Gln Ser  Ile Ser Ala Pro Ser  Ser Cys Ser 
    1205                 1210                 1215             


Tyr Leu  Glu Ser Thr Thr Ser  Ser His Ala Lys Thr  Thr Arg Ser 
    1220                 1225                 1230             


Ile Ser  Leu Gly Asp Ser Glu  Gly Pro Val Thr Ala  Glu Leu Pro 
    1235                 1240                 1245             


Gln Ser  Leu His Lys Pro Leu  Ser Pro Gly Gln Glu  Leu Gln Ala 
    1250                 1255                 1260             


Ile Pro  Thr Thr Val Ala Leu  Thr Ser Ser Ile Lys  Asp His Glu 
    1265                 1270                 1275             


Pro Ala  Pro Leu Ser Trp Gly  Asn His Glu Ala Arg  Ala Ser Leu 
    1280                 1285                 1290             


Lys Leu  Thr Leu Ser Ser Val  Cys Glu Gln Leu Leu  Ser Pro Pro 
    1295                 1300                 1305             


Pro Gln  Glu Pro Pro Ile Thr  His Val Trp Ser Gln  Glu Pro Val 
    1310                 1315                 1320             


Asp Val  Pro Pro Ser Met Ala  Val Thr Val Ala Ser  Phe Cys Ala 
    1325                 1330                 1335             


Pro Ser  Pro Val Asp Met Ser  Thr Leu Gly Leu His  Ser Ser Met 
    1340                 1345                 1350             


Phe Leu  Pro Lys Thr Ser Ala  Ser Gly Pro Leu Thr  Pro Pro Ala 
    1355                 1360                 1365             


His Leu  Gln Leu Leu Glu Thr  Arg Ser Arg Val Pro  Gly Ser Thr 
    1370                 1375                 1380             


Ala Ala  Leu Leu Glu Pro Thr  Pro Asp Ala Ser Gly  Val Ile Ala 
    1385                 1390                 1395             


Asp Ser  Pro Gly His Trp Asp  Thr Glu Val Pro Thr  Pro Glu Leu 
    1400                 1405                 1410             


Leu Gly  Ser Val Glu Ser Val  Leu His Arg Leu Gln  Thr Ala Phe 
    1415                 1420                 1425             


Gln Glu  Ala Leu Asp Leu Tyr  Arg Met Leu Val Ser  Ser Ser Gln 
    1430                 1435                 1440             


Leu Gly  Pro Glu Gln Gln Gln  Ala Gln Thr Glu Leu  Ala Ser Thr 
    1445                 1450                 1455             


Phe His  Trp Ile Leu Asn Gln  Leu Glu Ala Ser Asn  Cys Met Ala 
    1460                 1465                 1470             


Ala Ala  Asn Leu Ala Pro Pro  Gln Thr Leu Pro Ser  Pro Asp Pro 
    1475                 1480                 1485             


Leu Ser  Leu Pro Thr Leu Cys  Pro Leu Ala Ser Pro  Asn Leu Gln 
    1490                 1495                 1500             


Ala Leu  Leu Glu His Tyr Ser  Glu Leu Leu Val Gln  Ala Val Arg 
    1505                 1510                 1515             


Arg Lys  Ala Arg Gly Asp 
    1520                 


