						SEQUENCE LISTING

<110>  DUCHATEAU Philippe
       VALTON Julien
	 DABOUSSI Fayza
 
<120>  METHOD FOR IMPROVING CLEAVAGE OF DNA BY ENDONUCLEASE SENSITIVE TO METHYLATION

<130>  382184WO

<160>  68   

<170>  PatentIn version 3.5


<210>  1
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  1
Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 


<210>  2
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  XPC4_SCOH

<400>  2
Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser His Lys Phe Lys His Ala Leu Gln Leu Thr Phe Lys Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Asn Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Ala Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser His 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Ala Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  3
<211>  354
<212>  PRT
<213>  artificial sequence

<220>  
<223>  SCOH_ADC

<400>  3
Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Thr Phe Arg Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Asn Tyr Asp Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asp Gln Ser Tyr 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Gly Leu Thr Phe Gln Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        
<210>  4
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1221_Forward

<400>  4
ggggtcaaaa cgtcgtacga cgttttgagg gg                                   32

<210>  5
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  C1221_Reverse

<400>  5
cccctcaaaa cgtcgtacga cgttttgacc cc                                   32

<210>  6
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1221_1Me_Forward

<400>  6
ggggtcaaaa c(M)gtcgtacg acgttttgag ggg                                  32


<210>  7
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  C1221_1Me_Reverse

<400>  7
cccctcaaaa cgtcgtacga c(M)gttttgacc cc                                   32

<210>  8
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1221_2Me_Forward

<400>  8
ggggtcaaaa c(M)gtc(M)gtacga cgttttgagg gg                                   32

<210>  9
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  C1221_2Me_Reverse

<400>  9
cccctcaaaa cgtcgtac(M)ga c(M)gttttgacc cc                                   32

<210>  10
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1221_3Me_Forward

<400>  10
ggggtcaaaa c(M)gtc(M)gtac(M)ga cgttttgagg gg                                   32

<210>  11
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  C1221_3Me_Reverse

<400>  11
cccctcaaaa cgtc(M)gtac(M)ga c(M)gttttgacc cc                                   32

<210>  12
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1221_4Me_Forward

<400>  12
ggggtcaaaa c(M)gtc(M)gtac(M)ga c(M)gttttgagg gg                                   32

<210>  13
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  C1221_4Me_Reverse

<400>  13
cccctcaaaa c(M)gtc(M)gtac(M)ga c(M)gttttgacc cc                                   32

<210>  14
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_XPC4_Forward

<400>  14
tcgagatgtc acacagaggt acga                                            24

<210>  15
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  XPC4_Reverse

<400>  15
tcgtacctct gtgtgacatc tcga                                            24

<210>  16
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_XPC4_2Me_Forward

<400>  16
tc(M)gagatgtc acacagaggt ac(M)ga                                            24

<210>  17
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  XPC4_2Me_Reverse

<400>  17
tc(M)gtacctct gtgtgacatc tc(M)ga                                            24


<210>  18
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_ADCY9_Forward

<400>  18
cccagatgtc gtacagcagc ttgg                                            24

<210>  19
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  ADCY9_Reverse

<400>  19
ccaagctgct gtacgacatc tggg                                            24

<210>  20
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_ADCY9_1Me_Forward

<400>  20
cccagatgtc(M) gtacagcagc ttgg                                            24

<210>  21
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  ADCY9_1Me_Reverse

<400>  21
ccaagctgct gtac(M)gacatc tggg                                            24

<210>  22
<211>  167
<212>  PRT
<213>  Artificial

<220>
<223>  I-CreI  N75

<400>  22
Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Ser Leu Ala Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Trp Arg 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  23
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  C1221 target

<400>  23
caaaacgtcg tacgacgttt tg                                              22


<210>  24
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  XPC4 target

<400>  24
tcgagatgtc acacagaggt acga                                            24



<210>  25
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  F1 PCR primer

<400>  25
gttggtatag attagtggtt agaggtgttt tg                                   32


<210>  26
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  R1 PCR primer

<400>  26
cttaaaaccc ctaacaacca aaaccttacc                                      30


<210>  27
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  F2 PCR primer

<400>  27
gtgggtatgt gtagattgtg tgtayggtgt g                                    31


<210>  28
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  R2 PCR primer

<400>  28
ctccaaatct tctttcttct ccctatcc                                        28


<210>  29
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  F3 Deep sequencing primer

<400>  29
ccatctcatc cctgcgtgtc tccgactcag tgccaagagg caagaaaatg tgcagc         56



<210>  30
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  R3 biotinylated Deep sequencing primer

<400>  30
cctatcccct gtgtgccttg gcagtctcag gctgggcata tataaggtgc tca            53


<210>  31
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1234_Forward

<400>  31
tcaaaacgtc gtgagacagt ttgg                                            24


<210>  32
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  C1234_Reverse

<400>  32
ccaaactgtc tcacgacgtt ttga                                            24


<210>  33
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1234_Me -6a_Forward

<400>  33
tcaaaac(M)gtc gtgagacagt ttgg                                            24


<210>  34
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1234_Me -3a_Forward

<400>  34
tcaaaacgtc(M) gtgagacagt ttgg                                            24


<210>  35
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  5'Fluo_C1234_Me -6a/-3a_Forward

<400>  35
tcaaaac(M)gtc(M) gtgagacagt ttgg                                            24


<210>  36
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  C1234_Me -5b_Reverse

<400>  36
ccaaactgtc tcacgac(M)gtt ttga                                            24


<210>  37
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  C1234_Me -2b_Reverse

<400>  37
ccaaactgtc tcac(M)gacgtt ttga                                            24


<210>  38
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  C1234_Me -5b/-2b_Reverse

<400>  38
ccaaactgtc tcac(M)gac(M)gtt ttga                                            24


<210>  39
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Random_Forward

<400>  39
gagagagaga gagagagaga ga                                              22


<210>  40
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Random_Reverse

<400>  40
tctctctctc tctctctctc tc                                              22



<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  XPC4 F4 PCR primer

<400>  41
ttaaggcgcg ccggaccgcg gc                                              22


<210>  42
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  XPC4 R4 PCR primer

<400>  42
gatcatatcg ttgggttacg tccctg                                          26


<210>  43
<211>  31
<212>  DNA
<213>  Artificial

<220>  
<223>  ADCY9 F1 PCR primer

<220>
<221>  misc_feature 
<222>  (13); (24)   
<223>  y is t or c

<400>  43
gtaggtttag gayggtagtt	attygtagga g                                   31


<210>  44
<211>  29
<212>  DNA
<213>  Artificial

<220>  
<223>  ADCY9 R1 PCR primer

<220>
<221>  misc_feature 
<222>  (15)
<223>  r is g or a

<400>  44
cccttaacat tcacratccc tctataatc                                       29


<210>  45
<211>  31
<212>  DNA
<213>  Artificial

<220>  
<223>  ADCY9 F2 PCR primer

<220>
<221>  misc_feature 
<222>  (6); (22); (24)   
<223>  y is t or c

<400>  45
gagttygtta aggagatgat gygygtggtg g                                    31


<210>  46
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Adaptator A

<220>
<221>  misc_feature 
<222>  (26)..(30)   
<223>  n is a, c, g or t

<400>  46
ccatctcatc cctgcgtgtc tccgacnnnn                                      30


<210>  47
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Adaptator B

<400>  47
cctatcccct gtgtgccttg gcagtctcag                                      30


<210>  48
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  ADCY9 F3 PCR primer
<220>
<221>  misc_feature 
<222>  (31)..(34)   
<223>  n is a, c, g or t

<400>  48
ccatctcatc cctgcgtgtc tccgactcag nnnnacagca gcatcgagaa gatc           54


<210>  49
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  ADCY9 R3 PCR primer

<400>  49
cctatcccct gtgtgccttg gcagtctcag atgctgccat ccacctggac g              51


<210>  50
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  ADCY9 F4 PCR primer

<400>  50
ttaaggcgcg ccggaccgcg gc                                              22


<210>  51
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  ADCY9 R4 PCR primer

<400>  51
tacgagttta agaccagcct tggc                                            24


<210>  52
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  RAG target sequence

<400>  52
ttgttctcag gtacctcagc cagc                                            24


<210>  53
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  CAPNS1 target sequence

<400>  53
cagggccgcg gtgcagtgtc cgac                                            24


<210>  54
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  CAPNS1 F1 PCR primer

<400>  54
gggtgttttt atttagattt gaggggtg                                        28


<210>  55
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  CAPNS1 R1 PCR primer

<220>
<221>  misc_feature 
<222>  (10); (22)
<223>  r is g or a

<400>  55
ctaaaaatcr attccactac crctccc                                         27


<210>  56
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  CAPNS1 F2 PCR primer

<220>
<221>  misc_feature 
<222>  (8); (23)
<223>  y is t or c

<400>  56
gttagggygg gattaagatt ttygg                                           25


<210>  57
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  RAG F1 primer
<220>
<221>  misc_feature 
<222>  (31)..(34)
<223>  n is a, c, g or t

<400>  57
ccatctcatc cctgcgtgtc tccgactcag nnnnggcaaa gatgaatcaa agattctgtc	 60
ct   								         62														
	

<210>  58
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  RAG R1 primer

<400>  57
cctatcccct gtgtgccttg gcagtctcag gatctcaccc ggaacagctt aaatttc        57


<210>  59
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  CAPNS1 F3 PCR primer

<220>
<221>  misc_feature 
<222>  (41)..(44)
<223>  n is a, c, g or t

<400>  59
ccatctcatc cctgcgtgtc tccgactcag nnnncgagtc agggcgggat taag           54


<210>  60
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  CAPNS1 R3 PCR primer

<400>  60
cctatcccct gtgtgccttg gcagtctcag cgagacttca cggtttcgcc                50


<210>  61

<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  SCOH-RAG pCLS2222

<400>  61
Met Ala Asn Thr Lys Tyr Asn Glu Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Asn Pro Asn Gln 
            20                  25                  30          


Ser Ser Lys Phe Lys His Arg Leu Arg Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Arg Asp Ser Gly Ser Val Ser Gln Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Glu Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Gly Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Gly Gly Ser Asp Lys Tyr Asn Gln Ala Leu 
                165                 170                 175     


Ser Lys Tyr Asn Gln Ala Leu Ser Lys Tyr Asn Gln Ala Leu Ser Gly 
            180                 185                 190         


Gly Gly Gly Ser Asn Lys Lys Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln Ser Asn 
    210                 215                 220                 


Lys Phe Lys His Gln Leu Ser Leu Thr Phe Ala Val Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Arg Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Tyr Asp Ser Gly Ser Val Ser Asp Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        

<210>  62

<211>  167
<212>  PRT
<213>  artificial sequence

<220>
<223>  pCLS4306_CAPNS1 I-CreI variant

<400>  62
Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Ser Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Arg Gln 
            20                  25                  30          


Ser Tyr Lys Phe Lys His Gln Leu Arg Leu Thr Phe Tyr Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Glu Asp Ser Gly Ser Val Ser Arg Tyr Val Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Val Asp Gln Val Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Ser Ser Pro Ala Ala Asp 
                165         


<210>  63

<211>  167
<212>  PRT
<213>  artificial sequence

<220>
<223>  pCLS3932_CAPNS1 I-CreI variant

<400>  63
Met Ala Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly 
1               5                   10                  15      


Phe Val Asp Gly Asp Gly Ser Ile Val Ala Gln Ile Lys Pro Asn Gln 
            20                  25                  30          


Arg Ala Lys Phe Lys His Gln Leu Ser Leu Thr Phe Gln Val Thr Gln 
        35                  40                  45              


Lys Thr Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly 
    50                  55                  60                  


Val Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Asn Tyr Arg Leu Ser 
65                  70                  75                  80  


Glu Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu 
                85                  90                  95      


Lys Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln 
            100                 105                 110         


Leu Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr 
        115                 120                 125             


Trp Ala Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr 
    130                 135                 140                 


Thr Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys 
145                 150                 155                 160 


Lys Pro Ser Pro Ala Ala Asp 
                165         


<210>  64
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Matrix heterologous sequence

<400>  64
aattgcggcc gcggtccggc gcgccttaa                                       29


<210>  65
<211>  5428
<212>  DNA
<213>  Artificial

<220>
<223>  pCLS003 empty vector

<400>  65
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg     60
ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg    120
cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc    180
ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt    240
gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata    300
tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc    360
cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc    420
attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt    480
atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt    540
atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca    600
tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg    660
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc    720
aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg    780
gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca    840
ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc    900
gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattctgc    960
agatatccag cacagtggcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca   1020
gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc   1080
ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg   1140
cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg   1200
gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag   1260
gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta   1320
agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg   1380
cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa   1440
gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc   1500
aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt   1560
cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca   1620
acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc   1680
tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg   1740
tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca   1800
tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa   1860
gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca   1920
tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt   1980
ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag   2040
gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg   2100
gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg   2160
caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa   2220
tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg   2280
tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt   2340
ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa   2400
gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc   2460
ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg   2520
ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg   2580
aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg   2640
aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg   2700
gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact   2760
gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg   2820
ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc   2880
ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct   2940
ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac   3000
cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat   3060
cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc   3120
ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc   3180
actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc   3240
gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg   3300
ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg   3360
tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc   3420
gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt   3480
gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct   3540
gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga   3600
taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc   3660
cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg   3720
ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg   3780
aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt   3840
tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt   3900
gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg   3960
cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact   4020
ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt   4080
cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct   4140
gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac   4200
cgctggtagc ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca   4260
agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta   4320
agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa   4380
atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg   4440
cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg   4500
actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc   4560
aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc   4620
cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa   4680
ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc   4740
cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg   4800
ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc   4860
cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat   4920
ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg   4980
tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc   5040
ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg   5100
aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat   5160
gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg   5220
gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg   5280
ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct   5340
catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac   5400
atttccccga aaagtgccac ctgacgtc                                      5428


<210>  66
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Si RNA DNMT1_1

<400>  66
acggtgctca tgcttacaac c                                               21


<210>  67
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Si RNA DNMT1_2

<400>  67
cccaatgaga ctgacatcaa a                                               21


<210>  68
<211>  6220
<212>  DNA
<213>  Artificial

<220>
<223>  pCLS2510 expressing XPC4 meganuclease

<400>  68
tcgagcgcta gcacccagct ttcttgtaca aagtggtgat ctagagggcc cgcggttcga     60
aggtaagcct atccctaacc ctctcctcgg tctcgattct acgcgtaccg gttagtaatg    120
agtttaaacg ggggaggcta actgaaacac ggaaggagac aataccggaa ggaacccgcg    180
ctatgacggc aataaaaaga cagaataaaa cgcacgggtg ttgggtcgtt tgttcataaa    240
cgcggggttc ggtcccaggg ctggcactct gtcgataccc caccgagacc ccattggggc    300
caatacgccc gcgtttcttc cttttcccca ccccaccccc caagttcggg tgaaggccca    360
gggctcgcag ccaacgtcgg ggcggcaggc cctgccatag cagatctgcg cagctggggc    420
tctagggggt atccccacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt    480
acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc    540
ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg gggcatccct    600
ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat    660
ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc    720
acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc    780
tattcttttg atttataagg gattttgggg atttcggcct attggttaaa aaatgagctg    840
atttaacaaa aatttaacgc gaattaattc tgtggaatgt gtgtcagtta gggtgtggaa    900
agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa    960
ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca   1020
attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca   1080
gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg   1140
ccgcctctgc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct   1200
tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcag cacgtgttga   1260
caattaatca tcggcatagt atatcggcat agtataatac gacaaggtga ggaactaaac   1320
catggccaag cctttgtctc aagaagaatc caccctcatt gaaagagcaa cggctacaat   1380
caacagcatc cccatctctg aagactacag cgtcgccagc gcagctctct ctagcgacgg   1440
ccgcatcttc actggtgtca atgtatatca ttttactggg ggaccttgtg cagaactcgt   1500
ggtgctgggc actgctgctg ctgcggcagc tggcaacctg acttgtatcg tcgcgatcgg   1560
aaatgagaac aggggcatct tgagcccctg cggacggtgc cgacaggtgc ttctcgatct   1620
gcatcctggg atcaaagcca tagtgaagga cagtgatgga cagccgacgg cagttgggat   1680
tcgtgaattg ctgccctctg gttatgtgtg ggagggctaa gcacttcgtg gccgaggagc   1740
aggactgaca cgtgctacga gatttcgatt ccaccgccgc cttctatgaa aggttgggct   1800
tcggaatcgt tttccgggac gccggctgga tgatcctcca gcgcggggat ctcatgctgg   1860
agttcttcgc ccaccccaac ttgtttattg cagcttataa tggttacaaa taaagcaata   1920
gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca   1980
aactcatcaa tgtatcttat catgtctgta taccgtcgac ctctagctag agcttggcgt   2040
aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca   2100
tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat   2160
taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt   2220
aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct   2280
cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa   2340
aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa   2400
aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc   2460
tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga   2520
caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc   2580
cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt   2640
ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct   2700
gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg   2760
agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta   2820
gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct   2880
acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa   2940
gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtttt tttgtttgca   3000
agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg   3060
ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa   3120
aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta   3180
tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag   3240
cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga   3300
tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac   3360
cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc   3420
ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta   3480
gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac   3540
gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat   3600
gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa   3660
gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg   3720
tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag   3780
aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc   3840
cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct   3900
caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat   3960
cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg   4020
ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc   4080
aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta   4140
tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg   4200
tcgacggatc gggagatctc ccgatcccct atggtgcact ctcagtacaa tctgctctga   4260
tgccgcatag ttaagccagt atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg   4320
cgcgagcaaa atttaagcta caacaaggca aggcttgacc gacaattgca tgaagaatct   4380
gcttagggtt aggcgttttg cgctgcttcg cgatgtacgg gccagatata cgcgttgaca   4440
ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata   4500
tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga   4560
cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt   4620
ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt   4680
gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca   4740
ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt   4800
catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt   4860
tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca   4920
ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg   4980
cggtaggcgt gtacggtggg aggtctatat aagcagagct ctctggctaa ctagagaacc   5040
cactgcttac tggcttatcg aaatgaattc gactcactgt tgggagaccc aagctggcta   5100
gttaagctat cacaagtttg tacaaaaaag caggctggcg cgccgaattc atggccaata   5160
ccaaatataa cgaagagttc ctgctgtacc tggccggctt tgtggacggt gacggtagca   5220
tcatcgctca gattaaacca aatcagtctc ataagtttaa acatgctcta cagttgacct   5280
ttaaggtgac tcaaaagacc cagcgccgtt ggtttctgga caaactagtg gatgaaattg   5340
gcgttggtta cgtacaggat agtggatccg tttccaacta catcttaagc gaaatcaagc   5400
cgctgcacaa cttcctgact caactgcagc cgtttctgga actgaaacag aaacaggcaa   5460
acctggccct gaaaattatc gaacagctgc cgtctgcaaa agaatccccg gacaaattcc   5520
tggaagtttg tacctgggtg gatcaggttg cagctctgaa cgattctaag acgcgtaaaa   5580
ccacttctga aaccgttcgt gctgtgctgg acagcctgag cgagaagaag aaatcctccc   5640
cggcggccgg tggatctgat aagtataatc aggctctgtc taaatacaac caagcactgt   5700
ccaagtacaa tcaggccctg tctggtggag gcggttccaa caaaaagttc ctgctgtatc   5760
ttgctggatt tgtggattct gatggctcca tcattgctca gataaaacca aatcaatctc   5820
acaagttcaa acaccagctc tccttggcct ttcaagtcac tcagaagaca caaagaaggt   5880
ggttcttgga caaattggtt gataggattg gtgtgggcta tgtcagagac agaggctctg   5940
tgtcagacta catcctgtct aaaattaagc ctcttcataa ctttctcacc caactgcaac   6000
ccttcttgaa gctcaaacag aagcaagcaa atctggtttt gaaaatcatc gagcaactgc   6060
catctgccaa ggagtcccct gacaagtttc ttgaagtgtg tacttgggtg gatcaggttg   6120
ctgccttgaa tgactccaag accagaaaaa ccacctctga gactgtgagg gcagttctgg   6180
atagcctctc tgagaagaaa aagtcctctc cttagagatc                         6220

























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