                                SEQUENCE LISTING

<110>  FUNDACIN CENTRO NACIONAL DE INVESTIGACIONES ONCOLGICAS CARLOS
       III;  UNIVERSITAT AUTONOMA DE BARCELONA

<120>  Telomerase Reverse Transcriptase for Protection Against Ageing
        
<130>  PCT-611

<150>  EP10168341
<151>  2010-07-02

<160>  22

<170>  SeqWin99, version 1.02

<210>  1
<211>  4018
<212>  DNA
<213>  Homo sapiens

<400>   1
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat   60
gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt   120
gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg   180
cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga   240
cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt   300
ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt   360
cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag   420
ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct   480
gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct   540
ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc   600
cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg   660
ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc   720
gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg   780
cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag   840
gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga   900
agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg   960
ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg   1020
tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct   1080
gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt   1140
ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg   1200
cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc   1260
gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc   1320
agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga   1380
ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt   1440
gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag   1500
gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc   1560
caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg   1620
caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct   1680
ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt   1740
ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg   1800
gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct   1860
gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact   1920
ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg   1980
agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact   2040
gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct   2100
gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga   2160
cccgccgcct gagctgtact ttgtcaaggt ggatgtgacg ggcgcgtacg acaccatccc   2220
ccaggacagg ctcacggagg tcatcgccag catcatcaaa ccccagaaca cgtactgcgt   2280
gcgtcggtat gccgtggtcc agaaggccgc ccatgggcac gtccgcaagg ccttcaagag   2340
ccacgtctct accttgacag acctccagcc gtacatgcga cagttcgtgg ctcacctgca   2400
ggagaccagc ccgctgaggg atgccgtcgt catcgagcag agctcctccc tgaatgaggc   2460
cagcagtggc ctcttcgacg tcttcctacg cttcatgtgc caccacgccg tgcgcatcag   2520
gggcaagtcc tacgtccagt gccaggggat cccgcagggc tccatcctct ccacgctgct   2580
ctgcagcctg tgctacggcg acatggagaa caagctgttt gcggggattc ggcgggacgg   2640
gctgctcctg cgtttggtgg atgatttctt gttggtgaca cctcacctca cccacgcgaa   2700
aaccttcctc aggaccctgg tccgaggtgt ccctgagtat ggctgcgtgg tgaacttgcg   2760
gaagacagtg gtgaacttcc ctgtagaaga cgaggccctg ggtggcacgg cttttgttca   2820
gatgccggcc cacggcctat tcccctggtg cggcctgctg ctggataccc ggaccctgga   2880
ggtgcagagc gactactcca gctatgcccg gacctccatc agagccagtc tcaccttcaa   2940
ccgcggcttc aaggctggga ggaacatgcg tcgcaaactc tttggggtct tgcggctgaa   3000
gtgtcacagc ctgtttctgg atttgcaggt gaacagcctc cagacggtgt gcaccaacat   3060
ctacaagatc ctcctgctgc aggcgtacag gtttcacgca tgtgtgctgc agctcccatt   3120
tcatcagcaa gtttggaaga accccacatt tttcctgcgc gtcatctctg acacggcctc   3180
cctctgctac tccatcctga aagccaagaa cgcagggatg tcgctggggg ccaagggcgc   3240
cgccggccct ctgccctccg aggccgtgca gtggctgtgc caccaagcat tcctgctcaa   3300
gctgactcga caccgtgtca cctacgtgcc actcctgggg tcactcagga cagcccagac   3360
gcagctgagt cggaagctcc cggggacgac gctgactgcc ctggaggccg cagccaaccc   3420
ggcactgccc tcagacttca agaccatcct ggactgatgg ccacccgccc acagccaggc   3480
cgagagcaga caccagcagc cctgtcacgc cgggctctac gtcccaggga gggaggggcg   3540
gcccacaccc aggcccgcac cgctgggagt ctgaggcctg agtgagtgtt tggccgaggc   3600
ctgcatgtcc ggctgaaggc tgagtgtccg gctgaggcct gagcgagtgt ccagccaagg   3660
gctgagtgtc cagcacacct gccgtcttca cttccccaca ggctggcgct cggctccacc   3720
ccagggccag cttttcctca ccaggagccc ggcttccact ccccacatag gaatagtcca   3780
tccccagatt cgccattgtt cacccctcgc cctgccctcc tttgccttcc acccccacca   3840
tccaggtgga gaccctgaga aggaccctgg gagctctggg aatttggagt gaccaaaggt   3900
gtgccctgta cacaggcgag gaccctgcac ctggatgggg gtccctgtgg gtcaaattgg   3960
ggggaggtgc tgtgggagta aaatactgaa tatatgagtt tttcagtttt gaaaaaaa     4018


<210>   2
<211>   1132
<212>   PRT
<213>   Homo sapiens

<400>   2
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      

His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          

Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              

Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  

Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  

Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      

Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         

Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             

Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 

Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 

Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     

Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         

Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             

Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 

Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 

Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     

Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         

Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             

Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 

Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 

Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     

Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         

Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             

Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 

Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 

Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     

Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         

Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             

Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 

Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 

Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     

Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         

Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             

Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 

Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 

Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     

Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         

Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             

His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 

Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 

Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     

Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         

Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             

Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 

Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 

Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     

Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         

Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             

Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 

Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 

Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     

Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         

Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             

Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 

Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 

Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     

Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         

Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             

Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 

Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 

Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     

Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         

Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile Leu Leu Leu Gln 
        995                 1000                1005            

Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro Phe His Gln Gln 
    1010                1015                1020                

Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile Ser Asp Thr Ala 
1025                1030                1035                1040

Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala Gly Met Ser Leu 
                1045                1050                1055    

Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu Ala Val Gln Trp 
            1060                1065                1070        

Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr Arg His Arg Val Thr 
        1075                1080                1085            

Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr Ala Gln Thr Gln Leu Ser 
    1090                1095                1100                

Arg Lys Leu Pro Gly Thr Thr Leu Thr Ala Leu Glu Ala Ala Ala Asn 
1105                1110                1115                1120

Pro Ala Leu Pro Ser Asp Phe Lys Thr Ile Leu Asp 
                1125                1130        


<210>   3
<211>   3982
<212>   DNA
<213>   Homo sapiens

<400>   3
caggcagcgc tgcgtcctgc tgcgcacgtg ggaagccctg gccccggcca cccccgcgat   60
gccgcgcgct ccccgctgcc gagccgtgcg ctccctgctg cgcagccact accgcgaggt   120
gctgccgctg gccacgttcg tgcggcgcct ggggccccag ggctggcggc tggtgcagcg   180
cggggacccg gcggctttcc gcgcgctggt ggcccagtgc ctggtgtgcg tgccctggga   240
cgcacggccg ccccccgccg ccccctcctt ccgccaggtg tcctgcctga aggagctggt   300
ggcccgagtg ctgcagaggc tgtgcgagcg cggcgcgaag aacgtgctgg ccttcggctt   360
cgcgctgctg gacggggccc gcgggggccc ccccgaggcc ttcaccacca gcgtgcgcag   420
ctacctgccc aacacggtga ccgacgcact gcgggggagc ggggcgtggg ggctgctgct   480
gcgccgcgtg ggcgacgacg tgctggttca cctgctggca cgctgcgcgc tctttgtgct   540
ggtggctccc agctgcgcct accaggtgtg cgggccgccg ctgtaccagc tcggcgctgc   600
cactcaggcc cggcccccgc cacacgctag tggaccccga aggcgtctgg gatgcgaacg   660
ggcctggaac catagcgtca gggaggccgg ggtccccctg ggcctgccag ccccgggtgc   720
gaggaggcgc gggggcagtg ccagccgaag tctgccgttg cccaagaggc ccaggcgtgg   780
cgctgcccct gagccggagc ggacgcccgt tgggcagggg tcctgggccc acccgggcag   840
gacgcgtgga ccgagtgacc gtggtttctg tgtggtgtca cctgccagac ccgccgaaga   900
agccacctct ttggagggtg cgctctctgg cacgcgccac tcccacccat ccgtgggccg   960
ccagcaccac gcgggccccc catccacatc gcggccacca cgtccctggg acacgccttg   1020
tcccccggtg tacgccgaga ccaagcactt cctctactcc tcaggcgaca aggagcagct   1080
gcggccctcc ttcctactca gctctctgag gcccagcctg actggcgctc ggaggctcgt   1140
ggagaccatc tttctgggtt ccaggccctg gatgccaggg actccccgca ggttgccccg   1200
cctgccccag cgctactggc aaatgcggcc cctgtttctg gagctgcttg ggaaccacgc   1260
gcagtgcccc tacggggtgc tcctcaagac gcactgcccg ctgcgagctg cggtcacccc   1320
agcagccggt gtctgtgccc gggagaagcc ccagggctct gtggcggccc ccgaggagga   1380
ggacacagac ccccgtcgcc tggtgcagct gctccgccag cacagcagcc cctggcaggt   1440
gtacggcttc gtgcgggcct gcctgcgccg gctggtgccc ccaggcctct ggggctccag   1500
gcacaacgaa cgccgcttcc tcaggaacac caagaagttc atctccctgg ggaagcatgc   1560
caagctctcg ctgcaggagc tgacgtggaa gatgagcgtg cgggactgcg cttggctgcg   1620
caggagccca ggggttggct gtgttccggc cgcagagcac cgtctgcgtg aggagatcct   1680
ggccaagttc ctgcactggc tgatgagtgt gtacgtcgtc gagctgctca ggtctttctt   1740
ttatgtcacg gagaccacgt ttcaaaagaa caggctcttt ttctaccgga agagtgtctg   1800
gagcaagttg caaagcattg gaatcagaca gcacttgaag agggtgcagc tgcgggagct   1860
gtcggaagca gaggtcaggc agcatcggga agccaggccc gccctgctga cgtccagact   1920
ccgcttcatc cccaagcctg acgggctgcg gccgattgtg aacatggact acgtcgtggg   1980
agccagaacg ttccgcagag aaaagagggc cgagcgtctc acctcgaggg tgaaggcact   2040
gttcagcgtg ctcaactacg agcgggcgcg gcgccccggc ctcctgggcg cctctgtgct   2100
gggcctggac gatatccaca gggcctggcg caccttcgtg ctgcgtgtgc gggcccagga   2160
cccgccgcct gagctgtact ttgtcaagga caggctcacg gaggtcatcg ccagcatcat   2220
caaaccccag aacacgtact gcgtgcgtcg gtatgccgtg gtccagaagg ccgcccatgg   2280
gcacgtccgc aaggccttca agagccacgt ctctaccttg acagacctcc agccgtacat   2340
gcgacagttc gtggctcacc tgcaggagac cagcccgctg agggatgccg tcgtcatcga   2400
gcagagctcc tccctgaatg aggccagcag tggcctcttc gacgtcttcc tacgcttcat   2460
gtgccaccac gccgtgcgca tcaggggcaa gtcctacgtc cagtgccagg ggatcccgca   2520
gggctccatc ctctccacgc tgctctgcag cctgtgctac ggcgacatgg agaacaagct   2580
gtttgcgggg attcggcggg acgggctgct cctgcgtttg gtggatgatt tcttgttggt   2640
gacacctcac ctcacccacg cgaaaacctt cctcaggacc ctggtccgag gtgtccctga   2700
gtatggctgc gtggtgaact tgcggaagac agtggtgaac ttccctgtag aagacgaggc   2760
cctgggtggc acggcttttg ttcagatgcc ggcccacggc ctattcccct ggtgcggcct   2820
gctgctggat acccggaccc tggaggtgca gagcgactac tccagctatg cccggacctc   2880
catcagagcc agtctcacct tcaaccgcgg cttcaaggct gggaggaaca tgcgtcgcaa   2940
actctttggg gtcttgcggc tgaagtgtca cagcctgttt ctggatttgc aggtgaacag   3000
cctccagacg gtgtgcacca acatctacaa gatcctcctg ctgcaggcgt acaggtttca   3060
cgcatgtgtg ctgcagctcc catttcatca gcaagtttgg aagaacccca catttttcct   3120
gcgcgtcatc tctgacacgg cctccctctg ctactccatc ctgaaagcca agaacgcagg   3180
gatgtcgctg ggggccaagg gcgccgccgg ccctctgccc tccgaggccg tgcagtggct   3240
gtgccaccaa gcattcctgc tcaagctgac tcgacaccgt gtcacctacg tgccactcct   3300
ggggtcactc aggacagccc agacgcagct gagtcggaag ctcccgggga cgacgctgac   3360
tgccctggag gccgcagcca acccggcact gccctcagac ttcaagacca tcctggactg   3420
atggccaccc gcccacagcc aggccgagag cagacaccag cagccctgtc acgccgggct   3480
ctacgtccca gggagggagg ggcggcccac acccaggccc gcaccgctgg gagtctgagg   3540
cctgagtgag tgtttggccg aggcctgcat gtccggctga aggctgagtg tccggctgag   3600
gcctgagcga gtgtccagcc aagggctgag tgtccagcac acctgccgtc ttcacttccc   3660
cacaggctgg cgctcggctc caccccaggg ccagcttttc ctcaccagga gcccggcttc   3720
cactccccac ataggaatag tccatcccca gattcgccat tgttcacccc tcgccctgcc   3780
ctcctttgcc ttccaccccc accatccagg tggagaccct gagaaggacc ctgggagctc   3840
tgggaatttg gagtgaccaa aggtgtgccc tgtacacagg cgaggaccct gcacctggat   3900
gggggtccct gtgggtcaaa ttggggggag gtgctgtggg agtaaaatac tgaatatatg   3960
agtttttcag ttttgaaaaa aa                                            3982


<210>   4
<211>   1120
<212>   PRT
<213>   Homo sapiens

<400>   4
Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      

His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          

Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              

Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  

Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  

Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      

Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         

Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             

Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 

Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 

Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     

Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         

Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             

Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 

Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 

Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     

Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         

Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             

Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 

Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 

Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     

Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         

Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             

Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 

Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 

Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     

Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         

Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             

Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 

Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 

Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     

Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         

Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             

Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 

Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 

Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     

Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         

Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             

His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 

Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 

Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     

Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         

Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             

Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 

Glu Leu Tyr Phe Val Lys Asp Arg Leu Thr Glu Val Ile Ala Ser Ile 
705                 710                 715                 720 

Ile Lys Pro Gln Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln 
                725                 730                 735     

Lys Ala Ala His Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser 
            740                 745                 750         

Thr Leu Thr Asp Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu 
        755                 760                 765             

Gln Glu Thr Ser Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser 
    770                 775                 780                 

Ser Leu Asn Glu Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe 
785                 790                 795                 800 

Met Cys His His Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys 
                805                 810                 815     

Gln Gly Ile Pro Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu 
            820                 825                 830         

Cys Tyr Gly Asp Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp 
        835                 840                 845             

Gly Leu Leu Leu Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His 
    850                 855                 860                 

Leu Thr His Ala Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro 
865                 870                 875                 880 

Glu Tyr Gly Cys Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro 
                885                 890                 895     

Val Glu Asp Glu Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala 
            900                 905                 910         

His Gly Leu Phe Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu 
        915                 920                 925             

Glu Val Gln Ser Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala 
    930                 935                 940                 

Ser Leu Thr Phe Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg 
945                 950                 955                 960 

Lys Leu Phe Gly Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp 
                965                 970                 975     

Leu Gln Val Asn Ser Leu Gln Thr Val Cys Thr Asn Ile Tyr Lys Ile 
            980                 985                 990         

Leu Leu Leu Gln Ala Tyr Arg Phe His Ala Cys Val Leu Gln Leu Pro 
        995                 1000                1005            

Phe His Gln Gln Val Trp Lys Asn Pro Thr Phe Phe Leu Arg Val Ile 
    1010                1015                1020                

Ser Asp Thr Ala Ser Leu Cys Tyr Ser Ile Leu Lys Ala Lys Asn Ala 
1025                1030                1035                1040

Gly Met Ser Leu Gly Ala Lys Gly Ala Ala Gly Pro Leu Pro Ser Glu 
                1045                1050                1055    

Ala Val Gln Trp Leu Cys His Gln Ala Phe Leu Leu Lys Leu Thr Arg 
            1060                1065                1070        

His Arg Val Thr Tyr Val Pro Leu Leu Gly Ser Leu Arg Thr Ala Gln 
        1075                1080                1085            

Thr Gln Leu Ser Arg Lys Leu Pro Gly Thr Thr Leu Thr Ala Leu Glu 
    1090                1095                1100                

Ala Ala Ala Asn Pro Ala Leu Pro Ser Asp Phe Lys Thr Ile Leu Asp 
1105                1110                1115                1120



<210>   5
<211>   3426
<212>   DNA
<213>   Mus musculus

<400>   5
gtgggaggcc catcccggcc ttgagcacaa tgacccgcgc tcctcgttgc cccgcggtgc   60
gctctctgct gcgcagccga taccgggagg tgtggccgct ggcaaccttt gtgcggcgcc   120
tggggcccga gggcaggcgg cttgtgcaac ccggggaccc gaagatctac cgcactttgg   180
ttgcccaatg cctagtgtgc atgcactggg gctcacagcc tccacctgcc gacctttcct   240
tccaccaggt gtcatccctg aaagagctgg tggccagggt tgtgcagaga ctctgcgagc   300
gcaacgagag aaacgtgctg gcttttggct ttgagctgct taacgaggcc agaggcgggc   360
ctcccatggc cttcactagt agcgtgcgta gctacttgcc caacactgtt attgagaccc   420
tgcgtgtcag tggtgcatgg atgctactgt tgagccgagt gggcgacgac ctgctggtct   480
acctgctggc acactgtgct ctttatcttc tggtgccccc cagctgtgcc taccaggtgt   540
gtgggtctcc cctgtaccaa atttgtgcca ccacggatat ctggccctct gtgtccgcta   600
gttacaggcc cacccgaccc gtgggcagga atttcactaa ccttaggttc ttacaacaga   660
tcaagagcag tagtcgccag gaagcaccga aacccctggc cttgccatct cgaggtacaa   720
agaggcatct gagtctcacc agtacaagtg tgccttcagc taagaaggcc agatgctatc   780
ctgtcccgag agtggaggag ggaccccaca ggcaggtgct accaacccca tcaggcaaat   840
catgggtgcc aagtcctgct cggtcccccg aggtgcctac tgcagagaaa gatttgtctt   900
ctaaaggaaa ggtgtctgac ctgagtctct ctgggtcggt gtgctgtaaa cacaagccca   960
gctccacatc tctgctgtca ccaccccgcc aaaatgcctt tcagctcagg ccatttattg   1020
agaccagaca tttcctttac tccaggggag atggccaaga gcgtctaaac ccctcattcc   1080
tactcagcaa cctccagcct aacttgactg gggccaggag actggtggag atcatctttc   1140
tgggctcaag gcctaggaca tcaggaccac tctgcaggac acaccgtcta tcgcgtcgat   1200
actggcagat gcggcccctg ttccaacagc tgctggtgaa ccatgcagag tgccaatatg   1260
tcagactcct caggtcacat tgcaggtttc gaacagcaaa ccaacaggtg acagatgcct   1320
tgaacaccag cccaccgcac ctcatggatt tgctccgcct gcacagcagt ccctggcagg   1380
tatatggttt tcttcgggcc tgtctctgca aggtggtgtc tgctagtctc tggggtacca   1440
ggcacaatga gcgccgcttc tttaagaact taaagaagtt catctcgttg gggaaatacg   1500
gcaagctatc actgcaggaa ctgatgtgga agatgaaagt agaggattgc cactggctcc   1560
gcagcagccc ggggaaggac cgtgtccccg ctgcagagca ccgtctgagg gagaggatcc   1620
tggctacgtt cctgttctgg ctgatggaca catacgtggt acagctgctt aggtcattct   1680
tttacatcac agagagcaca ttccagaaga acaggctctt cttctaccgt aagagtgtgt   1740
ggagcaagct gcagagcatt ggagtcaggc aacaccttga gagagtgcgg ctacgggagc   1800
tgtcacaaga ggaggtcagg catcaccagg acacctggct agccatgccc atctgcagac   1860
tgcgcttcat ccccaagccc aacggcctgc ggcccattgt gaacatgagt tatagcatgg   1920
gtaccagagc tttgggcaga aggaagcagg cccagcattt cacccagcgt ctcaagactc   1980
tcttcagcat gctcaactat gagcggacaa aacatcctca ccttatgggg tcttctgtac   2040
tgggtatgaa tgacatctac aggacctggc gggcctttgt gctgcgtgtg cgtgctctgg   2100
accagacacc caggatgtac tttgttaagg cagatgtgac cggggcctat gatgccatcc   2160
cccagggtaa gctggtggag gttgttgcca atatgatcag gcactcggag agcacgtact   2220
gtatccgcca gtatgcagtg gtccggagag atagccaagg ccaagtccac aagtccttta   2280
ggagacaggt caccaccctc tctgacctcc agccatacat gggccagttc cttaagcatc   2340
tgcaggattc agatgccagt gcactgagga actccgttgt catcgagcag agcatctcta   2400
tgaatgagag cagcagcagc ctgtttgact tcttcctgca cttcctgcgt cacagtgtcg   2460
taaagattgg tgacaggtgc tatacgcagt gccagggcat cccccagggc tccagcctat   2520
ccaccctgct ctgcagtctg tgtttcggag acatggagaa caagctgttt gctgaggtgc   2580
agcgggatgg gttgctttta cgttttgttg atgactttct gttggtgacg cctcacttgg   2640
accaagcaaa aaccttcctc agcaccctgg tccatggcgt tcctgagtat gggtgcatga   2700
taaacttgca gaagacagtg gtgaacttcc ctgtggagcc tggtaccctg ggtggtgcag   2760
ctccatacca gctgcctgct cactgcctgt ttccctggtg tggcttgctg ctggacactc   2820
agactttgga ggtgttctgt gactactcag gttatgccca gacctcaatt aagacgagcc   2880
tcaccttcca gagtgtcttc aaagctggga agaccatgcg gaacaagctc ctgtcggtct   2940
tgcggttgaa gtgtcacggt ctatttctag acttgcaggt gaacagcctc cagacagtct   3000
gcatcaatat atacaagatc ttcctgcttc aggcctacag gttccatgca tgtgtgattc   3060
agcttccctt tgaccagcgt gttaggaaga acctcacatt ctttctgggc atcatctcca   3120
gccaagcatc ctgctgctat gctatcctga aggtcaagaa tccaggaatg acactaaagg   3180
cctctggctc ctttcctcct gaagccgcac attggctctg ctaccaggcc ttcctgctca   3240
agctggctgc tcattctgtc atctacaaat gtctcctggg acctctgagg acagcccaaa   3300
aactgctgtg ccggaagctc ccagaggcga caatgaccat ccttaaagct gcagctgacc   3360
cagccctaag cacagacttt cagaccattt tggactaacc ctgtctcctt ccgctagatg   3420
aacatg                                                              3426


<210>   6
<211>   1122
<212>   PRT
<213>   Mus musculus

<400>   6
Met Thr Arg Ala Pro Arg Cys Pro Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      

Arg Tyr Arg Glu Val Trp Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          

Pro Glu Gly Arg Arg Leu Val Gln Pro Gly Asp Pro Lys Ile Tyr Arg 
        35                  40                  45              

Thr Leu Val Ala Gln Cys Leu Val Cys Met His Trp Gly Ser Gln Pro 
    50                  55                  60                  

Pro Pro Ala Asp Leu Ser Phe His Gln Val Ser Ser Leu Lys Glu Leu 
65                  70                  75                  80  

Val Ala Arg Val Val Gln Arg Leu Cys Glu Arg Asn Glu Arg Asn Val 
                85                  90                  95      

Leu Ala Phe Gly Phe Glu Leu Leu Asn Glu Ala Arg Gly Gly Pro Pro 
            100                 105                 110         

Met Ala Phe Thr Ser Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Ile 
        115                 120                 125             

Glu Thr Leu Arg Val Ser Gly Ala Trp Met Leu Leu Leu Ser Arg Val 
    130                 135                 140                 

Gly Asp Asp Leu Leu Val Tyr Leu Leu Ala His Cys Ala Leu Tyr Leu 
145                 150                 155                 160 

Leu Val Pro Pro Ser Cys Ala Tyr Gln Val Cys Gly Ser Pro Leu Tyr 
                165                 170                 175     

Gln Ile Cys Ala Thr Thr Asp Ile Trp Pro Ser Val Ser Ala Ser Tyr 
            180                 185                 190         

Arg Pro Thr Arg Pro Val Gly Arg Asn Phe Thr Asn Leu Arg Phe Leu 
        195                 200                 205             

Gln Gln Ile Lys Ser Ser Ser Arg Gln Glu Ala Pro Lys Pro Leu Ala 
    210                 215                 220                 

Leu Pro Ser Arg Gly Thr Lys Arg His Leu Ser Leu Thr Ser Thr Ser 
225                 230                 235                 240 

Val Pro Ser Ala Lys Lys Ala Arg Cys Tyr Pro Val Pro Arg Val Glu 
                245                 250                 255     

Glu Gly Pro His Arg Gln Val Leu Pro Thr Pro Ser Gly Lys Ser Trp 
            260                 265                 270         

Val Pro Ser Pro Ala Arg Ser Pro Glu Val Pro Thr Ala Glu Lys Asp 
        275                 280                 285             

Leu Ser Ser Lys Gly Lys Val Ser Asp Leu Ser Leu Ser Gly Ser Val 
    290                 295                 300                 

Cys Cys Lys His Lys Pro Ser Ser Thr Ser Leu Leu Ser Pro Pro Arg 
305                 310                 315                 320 

Gln Asn Ala Phe Gln Leu Arg Pro Phe Ile Glu Thr Arg His Phe Leu 
                325                 330                 335     

Tyr Ser Arg Gly Asp Gly Gln Glu Arg Leu Asn Pro Ser Phe Leu Leu 
            340                 345                 350         

Ser Asn Leu Gln Pro Asn Leu Thr Gly Ala Arg Arg Leu Val Glu Ile 
        355                 360                 365             

Ile Phe Leu Gly Ser Arg Pro Arg Thr Ser Gly Pro Leu Cys Arg Thr 
    370                 375                 380                 

His Arg Leu Ser Arg Arg Tyr Trp Gln Met Arg Pro Leu Phe Gln Gln 
385                 390                 395                 400 

Leu Leu Val Asn His Ala Glu Cys Gln Tyr Val Arg Leu Leu Arg Ser 
                405                 410                 415     

His Cys Arg Phe Arg Thr Ala Asn Gln Gln Val Thr Asp Ala Leu Asn 
            420                 425                 430         

Thr Ser Pro Pro His Leu Met Asp Leu Leu Arg Leu His Ser Ser Pro 
        435                 440                 445             

Trp Gln Val Tyr Gly Phe Leu Arg Ala Cys Leu Cys Lys Val Val Ser 
    450                 455                 460                 

Ala Ser Leu Trp Gly Thr Arg His Asn Glu Arg Arg Phe Phe Lys Asn 
465                 470                 475                 480 

Leu Lys Lys Phe Ile Ser Leu Gly Lys Tyr Gly Lys Leu Ser Leu Gln 
                485                 490                 495     

Glu Leu Met Trp Lys Met Lys Val Glu Asp Cys His Trp Leu Arg Ser 
            500                 505                 510         

Ser Pro Gly Lys Asp Arg Val Pro Ala Ala Glu His Arg Leu Arg Glu 
        515                 520                 525             

Arg Ile Leu Ala Thr Phe Leu Phe Trp Leu Met Asp Thr Tyr Val Val 
    530                 535                 540                 

Gln Leu Leu Arg Ser Phe Phe Tyr Ile Thr Glu Ser Thr Phe Gln Lys 
545                 550                 555                 560 

Asn Arg Leu Phe Phe Tyr Arg Lys Ser Val Trp Ser Lys Leu Gln Ser 
                565                 570                 575     

Ile Gly Val Arg Gln His Leu Glu Arg Val Arg Leu Arg Glu Leu Ser 
            580                 585                 590         

Gln Glu Glu Val Arg His His Gln Asp Thr Trp Leu Ala Met Pro Ile 
        595                 600                 605             

Cys Arg Leu Arg Phe Ile Pro Lys Pro Asn Gly Leu Arg Pro Ile Val 
    610                 615                 620                 

Asn Met Ser Tyr Ser Met Gly Thr Arg Ala Leu Gly Arg Arg Lys Gln 
625                 630                 635                 640 

Ala Gln His Phe Thr Gln Arg Leu Lys Thr Leu Phe Ser Met Leu Asn 
                645                 650                 655     

Tyr Glu Arg Thr Lys His Pro His Leu Met Gly Ser Ser Val Leu Gly 
            660                 665                 670         

Met Asn Asp Ile Tyr Arg Thr Trp Arg Ala Phe Val Leu Arg Val Arg 
        675                 680                 685             

Ala Leu Asp Gln Thr Pro Arg Met Tyr Phe Val Lys Ala Asp Val Thr 
    690                 695                 700                 

Gly Ala Tyr Asp Ala Ile Pro Gln Gly Lys Leu Val Glu Val Val Ala 
705                 710                 715                 720 

Asn Met Ile Arg His Ser Glu Ser Thr Tyr Cys Ile Arg Gln Tyr Ala 
                725                 730                 735     

Val Val Arg Arg Asp Ser Gln Gly Gln Val His Lys Ser Phe Arg Arg 
            740                 745                 750         

Gln Val Thr Thr Leu Ser Asp Leu Gln Pro Tyr Met Gly Gln Phe Leu 
        755                 760                 765             

Lys His Leu Gln Asp Ser Asp Ala Ser Ala Leu Arg Asn Ser Val Val 
    770                 775                 780                 

Ile Glu Gln Ser Ile Ser Met Asn Glu Ser Ser Ser Ser Leu Phe Asp 
785                 790                 795                 800 

Phe Phe Leu His Phe Leu Arg His Ser Val Val Lys Ile Gly Asp Arg 
                805                 810                 815     

Cys Tyr Thr Gln Cys Gln Gly Ile Pro Gln Gly Ser Ser Leu Ser Thr 
            820                 825                 830         

Leu Leu Cys Ser Leu Cys Phe Gly Asp Met Glu Asn Lys Leu Phe Ala 
        835                 840                 845             

Glu Val Gln Arg Asp Gly Leu Leu Leu Arg Phe Val Asp Asp Phe Leu 
    850                 855                 860                 

Leu Val Thr Pro His Leu Asp Gln Ala Lys Thr Phe Leu Ser Thr Leu 
865                 870                 875                 880 

Val His Gly Val Pro Glu Tyr Gly Cys Met Ile Asn Leu Gln Lys Thr 
                885                 890                 895     

Val Val Asn Phe Pro Val Glu Pro Gly Thr Leu Gly Gly Ala Ala Pro 
            900                 905                 910         

Tyr Gln Leu Pro Ala His Cys Leu Phe Pro Trp Cys Gly Leu Leu Leu 
        915                 920                 925             

Asp Thr Gln Thr Leu Glu Val Phe Cys Asp Tyr Ser Gly Tyr Ala Gln 
    930                 935                 940                 

Thr Ser Ile Lys Thr Ser Leu Thr Phe Gln Ser Val Phe Lys Ala Gly 
945                 950                 955                 960 

Lys Thr Met Arg Asn Lys Leu Leu Ser Val Leu Arg Leu Lys Cys His 
                965                 970                 975     

Gly Leu Phe Leu Asp Leu Gln Val Asn Ser Leu Gln Thr Val Cys Ile 
            980                 985                 990         

Asn Ile Tyr Lys Ile Phe Leu Leu Gln Ala Tyr Arg Phe His Ala Cys 
        995                 1000                1005            

Val Ile Gln Leu Pro Phe Asp Gln Arg Val Arg Lys Asn Leu Thr Phe 
    1010                1015                1020                

Phe Leu Gly Ile Ile Ser Ser Gln Ala Ser Cys Cys Tyr Ala Ile Leu 
1025                1030                1035                1040

Lys Val Lys Asn Pro Gly Met Thr Leu Lys Ala Ser Gly Ser Phe Pro 
                1045                1050                1055    

Pro Glu Ala Ala His Trp Leu Cys Tyr Gln Ala Phe Leu Leu Lys Leu 
            1060                1065                1070        

Ala Ala His Ser Val Ile Tyr Lys Cys Leu Leu Gly Pro Leu Arg Thr 
        1075                1080                1085            

Ala Gln Lys Leu Leu Cys Arg Lys Leu Pro Glu Ala Thr Met Thr Ile 
    1090                1095                1100                

Leu Lys Ala Ala Ala Asp Pro Ala Leu Ser Thr Asp Phe Gln Thr Ile 
1105                1110                1115                1120

Leu Asp 
        


<210>   7
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   7
ggcaccacac cttctacaat g                                             21


<210>   8
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   8
gtggtggtga agctgtag                                                 18


<210>   9
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   9
ggattgccac tggctccg                                                 18


<210>   10
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   10
tgcctgacct cctcttgtga c                                             21


<210>   11
<211>   20
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   11
cgtaccccga ttcaggtgat                                               20


<210>   12
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   12
ttgagcagaa gagctgctac gt                                            22


<210>   13
<211>   21
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   13
ggcaaagtgg agaggatcga c                                             21


<210>   14
<211>   18
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   14
tcgtggctgt tgcgtagg                                                 18


<210>   15
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   15
tgcgccctcc gtatcttac                                                19


<210>   16
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   16
atcttagagg ccacgaacat gc                                            22


<210>   17
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   17
cagcctactg gagatcagga tga                                           23


<210>   18
<211>   22
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   18
ggagtccttg gatgagtctc ga                                            22


<210>   19
<211>   24
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   19
gcgaactcac acaggcgaga aacc                                          24


<210>   20
<211>   23
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   20
tcgcttcctc ttcctccgac aca                                           23


<210>   21
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   21
cccattgccc ctgctcctg                                                19


<210>   22
<211>   19
<212>   DNA
<213>   Artificial Sequence

<220>
<223>   Primer

<400>   22
tgtgtccgcc ggtgtctgg                                                19


