                         SEQUENCE LISTING

<110>  Georg-August-Universitt Gttingen Stiftung ffentlichen 
       Rechts, Universittsmedizin
 
<120>  Pharmaceutical compositions and methods for induction and 
       enhancement of apoptosis in tumor cells

<130>  3294-48

<150>  US 12/829,803
<151>  2010-07-02

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can represent Ac-D-2Nal, Ac-2Nal, Ac-D3Pro

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can represent His, D-4Cpa, Arg, Tyr, Trp, D-4Fpa, D-4Bpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can represent Trp, D-3Pal, D-2Nal, Ala, Phe, His,

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can represent Tyr, His

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X can represent Gly, D-Lys, D-Cit, D-Trp, D-3Pal, D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can represent Trp, Leu, Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can represent Tyr, Leu, Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X can represent Gly, Ala, D-Ala, D-Gly, D-Cys, D-Ser, D-Val, 
       D-Thr, D-Pro, D-Ile, D-Leu

<400>  1

Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Pro Xaa 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3-Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  2

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  3
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-delta3Pro

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Ala-NH2

<400>  3

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  4
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  4

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  5
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  5

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  6
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  6

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Trp

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  7

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Ala-NH2

<400>  8

Xaa Xaa Xaa Ser Tyr Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Ala-NH2

<400>  9

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Cit

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Ala-NH2

<400>  10

Xaa Xaa Xaa Ser Tyr Xaa Trp Leu Pro Xaa 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  11

Xaa Xaa Ala Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3-Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  12

Xaa Xaa Phe Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  13
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3-Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  13

Xaa Xaa His Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents (4Cl)-D- Phe

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  14

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  15

Xaa Arg Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3-Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  16

Xaa Tyr Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  artificial Sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2 Nal

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents Gly-NH2

<400>  17

Xaa Trp Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  homo sapiens


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  pGlu

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Gly-NH2

<400>  18

Glu His Trp Ser His Gly Trp Tyr Pro Gly 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  19

Xaa Xaa Xaa Ser His Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  20

Xaa Xaa Xaa Ser His Xaa Trp Leu Pro Xaa 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  21

Xaa Xaa Xaa Ser Tyr Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-Lys

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  22

Xaa Xaa Xaa Ser Tyr Xaa Trp Leu Pro Xaa 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  23

Xaa Xaa Xaa Ser His Xaa Trp Leu Pro Xaa 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  24

Xaa Xaa Xaa Ser Tyr Xaa Trp Tyr Pro Xaa 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X represents Ac-D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X represents D-4Cpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X represents D-3Pal

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X represents D-Ala-NH2

<400>  25

Xaa Xaa Xaa Ser Tyr Xaa Trp Leu Pro Xaa 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  GnRH II antagonist


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can represent Ac-D-2Nal, Ac-delta3Pro

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X can represent His, D-4Cpa, Arg, Tyr, Trp, D-4Fpa, D-4Bpa

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X can represent Trp, D-3Pal, D-2Nal, Ala, Phe, His

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can represent Tyr, His

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X can represent D-Lys, D-Trp, D-3Pal, D-2Nal

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X can represent Trp, Leu, Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X can represent Tyr, Leu, Arg

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X can represent D-Ala, D-Gly, D-Cys, D-Ser, D-Val, D-Thr, D-Pro, 
       D-Ile, D-Leu

<400>  26

Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Pro Xaa 
1               5                   10  


