                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  LLT-1 antibodies with new functional properties

<130>  8213.204-WO

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  1

Met His Asp Ser Asn Asn Val Glu Lys Asp Ile Thr Pro Ser Glu Leu 
1               5                   10                  15      


Pro Ala Asn Pro Gly Cys Leu His Ser Lys Glu His Ser Ile Lys Ala 
            20                  25                  30          


Thr Leu Ile Trp Arg Leu Phe Phe Leu Ile Met Phe Leu Thr Ile Ile 
        35                  40                  45              


Val Cys Gly Met Val Ala Ala Leu Ser Ala Ile Arg Ala Asn Cys His 
    50                  55                  60                  


Gln Glu Pro Ser Val Cys Leu Gln Ala Ala Cys Pro Glu Ser Trp Ile 
65                  70                  75                  80  


Gly Phe Gln Arg Lys Cys Phe Tyr Phe Ser Asp Asp Thr Lys Asn Trp 
                85                  90                  95      


Thr Ser Ser Gln Arg Phe Cys Asp Ser Gln Asp Ala Asp Leu Ala Gln 
            100                 105                 110         


Val Glu Ser Phe Gln Glu Leu Asn Phe Leu Leu Arg Tyr Lys Gly Pro 
        115                 120                 125             


Ser Asp His Trp Ile Gly Leu Ser Arg Glu Gln Gly Gln Pro Trp Lys 
    130                 135                 140                 


Trp Ile Asn Gly Thr Glu Trp Thr Arg Gln Phe Pro Ile Leu Gly Ala 
145                 150                 155                 160 


Gly Glu Cys Ala Tyr Leu Asn Asp Lys Gly Ala Ser Ser Ala Arg His 
                165                 170                 175     


Tyr Thr Glu Arg Lys Trp Ile Cys Ser Lys Ser Asp Ile His Val 
            180                 185                 190     


<210>  2
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain (VH) of anti-LLT14F68

<400>  2
gaggtgcagc tggtggagtc tgggggaggc ttagtgcagc ctggagggtc cctgaaactc       60

tcctgcgcag cctctggatt cactgtcagt agctatggca tgtcttgggt tcgccagatt      120

ccagacaaga ggctggagtt ggtcgcaacc attaatagta atggtggtag gaccttttat      180

ccagacagtg tgaagggccg attcaccatc tccagagaca atgcccagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt attactgtgc aagagatggg      300

gggtactggg cccactttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  3
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain (VH) of anti-LLT14F68

<400>  3
ctccacgtcg accacctcag accccctccg aatcacgtcg gacctcccag ggactttgag       60

aggacgcgtc ggagacctaa gtgacagtca tcgataccgt acagaaccca agcggtctaa      120

ggtctgttct ccgacctcaa ccagcgttgg taattatcat taccaccatc ctggaaaata      180

ggtctgtcac acttcccggc taagtggtag aggtctctgt tacgggtctt gtgggacatg      240

gacgtttact cgtcagactt cagactcctg tgtcggtaca taatgacacg ttctctaccc      300

cccatgaccc gggtgaaact gatgaccccg gttccgtggt gagagtgtca gaggagt         357


<210>  4
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain (VH) of anti-LLT14F68

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ile Pro Asp Lys Arg Leu Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Asn Ser Asn Gly Gly Arg Thr Phe Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gly Tyr Trp Ala His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  5
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain (VL) of anti-LLT14F68

<400>  5
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaacgg                             339


<210>  6
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain (VL) of anti-LLT14F68

<400>  6
ctacaaaact actgggtttg aggtgagagg gacggacagt cagaacctct agttcggagg       60

tagagaacgt ctagatcagt ctcgtaacat gtatcattac ctttgtggat aaatcttacc      120

atggacgtct ttggtccggt cagaggtttc gaggactaga tgtttcaaag gttggctaaa      180

agaccccagg gtctgtccaa gtcaccgtca cctagtccct gtctaaagtg tgagttctag      240

tcgtctcacc tccgactcct agaccctcaa ataatgacga aagttccaag tgtacaaggc      300

acctgcaagc cacctccgtg gttcgacctt tagtttgcc                             339


<210>  7
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain (VL) of anti-LLT14F68

<400>  7

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  8
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain (VH) of anti-LLT12F1A5

<400>  8
gaggttcagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactactata tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcaa ggccactgtg actgcagaca catcctccaa cacagtctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtaa tggagagatt      300

attacgacta ctgcctggtt tacttactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  9
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  Heavy chain variable domain (VH) of anti-LLT12F1A5

<400>  9
ctccaagtcg acgtcgtcag accccgtctc gaacactcca gtccccggag tcagttcaac       60

aggacgtgtc gaagaccgaa gttgtaattt ctgatgatat acgtgaccca cttcgtctcc      120

ggacttgtcc cggacctcac ctaacctacc taactaggac tcttaccact atgacttata      180

cggggcttca aggtcccgtt ccggtgacac tgacgtctgt gtaggaggtt gtgtcagatg      240

gacgtcgagt cgtcggactg tagactcctg tgacggcaga taatgacatt acctctctaa      300

taatgctgat gacggaccaa atgaatgacc ccggttccct gagaccagtg acagagacgt      360


<210>  10
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable domain (VH) of anti-LLT12F1A5

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Val Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Gly Glu Ile Ile Thr Thr Thr Ala Trp Phe Thr Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  11
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain (VL) of anti-LLT12F1A5

<400>  11
gatattgtga tgacccagac tccaatcagt ttgtcggtta ccattggaca accagcttcc       60

atctcttgca agtcaagtca gagcctctta tatactaatg gaaaaaccta tttgaattgg      120

ttattacaga ggccaggcca gtctccaaaa cgcctaatct atctggtgtc taaattggac      180

tctggagtcc ctgacaggtt cagtggcagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattactgct tgcagaatac acattttcct      300

cacacgttcg gaggggggac caagctggaa ataaaacgg                             339


<210>  12
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  Light chain variable domain (VL) of anti-LLT12F1A5

<400>  12
ctataacact actgggtctg aggttagtca aacagccaat ggtaacctgt tggtcgaagg       60

tagagaacgt tcagttcagt ctcggagaat atatgattac ctttttggat aaacttaacc      120

aataatgtct ccggtccggt cagaggtttt gcggattaga tagaccacag atttaacctg      180

agacctcagg gactgtccaa gtcaccgtca cctagtccct gtctaaagtg tgacttttag      240

tcgtctcacc tccgactcct aaaccctcaa ataatgacga acgtcttatg tgtaaaagga      300

gtgtgcaagc ctcccccctg gttcgacctt tattttgcc                             339


<210>  13
<211>  113
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable domain (VL) of anti-LLT12F1A5

<400>  13

Asp Ile Val Met Thr Gln Thr Pro Ile Ser Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Thr 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Leu Gln Asn 
                85                  90                  95      


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


