                         SEQUENCE LISTING

<110>  Universittsklinikum Freiburg
 
<120>  Blockade of CCL18 Signaling via CCR6 as a Therapeutic Option in 
       Fibrotic Diseases and Cancer

<130>  U7282/DB

<150>  EP10167496.8
<151>  2010-06-28

<150>  EP11169326.3
<151>  2011-06-09

<160>  27    

<170>  PatentIn version 3.3

<210>  1
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  N-terminal domain of human CCR6 receptor

<400>  1

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


<210>  2
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  first extracellular loop of human CCR6 receptor

<400>  2

Ser His Ala Thr Gly Ala Trp Val Phe Ser Asn Ala Thr Cys Lys Leu 
1               5                   10                  15      


Leu Lys Gly 
            


<210>  3
<211>  3216
<212>  DNA
<213>  Homo sapiens

<400>  3
agtgtatggg tgaaggaggc agcagtgtgg ccggagagga gagctgggct gggagcacag     60

gaaggtcccc aggactctgt ggtcatcagt aagagagggc ccacgtgtat atgctggtga    120

acagaaatgt caaccttttc aaagtctgac atttaagaga aaaaactgtg gctgttggtt    180

tgtggaacag acagctcctt ctttattgag tcacctctac tttcctgcta ccgctgcctg    240

tgagctgaag gggctgaacc atacactcct ttttctacaa ccagcttgca ttttttctgc    300

ccacaatgag cggggaatca atgaatttca gcgatgtttt cgactccagt gaagattatt    360

ttgtgtcagt caatacttca tattactcag ttgattctga gatgttactg tgctccttgc    420

aggaggtcag gcagttctcc aggctatttg taccgattgc ctactccttg atctgtgtct    480

ttggcctcct ggggaatatt ctggtggtga tcacctttgc tttttataag aaggccaggt    540

ctatgacaga cgtctatctc ttgaacatgg ccattgcaga catcctcttt gttcttactc    600

tcccattctg ggcagtgagt catgccaccg gtgcgtgggt tttcagcaat gccacgtgca    660

agttgctaaa aggcatctat gccatcaact ttaactgcgg gatgctgctc ctgacttgca    720

ttagcatgga ccggtacatc gccattgtac aggcgactaa gtcattccgg ctccgatcca    780

gaacactacc gcgcagcaaa atcatctgcc ttgttgtgtg ggggctgtca gtcatcatct    840

ccagctcaac ttttgtcttc aaccaaaaat acaacaccca aggcagcgat gtctgtgaac    900

ccaagtacca gactgtctcg gagcccatca ggtggaagct gctgatgttg gggcttgagc    960

tactctttgg tttctttatc cctttgatgt tcatgatatt ttgttacacg ttcattgtca   1020

aaaccttggt gcaagctcag aattctaaaa ggcacaaagc catccgtgta atcatagctg   1080

tggtgcttgt gtttctggct tgtcagattc ctcataacat ggtcctgctt gtgacggctg   1140

caaatttggg taaaatgaac cgatcctgcc agagcgaaaa gctaattggc tatacgaaaa   1200

ctgtcacaga agtcctggct ttcctgcact gctgcctgaa ccctgtgctc tacgctttta   1260

ttgggcagaa gttcagaaac tactttctga agatcttgaa ggacctgtgg tgtgtgagaa   1320

ggaagtacaa gtcctcaggc ttctcctgtg ccgggaggta ctcagaaaac atttctcggc   1380

agaccagtga gaccgcagat aacgacaatg cgtcgtcctt cactatgtga tagaaagctg   1440

agtctcccta aggcatgtgt gaaacatact catagatgtt atgcaaaaaa aagtctatgg   1500

ccaggtatgc atggaaaatg tgggaattaa gcaaaatcaa gcaagcctct ctcctgcggg   1560

acttaacgtg ctcatgggct gtgtgatctc ttcagggtgg ggtggtctct gataggtagc   1620

attttccagc actttgcaag gaatgttttg tagctctagg gtatatatcc gcctggcatt   1680

tcacaaaaca gcctttggga aatgctgaat taaagtgaat tgttgacaaa tgtaaacatt   1740

ttcagaaata ttcatgaagc ggtcacagat cacagtgtct tttggttaca gcacaaaatg   1800

atggcagtgg tttgaaaaac taaaacagaa aaaaaaatgg aagccaacac atcactcatt   1860

ttaggcaaat gtttaaacat ttttatctat cagaatgttt attgttgctg gttataagca   1920

gcaggattgg ccggctagtg tttcctctca tttccctttg atacagtcaa caagcctgac   1980

cctgtaaaat ggaggtggaa agacaagctc aagtgttcac aacctggaag tgcttcggga   2040

agaaggggac aatggcagaa caggtgttgg tgacaattgt caccaattgg ataaagcagc   2100

tcaggttgta gtgggccatt aggaaactgt cggtttgctt tgatttccct gggagctgtt   2160

ctctgtcgtg agtgtctctt gtctaaacgt ccattaagct gagagtgcta tgaagacagg   2220

atctagaata atcttgctca cagctgtgct ctgagtgcct agcggagttc cagcaaacaa   2280

aatggactca agagagattt gattaatgaa tcgtaatgaa gttggggttt attgtacagt   2340

ttaaaatgtt agatgttttt aattttttaa ataaatggaa tacttttttt ttttttttaa   2400

agaaagcaac tttactgaga caatgtagaa agaagttttg ttccgtttct ttaatgtggt   2460

tgaagagcaa tgtgtggctg aagacttttg ttatgaggag ctgcagatta gctaggggac   2520

agctggaatt atgctggctt ctgataatta ttttaaaggg gtctgaaatt tgtgatggaa   2580

tcagatttta acagctctct tcaatgacat agaaagttca tggaactcat gtttttaaag   2640

ggctatgtaa atatatgaac attagaaaaa tagcaacttg tgttacaaaa atacaaacac   2700

atgttaggaa ggtactgtca tgggctaggc atggtggctc acacctgtaa tcccagcatt   2760

ttgggaagct aagatgggtg gatcacttga ggtcaggagt ttgagaccag cctggccaac   2820

atggcgaaac ccctctctac taaaaataca aaaatttgcc aggcgtggtg gcgggtgcct   2880

gtaatcccag ctacttggga ggctgaggca agagaatcgc ttgaacccag gaggcagagg   2940

ttgcagtgag ccgagatcgt gccattgcac tccagcctgg gtgacaaagc gagactccat   3000

ctcaaaaaaa aaaaaaaaaa aaaaggaaag aactgtcatg taaacatacc aacatgttta   3060

aacctgacaa tggtgttatt tgaaacttta tattgttctt gtaagcttta actatatctc   3120

tctttaaaat gcaaaataat gtcttaagat tcaaagtctg tatttttaaa gcatggcttt   3180

ggctttgcaa aataaaaaat gtgttttgta catgaa                             3216


<210>  4
<211>  3479
<212>  DNA
<213>  Homo sapiens

<400>  4
aactcacacg gcctcttgca aacgttccca aatcttccca gtcggcttgc agagactcct     60

tgctcccagg agataaccag gtaaaggagt atgaaagttt gggtacaaac tcattgctgc    120

aaattgaaaa ccatgcaaag gctgtcttcc tctggggagt tcaatgcctc tctttttctt    180

atcactttac cattggttgg actttgattc cagggatcct acgattactc aataccctac    240

aggatataca tggttaacca tttgcatttg ggcaaatagg cgttactttt caataggaag    300

tggcaatcca gaacttgctt ttgggcaatt ctagtagctc accgcttttt tcttaatgac    360

tgctagaagc tgcatcttat tgacagatgg tcatcacatt ggtgagctgg agtcatcaga    420

ttgtggggcc cggagtgagg ctgaagggag tggatcagag cactgcctga gagtcacctc    480

tactttcctg ctaccgctgc ctgtgagctg aaggggctga accatacact cctttttcta    540

caaccagctt gcattttttc tgcccacaat gagcggggaa tcaatgaatt tcagcgatgt    600

tttcgactcc agtgaagatt attttgtgtc agtcaatact tcatattact cagttgattc    660

tgagatgtta ctgtgctcct tgcaggaggt caggcagttc tccaggctat ttgtaccgat    720

tgcctactcc ttgatctgtg tctttggcct cctggggaat attctggtgg tgatcacctt    780

tgctttttat aagaaggcca ggtctatgac agacgtctat ctcttgaaca tggccattgc    840

agacatcctc tttgttctta ctctcccatt ctgggcagtg agtcatgcca ccggtgcgtg    900

ggttttcagc aatgccacgt gcaagttgct aaaaggcatc tatgccatca actttaactg    960

cgggatgctg ctcctgactt gcattagcat ggaccggtac atcgccattg tacaggcgac   1020

taagtcattc cggctccgat ccagaacact accgcgcagc aaaatcatct gccttgttgt   1080

gtgggggctg tcagtcatca tctccagctc aacttttgtc ttcaaccaaa aatacaacac   1140

ccaaggcagc gatgtctgtg aacccaagta ccagactgtc tcggagccca tcaggtggaa   1200

gctgctgatg ttggggcttg agctactctt tggtttcttt atccctttga tgttcatgat   1260

attttgttac acgttcattg tcaaaacctt ggtgcaagct cagaattcta aaaggcacaa   1320

agccatccgt gtaatcatag ctgtggtgct tgtgtttctg gcttgtcaga ttcctcataa   1380

catggtcctg cttgtgacgg ctgcaaattt gggtaaaatg aaccgatcct gccagagcga   1440

aaagctaatt ggctatacga aaactgtcac agaagtcctg gctttcctgc actgctgcct   1500

gaaccctgtg ctctacgctt ttattgggca gaagttcaga aactactttc tgaagatctt   1560

gaaggacctg tggtgtgtga gaaggaagta caagtcctca ggcttctcct gtgccgggag   1620

gtactcagaa aacatttctc ggcagaccag tgagaccgca gataacgaca atgcgtcgtc   1680

cttcactatg tgatagaaag ctgagtctcc ctaaggcatg tgtgaaacat actcatagat   1740

gttatgcaaa aaaaagtcta tggccaggta tgcatggaaa atgtgggaat taagcaaaat   1800

caagcaagcc tctctcctgc gggacttaac gtgctcatgg gctgtgtgat ctcttcaggg   1860

tggggtggtc tctgataggt agcattttcc agcactttgc aaggaatgtt ttgtagctct   1920

agggtatata tccgcctggc atttcacaaa acagcctttg ggaaatgctg aattaaagtg   1980

aattgttgac aaatgtaaac attttcagaa atattcatga agcggtcaca gatcacagtg   2040

tcttttggtt acagcacaaa atgatggcag tggtttgaaa aactaaaaca gaaaaaaaaa   2100

tggaagccaa cacatcactc attttaggca aatgtttaaa catttttatc tatcagaatg   2160

tttattgttg ctggttataa gcagcaggat tggccggcta gtgtttcctc tcatttccct   2220

ttgatacagt caacaagcct gaccctgtaa aatggaggtg gaaagacaag ctcaagtgtt   2280

cacaacctgg aagtgcttcg ggaagaaggg gacaatggca gaacaggtgt tggtgacaat   2340

tgtcaccaat tggataaagc agctcaggtt gtagtgggcc attaggaaac tgtcggtttg   2400

ctttgatttc cctgggagct gttctctgtc gtgagtgtct cttgtctaaa cgtccattaa   2460

gctgagagtg ctatgaagac aggatctaga ataatcttgc tcacagctgt gctctgagtg   2520

cctagcggag ttccagcaaa caaaatggac tcaagagaga tttgattaat gaatcgtaat   2580

gaagttgggg tttattgtac agtttaaaat gttagatgtt tttaattttt taaataaatg   2640

gaatactttt tttttttttt taaagaaagc aactttactg agacaatgta gaaagaagtt   2700

ttgttccgtt tctttaatgt ggttgaagag caatgtgtgg ctgaagactt ttgttatgag   2760

gagctgcaga ttagctaggg gacagctgga attatgctgg cttctgataa ttattttaaa   2820

ggggtctgaa atttgtgatg gaatcagatt ttaacagctc tcttcaatga catagaaagt   2880

tcatggaact catgttttta aagggctatg taaatatatg aacattagaa aaatagcaac   2940

ttgtgttaca aaaatacaaa cacatgttag gaaggtactg tcatgggcta ggcatggtgg   3000

ctcacacctg taatcccagc attttgggaa gctaagatgg gtggatcact tgaggtcagg   3060

agtttgagac cagcctggcc aacatggcga aacccctctc tactaaaaat acaaaaattt   3120

gccaggcgtg gtggcgggtg cctgtaatcc cagctacttg ggaggctgag gcaagagaat   3180

cgcttgaacc caggaggcag aggttgcagt gagccgagat cgtgccattg cactccagcc   3240

tgggtgacaa agcgagactc catctcaaaa aaaaaaaaaa aaaaaaagga aagaactgtc   3300

atgtaaacat accaacatgt ttaaacctga caatggtgtt atttgaaact ttatattgtt   3360

cttgtaagct ttaactatat ctctctttaa aatgcaaaat aatgtcttaa gattcaaagt   3420

ctgtattttt aaagcatggc tttggctttg caaaataaaa aatgtgtttt gtacatgaa    3479


<210>  5
<211>  793
<212>  DNA
<213>  Homo sapiens

<400>  5
aggagttgtg agtttccaag ccccagctca ctctgaccac ttctctgcct gcccagcatc     60

atgaagggcc ttgcagctgc cctccttgtc ctcgtctgca ccatggccct ctgctcctgt    120

gcacaagttg gtaccaacaa agagctctgc tgcctcgtct atacctcctg gcagattcca    180

caaaagttca tagttgacta ttctgaaacc agcccccagt gccccaagcc aggtgtcatc    240

ctcctaacca agagaggccg gcagatctgt gctgacccca ataagaagtg ggtccagaaa    300

tacatcagcg acctgaagct gaatgcctga ggggcctgga agctgcgagg gcccagtgaa    360

cttggtgggc ccaggaggga acaggagcct gagccagggc aatggccctg ccaccctgga    420

ggccacctct tctaagagtc ccatctgcta tgcccagcca cattaactaa ctttaatctt    480

agtttatgca tcatatttca ttttgaaatt gatttctatt gttgagctgc attatgaaat    540

tagtattttc tctgacatct catgacattg tctttatcat cctttcccct ttcccttcaa    600

ctcttcgtac attcaatgca tggatcaatc agtgtgatta gctttctcag cagacattgt    660

gccatatgta tcaaatgaca aatctttatt gaatggtttt gctcagcacc accttttaat    720

atattggcag tacttattat ataaaaggta aaccagcatt ctcactgtga aaaaaaaaaa    780

aaaaaaaaaa aaa                                                       793


<210>  6
<211>  851
<212>  DNA
<213>  Homo sapiens

<400>  6
agaatataac agcactccca aagaactggg tactcaacac tgagcagatc tgttctttga     60

gctaaaaacc atgtgctgta ccaagagttt gctcctggct gctttgatgt cagtgctgct    120

actccacctc tgcggcgaat cagaagcagc aagcaacttt gactgctgtc ttggatacac    180

agaccgtatt cttcatccta aatttattgt gggcttcaca cggcagctgg ccaatgaagg    240

ctgtgacatc aatgctatca tctttcacac aaagaaaaag ttgtctgtgt gcgcaaatcc    300

aaaacagact tgggtgaaat atattgtgcg tctcctcagt aaaaaagtca agaacatgta    360

aaaactgtgg cttttctgga atggaattgg acatagccca agaacagaaa gaaccttgct    420

ggggttggag gtttcacttg cacatcatgg agggtttagt gcttatctaa tttgtgcctc    480

actggacttg tccaattaat gaagttgatt catattgcat catagtttgc tttgtttaag    540

catcacatta aagttaaact gtattttatg ttatttatag ctgtaggttt tctgtgttta    600

gctatttaat actaattttc cataagctat tttggtttag tgcaaagtat aaaattatat    660

ttggggggga ataagattat atggactttc ttgcaagcaa caagctattt tttaaaaaaa    720

actatttaac attcttttgt ttatattgtt ttgtctccta aattgttgta attgcattat    780

aaaataagaa aaatattaat aagacaaata ttgaaaataa agaaacaaaa agttcttctg    840

ttaaaaaaaa a                                                         851


<210>  7
<211>  848
<212>  DNA
<213>  Homo sapiens

<400>  7
agaatataac agcactccca aagaactggg tactcaacac tgagcagatc tgttctttga     60

gctaaaaacc atgtgctgta ccaagagttt gctcctggct gctttgatgt cagtgctgct    120

actccacctc tgcggcgaat cagaagcaag caactttgac tgctgtcttg gatacacaga    180

ccgtattctt catcctaaat ttattgtggg cttcacacgg cagctggcca atgaaggctg    240

tgacatcaat gctatcatct ttcacacaaa gaaaaagttg tctgtgtgcg caaatccaaa    300

acagacttgg gtgaaatata ttgtgcgtct cctcagtaaa aaagtcaaga acatgtaaaa    360

actgtggctt ttctggaatg gaattggaca tagcccaaga acagaaagaa ccttgctggg    420

gttggaggtt tcacttgcac atcatggagg gtttagtgct tatctaattt gtgcctcact    480

ggacttgtcc aattaatgaa gttgattcat attgcatcat agtttgcttt gtttaagcat    540

cacattaaag ttaaactgta ttttatgtta tttatagctg taggttttct gtgtttagct    600

atttaatact aattttccat aagctatttt ggtttagtgc aaagtataaa attatatttg    660

ggggggaata agattatatg gactttcttg caagcaacaa gctatttttt aaaaaaaact    720

atttaacatt cttttgttta tattgttttg tctcctaaat tgttgtaatt gcattataaa    780

ataagaaaaa tattaataag acaaatattg aaaataaaga aacaaaaagt tcttctgtta    840

aaaaaaaa                                                             848


<210>  8
<211>  144
<212>  DNA
<213>  Artificial

<220>
<223>  polynucleotide sequence encoding polypeptide according to SEQ ID 
       NO.:1

<400>  8
atgagcgggg aatcaatgaa tttcagcgat gttttcgact ccagtgaaga ttattttgtg     60

tcagtcaata cttcatatta ctcagttgat tctgagatgt tactgtgctc cttgcaggag    120

gtcaggcagt tctccaggct attt                                           144


<210>  9
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  peptide inhibitor of CCR6

<400>  9

Glu Asp Cys Cys Leu Val Tyr Thr Ser Trp Gln Ile His Pro Lys Phe 
1               5                   10                  15      


Ile Val Asp Tyr Ser Glu Thr Ser Pro Gln Cys Pro Lys 
            20                  25                  


<210>  10
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer GAPDH

<400>  10
caccagggct gcttttaact                                                 20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer GAPDH

<400>  11
gatctcgctc ctggaagatg                                                 20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer CCR6

<400>  12
gcacaaaatg atggcagtgg                                                 20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer CCR6

<400>  13
ccgaagcact tccaggttgt                                                 20


<210>  14
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer collagen type I

<400>  14
ccctgtctgc ttcctgtaaa ct                                              22


<210>  15
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer collagen type I

<400>  15
catgttcggt tggtcaaaga ta                                              22


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  forward primer alphaSMA

<400>  16
catcatgcgt ctggatctgg                                                 20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  reverse primer alphaSMA

<400>  17
ggacaatctc acgctcagca                                                 20


<210>  18
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  18

Ala Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu Val Tyr Thr Ser 
1               5                   10                  15      


Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser Glu Thr Ser Pro 
            20                  25                  30          


Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys Arg Gly Arg Gln 
        35                  40                  45              


Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys Tyr Ile Ser Asp 
    50                  55                  60                  


Leu Lys Leu Asn Ala 
65                  


<210>  19
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Ser Asn Phe Asp Cys Cys Leu Gly Tyr Thr Asp Arg Ile Leu His 
1               5                   10                  15      


Pro Lys Phe Ile Val Gly Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys 
            20                  25                  30          


Asp Ile Asn Ala Ile Ile Phe His Thr Lys Lys Lys Leu Ser Val Cys 
        35                  40                  45              


Ala Asn Pro Lys Gln Thr Trp Val Lys Tyr Ile Val Arg Leu Leu Ser 
    50                  55                  60                  


Lys Lys Val Lys Asn Met 
65                  70  


<210>  20
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Thr Ser Tyr Leu Leu Leu Phe Thr Leu Cys Leu Leu Leu Ser 
1               5                   10                  15      


Glu Met Ala Ser Gly Gly Asn Phe Leu Thr Gly Leu Gly His Arg Ser 
            20                  25                  30          


Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
        35                  40                  45              


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
    50                  55                  60                  


Lys Cys Cys Lys 
65              


<210>  21
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Arg Val Leu Tyr Leu Leu Phe Ser Phe Leu Phe Ile Phe Leu Met 
1               5                   10                  15      


Pro Leu Pro Gly Val Phe Gly Gly Ile Gly Asp Pro Val Thr Cys Leu 
            20                  25                  30          


Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys Pro Arg Arg Tyr Lys 
        35                  40                  45              


Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys Cys Cys Lys Lys Pro 
    50                  55                  60                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  peptide inhibitor of CCR6

<400>  22

Glu Leu Cys Cys Leu Val Tyr Thr Ser Trp Gln Ile Pro Gln Lys Phe 
1               5                   10                  15      


Ile Val Asp Tyr Ser Glu Thr Ser Pro Gln Cys Pro Lys 
            20                  25                  


<210>  23
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  peptide inhibitor of CCR6

<400>  23

Phe Asp Cys Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe 
1               5                   10                  15      


Ile Val Gly Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile 
            20                  25                  30      


<210>  24
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  polynucleotide sequence encoding peptide according to SEQ ID NO.:
       9

<400>  24
gaggactgct gcctcgtcta tacctcctgg cagattcacc caaagttcat agttgactat     60

tctgaaacca gcccccagtg ccccaag                                         87


<210>  25
<211>  87
<212>  DNA
<213>  Artificial

<220>
<223>  polynucleotide sequence encoding polypeptide according to SEQ ID 
       NO.:22

<400>  25
gagctctgct gcctcgtcta tacctcctgg cagattccac aaaagttcat agttgactat     60

tctgaaacca gcccccagtg ccccaag                                         87


<210>  26
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  polynucleotide sequence encoding polypeptide according to SEQ ID 
       NO.:23

<400>  26
tttgactgct gtcttggata cacagaccgt attcttcatc ctaaatttat tgtgggcttc     60

acacggcagc tggccaatga aggctgtgac atc                                  93


<210>  27
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Gly Glu Ser Met Asn Phe Ser Asp Val Phe Asp Ser Ser Glu 
1               5                   10                  15      


Asp Tyr Phe Val Ser Val Asn Thr Ser Tyr Tyr Ser Val Asp Ser Glu 
            20                  25                  30          


Met Leu Leu Cys Ser Leu Gln Glu Val Arg Gln Phe Ser Arg Leu Phe 
        35                  40                  45              


Val Pro Ile Ala Tyr Ser Leu Ile Cys Val Phe Gly Leu Leu Gly Asn 
    50                  55                  60                  


Ile Leu Val Val Ile Thr Phe Ala Phe Tyr Lys Lys Ala Arg Ser Met 
65                  70                  75                  80  


Thr Asp Val Tyr Leu Leu Asn Met Ala Ile Ala Asp Ile Leu Phe Val 
                85                  90                  95      


Leu Thr Leu Pro Phe Trp Ala Val Ser His Ala Thr Gly Ala Trp Val 
            100                 105                 110         


Phe Ser Asn Ala Thr Cys Lys Leu Leu Lys Gly Ile Tyr Ala Ile Asn 
        115                 120                 125             


Phe Asn Cys Gly Met Leu Leu Leu Thr Cys Ile Ser Met Asp Arg Tyr 
    130                 135                 140                 


Ile Ala Ile Val Gln Ala Thr Lys Ser Phe Arg Leu Arg Ser Arg Thr 
145                 150                 155                 160 


Leu Pro Arg Ser Lys Ile Ile Cys Leu Val Val Trp Gly Leu Ser Val 
                165                 170                 175     


Ile Ile Ser Ser Ser Thr Phe Val Phe Asn Gln Lys Tyr Asn Thr Gln 
            180                 185                 190         


Gly Ser Asp Val Cys Glu Pro Lys Tyr Gln Thr Val Ser Glu Pro Ile 
        195                 200                 205             


Arg Trp Lys Leu Leu Met Leu Gly Leu Glu Leu Leu Phe Gly Phe Phe 
    210                 215                 220                 


Ile Pro Leu Met Phe Met Ile Phe Cys Tyr Thr Phe Ile Val Lys Thr 
225                 230                 235                 240 


Leu Val Gln Ala Gln Asn Ser Lys Arg His Lys Ala Ile Arg Val Ile 
                245                 250                 255     


Ile Ala Val Val Leu Val Phe Leu Ala Cys Gln Ile Pro His Asn Met 
            260                 265                 270         


Val Leu Leu Val Thr Ala Ala Asn Leu Gly Lys Met Asn Arg Ser Cys 
        275                 280                 285             


Gln Ser Glu Lys Leu Ile Gly Tyr Thr Lys Thr Val Thr Glu Val Leu 
    290                 295                 300                 


Ala Phe Leu His Cys Cys Leu Asn Pro Val Leu Tyr Ala Phe Ile Gly 
305                 310                 315                 320 


Gln Lys Phe Arg Asn Tyr Phe Leu Lys Ile Leu Lys Asp Leu Trp Cys 
                325                 330                 335     


Val Arg Arg Lys Tyr Lys Ser Ser Gly Phe Ser Cys Ala Gly Arg Tyr 
            340                 345                 350         


Ser Glu Asn Ile Ser Arg Gln Thr Ser Glu Thr Ala Asp Asn Asp Asn 
        355                 360                 365             


Ala Ser Ser Phe Thr Met 
    370                 


