                         SEQUENCE LISTING

<110>  Brandeis University
 
<120>  CANCER THERAPY

<130>  2004952-0018

<140>  PCT/US11/41682
<141>  2011-06-23

<150>  US 61/357,845
<151>  2010-06-23

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RAS family hypervariable region CAAX motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa= an aliphatic amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa= Ser or Thr

<400>  1

Cys Xaa Xaa Xaa 
1               


<210>  2
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Tyr Lys Met Asn Ile Cys Asn Lys Pro Ser Asn Lys Thr Ala Pro 
1               5                   10                  15      


Glu Lys Ser Val Trp Thr Ala Pro Ala Gln Pro Ser Gly Pro Ser Pro 
            20                  25                  30          


Glu Leu Gln Gly Gln Arg Ser Arg Arg Asn Gly Trp Ser Trp Pro Pro 
        35                  40                  45              


His Pro Leu Gln Ile Val Ala Trp Leu Leu Tyr Leu Phe Phe Ala Val 
    50                  55                  60                  


Ile Gly Phe Gly Ile Leu Val Pro Leu Leu Pro His His Trp Val Pro 
65                  70                  75                  80  


Ala Gly Tyr Ala Cys Met Gly Ala Ile Phe Ala Gly His Leu Val Val 
                85                  90                  95      


His Leu Thr Ala Val Ser Ile Asp Pro Ala Asp Ala Asn Val Arg Asp 
            100                 105                 110         


Lys Ser Tyr Ala Gly Pro Leu Pro Ile Phe Asn Arg Ser Gln His Ala 
        115                 120                 125             


His Val Ile Glu Asp Leu His Cys Asn Leu Cys Asn Val Asp Val Ser 
    130                 135                 140                 


Ala Arg Ser Lys His Cys Ser Ala Cys Asn Lys Cys Val Cys Gly Phe 
145                 150                 155                 160 


Asp His His Cys Lys Trp Leu Asn Asn Cys Val Gly Glu Arg Asn Tyr 
                165                 170                 175     


Arg Leu Phe Leu His Ser Val Ala Ser Ala Leu Leu Gly Val Leu Leu 
            180                 185                 190         


Leu Val Leu Val Ala Thr Tyr Val Phe Val Glu Phe Phe Val Asn Pro 
        195                 200                 205             


Met Arg Leu Arg Thr Asn Arg His Phe Glu Val Leu Lys Asn His Thr 
    210                 215                 220                 


Asp Val Trp Phe Val Phe Leu Pro Ala Ala Pro Val Glu Thr Gln Ala 
225                 230                 235                 240 


Pro Ala Ile Leu Ala Leu Ala Ala Leu Leu Ile Leu Leu Gly Leu Leu 
                245                 250                 255     


Ser Thr Ala Leu Leu Gly His Leu Leu Cys Phe His Ile Tyr Leu Met 
            260                 265                 270         


Trp His Lys Leu Thr Thr Tyr Glu Tyr Ile Val Gln His Arg Pro Pro 
        275                 280                 285             


Gln Glu Ala Lys Gly Val His Arg Glu Leu Glu Ser Cys Pro Pro Lys 
    290                 295                 300                 


Met Arg Pro Ile Gln Glu Met Glu Phe Tyr Met Arg Thr Phe Arg His 
305                 310                 315                 320 


Met Arg Pro Glu Pro Pro Gly Gln Ala Gly Pro Ala Ala Val Asn Ala 
                325                 330                 335     


Lys His Ser Arg Pro Ala Ser Pro Asp Pro Thr Pro Gly Arg Arg Asp 
            340                 345                 350         


Cys Ala Gly Pro Pro Val Gln Val Glu Trp Asp Arg Lys Lys Pro Leu 
        355                 360                 365             


Pro Trp Arg Ser Pro Leu Leu Leu Leu Ala Met Trp Gly Pro Gln Ala 
    370                 375                 380                 


Pro Pro Cys Leu Cys Arg Lys Arg Gly Arg Gly Ala Cys Ile Lys Cys 
385                 390                 395                 400 


Glu Arg Leu Arg Pro Arg Ile Arg Arg Arg Gly Leu Gly Pro Pro Ala 
                405                 410                 415     


Ala Ala Pro Ala Arg Arg Arg Ile Pro Arg Thr Pro Ala Leu Cys Thr 
            420                 425                 430         


Pro Leu Ala Leu Pro Ala Pro Thr Thr Arg Arg Arg Gln Ser Pro Trp 
        435                 440                 445             


Thr Arg Phe Gln Trp Arg Arg Arg Ala Trp Ala Ala Pro Leu Trp Pro 
    450                 455                 460                 


Pro Arg Gly Ala Gly Ala Asp Ser Pro Arg Trp Arg Gly Arg Arg Val 
465                 470                 475                 480 


Arg Pro Pro Phe Ser 
                485 


<210>  3
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Pro Ser Gly Pro Gly Ser Ser Ala Arg Arg Arg Cys Arg Arg 
1               5                   10                  15      


Val Leu Tyr Trp Ile Pro Val Val Phe Ile Thr Leu Leu Leu Gly Trp 
            20                  25                  30          


Ser Tyr Tyr Ala Tyr Ala Ile Gln Leu Cys Ile Val Ser Met Glu Asn 
        35                  40                  45              


Thr Gly Glu Gln Val Val Cys Leu Met Ala Tyr His Leu Leu Phe Ala 
    50                  55                  60                  


Met Phe Val Trp Ser Tyr Trp Lys Thr Ile Phe Thr Leu Pro Met Asn 
65                  70                  75                  80  


Pro Ser Lys Glu Phe His Leu Ser Tyr Ala Glu Lys Asp Leu Leu Glu 
                85                  90                  95      


Arg Glu Pro Arg Gly Glu Ala His Gln Glu Val Leu Arg Arg Ala Ala 
            100                 105                 110         


Lys Asp Leu Pro Ile Tyr Thr Arg Thr Met Ser Gly Ala Ile Arg Tyr 
        115                 120                 125             


Cys Asp Arg Cys Gln Leu Ile Lys Pro Asp Arg Cys His His Cys Ser 
    130                 135                 140                 


Val Cys Asp Lys Cys Ile Leu Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Phe Ser Asn Tyr Lys Phe Phe Leu Leu Phe Leu 
                165                 170                 175     


Ala Tyr Ser Leu Leu Tyr Cys Leu Phe Ile Ala Ala Thr Asp Leu Gln 
            180                 185                 190         


Tyr Phe Ile Lys Phe Trp Thr Asn Gly Leu Pro Asp Thr Gln Ala Lys 
        195                 200                 205             


Phe His Ile Met Phe Leu Phe Phe Ala Ala Ala Met Phe Ser Val Ser 
    210                 215                 220                 


Leu Ser Ser Leu Phe Gly Tyr His Cys Trp Leu Val Ser Lys Asn Lys 
225                 230                 235                 240 


Ser Thr Leu Glu Ala Phe Arg Ser Pro Val Phe Arg His Gly Thr Asp 
                245                 250                 255     


Lys Asn Gly Phe Ser Leu Gly Phe Ser Lys Asn Met Arg Gln Val Phe 
            260                 265                 270         


Gly Asp Glu Lys Lys Tyr Trp Leu Leu Pro Ile Phe Ser Ser Leu Gly 
        275                 280                 285             


Asp Gly Cys Ser Phe Pro Thr Cys Leu Val Asn Gln Asp Pro Glu Gln 
    290                 295                 300                 


Ala Ser Thr Pro Ala Gly Leu Asn Ser Thr Ala Lys Asn Leu Glu Asn 
305                 310                 315                 320 


His Gln Phe Pro Ala Lys Pro Leu Arg Glu Ser Gln Ser His Leu Leu 
                325                 330                 335     


Thr Asp Ser Gln Ser Trp Thr Glu Ser Ser Ile Asn Pro Gly Lys Cys 
            340                 345                 350         


Lys Ala Gly Met Ser Asn Pro Ala Leu Thr Met Glu Asn Glu Thr 
        355                 360                 365         


<210>  4
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Lys Cys Ser Ser Phe 
        195                 200                 205             


Ser Pro Pro Thr Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly 
    210                 215                 220                 


Leu Leu Phe Leu Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His 
225                 230                 235                 240 


Ser Ile Cys Thr Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu 
                245                 250                 255     


Arg Arg Trp Ala Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe 
            260                 265                 270         


Gly His Pro Phe Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp 
        275                 280                 285             


Gln Gly Lys Ala Asp Pro Tyr Gln Tyr Val Val 
    290                 295                 


<210>  5
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asp Phe Leu Val Leu Phe Leu Phe Tyr Leu Ala Ser Val Leu Met 
1               5                   10                  15      


Gly Leu Val Leu Ile Cys Val Cys Ser Lys Thr His Ser Leu Lys Gly 
            20                  25                  30          


Leu Ala Arg Gly Gly Ala Gln Ile Phe Ser Cys Ile Ile Pro Glu Cys 
        35                  40                  45              


Leu Gln Arg Ala Val His Gly Leu Leu His Tyr Leu Phe His Thr Arg 
    50                  55                  60                  


Asn His Thr Phe Ile Val Leu His Leu Val Leu Gln Gly Met Val Tyr 
65                  70                  75                  80  


Thr Glu Tyr Thr Trp Glu Val Phe Gly Tyr Cys Gln Glu Leu Glu Leu 
                85                  90                  95      


Ser Leu His Tyr Leu Leu Leu Pro Tyr Leu Leu Leu Gly Val Asn Leu 
            100                 105                 110         


Phe Phe Phe Thr Leu Thr Cys Gly Thr Asn Pro Gly Ile Ile Thr Lys 
        115                 120                 125             


Ala Asn Glu Leu Leu Phe Leu His Val Tyr Glu Phe Asp Glu Val Met 
    130                 135                 140                 


Phe Pro Lys Asn Val Arg Cys Ser Thr Cys Asp Leu Arg Lys Pro Ala 
145                 150                 155                 160 


Arg Ser Lys His Cys Ser Val Cys Asn Trp Cys Val His Arg Phe Asp 
                165                 170                 175     


His His Cys Val Trp Val Asn Asn Cys Ile Gly Ala Trp Asn Ile Arg 
            180                 185                 190         


Tyr Phe Leu Ile Tyr Val Leu Thr Leu Thr Ala Ser Ala Ala Thr Val 
        195                 200                 205             


Ala Ile Val Ser Thr Thr Phe Leu Val His Leu Val Val Met Ser Asp 
    210                 215                 220                 


Leu Tyr Gln Glu Thr Tyr Ile Asp Asp Leu Gly His Leu His Val Met 
225                 230                 235                 240 


Asp Thr Val Phe Leu Ile Gln Tyr Leu Phe Leu Thr Phe Pro Arg Ile 
                245                 250                 255     


Val Phe Met Leu Gly Phe Val Val Val Leu Ser Phe Leu Leu Gly Gly 
            260                 265                 270         


Tyr Leu Leu Phe Val Leu Tyr Leu Ala Ala Thr Asn Gln Thr Thr Asn 
        275                 280                 285             


Glu Trp Tyr Arg Gly Asp Trp Ala Trp Cys Gln Arg Cys Pro Leu Val 
    290                 295                 300                 


Ala Trp Pro Pro Ser Ala Glu Pro Gln Val His Arg Asn Ile His Ser 
305                 310                 315                 320 


His Gly Leu Arg Ser Asn Leu Gln Glu Ile Phe Leu Pro Ala Phe Pro 
                325                 330                 335     


Cys His Glu Arg Lys Lys Gln Glu 
            340                 


<210>  6
<211>  715
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ala Glu Ser Gly Lys Arg Phe Lys Pro Ser Lys Tyr Val Pro 
1               5                   10                  15      


Val Ser Ala Ala Ala Ile Phe Leu Val Gly Ala Thr Thr Leu Phe Phe 
            20                  25                  30          


Ala Phe Thr Cys Pro Gly Leu Ser Leu Tyr Val Ser Pro Ala Val Pro 
        35                  40                  45              


Ile Tyr Asn Ala Ile Met Phe Leu Phe Val Leu Ala Asn Phe Ser Met 
    50                  55                  60                  


Ala Thr Phe Met Asp Pro Gly Ile Phe Pro Arg Ala Glu Glu Asp Glu 
65                  70                  75                  80  


Asp Lys Glu Asp Asp Phe Arg Ala Pro Leu Tyr Lys Thr Val Glu Ile 
                85                  90                  95      


Lys Gly Ile Gln Val Arg Met Lys Trp Cys Ala Thr Cys Arg Phe Tyr 
            100                 105                 110         


Arg Pro Pro Arg Cys Ser His Cys Ser Val Cys Asp Asn Cys Val Glu 
        115                 120                 125             


Glu Phe Asp His His Cys Pro Trp Val Asn Asn Cys Ile Gly Arg Arg 
    130                 135                 140                 


Asn Tyr Arg Tyr Phe Phe Leu Phe Leu Leu Ser Leu Thr Ala His Ile 
145                 150                 155                 160 


Met Gly Val Phe Gly Phe Gly Leu Leu Tyr Val Leu Tyr His Ile Glu 
                165                 170                 175     


Glu Leu Ser Gly Val Arg Thr Ala Val Thr Met Ala Val Met Cys Val 
            180                 185                 190         


Ala Gly Leu Phe Phe Ile Pro Val Ala Gly Leu Thr Gly Phe His Val 
        195                 200                 205             


Val Leu Val Ala Arg Gly Arg Thr Thr Asn Glu Gln Val Thr Gly Lys 
    210                 215                 220                 


Phe Arg Gly Gly Val Asn Pro Phe Thr Asn Gly Cys Cys Asn Asn Val 
225                 230                 235                 240 


Ser Arg Val Leu Cys Ser Ser Pro Ala Pro Arg Tyr Leu Gly Arg Pro 
                245                 250                 255     


Lys Lys Glu Lys Thr Ile Val Ile Arg Pro Pro Phe Leu Arg Pro Glu 
            260                 265                 270         


Val Ser Asp Gly Gln Ile Thr Val Lys Ile Met Asp Asn Gly Ile Gln 
        275                 280                 285             


Gly Glu Leu Arg Arg Thr Lys Ser Lys Gly Ser Leu Glu Ile Thr Glu 
    290                 295                 300                 


Ser Gln Ser Ala Asp Ala Glu Pro Pro Pro Pro Pro Lys Pro Asp Leu 
305                 310                 315                 320 


Ser Arg Tyr Thr Gly Leu Arg Thr His Leu Gly Leu Ala Thr Asn Glu 
                325                 330                 335     


Asp Ser Ser Leu Leu Ala Lys Asp Ser Pro Pro Thr Pro Thr Met Tyr 
            340                 345                 350         


Lys Tyr Arg Pro Gly Tyr Ser Ser Ser Ser Thr Ser Ala Ala Met Pro 
        355                 360                 365             


His Ser Ser Ser Ala Lys Leu Ser Arg Gly Asp Ser Leu Lys Glu Pro 
    370                 375                 380                 


Thr Ser Ile Ala Glu Ser Ser Arg His Pro Ser Tyr Arg Ser Glu Pro 
385                 390                 395                 400 


Ser Leu Glu Pro Glu Ser Phe Arg Ser Pro Thr Phe Gly Lys Ser Phe 
                405                 410                 415     


His Phe Asp Pro Leu Ser Ser Gly Ser Arg Ser Ser Ser Leu Lys Ser 
            420                 425                 430         


Ala Gln Gly Thr Gly Phe Glu Leu Gly Gln Leu Gln Ser Ile Arg Ser 
        435                 440                 445             


Glu Gly Thr Thr Ser Thr Ser Tyr Lys Ser Leu Ala Asn Gln Thr Arg 
    450                 455                 460                 


Asn Gly Ser Leu Ser Tyr Asp Ser Leu Leu Thr Pro Ser Asp Ser Pro 
465                 470                 475                 480 


Asp Phe Glu Ser Val Gln Ala Gly Pro Glu Pro Asp Pro Pro Leu Gly 
                485                 490                 495     


Tyr Thr Ser Pro Phe Leu Ser Ala Arg Leu Ala Gln Gln Arg Glu Ala 
            500                 505                 510         


Glu Arg His Pro Arg Leu Val Pro Thr Gly Pro Thr His Arg Glu Pro 
        515                 520                 525             


Ser Pro Val Arg Tyr Asp Asn Leu Ser Arg His Ile Val Ala Ser Leu 
    530                 535                 540                 


Gln Glu Arg Glu Lys Leu Leu Arg Gln Ser Pro Pro Leu Pro Gly Arg 
545                 550                 555                 560 


Glu Glu Glu Pro Gly Leu Gly Asp Ser Gly Ile Gln Ser Thr Pro Gly 
                565                 570                 575     


Ser Gly His Ala Pro Arg Thr Ser Ser Ser Ser Asp Asp Ser Lys Arg 
            580                 585                 590         


Ser Pro Leu Gly Lys Thr Pro Leu Gly Arg Pro Ala Val Pro Arg Phe 
        595                 600                 605             


Gly Lys Pro Asp Gly Leu Arg Gly Arg Gly Val Gly Ser Pro Glu Pro 
    610                 615                 620                 


Gly Pro Thr Ala Pro Tyr Leu Gly Arg Ser Met Ser Tyr Ser Ser Gln 
625                 630                 635                 640 


Lys Ala Gln Pro Gly Val Ser Glu Thr Glu Glu Val Ala Leu Gln Pro 
                645                 650                 655     


Leu Leu Thr Pro Lys Asp Glu Val Gln Leu Lys Thr Thr Tyr Ser Lys 
            660                 665                 670         


Ser Asn Gly Gln Pro Lys Ser Leu Gly Ser Ala Ser Pro Gly Pro Gly 
        675                 680                 685             


Gln Pro Pro Leu Ser Ser Pro Thr Arg Gly Gly Val Lys Lys Val Ser 
    690                 695                 700                 


Gly Val Gly Gly Thr Thr Tyr Glu Ile Ser Val 
705                 710                 715 


<210>  7
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Thr Phe Cys Ser Val Ile Lys Phe Glu Asn Leu Gln Glu Leu 
1               5                   10                  15      


Lys Arg Leu Cys His Trp Gly Pro Ile Ile Ala Leu Gly Val Ile Ala 
            20                  25                  30          


Ile Cys Ser Thr Met Ala Met Ile Asp Ser Val Leu Trp Tyr Trp Pro 
        35                  40                  45              


Leu His Thr Thr Gly Gly Ser Val Asn Phe Ile Met Leu Ile Asn Trp 
    50                  55                  60                  


Thr Val Met Ile Leu Tyr Asn Tyr Phe Asn Ala Met Phe Val Gly Pro 
65                  70                  75                  80  


Gly Phe Val Pro Leu Gly Trp Lys Pro Glu Ile Ser Gln Asp Thr Met 
                85                  90                  95      


Tyr Leu Gln Tyr Cys Lys Val Cys Gln Ala Tyr Lys Ala Pro Arg Ser 
            100                 105                 110         


His His Cys Arg Lys Cys Asn Arg Cys Val Met Lys Met Asp His His 
        115                 120                 125             


Cys Pro Trp Ile Asn Asn Cys Cys Gly Tyr Gln Asn His Ala Ser Phe 
    130                 135                 140                 


Thr Leu Phe Leu Leu Leu Ala Pro Leu Gly Cys Ile His Ala Ala Phe 
145                 150                 155                 160 


Ile Phe Val Met Thr Met Tyr Thr Gln Leu Tyr His Arg Leu Ser Phe 
                165                 170                 175     


Gly Trp Asn Thr Val Lys Ile Asp Met Ser Ala Ala Arg Arg Asp Pro 
            180                 185                 190         


Leu Pro Ile Val Pro Phe Gly Leu Ala Ala Phe Ala Thr Thr Leu Phe 
        195                 200                 205             


Ala Leu Gly Leu Ala Leu Gly Thr Thr Ile Ala Val Gly Met Leu Phe 
    210                 215                 220                 


Phe Ile Gln Met Lys Ile Ile Leu Arg Asn Lys Thr Ser Ile Glu Ser 
225                 230                 235                 240 


Trp Ile Glu Glu Lys Ala Lys Asp Arg Ile Gln Tyr Tyr Gln Leu Asp 
                245                 250                 255     


Glu Val Phe Val Phe Pro Tyr Asp Met Gly Ser Arg Trp Arg Asn Phe 
            260                 265                 270         


Lys Gln Val Phe Thr Trp Ser Gly Val Pro Glu Gly Asp Gly Leu Glu 
        275                 280                 285             


Trp Pro Val Arg Glu Gly Cys His Gln Tyr Ser Leu Thr Ile Glu Gln 
    290                 295                 300                 


Leu Lys Gln Lys Ala Asp Lys Arg Val Arg Ser Val Arg Tyr Lys Val 
305                 310                 315                 320 


Ile Glu Asp Tyr Ser Gly Ala Cys Cys Pro Leu Asn Lys Gly Ile Lys 
                325                 330                 335     


Thr Phe Phe Thr Ser Pro Cys Thr Glu Glu Pro Arg Ile Gln Leu Gln 
            340                 345                 350         


Lys Gly Glu Phe Ile Leu Ala Thr Arg Gly Leu Arg Tyr Trp Leu Tyr 
        355                 360                 365             


Gly Asp Lys Ile Leu Asp Asp Ser Phe Ile Glu Gly Val Ser Arg Ile 
    370                 375                 380                 


Arg Gly Trp Phe Pro Arg Lys Cys Val Glu Lys Cys Pro Cys Asp Ala 
385                 390                 395                 400 


Glu Thr Asp Gln Ala Pro Glu Gly Glu Lys Lys Asn Arg 
                405                 410             


<210>  8
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Pro Ser Gly His Arg Leu Arg Asp Val Glu His His Pro Leu 
1               5                   10                  15      


Leu Ala Glu Asn Asp Asn Tyr Asp Ser Ser Ser Ser Ser Ser Ser Glu 
            20                  25                  30          


Ala Asp Val Ala Asp Arg Val Trp Phe Ile Arg Asp Gly Cys Gly Met 
        35                  40                  45              


Ile Cys Ala Val Met Thr Trp Leu Leu Val Ala Tyr Ala Asp Phe Val 
    50                  55                  60                  


Val Thr Phe Val Met Leu Leu Pro Ser Lys Asp Phe Trp Tyr Ser Val 
65                  70                  75                  80  


Val Asn Gly Val Ile Phe Asn Cys Leu Ala Val Leu Ala Leu Ser Ser 
                85                  90                  95      


His Leu Arg Thr Met Leu Thr Asp Pro Glu Lys Ser Ser Asp Cys Arg 
            100                 105                 110         


Pro Ser Ala Cys Thr Val Lys Thr Gly Leu Asp Pro Thr Leu Val Gly 
        115                 120                 125             


Ile Cys Gly Glu Gly Thr Glu Ser Val Gln Ser Leu Leu Leu Gly Ala 
    130                 135                 140                 


Val Pro Lys Gly Asn Ala Thr Lys Glu Tyr Met Glu Ser Leu Gln Leu 
145                 150                 155                 160 


Lys Pro Gly Glu Val Ile Tyr Lys Cys Pro Lys Cys Cys Cys Ile Lys 
                165                 170                 175     


Pro Glu Arg Ala His His Cys Ser Ile Cys Lys Arg Cys Ile Arg Lys 
            180                 185                 190         


Met Asp His His Cys Pro Trp Val Asn Asn Cys Val Gly Glu Lys Asn 
        195                 200                 205             


Gln Arg Phe Phe Val Leu Phe Thr Met Tyr Ile Ala Leu Ser Ser Val 
    210                 215                 220                 


His Ala Leu Ile Leu Cys Gly Phe Gln Phe Ile Ser Cys Val Arg Gly 
225                 230                 235                 240 


Gln Trp Thr Glu Cys Ser Asp Phe Ser Pro Pro Ile Thr Val Ile Leu 
                245                 250                 255     


Leu Ile Phe Leu Cys Leu Glu Gly Leu Leu Phe Phe Thr Phe Thr Ala 
            260                 265                 270         


Val Met Phe Gly Thr Gln Ile His Ser Ile Cys Asn Asp Glu Thr Glu 
        275                 280                 285             


Ile Glu Arg Leu Lys Ser Glu Lys Pro Thr Trp Glu Arg Arg Leu Arg 
    290                 295                 300                 


Trp Glu Gly Met Lys Ser Val Phe Gly Gly Pro Pro Ser Leu Leu Trp 
305                 310                 315                 320 


Met Asn Pro Phe Val Gly Phe Arg Phe Arg Arg Leu Pro Thr Arg Pro 
                325                 330                 335     


Arg Lys Gly Gly Pro Glu Phe Ser Val 
            340                 345 


<210>  9
<211>  765
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Arg Ser Pro Gly Thr Arg Leu Lys Pro Ala Lys Tyr Ile Pro 
1               5                   10                  15      


Val Ala Thr Ala Ala Ala Leu Leu Val Gly Ser Ser Thr Leu Phe Phe 
            20                  25                  30          


Val Phe Thr Cys Pro Trp Leu Thr Arg Ala Val Ser Pro Ala Val Pro 
        35                  40                  45              


Val Tyr Asn Gly Ile Ile Phe Leu Phe Val Leu Ala Asn Phe Ser Met 
    50                  55                  60                  


Ala Thr Phe Met Asp Pro Gly Val Phe Pro Arg Ala Asp Glu Asp Glu 
65                  70                  75                  80  


Asp Lys Glu Asp Asp Phe Arg Ala Pro Leu Tyr Lys Asn Val Asp Val 
                85                  90                  95      


Arg Gly Ile Gln Val Arg Met Lys Trp Cys Ala Thr Cys His Phe Tyr 
            100                 105                 110         


Arg Pro Pro Arg Cys Ser His Cys Ser Val Cys Asp Asn Cys Val Glu 
        115                 120                 125             


Asp Phe Asp His His Cys Pro Trp Val Asn Asn Cys Ile Gly Arg Arg 
    130                 135                 140                 


Asn Tyr Arg Tyr Phe Phe Leu Phe Leu Leu Ser Leu Ser Ala His Met 
145                 150                 155                 160 


Val Gly Val Val Ala Phe Gly Leu Val Tyr Val Leu Asn His Ala Glu 
                165                 170                 175     


Gly Leu Gly Ala Ala His Thr Thr Ile Thr Met Ala Val Met Cys Val 
            180                 185                 190         


Ala Gly Leu Phe Phe Ile Pro Val Ile Gly Leu Thr Gly Phe His Val 
        195                 200                 205             


Val Leu Val Thr Arg Gly Arg Thr Thr Asn Glu Gln Val Thr Gly Lys 
    210                 215                 220                 


Phe Arg Gly Gly Val Asn Pro Phe Thr Arg Gly Cys Cys Gly Asn Val 
225                 230                 235                 240 


Glu His Val Leu Cys Ser Pro Leu Ala Pro Arg Tyr Val Val Glu Pro 
                245                 250                 255     


Pro Arg Leu Pro Leu Ala Val Ser Leu Lys Pro Pro Phe Leu Arg Pro 
            260                 265                 270         


Glu Leu Leu Asp Arg Ala Ala Pro Leu Lys Val Lys Leu Ser Asp Asn 
        275                 280                 285             


Gly Leu Lys Ala Gly Leu Gly Arg Ser Lys Ser Lys Gly Ser Leu Asp 
    290                 295                 300                 


Arg Leu Asp Glu Lys Pro Leu Asp Leu Gly Pro Pro Leu Pro Pro Lys 
305                 310                 315                 320 


Ile Glu Ala Gly Thr Phe Ser Ser Asp Leu Gln Thr Pro Arg Pro Gly 
                325                 330                 335     


Ser Ala Glu Ser Ala Leu Ser Val Gln Arg Thr Ser Pro Pro Thr Pro 
            340                 345                 350         


Ala Met Tyr Lys Phe Arg Pro Ala Phe Pro Thr Gly Pro Lys Val Pro 
        355                 360                 365             


Phe Cys Gly Pro Gly Glu Gln Val Pro Gly Pro Asp Ser Leu Thr Leu 
    370                 375                 380                 


Gly Asp Asp Ser Ile Arg Ser Leu Asp Phe Val Ser Glu Pro Ser Leu 
385                 390                 395                 400 


Asp Leu Pro Asp Tyr Gly Pro Gly Gly Leu His Ala Ala Tyr Pro Pro 
                405                 410                 415     


Ser Pro Pro Leu Ser Ala Ser Asp Ala Phe Ser Gly Ala Leu Arg Ser 
            420                 425                 430         


Leu Ser Leu Lys Ala Ser Ser Arg Arg Gly Gly Asp His Val Ala Leu 
        435                 440                 445             


Gln Pro Leu Arg Ser Glu Gly Gly Pro Pro Thr Pro His Arg Ser Ile 
    450                 455                 460                 


Phe Ala Pro His Ala Leu Pro Asn Arg Asn Gly Ser Leu Ser Tyr Asp 
465                 470                 475                 480 


Ser Leu Leu Asn Pro Gly Ser Pro Gly Gly His Ala Cys Pro Ala His 
                485                 490                 495     


Pro Ala Val Gly Val Ala Gly Tyr His Ser Pro Tyr Leu His Pro Gly 
            500                 505                 510         


Ala Thr Gly Asp Pro Pro Arg Pro Leu Pro Arg Ser Phe Ser Pro Val 
        515                 520                 525             


Leu Gly Pro Arg Pro Arg Glu Pro Ser Pro Val Arg Tyr Asp Asn Leu 
    530                 535                 540                 


Ser Arg Thr Ile Met Ala Ser Ile Gln Glu Arg Lys Asp Arg Glu Glu 
545                 550                 555                 560 


Arg Glu Arg Leu Leu Arg Ser Gln Ala Asp Ser Leu Phe Gly Asp Ser 
                565                 570                 575     


Gly Val Tyr Asp Ala Pro Ser Ser Tyr Ser Leu Gln Gln Ala Ser Val 
            580                 585                 590         


Leu Ser Glu Gly Pro Arg Gly Pro Ala Leu Arg Tyr Gly Ser Arg Asp 
        595                 600                 605             


Asp Leu Val Ala Gly Pro Gly Phe Gly Gly Ala Arg Asn Pro Ala Leu 
    610                 615                 620                 


Gln Thr Ser Leu Ser Ser Leu Ser Ser Ser Val Ser Arg Ala Pro Arg 
625                 630                 635                 640 


Thr Ser Ser Ser Ser Leu Gln Ala Asp Gln Ala Ser Ser Asn Ala Pro 
                645                 650                 655     


Gly Pro Arg Pro Ser Ser Gly Ser His Arg Ser Pro Ala Arg Gln Gly 
            660                 665                 670         


Leu Pro Ser Pro Pro Gly Thr Pro His Ser Pro Ser Tyr Ala Gly Pro 
        675                 680                 685             


Lys Ala Val Ala Phe Ile His Thr Asp Leu Pro Glu Pro Pro Pro Ser 
    690                 695                 700                 


Leu Thr Val Gln Arg Asp His Pro Gln Leu Lys Thr Pro Pro Ser Lys 
705                 710                 715                 720 


Leu Asn Gly Gln Ser Pro Gly Leu Ala Arg Leu Gly Pro Ala Thr Gly 
                725                 730                 735     


Pro Pro Gly Pro Ser Ala Ser Pro Thr Arg His Thr Leu Val Lys Lys 
            740                 745                 750         


Val Ser Gly Val Gly Gly Thr Thr Tyr Glu Ile Ser Val 
        755                 760                 765 


<210>  10
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Val Met Val Val Arg Lys Lys Val Thr Arg Lys Trp Glu Lys 
1               5                   10                  15      


Leu Pro Gly Arg Asn Thr Phe Cys Cys Asp Gly Arg Val Met Met Ala 
            20                  25                  30          


Arg Gln Lys Gly Ile Phe Tyr Leu Thr Leu Phe Leu Ile Leu Gly Thr 
        35                  40                  45              


Cys Thr Leu Phe Phe Ala Phe Glu Cys Arg Tyr Leu Ala Val Gln Leu 
    50                  55                  60                  


Ser Pro Ala Ile Pro Val Phe Ala Ala Met Leu Phe Leu Phe Ser Met 
65                  70                  75                  80  


Ala Thr Leu Leu Arg Thr Ser Phe Ser Asp Pro Gly Val Ile Pro Arg 
                85                  90                  95      


Ala Leu Pro Asp Glu Ala Ala Phe Ile Glu Met Glu Ile Glu Ala Thr 
            100                 105                 110         


Asn Gly Ala Val Pro Gln Gly Gln Arg Pro Pro Pro Arg Ile Lys Asn 
        115                 120                 125             


Phe Gln Ile Asn Asn Gln Ile Val Lys Leu Lys Tyr Cys Tyr Thr Cys 
    130                 135                 140                 


Lys Ile Phe Arg Pro Pro Arg Ala Ser His Cys Ser Ile Cys Asp Asn 
145                 150                 155                 160 


Cys Val Glu Arg Phe Asp His His Cys Pro Trp Val Gly Asn Cys Val 
                165                 170                 175     


Gly Lys Arg Asn Tyr Arg Tyr Phe Tyr Leu Phe Ile Leu Ser Leu Ser 
            180                 185                 190         


Leu Leu Thr Ile Tyr Val Phe Ala Phe Asn Ile Val Tyr Val Ala Leu 
        195                 200                 205             


Lys Ser Leu Lys Ile Gly Phe Leu Glu Thr Leu Lys Glu Thr Pro Gly 
    210                 215                 220                 


Thr Val Leu Glu Val Leu Ile Cys Phe Phe Thr Leu Trp Ser Val Val 
225                 230                 235                 240 


Gly Leu Thr Gly Phe His Thr Phe Leu Val Ala Leu Asn Gln Thr Thr 
                245                 250                 255     


Asn Glu Asp Ile Lys Gly Ser Trp Thr Gly Lys Asn Arg Val Gln Asn 
            260                 265                 270         


Pro Tyr Ser His Gly Asn Ile Val Lys Asn Cys Cys Glu Val Leu Cys 
        275                 280                 285             


Gly Pro Leu Pro Pro Ser Val Leu Asp Arg Arg Gly Ile Leu Pro Leu 
    290                 295                 300                 


Glu Glu Ser Gly Ser Arg Pro Pro Ser Thr Gln Glu Thr Ser Ser Ser 
305                 310                 315                 320 


Leu Leu Pro Gln Ser Pro Ala Pro Thr Glu His Leu Asn Ser Asn Glu 
                325                 330                 335     


Met Pro Glu Asp Ser Ser Thr Pro Glu Glu Met Pro Pro Pro Glu Pro 
            340                 345                 350         


Pro Glu Pro Pro Gln Glu Ala Ala Glu Ala Glu Lys 
        355                 360                 


<210>  11
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Thr Arg Ser Gly Ser Gln Cys Ser Val Thr Pro Glu Ala Ile 
1               5                   10                  15      


Leu Asn Asn Glu Lys Leu Val Leu Pro Pro Arg Ile Ser Arg Val Asn 
            20                  25                  30          


Gly Trp Ser Leu Pro Leu His Tyr Phe Gln Val Val Thr Trp Ala Val 
        35                  40                  45              


Phe Val Gly Leu Ser Ser Ala Thr Phe Gly Ile Phe Ile Pro Phe Leu 
    50                  55                  60                  


Pro His Ala Trp Lys Tyr Ile Ala Tyr Val Val Thr Gly Gly Ile Phe 
65                  70                  75                  80  


Ser Phe His Leu Val Val His Leu Ile Ala Ser Cys Ile Asp Pro Ala 
                85                  90                  95      


Asp Ser Asn Val Arg Leu Met Lys Asn Tyr Ser Gln Pro Met Pro Leu 
            100                 105                 110         


Phe Asp Arg Ser Lys His Ala His Val Ile Gln Asn Gln Phe Cys His 
        115                 120                 125             


Leu Cys Lys Val Thr Val Asn Lys Lys Thr Lys His Cys Ile Ser Cys 
    130                 135                 140                 


Asn Lys Cys Val Ser Gly Phe Asp His His Cys Lys Trp Ile Asn Asn 
145                 150                 155                 160 


Cys Val Gly Ser Arg Asn Tyr Trp Phe Phe Phe Ser Thr Val Ala Ser 
                165                 170                 175     


Ala Thr Ala Gly Met Leu Cys Leu Ile Ala Ile Leu Leu Tyr Val Leu 
            180                 185                 190         


Val Gln Tyr Leu Val Asn Pro Gly Val Leu Arg Thr Asp Pro Arg Tyr 
        195                 200                 205             


Glu Asp Val Lys Asn Met Asn Thr Trp Leu Leu Phe Leu Pro Leu Phe 
    210                 215                 220                 


Pro Val Gln Val Gln Thr Leu Ile Val Val Ile Ile Gly Met Leu Val 
225                 230                 235                 240 


Leu Leu Leu Asp Phe Leu Gly Leu Val His Leu Gly Gln Leu Leu Ile 
                245                 250                 255     


Phe His Ile Tyr Leu Lys Ala Lys Lys Met Thr Thr Phe Glu Tyr Leu 
            260                 265                 270         


Ile Asn Asn Arg Lys Glu Glu Ser Ser Lys His Gln Ala Val Arg Lys 
        275                 280                 285             


Asp Pro Tyr Val Gln Met Asp Lys Gly Val Leu Gln Gln Gly Ala Gly 
    290                 295                 300                 


Ala Leu Gly Ser Ser Ala Gln Gly Val Lys Ala Lys Ser Ser Leu Leu 
305                 310                 315                 320 


Ile His Lys His Leu Cys His Phe Cys Thr Ser Val Asn Gln Asp Gly 
                325                 330                 335     


Asp Ser Thr Ala Arg Glu Gly Asp Glu Asp Pro Cys Pro Ser Ala Leu 
            340                 345                 350         


Gly Ala Lys Ala Arg Asn Ser Arg Leu Ile Cys Arg Arg Leu Cys Gln 
        355                 360                 365             


Phe Ser Thr Arg Val His Pro Asp Gly Gly Ser Met Ala Gln Glu Ala 
    370                 375                 380                 


Asp Asp Ala Pro Ser Ile Ser Thr Leu Gly Leu Gln Gln Glu Thr Thr 
385                 390                 395                 400 


Glu Pro Met Lys Thr Asp Ser Ala Glu Ser Glu Asp 
                405                 410         


<210>  12
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Thr Arg Ser Gly Ser Gln Cys Ser Val Thr Pro Glu Ala Ile 
1               5                   10                  15      


Arg Asn Asn Glu Glu Leu Val Leu Pro Pro Arg Ile Ser Arg Val Asn 
            20                  25                  30          


Gly Trp Ser Leu Pro Leu His Tyr Phe Arg Val Val Thr Trp Ala Val 
        35                  40                  45              


Phe Val Gly Leu Ser Leu Ala Thr Phe Arg Ile Phe Ile Pro Leu Leu 
    50                  55                  60                  


Pro His Ser Trp Lys Tyr Ile Ala Tyr Val Val Thr Gly Gly Ile Phe 
65                  70                  75                  80  


Ser Phe His Leu Val Val His Leu Ile Ala Ser Cys Ile Asp Pro Ala 
                85                  90                  95      


Asp Ser Asn Val Arg Leu Met Lys Asn Tyr Ser Gln Pro Met Pro Leu 
            100                 105                 110         


Phe Asp Arg Ser Lys His Ala His Val Ile Gln Asn Gln Phe Cys His 
        115                 120                 125             


Leu Cys Lys Val Thr Val Asn Lys Lys Thr Lys His Cys Ile Ser Cys 
    130                 135                 140                 


Asn Lys Cys Val Ser Gly Phe Asp His His Cys Lys Trp Ile Asn Asn 
145                 150                 155                 160 


Cys Val Gly Ser Arg Asn Tyr Trp Phe Phe Phe Ser Thr Val Ala Ser 
                165                 170                 175     


Ala Thr Ala Gly Met Leu Cys Leu Ile Ala Ile Leu Leu Tyr Val Leu 
            180                 185                 190         


Val Gln Tyr Leu Val Asn Pro Arg Val Leu Arg Thr Asp Pro Arg Tyr 
        195                 200                 205             


Glu Asp Val Lys Asn Met Asn Thr Trp Leu Leu Phe Leu Pro Leu Phe 
    210                 215                 220                 


Pro Val Gln Val Gln Thr Leu Ile Val Val Ile Ile Arg Met Leu Val 
225                 230                 235                 240 


Leu Leu Leu Asp Leu Leu Gly Leu Val Gln Leu Gly Gln Leu Leu Ile 
                245                 250                 255     


Phe His Ile Tyr Leu Lys Ala Lys Lys Met Thr Thr Phe Glu Tyr Leu 
            260                 265                 270         


Ile Asn Thr Arg Lys Glu Glu Ser Ser Lys His Gln Ala Val Arg Lys 
        275                 280                 285             


Asp Pro Tyr Val Gln Met Asp Lys Gly Phe Leu Gln Gln Gly Ala Gly 
    290                 295                 300                 


Ala Leu Gly Ser Ser Ala Gln Gly Val Lys Ala Lys Ser Ser Leu Leu 
305                 310                 315                 320 


Ile Tyr Lys Cys Pro Cys His Phe Cys Thr Ser Val Asn Gln Asp Gly 
                325                 330                 335     


Asp Ser Lys Ala Gln Gly Arg Leu Thr Ala Leu Pro Gln Asp Phe Arg 
            340                 345                 350         


Glu Gln Ala Pro Val Thr Trp Lys 
        355                 360 


<210>  13
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Pro Trp Ala Leu Leu Ser Pro Gly Val Leu Val Arg Thr Gly 
1               5                   10                  15      


His Thr Val Leu Thr Trp Gly Ile Thr Leu Val Leu Phe Leu His Asp 
            20                  25                  30          


Thr Glu Leu Arg Gln Trp Glu Glu Gln Gly Glu Leu Leu Leu Pro Leu 
        35                  40                  45              


Thr Phe Leu Leu Leu Val Leu Gly Ser Leu Leu Leu Tyr Leu Ala Val 
    50                  55                  60                  


Ser Leu Met Asp Pro Gly Tyr Val Asn Val Gln Pro Gln Pro Gln Glu 
65                  70                  75                  80  


Glu Leu Lys Glu Glu Gln Thr Ala Met Val Pro Pro Ala Ile Pro Leu 
                85                  90                  95      


Arg Arg Cys Arg Tyr Cys Leu Val Leu Gln Pro Leu Arg Ala Arg His 
            100                 105                 110         


Cys Arg Glu Cys Arg Arg Cys Val Arg Arg Tyr Asp His His Cys Pro 
        115                 120                 125             


Trp Met Glu Asn Cys Val Gly Glu Arg Asn His Pro Leu Phe Val Val 
    130                 135                 140                 


Tyr Leu Ala Leu Gln Leu Val Val Leu Leu Trp Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Trp Ser Gly Leu Arg Phe Phe Gln Pro Trp Gly Leu Trp Leu Arg Ser 
                165                 170                 175     


Ser Gly Leu Leu Phe Ala Thr Phe Leu Leu Leu Ser Leu Phe Ser Leu 
            180                 185                 190         


Val Ala Ser Leu Leu Leu Val Ser His Leu Tyr Leu Val Ala Ser Asn 
        195                 200                 205             


Thr Thr Thr Trp Glu Phe Ile Ser Ser His Arg Ile Ala Tyr Leu Arg 
    210                 215                 220                 


Gln Arg Pro Ser Asn Pro Phe Asp Arg Gly Leu Thr Arg Asn Leu Ala 
225                 230                 235                 240 


His Phe Phe Cys Gly Trp Pro Ser Gly Ser Trp Glu Thr Leu Trp Ala 
                245                 250                 255     


Glu Glu Glu Glu Glu Gly Ser Ser Pro Ala Val 
            260                 265         


<210>  14
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Glu Gly Pro Gly Leu Gly Ser Gln Cys Arg Asn His Ser His Gly 
1               5                   10                  15      


Pro His Pro Pro Gly Phe Gly Arg Tyr Gly Ile Cys Ala His Glu Asn 
            20                  25                  30          


Lys Glu Leu Ala Asn Ala Arg Glu Ala Leu Pro Leu Ile Glu Asp Ser 
        35                  40                  45              


Ser Asn Cys Asp Ile Val Lys Ala Thr Gln Tyr Gly Ile Phe Glu Arg 
    50                  55                  60                  


Cys Lys Glu Leu Val Glu Ala Gly Tyr Asp Val Arg Gln Pro Asp Lys 
65                  70                  75                  80  


Glu Asn Val Ser Leu Leu His Trp Ala Ala Ile Asn Asn Arg Leu Asp 
                85                  90                  95      


Leu Val Lys Phe Tyr Ile Ser Lys Gly Ala Val Val Asp Gln Leu Gly 
            100                 105                 110         


Gly Asp Leu Asn Ser Thr Pro Leu His Trp Ala Ile Arg Gln Gly His 
        115                 120                 125             


Leu Pro Met Val Ile Leu Leu Leu Gln His Gly Ala Asp Pro Thr Leu 
    130                 135                 140                 


Ile Asp Gly Glu Gly Phe Ser Ser Ile His Leu Ala Val Leu Phe Gln 
145                 150                 155                 160 


His Met Pro Ile Ile Ala Tyr Leu Ile Ser Lys Gly Gln Ser Val Asn 
                165                 170                 175     


Met Thr Asp Val Asn Gly Gln Thr Pro Leu Met Leu Ser Ala His Lys 
            180                 185                 190         


Val Ile Gly Pro Glu Pro Thr Gly Phe Leu Leu Lys Phe Asn Pro Ser 
        195                 200                 205             


Leu Asn Val Val Asp Lys Ile His Gln Asn Thr Pro Leu His Trp Ala 
    210                 215                 220                 


Val Ala Ala Gly Asn Val Asn Ala Val Asp Lys Leu Leu Glu Ala Gly 
225                 230                 235                 240 


Ser Ser Leu Asp Ile Gln Asn Val Lys Gly Glu Thr Pro Leu Asp Met 
                245                 250                 255     


Ala Leu Gln Asn Lys Asn Gln Leu Ile Ile His Met Leu Lys Thr Glu 
            260                 265                 270         


Ala Lys Met Arg Ala Asn Gln Lys Phe Arg Leu Trp Arg Trp Leu Gln 
        275                 280                 285             


Lys Cys Glu Leu Phe Leu Leu Leu Met Leu Ser Val Ile Thr Met Trp 
    290                 295                 300                 


Ala Ile Gly Tyr Ile Leu Asp Phe Asn Ser Asp Ser Trp Leu Leu Lys 
305                 310                 315                 320 


Gly Cys Leu Leu Val Thr Leu Phe Phe Leu Thr Ser Leu Phe Pro Arg 
                325                 330                 335     


Phe Leu Val Gly Tyr Lys Asn Leu Val Tyr Leu Pro Thr Ala Phe Leu 
            340                 345                 350         


Leu Ser Ser Val Phe Trp Ile Phe Met Thr Trp Phe Ile Leu Phe Phe 
        355                 360                 365             


Pro Asp Leu Ala Gly Ala Pro Phe Tyr Phe Ser Phe Ile Phe Ser Ile 
    370                 375                 380                 


Val Ala Phe Leu Tyr Phe Phe Tyr Lys Thr Trp Ala Thr Asp Pro Gly 
385                 390                 395                 400 


Phe Thr Lys Ala Ser Glu Glu Glu Lys Lys Val Asn Ile Ile Thr Leu 
                405                 410                 415     


Ala Glu Thr Gly Ser Leu Asp Phe Arg Thr Phe Cys Thr Ser Cys Leu 
            420                 425                 430         


Ile Arg Lys Pro Leu Arg Ser Leu His Cys His Val Cys Asn Cys Cys 
        435                 440                 445             


Val Ala Arg Tyr Asp Gln His Cys Leu Trp Thr Gly Arg Cys Ile Gly 
    450                 455                 460                 


Phe Gly Asn His His Tyr Tyr Ile Phe Phe Leu Phe Phe Leu Ser Met 
465                 470                 475                 480 


Val Cys Gly Trp Ile Ile Tyr Gly Ser Phe Ile Tyr Leu Ser Ser His 
                485                 490                 495     


Cys Ala Thr Thr Phe Lys Glu Asp Gly Leu Trp Thr Tyr Leu Asn Gln 
            500                 505                 510         


Ile Val Ala Cys Ser Pro Trp Val Leu Tyr Ile Leu Met Leu Ala Thr 
        515                 520                 525             


Phe His Phe Ser Trp Ser Thr Phe Leu Leu Leu Asn Gln Leu Phe Gln 
    530                 535                 540                 


Ile Ala Phe Leu Gly Leu Thr Ser His Glu Arg Ile Ser Leu Gln Lys 
545                 550                 555                 560 


Gln Ser Lys His Met Lys Gln Thr Leu Ser Leu Arg Lys Thr Pro Tyr 
                565                 570                 575     


Asn Leu Gly Phe Met Gln Asn Leu Ala Asp Phe Phe Gln Cys Gly Cys 
            580                 585                 590         


Phe Gly Leu Val Lys Pro Cys Val Val Asp Trp Thr Ser Gln Tyr Thr 
        595                 600                 605             


Met Val Phe His Pro Ala Arg Glu Lys Val Leu Arg Ser Val 
    610                 615                 620         


<210>  15
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Pro Gly Gly Gly Gly Pro Met Lys Asp Cys Glu Tyr Ser Gln 
1               5                   10                  15      


Ile Ser Thr His Ser Ser Ser Pro Met Glu Ser Pro His Lys Lys Lys 
            20                  25                  30          


Lys Ile Ala Ala Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Lys 
        35                  40                  45              


Phe Phe Cys Asn Gly Arg Ile Met Met Ala Arg Gln Thr Gly Val Phe 
    50                  55                  60                  


Tyr Leu Thr Leu Val Leu Ile Leu Val Thr Ser Gly Leu Phe Phe Ala 
65                  70                  75                  80  


Phe Asp Cys Pro Tyr Leu Ala Val Lys Ile Thr Pro Ala Ile Pro Ala 
                85                  90                  95      


Val Ala Gly Ile Leu Phe Phe Phe Val Met Gly Thr Leu Leu Arg Thr 
            100                 105                 110         


Ser Phe Ser Asp Pro Gly Val Leu Pro Arg Ala Thr Pro Asp Glu Ala 
        115                 120                 125             


Ala Asp Leu Glu Arg Gln Ile Asp Ile Ala Asn Gly Thr Ser Ser Gly 
    130                 135                 140                 


Gly Tyr Arg Pro Pro Pro Arg Thr Lys Glu Val Ile Ile Asn Gly Gln 
145                 150                 155                 160 


Thr Val Lys Leu Lys Tyr Cys Phe Thr Cys Lys Ile Phe Arg Pro Pro 
                165                 170                 175     


Arg Ala Ser His Cys Ser Leu Cys Asp Asn Cys Val Glu Arg Phe Asp 
            180                 185                 190         


His His Cys Pro Trp Val Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg 
        195                 200                 205             


Phe Phe Tyr Met Phe Ile Leu Ser Leu Ser Phe Leu Thr Val Phe Ile 
    210                 215                 220                 


Phe Ala Phe Val Ile Thr His Val Ile Leu Arg Ser Gln Gln Thr Gly 
225                 230                 235                 240 


Phe Leu Asn Ala Leu Lys Asp Ser Pro Ala Ser Val Leu Glu Ala Val 
                245                 250                 255     


Val Cys Phe Phe Ser Val Trp Ser Ile Val Gly Leu Ser Gly Phe His 
            260                 265                 270         


Thr Tyr Leu Ile Ser Ser Asn Gln Thr Thr Asn Glu Asp Ile Lys Gly 
        275                 280                 285             


Ser Trp Ser Asn Lys Arg Gly Lys Glu Asn Tyr Asn Pro Tyr Ser Tyr 
    290                 295                 300                 


Gly Asn Ile Phe Thr Asn Cys Cys Val Ala Leu Cys Gly Pro Ile Ser 
305                 310                 315                 320 


Pro Ser Leu Ile Asp Arg Arg Gly Tyr Ile Gln Pro Asp Thr Pro Gln 
                325                 330                 335     


Pro Ala Ala Pro Ser Asn Gly Ile Thr Met Tyr Gly Ala Thr Gln Ser 
            340                 345                 350         


Gln Ser Asp Met Cys Asp Gln Asp Gln Cys Ile Gln Ser Thr Lys Phe 
        355                 360                 365             


Val Leu Gln Ala Ala Ala Thr Pro Leu Leu Gln Ser Glu Pro Ser Leu 
    370                 375                 380                 


Thr Ser Asp Glu Leu His Leu Pro Gly Lys Pro Gly Leu Gly Thr Pro 
385                 390                 395                 400 


Cys Ala Ser Leu Thr Leu Gly Pro Pro Thr Pro Pro Ala Ser Met Pro 
                405                 410                 415     


Asn Leu Ala Glu Ala Thr Leu Ala Asp Val Met Pro Arg Lys Asp Glu 
            420                 425                 430         


His Met Gly His Gln Phe Leu Thr Pro Asp Glu Ala Pro Ser Pro Pro 
        435                 440                 445             


Arg Leu Leu Ala Ala Gly Ser Pro Leu Ala His Ser Arg Thr Met His 
    450                 455                 460                 


Val Leu Gly Leu Ala Ser Gln Asp Ser Leu His Glu Asp Ser Val Arg 
465                 470                 475                 480 


Gly Leu Val Lys Leu Ser Ser Val 
                485             


<210>  16
<211>  334
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Arg Gly Trp Lys Met Ala Leu Ser Gly Gly Leu Arg Cys Cys 
1               5                   10                  15      


Arg Arg Val Leu Ser Trp Val Pro Val Leu Val Ile Val Leu Val Val 
            20                  25                  30          


Leu Trp Ser Tyr Tyr Ala Tyr Val Phe Glu Leu Cys Leu Val Thr Val 
        35                  40                  45              


Leu Ser Pro Ala Glu Lys Val Ile Tyr Leu Ile Leu Tyr His Ala Ile 
    50                  55                  60                  


Phe Val Phe Phe Thr Trp Thr Tyr Trp Lys Ser Ile Phe Thr Leu Pro 
65                  70                  75                  80  


Gln Gln Pro Asn Gln Lys Phe His Leu Ser Tyr Thr Asp Lys Glu Arg 
                85                  90                  95      


Tyr Glu Asn Glu Glu Arg Pro Glu Val Gln Lys Gln Met Leu Val Asp 
            100                 105                 110         


Met Ala Lys Lys Leu Pro Val Tyr Thr Arg Thr Gly Ser Gly Ala Val 
        115                 120                 125             


Arg Phe Cys Asp Arg Cys His Leu Ile Lys Pro Asp Arg Cys His His 
    130                 135                 140                 


Cys Ser Val Cys Ala Met Cys Val Leu Lys Met Asp His His Cys Pro 
145                 150                 155                 160 


Trp Val Asn Asn Cys Ile Gly Phe Ser Asn Tyr Lys Phe Phe Leu Gln 
                165                 170                 175     


Phe Leu Ala Tyr Ser Val Leu Tyr Cys Leu Tyr Ile Ala Thr Thr Val 
            180                 185                 190         


Phe Ser Tyr Phe Ile Lys Tyr Trp Arg Gly Glu Leu Pro Ser Val Arg 
        195                 200                 205             


Ser Lys Phe His Val Leu Phe Leu Leu Phe Val Ala Cys Met Phe Phe 
    210                 215                 220                 


Val Ser Leu Val Ile Leu Phe Gly Tyr His Cys Trp Leu Val Ser Arg 
225                 230                 235                 240 


Asn Lys Thr Thr Leu Glu Ala Phe Cys Thr Pro Val Phe Thr Ser Gly 
                245                 250                 255     


Pro Glu Lys Asn Gly Phe Asn Leu Gly Phe Ile Lys Asn Ile Gln Gln 
            260                 265                 270         


Val Phe Gly Asp Lys Lys Lys Phe Trp Leu Ile Pro Ile Gly Ser Ser 
        275                 280                 285             


Pro Gly Asp Gly His Ser Phe Pro Met Arg Ser Met Asn Glu Ser Gln 
    290                 295                 300                 


Asn Pro Leu Leu Ala Asn Glu Glu Thr Trp Glu Asp Asn Glu Asp Asp 
305                 310                 315                 320 


Asn Gln Asp Tyr Pro Glu Gly Ser Ser Ser Leu Ala Val Glu 
                325                 330                 


<210>  17
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Arg Gly Gln Arg Ser Leu Leu Leu Gly Pro Ala Arg Leu Cys Leu 
1               5                   10                  15      


Arg Leu Leu Leu Leu Leu Gly Tyr Arg Arg Arg Cys Pro Pro Leu Leu 
            20                  25                  30          


Arg Gly Leu Val Gln Arg Trp Arg Tyr Gly Lys Val Cys Leu Arg Ser 
        35                  40                  45              


Leu Leu Tyr Asn Ser Phe Gly Gly Ser Asp Thr Ala Val Asp Ala Ala 
    50                  55                  60                  


Phe Glu Pro Val Tyr Trp Leu Val Asp Asn Val Ile Arg Trp Phe Gly 
65                  70                  75                  80  


Val Val Phe Val Val Leu Val Ile Val Leu Thr Gly Ser Ile Val Ala 
                85                  90                  95      


Ile Ala Tyr Leu Cys Val Leu Pro Leu Ile Leu Arg Thr Tyr Ser Val 
            100                 105                 110         


Pro Arg Leu Cys Trp His Phe Phe Tyr Ser His Trp Asn Leu Ile Leu 
        115                 120                 125             


Ile Val Phe His Tyr Tyr Gln Ala Ile Thr Thr Pro Pro Gly Tyr Pro 
    130                 135                 140                 


Pro Gln Gly Arg Asn Asp Ile Ala Thr Val Ser Ile Cys Lys Lys Cys 
145                 150                 155                 160 


Ile Tyr Pro Lys Pro Ala Arg Thr His His Cys Ser Ile Cys Asn Arg 
                165                 170                 175     


Cys Val Leu Lys Met Asp His His Cys Pro Trp Leu Asn Asn Cys Val 
            180                 185                 190         


Gly His Tyr Asn His Arg Tyr Phe Phe Ser Phe Cys Phe Phe Met Thr 
        195                 200                 205             


Leu Gly Cys Val Tyr Cys Ser Tyr Gly Ser Trp Asp Leu Phe Arg Glu 
    210                 215                 220                 


Ala Tyr Ala Ala Ile Glu Lys Met Lys Gln Leu Asp Lys Asn Lys Leu 
225                 230                 235                 240 


Gln Ala Val Ala Asn Gln Thr Tyr His Gln Thr Pro Pro Pro Thr Phe 
                245                 250                 255     


Ser Phe Arg Glu Arg Met Thr His Lys Ser Leu Val Tyr Leu Trp Phe 
            260                 265                 270         


Leu Cys Ser Ser Val Ala Leu Ala Leu Gly Ala Leu Thr Val Trp His 
        275                 280                 285             


Ala Val Leu Ile Ser Arg Gly Glu Thr Ser Ile Glu Arg His Ile Asn 
    290                 295                 300                 


Lys Lys Glu Arg Arg Arg Leu Gln Ala Lys Gly Arg Val Phe Arg Asn 
305                 310                 315                 320 


Pro Tyr Asn Tyr Gly Cys Leu Asp Asn Trp Lys Val Phe Leu Gly Val 
                325                 330                 335     


Asp Thr Gly Arg His Trp Leu Thr Arg Val Leu Leu Pro Ser Ser His 
            340                 345                 350         


Leu Pro His Gly Asn Gly Met Ser Trp Glu Pro Pro Pro Trp Val Thr 
        355                 360                 365             


Ala His Ser Ala Ser Val Met Ala Val 
    370                 375         


<210>  18
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gln Arg Glu Glu Gly Phe Asn Thr Lys Met Ala Asp Gly Pro Asp 
1               5                   10                  15      


Glu Tyr Asp Thr Glu Ala Gly Cys Val Pro Leu Leu His Pro Glu Glu 
            20                  25                  30          


Ile Lys Pro Gln Ser His Tyr Asn His Gly Tyr Gly Glu Pro Leu Gly 
        35                  40                  45              


Arg Lys Thr His Ile Asp Asp Tyr Ser Thr Trp Asp Ile Val Lys Ala 
    50                  55                  60                  


Thr Gln Tyr Gly Ile Tyr Glu Arg Cys Arg Glu Leu Val Glu Ala Gly 
65                  70                  75                  80  


Tyr Asp Val Arg Gln Pro Asp Lys Glu Asn Val Thr Leu Leu His Trp 
                85                  90                  95      


Ala Ala Ile Asn Asn Arg Ile Asp Leu Val Lys Tyr Tyr Ile Ser Lys 
            100                 105                 110         


Gly Ala Ile Val Asp Gln Leu Gly Gly Asp Leu Asn Ser Thr Pro Leu 
        115                 120                 125             


His Trp Ala Thr Arg Gln Gly His Leu Ser Met Val Val Gln Leu Met 
    130                 135                 140                 


Lys Tyr Gly Ala Asp Pro Ser Leu Ile Asp Gly Glu Gly Cys Ser Cys 
145                 150                 155                 160 


Ile His Leu Ala Ala Gln Phe Gly His Thr Ser Ile Val Ala Tyr Leu 
                165                 170                 175     


Ile Ala Lys Gly Gln Asp Val Asp Met Met Asp Gln Asn Gly Met Thr 
            180                 185                 190         


Pro Leu Met Trp Ala Ala Tyr Arg Thr His Ser Val Asp Pro Thr Arg 
        195                 200                 205             


Leu Leu Leu Thr Phe Asn Val Ser Val Asn Leu Gly Asp Lys Tyr His 
    210                 215                 220                 


Lys Asn Thr Ala Leu His Trp Ala Val Leu Ala Gly Asn Thr Thr Val 
225                 230                 235                 240 


Ile Ser Leu Leu Leu Glu Ala Gly Ala Asn Val Asp Ala Gln Asn Ile 
                245                 250                 255     


Lys Gly Glu Ser Ala Leu Asp Leu Ala Lys Gln Arg Lys Asn Val Trp 
            260                 265                 270         


Met Ile Asn His Leu Gln Glu Ala Arg Gln Ala Lys Gly Tyr Asp Asn 
        275                 280                 285             


Pro Ser Phe Leu Arg Lys Leu Lys Ala Asp Lys Glu Phe Arg Gln Lys 
    290                 295                 300                 


Val Met Leu Gly Thr Pro Phe Leu Val Ile Trp Leu Val Gly Phe Ile 
305                 310                 315                 320 


Ala Asp Leu Asn Ile Asp Ser Trp Leu Ile Lys Gly Leu Met Tyr Gly 
                325                 330                 335     


Gly Val Trp Ala Thr Val Gln Phe Leu Ser Lys Ser Phe Phe Asp His 
            340                 345                 350         


Ser Met His Ser Ala Leu Pro Leu Gly Ile Tyr Leu Ala Thr Lys Phe 
        355                 360                 365             


Trp Met Tyr Val Thr Trp Phe Phe Trp Phe Trp Asn Asp Leu Asn Phe 
    370                 375                 380                 


Leu Phe Ile His Leu Pro Phe Leu Ala Asn Ser Val Ala Leu Phe Tyr 
385                 390                 395                 400 


Asn Phe Gly Lys Ser Trp Lys Ser Asp Pro Gly Ile Ile Lys Ala Thr 
                405                 410                 415     


Glu Glu Gln Lys Lys Lys Thr Ile Val Glu Leu Ala Glu Thr Gly Ser 
            420                 425                 430         


Leu Asp Leu Ser Ile Phe Cys Ser Thr Cys Leu Ile Arg Lys Pro Val 
        435                 440                 445             


Arg Ser Lys His Cys Gly Val Cys Asn Arg Cys Ile Ala Lys Phe Asp 
    450                 455                 460                 


His His Cys Pro Trp Val Gly Asn Cys Val Gly Ala Gly Asn His Arg 
465                 470                 475                 480 


Tyr Phe Met Gly Tyr Leu Phe Phe Leu Leu Phe Met Ile Cys Trp Met 
                485                 490                 495     


Ile Tyr Gly Cys Ile Ser Tyr Trp Gly Leu His Cys Glu Thr Thr Tyr 
            500                 505                 510         


Thr Lys Asp Gly Phe Trp Thr Tyr Ile Thr Gln Ile Ala Thr Cys Ser 
        515                 520                 525             


Pro Trp Met Phe Trp Met Phe Leu Asn Ser Val Phe His Phe Met Trp 
    530                 535                 540                 


Val Ala Val Leu Leu Met Cys Gln Met Tyr Gln Ile Ser Cys Leu Gly 
545                 550                 555                 560 


Ile Thr Thr Asn Glu Arg Met Asn Ala Arg Arg Tyr Lys His Phe Lys 
                565                 570                 575     


Val Thr Thr Thr Ser Ile Glu Ser Pro Phe Asn His Gly Cys Val Arg 
            580                 585                 590         


Asn Ile Ile Asp Phe Phe Glu Phe Arg Cys Cys Gly Leu Phe Arg Pro 
        595                 600                 605             


Val Ile Val Asp Trp Thr Arg Gln Tyr Thr Ile Glu Tyr Asp Gln Ile 
    610                 615                 620                 


Ser Gly Ser Gly Tyr Gln Leu Val 
625                 630         


<210>  19
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Lys Asp Cys Glu Tyr Gln Gln Ile Ser Pro Gly Ala Ala Pro Leu 
1               5                   10                  15      


Pro Ala Ser Pro Gly Ala Arg Arg Pro Gly Pro Ala Ala Ser Pro Thr 
            20                  25                  30          


Pro Gly Pro Gly Pro Ala Pro Pro Ala Ala Pro Ala Pro Pro Arg Trp 
        35                  40                  45              


Ser Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Leu Gly Arg 
    50                  55                  60                  


Arg Pro Arg Arg Lys Trp Glu Val Phe Pro Gly Arg Asn Arg Phe Tyr 
65                  70                  75                  80  


Cys Gly Gly Arg Leu Met Leu Ala Gly His Gly Gly Val Phe Ala Leu 
                85                  90                  95      


Thr Leu Leu Leu Ile Leu Thr Thr Thr Gly Leu Phe Phe Val Phe Asp 
            100                 105                 110         


Cys Pro Tyr Leu Ala Arg Lys Leu Thr Leu Ala Ile Pro Ile Ile Ala 
        115                 120                 125             


Ala Ile Leu Phe Phe Phe Val Met Ser Cys Leu Leu Gln Thr Ser Phe 
    130                 135                 140                 


Thr Asp Pro Gly Ile Leu Pro Arg Ala Thr Val Cys Glu Ala Ala Ala 
145                 150                 155                 160 


Leu Glu Lys Gln Ile Asp Asn Thr Gly Ser Ser Thr Tyr Arg Pro Pro 
                165                 170                 175     


Pro Arg Thr Arg Glu Val Leu Ile Asn Gly Gln Met Val Lys Leu Lys 
            180                 185                 190         


Tyr Cys Phe Thr Cys Lys Met Phe Arg Pro Pro Arg Thr Ser His Cys 
        195                 200                 205             


Ser Val Cys Asp Asn Cys Val Glu Arg Phe Asp His His Cys Pro Trp 
    210                 215                 220                 


Val Gly Asn Cys Val Gly Arg Arg Asn Tyr Arg Phe Phe Tyr Ala Phe 
225                 230                 235                 240 


Ile Leu Ser Leu Ser Phe Leu Thr Ala Phe Ile Phe Ala Cys Val Val 
                245                 250                 255     


Thr His Leu Thr Leu Arg Ala Gln Gly Ser Asn Phe Leu Ser Thr Leu 
            260                 265                 270         


Lys Glu Thr Pro Ala Ser Val Leu Glu Leu Val Ile Cys Phe Phe Ser 
        275                 280                 285             


Ile Trp Ser Ile Leu Gly Leu Ser Gly Phe His Thr Tyr Leu Val Ala 
    290                 295                 300                 


Ser Asn Leu Thr Thr Asn Glu Asp Ile Lys Gly Ser Trp Ser Ser Lys 
305                 310                 315                 320 


Arg Gly Gly Glu Ala Ser Val Asn Pro Tyr Ser His Lys Ser Ile Ile 
                325                 330                 335     


Thr Asn Cys Cys Ala Val Leu Cys Gly Pro Leu Pro Pro Ser Leu Ile 
            340                 345                 350         


Asp Arg Arg Gly Phe Val Gln Ser Asp Thr Val Leu Pro Ser Pro Ile 
        355                 360                 365             


Arg Ser Asp Glu Pro Ala Cys Arg Ala Lys Pro Asp Ala Ser Met Val 
    370                 375                 380                 


Gly Gly His Pro 
385             


<210>  20
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Thr Leu Leu Thr Asp Ala Thr Pro Leu Val Lys Glu Pro His Pro 
1               5                   10                  15      


Leu Pro Leu Val Pro Arg Pro Trp Phe Leu Pro Ser Leu Phe Ala Ala 
            20                  25                  30          


Phe Asn Val Val Leu Leu Val Phe Phe Ser Gly Leu Phe Phe Ala Phe 
        35                  40                  45              


Pro Cys Arg Trp Leu Ala Gln Asn Gly Glu Trp Ala Phe Pro Val Ile 
    50                  55                  60                  


Thr Gly Ser Leu Phe Val Leu Thr Phe Phe Ser Leu Val Ser Leu Asn 
65                  70                  75                  80  


Phe Ser Asp Pro Gly Ile Leu His Gln Gly Ser Ala Glu Gln Gly Pro 
                85                  90                  95      


Leu Thr Val His Val Val Trp Val Asn His Gly Ala Phe Arg Leu Gln 
            100                 105                 110         


Trp Cys Pro Lys Cys Cys Phe His Arg Pro Pro Arg Thr Tyr His Cys 
        115                 120                 125             


Pro Trp Cys Asn Ile Cys Val Glu Asp Phe Asp His His Cys Lys Trp 
    130                 135                 140                 


Val Asn Asn Cys Ile Gly His Arg Asn Phe Arg Phe Phe Met Leu Leu 
145                 150                 155                 160 


Val Leu Ser Leu Cys Leu Tyr Ser Gly Ala Met Leu Val Thr Cys Leu 
                165                 170                 175     


Ile Phe Leu Val Arg Thr Thr His Leu Pro Phe Ser Thr Asp Lys Ala 
            180                 185                 190         


Ile Ala Ile Val Val Ala Val Ser Ala Ala Gly Leu Leu Val Pro Leu 
        195                 200                 205             


Ser Leu Leu Leu Leu Ile Gln Ala Leu Ser Val Ser Ser Ala Asp Arg 
    210                 215                 220                 


Thr Tyr Lys Gly Lys Cys Arg His Leu Gln Gly Tyr Asn Pro Phe Asp 
225                 230                 235                 240 


Gln Gly Cys Ala Ser Asn Trp Tyr Leu Thr Ile Cys Ala Pro Leu Gly 
                245                 250                 255     


Pro Lys Tyr Met Ala Glu Ala Val Gln Leu Gln Arg Val Val Gly Pro 
            260                 265                 270         


Asp Trp Thr Ser Met Pro Asn Leu His Pro Pro Met Ser Pro Ser Ala 
        275                 280                 285             


Leu Asn Pro Pro Ala Pro Thr Ser Gly Ser Leu Gln Ser Arg Glu Gly 
    290                 295                 300                 


Thr Pro Gly Ala Trp 
305                 


<210>  21
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Pro Trp Thr Leu Trp Arg Cys Cys Gln Arg Val Val Gly Trp 
1               5                   10                  15      


Val Pro Val Leu Phe Ile Thr Phe Val Val Val Trp Ser Tyr Tyr Ala 
            20                  25                  30          


Tyr Val Val Glu Leu Cys Val Phe Thr Ile Phe Gly Asn Glu Glu Asn 
        35                  40                  45              


Gly Lys Thr Val Val Tyr Leu Val Ala Phe His Leu Phe Phe Val Met 
    50                  55                  60                  


Phe Val Trp Ser Tyr Trp Met Thr Ile Phe Thr Ser Pro Ala Ser Pro 
65                  70                  75                  80  


Ser Lys Glu Phe Tyr Leu Ser Asn Ser Glu Lys Glu Arg Tyr Glu Lys 
                85                  90                  95      


Glu Phe Ser Gln Glu Arg Gln Gln Glu Ile Leu Arg Arg Ala Ala Arg 
            100                 105                 110         


Ala Leu Pro Ile Tyr Thr Thr Ser Ala Ser Lys Thr Ile Arg Tyr Cys 
        115                 120                 125             


Glu Lys Cys Gln Leu Ile Lys Pro Asp Arg Ala His His Cys Ser Ala 
    130                 135                 140                 


Cys Asp Ser Cys Ile Leu Lys Met Asp His His Cys Pro Trp Val Asn 
145                 150                 155                 160 


Asn Cys Val Gly Phe Ser Asn Tyr Lys Phe Phe Leu Leu Phe Leu Leu 
                165                 170                 175     


Tyr Ser Leu Leu Tyr Cys Leu Phe Val Ala Ala Thr Val Leu Glu Tyr 
            180                 185                 190         


Phe Ile Lys Phe Trp Thr Asn Glu Leu Thr Asp Thr Arg Ala Lys Phe 
        195                 200                 205             


His Val Leu Phe Leu Phe Phe Val Ser Ala Met Phe Phe Ile Ser Val 
    210                 215                 220                 


Leu Ser Leu Phe Ser Tyr His Cys Trp Leu Val Gly Lys Asn Arg Thr 
225                 230                 235                 240 


Thr Ile Glu Ser Phe Arg Ala Pro Thr Phe Ser Tyr Gly Pro Asp Gly 
                245                 250                 255     


Asn Gly Phe Ser Leu Gly Cys Ser Lys Asn Trp Arg Gln Val Phe Gly 
            260                 265                 270         


Asp Glu Lys Lys Tyr Trp Leu Leu Pro Ile Phe Ser Ser Leu Gly Asp 
        275                 280                 285             


Gly Cys Ser Phe Pro Thr Arg Leu Val Gly Met Asp Pro Glu Gln Ala 
    290                 295                 300                 


Ser Val Thr Asn Gln Asn Glu Tyr Ala Arg Ser Gly Ser Asn Gln Pro 
305                 310                 315                 320 


Phe Pro Ile Lys Pro Leu Ser Glu Ser Lys Asn Arg Leu Leu Asp Ser 
                325                 330                 335     


Glu Ser Gln Trp Leu Glu Asn Gly Ala Glu Glu Gly Ile Val Lys Ser 
            340                 345                 350         


Gly Val 
        


<210>  22
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Leu Arg Ile His Phe Val Val Asp Pro His Gly Trp Cys Cys 
1               5                   10                  15      


Met Gly Leu Ile Val Phe Val Trp Leu Tyr Asn Ile Val Leu Ile Pro 
            20                  25                  30          


Lys Ile Val Leu Phe Pro His Tyr Glu Glu Gly His Ile Pro Gly Ile 
        35                  40                  45              


Leu Ile Ile Ile Phe Tyr Gly Ile Ser Ile Phe Cys Leu Val Ala Leu 
    50                  55                  60                  


Val Arg Ala Ser Ile Thr Asp Pro Gly Arg Leu Pro Glu Asn Pro Lys 
65                  70                  75                  80  


Ile Pro His Gly Glu Arg Glu Phe Trp Glu Leu Cys Asn Lys Cys Asn 
                85                  90                  95      


Leu Met Arg Pro Lys Arg Ser His His Cys Ser Arg Cys Gly His Cys 
            100                 105                 110         


Val Arg Arg Met Asp His His Cys Pro Trp Ile Asn Asn Cys Val Gly 
        115                 120                 125             


Glu Asp Asn His Trp Leu Phe Leu Gln Leu Cys Phe Tyr Thr Glu Leu 
    130                 135                 140                 


Leu Thr Cys Tyr Ala Leu Met Phe Ser Phe Cys His Tyr Tyr Tyr Phe 
145                 150                 155                 160 


Leu Pro Leu Lys Lys Arg Asn Leu Asp Leu Phe Val Phe Arg His Glu 
                165                 170                 175     


Leu Ala Ile Met Arg Leu Ala Ala Phe Met Gly Ile Thr Met Leu Val 
            180                 185                 190         


Gly Ile Thr Gly Leu Phe Tyr Thr Gln Leu Ile Gly Ile Ile Thr Asp 
        195                 200                 205             


Thr Thr Ser Ile Glu Lys Met Ser Asn Cys Cys Glu Asp Ile Ser Arg 
    210                 215                 220                 


Pro Arg Lys Pro Trp Gln Gln Thr Phe Ser Glu Val Phe Gly Thr Arg 
225                 230                 235                 240 


Trp Lys Ile Leu Trp Phe Ile Pro Phe Arg Gln Arg Gln Pro Leu Arg 
                245                 250                 255     


Val Pro Tyr His Phe Ala Asn His Val 
            260                 265 


<210>  23
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Leu Ala Leu Arg Leu Leu Asn Val Val Ala Pro Ala Tyr Phe Leu 
1               5                   10                  15      


Cys Ile Ser Leu Val Thr Phe Val Leu Gln Leu Phe Leu Phe Leu Pro 
            20                  25                  30          


Ser Met Arg Glu Asp Pro Ala Ala Ala Arg Leu Phe Ser Pro Ala Leu 
        35                  40                  45              


Leu His Gly Ala Leu Phe Leu Phe Leu Ser Ala Asn Ala Leu Gly Asn 
    50                  55                  60                  


Tyr Val Leu Val Ile Gln Asn Ser Pro Asp Asp Leu Gly Ala Cys Gln 
65                  70                  75                  80  


Gly Ala Ser Ala Arg Lys Thr Pro Cys Pro Ser Pro Ser Thr His Phe 
                85                  90                  95      


Cys Arg Val Cys Ala Arg Val Thr Leu Arg His Asp His His Cys Phe 
            100                 105                 110         


Phe Thr Gly Asn Cys Ile Gly Ser Arg Asn Met Arg Asn Phe Val Leu 
        115                 120                 125             


Phe Cys Leu Tyr Thr Ser Leu Ala Cys Leu Tyr Ser Met Val Ala Gly 
    130                 135                 140                 


Val Ala Tyr Ile Ser Ala Val Leu Ser Ile Ser Phe Ala His Pro Leu 
145                 150                 155                 160 


Ala Phe Leu Thr Leu Leu Pro Thr Ser Ile Ser Gln Phe Phe Ser Gly 
                165                 170                 175     


Ala Val Leu Gly Ser Glu Met Phe Val Ile Leu Met Leu Tyr Leu Trp 
            180                 185                 190         


Phe Ala Ile Gly Leu Ala Cys Ala Gly Phe Cys Cys His Gln Leu Leu 
        195                 200                 205             


Leu Ile Leu Arg Gly Gln Thr Arg His Gln Val Arg Lys Gly Val Ala 
    210                 215                 220                 


Val Arg Ala Arg Pro Trp Arg Lys Asn Leu Gln Glu Val Phe Gly Lys 
225                 230                 235                 240 


Arg Trp Leu Leu Gly Leu Leu Val Pro Met Phe Asn Val Gly Ser Glu 
                245                 250                 255     


Ser Ser Lys Gln Gln Asp Lys 
            260             


<210>  24
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Thr Gln Lys Gly Ser Met Lys Pro Val Lys Lys Lys Lys Thr Glu 
1               5                   10                  15      


Glu Pro Glu Leu Glu Pro Leu Cys Cys Cys Glu Tyr Ile Asp Arg Asn 
            20                  25                  30          


Gly Glu Lys Asn His Val Ala Thr Cys Leu Cys Asp Cys Gln Asp Leu 
        35                  40                  45              


Asp Glu Gly Cys Asp Arg Trp Ile Thr Cys Lys Ser Leu Gln Pro Glu 
    50                  55                  60                  


Thr Cys Glu Arg Ile Met Asp Thr Ile Ser Asp Arg Leu Arg Ile Pro 
65                  70                  75                  80  


Trp Leu Arg Gly Ala Lys Lys Val Asn Ile Ser Ile Ile Pro Pro Leu 
                85                  90                  95      


Val Leu Leu Pro Val Phe Leu His Val Ala Ser Trp His Phe Leu Leu 
            100                 105                 110         


Gly Val Val Val Leu Thr Ser Leu Pro Val Leu Ala Leu Trp Tyr Tyr 
        115                 120                 125             


Tyr Leu Thr His Arg Arg Lys Glu Gln Thr Leu Phe Phe Leu Ser Leu 
    130                 135                 140                 


Gly Leu Phe Ser Leu Gly Tyr Met Tyr Tyr Val Phe Leu Gln Glu Val 
145                 150                 155                 160 


Val Pro Lys Gly Arg Val Gly Pro Val Gln Leu Ala Val Leu Thr Cys 
                165                 170                 175     


Gly Leu Phe Leu Ile Leu Leu Ala Leu His Arg Ala Lys Lys Asn Pro 
            180                 185                 190         


Gly Tyr Leu Ser Asn Pro Ala Ser Gly Asp Arg Ser Leu Ser Ser Ser 
        195                 200                 205             


Gln Leu Glu Cys Leu Ser Arg Lys Gly Gln Glu Lys Thr Lys Gly Phe 
    210                 215                 220                 


Pro Gly Ala Asp Met Ser Gly Ser Leu Asn Asn Arg Thr Thr Lys Asp 
225                 230                 235                 240 


Asp Pro Lys Gly Ser Ser Lys Met Pro Ala Gly Ser Pro Thr Lys Ala 
                245                 250                 255     


Lys Glu Asp Trp Cys Ala Lys Cys Gln Leu Val Arg Pro Ala Arg Ala 
            260                 265                 270         


Trp His Cys Arg Ile Cys Gly Ile Cys Val Arg Arg Met Asp His His 
        275                 280                 285             


Cys Val Trp Ile Asn Ser Cys Val Gly Glu Ser Asn His Gln Ala Phe 
    290                 295                 300                 


Ile Leu Ala Leu Leu Ile Phe Leu Leu Thr Ser Val Tyr Gly Ile Thr 
305                 310                 315                 320 


Leu Thr Leu Asp Thr Ile Cys Arg Asp Arg Ser Val Phe Thr Ala Leu 
                325                 330                 335     


Phe Tyr Cys Pro Gly Val Tyr Ala Asn Tyr Ser Ser Ala Leu Ser Phe 
            340                 345                 350         


Thr Cys Val Trp Tyr Ser Val Ile Ile Thr Ala Gly Met Ala Tyr Ile 
        355                 360                 365             


Phe Leu Ile Gln Leu Ile Asn Ile Ser Tyr Asn Val Thr Glu Arg Glu 
    370                 375                 380                 


Val Gln Gln Ala Leu Arg Gln Lys Thr Gly Arg Arg Leu Leu Cys Gly 
385                 390                 395                 400 


Leu Ile Val Asp Thr Gly Leu Leu Gly 
                405                 


<210>  25
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Gln Pro Trp Ala Ala Gly Ser Thr Asp Gly Ala Pro Ala Gln 
1               5                   10                  15      


Leu Pro Leu Val Leu Thr Ala Leu Trp Ala Ala Ala Val Gly Leu Glu 
            20                  25                  30          


Leu Ala Tyr Val Leu Val Leu Gly Pro Gly Pro Pro Pro Leu Gly Pro 
        35                  40                  45              


Leu Ala Arg Ala Leu Gln Leu Ala Leu Ala Ala Phe Gln Leu Leu Asn 
    50                  55                  60                  


Leu Leu Gly Asn Val Gly Leu Phe Leu Arg Ser Asp Pro Ser Ile Arg 
65                  70                  75                  80  


Gly Val Met Leu Ala Gly Arg Gly Leu Gly Gln Gly Trp Ala Tyr Cys 
                85                  90                  95      


Tyr Gln Cys Gln Ser Gln Val Pro Pro Arg Ser Gly His Cys Ser Ala 
            100                 105                 110         


Cys Arg Val Cys Ile Leu Arg Arg Asp His His Cys Arg Leu Leu Gly 
        115                 120                 125             


Arg Cys Val Gly Phe Gly Asn Tyr Arg Pro Phe Leu Cys Leu Leu Leu 
    130                 135                 140                 


His Ala Ala Gly Val Leu Leu His Val Ser Val Leu Leu Gly Pro Ala 
145                 150                 155                 160 


Leu Ser Ala Leu Leu Arg Ala His Thr Pro Leu His Met Ala Ala Leu 
                165                 170                 175     


Leu Leu Leu Pro Trp Leu Met Leu Leu Thr Gly Arg Val Ser Leu Ala 
            180                 185                 190         


Gln Phe Ala Leu Ala Phe Val Thr Asp Thr Cys Val Ala Gly Ala Leu 
        195                 200                 205             


Leu Cys Gly Ala Gly Leu Leu Phe His Gly Met Leu Leu Leu Arg Gly 
    210                 215                 220                 


Gln Thr Thr Trp Glu Trp Ala Arg Gly Gln His Ser Tyr Asp Leu Gly 
225                 230                 235                 240 


Pro Cys His Asn Leu Gln Ala Ala Leu Gly Pro Arg Trp Ala Leu Val 
                245                 250                 255     


Trp Leu Trp Pro Phe Leu Ala Ser Pro Leu Pro Gly Asp Gly Ile Thr 
            260                 265                 270         


Phe Gln Thr Thr Ala Asp Val Gly His Thr Ala Ser 
        275                 280                 


<210>  26
<211>  2511
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Glu Glu Val Val Ile Ala Gly Met Ser Gly Lys Leu Pro Glu Ser 
1               5                   10                  15      


Glu Asn Leu Gln Glu Phe Trp Asp Asn Leu Ile Gly Gly Val Asp Met 
            20                  25                  30          


Val Thr Asp Asp Asp Arg Arg Trp Lys Ala Gly Leu Tyr Gly Leu Pro 
        35                  40                  45              


Arg Arg Ser Gly Lys Leu Lys Asp Leu Ser Arg Phe Asp Ala Ser Phe 
    50                  55                  60                  


Phe Gly Val His Pro Lys Gln Ala His Thr Met Asp Pro Gln Leu Arg 
65                  70                  75                  80  


Leu Leu Leu Glu Val Thr Tyr Glu Ala Ile Val Asp Gly Gly Ile Asn 
                85                  90                  95      


Pro Asp Ser Leu Arg Gly Thr His Thr Gly Val Trp Val Gly Val Ser 
            100                 105                 110         


Gly Ser Glu Thr Ser Glu Ala Leu Ser Arg Asp Pro Glu Thr Leu Val 
        115                 120                 125             


Gly Tyr Ser Met Val Gly Cys Gln Arg Ala Met Met Ala Asn Arg Leu 
    130                 135                 140                 


Ser Phe Phe Phe Asp Phe Arg Gly Pro Ser Ile Ala Leu Asp Thr Ala 
145                 150                 155                 160 


Cys Ser Ser Ser Leu Met Ala Leu Gln Asn Ala Tyr Gln Ala Ile His 
                165                 170                 175     


Ser Gly Gln Cys Pro Ala Ala Ile Val Gly Gly Ile Asn Val Leu Leu 
            180                 185                 190         


Lys Pro Asn Thr Ser Val Gln Phe Leu Arg Leu Gly Met Leu Ser Pro 
        195                 200                 205             


Glu Gly Thr Cys Lys Ala Phe Asp Thr Ala Gly Asn Gly Tyr Cys Arg 
    210                 215                 220                 


Ser Glu Gly Val Val Ala Val Leu Leu Thr Lys Lys Ser Leu Ala Arg 
225                 230                 235                 240 


Arg Val Tyr Ala Thr Ile Leu Asn Ala Gly Thr Asn Thr Asp Gly Phe 
                245                 250                 255     


Lys Glu Gln Gly Val Thr Phe Pro Ser Gly Asp Ile Gln Glu Gln Leu 
            260                 265                 270         


Ile Arg Ser Leu Tyr Gln Ser Ala Gly Val Ala Pro Glu Ser Phe Glu 
        275                 280                 285             


Tyr Ile Glu Ala His Gly Thr Gly Thr Lys Val Gly Asp Pro Gln Glu 
    290                 295                 300                 


Leu Asn Gly Ile Thr Arg Ala Leu Cys Ala Thr Arg Gln Glu Pro Leu 
305                 310                 315                 320 


Leu Ile Gly Ser Thr Lys Ser Asn Met Gly His Pro Glu Pro Ala Ser 
                325                 330                 335     


Gly Leu Ala Ala Leu Ala Lys Val Leu Leu Ser Leu Glu His Gly Leu 
            340                 345                 350         


Trp Ala Pro Asn Leu His Phe His Ser Pro Asn Pro Glu Ile Pro Ala 
        355                 360                 365             


Leu Leu Asp Gly Arg Leu Gln Val Val Asp Gln Pro Leu Pro Val Arg 
    370                 375                 380                 


Gly Gly Asn Val Gly Ile Asn Ser Phe Gly Phe Gly Gly Ser Asn Val 
385                 390                 395                 400 


His Ile Ile Leu Arg Pro Asn Thr Gln Pro Pro Pro Ala Pro Ala Pro 
                405                 410                 415     


His Ala Thr Leu Pro Arg Leu Leu Arg Ala Ser Gly Arg Thr Pro Glu 
            420                 425                 430         


Ala Val Gln Lys Leu Leu Glu Gln Gly Leu Arg His Ser Gln Asp Leu 
        435                 440                 445             


Ala Phe Leu Ser Met Leu Asn Asp Ile Ala Ala Val Pro Ala Thr Ala 
    450                 455                 460                 


Met Pro Phe Arg Gly Tyr Ala Val Leu Gly Gly Glu Arg Gly Gly Pro 
465                 470                 475                 480 


Glu Val Gln Gln Val Pro Ala Gly Glu Arg Pro Leu Trp Phe Ile Cys 
                485                 490                 495     


Ser Gly Met Gly Thr Gln Trp Arg Gly Met Gly Leu Ser Leu Met Arg 
            500                 505                 510         


Leu Asp Arg Phe Arg Asp Ser Ile Leu Arg Ser Asp Glu Ala Val Lys 
        515                 520                 525             


Pro Phe Gly Leu Lys Val Ser Gln Leu Leu Leu Ser Thr Asp Glu Ser 
    530                 535                 540                 


Thr Phe Asp Asp Ile Val His Ser Phe Val Ser Leu Thr Ala Ile Gln 
545                 550                 555                 560 


Ile Gly Leu Ile Asp Leu Leu Ser Cys Met Gly Leu Arg Pro Asp Gly 
                565                 570                 575     


Ile Val Gly His Ser Leu Gly Glu Val Ala Cys Gly Tyr Ala Asp Gly 
            580                 585                 590         


Cys Leu Ser Gln Glu Glu Ala Val Leu Ala Ala Tyr Trp Arg Gly Gln 
        595                 600                 605             


Cys Ile Lys Glu Ala His Leu Pro Pro Gly Ala Met Ala Ala Val Gly 
    610                 615                 620                 


Leu Ser Trp Glu Glu Cys Lys Gln Arg Cys Pro Pro Gly Val Val Pro 
625                 630                 635                 640 


Ala Cys His Asn Ser Lys Asp Thr Val Thr Ile Ser Gly Pro Gln Ala 
                645                 650                 655     


Pro Val Phe Glu Phe Val Glu Gln Leu Arg Lys Glu Gly Val Phe Ala 
            660                 665                 670         


Lys Glu Val Arg Thr Gly Gly Met Ala Phe His Ser Tyr Phe Met Glu 
        675                 680                 685             


Ala Ile Ala Pro Pro Leu Leu Gln Glu Leu Lys Lys Val Ile Arg Glu 
    690                 695                 700                 


Pro Lys Pro Arg Ser Ala Arg Trp Leu Ser Thr Ser Ile Pro Glu Ala 
705                 710                 715                 720 


Gln Trp His Ser Ser Leu Ala Arg Thr Ser Ser Ala Glu Tyr Asn Val 
                725                 730                 735     


Asn Asn Leu Val Ser Pro Val Leu Phe Gln Glu Ala Leu Trp His Val 
            740                 745                 750         


Pro Glu His Ala Val Val Leu Glu Ile Ala Pro His Ala Leu Leu Gln 
        755                 760                 765             


Ala Val Leu Lys Arg Gly Leu Lys Pro Ser Cys Thr Ile Ile Pro Leu 
    770                 775                 780                 


Met Lys Lys Asp His Arg Asp Asn Leu Glu Phe Phe Leu Ala Gly Ile 
785                 790                 795                 800 


Gly Arg Leu His Leu Ser Gly Ile Asp Ala Asn Pro Asn Ala Leu Phe 
                805                 810                 815     


Pro Pro Val Glu Phe Pro Ala Pro Arg Gly Thr Pro Leu Ile Ser Pro 
            820                 825                 830         


Leu Ile Lys Trp Asp His Ser Leu Ala Trp Asp Val Pro Ala Ala Glu 
        835                 840                 845             


Asp Phe Pro Asn Gly Ser Gly Ser Pro Ser Ala Ala Ile Tyr Asn Ile 
    850                 855                 860                 


Asp Thr Ser Ser Glu Ser Pro Asp His Tyr Leu Val Asp His Thr Leu 
865                 870                 875                 880 


Asp Gly Arg Val Leu Phe Pro Ala Thr Gly Tyr Leu Ser Ile Val Trp 
                885                 890                 895     


Lys Thr Leu Ala Arg Ala Leu Gly Leu Gly Val Glu Gln Leu Pro Val 
            900                 905                 910         


Val Phe Glu Asp Val Val Leu His Gln Ala Thr Ile Leu Pro Lys Thr 
        915                 920                 925             


Gly Thr Val Ser Leu Glu Val Arg Leu Leu Glu Ala Ser Arg Ala Phe 
    930                 935                 940                 


Glu Val Ser Glu Asn Gly Asn Leu Val Val Ser Gly Lys Val Tyr Gln 
945                 950                 955                 960 


Trp Asp Asp Pro Asp Pro Arg Leu Phe Asp His Pro Glu Ser Pro Thr 
                965                 970                 975     


Pro Asn Pro Thr Glu Pro Leu Phe Leu Ala Gln Ala Glu Val Tyr Lys 
            980                 985                 990         


Glu Leu Arg Leu Arg Gly Tyr Asp  Tyr Gly Pro His Phe  Gln Gly Ile 
        995                 1000                 1005             


Leu Glu  Ala Ser Leu Glu Gly  Asp Ser Gly Arg Leu  Leu Trp Lys 
    1010                 1015                 1020             


Asp Asn  Trp Val Ser Phe Met  Asp Thr Met Leu Gln  Met Ser Ile 
    1025                 1030                 1035             


Leu Gly  Ser Ala Lys His Gly  Leu Tyr Leu Pro Thr  Arg Val Thr 
    1040                 1045                 1050             


Ala Ile  His Ile Asp Pro Ala  Thr His Arg Gln Lys  Leu Tyr Thr 
    1055                 1060                 1065             


Leu Gln  Asp Lys Ala Gln Val  Ala Asp Val Val Val  Ser Arg Trp 
    1070                 1075                 1080             


Leu Arg  Val Thr Val Ala Gly  Gly Val His Ile Ser  Gly Leu His 
    1085                 1090                 1095             


Thr Glu  Ser Ala Pro Arg Arg  Gln Gln Glu Gln Gln  Val Pro Ile 
    1100                 1105                 1110             


Leu Glu  Lys Phe Cys Phe Thr  Pro His Thr Glu Glu  Gly Cys Leu 
    1115                 1120                 1125             


Ser Glu  Arg Ala Ala Leu Gln  Glu Glu Leu Gln Leu  Cys Lys Gly 
    1130                 1135                 1140             


Leu Val  Gln Ala Leu Gln Thr  Lys Val Thr Gln Gln  Gly Leu Lys 
    1145                 1150                 1155             


Met Val  Val Pro Gly Leu Asp  Gly Ala Gln Ile Pro  Arg Asp Pro 
    1160                 1165                 1170             


Ser Gln  Gln Glu Leu Pro Arg  Leu Leu Ser Ala Ala  Cys Arg Leu 
    1175                 1180                 1185             


Gln Leu  Asn Gly Asn Leu Gln  Leu Glu Leu Ala Gln  Val Leu Ala 
    1190                 1195                 1200             


Gln Glu  Arg Pro Lys Leu Pro  Glu Asp Pro Leu Leu  Ser Gly Leu 
    1205                 1210                 1215             


Leu Asp  Ser Pro Ala Leu Lys  Ala Cys Leu Asp Thr  Ala Val Glu 
    1220                 1225                 1230             


Asn Met  Pro Ser Leu Lys Met  Lys Val Val Glu Val  Leu Ala Gly 
    1235                 1240                 1245             


His Gly  His Leu Tyr Ser Arg  Ile Pro Gly Leu Leu  Ser Pro His 
    1250                 1255                 1260             


Pro Leu  Leu Gln Leu Ser Tyr  Thr Ala Thr Asp Arg  His Pro Gln 
    1265                 1270                 1275             


Ala Leu  Glu Ala Ala Gln Ala  Glu Leu Gln Gln His  Asp Val Ala 
    1280                 1285                 1290             


Gln Gly  Gln Trp Asp Pro Ala  Asp Pro Ala Pro Ser  Ala Leu Gly 
    1295                 1300                 1305             


Ser Ala  Asp Leu Leu Val Cys  Asn Cys Ala Val Ala  Ala Leu Gly 
    1310                 1315                 1320             


Asp Pro  Ala Ser Ala Leu Ser  Asn Met Val Ala Ala  Leu Arg Glu 
    1325                 1330                 1335             


Gly Gly  Phe Leu Leu Leu His  Thr Leu Leu Arg Gly  His Pro Leu 
    1340                 1345                 1350             


Gly Asp  Ile Val Ala Phe Leu  Thr Ser Thr Glu Pro  Gln Tyr Gly 
    1355                 1360                 1365             


Gln Gly  Ile Leu Ser Gln Asp  Ala Trp Glu Ser Leu  Phe Ser Arg 
    1370                 1375                 1380             


Val Ser  Leu Arg Leu Val Gly  Leu Lys Lys Ser Phe  Tyr Gly Ser 
    1385                 1390                 1395             


Thr Leu  Phe Leu Cys Arg Arg  Pro Thr Pro Gln Asp  Ser Pro Ile 
    1400                 1405                 1410             


Phe Leu  Pro Val Asp Asp Thr  Ser Phe Arg Trp Val  Glu Ser Leu 
    1415                 1420                 1425             


Lys Gly  Ile Leu Ala Asp Glu  Asp Ser Ser Arg Pro  Val Trp Leu 
    1430                 1435                 1440             


Lys Ala  Ile Asn Cys Ala Thr  Ser Gly Val Val Gly  Leu Val Asn 
    1445                 1450                 1455             


Cys Leu  Arg Arg Glu Pro Gly  Gly Asn Arg Leu Arg  Cys Val Leu 
    1460                 1465                 1470             


Leu Ser  Asn Leu Ser Ser Thr  Ser His Val Pro Glu  Val Asp Pro 
    1475                 1480                 1485             


Gly Ser  Ala Glu Leu Gln Lys  Val Leu Gln Gly Asp  Leu Val Met 
    1490                 1495                 1500             


Asn Val  Tyr Arg Asp Gly Ala  Trp Gly Ala Phe Arg  His Phe Leu 
    1505                 1510                 1515             


Leu Glu  Glu Asp Lys Pro Glu  Glu Pro Thr Ala His  Ala Phe Val 
    1520                 1525                 1530             


Ser Thr  Leu Thr Arg Gly Asp  Leu Ser Ser Ile Arg  Trp Val Cys 
    1535                 1540                 1545             


Ser Ser  Leu Arg His Ala Gln  Pro Thr Cys Pro Gly  Ala Gln Leu 
    1550                 1555                 1560             


Cys Thr  Val Tyr Tyr Ala Ser  Leu Asn Phe Arg Asp  Ile Met Leu 
    1565                 1570                 1575             


Ala Thr  Gly Lys Leu Ser Pro  Asp Ala Ile Pro Gly  Lys Trp Thr 
    1580                 1585                 1590             


Ser Gln  Asp Ser Leu Leu Gly  Met Glu Phe Ser Gly  Arg Asp Ala 
    1595                 1600                 1605             


Ser Gly  Lys Arg Val Met Gly  Leu Val Pro Ala Lys  Gly Leu Ala 
    1610                 1615                 1620             


Thr Ser  Val Leu Leu Ser Pro  Asp Phe Leu Trp Asp  Val Pro Ser 
    1625                 1630                 1635             


Asn Trp  Thr Leu Glu Glu Ala  Ala Ser Val Pro Val  Val Tyr Ser 
    1640                 1645                 1650             


Thr Ala  Tyr Tyr Ala Leu Val  Val Arg Gly Arg Val  Arg Pro Gly 
    1655                 1660                 1665             


Glu Thr  Leu Leu Ile His Ser  Gly Ser Gly Gly Val  Gly Gln Ala 
    1670                 1675                 1680             


Ala Ile  Ala Ile Ala Leu Ser  Leu Gly Cys Arg Val  Phe Thr Thr 
    1685                 1690                 1695             


Val Gly  Ser Ala Glu Lys Arg  Ala Tyr Leu Gln Ala  Arg Phe Pro 
    1700                 1705                 1710             


Gln Leu  Asp Ser Thr Ser Phe  Ala Asn Ser Arg Asp  Thr Ser Phe 
    1715                 1720                 1725             


Glu Gln  His Val Leu Trp His  Thr Gly Gly Lys Gly  Val Asp Leu 
    1730                 1735                 1740             


Val Leu  Asn Ser Leu Ala Glu  Glu Lys Leu Gln Ala  Ser Val Arg 
    1745                 1750                 1755             


Cys Leu  Ala Thr His Gly Arg  Phe Leu Glu Ile Gly  Lys Phe Asp 
    1760                 1765                 1770             


Leu Ser  Gln Asn His Pro Leu  Gly Met Ala Ile Phe  Leu Lys Asn 
    1775                 1780                 1785             


Val Thr  Phe His Gly Val Leu  Leu Asp Ala Phe Phe  Asn Glu Ser 
    1790                 1795                 1800             


Ser Ala  Asp Trp Arg Glu Val  Trp Ala Leu Val Gln  Ala Gly Ile 
    1805                 1810                 1815             


Arg Asp  Gly Val Val Arg Pro  Leu Lys Cys Thr Val  Phe His Gly 
    1820                 1825                 1830             


Ala Gln  Val Glu Asp Ala Phe  Arg Tyr Met Ala Gln  Gly Lys His 
    1835                 1840                 1845             


Ile Gly  Lys Val Val Val Gln  Val Leu Ala Glu Glu  Pro Glu Ala 
    1850                 1855                 1860             


Val Leu  Lys Gly Ala Lys Pro  Lys Leu Met Ser Ala  Ile Ser Lys 
    1865                 1870                 1875             


Thr Phe  Cys Pro Ala His Lys  Ser Tyr Ile Ile Ala  Gly Gly Leu 
    1880                 1885                 1890             


Gly Gly  Phe Gly Leu Glu Leu  Ala Gln Trp Leu Ile  Gln Arg Gly 
    1895                 1900                 1905             


Val Gln  Lys Leu Val Leu Thr  Ser Arg Ser Gly Ile  Arg Thr Gly 
    1910                 1915                 1920             


Tyr Gln  Ala Lys Gln Val Arg  Arg Trp Arg Arg Gln  Gly Val Gln 
    1925                 1930                 1935             


Val Gln  Val Ser Thr Ser Asn  Ile Ser Ser Leu Glu  Gly Ala Arg 
    1940                 1945                 1950             


Gly Leu  Ile Ala Glu Ala Ala  Gln Leu Gly Pro Val  Gly Gly Val 
    1955                 1960                 1965             


Phe Asn  Leu Ala Val Val Leu  Arg Asp Gly Leu Leu  Glu Asn Gln 
    1970                 1975                 1980             


Thr Pro  Glu Phe Phe Gln Asp  Val Cys Lys Pro Lys  Tyr Ser Gly 
    1985                 1990                 1995             


Thr Leu  Asn Leu Asp Arg Val  Thr Arg Glu Ala Cys  Pro Glu Leu 
    2000                 2005                 2010             


Asp Tyr  Phe Val Val Phe Ser  Ser Val Ser Cys Gly  Arg Gly Asn 
    2015                 2020                 2025             


Ala Gly  Gln Ser Asn Tyr Gly  Phe Ala Asn Ser Ala  Met Glu Arg 
    2030                 2035                 2040             


Ile Cys  Glu Lys Arg Arg His  Glu Gly Leu Pro Gly  Leu Ala Val 
    2045                 2050                 2055             


Gln Trp  Gly Ala Ile Gly Asp  Val Gly Ile Leu Val  Glu Thr Met 
    2060                 2065                 2070             


Ser Thr  Asn Asp Thr Ile Val  Ser Gly Thr Leu Pro  Gln Arg Met 
    2075                 2080                 2085             


Ala Ser  Cys Leu Glu Val Leu  Asp Leu Phe Leu Asn  Gln Pro His 
    2090                 2095                 2100             


Met Val  Leu Ser Ser Phe Val  Leu Ala Glu Lys Ala  Ala Ala Tyr 
    2105                 2110                 2115             


Arg Asp  Arg Asp Ser Gln Arg  Asp Leu Val Glu Ala  Val Ala His 
    2120                 2125                 2130             


Ile Leu  Gly Ile Arg Asp Leu  Ala Ala Val Asn Leu  Asp Ser Ser 
    2135                 2140                 2145             


Leu Ala  Asp Leu Gly Leu Asp  Ser Leu Met Ser Val  Glu Val Arg 
    2150                 2155                 2160             


Gln Thr  Leu Glu Arg Glu Leu  Asn Leu Val Leu Ser  Val Arg Glu 
    2165                 2170                 2175             


Val Arg  Gln Leu Thr Leu Arg  Lys Leu Gln Glu Leu  Ser Ser Lys 
    2180                 2185                 2190             


Ala Asp  Glu Ala Ser Glu Leu  Ala Cys Pro Thr Pro  Lys Glu Asp 
    2195                 2200                 2205             


Gly Leu  Ala Gln Gln Gln Thr  Gln Leu Asn Leu Arg  Ser Leu Leu 
    2210                 2215                 2220             


Val Asn  Pro Glu Gly Pro Thr  Leu Met Arg Leu Asn  Ser Val Gln 
    2225                 2230                 2235             


Ser Ser  Glu Arg Pro Leu Phe  Leu Val His Pro Ile  Glu Gly Ser 
    2240                 2245                 2250             


Thr Thr  Val Phe His Ser Leu  Ala Ser Arg Leu Ser  Ile Pro Thr 
    2255                 2260                 2265             


Tyr Gly  Leu Gln Cys Thr Arg  Ala Ala Pro Leu Asp  Ser Ile His 
    2270                 2275                 2280             


Ser Leu  Ala Ala Tyr Tyr Ile  Asp Cys Ile Arg Gln  Val Gln Pro 
    2285                 2290                 2295             


Glu Gly  Pro Tyr Arg Val Ala  Gly Tyr Ser Tyr Gly  Ala Cys Val 
    2300                 2305                 2310             


Ala Phe  Glu Met Cys Ser Gln  Leu Gln Ala Gln Gln  Ser Pro Ala 
    2315                 2320                 2325             


Pro Thr  His Asn Ser Leu Phe  Leu Phe Asp Gly Ser  Pro Thr Tyr 
    2330                 2335                 2340             


Val Leu  Ala Tyr Thr Gln Ser  Tyr Arg Ala Lys Leu  Thr Pro Gly 
    2345                 2350                 2355             


Cys Glu  Ala Glu Ala Glu Thr  Glu Ala Ile Cys Phe  Phe Val Gln 
    2360                 2365                 2370             


Gln Phe  Thr Asp Met Glu His  Asn Arg Val Leu Glu  Ala Leu Leu 
    2375                 2380                 2385             


Pro Leu  Lys Gly Leu Glu Glu  Arg Val Ala Ala Ala  Val Asp Leu 
    2390                 2395                 2400             


Ile Ile  Lys Ser His Gln Gly  Leu Asp Arg Gln Glu  Leu Ser Phe 
    2405                 2410                 2415             


Ala Ala  Arg Ser Phe Tyr Tyr  Lys Leu Arg Ala Ala  Glu Gln Tyr 
    2420                 2425                 2430             


Thr Pro  Lys Ala Lys Tyr His  Gly Asn Val Met Leu  Leu Arg Ala 
    2435                 2440                 2445             


Lys Thr  Gly Gly Ala Tyr Gly  Glu Asp Leu Gly Ala  Asp Tyr Asn 
    2450                 2455                 2460             


Leu Ser  Gln Val Cys Asp Gly  Lys Val Ser Val His  Val Ile Glu 
    2465                 2470                 2475             


Gly Asp  His Arg Thr Leu Leu  Glu Gly Ser Gly Leu  Glu Ser Ile 
    2480                 2485                 2490             


Ile Ser  Ile Ile His Ser Ser  Leu Ala Glu Pro Arg  Val Ser Val 
    2495                 2500                 2505             


Arg Glu  Gly 
    2510     


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  27
ctcagggtag tatgggat                                                     18


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide primer

<400>  28
atcccatact accctgag                                                     18


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  29
caccacactt ggcaatcc                                                     18


<210>  30
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  30
gattgcgtgt ggtgatg                                                      17


<210>  31
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  31
tgactgactg aatcgatg                                                     18


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  32
caggtggggt ctttcatt                                                     18


<210>  33
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  33
atggacgagc tgtacaag                                                     18


<210>  34
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide primer

<400>  34
gtcggatgca actgcaag                                                     18


<210>  35
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic cloning shRNA oligonucleotide

<400>  35
tgctgttgac agtgagcgcc gcttcttaga gattggcaaa tagtgaagcc acagatgtat       60

ttgccaatct ctaagaagcg atgcctactg cctcgg                                 96


<210>  36
<211>  96
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic cloning shRNA oligonucleotide

<400>  36
tgctgttgac agtgagcgcc gcttcttaga gattggcaaa tagtgaagcc acagatgtat       60

ttgccaatct ctaagaagcg atgcctactg cctcgg                                 96


<210>  37
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  37
ggaagaagaa cuauguauua uaugt                                             25


<210>  38
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  38
acauauaaua cauaguucuu cuucccu                                           27


<210>  39
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  39
cuuccucucu uucucucccu ugug                                              24


<210>  40
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  40
ucacaaggga gagaaagaga ggaagga                                           27


<210>  41
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  41
acuaaucagu acuuccauua agcct                                             25


<210>  42
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic siRNA oligonucleotide

<400>  42
aggcuuaaug gaaguacuga uuagucu                                           27


