                         SEQUENCE LISTING

<110>  The Government of The United States of America as 
       Represented by the Secretary, Department of Health and Human 
       Services
       Hearing, Vincent J
       Choi, Wonseon
 
<120>  REGULATION OF SKIN PIGMENTATION BY NEUREGULIN-1 (NRG-1)

<130>  4239-84984-02

<150>  US 61/357,846
<151>  2010-06-23

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide sequence for human ERBB2

<400>  1
acagtggcat ctgtgagctg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide sequence for human ERBB2

<400>  2
agcagaggtg ggtgttatgg                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide sequence for NRG-1

<400>  3
ctgtgtgaat ggaggggagt                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide sequence for NRG-1

<400>  4
gctttttccg ctgtttcttg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide sequence for GADPH

<400>  5
accacagtcc atgccatcac                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide sequence for GADPH

<400>  6
tccaccaccc tgttgctgta                                                   20


<210>  7
<211>  645
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys 
1               5                   10                  15      


Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser 
            20                  25                  30          


Pro Ala Leu Pro Pro Gln Leu Lys Glu Met Lys Ser Gln Glu Ser Ala 
        35                  40                  45              


Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser 
    50                  55                  60                  


Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys 
65                  70                  75                  80  


Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu 
                85                  90                  95      


Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys 
            100                 105                 110         


Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr 
        115                 120                 125             


Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu 
    130                 135                 140                 


Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr 
145                 150                 155                 160 


Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr 
                165                 170                 175     


Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
            180                 185                 190         


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
        195                 200                 205             


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
    210                 215                 220                 


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
225                 230                 235                 240 


Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile 
                245                 250                 255     


Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr 
            260                 265                 270         


Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg 
        275                 280                 285             


Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro 
    290                 295                 300                 


Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys 
305                 310                 315                 320 


Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser 
                325                 330                 335     


Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val 
            340                 345                 350         


Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile 
        355                 360                 365             


Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser 
    370                 375                 380                 


Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr 
385                 390                 395                 400 


Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr 
                405                 410                 415     


Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala 
            420                 425                 430         


Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser 
        435                 440                 445             


Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met 
    450                 455                 460                 


Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu 
465                 470                 475                 480 


Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe 
                485                 490                 495     


Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His 
            500                 505                 510         


Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu 
        515                 520                 525             


Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys 
    530                 535                 540                 


Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His 
545                 550                 555                 560 


Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser 
                565                 570                 575     


Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro 
            580                 585                 590         


Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro 
        595                 600                 605             


Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser 
    610                 615                 620                 


Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln 
625                 630                 635                 640 


Asp Pro Ile Ala Val 
                645 


<210>  8
<211>  3092
<212>  DNA
<213>  Homo sapiens

<400>  8
gaggccaggg gagggtgcga aggaggcgcc tgcctccaac ctgcgggcgg gaggtgggtg       60

gctgcggggc aattgaaaaa gagccggcga ggagttcccc gaaacttgtt ggaactccgg      120

gctcgcgcgg aggccaggag ctgagcggcg gcggctgccg gacgatggga gcgtgagcag      180

gacggtgata acctctcccc gatcgggttg cgagggcgcc gggcagaggc caggacgcga      240

gccgccagcg gtgggaccca tcgacgactt cccggggcga caggagcagc cccgagagcc      300

agggcgagcg cccgttccag gtggccggac cgcccgccgc gtccgcgccg cgctccctgc      360

aggcaacggg agacgccccc gcgcagcgcg agcgcctcag cgcggccgct cgctctcccc      420

ctcgagggac aaacttttcc caaacccgat ccgagccctt ggaccaaact cgcctgcgcc      480

gagagccgtc cgcgtagagc gctccgtctc cggcgagatg tccgagcgca aagaaggcag      540

aggcaaaggg aagggcaaga agaaggagcg aggctccggc aagaagccgg agtccgcggc      600

gggcagccag agcccagcct tgcctccccg attgaaagag atgaaaagcc aggaatcggc      660

tgcaggttcc aaactagtct tcggtgtgaa accagttctg aatactcctc tctcagattc      720

aagtggttca agaatgggaa tgaattgaat cgaaaaaaca aaccacaaaa tatcaagata      780

caaaaaaagc cagggaagtc agaacttcgc attaacaaag catcactggc tgattctgga      840

gagtatatgt gcaaagtgat cagcaaatta ggaaatgaca gtgcctctgc caatatcacc      900

atcgtggaat caaacgagat catcactggt atgccagcct caactgaagg agcatatgtg      960

tcttcagagt ctcccattag aatatcagta tccacagaag gagcaaatac ttcttcatct     1020

acatctacat ccaccactgg gacaagccat cttgtaaaat gtgcggagaa ggagaaaact     1080

ttctgtgtga atggagggga gtgcttcatg gtgaaagacc tttcaaaccc ctcgagatac     1140

ttgtgcaagt gcccaaatga gtttactggt gatcgctgcc aaaactacgt aatggccagc     1200

ttctacaagc atcttgggat tgaatttatg gaggcggagg agctgtacca gaagagagtg     1260

ctgaccataa ccggcatctg catcgccctc cttgtggtcg gcatcatgtg tgtggtggcc     1320

tactgcaaaa ccaagaaaca gcggaaaaag ctgcatgacc gtcttcggca gagccttcgg     1380

tctgaacgaa acaatatgat gaacattgcc aatgggcctc accatcctaa cccacccccc     1440

gagaatgtcc agctggtgaa tcaatacgta tctaaaaacg tcatctccag tgagcatatt     1500

gttgagagag aagcagagac atccttttcc accagtcact atacttccac agcccatcac     1560

tccactactg tcacccagac tcctagccac agctggagca acggacacac tgaaagcatc     1620

ctttccgaaa gccactctgt aatcgtgatg tcatccgtag aaaacagtag gcacagcagc     1680

ccaactgggg gcccaagagg acgtcttaat ggcacaggag gccctcgtga atgtaacagc     1740

ttcctcaggc atgccagaga aacccctgat tcctaccgag actctcctca tagtgaaagg     1800

tatgtgtcag ccatgaccac cccggctcgt atgtcacctg tagatttcca cacgccaagc     1860

tcccccaaat cgcccccttc ggaaatgtct ccacccgtgt ccagcatgac ggtgtccatg     1920

ccttccatgg cggtcagccc cttcatggaa gaagagagac ctctacttct cgtgacacca     1980

ccaaggctgc gggagaagaa gtttgaccat caccctcagc agttcagctc cttccaccac     2040

aaccccgcgc atgacagtaa cagcctccct gctagcccct tgaggatagt ggaggatgag     2100

gagtatgaaa cgacccaaga gtacgagcca gcccaagagc ctgttaagaa actcgccaat     2160

agccggcggg ccaaaagaac caagcccaat ggccacattg ctaacagatt ggaagtggac     2220

agcaacacaa gctcccagag cagtaactca gagagtgaaa cagaagatga aagagtaggt     2280

gaagatacgc ctttcctggg catacagaac cccctggcag ccagtcttga ggcaacacct     2340

gccttccgcc tggctgacag caggactaac ccagcaggcc gcttctcgac acaggaagaa     2400

atccaggcca ggctgtctag tgtaattgct aaccaagacc ctattgctgt ataaaaccta     2460

aataaacaca tagattcacc tgtaaaactt tattttatat aataaagtat tccaccttaa     2520

attaaacaat ttattttatt ttagcagttc tgcaaataga aaacaggaaa aaaactttta     2580

taaattaaat atatgtatgt aaaaatgtgt tatgtgccat atgtagcaat tttttacagt     2640

atttcaaaac gagaaagata tcaatggtgc ctttatgtta tgttatgtcg agagcaagtt     2700

ttgtacagtt acagtgattg cttttccaca gtatttctgc aaaacctctc atagattcag     2760

tttttgctgg cttcttgtgc attgcattat gatgttgact ggatgtatga tttgcaagac     2820

ttgcaactgt ccctctgttt gcttgtagta gcacccgatc agtatgtctt gtaatggcac     2880

atccatccag atatgcctct cttgtgtatg aagttttctt tgctttcaga atatgaaatg     2940

agttgtgtct actctgccag ccaaaggttt gcctcattgg gctctgagat aatagtagat     3000

ccaacagcat gctactatta aatacagcaa gaaactgcat taagtaatgt taaatattag     3060

gaagaaagta atactgtgat ttaaaaaaaa ct                                   3092


<210>  9
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  9

Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
1               5                   10                  15      


Ser Arg Tyr Leu Cys Lys Cys Gln Pro Gly Phe Thr Gly Ala Arg Cys 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  10

Cys Val Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro 
1               5                   10                  15      


Ser Arg Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys 
            20                  25                  30          


<210>  11
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  11

Thr Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val 
1               5                   10                  15      


Asn Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg 
            20                  25                  30          


Tyr Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn 
        35                  40                  45              


Tyr Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu 
    50                  55                  60                  


Ala Glu Glu Leu Tyr Gln Lys 
65                  70      


