                         SEQUENCE LISTING

<110>  Novozymes, Inc.
       Luttringer, Sheryl
       Yaver, Debbie
 
<120>  Methods for Improved C4 Dicarboxylic Acid Production In 
       Filamentous Fungi

<130>  11772-WO-PCT

<150>  US 61/357,007
<151>  2010-06-21

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1179
<212>  DNA
<213>  Aspergillus clavatus

<400>  1
atgttcgaaa atcgtatacc gccgacctcg tctcagtcag actctggctt cctcgagaac       60

cagctggaaa aacaacatcg actcagcctc cgtgagaggt taaggcactt tacctgggcc      120

tggtacacat tgaccatgag cacaggtggg ttggctctcc tgatagcgag ccagccatac      180

accttcaagg ggttgaagac cattggactg gtggtctaca tcgtgaactt gatcttgttt      240

ggtcttgtct gttcccttat ggccactagg ttcatcctcc acggtggctt cctcgactcc      300

cttcgccatg agcgcgaggg tcttttcttt cctaccttct ggctatccgt agcaaccatc      360

atcaccggct tgcatcgcta cttcggctcc gatgctcgag aatcgtacct gattgcactc      420

gaagtactct tctgggtcta ctgtgcctgt acactggcca cagcagtgat ccagtactcc      480

ttcatcttct ctgcgcacag atacggcctc cagaccatga tgccctcctg gattctccca      540

gccttcccca tcatgctcag tggcacgatt gcctccgtca tcggcgaagc tcaacccgca      600

cggtcatcga tccccgtcat catggccgga gtcaccttcc agggcctggg gttctcgatc      660

agcttcatga tgtacgccca ctatatcggc cggctgatgg aatcagggct cccctgccgc      720

gagcacagac ccggcatgtt catctgcgtt ggtcccccgg ctttcacagc cctcgctcta      780

gtcgggatgg ccaagggcct gcccgccgag ttcaagctca tcaacgacgc acacgccctc      840

gaagacgcgc ggatcctcga gctgctcgca atcaccgcgg gcatcttcct ctgggccctg      900

agtctgtggt tcttcttcat cgccgtcatc gccgtcctcc ggtccccgcc tacttccttc      960

catctcaact ggtgggcctt ggtcttcccg aacacgggct tcactttggc caccatcacg     1020

cttggaaagg cattgggcag tcccgggatc ttgggcgttg gttctgccat gtcccttggc     1080

atcgttggca tgtggctgtt tgtttttgtc agccatatcc gtgccatcat caaccaggat     1140

atcatgtatc cgggcaaaga tgaggatgct gcagactag                            1179


<210>  2
<211>  392
<212>  PRT
<213>  Aspergillus clavatus

<400>  2

Met Phe Glu Asn Arg Ile Pro Pro Thr Ser Ser Gln Ser Asp Ser Gly 
1               5                   10                  15      


Phe Leu Glu Asn Gln Leu Glu Lys Gln His Arg Leu Ser Leu Arg Glu 
            20                  25                  30          


Arg Leu Arg His Phe Thr Trp Ala Trp Tyr Thr Leu Thr Met Ser Thr 
        35                  40                  45              


Gly Gly Leu Ala Leu Leu Ile Ala Ser Gln Pro Tyr Thr Phe Lys Gly 
    50                  55                  60                  


Leu Lys Thr Ile Gly Leu Val Val Tyr Ile Val Asn Leu Ile Leu Phe 
65                  70                  75                  80  


Gly Leu Val Cys Ser Leu Met Ala Thr Arg Phe Ile Leu His Gly Gly 
                85                  90                  95      


Phe Leu Asp Ser Leu Arg His Glu Arg Glu Gly Leu Phe Phe Pro Thr 
            100                 105                 110         


Phe Trp Leu Ser Val Ala Thr Ile Ile Thr Gly Leu His Arg Tyr Phe 
        115                 120                 125             


Gly Ser Asp Ala Arg Glu Ser Tyr Leu Ile Ala Leu Glu Val Leu Phe 
    130                 135                 140                 


Trp Val Tyr Cys Ala Cys Thr Leu Ala Thr Ala Val Ile Gln Tyr Ser 
145                 150                 155                 160 


Phe Ile Phe Ser Ala His Arg Tyr Gly Leu Gln Thr Met Met Pro Ser 
                165                 170                 175     


Trp Ile Leu Pro Ala Phe Pro Ile Met Leu Ser Gly Thr Ile Ala Ser 
            180                 185                 190         


Val Ile Gly Glu Ala Gln Pro Ala Arg Ser Ser Ile Pro Val Ile Met 
        195                 200                 205             


Ala Gly Val Thr Phe Gln Gly Leu Gly Phe Ser Ile Ser Phe Met Met 
    210                 215                 220                 


Tyr Ala His Tyr Ile Gly Arg Leu Met Glu Ser Gly Leu Pro Cys Arg 
225                 230                 235                 240 


Glu His Arg Pro Gly Met Phe Ile Cys Val Gly Pro Pro Ala Phe Thr 
                245                 250                 255     


Ala Leu Ala Leu Val Gly Met Ala Lys Gly Leu Pro Ala Glu Phe Lys 
            260                 265                 270         


Leu Ile Asn Asp Ala His Ala Leu Glu Asp Ala Arg Ile Leu Glu Leu 
        275                 280                 285             


Leu Ala Ile Thr Ala Gly Ile Phe Leu Trp Ala Leu Ser Leu Trp Phe 
    290                 295                 300                 


Phe Phe Ile Ala Val Ile Ala Val Leu Arg Ser Pro Pro Thr Ser Phe 
305                 310                 315                 320 


His Leu Asn Trp Trp Ala Leu Val Phe Pro Asn Thr Gly Phe Thr Leu 
                325                 330                 335     


Ala Thr Ile Thr Leu Gly Lys Ala Leu Gly Ser Pro Gly Ile Leu Gly 
            340                 345                 350         


Val Gly Ser Ala Met Ser Leu Gly Ile Val Gly Met Trp Leu Phe Val 
        355                 360                 365             


Phe Val Ser His Ile Arg Ala Ile Ile Asn Gln Asp Ile Met Tyr Pro 
    370                 375                 380                 


Gly Lys Asp Glu Asp Ala Ala Asp 
385                 390         


<210>  3
<211>  1182
<212>  DNA
<213>  Aspergillus fumigatus

<400>  3
atgttcaacg atcatgatca tgttccacca acatcatcac agtcggattc tggctttttt       60

gaacaagaaa tgaagaaatc tcctcgacta agccttcgtg agcgcctacg gcacttcacc      120

tgggcgtggt ataccttgac gatgagtacc ggtggactgg ctcttctgat tgctagtcag      180

ccgtatacct tcaatggcat gaagggcatc gggatggtcg tttatatcct caatcttctg      240

ttattcgctc ttgtctgttc tttgatggtg ctgagattcg ttttgcatgg cggtttcctt      300

gacagcttgc gccaccctcg cgagggtctc ttcttcccta ccttctggct atccattgca      360

acgatcatca ctggcttgca tcgttacttc ggctccgacg acctagagtc gtacctcatc      420

gcactcgaag tcctcttctg ggtctactgt agttgcaccc tcgccacagc tgtgatccag      480

tactcattcc tctttgccgc ccactcctac ggcctgcaga caatgatgcc atcatggatc      540

ctaccagcct tccccatcat gctcagcgga accatcgcct cggtcatcag cgaatcccag      600

cccgcgcgat ccgcgatccc catcatcact gccggcgtta ccttccaggg cctcggcttc      660

tcaatcagct tcataatgta cgcccactac atcggccgac tcatgcagtc agggcttccc      720

tgccgcgaac acagaccagc catgttcatt tgcgtggggc ctccgtcttt caccgcgttg      780

gcgctagtag ggatggccaa gggcctgccc gacgaattca agataatcaa agacgcacac      840

gtcgaggacg cccggatcct cgagctgatg gctattatcg tcggcgtgtt cctgtgggcc      900

ctgagtctct ggttcttctt cattgccttt gttgctgtcg tccggtgccg gcccactgcg      960

ttccacctta gctggtgggc catggtcttc cccaacactg ggttcacgct ggccactatt     1020

accctgggga gggcattggg gagccctggc gtcttgggcg tcggctcggc catgtcggtc     1080

ggtgttgtct gcatgtgggt cttcgttttc gtctaccaca ttcgtgctgt catcaggcaa     1140

gacatcatgt acccgggcaa agacgaggat gtgctagatt aa                        1182


<210>  4
<211>  393
<212>  PRT
<213>  Aspergillus fumigatus

<400>  4

Met Phe Asn Asp His Asp His Val Pro Pro Thr Ser Ser Gln Ser Asp 
1               5                   10                  15      


Ser Gly Phe Phe Glu Gln Glu Met Lys Lys Ser Pro Arg Leu Ser Leu 
            20                  25                  30          


Arg Glu Arg Leu Arg His Phe Thr Trp Ala Trp Tyr Thr Leu Thr Met 
        35                  40                  45              


Ser Thr Gly Gly Leu Ala Leu Leu Ile Ala Ser Gln Pro Tyr Thr Phe 
    50                  55                  60                  


Asn Gly Met Lys Gly Ile Gly Met Val Val Tyr Ile Leu Asn Leu Leu 
65                  70                  75                  80  


Leu Phe Ala Leu Val Cys Ser Leu Met Val Leu Arg Phe Val Leu His 
                85                  90                  95      


Gly Gly Phe Leu Asp Ser Leu Arg His Pro Arg Glu Gly Leu Phe Phe 
            100                 105                 110         


Pro Thr Phe Trp Leu Ser Ile Ala Thr Ile Ile Thr Gly Leu His Arg 
        115                 120                 125             


Tyr Phe Gly Ser Asp Asp Leu Glu Ser Tyr Leu Ile Ala Leu Glu Val 
    130                 135                 140                 


Leu Phe Trp Val Tyr Cys Ser Cys Thr Leu Ala Thr Ala Val Ile Gln 
145                 150                 155                 160 


Tyr Ser Phe Leu Phe Ala Ala His Ser Tyr Gly Leu Gln Thr Met Met 
                165                 170                 175     


Pro Ser Trp Ile Leu Pro Ala Phe Pro Ile Met Leu Ser Gly Thr Ile 
            180                 185                 190         


Ala Ser Val Ile Ser Glu Ser Gln Pro Ala Arg Ser Ala Ile Pro Ile 
        195                 200                 205             


Ile Thr Ala Gly Val Thr Phe Gln Gly Leu Gly Phe Ser Ile Ser Phe 
    210                 215                 220                 


Ile Met Tyr Ala His Tyr Ile Gly Arg Leu Met Gln Ser Gly Leu Pro 
225                 230                 235                 240 


Cys Arg Glu His Arg Pro Ala Met Phe Ile Cys Val Gly Pro Pro Ser 
                245                 250                 255     


Phe Thr Ala Leu Ala Leu Val Gly Met Ala Lys Gly Leu Pro Asp Glu 
            260                 265                 270         


Phe Lys Ile Ile Lys Asp Ala His Val Glu Asp Ala Arg Ile Leu Glu 
        275                 280                 285             


Leu Met Ala Ile Ile Val Gly Val Phe Leu Trp Ala Leu Ser Leu Trp 
    290                 295                 300                 


Phe Phe Phe Ile Ala Phe Val Ala Val Val Arg Cys Arg Pro Thr Ala 
305                 310                 315                 320 


Phe His Leu Ser Trp Trp Ala Met Val Phe Pro Asn Thr Gly Phe Thr 
                325                 330                 335     


Leu Ala Thr Ile Thr Leu Gly Arg Ala Leu Gly Ser Pro Gly Val Leu 
            340                 345                 350         


Gly Val Gly Ser Ala Met Ser Val Gly Val Val Cys Met Trp Val Phe 
        355                 360                 365             


Val Phe Val Tyr His Ile Arg Ala Val Ile Arg Gln Asp Ile Met Tyr 
    370                 375                 380                 


Pro Gly Lys Asp Glu Asp Val Leu Asp 
385                 390             


<210>  5
<211>  36
<212>  DNA
<213>  Aspergillus clavatus

<400>  5
gtgtgataga acatcgtcca taatgttcga aaatcg                                 36


<210>  6
<211>  44
<212>  DNA
<213>  Aspergillus clavatus

<400>  6
gtcagtcacc tctagttaat taactagtct gcagcatcct catc                        44


<210>  7
<211>  25
<212>  DNA
<213>  Aspergillus clavatus

<400>  7
ctatagcgaa atggattgat tgtct                                             25


<210>  8
<211>  20
<212>  DNA
<213>  Aspergillus clavatus

<400>  8
tgaccttcca cgctgaccac                                                   20


<210>  9
<211>  42
<212>  DNA
<213>  Aspergillus fumigates

<400>  9
gtgtgataga acatcgtcca taatgttcaa cgatcatgat ca                          42


<210>  10
<211>  44
<212>  DNA
<213>  Aspergillus fumigates

<400>  10
gtcagtcacc tctagttaat taattaatct agcacatcct cgtc                        44


<210>  11
<211>  1430
<212>  DNA
<213>  Aspergillus oryzae

<400>  11
atggtcaaag ctggtgagtt agcaatcctt aacagatgac actctcatag gtactaactc       60

gaaacgttag cggtacttgg agcttctggt ggcattggcc aggtatggat atccccacgc      120

cttacaaccc tggtcacaat atgaccttgt tcgatactga ctatctccca agccactgtc      180

tctcctgttg aagacctgtc ccttagttga agagcttgct ctctacgatg ttgtgaacac      240

ccctggtgtt gctgctgatc tatcccacat ctcgtctatc gctgtacgtt actgccacaa      300

tgcgaattgc ccgatggaag aggcgaaaaa tggtatcttg cttacctggg cgattagaaa      360

atctctggtt ttctgcccaa agatgatggg ctgaagcagg cccttactgg tgctaatatt      420

gttgtcatcc cggctggtat tccccgtaag tccctaccct ttcgcattgc tcctcgtatg      480

ttcgctggtg gccagttttc tgatagttga taggcaagcc tggtatgacc cgtgacgacc      540

tcttcaagat caacgccggc atagtgcgag acttggtcaa gggtatcgcc gagttctgcc      600

ccaaggcctt tgttctggtt atctcaaacc ccgttaattc tactgttcct attgctgcag      660

aggtgctcaa agccgctggc gtctttgacc cgaagcgcct ctttggtgtc accacactgg      720

acgtcgttcg tgcagagact ttcacccaag agttctcggg ccagaaggat ccttctgctg      780

ttcaaatccc agttgttggt ggccactctg gagagaccat tgtccccctc ttcagcaaga      840

ctacccccgc aattcagata cccgaggaga agtatgacgc actgatccac cgtaggttgt      900

cccaaagaat ctcatgaata tcttgctgta agcactaact atgcttcagg cgtccaattt      960

ggtggagatg aggtggtcca agctaaggac ggtgctggtt ccgccacctt gtctatggcc     1020

tatgccggtt acaggtaggg atgctgcgta ccgtgagagc actcgcggct aacatgccat     1080

aggttcgctg agagtgtaat caaagcttca aagggtcaaa cgggtattgt cgagcctacc     1140

ttcgtctacc tgcctggaat tcccggcggt gatgagatcg ttaaggcaac tggcgtggaa     1200

ttcttctcta ctcttgtaac cttaggagta agattcatct cctcacagaa tcttcgttca     1260

tatcacgcca ggctaacgct attaaacaga ctaatggcgc agagaaggct agcaacgttc     1320

ttgagggcgt gaccgagaag gaaaagaagc ttctcgaggc ttgcacgaaa ggccttaagg     1380

gtaatatcga gaaaggcatc gacttcgtta agaacccacc accaaagtaa                1430


<210>  12
<211>  330
<212>  PRT
<213>  Aspergillus oryzae

<400>  12

Met Val Lys Ala Ala Val Leu Gly Ala Ser Gly Gly Ile Gly Gln Pro 
1               5                   10                  15      


Leu Ser Leu Leu Leu Lys Thr Cys Pro Leu Val Glu Glu Leu Ala Leu 
            20                  25                  30          


Tyr Asp Val Val Asn Thr Pro Gly Val Ala Ala Asp Leu Ser His Ile 
        35                  40                  45              


Ser Ser Ile Ala Lys Ile Ser Gly Phe Leu Pro Lys Asp Asp Gly Leu 
    50                  55                  60                  


Lys Gln Ala Leu Thr Gly Ala Asn Ile Val Val Ile Pro Ala Gly Ile 
65                  70                  75                  80  


Pro Arg Lys Pro Gly Met Thr Arg Asp Asp Leu Phe Lys Ile Asn Ala 
                85                  90                  95      


Gly Ile Val Arg Asp Leu Val Lys Gly Ile Ala Glu Phe Cys Pro Lys 
            100                 105                 110         


Ala Phe Val Leu Val Ile Ser Asn Pro Val Asn Ser Thr Val Pro Ile 
        115                 120                 125             


Ala Ala Glu Val Leu Lys Ala Ala Gly Val Phe Asp Pro Lys Arg Leu 
    130                 135                 140                 


Phe Gly Val Thr Thr Leu Asp Val Val Arg Ala Glu Thr Phe Thr Gln 
145                 150                 155                 160 


Glu Phe Ser Gly Gln Lys Asp Pro Ser Ala Val Gln Ile Pro Val Val 
                165                 170                 175     


Gly Gly His Ser Gly Glu Thr Ile Val Pro Leu Phe Ser Lys Thr Thr 
            180                 185                 190         


Pro Ala Ile Gln Ile Pro Glu Glu Lys Tyr Asp Ala Leu Ile His Arg 
        195                 200                 205             


Val Gln Phe Gly Gly Asp Glu Val Val Gln Ala Lys Asp Gly Ala Gly 
    210                 215                 220                 


Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Tyr Arg Phe Ala Glu Ser 
225                 230                 235                 240 


Val Ile Lys Ala Ser Lys Gly Gln Thr Gly Ile Val Glu Pro Thr Phe 
                245                 250                 255     


Val Tyr Leu Pro Gly Ile Pro Gly Gly Asp Glu Ile Val Lys Ala Thr 
            260                 265                 270         


Gly Val Glu Phe Phe Ser Thr Leu Val Thr Leu Gly Thr Asn Gly Ala 
        275                 280                 285             


Glu Lys Ala Ser Asn Val Leu Glu Gly Val Thr Glu Lys Glu Lys Lys 
    290                 295                 300                 


Leu Leu Glu Ala Cys Thr Lys Gly Leu Lys Gly Asn Ile Glu Lys Gly 
305                 310                 315                 320 


Ile Asp Phe Val Lys Asn Pro Pro Pro Lys 
                325                 330 


<210>  13
<211>  3643
<212>  DNA
<213>  Aspergillus oryzae

<400>  13
atggcggctc cgtttcgtca gcctgaggag gcggtcgatg acaccgagtt catcgatgac       60

caccatgaac acctccgtga taccgtgcac catcggttgc gcgccaattc ctccattatg      120

cacttccaga agatcctcgt cgccaaccgt ggtgagatcc ccattcgtat cttcagaacg      180

gcccacgagc tgtcattgca gacggttgct atctactctc atgaggatcg actgtcaatg      240

caccgtcaaa aggccgatga ggcctacatg attggccacc gcggtcagta cacccctgtc      300

ggtgcgtacc tggcgggcga tgagatcatc aagatcgccc tggagcacgg tgtccagctg      360

atccacccgg gctacggttt cttgtccgag aacgccgact tcgcccgcaa ggttgagaac      420

gccggcattg tctttgtggg acccactccc gataccattg acagcttggg tgacaaggtg      480

tcggcccgtc ggctggccat taagtgcgag gtccctgtcg ttccgggtac ggagggcccc      540

gtcgagcgct atgaggaggt caaggcgttc acagacacct atggcttccc catcatcatc      600

aaggctgcct ttggcggtgg tggccgtggt atgcgtgtgg tccgtgacca ggccgagctg      660

cgtgactcgt tcgagcgagc cacctctgag gcccgctccg ccttcggcaa tggtaccgtc      720

ttcgtcgagc gcttcctcga caaacccaag cacattgaag tccagcttct gggtgacagc      780

cacggcaacg ttgtccatct gtttgagcgt gactgctccg tgcagcgtcg tcaccagaag      840

gtcgttgagg ttgctccggc taaggacctg ccagccgatg tccgggaccg catcctggcc      900

gatgctgtga agctggccaa gtccgtcaac taccgtaacg ccggtacagc tgagttcctg      960

gtggaccagc agaaccgcca ctacttcatt gaaatcaatc ctcgtatcca agtcgagcac     1020

accatcaccg aagagattac tggtatcgat atcgtggctg cacagatcca gattgctgct     1080

ggtgcaagcc tcgagcaact gggcctgact caggaccgca tctccgcccg cggatttgcc     1140

attcaatgtc gtatcaccac ggaagatccc gccaaggggt tctctccgga tactggtaag     1200

attgaggttt atcgttccgc tggtggtaac ggtgtccgtc tggatggtgg taacggtttc     1260

gctggtgcta tcatcacccc tcactacgac tccatgctgg tcaagtgtac ctgccgtggt     1320

tcgacctatg aaatcgctcg tcgcaaggtt gtgcgtgcct tggtcgagtt ccgtattcgt     1380

ggtgtgaaga ccaacattcc cttcctgact tcgcttctga gccacccgac cttcgtcgat     1440

ggaaactgct ggaccacttt catcgacgac acccctgaat tgttctctct tgtcggcagt     1500

cagaaccgtg cccagaagct gctcgcatac ctcggcgatg tagctgtcaa cggtagtagc     1560

atcaagggcc aaattggcga gcccaagctc aagggtgatg tcatcaagcc gaagcttttc     1620

gatgccgagg gcaagccgct tgacgtttcc gccccctgca ccaagggttg gaagcagatt     1680

ctggaccggg agggcccggc tgcctttgcg aaggccgtgc gtgccaacaa gggttgcttg     1740

atcatggata ctacctggcg tgacgcccac cagtctttgc tggccacccg tgtgcgtacc     1800

atcgacttgt tgaacatcgc ccatgagacc agctacgcct actccaatgc gtacagtttg     1860

gaatgctggg gtggtgctac cttcgatgtg gccatgcgtt tcctctatga ggacccctgg     1920

gaccgcctgc gcaagatgcg taaggctgtt cctaacatcc cattccagat gttgctccgt     1980

ggtgccaacg gtgtcgccta ctcttccctc ccagacaacg ccatctacca cttctgtaag     2040

caggctaaga agtgcggtgt cgacattttc cgtgttttcg acgccctcaa cgatgtcgat     2100

cagctcgagg tcggtatcaa ggctgttcat gctgccgagg gtgttgtcga ggccaccatg     2160

tgctacagcg gtgacatgct gaacccccac aagaagtaca acctggagta ctacatggcc     2220

ttggtggata agattgtagc catgaagcct cacatccttg gtatcaagga tatggccggt     2280

gtgctgaagc cccaggccgc tcgcctgttg gtgggctcca tccgtcagcg ctaccctgac     2340

cttcccatcc acgtccacac ccacgactcc gctggtactg gtgtagcttc catgattgcc     2400

tgtgcccagg cgggtgccga cgccgtggac gccgcgaccg acagcatgtc cggtatgacc     2460

tcccagccta gcattggtgc cattctggcc tctcttgagg gcactgagca agaccccggt     2520

ctcaacctcg cccacgtgcg cgctattgat agctactggg cacagctgcg cttgctctac     2580

tctcctttcg aggcgggtct cactggcccc gaccctgagg tctacgagca cgagatccct     2640

ggtggtcagt tgaccaacct tatcttccag gccagtcagc tcggcttggg ccagcagtgg     2700

gccgaaacca agaaggccta tgaggcggct aatgatttac tcggcgacat tgtaaaggtc     2760

actcccacct ccaaggtggt cggtgacttg gctcagttca tggtctcgaa caaactgact     2820

ccggaggatg ttgttgagcg tgctggtgag ctggacttcc ctggttctgt gctcgaattc     2880

ctcgaaggtc tcatgggaca gcccttcggt ggattccccg agccattgcg ctcccgcgcc     2940

ctgcgcgatc gccgcaagct cgagaagcgt ccaggtctct acctcgagcc tttggatttg     3000

gctaagatca agagccagat ccgtgagaag ttcggtgctg ctactgagta tgacgtggcc     3060

agctatgcca tgtatcccaa ggtcttcgag gactacaaga agttcgtcca gaagttcggt     3120

gatctctccg tcttgcccac acggtacttc ttggccaagc ctgagattgg cgaggagttc     3180

cacgttgagc tggagaaggg taaggtgctc atcctgaagt tgttggccat cggccctctt     3240

tcagagcaga ctggtcagcg tgaggtcttc tacgaagtca acggtgaggt gcgccaggtc     3300

gctgttgatg acaacaaggc ttccgtggac aacacttcac gccctaaggc cgatgtgggt     3360

gacagcagcc aggtcggtgc tcctatgagc ggtgtggttg ttgaaatccg tgtccacgat     3420

ggtctggagg ttaagaaggg tgacccactt gccgtcctga gtgccatgaa gatggtaagt     3480

tcattccgaa tcatttttct cactggtcaa ctacagatgc taacagctta tccaggaaat     3540

ggttatctct gctcctcaca gtggaaaggt ctccagcttg ctggtcaagg agggcgattc     3600

tgtggatggc caggatctcg tctgcaagat cgtcaaagcg taa                       3643


<210>  14
<211>  1193
<212>  PRT
<213>  Aspergillus oryzae

<400>  14

Met Ala Ala Pro Phe Arg Gln Pro Glu Glu Ala Val Asp Asp Thr Glu 
1               5                   10                  15      


Phe Ile Asp Asp His His Glu His Leu Arg Asp Thr Val His His Arg 
            20                  25                  30          


Leu Arg Ala Asn Ser Ser Ile Met His Phe Gln Lys Ile Leu Val Ala 
        35                  40                  45              


Asn Arg Gly Glu Ile Pro Ile Arg Ile Phe Arg Thr Ala His Glu Leu 
    50                  55                  60                  


Ser Leu Gln Thr Val Ala Ile Tyr Ser His Glu Asp Arg Leu Ser Met 
65                  70                  75                  80  


His Arg Gln Lys Ala Asp Glu Ala Tyr Met Ile Gly His Arg Gly Gln 
                85                  90                  95      


Tyr Thr Pro Val Gly Ala Tyr Leu Ala Gly Asp Glu Ile Ile Lys Ile 
            100                 105                 110         


Ala Leu Glu His Gly Val Gln Leu Ile His Pro Gly Tyr Gly Phe Leu 
        115                 120                 125             


Ser Glu Asn Ala Asp Phe Ala Arg Lys Val Glu Asn Ala Gly Ile Val 
    130                 135                 140                 


Phe Val Gly Pro Thr Pro Asp Thr Ile Asp Ser Leu Gly Asp Lys Val 
145                 150                 155                 160 


Ser Ala Arg Arg Leu Ala Ile Lys Cys Glu Val Pro Val Val Pro Gly 
                165                 170                 175     


Thr Glu Gly Pro Val Glu Arg Tyr Glu Glu Val Lys Ala Phe Thr Asp 
            180                 185                 190         


Thr Tyr Gly Phe Pro Ile Ile Ile Lys Ala Ala Phe Gly Gly Gly Gly 
        195                 200                 205             


Arg Gly Met Arg Val Val Arg Asp Gln Ala Glu Leu Arg Asp Ser Phe 
    210                 215                 220                 


Glu Arg Ala Thr Ser Glu Ala Arg Ser Ala Phe Gly Asn Gly Thr Val 
225                 230                 235                 240 


Phe Val Glu Arg Phe Leu Asp Lys Pro Lys His Ile Glu Val Gln Leu 
                245                 250                 255     


Leu Gly Asp Ser His Gly Asn Val Val His Leu Phe Glu Arg Asp Cys 
            260                 265                 270         


Ser Val Gln Arg Arg His Gln Lys Val Val Glu Val Ala Pro Ala Lys 
        275                 280                 285             


Asp Leu Pro Ala Asp Val Arg Asp Arg Ile Leu Ala Asp Ala Val Lys 
    290                 295                 300                 


Leu Ala Lys Ser Val Asn Tyr Arg Asn Ala Gly Thr Ala Glu Phe Leu 
305                 310                 315                 320 


Val Asp Gln Gln Asn Arg His Tyr Phe Ile Glu Ile Asn Pro Arg Ile 
                325                 330                 335     


Gln Val Glu His Thr Ile Thr Glu Glu Ile Thr Gly Ile Asp Ile Val 
            340                 345                 350         


Ala Ala Gln Ile Gln Ile Ala Ala Gly Ala Ser Leu Glu Gln Leu Gly 
        355                 360                 365             


Leu Thr Gln Asp Arg Ile Ser Ala Arg Gly Phe Ala Ile Gln Cys Arg 
    370                 375                 380                 


Ile Thr Thr Glu Asp Pro Ala Lys Gly Phe Ser Pro Asp Thr Gly Lys 
385                 390                 395                 400 


Ile Glu Val Tyr Arg Ser Ala Gly Gly Asn Gly Val Arg Leu Asp Gly 
                405                 410                 415     


Gly Asn Gly Phe Ala Gly Ala Ile Ile Thr Pro His Tyr Asp Ser Met 
            420                 425                 430         


Leu Val Lys Cys Thr Cys Arg Gly Ser Thr Tyr Glu Ile Ala Arg Arg 
        435                 440                 445             


Lys Val Val Arg Ala Leu Val Glu Phe Arg Ile Arg Gly Val Lys Thr 
    450                 455                 460                 


Asn Ile Pro Phe Leu Thr Ser Leu Leu Ser His Pro Thr Phe Val Asp 
465                 470                 475                 480 


Gly Asn Cys Trp Thr Thr Phe Ile Asp Asp Thr Pro Glu Leu Phe Ser 
                485                 490                 495     


Leu Val Gly Ser Gln Asn Arg Ala Gln Lys Leu Leu Ala Tyr Leu Gly 
            500                 505                 510         


Asp Val Ala Val Asn Gly Ser Ser Ile Lys Gly Gln Ile Gly Glu Pro 
        515                 520                 525             


Lys Leu Lys Gly Asp Val Ile Lys Pro Lys Leu Phe Asp Ala Glu Gly 
    530                 535                 540                 


Lys Pro Leu Asp Val Ser Ala Pro Cys Thr Lys Gly Trp Lys Gln Ile 
545                 550                 555                 560 


Leu Asp Arg Glu Gly Pro Ala Ala Phe Ala Lys Ala Val Arg Ala Asn 
                565                 570                 575     


Lys Gly Cys Leu Ile Met Asp Thr Thr Trp Arg Asp Ala His Gln Ser 
            580                 585                 590         


Leu Leu Ala Thr Arg Val Arg Thr Ile Asp Leu Leu Asn Ile Ala His 
        595                 600                 605             


Glu Thr Ser Tyr Ala Tyr Ser Asn Ala Tyr Ser Leu Glu Cys Trp Gly 
    610                 615                 620                 


Gly Ala Thr Phe Asp Val Ala Met Arg Phe Leu Tyr Glu Asp Pro Trp 
625                 630                 635                 640 


Asp Arg Leu Arg Lys Met Arg Lys Ala Val Pro Asn Ile Pro Phe Gln 
                645                 650                 655     


Met Leu Leu Arg Gly Ala Asn Gly Val Ala Tyr Ser Ser Leu Pro Asp 
            660                 665                 670         


Asn Ala Ile Tyr His Phe Cys Lys Gln Ala Lys Lys Cys Gly Val Asp 
        675                 680                 685             


Ile Phe Arg Val Phe Asp Ala Leu Asn Asp Val Asp Gln Leu Glu Val 
    690                 695                 700                 


Gly Ile Lys Ala Val His Ala Ala Glu Gly Val Val Glu Ala Thr Met 
705                 710                 715                 720 


Cys Tyr Ser Gly Asp Met Leu Asn Pro His Lys Lys Tyr Asn Leu Glu 
                725                 730                 735     


Tyr Tyr Met Ala Leu Val Asp Lys Ile Val Ala Met Lys Pro His Ile 
            740                 745                 750         


Leu Gly Ile Lys Asp Met Ala Gly Val Leu Lys Pro Gln Ala Ala Arg 
        755                 760                 765             


Leu Leu Val Gly Ser Ile Arg Gln Arg Tyr Pro Asp Leu Pro Ile His 
    770                 775                 780                 


Val His Thr His Asp Ser Ala Gly Thr Gly Val Ala Ser Met Ile Ala 
785                 790                 795                 800 


Cys Ala Gln Ala Gly Ala Asp Ala Val Asp Ala Ala Thr Asp Ser Met 
                805                 810                 815     


Ser Gly Met Thr Ser Gln Pro Ser Ile Gly Ala Ile Leu Ala Ser Leu 
            820                 825                 830         


Glu Gly Thr Glu Gln Asp Pro Gly Leu Asn Leu Ala His Val Arg Ala 
        835                 840                 845             


Ile Asp Ser Tyr Trp Ala Gln Leu Arg Leu Leu Tyr Ser Pro Phe Glu 
    850                 855                 860                 


Ala Gly Leu Thr Gly Pro Asp Pro Glu Val Tyr Glu His Glu Ile Pro 
865                 870                 875                 880 


Gly Gly Gln Leu Thr Asn Leu Ile Phe Gln Ala Ser Gln Leu Gly Leu 
                885                 890                 895     


Gly Gln Gln Trp Ala Glu Thr Lys Lys Ala Tyr Glu Ala Ala Asn Asp 
            900                 905                 910         


Leu Leu Gly Asp Ile Val Lys Val Thr Pro Thr Ser Lys Val Val Gly 
        915                 920                 925             


Asp Leu Ala Gln Phe Met Val Ser Asn Lys Leu Thr Pro Glu Asp Val 
    930                 935                 940                 


Val Glu Arg Ala Gly Glu Leu Asp Phe Pro Gly Ser Val Leu Glu Phe 
945                 950                 955                 960 


Leu Glu Gly Leu Met Gly Gln Pro Phe Gly Gly Phe Pro Glu Pro Leu 
                965                 970                 975     


Arg Ser Arg Ala Leu Arg Asp Arg Arg Lys Leu Glu Lys Arg Pro Gly 
            980                 985                 990         


Leu Tyr Leu Glu Pro Leu Asp Leu  Ala Lys Ile Lys Ser  Gln Ile Arg 
        995                 1000                 1005             


Glu Lys  Phe Gly Ala Ala Thr  Glu Tyr Asp Val Ala  Ser Tyr Ala 
    1010                 1015                 1020             


Met Tyr  Pro Lys Val Phe Glu  Asp Tyr Lys Lys Phe  Val Gln Lys 
    1025                 1030                 1035             


Phe Gly  Asp Leu Ser Val Leu  Pro Thr Arg Tyr Phe  Leu Ala Lys 
    1040                 1045                 1050             


Pro Glu  Ile Gly Glu Glu Phe  His Val Glu Leu Glu  Lys Gly Lys 
    1055                 1060                 1065             


Val Leu  Ile Leu Lys Leu Leu  Ala Ile Gly Pro Leu  Ser Glu Gln 
    1070                 1075                 1080             


Thr Gly  Gln Arg Glu Val Phe  Tyr Glu Val Asn Gly  Glu Val Arg 
    1085                 1090                 1095             


Gln Val  Ala Val Asp Asp Asn  Lys Ala Ser Val Asp  Asn Thr Ser 
    1100                 1105                 1110             


Arg Pro  Lys Ala Asp Val Gly  Asp Ser Ser Gln Val  Gly Ala Pro 
    1115                 1120                 1125             


Met Ser  Gly Val Val Val Glu  Ile Arg Val His Asp  Gly Leu Glu 
    1130                 1135                 1140             


Val Lys  Lys Gly Asp Pro Leu  Ala Val Leu Ser Ala  Met Lys Met 
    1145                 1150                 1155             


Glu Met  Val Ile Ser Ala Pro  His Ser Gly Lys Val  Ser Ser Leu 
    1160                 1165                 1170             


Leu Val  Lys Glu Gly Asp Ser  Val Asp Gly Gln Asp  Leu Val Cys 
    1175                 1180                 1185             


Lys Ile  Val Lys Ala 
    1190             


<210>  15
<211>  1294
<212>  DNA
<213>  Aspergillus oryzae

<400>  15
atgttcgctg ctcgccagtc tttcaacctc ctccagaagc gcgccttctc cgcctctgcc       60

agccaggtgt gtgattgaat ggatccattg gacctcggag ctagctctgc aacatcaaca      120

aaactaacat actaacttat cttcttcata ggcttccaag gttgccgttc ttggtgccgc      180

tggtggcatt ggccagcctc tctcccttct cctcaagctc aacccccgtg tttctgagct      240

tgccctctac gatatccgcg gtggccctgg tatgtttttg cacagcttgc aacatctccg      300

acttcggtga ttcaagacag ggctaacata aggatacaat aggtgttgcc gctgacctga      360

gccacatcaa caccaacagc accgtctctg gctacgaggc taccccctct ggcctccgtg      420

atgctctcaa gggctccgag atcgtcctca tccctgccgg tgttcctcgc aagcccggca      480

tgacccgtga cggtatgaac cgttaacttg tcaatggcac tgggaattga atactaatta      540

taatatcgcc agacctgttc aacaccaacg cctccattgt ccgcgacctt gctaaggccg      600

ccgccgaggc ttcccccgag gccaacatcc tcgtcatctc caaccctgta tgacgctttc      660

cacccactgc taccagttat ctcgcgctaa ttgcaatcag gtcaactcca ccgtccccat      720

cgtctctgag gtcttcaagt ccaagggtgt ctacaacccc aagcgtctct tcggtgtcac      780

tacccttgac gttgtccgtg cctctcgctt catctcccag gtccagaaga ccgacccctc      840

caacgaggcc gtcactgtcg tcggtggtca ctccggtgtg accattgtcc ctcttctctc      900

ccagtccagc caccccagca ttgagggtaa gacccgcgat gagctcgtca accgcatcca      960

gttcggtggt gatgaggttg tcaaggccaa ggatggtgct ggctctgcca ccctctccat     1020

ggccatggct ggtgctcgca tggctgagtc cctcctgaag gccgcccagg gtgagaaggg     1080

tgtcgttgag cccactttcg tcgacagccc tctctacaag gaccagggtg ttgacttctt     1140

cgcctccaag gtcgagctcg gccccaacgg tgttgagaag atcctccccg ttggccaggt     1200

caacgcctac gaggagaagc tcctcgaggc ctgccttggt gacctcaaga agaacatcca     1260

gaagggtatt gacttcgtca aggccaaccc ttaa                                 1294


<210>  16
<211>  340
<212>  PRT
<213>  Aspergillus oryzae

<400>  16

Met Phe Ala Ala Arg Gln Ser Phe Asn Leu Leu Gln Lys Arg Ala Phe 
1               5                   10                  15      


Ser Ala Ser Ala Ser Gln Ala Ser Lys Val Ala Val Leu Gly Ala Ala 
            20                  25                  30          


Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Leu Asn Pro Arg 
        35                  40                  45              


Val Ser Glu Leu Ala Leu Tyr Asp Ile Arg Gly Gly Pro Gly Val Ala 
    50                  55                  60                  


Ala Asp Leu Ser His Ile Asn Thr Asn Ser Thr Val Ser Gly Tyr Glu 
65                  70                  75                  80  


Ala Thr Pro Ser Gly Leu Arg Asp Ala Leu Lys Gly Ser Glu Ile Val 
                85                  90                  95      


Leu Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
            100                 105                 110         


Leu Phe Asn Thr Asn Ala Ser Ile Val Arg Asp Leu Ala Lys Ala Ala 
        115                 120                 125             


Ala Glu Ala Ser Pro Glu Ala Asn Ile Leu Val Ile Ser Asn Pro Val 
    130                 135                 140                 


Asn Ser Thr Val Pro Ile Val Ser Glu Val Phe Lys Ser Lys Gly Val 
145                 150                 155                 160 


Tyr Asn Pro Lys Arg Leu Phe Gly Val Thr Thr Leu Asp Val Val Arg 
                165                 170                 175     


Ala Ser Arg Phe Ile Ser Gln Val Gln Lys Thr Asp Pro Ser Asn Glu 
            180                 185                 190         


Ala Val Thr Val Val Gly Gly His Ser Gly Val Thr Ile Val Pro Leu 
        195                 200                 205             


Leu Ser Gln Ser Ser His Pro Ser Ile Glu Gly Lys Thr Arg Asp Glu 
    210                 215                 220                 


Leu Val Asn Arg Ile Gln Phe Gly Gly Asp Glu Val Val Lys Ala Lys 
225                 230                 235                 240 


Asp Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Met Ala Gly Ala Arg 
                245                 250                 255     


Met Ala Glu Ser Leu Leu Lys Ala Ala Gln Gly Glu Lys Gly Val Val 
            260                 265                 270         


Glu Pro Thr Phe Val Asp Ser Pro Leu Tyr Lys Asp Gln Gly Val Asp 
        275                 280                 285             


Phe Phe Ala Ser Lys Val Glu Leu Gly Pro Asn Gly Val Glu Lys Ile 
    290                 295                 300                 


Leu Pro Val Gly Gln Val Asn Ala Tyr Glu Glu Lys Leu Leu Glu Ala 
305                 310                 315                 320 


Cys Leu Gly Asp Leu Lys Lys Asn Ile Gln Lys Gly Ile Asp Phe Val 
                325                 330                 335     


Lys Ala Asn Pro 
            340 


