                         SEQUENCE LISTING

<110>  AlphaBeta AB
 
<120>  Compound and method for treatment of Alzheimer's disease and 
       familial dementia

<130>  PC-21046645

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys 
1               5                   10                  15      


Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp 
            20                  25                  30          


Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly 
        35                  40                  45              


Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met 
    50                  55                  60                  


Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile Lys Asp 
                85                  90                  95      


Asp Val Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala Leu Tyr 
            100                 105                 110         


Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu 
        115                 120                 125             


Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn 
    130                 135                 140                 


Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn 
145                 150                 155                 160 


Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro 
                165                 170                 175     


Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr 
            180                 185                 190         


Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg 
        195                 200                 205             


Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His 
    210                 215                 220                 


Asp Lys Glu Thr Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys Gly Ile 
225                 230                 235                 240 


Gln Lys Arg Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn 
                245                 250                 255     


Lys Phe Ala Val Glu Thr Leu Ile Cys Ser 
            260                 265     


<210>  2
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Lys Tyr Ile Lys Asp Asp Val Ile Leu Asn Glu Pro Ser Ala 
1               5                   10                  15      


Asp Ala Pro Ala Ala Leu Tyr Gln Thr Ile Glu Glu Asn Ile Lys Ile 
            20                  25                  30          


Phe Glu Glu Glu Glu Val Glu Phe Ile Ser Val Pro Val Pro Glu Phe 
        35                  40                  45              


Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys Leu 
    50                  55                  60                  


Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro Leu 
65                  70                  75                  80  


Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu Ile 
                85                  90                  95      


Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His Glu 
            100                 105                 110         


His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly Phe 
        115                 120                 125             


Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu Gln Arg 
    130                 135                 140                 


Arg Glu Thr 
145         


<210>  3
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys 
1               5                   10                  15      


Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp 
            20                  25                  30          


Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly 
        35                  40                  45              


Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met 
    50                  55                  60                  


Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala 
65                  70                  75                  80  


Leu Gln Pro Asp Asp Val Tyr Tyr Cys 
                85                  


<210>  4
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala 
1               5                   10                  15      


Val Glu Thr Leu Ile Cys Ser 
            20              


<210>  5
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly 
65                  70                  75                  80  


Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  6
<211>  95
<212>  PRT
<213>  Pan troglodytes

<400>  6

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly 
65                  70                  75                  80  


Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  7
<211>  95
<212>  PRT
<213>  Bos taurus

<400>  7

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Lys Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly 
65                  70                  75                  80  


Phe Tyr Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  8
<211>  95
<212>  PRT
<213>  Sus scrofa

<400>  8

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly 
65                  70                  75                  80  


Phe Tyr Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  9
<211>  95
<212>  PRT
<213>  Mus musculus

<400>  9

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Lys Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Val Asp Asn Leu Gly 
65                  70                  75                  80  


Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  10
<211>  95
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys 
1               5                   10                  15      


Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro 
            20                  25                  30          


Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu 
        35                  40                  45              


Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His 
    50                  55                  60                  


Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Val Asp His Leu Gly 
65                  70                  75                  80  


Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu 
                85                  90                  95  


<210>  11
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  12
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  13
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  13
ggtgccatgg gaata                                                        15


<210>  14
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  14
ctctagagga tccct                                                        15


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  15

Lys Phe Phe Glu Tyr Asn Gly Lys Lys Phe Phe Glu 
1               5                   10          


