                               SEQUENCE LISTING	

<110> MEDIMMUNE, LLC
 
<120> PROTEASE VARIANTS

<130> MED0538.PCT

<140> PCT/US2010/039392
<141> 2010-06-21

<150> 61/244,515
<151> 2009-09-22

<150> 61/218,733
<151> 2009-06-19

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 749
<212> PRT
<213> Homo sapiens

<400> 1
Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys 
1               5                   10                  15      


Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val 
            20                  25                  30          


Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr 
        35                  40                  45              


Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser 
    50                  55                  60                  


Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr 
65                  70                  75                  80  


Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile 
                85                  90                  95      


Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu 
            100                 105                 110         


Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp 
        115                 120                 125             


Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn 
    130                 135                 140                 


Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu 
145                 150                 155                 160 


Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys 
                165                 170                 175     


Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser 
            180                 185                 190         


Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp 
        195                 200                 205             


Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly 
    210                 215                 220                 


Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala 
225                 230                 235                 240 


Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg 
                245                 250                 255     


Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met 
            260                 265                 270         


Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys 
        275                 280                 285             


Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu 
    290                 295                 300                 


Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe 
305                 310                 315                 320 


Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser 
                325                 330                 335     


Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr 
            340                 345                 350         


Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn 
        355                 360                 365             


Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg 
    370                 375                 380                 


Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr 
385                 390                 395                 400 


Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly 
                405                 410                 415     


Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala 
            420                 425                 430         


Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu 
        435                 440                 445             


Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr 
    450                 455                 460                 


Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly 
465                 470                 475                 480 


Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr 
                485                 490                 495     


Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln 
            500                 505                 510         


Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys 
        515                 520                 525             


Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe 
    530                 535                 540                 


Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln 
545                 550                 555                 560 


Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly 
                565                 570                 575     


Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn 
            580                 585                 590         


Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln 
        595                 600                 605             


Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln 
    610                 615                 620                 


Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly 
625                 630                 635                 640 


Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln 
                645                 650                 655     


Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys 
            660                 665                 670         


Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn 
        675                 680                 685             


Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn 
    690                 695                 700                 


Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly 
705                 710                 715                 720 


Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys 
                725                 730                 735     


Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 


<210> 2
<211> 699
<212> PRT
<213> Homo sapiens

<400> 2
Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala 
1               5                   10                  15      


Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe 
            20                  25                  30          


Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu 
        35                  40                  45              


Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu 
    50                  55                  60                  


Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val 
65                  70                  75                  80  


Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser 
                85                  90                  95      


Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp 
            100                 105                 110         


Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly 
        115                 120                 125             


Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr 
    130                 135                 140                 


Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn 
145                 150                 155                 160 


Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro 
                165                 170                 175     


Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr 
            180                 185                 190         


Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu 
        195                 200                 205             


Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys 
    210                 215                 220                 


Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu 
225                 230                 235                 240 


Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln 
                245                 250                 255     


Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp 
            260                 265                 270         


Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr 
        275                 280                 285             


Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu 
    290                 295                 300                 


Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met 
305                 310                 315                 320 


Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr 
                325                 330                 335     


Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser 
            340                 345                 350         


Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met 
        355                 360                 365             


Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu 
    370                 375                 380                 


Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe 
385                 390                 395                 400 


Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys 
                405                 410                 415     


Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro 
            420                 425                 430         


Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu 
        435                 440                 445             


Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu 
    450                 455                 460                 


Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp 
465                 470                 475                 480 


Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser 
                485                 490                 495     


Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro 
            500                 505                 510         


Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly 
        515                 520                 525             


Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg 
    530                 535                 540                 


Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser 
545                 550                 555                 560 


Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly 
                565                 570                 575     


Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn 
            580                 585                 590         


Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr 
        595                 600                 605             


Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu 
    610                 615                 620                 


Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala 
625                 630                 635                 640 


Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile 
                645                 650                 655     


Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu 
            660                 665                 670         


Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser 
        675                 680                 685             


Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
    690                 695                 


<210> 3
<211> 728
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val Pro Asp 
1               5                   10                  15      


Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ser Tyr Asp Asp 
            20                  25                  30          


Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu Ile 
        35                  40                  45              


Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys Tyr 
    50                  55                  60                  


Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser Ser 
65                  70                  75                  80  


Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val Leu 
                85                  90                  95      


Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val Gln 
            100                 105                 110         


Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile Asp 
        115                 120                 125             


Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr Gly 
    130                 135                 140                 


Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser Trp 
145                 150                 155                 160 


Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys Lys 
                165                 170                 175     


Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val Asn 
            180                 185                 190         


His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg Asp 
        195                 200                 205             


Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr Val 
    210                 215                 220                 


Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg Leu 
225                 230                 235                 240 


Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met Glu 
                245                 250                 255     


Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg Asn 
            260                 265                 270         


Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln Asn 
        275                 280                 285             


Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn Phe 
    290                 295                 300                 


Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu Glu 
305                 310                 315                 320 


Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro Ile 
                325                 330                 335     


Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp Arg 
            340                 345                 350         


Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu Ser 
        355                 360                 365             


Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr Thr Ser Glu Thr Ala 
    370                 375                 380                 


Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Glu Asn Ala 
385                 390                 395                 400 


Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys His 
                405                 410                 415     


Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln Thr 
            420                 425                 430         


Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys Arg Ala Glu 
        435                 440                 445             


Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro Asp Asp Ile 
    450                 455                 460                 


Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu Leu Asn Tyr 
465                 470                 475                 480 


Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu Lys Phe Ser 
                485                 490                 495     


Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp Lys Asp Glu 
            500                 505                 510         


Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser Ser Gly Arg 
        515                 520                 525             


Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro Phe Phe Ser 
    530                 535                 540                 


Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly Met Val Ile 
545                 550                 555                 560 


Gly His Glu Ile Thr His Gly Phe Asp Asp Asn Gly Arg Asn Phe Asn 
                565                 570                 575     


Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln Gln Ser Ala Ser Asn 
            580                 585                 590         


Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly Asn Phe Ser 
        595                 600                 605             


Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn Thr Leu Gly 
    610                 615                 620                 


Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr Arg Ala Tyr 
625                 630                 635                 640 


Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu Pro Gly Leu 
                645                 650                 655     


Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala Gln Val Trp 
            660                 665                 670         


Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile Lys Thr Asp 
        675                 680                 685             


Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly Thr Leu Gln Asn Ser 
    690                 695                 700                 


Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser Tyr Met Asn 
705                 710                 715                 720 


Pro Glu Lys Lys Cys Arg Val Trp 
                725             


<210> 4
<211> 2100
<212> DNA
<213> Homo sapiens

<400> 4
tacgatgatg gtatttgcaa gtcatcagac tgcataaaat cagctgctcg actgatccaa       60

aacatggatg ccaccactga gccttgtaca gactttttca aatatgcttg cggaggctgg      120

ttgaaacgta atgtcattcc cgagaccagc tcccgttacg gcaactttga cattttaaga      180

gatgaactag aagtcgtttt gaaagatgtc cttcaagaac ccaaaactga agatatagta      240

gcagtgcaga aagcaaaagc attgtacagg tcttgtataa atgaatctgc tattgatagc      300

agaggtggag aacctctact caaactgtta ccagacatat atgggtggcc agtagcaaca      360

gaaaactggg agcaaaaata tggtgcttct tggacagctg aaaaagctat tgcacaactg      420

aattctaaat atgggaaaaa agtccttatt aatttgtttg ttggcactga tgataagaat      480

tctgtgaatc atgtaattca tattgaccaa cctcgacttg gcctcccttc tagagattac      540

tatgaatgca ctggaatcta taaagaggct tgtacagcat atgtggattt tatgatttct      600

gtggccagat tgattcgtca ggaagaaaga ttgcccatcg atgaaaacca gcttgctttg      660

gaaatgaata aagttatgga attggaaaaa gaaattgcca atgctacggc taaacctgaa      720

gatcgaaatg atccaatgct tctgtataac aagatgacat tggcccagat ccaaaataac      780

ttttcactag agatcaatgg gaagccattc agctggttga atttcacaaa tgaaatcatg      840

tcaactgtga atattagtat tacaaatgag gaagatgtgg ttgtttatgc tccagaatat      900

ttaaccaaac ttaagcccat tcttaccaaa tattctgcca gagatcttca aaatttaatg      960

tcctggagat tcataatgga tcttgtaagc agcctcagcc gaacctacaa ggagtccaga     1020

aatgctttcc gcaaggccct ttatggtaca acctcagaaa cagcaacttg gagacgttgt     1080

gcaaactatg tcaatgggaa tatggaaaat gctgtgggga ggctttatgt ggaagcagca     1140

tttgctggag agagtaaaca tgtggtcgag gatttgattg cacagatccg agaagttttt     1200

attcagactt tagatgacct cacttggatg gatgccgaga caaaaaagag agctgaagaa     1260

aaggccttag caattaaaga aaggatcggc tatcctgatg acattgtttc aaatgataac     1320

aaactgaata atgagtactt ggagttgaac tacaaagaag atgaatactt cgagaacata     1380

attcaaaatt tgaaattcag ccaaagtaaa caactgaaga agctccgaga aaaggtggac     1440

aaagatgagt ggataagtgg agcagctgta gtcaatgcat tttactcttc aggaagaaat     1500

cagatagtct tcccagccgg cattctgcag ccccccttct ttagtgccca gcagtccaac     1560

tcattgaact atgggggcat cggcatggtc ataggacacg aaatcaccca tggcttcgat     1620

gacaatggca gaaactttaa caaagatgga gacctcgttg actggtggac tcaacagtct     1680

gcaagtaact ttaaggagca atcccagtgc atggtgtatc agtatggaaa cttttcctgg     1740

gacctggcag gtggacagca ccttaatgga attaatacac tgggagaaaa cattgctgat     1800

aatggaggtc ttggtcaagc atacagagcc tatcagaatt atattaaaaa gaatggcgaa     1860

gaaaaattac ttcctggact tgacctaaat cacaaacaac tatttttctt gaactttgca     1920

caggtgtggt gtggaaccta taggccagag tatgcggtta actccattaa aacagatgtg     1980

cacagtccag gcaatttcag gattattggg actttgcaga actctgcaga gttttcagaa     2040

gcctttcact gccgcaagaa ttcatacatg aatccagaaa agaagtgccg ggtttggtga     2100


<210> 5
<211> 2187
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 5
tatccatatg acgtcccaga ctatgcttat ccatatgacg tcccagacta tgcttaccct       60

tacgatgtac ctgattacgc aggatcctac gatgatggta tttgcaagtc atcagactgc      120

ataaaatcag ctgctcgact gatccaaaac atggatgcca ccactgagcc ttgtacagac      180

tttttcaaat atgcttgcgg aggctggttg aaacgtaatg tcattcccga gaccagctcc      240

cgttacggca actttgacat tttaagagat gaactagaag tcgttttgaa agatgtcctt      300

caagaaccca aaactgaaga tatagtagca gtgcagaaag caaaagcatt gtacaggtct      360

tgtataaatg aatctgctat tgatagcaga ggtggagaac ctctactcaa actgttacca      420

gacatatatg ggtggccagt agcaacagaa aactgggagc aaaaatatgg tgcttcttgg      480

acagctgaaa aagctattgc acaactgaat tctaaatatg ggaaaaaagt ccttattaat      540

ttgtttgttg gcactgatga taagaattct gtgaatcatg taattcatat tgaccaacct      600

cgacttggcc tcccttctag agattactat gaatgcactg gaatctataa agaggcttgt      660

acagcatatg tggattttat gatttctgtg gccagattga ttcgtcagga agaaagattg      720

cccatcgatg aaaaccagct tgctttggaa atgaataaag ttatggaatt ggaaaaagaa      780

attgccaatg ctacggctaa acctgaagat cgaaatgatc caatgcttct gtataacaag      840

atgacattgg cccagatcca aaataacttt tcactagaga tcaatgggaa gccattcagc      900

tggttgaatt tcacaaatga aatcatgtca actgtgaata ttagtattac aaatgaggaa      960

gatgtggttg tttatgctcc agaatattta accaaactta agcccattct taccaaatat     1020

tctgccagag atcttcaaaa tttaatgtcc tggagattca taatggatct tgtaagcagc     1080

ctcagccgaa cctacaagga gtccagaaat gctttccgca aggcccttta tggtacaacc     1140

tcagaaacag caacttggag acgttgtgca aactatgtca atgggaatat ggaaaatgct     1200

gtggggaggc tttatgtgga agcagcattt gctggagaga gtaaacatgt ggtcgaggat     1260

ttgattgcac agatccgaga agtttttatt cagactttag atgacctcac ttggatggat     1320

gccgagacaa aaaagagagc tgaagaaaag gccttagcaa ttaaagaaag gatcggctat     1380

cctgatgaca ttgtttcaaa tgataacaaa ctgaataatg agtacttgga gttgaactac     1440

aaagaagatg aatacttcga gaacataatt caaaatttga aattcagcca aagtaaacaa     1500

ctgaagaagc tccgagaaaa ggtggacaaa gatgagtgga taagtggagc agctgtagtc     1560

aatgcatttt actcttcagg aagaaatcag atagtcttcc cagccggcat tctgcagccc     1620

cccttcttta gtgcccagca gtccaactca ttgaactatg ggggcatcgg catggtcata     1680

ggacacgaaa tcacccatgg cttcgatgac aatggcagaa actttaacaa agatggagac     1740

ctcgttgact ggtggactca acagtctgca agtaacttta aggagcaatc ccagtgcatg     1800

gtgtatcagt atggaaactt ttcctgggac ctggcaggtg gacagcacct taatggaatt     1860

aatacactgg gagaaaacat tgctgataat ggaggtcttg gtcaagcata cagagcctat     1920

cagaattata ttaaaaagaa tggcgaagaa aaattacttc ctggacttga cctaaatcac     1980

aaacaactat ttttcttgaa ctttgcacag gtgtggtgtg gaacctatag gccagagtat     2040

gcggttaact ccattaaaac agatgtgcac agtccaggca atttcaggat tattgggact     2100

ttgcagaact ctgcagagtt ttcagaagcc tttcactgcc gcaagaattc atacatgaat     2160

ccagaaaaga agtgccgggt ttggtga                                         2187


<210> 6
<211> 2250
<212> DNA
<213> Homo sapiens

<400> 6
ggcaagtcag aaagtcagat ggatataact gatatcaaca ctccaaagcc aaagaagaaa       60

cagcgatgga ctccactgga gatcagcctc tcggtccttg tcctgctcct caccatcata      120

gctgtgacaa tgatcgcact ctatgcaacc tacgatgatg gtatttgcaa gtcatcagac      180

tgcataaaat cagctgctcg actgatccaa aacatggatg ccaccactga gccttgtaca      240

gactttttca aatatgcttg cggaggctgg ttgaaacgta atgtcattcc cgagaccagc      300

tcccgttacg gcaactttga cattttaaga gatgaactag aagtcgtttt gaaagatgtc      360

cttcaagaac ccaaaactga agatatagta gcagtgcaga aagcaaaagc attgtacagg      420

tcttgtataa atgaatctgc tattgatagc agaggtggag aacctctact caaactgtta      480

ccagacatat atgggtggcc agtagcaaca gaaaactggg agcaaaaata tggtgcttct      540

tggacagctg aaaaagctat tgcacaactg aattctaaat atgggaaaaa agtccttatt      600

aatttgtttg ttggcactga tgataagaat tctgtgaatc atgtaattca tattgaccaa      660

cctcgacttg gcctcccttc tagagattac tatgaatgca ctggaatcta taaagaggct      720

tgtacagcat atgtggattt tatgatttct gtggccagat tgattcgtca ggaagaaaga      780

ttgcccatcg atgaaaacca gcttgctttg gaaatgaata aagttatgga attggaaaaa      840

gaaattgcca atgctacggc taaacctgaa gatcgaaatg atccaatgct tctgtataac      900

aagatgacat tggcccagat ccaaaataac ttttcactag agatcaatgg gaagccattc      960

agctggttga atttcacaaa tgaaatcatg tcaactgtga atattagtat tacaaatgag     1020

gaagatgtgg ttgtttatgc tccagaatat ttaaccaaac ttaagcccat tcttaccaaa     1080

tattctgcca gagatcttca aaatttaatg tcctggagat tcataatgga tcttgtaagc     1140

agcctcagcc gaacctacaa ggagtccaga aatgctttcc gcaaggccct ttatggtaca     1200

acctcagaaa cagcaacttg gagacgttgt gcaaactatg tcaatgggaa tatggaaaat     1260

gctgtgggga ggctttatgt ggaagcagca tttgctggag agagtaaaca tgtggtcgag     1320

gatttgattg cacagatccg agaagttttt attcagactt tagatgacct cacttggatg     1380

gatgccgaga caaaaaagag agctgaagaa aaggccttag caattaaaga aaggatcggc     1440

tatcctgatg acattgtttc aaatgataac aaactgaata atgagtacct cgagttgaac     1500

tacaaagaag atgaatactt cgagaacata attcaaaatt tgaaattcag ccaaagtaaa     1560

caactgaaga agctccgaga aaaggtggac aaagatgagt ggataagtgg agcagctgta     1620

gtcaatgcat tttactcttc aggaagaaat cagatagtct tcccagccgg cattctgcag     1680

ccccccttct ttagtgccca gcagtccaac tcattgaact atgggggcat cggcatggtc     1740

ataggacacg aaatcaccca tggcttcgat gacaatggca gaaactttaa caaagatgga     1800

gacctcgttg actggtggac tcaacagtct gcaagtaact ttaaggagca atcccagtgc     1860

atggtgtatc agtatggaaa cttttcctgg gacctggcag gtggacagca ccttaatgga     1920

attaatacac tgggagaaaa cattgctgat aatggaggtc ttggtcaagc atacagagcc     1980

tatcagaatt atattaaaaa gaatggcgaa gaaaaattac ttcctggact tgacctaaat     2040

cacaaacaac tatttttctt gaactttgca caggtgtggt gtggaaccta taggccagag     2100

tatgcggtta actccattaa aacagatgtg cacagtccag gcaatttcag gattattggg     2160

actttgcaga actctgcaga gttttcagaa gcctttcact gccgcaagaa ttcatacatg     2220

aatccagaaa agaagtgccg ggtttggtga                                      2250


<210> 7
<211> 8339
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      expression vector"

<400> 7
acggattaga agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt       60

cctcgtcctc accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga      120

acaataaaga ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac      180

ctggccccac aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga      240

ttagtttttt agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat      300

taacagatat ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc      360

ggtttgtatt acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac      420

ctctatactt taacgtcaag gagaaaaaac cccggatcgg actactagca gctgtaatac      480

gactcactat agggaatatt aagcttatga gatttccttc aatttttact gctgttttat      540

tcgcagcatc ctctgcatta gctgctccag tcaacactat aacagaagat gaaacggcac      600

aaattcctgc tgaagctgtc atcggttact cagatttaga aggggatttc gatgttgctg      660

ttttgccatt ttccaacagc acaaataacg ggttattgtt tatgaatact actactgcca      720

gcattgctgc taaagaagaa gtggtatctc tcgagaaaag agaggctgaa gcttatccat      780

atgacgtccc agactatgct tatccatatg acgtcccaga ctatgcttac ccttacgatg      840

tacctgatta cgcaggatcc tacgatgatg gtatttgcaa gtcatcagac tgcataaaat      900

cagctgctcg actgatccaa aacatggatg ccaccactga gccttgtaca gactttttca      960

aatatgcttg cggaggctgg ttgaaacgta atgtcattcc cgagaccagc tcccgttacg     1020

gcaactttga cattttaaga gatgaactag aagtcgtttt gaaagatgtc cttcaagaac     1080

ccaaaactga agatatagta gcagtgcaga aagcaaaagc attgtacagg tcttgtataa     1140

atgaatctgc tattgatagc agaggtggag aacctctact caaactgtta ccagacatat     1200

atgggtggcc agtagcaaca gaaaactggg agcaaaaata tggtgcttct tggacagctg     1260

aaaaagctat tgcacaactg aattctaaat atgggaaaaa agtccttatt aatttgtttg     1320

ttggcactga tgataagaat tctgtgaatc atgtaattca tattgaccaa cctcgacttg     1380

gcctcccttc tagagattac tatgaatgca ctggaatcta taaagaggct tgtacagcat     1440

atgtggattt tatgatttct gtggccagat tgattcgtca ggaagaaaga ttgcccatcg     1500

atgaaaacca gcttgctttg gaaatgaata aagttatgga attggaaaaa gaaattgcca     1560

atgctacggc taaacctgaa gatcgaaatg atccaatgct tctgtataac aagatgacat     1620

tggcccagat ccaaaataac ttttcactag agatcaatgg gaagccattc agctggttga     1680

atttcacaaa tgaaatcatg tcaactgtga atattagtat tacaaatgag gaagatgtgg     1740

ttgtttatgc tccagaatat ttaaccaaac ttaagcccat tcttaccaaa tattctgcca     1800

gagatcttca aaatttaatg tcctggagat tcataatgga tcttgtaagc agcctcagcc     1860

gaacctacaa ggagtccaga aatgctttcc gcaaggccct ttatggtaca acctcagaaa     1920

cagcaacttg gagacgttgt gcaaactatg tcaatgggaa tatggaaaat gctgtgggga     1980

ggctttatgt ggaagcagca tttgctggag agagtaaaca tgtggtcgag gatttgattg     2040

cacagatccg agaagttttt attcagactt tagatgacct cacttggatg gatgccgaga     2100

caaaaaagag agctgaagaa aaggccttag caattaaaga aaggatcggc tatcctgatg     2160

acattgtttc aaatgataac aaactgaata atgagtactt ggagttgaac tacaaagaag     2220

atgaatactt cgagaacata attcaaaatt tgaaattcag ccaaagtaaa caactgaaga     2280

agctccgaga aaaggtggac aaagatgagt ggataagtgg agcagctgta gtcaatgcat     2340

tttactcttc aggaagaaat cagatagtct tcccagccgg cattctgcag ccccccttct     2400

ttagtgccca gcagtccaac tcattgaact atgggggcat cggcatggtc ataggacacg     2460

aaatcaccca tggcttcgat gacaatggca gaaactttaa caaagatgga gacctcgttg     2520

actggtggac tcaacagtct gcaagtaact ttaaggagca atcccagtgc atggtgtatc     2580

agtatggaaa cttttcctgg gacctggcag gtggacagca ccttaatgga attaatacac     2640

tgggagaaaa cattgctgat aatggaggtc ttggtcaagc atacagagcc tatcagaatt     2700

atattaaaaa gaatggcgaa gaaaaattac ttcctggact tgacctaaat cacaaacaac     2760

tatttttctt gaactttgca caggtgtggt gtggaaccta taggccagag tatgcggtta     2820

actccattaa aacagatgtg cacagtccag gcaatttcag gattattggg actttgcaga     2880

actctgcaga gttttcagaa gcctttcact gccgcaagaa ttcatacatg aatccagaaa     2940

agaagtgccg ggtttggtga gcggccgcca ccgcggtgga gctccagctt ttgttccctt     3000

tagtgagggt taattgcgcg cttggcgtaa tcatggtcat agctgtttcc tgtgagatct     3060

cctaccgcat gcatctagct agagggccgc atcatgtaat tagttatgtc acgcttacat     3120

tcacgccctc cccccacatc cgctctaacc gaaaaggaag gagttagaca acctgaagtc     3180

taggtcccta tttatttttt tatagttatg ttagtattaa gaacgttatt tatatttcaa     3240

atttttcttt tttttctgta cagacgcgtg tacgcatgta acattatact gaaaaccttg     3300

cttgagaagg ttttgggacg ctcgaaggct ttaatttgcg gccctgcatt aatgaatcgg     3360

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga     3420

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat     3480

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca     3540

aaagcccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc     3600

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata     3660

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc     3720

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc     3780

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga     3840

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc     3900

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag     3960

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag     4020

gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag     4080

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca     4140

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga     4200

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat     4260

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga     4320

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg     4380

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga     4440

gcgcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc     4500

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac     4560

tttatccgcc tccattcagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc     4620

agttaatagt ttgcgcaacg ttgttggcat tgctacaggc atcgtggtgt cactctcgtc     4680

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc     4740

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt     4800

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc     4860

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg     4920

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataatagtg tatcacatag     4980

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat     5040

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc     5100

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa     5160

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatgggt     5220

aataactgat ataattaaat tgaagctcta atttgtgagt ttagtataca tgcatttact     5280

tataatacag ttttttagtt ttgctggccg catcttctca aatatgcttc ccagcctgct     5340

tttctgtaac gttcaccctc taccttagca tcccttccct ttgcaaatag tcctcttcca     5400

acaataataa tgtcagatcc tgtagagacc acatcatcca cggttctata ctgttgaccc     5460

aatgcgtctc ccttgtcatc taaacccaca ccgggtgtca taatcaacca atcgtaacct     5520

tcatctcttc cacccatgtc tctttgagca ataaagccga taacaaaatc tttgtcgctc     5580

ttcgcaatgt caacagtacc cttagtatat tctccagtag atagggagcc cttgcatgac     5640

aattctgcta acatcaaaag gcctctaggt tcctttgtta cttcttctgc cgcctgcttc     5700

aaaccgctaa caatacctgg gcccaccaca ccgtgtgcat tcgtaatgtc tgcccattct     5760

gctattctgt atacacccgc agagtactgc aatttgactg tattaccaat gtcagcaaat     5820

tttctgtctt cgaagagtaa aaaattgtac ttggcggata atgcctttag cggcttaact     5880

gtgccctcca tggaaaaatc agtcaagata tccacatgtg tttttagtaa acaaattttg     5940

ggacctaatg cttcaactaa ctccagtaat tccttggtgg tacgaacatc caatgaagca     6000

cacaagtttg tttgcttttc gtgcatgata ttaaatagct tggcagcaac aggactagga     6060

tgagtagcag cacgttcctt atatgtagct ttcgacatga tttatcttcg tttcctgcag     6120

gtttttgttc tgtgcagttg ggttaagaat actgggcaat ttcatgtttc ttcaacacta     6180

catatgcgta tatataccaa tctaagtctg tgctccttcc ttcgttcttc cttctgttcg     6240

gagattaccg aatcaaaaaa atttcaaaga aaccgaaatc aaaaaaaaga ataaaaaaaa     6300

aatgatgaat tgaattgaaa agctagctta tcgatgataa gctgtcaaag atgagaatta     6360

attccacgga ctatagacta tactagatac tccgtctact gtacgataca cttccgctca     6420

ggtccttgtc ctttaacgag gccttaccac tcttttgtta ctctattgat ccagctcagc     6480

aaaggcagtg tgatctaaga ttctatcttc gcgatgtagt aaaactagct agaccgagaa     6540

agagactaga aatgcaaaag gcacttctac aatggctgcc atcattatta tccgatgtga     6600

cgctgcagct tctcaatgat attcgaatac gctttgagga gatacagcct aatatccgac     6660

aaactgtttt acagatttac gatcgtactt gttacccatc attgaatttt gaacatccga     6720

acctgggagt tttccctgaa acagatagta tatttgaacc tgtataataa tatatagtct     6780

agcgctttac ggaagacaat gtatgtattt cggttcctgg agaaactatt gcatctattg     6840

cataggtaat cttgcacgtc gcatccccgg ttcattttct gcgtttccat cttgcacttc     6900

aatagcatat ctttgttaac gaagcatctg tgcttcattt tgtagaacaa aaatgcaacg     6960

cgagagcgct aatttttcaa acaaagaatc tgagctgcat ttttacagaa cagaaatgca     7020

acgcgaaagc gctattttac caacgaagaa tctgtgcttc atttttgtaa aacaaaaatg     7080

caacgcgacg agagcgctaa tttttcaaac aaagaatctg agctgcattt ttacagaaca     7140

gaaatgcaac gcgagagcgc tattttacca acaaagaatc tatacttctt ttttgttcta     7200

caaaaatgca tcccgagagc gctatttttc taacaaagca tcttagatta ctttttttct     7260

cctttgtgcg ctctataatg cagtctcttg ataacttttt gcactgtagg tccgttaagg     7320

ttagaagaag gctactttgg tgtctatttt ctcttccata aaaaaagcct gactccactt     7380

cccgcgttta ctgattacta gcgaagctgc gggtgcattt tttcaagata aaggcatccc     7440

cgattatatt ctataccgat gtggattgcg catactttgt gaacagaaag tgatagcgtt     7500

gatgattctt cattggtcag aaaattatga acggtttctt ctattttgtc tctatatact     7560

acgtatagga aatgtttaca ttttcgtatt gttttcgatt cactctatga atagttctta     7620

ctacaatttt tttgtctaaa gagtaatact agagataaac ataaaaaatg tagaggtcga     7680

gtttagatgc aagttcaagg agcgaaaggt ggatgggtag gttatatagg gatatagcac     7740

agagatatat agcaaagaga tacttttgag caatgtttgt ggaagcggta ttcgcaatgg     7800

gaagctccac cccggttgat aatcagaaaa gccccaaaaa caggaagatt gtataagcaa     7860

atatttaaat tgtaaacgtt aatattttgt taaaattcgc gttaaatttt tgttaaatca     7920

gctcattttt taacgaatag cccgaaatcg gcaaaatccc ttataaatca aaagaataga     7980

ccgagatagg gttgagtgtt gttccagttt ccaacaagag tccactatta aagaacgtgg     8040

actccaacgt caaagggcga aaaagggtct atcagggcga tggcccacta cgtgaaccat     8100

caccctaatc aagttttttg gggtcgaggt gccgtaaagc agtaaatcgg aagggtaaac     8160

ggatgccccc atttagagct tgacggggaa agccggcgaa cgtggcgaga aaggaaggga     8220

agaaagcgaa aggagcgggg gctagggcgg tgggaagtgt aggggtcacg ctgggcgtaa     8280

ccaccacacc cgccgcgctt aatggggcgc tacagggcgc gtggggatga tccactagt      8339


<210> 8
<211> 41
<212> PRT
<213> Homo sapiens

<400> 8
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Lys 
        35                  40      


<210> 9
<211> 43
<212> PRT
<213> Homo sapiens

<400> 9
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Lys 
        35                  40              


<210> 10
<211> 29
<212> PRT
<213> Homo sapiens

<400> 10
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr Lys 
            20                  25                  


<210> 11
<211> 33
<212> PRT
<213> Homo sapiens

<400> 11
Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      


Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


Lys 
    


<210> 12
<211> 12
<212> PRT
<213> Homo sapiens

<400> 12
Cys Asp Arg Val Tyr Ile His Pro Phe His Leu Lys 
1               5                   10          


<210> 13
<211> 23
<212> PRT
<213> Homo sapiens

<400> 13
Gly Cys Ser Ser Ser Ser Leu Met Asp Lys Glu Ser Val Tyr Phe Cys 
1               5                   10                  15      


His Leu Asp Ile Ile Trp Lys 
            20              


<210> 14
<211> 23
<212> PRT
<213> Homo sapiens

<400> 14
Gly Ser Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr Phe Ser 
1               5                   10                  15      


His Leu Asp Ile Ile Trp Lys 
            20              


<210> 15
<211> 38
<212> PRT
<213> Homo sapiens

<400> 15
Cys Tyr Pro Ser Lys Pro Asp Asn Pro Gly Glu Asp Ala Pro Ala Glu 
1               5                   10                  15      


Asp Met Ala Arg Tyr Tyr Ser Ala Leu Arg His Tyr Ile Asn Leu Ile 
            20                  25                  30          


Thr Arg Gln Arg Tyr Lys 
        35              


<210> 16
<211> 15
<212> PRT
<213> Homo sapiens

<400> 16
Cys Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu Lys 
1               5                   10                  15  


<210> 17
<211> 31
<212> PRT
<213> Homo sapiens

<400> 17
Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Lys 
            20                  25                  30      


<210> 18
<211> 11
<212> PRT
<213> Homo sapiens

<400> 18
Cys Arg Pro Pro Gly Phe Ser Pro Phe Arg Lys 
1               5                   10      


<210> 19
<211> 72
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      PCR primer NEP-85A"

<400> 19
gacgtcccag actatgctta cccttacgat gtacctgatt acgcaggatc ctacgatgat       60

ggtatttgca ag                                                           72


<210> 20
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      PCR primer NEP-24"

<400> 20
atagtttagc ggccgctcac caaacccggc actt                                   34


<210> 21
<211> 87
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      PCR primer NEP-85B"

<400> 21
gtatctctcg agaaaagaga ggctgaagct tatccatatg acgtcccaga ctatgcttat       60

ccatatgacg tcccagacta tgcttac                                           87


<210> 22
<211> 5856
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      expression vector pYES2"

<400> 22
acggattaga agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt       60

cctcgtcttc accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga      120

acaataaaga ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac      180

ctggccccac aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga      240

ttagtttttt agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat      300

taacagatat ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc      360

ggtttgtatt acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac      420

ctctatactt taacgtcaag gagaaaaaac cccggatcgg actactagca gctgtaatac      480

gactcactat agggaatatt aagcttggta ccgagctcgg atccactagt aacggccgcc      540

agtgtgctgg aattctgcag atatccatca cactggcggc cgctcgagca tgcatctaga      600

gggccgcatc atgtaattag ttatgtcacg cttacattca cgccctcccc ccacatccgc      660

tctaaccgaa aaggaaggag ttagacaacc tgaagtctag gtccctattt atttttttat      720

agttatgtta gtattaagaa cgttatttat atttcaaatt tttctttttt ttctgtacag      780

acgcgtgtac gcatgtaaca ttatactgaa aaccttgctt gagaaggttt tgggacgctc      840

gaaggcttta atttgcggcc ctgcattaat gaatcggcca acgcgcgggg agaggcggtt      900

tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc      960

tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg     1020

ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa gcccaggaac cgtaaaaagg     1080

ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac     1140

gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg     1200

gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct     1260

ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg     1320

tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct     1380

gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac     1440

tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt     1500

tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt atctgcgctc     1560

tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca     1620

ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat     1680

ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac     1740

gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt     1800

aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc     1860

aatgcttaat cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg     1920

cctgactccc cgtcgtgtag ataactacga tacgggagcg cttaccatct ggccccagtg     1980

ctgcaatgat accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc     2040

cagccggaag ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc attcagtcta     2100

ttaattgttg ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg     2160

ttggcattgc tacaggcatc gtggtgtcac tctcgtcgtt tggtatggct tcattcagct     2220

ccggttccca acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta     2280

gctccttcgg tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg     2340

ttatggcagc actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga     2400

ctggtgagta ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt     2460

gcccggcgtc aatacgggat aatagtgtat cacatagcag aactttaaaa gtgctcatca     2520

ttggaaaacg ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt     2580

cgatgtaacc cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt     2640

ctgggtgagc aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga     2700

aatgttgaat actcatactc ttcctttttc aatgggtaat aactgatata attaaattga     2760

agctctaatt tgtgagttta gtatacatgc atttacttat aatacagttt tttagttttg     2820

ctggccgcat cttctcaaat atgcttccca gcctgctttt ctgtaacgtt caccctctac     2880

cttagcatcc cttccctttg caaatagtcc tcttccaaca ataataatgt cagatcctgt     2940

agagaccaca tcatccacgg ttctatactg ttgacccaat gcgtctccct tgtcatctaa     3000

acccacaccg ggtgtcataa tcaaccaatc gtaaccttca tctcttccac ccatgtctct     3060

ttgagcaata aagccgataa caaaatcttt gtcgctcttc gcaatgtcaa cagtaccctt     3120

agtatattct ccagtagata gggagccctt gcatgacaat tctgctaaca tcaaaaggcc     3180

tctaggttcc tttgttactt cttctgccgc ctgcttcaaa ccgctaacaa tacctgggcc     3240

caccacaccg tgtgcattcg taatgtctgc ccattctgct attctgtata cacccgcaga     3300

gtactgcaat ttgactgtat taccaatgtc agcaaatttt ctgtcttcga agagtaaaaa     3360

attgtacttg gcggataatg cctttagcgg cttaactgtg ccctccatgg aaaaatcagt     3420

caagatatcc acatgtgttt ttagtaaaca aattttggga cctaatgctt caactaactc     3480

cagtaattcc ttggtggtac gaacatccaa tgaagcacac aagtttgttt gcttttcgtg     3540

catgatatta aatagcttgg cagcaacagg actaggatga gtagcagcac gttccttata     3600

tgtagctttc gacatgattt atcttcgttt cctgcaggtt tttgttctgt gcagttgggt     3660

taagaatact gggcaatttc atgtttcttc aacactacat atgcgtatat ataccaatct     3720

aagtctgtgc tccttccttc gttcttcctt ctgttcggag attaccgaat caaaaaaatt     3780

tcaaagaaac cgaaatcaaa aaaaagaata aaaaaaaaat gatgaattga attgaaaagc     3840

tagcttatcg atgataagct gtcaaagatg agaattaatt ccacggacta tagactatac     3900

tagatactcc gtctactgta cgatacactt ccgctcaggt ccttgtcctt taacgaggcc     3960

ttaccactct tttgttactc tattgatcca gctcagcaaa ggcagtgtga tctaagattc     4020

tatcttcgcg atgtagtaaa actagctaga ccgagaaaga gactagaaat gcaaaaggca     4080

cttctacaat ggctgccatc attattatcc gatgtgacgc tgcagcttct caatgatatt     4140

cgaatacgct ttgaggagat acagcctaat atccgacaaa ctgttttaca gatttacgat     4200

cgtacttgtt acccatcatt gaattttgaa catccgaacc tgggagtttt ccctgaaaca     4260

gatagtatat ttgaacctgt ataataatat atagtctagc gctttacgga agacaatgta     4320

tgtatttcgg ttcctggaga aactattgca tctattgcat aggtaatctt gcacgtcgca     4380

tccccggttc attttctgcg tttccatctt gcacttcaat agcatatctt tgttaacgaa     4440

gcatctgtgc ttcattttgt agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca     4500

aagaatctga gctgcatttt tacagaacag aaatgcaacg cgaaagcgct attttaccaa     4560

cgaagaatct gtgcttcatt tttgtaaaac aaaaatgcaa cgcgacgaga gcgctaattt     4620

ttcaaacaaa gaatctgagc tgcattttta cagaacagaa atgcaacgcg agagcgctat     4680

tttaccaaca aagaatctat acttcttttt tgttctacaa aaatgcatcc cgagagcgct     4740

atttttctaa caaagcatct tagattactt tttttctcct ttgtgcgctc tataatgcag     4800

tctcttgata actttttgca ctgtaggtcc gttaaggtta gaagaaggct actttggtgt     4860

ctattttctc ttccataaaa aaagcctgac tccacttccc gcgtttactg attactagcg     4920

aagctgcggg tgcatttttt caagataaag gcatccccga ttatattcta taccgatgtg     4980

gattgcgcat actttgtgaa cagaaagtga tagcgttgat gattcttcat tggtcagaaa     5040

attatgaacg gtttcttcta ttttgtctct atatactacg tataggaaat gtttacattt     5100

tcgtattgtt ttcgattcac tctatgaata gttcttacta caattttttt gtctaaagag     5160

taatactaga gataaacata aaaaatgtag aggtcgagtt tagatgcaag ttcaaggagc     5220

gaaaggtgga tgggtaggtt atatagggat atagcacaga gatatatagc aaagagatac     5280

ttttgagcaa tgtttgtgga agcggtattc gcaatgggaa gctccacccc ggttgataat     5340

cagaaaagcc ccaaaaacag gaagattgta taagcaaata tttaaattgt aaacgttaat     5400

attttgttaa aattcgcgtt aaatttttgt taaatcagct cattttttaa cgaatagccc     5460

gaaatcggca aaatccctta taaatcaaaa gaatagaccg agatagggtt gagtgttgtt     5520

ccagtttcca acaagagtcc actattaaag aacgtggact ccaacgtcaa agggcgaaaa     5580

agggtctatc agggcgatgg cccactacgt gaaccatcac cctaatcaag ttttttgggg     5640

tcgaggtgcc gtaaagcagt aaatcggaag ggtaaacgga tgcccccatt tagagcttga     5700

cggggaaagc cggcgaacgt ggcgagaaag gaagggaaga aagcgaaagg agcgggggct     5760

agggcggtgg gaagtgtagg ggtcacgctg ggcgtaacca ccacacccgc cgcgcttaat     5820

ggggcgctac agggcgcgtg gggatgatcc actagt                               5856


<210> 23
<211> 6631
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      expression vector pESC-URA"

<400> 23
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accataccac agcttttcaa ttcaattcat catttttttt ttattctttt ttttgatttc      240

ggtttctttg aaattttttt gattcggtaa tctccgaaca gaaggaagaa cgaaggaagg      300

agcacagact tagattggta tatatacgca tatgtagtgt tgaagaaaca tgaaattgcc      360

cagtattctt aacccaactg cacagaacaa aaacctgcag gaaacgaaga taaatcatgt      420

cgaaagctac atataaggaa cgtgctgcta ctcatcctag tcctgttgct gccaagctat      480

ttaatatcat gcacgaaaag caaacaaact tgtgtgcttc attggatgtt cgtaccacca      540

aggaattact ggagttagtt gaagcattag gtcccaaaat ttgtttacta aaaacacatg      600

tggatatctt gactgatttt tccatggagg gcacagttaa gccgctaaag gcattatccg      660

ccaagtacaa ttttttactc ttcgaagaca gaaaatttgc tgacattggt aatacagtca      720

aattgcagta ctctgcgggt gtatacagaa tagcagaatg ggcagacatt acgaatgcac      780

acggtgtggt gggcccaggt attgttagcg gtttgaagca ggcggcagaa gaagtaacaa      840

aggaacctag aggccttttg atgttagcag aattgtcatg caagggctcc ctatctactg      900

gagaatatac taagggtact gttgacattg cgaagagcga caaagatttt gttatcggct      960

ttattgctca aagagacatg ggtggaagag atgaaggtta cgattggttg attatgacac     1020

ccggtgtggg tttagatgac aagggagacg cattgggtca acagtataga accgtggatg     1080

atgtggtctc tacaggatct gacattatta ttgttggaag aggactattt gcaaagggaa     1140

gggatgctaa ggtagagggt gaacgttaca gaaaagcagg ctgggaagca tatttgagaa     1200

gatgcggcca gcaaaactaa aaaactgtat tataagtaaa tgcatgtata ctaaactcac     1260

aaattagagc ttcaatttaa ttatatcagt tattacccta tgcggtgtga aataccgcac     1320

agatgcgtaa ggagaaaata ccgcatcagg aaattgtaaa cgttaatatt ttgttaaaat     1380

tcgcgttaaa tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa     1440

tcccttataa atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca     1500

agagtccact attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg     1560

gcgatggccc actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta     1620

aagcactaaa tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg     1680

cgaacgtggc gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa     1740

gtgtagcggt cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg     1800

gcgcgtccat tcgccattca ggctgcgcaa ctgttgggaa gggcgatcgg tgcgggcctc     1860

ttcgctatta cgccagctga attggagcga cctcatgcta tacctgagaa agcaacctga     1920

cctacaggaa agagttactc aagaataaga attttcgttt taaaacctaa gagtcacttt     1980

aaaatttgta tacacttatt ttttttataa cttatttaat aataaaaatc ataaatcata     2040

agaaattcgc ttatttagaa gtgtcaacaa cgtatctacc aacgatttga cccttttcca     2100

tcttttcgta aatttctggc aaggtagaca agccgacaac cttgattgga gacttgacca     2160

aacctctggc gaagaattgt taattaagag ctcagatctt atcgtcgtca tccttgtaat     2220

ccatcgatac tagtgcggcc gccctttagt gagggttgaa ttcgaatttt caaaaattct     2280

tacttttttt ttggatggac gcaaagaagt ttaataatca tattacatgg cattaccacc     2340

atatacatat ccatatacat atccatatct aatcttactt atatgttgtg gaaatgtaaa     2400

gagccccatt atcttagcct aaaaaaacct tctctttgga actttcagta atacgcttaa     2460

ctgctcattg ctatattgaa gtacggatta gaagccgccg agcgggtgac agccctccga     2520

aggaagactc tcctccgtgc gtcctcgtct tcaccggtcg cgttcctgaa acgcagatgt     2580

gcctcgcgcc gcactgctcc gaacaataaa gattctacaa tactagcttt tatggttatg     2640

aagaggaaaa attggcagta acctggcccc acaaaccttc aaatgaacga atcaaattaa     2700

caaccatagg atgataatgc gattagtttt ttagccttat ttctggggta attaatcagc     2760

gaagcgatga tttttgatct attaacagat atataaatgc aaaaactgca taaccacttt     2820

aactaatact ttcaacattt tcggtttgta ttacttctta ttcaaatgta ataaaagtat     2880

caacaaaaaa ttgttaatat acctctatac tttaacgtca aggagaaaaa accccggatc     2940

cgtaatacga ctcactatag ggcccgggcg tcgacatgga acagaagttg atttccgaag     3000

aagacctcga gtaagcttgg taccgcggct agctaagatc cgctctaacc gaaaaggaag     3060

gagttagaca acctgaagtc taggtcccta tttatttttt tatagttatg ttagtattaa     3120

gaacgttatt tatatttcaa atttttcttt tttttctgta cagacgcgtg tacgcatgta     3180

acattatact gaaaaccttg cttgagaagg ttttgggacg ctcgaagatc cagctgcatt     3240

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     3300

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     3360

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     3420

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     3480

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     3540

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     3600

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     3660

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     3720

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     3780

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     3840

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     3900

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     3960

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     4020

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     4080

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     4140

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     4200

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     4260

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     4320

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     4380

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     4440

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     4500

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     4560

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     4620

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     4680

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     4740

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     4800

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     4860

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     4920

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     4980

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     5040

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     5100

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     5160

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     5220

aacgaagcat ctgtgcttca ttttgtagaa caaaaatgca acgcgagagc gctaattttt     5280

caaacaaaga atctgagctg catttttaca gaacagaaat gcaacgcgaa agcgctattt     5340

taccaacgaa gaatctgtgc ttcatttttg taaaacaaaa atgcaacgcg agagcgctaa     5400

tttttcaaac aaagaatctg agctgcattt ttacagaaca gaaatgcaac gcgagagcgc     5460

tattttacca acaaagaatc tatacttctt ttttgttcta caaaaatgca tcccgagagc     5520

gctatttttc taacaaagca tcttagatta ctttttttct cctttgtgcg ctctataatg     5580

cagtctcttg ataacttttt gcactgtagg tccgttaagg ttagaagaag gctactttgg     5640

tgtctatttt ctcttccata aaaaaagcct gactccactt cccgcgttta ctgattacta     5700

gcgaagctgc gggtgcattt tttcaagata aaggcatccc cgattatatt ctataccgat     5760

gtggattgcg catactttgt gaacagaaag tgatagcgtt gatgattctt cattggtcag     5820

aaaattatga acggtttctt ctattttgtc tctatatact acgtatagga aatgtttaca     5880

ttttcgtatt gttttcgatt cactctatga atagttctta ctacaatttt tttgtctaaa     5940

gagtaatact agagataaac ataaaaaatg tagaggtcga gtttagatgc aagttcaagg     6000

agcgaaaggt ggatgggtag gttatatagg gatatagcac agagatatat agcaaagaga     6060

tacttttgag caatgtttgt ggaagcggta ttcgcaatat tttagtagct cgttacagtc     6120

cggtgcgttt ttggtttttt gaaagtgcgt cttcagagcg cttttggttt tcaaaagcgc     6180

tctgaagttc ctatactttc tagagaatag gaacttcgga ataggaactt caaagcgttt     6240

ccgaaaacga gcgcttccga aaatgcaacg cgagctgcgc acatacagct cactgttcac     6300

gtcgcaccta tatctgcgtg ttgcctgtat atatatatac atgagaagaa cggcatagtg     6360

cgtgtttatg cttaaatgcg tacttatatg cgtctattta tgtaggatga aaggtagtct     6420

agtacctcct gtgatattat cccattccat gcggggtatc gtatgcttcc ttcagcacta     6480

ccctttagct gttctatatg ctgccactcc tcaattggat tagtctcatc cttcaatgct     6540

atcatttcct ttgatattgg atcatactaa gaaaccatta ttatcatgac attaacctat     6600

aaaaataggc gtatcacgag gccctttcgt c                                    6631


<210> 24
<211> 6702
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      expression vector p427-TEF"

<400> 24
caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca       60

ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tacctcactc      120

attaggcacc ccaggcttta cactttatgc ttccggctcc tatgttgtgt ggaattgtga      180

gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaag cgcgcaatta      240

accctcacta aagggaacaa aagctggagc tcatagcttc aaaatgtttc tactcctttt      300

ttactcttcc agattttctc ggactccgcg catcgccgta ccacttcaaa acacccaagc      360

acagcatact aaatttcccc tctttcttcc tctagggtgt cgttaattac ccgtactaaa      420

ggtttggaaa agaaaaaaga gaccgcctcg tttctttttc ttcgtcgaaa aaggcaataa      480

aaatttttat cacgtttctt tttcttgaaa attttttttt ttgatttttt tctctttcga      540

tgacctccca ttgatattta agttaataaa cggtcttcaa tttctcaagt ttcagtttca      600

tttttcttgt tctattacaa ctttttttac ttcttgctca ttagaaagaa agcatagcaa      660

tctaatctaa gttttctaga actagtggat cccccgggct gcaggaattc gatatcaagc      720

ttatcgatac cgtcgacctc gagtcatgta attagttatg tcacgcttac attcacgccc      780

tccccccaca tccgctctaa ccgaaaagga aggagttaga caacctgaag tctaggtccc      840

tatttatttt tttatagtta tgttagtatt aagaacgtta tttatatttc aaatttttct      900

tttttttctg tacagacgcg tgtacgcatg taacattata ctgaaaacct tgcttgagaa      960

ggttttggga cgctcgaagg ctttaatttg cggccggtac ccaattcgcc ctatagtgag     1020

tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     1080

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     1140

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgcgac     1200

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct     1260

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg     1320

ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt     1380

gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca     1440

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga     1500

ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa     1560

gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac     1620

gcgaatttta acaaaatatt aacgtttaca atttcctgat gcggtatttt ctccttacgc     1680

atctgtgcgg tatttcacac cgcatagggt aataactgat ataattaaat tgaagctcta     1740

atttgtgagt ttagtataca tgcatttact tataatacag tttctggatg gcggcgttag     1800

tatcgaatcg acagcagtat agcgaccagc attcacatac gattgacgca tgatattact     1860

ttctgcgcac ttaacttcgc atctgggcag atgatgtcga ggcgaaaaaa aatataaatc     1920

acgctaacat ttgattaaaa tagaacaact acaatataaa aaaactatac aaatgacaag     1980

ttcttgaaaa caagaatctt tttattgtca gtactgatta gaaaaactca tcgagcatca     2040

aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt     2100

tctgtaatga aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc     2160

ggtctgcgat tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa     2220

taaggttatc aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa     2280

gcttatgcat ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat     2340

cactcgcatc aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc     2400

gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg     2460

ccagcgcatc aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg     2520

ttttgccggg gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct     2580

tgatggtcgg aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa     2640

catcattggc aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc     2700

catacaatcg atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc     2760

catataaatc agcatccatg ttggaattta atcgcggcct cgaaacgtga gtcttttcct     2820

tacccatggt tgtttatgtt cggatgtgat gtgagaactg tatcctagca agattttaaa     2880

aggaagtata tgaaagaaga acctcagtgg caaatcctaa ccttttatat ttctctacag     2940

gggcgcggcg tggggacaat tcaacgcgtc tgtgagggga gcgtttccct gctcgcaggt     3000

ctgcagcgag gagccgtaat ttttgcttcg cgccgtgcgg ccatcaaaat gtatggatgc     3060

aaatgattat acatggggat gtatgggcta aatgtacggg cgacagtcac atcatgcccc     3120

tgagctgcgc acgtcaagac tgtcaaggag ggtattctgg gccttggtat ggtgcactct     3180

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc     3240

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt     3300

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa     3360

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagta     3420

tgatccaata tcaaaggaaa tgatagcatt gaaggatgag actaatccaa ttgaggagtg     3480

gcagcatata gaacagctaa agggtagtgc tgaaggaagc atacgatacc ccgcatggaa     3540

tgggataata tcacaggagg tactagacta cctttcatcc tacataaata gacgcatata     3600

agtacgcatt taagcataaa cacgcactat gccgttcttc tcatgtatat atatatacag     3660

gcaacacgca gatataggtg cgacgtgaac agtgagctgt atgtgcgcag ctcgcgttgc     3720

attttcggaa gcgctcgttt tcggaaacgc tttgaagttc ctattccgaa gttcctattc     3780

tctagaaagt ataggaactt cagagcgctt ttgaaaacca aaagcgctct gaagacgcac     3840

tttcaaaaaa ccaaaaacgc accggactgt aacgagctac taaaatattg cgaataccgc     3900

ttccacaaac attgctcaaa agtatctctt tgctatatat ctctgtgcta tatccctata     3960

taacctaccc atccaccttt cgctccttga acttgcatct aaactcgacc tctacatttt     4020

ttatgtttat ctctagtatt actctttaga caaaaaaatt gtagtaagaa ctattcatag     4080

agtgaatcga aaacaatacg aaaatgtaaa catttcctat acgtagtata tagagacaaa     4140

atagaagaaa ccgttcataa ttttctgacc aatgaagaat catcaacgct atcactttct     4200

gttcacaaag tatgcgcaat ccacatcggt atagaatata atcggggatg cctttatctt     4260

gaaaaaatgc acccgcagct tcgctagtaa tcagtaaacg cgggaagtgg agtcaggctt     4320

tttttatgga agagaaaata gacaccaaag tagccttctt ctaaccttaa cggacctaca     4380

gtgcaaaaag ttatcaagag actgcattat agagcgcaca aaggagaaaa aaagtaatct     4440

aagatgcttt gttagaaaaa tagcgctctc gggatgcatt tttgtagaac aaaaaagaag     4500

tatagattct ttgttggtaa aatagcgctc tcgcgttgca tttctgttct gtaaaaatgc     4560

agctcagatt ctttgtttga aaaattagcg ctctcgcgtt gcatttttgt tttacaaaaa     4620

tgaagcacag attcttcgtt ggtaaaatag cgctttcgcg ttgcatttct gttctgtaaa     4680

aatgcagctc agattctttg tttgaaaaat tagcgctctc gcgttgcatt tttgttctac     4740

aaaatgaagc acagatgctt cgttcaggtg gcacttttcg gggaaatgtg cgcggaaccc     4800

ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct     4860

gataaatgct tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg     4920

cccttattcc cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg     4980

tgaaagtaaa agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc     5040

tcaacagcgg taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca     5100

cttttaaagt tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac     5160

tcggtcgccg catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa     5220

agcatcttac ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg     5280

ataacactgc ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt     5340

ttttgcacaa catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg     5400

aagccatacc aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc     5460

gcaaactatt aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga     5520

tggaggcgga taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta     5580

ttgctgataa atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc     5640

cagatggtaa gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg     5700

atgaacgaaa tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt     5760

cagaccaagt ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa     5820

ggatctaggt gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt     5880

cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt     5940

ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt     6000

tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga     6060

taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag     6120

caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata     6180

agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg     6240

gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga     6300

gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca     6360

ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa     6420

acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt     6480

tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac     6540

ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt     6600

ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga     6660

ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cc                        6702


<210> 25
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of signal peptide used in expression 
      constructs"

<400> 25
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of hinge region (from IgG1)"

<400> 26
Thr His Thr Cys Pro Pro Cys Pro 
1               5               


<210> 27
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      amino acid sequence of the CH2 and CH3 domains from the Fc 
      domain from IgG1"

<400> 27
Ala Pro Gly Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Gly Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Gly Asp Pro Gly Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Gly Val His Asn Ala Lys Thr Lys Pro Arg Gly Gly 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Gly Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Gly Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Gly Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Gly Gly Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Gly Trp Gly Ser Asn Gly Gln Pro Gly Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Gly Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 28
<211> 699
<212> PRT
<213> Homo sapiens

<400> 28
Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala 
1               5                   10                  15      


Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe 
            20                  25                  30          


Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu 
        35                  40                  45              


Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu 
    50                  55                  60                  


Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val 
65                  70                  75                  80  


Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser 
                85                  90                  95      


Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp 
            100                 105                 110         


Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly 
        115                 120                 125             


Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr 
    130                 135                 140                 


Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn 
145                 150                 155                 160 


Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro 
                165                 170                 175     


Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr 
            180                 185                 190         


Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu 
        195                 200                 205             


Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys 
    210                 215                 220                 


Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu 
225                 230                 235                 240 


Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln 
                245                 250                 255     


Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp 
            260                 265                 270         


Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr 
        275                 280                 285             


Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu 
    290                 295                 300                 


Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met 
305                 310                 315                 320 


Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr 
                325                 330                 335     


Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Val Thr Thr Ser 
            340                 345                 350         


Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met 
        355                 360                 365             


Met Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu 
    370                 375                 380                 


Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe 
385                 390                 395                 400 


Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr Lys Lys 
                405                 410                 415     


Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly Tyr Pro 
            420                 425                 430         


Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr Leu Glu 
        435                 440                 445             


Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln Asn Leu 
    450                 455                 460                 


Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys Val Asp 
465                 470                 475                 480 


Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe Tyr Ser 
                485                 490                 495     


Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln Pro Pro 
            500                 505                 510         


Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly Ile Gly 
        515                 520                 525             


Met Val Ile Gly His Glu Ile Thr His Gly Phe Phe Asp Asn Gly Arg 
    530                 535                 540                 


Asn Pro Asn Lys Asp Asp Asp Leu Val Asp Trp Trp Thr Gln Gln Ser 
545                 550                 555                 560 


Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln Tyr Gly 
                565                 570                 575     


Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly Ile Asn 
            580                 585                 590         


Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln Ala Tyr 
        595                 600                 605             


Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys Leu Leu 
    610                 615                 620                 


Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn Phe Ala 
625                 630                 635                 640 


Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn Ser Ile 
                645                 650                 655     


Lys Thr Asp Val His Ser Pro Lys Asn Phe Arg Ile Ile Gly Thr Leu 
            660                 665                 670         


Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys Asn Ser 
        675                 680                 685             


Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
    690                 695                 


<210> 29
<211> 1289
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Tyr Asp 
            580                 585                 590         


Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser Ala Ala Arg Leu 
        595                 600                 605             


Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr Asp Phe Phe Lys 
    610                 615                 620                 


Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile Pro Glu Thr Ser 
625                 630                 635                 640 


Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu Leu Glu Val Val 
                645                 650                 655     


Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp Ile Val Ala Val 
            660                 665                 670         


Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn Glu Ser Ala Ile 
        675                 680                 685             


Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu Pro Asp Ile Tyr 
    690                 695                 700                 


Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys Tyr Gly Ala Ser 
705                 710                 715                 720 


Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser Lys Tyr Gly Lys 
                725                 730                 735     


Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp Lys Asn Ser Val 
            740                 745                 750         


Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly Leu Pro Ser Arg 
        755                 760                 765             


Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala Cys Thr Ala Tyr 
    770                 775                 780                 


Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg Gln Glu Glu Arg 
785                 790                 795                 800 


Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met Asn Lys Val Met 
                805                 810                 815     


Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys Pro Glu Asp Arg 
            820                 825                 830         


Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu Ala Gln Ile Gln 
        835                 840                 845             


Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe Ser Trp Leu Asn 
    850                 855                 860                 


Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser Ile Thr Asn Glu 
865                 870                 875                 880 


Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr Lys Leu Lys Pro 
                885                 890                 895     


Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn Leu Met Ser Trp 
            900                 905                 910         


Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg Thr Tyr Lys Glu 
        915                 920                 925             


Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Val Thr Thr Ser Glu Thr 
    930                 935                 940                 


Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly Asn Met Met Asn 
945                 950                 955                 960 


Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala Gly Glu Ser Lys 
                965                 970                 975     


His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu Val Phe Ile Gln 
            980                 985                 990         


Thr Leu Asp Asp Leu Thr Trp Met  Asp Ala Glu Thr Lys  Lys Arg Ala 
        995                 1000                 1005             


Glu Glu  Lys Ala Leu Ala Ile  Lys Glu Arg Ile Gly  Tyr Pro Asp 
    1010                 1015                 1020             


Asp Ile  Val Ser Asn Asp Asn  Lys Leu Asn Asn Glu  Tyr Leu Glu 
    1025                 1030                 1035             


Leu Asn  Tyr Lys Glu Asp Glu  Tyr Phe Glu Asn Ile  Ile Gln Asn 
    1040                 1045                 1050             


Leu Lys  Phe Ser Gln Ser Lys  Gln Leu Lys Lys Leu  Arg Glu Lys 
    1055                 1060                 1065             


Val Asp  Lys Asp Glu Trp Ile  Ser Gly Ala Ala Val  Val Asn Ala 
    1070                 1075                 1080             


Phe Tyr  Ser Ser Gly Arg Asn  Gln Ile Val Phe Pro  Ala Gly Ile 
    1085                 1090                 1095             


Leu Gln  Pro Pro Phe Phe Ser  Ala Gln Gln Ser Asn  Ser Leu Asn 
    1100                 1105                 1110             


Tyr Gly  Gly Ile Gly Met Val  Ile Gly His Glu Ile  Thr His Gly 
    1115                 1120                 1125             


Phe Phe  Asp Asn Gly Arg Asn  Pro Asn Lys Asp Asp  Asp Leu Val 
    1130                 1135                 1140             


Asp Trp  Trp Thr Gln Gln Ser  Ala Ser Asn Phe Lys  Glu Gln Ser 
    1145                 1150                 1155             


Gln Cys  Met Val Tyr Gln Tyr  Gly Asn Phe Ser Trp  Asp Leu Ala 
    1160                 1165                 1170             


Gly Gly  Gln His Leu Asn Gly  Ile Asn Thr Leu Gly  Glu Asn Ile 
    1175                 1180                 1185             


Ala Asp  Asn Gly Gly Leu Gly  Gln Ala Tyr Arg Ala  Tyr Gln Asn 
    1190                 1195                 1200             


Tyr Ile  Lys Lys Asn Gly Glu  Glu Lys Leu Leu Pro  Gly Leu Asp 
    1205                 1210                 1215             


Leu Asn  His Lys Gln Leu Phe  Phe Leu Asn Phe Ala  Gln Val Trp 
    1220                 1225                 1230             


Cys Gly  Thr Tyr Arg Pro Glu  Tyr Ala Val Asn Ser  Ile Lys Thr 
    1235                 1240                 1245             


Asp Val  His Ser Pro Lys Asn  Phe Arg Ile Ile Gly  Thr Leu Gln 
    1250                 1255                 1260             


Asn Ser  Ala Glu Phe Ser Glu  Ala Phe His Cys Arg  Lys Asn Ser 
    1265                 1270                 1275             


Tyr Met  Asn Pro Glu Lys Lys  Cys Arg Val Trp 
    1280                 1285                 


<210> 30
<211> 585
<212> PRT
<213> Homo sapiens

<400> 30
Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210> 31
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Gly Gly Gly Gly Ser 
1               5   


<210> 32
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Gly Gly Gly Gly Gly Ser 
1               5       


<210> 33
<211> 43
<212> PRT
<213> Homo sapiens

<400> 33
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala Thr 
        35                  40              


<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Gly Gly Gly 
1               


<210> 35
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Gly Gly Gly Gly 
1               5   


<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      10xHis tag"

<400> 36
His His His His His His His His His His 
1               5                   10  


<210> 37
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210> 38
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              


<210> 39
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210> 40
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Cys Ser Ser Ser Ser Leu Met Asp Lys Glu Ser Val Tyr Phe Cys His 
1               5                   10                  15      


Leu Asp Ile Ile Trp 
            20      


<210> 41
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Ser Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val Tyr Phe Ser His 
1               5                   10                  15      


Leu Asp Ile Ile Trp 
            20      


<210> 42
<211> 31
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Asp Arg Val Tyr Ile His Pro Phe His Leu 
1               5                   10  


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Arg Pro Pro Gly Phe Ser Pro Phe Arg 
1               5                   


<210> 45
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210> 46
<211> 28
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Ser Ala Asn Ser Asn Pro Ala Met Ala Pro Arg Glu Arg Lys Ala Gly 
1               5                   10                  15      


Cys Lys Asn Phe Phe Trp Lys Thr Phe Thr Ser Cys 
            20                  25              


<210> 47
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210> 48
<211> 749
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (99)..(99)
<223> /replace="Asp"

<220>
<221> VARIANT
<222> (100)..(100)
<223> /replace="Ile"

<220>
<221> VARIANT
<222> (101)..(101)
<223> /replace="Leu" or "Val" or "Tyr" or "Ile"

<220>
<221> misc_feature
<222> (99)..(101)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (104)..(104)
<223> /replace="Leu" or "Met" or "Arg" or "Val" or "Trp"

<220>
<221> misc_feature
<222> (104)..(104)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (107)..(107)
<223> /replace="Asn" or "Val" or "Trp"

<220>
<221> misc_feature
<222> (107)..(107)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (195)..(195)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (195)..(195)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (206)..(206)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (206)..(206)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (211)..(211)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (211)..(211)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (214)..(214)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (214)..(214)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (217)..(217)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (217)..(217)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (219)..(219)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (220)..(220)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (219)..(220)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (224)..(224)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (224)..(224)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (227)..(227)
<223> /replace="Leu" or "Arg"

<220>
<221> VARIANT
<222> (228)..(228)
<223> /replace="Gly"

<220>
<221> VARIANT
<222> (229)..(229)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (227)..(229)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (247)..(247)
<223> /replace="Cys" or "Leu"

<220>
<221> misc_feature
<222> (247)..(247)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (287)..(287)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (287)..(287)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (292)..(292)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (292)..(292)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (323)..(323)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (323)..(323)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (346)..(346)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (346)..(346)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (376)..(376)
<223> /replace="Tyr"

<220>
<221> VARIANT
<222> (377)..(377)
<223> /replace="Phe" or "His" or "Thr" or "Tyr" or "Gly"

<220>
<221> VARIANT
<222> (378)..(378)
<223> /replace="Glu" or "Lys" or "Arg"

<220>
<221> misc_feature
<222> (376)..(378)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (380)..(380)
<223> /replace="Lys" or "Arg"

<220>
<221> VARIANT
<222> (381)..(381)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (380)..(381)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (393)..(393)
<223> /replace="Ser"

<220>
<221> VARIANT
<222> (394)..(394)
<223> /replace="Cys" or "Glu" or "Gly" or "Met" or "Pro"

<220>
<221> misc_feature
<222> (393)..(394)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (396)..(396)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (396)..(396)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (399)..(399)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (399)..(399)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (403)..(403)
<223> /replace="His" or "Leu" or "Ser"

<220>
<221> VARIANT
<222> (404)..(404)
<223> /replace="Asp" or "Phe"

<220>
<221> VARIANT
<222> (405)..(405)
<223> /replace="Thr"

<220>
<221> misc_feature
<222> (403)..(405)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (413)..(413)
<223> /replace="Asp"

<220>
<221> misc_feature
<222> (413)..(413)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (415)..(415)
<223> /replace="Ala"

<220>
<221> VARIANT
<222> (416)..(416)
<223> /replace="Arg" or "Trp"

<220>
<221> VARIANT
<222> (417)..(417)
<223> /replace="Trp"

<220>
<221> misc_feature
<222> (415)..(417)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (419)..(419)
<223> /replace="Leu" or "Met" or "Phe" or "Lys"

<220>
<221> misc_feature
<222> (419)..(419)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (422)..(422)
<223> /replace="Met"

<220>
<221> misc_feature
<222> (422)..(422)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (468)..(468)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (468)..(468)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (485)..(485)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (485)..(485)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (510)..(510)
<223> /replace="Asp" or "Gly" or "Phe" or "Arg"

<220>
<221> misc_feature
<222> (510)..(510)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (514)..(514)
<223> /replace="Lys" or "Phe"

<220>
<221> misc_feature
<222> (514)..(514)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (516)..(516)
<223> /replace="Arg"

<220>
<221> VARIANT
<222> (517)..(517)
<223> /replace="Asp" or "Phe" or "Arg" or "Trp" or "Tyr"

<220>
<221> VARIANT
<222> (518)..(518)
<223> /replace="Arg" or "Pro"

<220>
<221> misc_feature
<222> (516)..(518)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (521)..(521)
<223> /replace="Arg" or "Glu"

<220>
<221> VARIANT
<222> (522)..(522)
<223> /replace="Tyr"

<220>
<221> misc_feature
<222> (521)..(522)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (524)..(524)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (524)..(524)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (533)..(533)
<223> /replace="Phe" or "Ala" or "Arg"

<220>
<221> VARIANT
<222> (534)..(534)
<223> /replace="Cys"

<220>
<221> misc_feature
<222> (533)..(534)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (536)..(536)
<223> /replace="Gly" or "Pro" or "Arg" or "Glu" or "Trp"

<220>
<221> VARIANT
<222> (537)..(537)
<223> /replace="Glu" or "Thr"

<220>
<221> misc_feature
<222> (536)..(537)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (540)..(540)
<223> /replace="Cys" or "Glu" or "Phe" or "Gly"

<220>
<221> misc_feature
<222> (540)..(540)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (545)..(545)
<223> /replace="Ser" or "Val"

<220>
<221> VARIANT
<222> (546)..(546)
<223> /replace="Asp" or "Glu" or Ile" or "Arg" or "Trp" or "Tyr"

<220>
<221> VARIANT
<222> (547)..(547)
<223> /replace="Asp" or "Glu" or "Phe" or "Gly" or "Lys"

<220>
<221> VARIANT
<222> (548)..(548)
<223> /replace="Cys" or "Glu" or "Arg" or "Trp"

<220>
<221> misc_feature
<222> (545)..(548)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (590)..(590)
<223> /replace="Phe" or "Met" or "Trp"

<220>
<221> VARIANT
<222> (591)..(591)
<223> /replace="Glu" or "Leu"

<220>
<221> VARIANT
<222> (592)..(592)
<223> /replace="Pro"

<220>
<221> VARIANT
<222> (593)..(593)
<223> /replace="Val" or "Asp"

<220>
<221> misc_feature
<222> (590)..(593)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (596)..(596)
<223> /replace="Pro"

<220>
<221> misc_feature
<222> (596)..(596)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (600)..(600)
<223> /replace="Asp" or "Val" or "Trp"

<220>
<221> misc_feature
<222> (600)..(600)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (606)..(606)
<223> /replace="Ser"

<220>
<221> misc_feature
<222> (606)..(606)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (624)..(624)
<223> /replace="His"

<220>
<221> misc_feature
<222> (624)..(624)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (649)..(649)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (649)..(649)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (692)..(692)
<223> /replace="Met"

<220>
<221> VARIANT
<222> (693)..(693)
<223> /replace="Cys" or "Phe" or "Asn" or "Gln" or "Val" or "Leu"

<220>
<221> misc_feature
<222> (692)..(693)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotation for said positions"

<220>
<221> VARIANT
<222> (697)..(697)
<223> /replace="Gly"

<220>
<221> misc_feature
<222> (697)..(697)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (701)..(701)
<223> /replace="Gly" or "Arg"

<220>
<221> misc_feature
<222> (701)..(701)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (704)..(704)
<223> /replace="Glu" or "Gly" or "Arg" or "Trp"

<220>
<221> VARIANT
<222> (705)..(705)
<223> /replace="Arg"

<220>
<221> misc_feature
<222> (704)..(705)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (708)..(708)
<223> /replace="Lys"

<220>
<221> VARIANT
<222> (709)..(709)
<223> /replace="Lys" or "Val"

<220>
<221> VARIANT
<222> (710)..(710)
<223> /replace="Phe"

<220>
<221> misc_feature
<222> (708)..(710)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> VARIANT
<222> (712)..(712)
<223> /replace="His" or "Leu" or "Gln" or "Gly"

<220>
<221> misc_feature
<222> (712)..(712)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (714)..(714)
<223> /replace="His" or "Lys"

<220>
<221> misc_feature
<222> (714)..(714)
<223> /note="Residue given in the sequence has no preference 
      with respect to those in the annotation for said position"

<220>
<221> VARIANT
<222> (735)..(735)
<223> /replace="His"

<220>
<221> misc_feature
<222> (735)..(735)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220>
<221> VARIANT
<222> (745)..(745)
<223> /replace="Asn"

<220>
<221> misc_feature
<222> (745)..(745)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotation for said position"

<220> 
<221> misc_feature
<222> (1)..(749)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 48
Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys 
1               5                   10                  15      


Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val 
            20                  25                  30          


Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr 
        35                  40                  45              


Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser 
    50                  55                  60                  


Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr 
65                  70                  75                  80  


Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile 
                85                  90                  95      


Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu 
            100                 105                 110         


Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp 
        115                 120                 125             


Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn 
    130                 135                 140                 


Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu 
145                 150                 155                 160 


Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys 
                165                 170                 175     


Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser 
            180                 185                 190         


Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp 
        195                 200                 205             


Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly 
    210                 215                 220                 


Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala 
225                 230                 235                 240 


Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg 
                245                 250                 255     


Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met 
            260                 265                 270         


Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys 
        275                 280                 285             


Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu 
    290                 295                 300                 


Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe 
305                 310                 315                 320 


Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser 
                325                 330                 335     


Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr 
            340                 345                 350         


Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn 
        355                 360                 365             


Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg 
    370                 375                 380                 


Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr 
385                 390                 395                 400 


Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly 
                405                 410                 415     


Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala 
            420                 425                 430         


Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu 
        435                 440                 445             


Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr 
    450                 455                 460                 


Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly 
465                 470                 475                 480 


Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr 
                485                 490                 495     


Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln 
            500                 505                 510         


Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys 
        515                 520                 525             


Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe 
    530                 535                 540                 


Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln 
545                 550                 555                 560 


Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly 
                565                 570                 575     


Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn 
            580                 585                 590         


Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln 
        595                 600                 605             


Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln 
    610                 615                 620                 


Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly 
625                 630                 635                 640 


Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln 
                645                 650                 655     


Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys 
            660                 665                 670         


Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn 
        675                 680                 685             


Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn 
    690                 695                 700                 


Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly 
705                 710                 715                 720 


Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys 
                725                 730                 735     


Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 


<210> 49
<211> 749
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> MOD_RES
<222> (399)..(399)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (714)..(714)
<223> Any amino acid

<220> 
<221> misc_feature
<222> (1)..(749)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 49
Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys 
1               5                   10                  15      


Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val 
            20                  25                  30          


Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr 
        35                  40                  45              


Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser 
    50                  55                  60                  


Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr 
65                  70                  75                  80  


Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile 
                85                  90                  95      


Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu 
            100                 105                 110         


Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp 
        115                 120                 125             


Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn 
    130                 135                 140                 


Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu 
145                 150                 155                 160 


Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys 
                165                 170                 175     


Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser 
            180                 185                 190         


Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp 
        195                 200                 205             


Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly 
    210                 215                 220                 


Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala 
225                 230                 235                 240 


Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg 
                245                 250                 255     


Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met 
            260                 265                 270         


Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys 
        275                 280                 285             


Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu 
    290                 295                 300                 


Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe 
305                 310                 315                 320 


Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser 
                325                 330                 335     


Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr 
            340                 345                 350         


Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn 
        355                 360                 365             


Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg 
    370                 375                 380                 


Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Xaa Thr 
385                 390                 395                 400 


Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly 
                405                 410                 415     


Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala 
            420                 425                 430         


Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu 
        435                 440                 445             


Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr 
    450                 455                 460                 


Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly 
465                 470                 475                 480 


Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr 
                485                 490                 495     


Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln 
            500                 505                 510         


Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys 
        515                 520                 525             


Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe 
    530                 535                 540                 


Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln 
545                 550                 555                 560 


Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly 
                565                 570                 575     


Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn 
            580                 585                 590         


Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln 
        595                 600                 605             


Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln 
    610                 615                 620                 


Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly 
625                 630                 635                 640 


Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln 
                645                 650                 655     


Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys 
            660                 665                 670         


Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn 
        675                 680                 685             


Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn 
    690                 695                 700                 


Ser Ile Lys Thr Asp Val His Ser Pro Xaa Asn Phe Arg Ile Ile Gly 
705                 710                 715                 720 


Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys 
                725                 730                 735     


Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 


<210> 50
<211> 749
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (399)..(399)
<223> /replace="Val"

<220>
<221> misc_feature
<222> (399)..(399)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotations for said position"

<220>
<221> VARIANT
<222> (714)..(714)
<223> /replace="Lys"

<220>
<221> misc_feature
<222> (714)..(714)
<223> /note="Residue given in the sequence has no preference 
      with respect to that in the annotations for said position"

<400> 50
Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro Lys 
1               5                   10                  15      


Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser Val 
            20                  25                  30          


Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu Tyr 
        35                  40                  45              


Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys Ser 
    50                  55                  60                  


Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys Thr 
65                  70                  75                  80  


Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val Ile 
                85                  90                  95      


Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp Glu 
            100                 105                 110         


Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu Asp 
        115                 120                 125             


Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile Asn 
    130                 135                 140                 


Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu Leu 
145                 150                 155                 160 


Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln Lys 
                165                 170                 175     


Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn Ser 
            180                 185                 190         


Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp Asp 
        195                 200                 205             


Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu Gly 
    210                 215                 220                 


Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu Ala 
225                 230                 235                 240 


Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile Arg 
                245                 250                 255     


Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu Met 
            260                 265                 270         


Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala Lys 
        275                 280                 285             


Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr Leu 
    290                 295                 300                 


Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro Phe 
305                 310                 315                 320 


Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile Ser 
                325                 330                 335     


Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu Thr 
            340                 345                 350         


Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln Asn 
        355                 360                 365             


Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser Arg 
    370                 375                 380                 


Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly Thr 
385                 390                 395                 400 


Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn Gly 
                405                 410                 415     


Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe Ala 
            420                 425                 430         


Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg Glu 
        435                 440                 445             


Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu Thr 
    450                 455                 460                 


Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile Gly 
465                 470                 475                 480 


Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu Tyr 
                485                 490                 495     


Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile Gln 
            500                 505                 510         


Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu Lys 
        515                 520                 525             


Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala Phe 
    530                 535                 540                 


Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu Gln 
545                 550                 555                 560 


Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly Gly 
                565                 570                 575     


Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp Asn 
            580                 585                 590         


Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr Gln 
        595                 600                 605             


Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr Gln 
    610                 615                 620                 


Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn Gly 
625                 630                 635                 640 


Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly Gln 
                645                 650                 655     


Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu Lys 
            660                 665                 670         


Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu Asn 
        675                 680                 685             


Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val Asn 
    690                 695                 700                 


Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile Gly 
705                 710                 715                 720 


Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg Lys 
                725                 730                 735     


Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 


