                         SEQUENCE LISTING

<110>  JJK MEDICAL LTD
 
<120>  NEW MEDIUM, DEVICES AND METHODS

<130>  21051381

<150>  EP10166799.6
<151>  2010-06-22

<150>  US 61/357,231
<151>  2010-06-22

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  4655
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Arg Gly Pro Ala Ala Val Ala Cys Thr Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Ala Cys Leu Ala Pro Ala Ser Gly Gln Glu Cys Asp Ser Ala His 
            20                  25                  30          


Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala Asp Trp Arg Cys Asp 
        35                  40                  45              


Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu Ile Gly Cys Ala Val 
    50                  55                  60                  


Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln Ser Glu Gly Gln Cys 
65                  70                  75                  80  


Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln Asp Cys Asp Asp Gly 
                85                  90                  95      


Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr Cys Ser Ser His Gln 
            100                 105                 110         


Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser Glu Tyr Arg Cys Asp 
        115                 120                 125             


His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu Asn Asp Cys Gln Tyr 
    130                 135                 140                 


Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly Ala Cys Tyr Asn Thr 
145                 150                 155                 160 


Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg Asp Ser Ser Asp Glu 
                165                 170                 175     


Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu Phe Ser Cys Gly Asn 
            180                 185                 190         


Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp His Asp Asn Asp Cys 
        195                 200                 205             


Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr Pro Thr Cys Gly Gly 
    210                 215                 220                 


Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln Asn Trp Val 
225                 230                 235                 240 


Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu Asp Gly Cys 
                245                 250                 255     


Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg Glu Trp Ser 
            260                 265                 270         


Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val Cys Asp Gly 
        275                 280                 285             


Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr Ser Thr Gly 
    290                 295                 300                 


Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys Gln Tyr Gln 
305                 310                 315                 320 


Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro Pro Gly Tyr 
                325                 330                 335     


Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe Asp Asp Cys 
            340                 345                 350         


Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg Pro Gly Arg 
        355                 360                 365             


His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg Gly Gln Tyr 
    370                 375                 380                 


Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile Phe Ser Asn 
385                 390                 395                 400 


Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser Phe Arg Ile 
                405                 410                 415     


Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val Ala Phe His 
            420                 425                 430         


Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln Asn Lys Val 
        435                 440                 445             


Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val Leu Asn Val 
    450                 455                 460                 


Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val Asn Asn Lys 
465                 470                 475                 480 


Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met Val Asn Leu 
                485                 490                 495     


Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu Gly His Pro 
            500                 505                 510         


Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe Phe Ser Asp 
        515                 520                 525             


Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala Phe Met Asp 
    530                 535                 540                 


Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly Trp Pro Ala 
545                 550                 555                 560 


Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp Val Asp Ser 
                565                 570                 575     


Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile Gln Arg Lys 
            580                 585                 590         


Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe Gly Val Ser 
        595                 600                 605             


Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys Met Ala Val 
    610                 615                 620                 


Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val Tyr Tyr Gln 
625                 630                 635                 640 


Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser Leu Arg Gln 
                645                 650                 655     


Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly Cys Glu Gln 
            660                 665                 670         


Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu Gly Phe Arg 
        675                 680                 685             


Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu Arg His Cys 
    690                 695                 700                 


Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val Ala Ile Arg 
705                 710                 715                 720 


Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met Val Pro Val 
                725                 730                 735     


Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp Ala Gln Asp 
            740                 745                 750         


Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile Phe Lys Gln 
        755                 760                 765             


Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn Arg Val Glu 
    770                 775                 780                 


Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn Leu Tyr Trp 
785                 790                 795                 800 


Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu Ala Asp Lys 
                805                 810                 815     


Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg Ser Val Val 
            820                 825                 830         


Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp Phe Arg Pro 
        835                 840                 845             


Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu Leu Pro Val 
    850                 855                 860                 


Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile Asp Trp Ala 
865                 870                 875                 880 


Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys Ile Glu His 
                885                 890                 895     


Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly His Ile Glu Gln 
            900                 905                 910         


Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu His Leu Phe Phe 
        915                 920                 925             


Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg Lys Ala Asp Gly 
    930                 935                 940                 


Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr Ile Leu His Leu 
945                 950                 955                 960 


Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn Ala Cys Asn Gln 
                965                 970                 975     


Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys Phe Pro Val Pro 
            980                 985                 990         


Asn Phe Gln Arg Val Cys Gly Cys  Pro Tyr Gly Met Arg  Leu Ala Ser 
        995                 1000                 1005             


Asn His  Leu Thr Cys Glu Gly  Asp Pro Thr Asn Glu  Pro Pro Thr 
    1010                 1015                 1020             


Glu Gln  Cys Gly Leu Phe Ser  Phe Pro Cys Lys Asn  Gly Arg Cys 
    1025                 1030                 1035             


Val Pro  Asn Tyr Tyr Leu Cys  Asp Gly Val Asp Asp  Cys His Asp 
    1040                 1045                 1050             


Asn Ser  Asp Glu Gln Leu Cys  Gly Thr Leu Asn Asn  Thr Cys Ser 
    1055                 1060                 1065             


Ser Ser  Ala Phe Thr Cys Gly  His Gly Glu Cys Ile  Pro Ala His 
    1070                 1075                 1080             


Trp Arg  Cys Asp Lys Arg Asn  Asp Cys Val Asp Gly  Ser Asp Glu 
    1085                 1090                 1095             


His Asn  Cys Pro Thr His Ala  Pro Ala Ser Cys Leu  Asp Thr Gln 
    1100                 1105                 1110             


Tyr Thr  Cys Asp Asn His Gln  Cys Ile Ser Lys Asn  Trp Val Cys 
    1115                 1120                 1125             


Asp Thr  Asp Asn Asp Cys Gly  Asp Gly Ser Asp Glu  Lys Asn Cys 
    1130                 1135                 1140             


Asn Ser  Thr Glu Thr Cys Gln  Pro Ser Gln Phe Asn  Cys Pro Asn 
    1145                 1150                 1155             


His Arg  Cys Ile Asp Leu Ser  Phe Val Cys Asp Gly  Asp Lys Asp 
    1160                 1165                 1170             


Cys Val  Asp Gly Ser Asp Glu  Val Gly Cys Val Leu  Asn Cys Thr 
    1175                 1180                 1185             


Ala Ser  Gln Phe Lys Cys Ala  Ser Gly Asp Lys Cys  Ile Gly Val 
    1190                 1195                 1200             


Thr Asn  Arg Cys Asp Gly Val  Phe Asp Cys Ser Asp  Asn Ser Asp 
    1205                 1210                 1215             


Glu Ala  Gly Cys Pro Thr Arg  Pro Pro Gly Met Cys  His Ser Asp 
    1220                 1225                 1230             


Glu Phe  Gln Cys Gln Glu Asp  Gly Ile Cys Ile Pro  Asn Phe Trp 
    1235                 1240                 1245             


Glu Cys  Asp Gly His Pro Asp  Cys Leu Tyr Gly Ser  Asp Glu His 
    1250                 1255                 1260             


Asn Ala  Cys Val Pro Lys Thr  Cys Pro Ser Ser Tyr  Phe His Cys 
    1265                 1270                 1275             


Asp Asn  Gly Asn Cys Ile His  Arg Ala Trp Leu Cys  Asp Arg Asp 
    1280                 1285                 1290             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Lys Asp Cys  Pro Thr Gln 
    1295                 1300                 1305             


Pro Phe  Arg Cys Pro Ser Trp  Gln Trp Gln Cys Leu  Gly His Asn 
    1310                 1315                 1320             


Ile Cys  Val Asn Leu Ser Val  Val Cys Asp Gly Ile  Phe Asp Cys 
    1325                 1330                 1335             


Pro Asn  Gly Thr Asp Glu Ser  Pro Leu Cys Asn Gly  Asn Ser Cys 
    1340                 1345                 1350             


Ser Asp  Phe Asn Gly Gly Cys  Thr His Glu Cys Val  Gln Glu Pro 
    1355                 1360                 1365             


Phe Gly  Ala Lys Cys Leu Cys  Pro Leu Gly Phe Leu  Leu Ala Asn 
    1370                 1375                 1380             


Asp Ser  Lys Thr Cys Glu Asp  Ile Asp Glu Cys Asp  Ile Leu Gly 
    1385                 1390                 1395             


Ser Cys  Ser Gln His Cys Tyr  Asn Met Arg Gly Ser  Phe Arg Cys 
    1400                 1405                 1410             


Ser Cys  Asp Thr Gly Tyr Met  Leu Glu Ser Asp Gly  Arg Thr Cys 
    1415                 1420                 1425             


Lys Val  Thr Ala Ser Glu Ser  Leu Leu Leu Leu Val  Ala Ser Gln 
    1430                 1435                 1440             


Asn Lys  Ile Ile Ala Asp Ser  Val Thr Ser Gln Val  His Asn Ile 
    1445                 1450                 1455             


Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile Val Ala  Val Asp Phe 
    1460                 1465                 1470             


Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser Asp Ala  Thr Gln Gly 
    1475                 1480                 1485             


Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr Asp Arg  Arg Val Val 
    1490                 1495                 1500             


Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr Ile Ala  Ile Asp Trp 
    1505                 1510                 1515             


Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr Ala Leu  Glu Thr Ile 
    1520                 1525                 1530             


Glu Val  Ser Lys Ile Asp Gly  Ser His Arg Thr Val  Leu Ile Ser 
    1535                 1540                 1545             


Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala Leu Asp  Pro Arg Met 
    1550                 1555                 1560             


Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp Gly His  His Pro Arg 
    1565                 1570                 1575             


Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met Arg Thr  Val Ile Val 
    1580                 1585                 1590             


Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu Thr Ile  Asp Tyr Pro 
    1595                 1600                 1605             


Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr Leu Asp  Tyr Met Asp 
    1610                 1615                 1620             


Phe Cys  Asp Tyr Asn Gly His  His Arg Arg Gln Val  Ile Ala Ser 
    1625                 1630                 1635             


Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu Thr Leu  Phe Glu Asp 
    1640                 1645                 1650             


Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg Arg Val  Met Arg Ala 
    1655                 1660                 1665             


Asn Lys  Trp His Gly Gly Asn  Gln Ser Val Val Met  Tyr Asn Ile 
    1670                 1675                 1680             


Gln Trp  Pro Leu Gly Ile Val  Ala Val His Pro Ser  Lys Gln Pro 
    1685                 1690                 1695             


Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg Cys Ser  His Leu Cys 
    1700                 1705                 1710             


Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr Ser Cys  Val Cys Pro 
    1715                 1720                 1725             


Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu Asn Cys  Leu Arg Asp 
    1730                 1735                 1740             


Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln His Ile  Ile Phe Gly 
    1745                 1750                 1755             


Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn Asp Ala  Met Val Pro 
    1760                 1765                 1770             


Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val Glu Phe  Asp Asp Ala 
    1775                 1780                 1785             


Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro Gly Glu  Ile His Arg 
    1790                 1795                 1800             


Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val Phe Ala  Ser Ile Ser 
    1805                 1810                 1815             


Met Val  Gly Pro Ser Met Asn  Leu Ala Leu Asp Trp  Ile Ser Arg 
    1820                 1825                 1830             


Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln Ser Ile  Glu Val Leu 
    1835                 1840                 1845             


Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys Thr Leu  Ile Ala Asn 
    1850                 1855                 1860             


Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro Ile Gly  Ile Thr Val 
    1865                 1870                 1875             


Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser Asp Gln  Gly Thr Asp 
    1880                 1885                 1890             


Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala Asn Met  Asp Gly Thr 
    1895                 1900                 1905             


Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu Glu His  Leu Glu Cys 
    1910                 1915                 1920             


Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu Tyr Trp  Ala Val Thr 
    1925                 1930                 1935             


Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val Asp Gly  Thr Asp Arg 
    1940                 1945                 1950             


Met Ile  Leu Val His Gln Leu  Ser His Pro Trp Gly  Ile Ala Val 
    1955                 1960                 1965             


His Asp  Ser Phe Leu Tyr Tyr  Thr Asp Glu Gln Tyr  Glu Val Ile 
    1970                 1975                 1980             


Glu Arg  Val Asp Lys Ala Thr  Gly Ala Asn Lys Ile  Val Leu Arg 
    1985                 1990                 1995             


Asp Asn  Val Pro Asn Leu Arg  Gly Leu Gln Val Tyr  His Arg Arg 
    2000                 2005                 2010             


Asn Ala  Ala Glu Ser Ser Asn  Gly Cys Ser Asn Asn  Met Asn Ala 
    2015                 2020                 2025             


Cys Gln  Gln Ile Cys Leu Pro  Val Pro Gly Gly Leu  Phe Ser Cys 
    2030                 2035                 2040             


Ala Cys  Ala Thr Gly Phe Lys  Leu Asn Pro Asp Asn  Arg Ser Cys 
    2045                 2050                 2055             


Ser Pro  Tyr Asn Ser Phe Ile  Val Val Ser Met Leu  Ser Ala Ile 
    2060                 2065                 2070             


Arg Gly  Phe Ser Leu Glu Leu  Ser Asp His Ser Glu  Thr Met Val 
    2075                 2080                 2085             


Pro Val  Ala Gly Gln Gly Arg  Asn Ala Leu His Val  Asp Val Asp 
    2090                 2095                 2100             


Val Ser  Ser Gly Phe Ile Tyr  Trp Cys Asp Phe Ser  Ser Ser Val 
    2105                 2110                 2115             


Ala Ser  Asp Asn Ala Ile Arg  Arg Ile Lys Pro Asp  Gly Ser Ser 
    2120                 2125                 2130             


Leu Met  Asn Ile Val Thr His  Gly Ile Gly Glu Asn  Gly Val Arg 
    2135                 2140                 2145             


Gly Ile  Ala Val Asp Trp Val  Ala Gly Asn Leu Tyr  Phe Thr Asn 
    2150                 2155                 2160             


Ala Phe  Val Ser Glu Thr Leu  Ile Glu Val Leu Arg  Ile Asn Thr 
    2165                 2170                 2175             


Thr Tyr  Arg Arg Val Leu Leu  Lys Val Thr Val Asp  Met Pro Arg 
    2180                 2185                 2190             


His Ile  Val Val Asp Pro Lys  Asn Arg Tyr Leu Phe  Trp Ala Asp 
    2195                 2200                 2205             


Tyr Gly  Gln Arg Pro Lys Ile  Glu Arg Ser Phe Leu  Asp Cys Thr 
    2210                 2215                 2220             


Asn Arg  Thr Val Leu Val Ser  Glu Gly Ile Val Thr  Pro Arg Gly 
    2225                 2230                 2235             


Leu Ala  Val Asp Arg Ser Asp  Gly Tyr Val Tyr Trp  Val Asp Asp 
    2240                 2245                 2250             


Ser Leu  Asp Ile Ile Ala Arg  Ile Arg Ile Asn Gly  Glu Asn Ser 
    2255                 2260                 2265             


Glu Val  Ile Arg Tyr Gly Ser  Arg Tyr Pro Thr Pro  Tyr Gly Ile 
    2270                 2275                 2280             


Thr Val  Phe Glu Asn Ser Ile  Ile Trp Val Asp Arg  Asn Leu Lys 
    2285                 2290                 2295             


Lys Ile  Phe Gln Ala Ser Lys  Glu Pro Glu Asn Thr  Glu Pro Pro 
    2300                 2305                 2310             


Thr Val  Ile Arg Asp Asn Ile  Asn Trp Leu Arg Asp  Val Thr Ile 
    2315                 2320                 2325             


Phe Asp  Lys Gln Val Gln Pro  Arg Ser Pro Ala Glu  Val Asn Asn 
    2330                 2335                 2340             


Asn Pro  Cys Leu Glu Asn Asn  Gly Gly Cys Ser His  Leu Cys Phe 
    2345                 2350                 2355             


Ala Leu  Pro Gly Leu His Thr  Pro Lys Cys Asp Cys  Ala Phe Gly 
    2360                 2365                 2370             


Thr Leu  Gln Ser Asp Gly Lys  Asn Cys Ala Ile Ser  Thr Glu Asn 
    2375                 2380                 2385             


Phe Leu  Ile Phe Ala Leu Ser  Asn Ser Leu Arg Ser  Leu His Leu 
    2390                 2395                 2400             


Asp Pro  Glu Asn His Ser Pro  Pro Phe Gln Thr Ile  Asn Val Glu 
    2405                 2410                 2415             


Arg Thr  Val Met Ser Leu Asp  Tyr Asp Ser Val Ser  Asp Arg Ile 
    2420                 2425                 2430             


Tyr Phe  Thr Gln Asn Leu Ala  Ser Gly Val Gly Gln  Ile Ser Tyr 
    2435                 2440                 2445             


Ala Thr  Leu Ser Ser Gly Ile  His Thr Pro Thr Val  Ile Ala Ser 
    2450                 2455                 2460             


Gly Ile  Gly Thr Ala Asp Gly  Ile Ala Phe Asp Trp  Ile Thr Arg 
    2465                 2470                 2475             


Arg Ile  Tyr Tyr Ser Asp Tyr  Leu Asn Gln Met Ile  Asn Ser Met 
    2480                 2485                 2490             


Ala Glu  Asp Gly Ser Asn Arg  Thr Val Ile Ala Arg  Val Pro Lys 
    2495                 2500                 2505             


Pro Arg  Ala Ile Val Leu Asp  Pro Cys Gln Gly Tyr  Leu Tyr Trp 
    2510                 2515                 2520             


Ala Asp  Trp Asp Thr His Ala  Lys Ile Glu Arg Ala  Thr Leu Gly 
    2525                 2530                 2535             


Gly Asn  Phe Arg Val Pro Ile  Val Asn Ser Ser Leu  Val Met Pro 
    2540                 2545                 2550             


Ser Gly  Leu Thr Leu Asp Tyr  Glu Glu Asp Leu Leu  Tyr Trp Val 
    2555                 2560                 2565             


Asp Ala  Ser Leu Gln Arg Ile  Glu Arg Ser Thr Leu  Thr Gly Val 
    2570                 2575                 2580             


Asp Arg  Glu Val Ile Val Asn  Ala Ala Val His Ala  Phe Gly Leu 
    2585                 2590                 2595             


Thr Leu  Tyr Gly Gln Tyr Ile  Tyr Trp Thr Asp Leu  Tyr Thr Gln 
    2600                 2605                 2610             


Arg Ile  Tyr Arg Ala Asn Lys  Tyr Asp Gly Ser Gly  Gln Ile Ala 
    2615                 2620                 2625             


Met Thr  Thr Asn Leu Leu Ser  Gln Pro Arg Gly Ile  Asn Thr Val 
    2630                 2635                 2640             


Val Lys  Asn Gln Lys Gln Gln  Cys Asn Asn Pro Cys  Glu Gln Phe 
    2645                 2650                 2655             


Asn Gly  Gly Cys Ser His Ile  Cys Ala Pro Gly Pro  Asn Gly Ala 
    2660                 2665                 2670             


Glu Cys  Gln Cys Pro His Glu  Gly Asn Trp Tyr Leu  Ala Asn Asn 
    2675                 2680                 2685             


Arg Lys  His Cys Ile Val Asp  Asn Gly Glu Arg Cys  Gly Ala Ser 
    2690                 2695                 2700             


Ser Phe  Thr Cys Ser Asn Gly  Arg Cys Ile Ser Glu  Glu Trp Lys 
    2705                 2710                 2715             


Cys Asp  Asn Asp Asn Asp Cys  Gly Asp Gly Ser Asp  Glu Met Glu 
    2720                 2725                 2730             


Ser Val  Cys Ala Leu His Thr  Cys Ser Pro Thr Ala  Phe Thr Cys 
    2735                 2740                 2745             


Ala Asn  Gly Arg Cys Val Gln  Tyr Ser Tyr Arg Cys  Asp Tyr Tyr 
    2750                 2755                 2760             


Asn Asp  Cys Gly Asp Gly Ser  Asp Glu Ala Gly Cys  Leu Phe Arg 
    2765                 2770                 2775             


Asp Cys  Asn Ala Thr Thr Glu  Phe Met Cys Asn Asn  Arg Arg Cys 
    2780                 2785                 2790             


Ile Pro  Arg Glu Phe Ile Cys  Asn Gly Val Asp Asn  Cys His Asp 
    2795                 2800                 2805             


Asn Asn  Thr Ser Asp Glu Lys  Asn Cys Pro Asp Arg  Thr Cys Gln 
    2810                 2815                 2820             


Ser Gly  Tyr Thr Lys Cys His  Asn Ser Asn Ile Cys  Ile Pro Arg 
    2825                 2830                 2835             


Val Tyr  Leu Cys Asp Gly Asp  Asn Asp Cys Gly Asp  Asn Ser Asp 
    2840                 2845                 2850             


Glu Asn  Pro Thr Tyr Cys Thr  Thr His Thr Cys Ser  Ser Ser Glu 
    2855                 2860                 2865             


Phe Gln  Cys Ala Ser Gly Arg  Cys Ile Pro Gln His  Trp Tyr Cys 
    2870                 2875                 2880             


Asp Gln  Glu Thr Asp Cys Phe  Asp Ala Ser Asp Glu  Pro Ala Ser 
    2885                 2890                 2895             


Cys Gly  His Ser Glu Arg Thr  Cys Leu Ala Asp Glu  Phe Lys Cys 
    2900                 2905                 2910             


Asp Gly  Gly Arg Cys Ile Pro  Ser Glu Trp Ile Cys  Asp Gly Asp 
    2915                 2920                 2925             


Asn Asp  Cys Gly Asp Met Ser  Asp Glu Asp Lys Arg  His Gln Cys 
    2930                 2935                 2940             


Gln Asn  Gln Asn Cys Ser Asp  Ser Glu Phe Leu Cys  Val Asn Asp 
    2945                 2950                 2955             


Arg Pro  Pro Asp Arg Arg Cys  Ile Pro Gln Ser Trp  Val Cys Asp 
    2960                 2965                 2970             


Gly Asp  Val Asp Cys Thr Asp  Gly Tyr Asp Glu Asn  Gln Asn Cys 
    2975                 2980                 2985             


Thr Arg  Arg Thr Cys Ser Glu  Asn Glu Phe Thr Cys  Gly Tyr Gly 
    2990                 2995                 3000             


Leu Cys  Ile Pro Lys Ile Phe  Arg Cys Asp Arg His  Asn Asp Cys 
    3005                 3010                 3015             


Gly Asp  Tyr Ser Asp Glu Arg  Gly Cys Leu Tyr Gln  Thr Cys Gln 
    3020                 3025                 3030             


Gln Asn  Gln Phe Thr Cys Gln  Asn Gly Arg Cys Ile  Ser Lys Thr 
    3035                 3040                 3045             


Phe Val  Cys Asp Glu Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3050                 3055                 3060             


Leu Met  His Leu Cys His Thr  Pro Glu Pro Thr Cys  Pro Pro His 
    3065                 3070                 3075             


Glu Phe  Lys Cys Asp Asn Gly  Arg Cys Ile Glu Met  Met Lys Leu 
    3080                 3085                 3090             


Cys Asn  His Leu Asp Asp Cys  Leu Asp Asn Ser Asp  Glu Lys Gly 
    3095                 3100                 3105             


Cys Gly  Ile Asn Glu Cys His  Asp Pro Ser Ile Ser  Gly Cys Asp 
    3110                 3115                 3120             


His Asn  Cys Thr Asp Thr Leu  Thr Ser Phe Tyr Cys  Ser Cys Arg 
    3125                 3130                 3135             


Pro Gly  Tyr Lys Leu Met Ser  Asp Lys Arg Thr Cys  Val Asp Ile 
    3140                 3145                 3150             


Asp Glu  Cys Thr Glu Met Pro  Phe Val Cys Ser Gln  Lys Cys Glu 
    3155                 3160                 3165             


Asn Val  Ile Gly Ser Tyr Ile  Cys Lys Cys Ala Pro  Gly Tyr Leu 
    3170                 3175                 3180             


Arg Glu  Pro Asp Gly Lys Thr  Cys Arg Gln Asn Ser  Asn Ile Glu 
    3185                 3190                 3195             


Pro Tyr  Leu Ile Phe Ser Asn  Arg Tyr Tyr Leu Arg  Asn Leu Thr 
    3200                 3205                 3210             


Ile Asp  Gly Tyr Phe Tyr Ser  Leu Ile Leu Glu Gly  Leu Asp Asn 
    3215                 3220                 3225             


Val Val  Ala Leu Asp Phe Asp  Arg Val Glu Lys Arg  Leu Tyr Trp 
    3230                 3235                 3240             


Ile Asp  Thr Gln Arg Gln Val  Ile Glu Arg Met Phe  Leu Asn Lys 
    3245                 3250                 3255             


Thr Asn  Lys Glu Thr Ile Ile  Asn His Arg Leu Pro  Ala Ala Glu 
    3260                 3265                 3270             


Ser Leu  Ala Val Asp Trp Val  Ser Arg Lys Leu Tyr  Trp Leu Asp 
    3275                 3280                 3285             


Ala Arg  Leu Asp Gly Leu Phe  Val Ser Asp Leu Asn  Gly Gly His 
    3290                 3295                 3300             


Arg Arg  Met Leu Ala Gln His  Cys Val Asp Ala Asn  Asn Thr Phe 
    3305                 3310                 3315             


Cys Phe  Asp Asn Pro Arg Gly  Leu Ala Leu His Pro  Gln Tyr Gly 
    3320                 3325                 3330             


Tyr Leu  Tyr Trp Ala Asp Trp  Gly His Arg Ala Tyr  Ile Gly Arg 
    3335                 3340                 3345             


Val Gly  Met Asp Gly Thr Asn  Lys Ser Val Ile Ile  Ser Thr Lys 
    3350                 3355                 3360             


Leu Glu  Trp Pro Asn Gly Ile  Thr Ile Asp Tyr Thr  Asn Asp Leu 
    3365                 3370                 3375             


Leu Tyr  Trp Ala Asp Ala His  Leu Gly Tyr Ile Glu  Tyr Ser Asp 
    3380                 3385                 3390             


Leu Glu  Gly His His Arg His  Thr Val Tyr Asp Gly  Ala Leu Pro 
    3395                 3400                 3405             


His Pro  Phe Ala Ile Thr Ile  Phe Glu Asp Thr Ile  Tyr Trp Thr 
    3410                 3415                 3420             


Asp Trp  Asn Thr Arg Thr Val  Glu Lys Gly Asn Lys  Tyr Asp Gly 
    3425                 3430                 3435             


Ser Asn  Arg Gln Thr Leu Val  Asn Thr Thr His Arg  Pro Phe Asp 
    3440                 3445                 3450             


Ile His  Val Tyr His Pro Tyr  Arg Gln Pro Ile Val  Ser Asn Pro 
    3455                 3460                 3465             


Cys Gly  Thr Asn Asn Gly Gly  Cys Ser His Leu Cys  Leu Ile Lys 
    3470                 3475                 3480             


Pro Gly  Gly Lys Gly Phe Thr  Cys Glu Cys Pro Asp  Asp Phe Arg 
    3485                 3490                 3495             


Thr Leu  Gln Leu Ser Gly Ser  Thr Tyr Cys Met Pro  Met Cys Ser 
    3500                 3505                 3510             


Ser Thr  Gln Phe Leu Cys Ala  Asn Asn Glu Lys Cys  Ile Pro Ile 
    3515                 3520                 3525             


Trp Trp  Lys Cys Asp Gly Gln  Lys Asp Cys Ser Asp  Gly Ser Asp 
    3530                 3535                 3540             


Glu Leu  Ala Leu Cys Pro Gln  Arg Phe Cys Arg Leu  Gly Gln Phe 
    3545                 3550                 3555             


Gln Cys  Ser Asp Gly Asn Cys  Thr Ser Pro Gln Thr  Leu Cys Asn 
    3560                 3565                 3570             


Ala His  Gln Asn Cys Pro Asp  Gly Ser Asp Glu Asp  Arg Leu Leu 
    3575                 3580                 3585             


Cys Glu  Asn His His Cys Asp  Ser Asn Glu Trp Gln  Cys Ala Asn 
    3590                 3595                 3600             


Lys Arg  Cys Ile Pro Glu Ser  Trp Gln Cys Asp Thr  Phe Asn Asp 
    3605                 3610                 3615             


Cys Glu  Asp Asn Ser Asp Glu  Asp Ser Ser His Cys  Ala Ser Arg 
    3620                 3625                 3630             


Thr Cys  Arg Pro Gly Gln Phe  Arg Cys Ala Asn Gly  Arg Cys Ile 
    3635                 3640                 3645             


Pro Gln  Ala Trp Lys Cys Asp  Val Asp Asn Asp Cys  Gly Asp His 
    3650                 3655                 3660             


Ser Asp  Glu Pro Ile Glu Glu  Cys Met Ser Ser Ala  His Leu Cys 
    3665                 3670                 3675             


Asp Asn  Phe Thr Glu Phe Ser  Cys Lys Thr Asn Tyr  Arg Cys Ile 
    3680                 3685                 3690             


Pro Lys  Trp Ala Val Cys Asn  Gly Val Asp Asp Cys  Arg Asp Asn 
    3695                 3700                 3705             


Ser Asp  Glu Gln Gly Cys Glu  Glu Arg Thr Cys His  Pro Val Gly 
    3710                 3715                 3720             


Asp Phe  Arg Cys Lys Asn His  His Cys Ile Pro Leu  Arg Trp Gln 
    3725                 3730                 3735             


Cys Asp  Gly Gln Asn Asp Cys  Gly Asp Asn Ser Asp  Glu Glu Asn 
    3740                 3745                 3750             


Cys Ala  Pro Arg Glu Cys Thr  Glu Ser Glu Phe Arg  Cys Val Asn 
    3755                 3760                 3765             


Gln Gln  Cys Ile Pro Ser Arg  Trp Ile Cys Asp His  Tyr Asn Asp 
    3770                 3775                 3780             


Cys Gly  Asp Asn Ser Asp Glu  Arg Asp Cys Glu Met  Arg Thr Cys 
    3785                 3790                 3795             


His Pro  Glu Tyr Phe Gln Cys  Thr Ser Gly His Cys  Val His Ser 
    3800                 3805                 3810             


Glu Leu  Lys Cys Asp Gly Ser  Ala Asp Cys Leu Asp  Ala Ser Asp 
    3815                 3820                 3825             


Glu Ala  Asp Cys Pro Thr Arg  Phe Pro Asp Gly Ala  Tyr Cys Gln 
    3830                 3835                 3840             


Ala Thr  Met Phe Glu Cys Lys  Asn His Val Cys Ile  Pro Pro Tyr 
    3845                 3850                 3855             


Trp Lys  Cys Asp Gly Asp Asp  Asp Cys Gly Asp Gly  Ser Asp Glu 
    3860                 3865                 3870             


Glu Leu  His Leu Cys Leu Asp  Val Pro Cys Asn Ser  Pro Asn Arg 
    3875                 3880                 3885             


Phe Arg  Cys Asp Asn Asn Arg  Cys Ile Tyr Ser His  Glu Val Cys 
    3890                 3895                 3900             


Asn Gly  Val Asp Asp Cys Gly  Asp Gly Thr Asp Glu  Thr Glu Glu 
    3905                 3910                 3915             


His Cys  Arg Lys Pro Thr Pro  Lys Pro Cys Thr Glu  Tyr Glu Tyr 
    3920                 3925                 3930             


Lys Cys  Gly Asn Gly His Cys  Ile Pro His Asp Asn  Val Cys Asp 
    3935                 3940                 3945             


Asp Ala  Asp Asp Cys Gly Asp  Trp Ser Asp Glu Leu  Gly Cys Asn 
    3950                 3955                 3960             


Lys Gly  Lys Glu Arg Thr Cys  Ala Glu Asn Ile Cys  Glu Gln Asn 
    3965                 3970                 3975             


Cys Thr  Gln Leu Asn Glu Gly  Gly Phe Ile Cys Ser  Cys Thr Ala 
    3980                 3985                 3990             


Gly Phe  Glu Thr Asn Val Phe  Asp Arg Thr Ser Cys  Leu Asp Ile 
    3995                 4000                 4005             


Asn Glu  Cys Glu Gln Phe Gly  Thr Cys Pro Gln His  Cys Arg Asn 
    4010                 4015                 4020             


Thr Lys  Gly Ser Tyr Glu Cys  Val Cys Ala Asp Gly  Phe Thr Ser 
    4025                 4030                 4035             


Met Ser  Asp Arg Pro Gly Lys  Arg Cys Ala Ala Glu  Gly Ser Ser 
    4040                 4045                 4050             


Pro Leu  Leu Leu Leu Pro Asp  Asn Val Arg Ile Arg  Lys Tyr Asn 
    4055                 4060                 4065             


Leu Ser  Ser Glu Arg Phe Ser  Glu Tyr Leu Gln Asp  Glu Glu Tyr 
    4070                 4075                 4080             


Ile Gln  Ala Val Asp Tyr Asp  Trp Asp Pro Lys Asp  Ile Gly Leu 
    4085                 4090                 4095             


Ser Val  Val Tyr Tyr Thr Val  Arg Gly Glu Gly Ser  Arg Phe Gly 
    4100                 4105                 4110             


Ala Ile  Lys Arg Ala Tyr Ile  Pro Asn Phe Glu Ser  Gly Arg Asn 
    4115                 4120                 4125             


Asn Leu  Val Gln Glu Val Asp  Leu Lys Leu Lys Tyr  Val Met Gln 
    4130                 4135                 4140             


Pro Asp  Gly Ile Ala Val Asp  Trp Val Gly Arg His  Ile Tyr Trp 
    4145                 4150                 4155             


Ser Asp  Val Lys Asn Lys Arg  Ile Glu Val Ala Lys  Leu Asp Gly 
    4160                 4165                 4170             


Arg Tyr  Arg Lys Trp Leu Ile  Ser Thr Asp Leu Asp  Gln Pro Ala 
    4175                 4180                 4185             


Ala Ile  Ala Val Asn Pro Lys  Leu Gly Leu Met Phe  Trp Thr Asp 
    4190                 4195                 4200             


Trp Gly  Lys Glu Pro Lys Ile  Glu Ser Ala Trp Met  Asn Gly Glu 
    4205                 4210                 4215             


Asp Arg  Asn Ile Leu Val Phe  Glu Asp Leu Gly Trp  Pro Thr Gly 
    4220                 4225                 4230             


Leu Ser  Ile Asp Tyr Leu Asn  Asn Asp Arg Ile Tyr  Trp Ser Asp 
    4235                 4240                 4245             


Phe Lys  Glu Asp Val Ile Glu  Thr Ile Lys Tyr Asp  Gly Thr Asp 
    4250                 4255                 4260             


Arg Arg  Val Ile Ala Lys Glu  Ala Met Asn Pro Tyr  Ser Leu Asp 
    4265                 4270                 4275             


Ile Phe  Glu Asp Gln Leu Tyr  Trp Ile Ser Lys Glu  Lys Gly Glu 
    4280                 4285                 4290             


Val Trp  Lys Gln Asn Lys Phe  Gly Gln Gly Lys Lys  Glu Lys Thr 
    4295                 4300                 4305             


Leu Val  Val Asn Pro Trp Leu  Thr Gln Val Arg Ile  Phe His Gln 
    4310                 4315                 4320             


Leu Arg  Tyr Asn Lys Ser Val  Pro Asn Leu Cys Lys  Gln Ile Cys 
    4325                 4330                 4335             


Ser His  Leu Cys Leu Leu Arg  Pro Gly Gly Tyr Ser  Cys Ala Cys 
    4340                 4345                 4350             


Pro Gln  Gly Ser Ser Phe Ile  Glu Gly Ser Thr Thr  Glu Cys Asp 
    4355                 4360                 4365             


Ala Ala  Ile Glu Leu Pro Ile  Asn Leu Pro Pro Pro  Cys Arg Cys 
    4370                 4375                 4380             


Met His  Gly Gly Asn Cys Tyr  Phe Asp Glu Thr Asp  Leu Pro Lys 
    4385                 4390                 4395             


Cys Lys  Cys Pro Ser Gly Tyr  Thr Gly Lys Tyr Cys  Glu Met Ala 
    4400                 4405                 4410             


Phe Ser  Lys Gly Ile Ser Pro  Gly Thr Thr Ala Val  Ala Val Leu 
    4415                 4420                 4425             


Leu Thr  Ile Leu Leu Ile Val  Val Ile Gly Ala Leu  Ala Ile Ala 
    4430                 4435                 4440             


Gly Phe  Phe His Tyr Arg Arg  Thr Gly Ser Leu Leu  Pro Ala Leu 
    4445                 4450                 4455             


Pro Lys  Leu Pro Ser Leu Ser  Ser Leu Val Lys Pro  Ser Glu Asn 
    4460                 4465                 4470             


Gly Asn  Gly Val Thr Phe Arg  Ser Gly Ala Asp Leu  Asn Met Asp 
    4475                 4480                 4485             


Ile Gly  Val Ser Gly Phe Gly  Pro Glu Thr Ala Ile  Asp Arg Ser 
    4490                 4495                 4500             


Met Ala  Met Ser Glu Asp Phe  Val Met Glu Met Gly  Lys Gln Pro 
    4505                 4510                 4515             


Ile Ile  Phe Glu Asn Pro Met  Tyr Ser Ala Arg Asp  Ser Ala Val 
    4520                 4525                 4530             


Lys Val  Val Gln Pro Ile Gln  Val Thr Val Ser Glu  Asn Val Asp 
    4535                 4540                 4545             


Asn Lys  Asn Tyr Gly Ser Pro  Ile Asn Pro Ser Glu  Ile Val Pro 
    4550                 4555                 4560             


Glu Thr  Asn Pro Thr Ser Pro  Ala Ala Asp Gly Thr  Gln Val Thr 
    4565                 4570                 4575             


Lys Trp  Asn Leu Phe Lys Arg  Lys Ser Lys Gln Thr  Thr Asn Phe 
    4580                 4585                 4590             


Glu Asn  Pro Ile Tyr Ala Gln  Met Glu Asn Glu Gln  Lys Glu Ser 
    4595                 4600                 4605             


Val Ala  Ala Thr Pro Pro Pro  Ser Pro Ser Leu Pro  Ala Lys Pro 
    4610                 4615                 4620             


Lys Pro  Pro Ser Arg Arg Asp  Pro Thr Pro Thr Tyr  Ser Ala Thr 
    4625                 4630                 4635             


Glu Asp  Thr Phe Lys Asp Thr  Ala Asn Leu Val Lys  Glu Asp Ser 
    4640                 4645                 4650             


Glu Val  
    4655 


<210>  2
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Asp Ser Ala His Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala 
1               5                   10                  15      


Asp Trp Arg Cys Asp Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu 
            20                  25                  30          


Ile Gly Cys Ala Val Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln 
        35                  40                  45              


Ser Glu Gly Gln Cys Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln 
    50                  55                  60                  


Asp Cys Asp Asp Gly Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr 
65                  70                  75                  80  


Cys Ser Ser His Gln Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser 
                85                  90                  95      


Glu Tyr Arg Cys Asp His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu 
            100                 105                 110         


Asn Asp Cys Gln Tyr Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly 
        115                 120                 125             


Ala Cys Tyr Asn Thr Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg 
    130                 135                 140                 


Asp Ser Ser Asp Glu Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu 
145                 150                 155                 160 


Phe Ser Cys Gly Asn Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp 
                165                 170                 175     


His Asp Asn Asp Cys Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr 
            180                 185                 190         


Pro Thr Cys Gly Gly Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile 
        195                 200                 205             


Tyr Gln Asn Trp Val Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly 
    210                 215                 220                 


Asp Glu Asp Gly Cys Glu Ser Gly Pro His Asp Val His Lys Cys Ser 
225                 230                 235                 240 


Pro Arg Glu Trp Ser Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr 
                245                 250                 255     


Lys Val Cys Asp Gly Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn 
            260                 265                 270         


Asn Thr Ser Thr Gly Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu 
        275                 280                 285             


Asn Cys Gln Tyr Gln Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe 
    290                 295                 300                 


Cys Pro Pro Gly Tyr Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val 
305                 310                 315                 320 


Glu Phe Asp Asp Cys Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu 
                325                 330                 335     


Ser Arg Pro Gly Arg His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu 
            340                 345                 350         


Glu Arg Gly Gln Tyr Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser 
        355                 360                 365             


Ile Ile Phe Ser Asn Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly 
    370                 375                 380                 


Arg Ser Phe Arg Ile Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val 
385                 390                 395                 400 


Gly Val Ala Phe His Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr 
                405                 410                 415     


Val Gln Asn Lys Val Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln 
            420                 425                 430         


Glu Val Leu Asn Val Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp 
        435                 440                 445             


Trp Val Asn Asn Lys Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile 
    450                 455                 460                 


Asp Met Val Asn Leu Asp Gly Ser Tyr Arg 
465                 470                 


<210>  3
<211>  1493
<212>  PRT
<213>  Homo sapiens

<400>  3

Val Leu Asn Val Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp 
1               5                   10                  15      


Val Asn Asn Lys Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp 
            20                  25                  30          


Met Val Asn Leu Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn 
        35                  40                  45              


Leu Gly His Pro Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu 
    50                  55                  60                  


Phe Phe Ser Asp Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg 
65                  70                  75                  80  


Ala Phe Met Asp Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu 
                85                  90                  95      


Gly Trp Pro Ala Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr 
            100                 105                 110         


Trp Val Asp Ser Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly 
        115                 120                 125             


Ile Gln Arg Lys Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro 
    130                 135                 140                 


Phe Gly Val Ser Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr 
145                 150                 155                 160 


Lys Met Ala Val Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln 
                165                 170                 175     


Val Tyr Tyr Gln Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His 
            180                 185                 190         


Ser Leu Arg Gln Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly 
        195                 200                 205             


Gly Cys Glu Gln Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly 
    210                 215                 220                 


Leu Gly Phe Arg Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp 
225                 230                 235                 240 


Glu Arg His Cys Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln 
                245                 250                 255     


Val Ala Ile Arg Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val 
            260                 265                 270         


Met Val Pro Val Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe 
        275                 280                 285             


Asp Ala Gln Asp Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met 
    290                 295                 300                 


Ile Phe Lys Gln Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala 
305                 310                 315                 320 


Asn Arg Val Glu Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys 
                325                 330                 335     


Asn Leu Tyr Trp Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg 
            340                 345                 350         


Leu Ala Asp Lys Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro 
        355                 360                 365             


Arg Ser Val Val Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp 
    370                 375                 380                 


Trp Phe Arg Pro Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His 
385                 390                 395                 400 


Leu Leu Pro Val Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala 
                405                 410                 415     


Ile Asp Trp Ala Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp 
            420                 425                 430         


Lys Ile Glu His Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu Gly 
        435                 440                 445             


His Ile Glu Gln Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly Glu 
    450                 455                 460                 


His Leu Phe Phe Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val Arg 
465                 470                 475                 480 


Lys Ala Asp Gly Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala Tyr 
                485                 490                 495     


Ile Leu His Leu Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser Asn 
            500                 505                 510         


Ala Cys Asn Gln Pro Thr His Pro Asn Gly Asp Cys Ser His Phe Cys 
        515                 520                 525             


Phe Pro Val Pro Asn Phe Gln Arg Val Cys Gly Cys Pro Tyr Gly Met 
    530                 535                 540                 


Arg Leu Ala Ser Asn His Leu Thr Cys Glu Gly Asp Pro Thr Asn Glu 
545                 550                 555                 560 


Pro Pro Thr Glu Gln Cys Gly Leu Phe Ser Phe Pro Cys Lys Asn Gly 
                565                 570                 575     


Arg Cys Val Pro Asn Tyr Tyr Leu Cys Asp Gly Val Asp Asp Cys His 
            580                 585                 590         


Asp Asn Ser Asp Glu Gln Leu Cys Gly Thr Leu Asn Asn Thr Cys Ser 
        595                 600                 605             


Ser Ser Ala Phe Thr Cys Gly His Gly Glu Cys Ile Pro Ala His Trp 
    610                 615                 620                 


Arg Cys Asp Lys Arg Asn Asp Cys Val Asp Gly Ser Asp Glu His Asn 
625                 630                 635                 640 


Cys Pro Thr His Ala Pro Ala Ser Cys Leu Asp Thr Gln Tyr Thr Cys 
                645                 650                 655     


Asp Asn His Gln Cys Ile Ser Lys Asn Trp Val Cys Asp Thr Asp Asn 
            660                 665                 670         


Asp Cys Gly Asp Gly Ser Asp Glu Lys Asn Cys Asn Ser Thr Glu Thr 
        675                 680                 685             


Cys Gln Pro Ser Gln Phe Asn Cys Pro Asn His Arg Cys Ile Asp Leu 
    690                 695                 700                 


Ser Phe Val Cys Asp Gly Asp Lys Asp Cys Val Asp Gly Ser Asp Glu 
705                 710                 715                 720 


Val Gly Cys Val Leu Asn Cys Thr Ala Ser Gln Phe Lys Cys Ala Ser 
                725                 730                 735     


Gly Asp Lys Cys Ile Gly Val Thr Asn Arg Cys Asp Gly Val Phe Asp 
            740                 745                 750         


Cys Ser Asp Asn Ser Asp Glu Ala Gly Cys Pro Thr Arg Pro Pro Gly 
        755                 760                 765             


Met Cys His Ser Asp Glu Phe Gln Cys Gln Glu Asp Gly Ile Cys Ile 
    770                 775                 780                 


Pro Asn Phe Trp Glu Cys Asp Gly His Pro Asp Cys Leu Tyr Gly Ser 
785                 790                 795                 800 


Asp Glu His Asn Ala Cys Val Pro Lys Thr Cys Pro Ser Ser Tyr Phe 
                805                 810                 815     


His Cys Asp Asn Gly Asn Cys Ile His Arg Ala Trp Leu Cys Asp Arg 
            820                 825                 830         


Asp Asn Asp Cys Gly Asp Met Ser Asp Glu Lys Asp Cys Pro Thr Gln 
        835                 840                 845             


Pro Phe Arg Cys Pro Ser Trp Gln Trp Gln Cys Leu Gly His Asn Ile 
    850                 855                 860                 


Cys Val Asn Leu Ser Val Val Cys Asp Gly Ile Phe Asp Cys Pro Asn 
865                 870                 875                 880 


Gly Thr Asp Glu Ser Pro Leu Cys Asn Gly Asn Ser Cys Ser Asp Phe 
                885                 890                 895     


Asn Gly Gly Cys Thr His Glu Cys Val Gln Glu Pro Phe Gly Ala Lys 
            900                 905                 910         


Cys Leu Cys Pro Leu Gly Phe Leu Leu Ala Asn Asp Ser Lys Thr Cys 
        915                 920                 925             


Glu Asp Ile Asp Glu Cys Asp Ile Leu Gly Ser Cys Ser Gln His Cys 
    930                 935                 940                 


Tyr Asn Met Arg Gly Ser Phe Arg Cys Ser Cys Asp Thr Gly Tyr Met 
945                 950                 955                 960 


Leu Glu Ser Asp Gly Arg Thr Cys Lys Val Thr Ala Ser Glu Ser Leu 
                965                 970                 975     


Leu Leu Leu Val Ala Ser Gln Asn Lys Ile Ile Ala Asp Ser Val Thr 
            980                 985                 990         


Ser Gln Val His Asn Ile Tyr Ser  Leu Val Glu Asn Gly  Ser Tyr Ile 
        995                 1000                 1005             


Val Ala  Val Asp Phe Asp Ser  Ile Ser Gly Arg Ile  Phe Trp Ser 
    1010                 1015                 1020             


Asp Ala  Thr Gln Gly Lys Thr  Trp Ser Ala Phe Gln  Asn Gly Thr 
    1025                 1030                 1035             


Asp Arg  Arg Val Val Phe Asp  Ser Ser Ile Ile Leu  Thr Glu Thr 
    1040                 1045                 1050             


Ile Ala  Ile Asp Trp Val Gly  Arg Asn Leu Tyr Trp  Thr Asp Tyr 
    1055                 1060                 1065             


Ala Leu  Glu Thr Ile Glu Val  Ser Lys Ile Asp Gly  Ser His Arg 
    1070                 1075                 1080             


Thr Val  Leu Ile Ser Lys Asn  Leu Thr Asn Pro Arg  Gly Leu Ala 
    1085                 1090                 1095             


Leu Asp  Pro Arg Met Asn Glu  His Leu Leu Phe Trp  Ser Asp Trp 
    1100                 1105                 1110             


Gly His  His Pro Arg Ile Glu  Arg Ala Ser Met Asp  Gly Ser Met 
    1115                 1120                 1125             


Arg Thr  Val Ile Val Gln Asp  Lys Ile Phe Trp Pro  Cys Gly Leu 
    1130                 1135                 1140             


Thr Ile  Asp Tyr Pro Asn Arg  Leu Leu Tyr Phe Met  Asp Ser Tyr 
    1145                 1150                 1155             


Leu Asp  Tyr Met Asp Phe Cys  Asp Tyr Asn Gly His  His Arg Arg 
    1160                 1165                 1170             


Gln Val  Ile Ala Ser Asp Leu  Ile Ile Arg His Pro  Tyr Ala Leu 
    1175                 1180                 1185             


Thr Leu  Phe Glu Asp Ser Val  Tyr Trp Thr Asp Arg  Ala Thr Arg 
    1190                 1195                 1200             


Arg Val  Met Arg Ala Asn Lys  Trp His Gly Gly Asn  Gln Ser Val 
    1205                 1210                 1215             


Val Met  Tyr Asn Ile Gln Trp  Pro Leu Gly Ile Val  Ala Val His 
    1220                 1225                 1230             


Pro Ser  Lys Gln Pro Asn Ser  Val Asn Pro Cys Ala  Phe Ser Arg 
    1235                 1240                 1245             


Cys Ser  His Leu Cys Leu Leu  Ser Ser Gln Gly Pro  His Phe Tyr 
    1250                 1255                 1260             


Ser Cys  Val Cys Pro Ser Gly  Trp Ser Leu Ser Pro  Asp Leu Leu 
    1265                 1270                 1275             


Asn Cys  Leu Arg Asp Asp Gln  Pro Phe Leu Ile Thr  Val Arg Gln 
    1280                 1285                 1290             


His Ile  Ile Phe Gly Ile Ser  Leu Asn Pro Glu Val  Lys Ser Asn 
    1295                 1300                 1305             


Asp Ala  Met Val Pro Ile Ala  Gly Ile Gln Asn Gly  Leu Asp Val 
    1310                 1315                 1320             


Glu Phe  Asp Asp Ala Glu Gln  Tyr Ile Tyr Trp Val  Glu Asn Pro 
    1325                 1330                 1335             


Gly Glu  Ile His Arg Val Lys  Thr Asp Gly Thr Asn  Arg Thr Val 
    1340                 1345                 1350             


Phe Ala  Ser Ile Ser Met Val  Gly Pro Ser Met Asn  Leu Ala Leu 
    1355                 1360                 1365             


Asp Trp  Ile Ser Arg Asn Leu  Tyr Ser Thr Asn Pro  Arg Thr Gln 
    1370                 1375                 1380             


Ser Ile  Glu Val Leu Thr Leu  His Gly Asp Ile Arg  Tyr Arg Lys 
    1385                 1390                 1395             


Thr Leu  Ile Ala Asn Asp Gly  Thr Ala Leu Gly Val  Gly Phe Pro 
    1400                 1405                 1410             


Ile Gly  Ile Thr Val Asp Pro  Ala Arg Gly Lys Leu  Tyr Trp Ser 
    1415                 1420                 1425             


Asp Gln  Gly Thr Asp Ser Gly  Val Pro Ala Lys Ile  Ala Ser Ala 
    1430                 1435                 1440             


Asn Met  Asp Gly Thr Ser Val  Lys Thr Leu Phe Thr  Gly Asn Leu 
    1445                 1450                 1455             


Glu His  Leu Glu Cys Val Thr  Leu Asp Ile Glu Glu  Gln Lys Leu 
    1460                 1465                 1470             


Tyr Trp  Ala Val Thr Gly Arg  Gly Val Ile Glu Arg  Gly Asn Val 
    1475                 1480                 1485             


Asp Gly  Thr Asp Arg 
    1490             


<210>  4
<211>  855
<212>  PRT
<213>  Homo sapiens

<400>  4

Ile Val Asn Ser Ser Leu Val Met Pro Ser Gly Leu Thr Leu Asp Tyr 
1               5                   10                  15      


Glu Glu Asp Leu Leu Tyr Trp Val Asp Ala Ser Leu Gln Arg Ile Glu 
            20                  25                  30          


Arg Ser Thr Leu Thr Gly Val Asp Arg Glu Val Ile Val Asn Ala Ala 
        35                  40                  45              


Val His Ala Phe Gly Leu Thr Leu Tyr Gly Gln Tyr Ile Tyr Trp Thr 
    50                  55                  60                  


Asp Leu Tyr Thr Gln Arg Ile Tyr Arg Ala Asn Lys Tyr Asp Gly Ser 
65                  70                  75                  80  


Gly Gln Ile Ala Met Thr Thr Asn Leu Leu Ser Gln Pro Arg Gly Ile 
                85                  90                  95      


Asn Thr Val Val Lys Asn Gln Lys Gln Gln Cys Asn Asn Pro Cys Glu 
            100                 105                 110         


Gln Phe Asn Gly Gly Cys Ser His Ile Cys Ala Pro Gly Pro Asn Gly 
        115                 120                 125             


Ala Glu Cys Gln Cys Pro His Glu Gly Asn Trp Tyr Leu Ala Asn Asn 
    130                 135                 140                 


Arg Lys His Cys Ile Val Asp Asn Gly Glu Arg Cys Gly Ala Ser Ser 
145                 150                 155                 160 


Phe Thr Cys Ser Asn Gly Arg Cys Ile Ser Glu Glu Trp Lys Cys Asp 
                165                 170                 175     


Asn Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Met Glu Ser Val Cys 
            180                 185                 190         


Ala Leu His Thr Cys Ser Pro Thr Ala Phe Thr Cys Ala Asn Gly Arg 
        195                 200                 205             


Cys Val Gln Tyr Ser Tyr Arg Cys Asp Tyr Tyr Asn Asp Cys Gly Asp 
    210                 215                 220                 


Gly Ser Asp Glu Ala Gly Cys Leu Phe Arg Asp Cys Asn Ala Thr Thr 
225                 230                 235                 240 


Glu Phe Met Cys Asn Asn Arg Arg Cys Ile Pro Arg Glu Phe Ile Cys 
                245                 250                 255     


Asn Gly Val Asp Asn Cys His Asp Asn Asn Thr Ser Asp Glu Lys Asn 
            260                 265                 270         


Cys Pro Asp Arg Thr Cys Gln Ser Gly Tyr Thr Lys Cys His Asn Ser 
        275                 280                 285             


Asn Ile Cys Ile Pro Arg Val Tyr Leu Cys Asp Gly Asp Asn Asp Cys 
    290                 295                 300                 


Gly Asp Asn Ser Asp Glu Asn Pro Thr Tyr Cys Thr Thr His Thr Cys 
305                 310                 315                 320 


Ser Ser Ser Glu Phe Gln Cys Ala Ser Gly Arg Cys Ile Pro Gln His 
                325                 330                 335     


Trp Tyr Cys Asp Gln Glu Thr Asp Cys Phe Asp Ala Ser Asp Glu Pro 
            340                 345                 350         


Ala Ser Cys Gly His Ser Glu Arg Thr Cys Leu Ala Asp Glu Phe Lys 
        355                 360                 365             


Cys Asp Gly Gly Arg Cys Ile Pro Ser Glu Trp Ile Cys Asp Gly Asp 
    370                 375                 380                 


Asn Asp Cys Gly Asp Met Ser Asp Glu Asp Lys Arg His Gln Cys Gln 
385                 390                 395                 400 


Asn Gln Asn Cys Ser Asp Ser Glu Phe Leu Cys Val Asn Asp Arg Pro 
                405                 410                 415     


Pro Asp Arg Arg Cys Ile Pro Gln Ser Trp Val Cys Asp Gly Asp Val 
            420                 425                 430         


Asp Cys Thr Asp Gly Tyr Asp Glu Asn Gln Asn Cys Thr Arg Arg Thr 
        435                 440                 445             


Cys Ser Glu Asn Glu Phe Thr Cys Gly Tyr Gly Leu Cys Ile Pro Lys 
    450                 455                 460                 


Ile Phe Arg Cys Asp Arg His Asn Asp Cys Gly Asp Tyr Ser Asp Glu 
465                 470                 475                 480 


Arg Gly Cys Leu Tyr Gln Thr Cys Gln Gln Asn Gln Phe Thr Cys Gln 
                485                 490                 495     


Asn Gly Arg Cys Ile Ser Lys Thr Phe Val Cys Asp Glu Asp Asn Asp 
            500                 505                 510         


Cys Gly Asp Gly Ser Asp Glu Leu Met His Leu Cys His Thr Pro Glu 
        515                 520                 525             


Pro Thr Cys Pro Pro His Glu Phe Lys Cys Asp Asn Gly Arg Cys Ile 
    530                 535                 540                 


Glu Met Met Lys Leu Cys Asn His Leu Asp Asp Cys Leu Asp Asn Ser 
545                 550                 555                 560 


Asp Glu Lys Gly Cys Gly Ile Asn Glu Cys His Asp Pro Ser Ile Ser 
                565                 570                 575     


Gly Cys Asp His Asn Cys Thr Asp Thr Leu Thr Ser Phe Tyr Cys Ser 
            580                 585                 590         


Cys Arg Pro Gly Tyr Lys Leu Met Ser Asp Lys Arg Thr Cys Val Asp 
        595                 600                 605             


Ile Asp Glu Cys Thr Glu Met Pro Phe Val Cys Ser Gln Lys Cys Glu 
    610                 615                 620                 


Asn Val Ile Gly Ser Tyr Ile Cys Lys Cys Ala Pro Gly Tyr Leu Arg 
625                 630                 635                 640 


Glu Pro Asp Gly Lys Thr Cys Arg Gln Asn Ser Asn Ile Glu Pro Tyr 
                645                 650                 655     


Leu Ile Phe Ser Asn Arg Tyr Tyr Leu Arg Asn Leu Thr Ile Asp Gly 
            660                 665                 670         


Tyr Phe Tyr Ser Leu Ile Leu Glu Gly Leu Asp Asn Val Val Ala Leu 
        675                 680                 685             


Asp Phe Asp Arg Val Glu Lys Arg Leu Tyr Trp Ile Asp Thr Gln Arg 
    690                 695                 700                 


Gln Val Ile Glu Arg Met Phe Leu Asn Lys Thr Asn Lys Glu Thr Ile 
705                 710                 715                 720 


Ile Asn His Arg Leu Pro Ala Ala Glu Ser Leu Ala Val Asp Trp Val 
                725                 730                 735     


Ser Arg Lys Leu Tyr Trp Leu Asp Ala Arg Leu Asp Gly Leu Phe Val 
            740                 745                 750         


Ser Asp Leu Asn Gly Gly His Arg Arg Met Leu Ala Gln His Cys Val 
        755                 760                 765             


Asp Ala Asn Asn Thr Phe Cys Phe Asp Asn Pro Arg Gly Leu Ala Leu 
    770                 775                 780                 


His Pro Gln Tyr Gly Tyr Leu Tyr Trp Ala Asp Trp Gly His Arg Ala 
785                 790                 795                 800 


Tyr Ile Gly Arg Val Gly Met Asp Gly Thr Asn Lys Ser Val Ile Ile 
                805                 810                 815     


Ser Thr Lys Leu Glu Trp Pro Asn Gly Ile Thr Ile Asp Tyr Thr Asn 
            820                 825                 830         


Asp Leu Leu Tyr Trp Ala Asp Ala His Leu Gly Tyr Ile Glu Tyr Ser 
        835                 840                 845             


Asp Leu Glu Gly His His Arg 
    850                 855 


<210>  5
<211>  1248
<212>  PRT
<213>  Homo sapiens

<400>  5

Pro His Pro Phe Ala Ile Thr Ile Phe Glu Asp Thr Ile Tyr Trp Thr 
1               5                   10                  15      


Asp Trp Asn Thr Arg Thr Val Glu Lys Gly Asn Lys Tyr Asp Gly Ser 
            20                  25                  30          


Asn Arg Gln Thr Leu Val Asn Thr Thr His Arg Pro Phe Asp Ile His 
        35                  40                  45              


Val Tyr His Pro Tyr Arg Gln Pro Ile Val Ser Asn Pro Cys Gly Thr 
    50                  55                  60                  


Asn Asn Gly Gly Cys Ser His Leu Cys Leu Ile Lys Pro Gly Gly Lys 
65                  70                  75                  80  


Gly Phe Thr Cys Glu Cys Pro Asp Asp Phe Arg Thr Leu Gln Leu Ser 
                85                  90                  95      


Gly Ser Thr Tyr Cys Met Pro Met Cys Ser Ser Thr Gln Phe Leu Cys 
            100                 105                 110         


Ala Asn Asn Glu Lys Cys Ile Pro Ile Trp Trp Lys Cys Asp Gly Gln 
        115                 120                 125             


Lys Asp Cys Ser Asp Gly Ser Asp Glu Leu Ala Leu Cys Pro Gln Arg 
    130                 135                 140                 


Phe Cys Arg Leu Gly Gln Phe Gln Cys Ser Asp Gly Asn Cys Thr Ser 
145                 150                 155                 160 


Pro Gln Thr Leu Cys Asn Ala His Gln Asn Cys Pro Asp Gly Ser Asp 
                165                 170                 175     


Glu Asp Arg Leu Leu Cys Glu Asn His His Cys Asp Ser Asn Glu Trp 
            180                 185                 190         


Gln Cys Ala Asn Lys Arg Cys Ile Pro Glu Ser Trp Gln Cys Asp Thr 
        195                 200                 205             


Phe Asn Asp Cys Glu Asp Asn Ser Asp Glu Asp Ser Ser His Cys Ala 
    210                 215                 220                 


Ser Arg Thr Cys Arg Pro Gly Gln Phe Arg Cys Ala Asn Gly Arg Cys 
225                 230                 235                 240 


Ile Pro Gln Ala Trp Lys Cys Asp Val Asp Asn Asp Cys Gly Asp His 
                245                 250                 255     


Ser Asp Glu Pro Ile Glu Glu Cys Met Ser Ser Ala His Leu Cys Asp 
            260                 265                 270         


Asn Phe Thr Glu Phe Ser Cys Lys Thr Asn Tyr Arg Cys Ile Pro Lys 
        275                 280                 285             


Trp Ala Val Cys Asn Gly Val Asp Asp Cys Arg Asp Asn Ser Asp Glu 
    290                 295                 300                 


Gln Gly Cys Glu Glu Arg Thr Cys His Pro Val Gly Asp Phe Arg Cys 
305                 310                 315                 320 


Lys Asn His His Cys Ile Pro Leu Arg Trp Gln Cys Asp Gly Gln Asn 
                325                 330                 335     


Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Ala Pro Arg Glu Cys 
            340                 345                 350         


Thr Glu Ser Glu Phe Arg Cys Val Asn Gln Gln Cys Ile Pro Ser Arg 
        355                 360                 365             


Trp Ile Cys Asp His Tyr Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg 
    370                 375                 380                 


Asp Cys Glu Met Arg Thr Cys His Pro Glu Tyr Phe Gln Cys Thr Ser 
385                 390                 395                 400 


Gly His Cys Val His Ser Glu Leu Lys Cys Asp Gly Ser Ala Asp Cys 
                405                 410                 415     


Leu Asp Ala Ser Asp Glu Ala Asp Cys Pro Thr Arg Phe Pro Asp Gly 
            420                 425                 430         


Ala Tyr Cys Gln Ala Thr Met Phe Glu Cys Lys Asn His Val Cys Ile 
        435                 440                 445             


Pro Pro Tyr Trp Lys Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser 
    450                 455                 460                 


Asp Glu Glu Leu His Leu Cys Leu Asp Val Pro Cys Asn Ser Pro Asn 
465                 470                 475                 480 


Arg Phe Arg Cys Asp Asn Asn Arg Cys Ile Tyr Ser His Glu Val Cys 
                485                 490                 495     


Asn Gly Val Asp Asp Cys Gly Asp Gly Thr Asp Glu Thr Glu Glu His 
            500                 505                 510         


Cys Arg Lys Pro Thr Pro Lys Pro Cys Thr Glu Tyr Glu Tyr Lys Cys 
        515                 520                 525             


Gly Asn Gly His Cys Ile Pro His Asp Asn Val Cys Asp Asp Ala Asp 
    530                 535                 540                 


Asp Cys Gly Asp Trp Ser Asp Glu Leu Gly Cys Asn Lys Gly Lys Glu 
545                 550                 555                 560 


Arg Thr Cys Ala Glu Asn Ile Cys Glu Gln Asn Cys Thr Gln Leu Asn 
                565                 570                 575     


Glu Gly Gly Phe Ile Cys Ser Cys Thr Ala Gly Phe Glu Thr Asn Val 
            580                 585                 590         


Phe Asp Arg Thr Ser Cys Leu Asp Ile Asn Glu Cys Glu Gln Phe Gly 
        595                 600                 605             


Thr Cys Pro Gln His Cys Arg Asn Thr Lys Gly Ser Tyr Glu Cys Val 
    610                 615                 620                 


Cys Ala Asp Gly Phe Thr Ser Met Ser Asp Arg Pro Gly Lys Arg Cys 
625                 630                 635                 640 


Ala Ala Glu Gly Ser Ser Pro Leu Leu Leu Leu Pro Asp Asn Val Arg 
                645                 650                 655     


Ile Arg Lys Tyr Asn Leu Ser Ser Glu Arg Phe Ser Glu Tyr Leu Gln 
            660                 665                 670         


Asp Glu Glu Tyr Ile Gln Ala Val Asp Tyr Asp Trp Asp Pro Lys Asp 
        675                 680                 685             


Ile Gly Leu Ser Val Val Tyr Tyr Thr Val Arg Gly Glu Gly Ser Arg 
    690                 695                 700                 


Phe Gly Ala Ile Lys Arg Ala Tyr Ile Pro Asn Phe Glu Ser Gly Arg 
705                 710                 715                 720 


Asn Asn Leu Val Gln Glu Val Asp Leu Lys Leu Lys Tyr Val Met Gln 
                725                 730                 735     


Pro Asp Gly Ile Ala Val Asp Trp Val Gly Arg His Ile Tyr Trp Ser 
            740                 745                 750         


Asp Val Lys Asn Lys Arg Ile Glu Val Ala Lys Leu Asp Gly Arg Tyr 
        755                 760                 765             


Arg Lys Trp Leu Ile Ser Thr Asp Leu Asp Gln Pro Ala Ala Ile Ala 
    770                 775                 780                 


Val Asn Pro Lys Leu Gly Leu Met Phe Trp Thr Asp Trp Gly Lys Glu 
785                 790                 795                 800 


Pro Lys Ile Glu Ser Ala Trp Met Asn Gly Glu Asp Arg Asn Ile Leu 
                805                 810                 815     


Val Phe Glu Asp Leu Gly Trp Pro Thr Gly Leu Ser Ile Asp Tyr Leu 
            820                 825                 830         


Asn Asn Asp Arg Ile Tyr Trp Ser Asp Phe Lys Glu Asp Val Ile Glu 
        835                 840                 845             


Thr Ile Lys Tyr Asp Gly Thr Asp Arg Arg Val Ile Ala Lys Glu Ala 
    850                 855                 860                 


Met Asn Pro Tyr Ser Leu Asp Ile Phe Glu Asp Gln Leu Tyr Trp Ile 
865                 870                 875                 880 


Ser Lys Glu Lys Gly Glu Val Trp Lys Gln Asn Lys Phe Gly Gln Gly 
                885                 890                 895     


Lys Lys Glu Lys Thr Leu Val Val Asn Pro Trp Leu Thr Gln Val Arg 
            900                 905                 910         


Ile Phe His Gln Leu Arg Tyr Asn Lys Ser Val Pro Asn Leu Cys Lys 
        915                 920                 925             


Gln Ile Cys Ser His Leu Cys Leu Leu Arg Pro Gly Gly Tyr Ser Cys 
    930                 935                 940                 


Ala Cys Pro Gln Gly Ser Ser Phe Ile Glu Gly Ser Thr Thr Glu Cys 
945                 950                 955                 960 


Asp Ala Ala Ile Glu Leu Pro Ile Asn Leu Pro Pro Pro Cys Arg Cys 
                965                 970                 975     


Met His Gly Gly Asn Cys Tyr Phe Asp Glu Thr Asp Leu Pro Lys Cys 
            980                 985                 990         


Lys Cys Pro Ser Gly Tyr Thr Gly  Lys Tyr Cys Glu Met  Ala Phe Ser 
        995                 1000                 1005             


Lys Gly  Ile Ser Pro Gly Thr  Thr Ala Val Ala Val  Leu Leu Thr 
    1010                 1015                 1020             


Ile Leu  Leu Ile Val Val Ile  Gly Ala Leu Ala Ile  Ala Gly Phe 
    1025                 1030                 1035             


Phe His  Tyr Arg Arg Thr Gly  Ser Leu Leu Pro Ala  Leu Pro Lys 
    1040                 1045                 1050             


Leu Pro  Ser Leu Ser Ser Leu  Val Lys Pro Ser Glu  Asn Gly Asn 
    1055                 1060                 1065             


Gly Val  Thr Phe Arg Ser Gly  Ala Asp Leu Asn Met  Asp Ile Gly 
    1070                 1075                 1080             


Val Ser  Gly Phe Gly Pro Glu  Thr Ala Ile Asp Arg  Ser Met Ala 
    1085                 1090                 1095             


Met Ser  Glu Asp Phe Val Met  Glu Met Gly Lys Gln  Pro Ile Ile 
    1100                 1105                 1110             


Phe Glu  Asn Pro Met Tyr Ser  Ala Arg Asp Ser Ala  Val Lys Val 
    1115                 1120                 1125             


Val Gln  Pro Ile Gln Val Thr  Val Ser Glu Asn Val  Asp Asn Lys 
    1130                 1135                 1140             


Asn Tyr  Gly Ser Pro Ile Asn  Pro Ser Glu Ile Val  Pro Glu Thr 
    1145                 1150                 1155             


Asn Pro  Thr Ser Pro Ala Ala  Asp Gly Thr Gln Val  Thr Lys Trp 
    1160                 1165                 1170             


Asn Leu  Phe Lys Arg Lys Ser  Lys Gln Thr Thr Asn  Phe Glu Asn 
    1175                 1180                 1185             


Pro Ile  Tyr Ala Gln Met Glu  Asn Glu Gln Lys Glu  Ser Val Ala 
    1190                 1195                 1200             


Ala Thr  Pro Pro Pro Ser Pro  Ser Leu Pro Ala Lys  Pro Lys Pro 
    1205                 1210                 1215             


Pro Ser  Arg Arg Asp Pro Thr  Pro Thr Tyr Ser Ala  Thr Glu Asp 
    1220                 1225                 1230             


Thr Phe  Lys Asp Thr Ala Asn  Leu Val Lys Glu Asp  Ser Glu Val 
    1235                 1240                 1245             


<210>  6
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Asp Ser Ala His Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala 
1               5                   10                  15      


Asp Trp Arg Cys Asp Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu 
            20                  25                  30          


<210>  7
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  7

Cys Ser Ser His Gln Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser 
1               5                   10                  15      


Glu Tyr Arg Cys Asp His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu 
            20                  25                  30          


Asn Asp Cys Gln Tyr Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly 
        35                  40                  45              


Ala Cys Tyr Asn Thr Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg 
    50                  55                  60                  


Asp Ser Ser Asp Glu Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu 
65                  70                  75                  80  


Phe Ser Cys Gly Asn Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp 
                85                  90                  95      


His Asp Asn Asp Cys Gln Asp Gly Ser Asp Glu 
            100                 105         


<210>  8
<211>  683
<212>  PRT
<213>  Homo sapiens

<400>  8

Cys Gly Gly Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile Tyr Gln 
1               5                   10                  15      


Asn Trp Val Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly Asp Glu 
            20                  25                  30          


Asp Gly Cys Glu Ser Gly Pro His Asp Val His Lys Cys Ser Pro Arg 
        35                  40                  45              


Glu Trp Ser Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr Lys Val 
    50                  55                  60                  


Cys Asp Gly Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn Asn Thr 
65                  70                  75                  80  


Ser Thr Gly Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu Asn Cys 
                85                  90                  95      


Gln Tyr Gln Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe Cys Pro 
            100                 105                 110         


Pro Gly Tyr Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val Glu Phe 
        115                 120                 125             


Asp Asp Cys Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu Ser Arg 
    130                 135                 140                 


Pro Gly Arg His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu Glu Arg 
145                 150                 155                 160 


Gly Gln Tyr Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser Ile Ile 
                165                 170                 175     


Phe Ser Asn Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly Arg Ser 
            180                 185                 190         


Phe Arg Ile Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val Gly Val 
        195                 200                 205             


Ala Phe His Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr Val Gln 
    210                 215                 220                 


Asn Lys Val Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln Glu Val 
225                 230                 235                 240 


Leu Asn Val Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp Trp Val 
                245                 250                 255     


Asn Asn Lys Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile Asp Met 
            260                 265                 270         


Val Asn Leu Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu Asn Leu 
        275                 280                 285             


Gly His Pro Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr Leu Phe 
    290                 295                 300                 


Phe Ser Asp Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu Arg Ala 
305                 310                 315                 320 


Phe Met Asp Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys Leu Gly 
                325                 330                 335     


Trp Pro Ala Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val Tyr Trp 
            340                 345                 350         


Val Asp Ser Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp Gly Ile 
        355                 360                 365             


Gln Arg Lys Thr Val Val His Gly Gly Ser Leu Ile Pro His Pro Phe 
    370                 375                 380                 


Gly Val Ser Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp Thr Lys 
385                 390                 395                 400 


Met Ala Val Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro Gln Val 
                405                 410                 415     


Tyr Tyr Gln Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr His Ser 
            420                 425                 430         


Leu Arg Gln Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn Gly Gly 
        435                 440                 445             


Cys Glu Gln Val Cys Val Leu Ser His Arg Thr Asp Asn Asp Gly Leu 
    450                 455                 460                 


Gly Phe Arg Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr Asp Glu 
465                 470                 475                 480 


Arg His Cys Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser Gln Val 
                485                 490                 495     


Ala Ile Arg Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp Val Met 
            500                 505                 510         


Val Pro Val Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp Phe Asp 
        515                 520                 525             


Ala Gln Asp Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His Met Ile 
    530                 535                 540                 


Phe Lys Gln Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala Ala Asn 
545                 550                 555                 560 


Arg Val Glu Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser Lys Asn 
                565                 570                 575     


Leu Tyr Trp Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met Arg Leu 
            580                 585                 590         


Ala Asp Lys Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn Pro Arg 
        595                 600                 605             


Ser Val Val Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr Asp Trp 
    610                 615                 620                 


Phe Arg Pro Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser His Leu 
625                 630                 635                 640 


Leu Pro Val Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu Ala Ile 
                645                 650                 655     


Asp Trp Ala Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe Asp Lys 
            660                 665                 670         


Ile Glu His Ser Thr Phe Asp Gly Leu Asp Arg 
        675                 680             


<210>  9
<211>  1518
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Cys Gly Leu Phe Ser Phe Pro Cys Lys Asn Gly Arg Cys Val Pro 
1               5                   10                  15      


Asn Tyr Tyr Leu Cys Asp Gly Val Asp Asp Cys His Asp Asn Ser Asp 
            20                  25                  30          


Glu Gln Leu Cys Gly Thr Leu Asn Asn Thr Cys Ser Ser Ser Ala Phe 
        35                  40                  45              


Thr Cys Gly His Gly Glu Cys Ile Pro Ala His Trp Arg Cys Asp Lys 
    50                  55                  60                  


Arg Asn Asp Cys Val Asp Gly Ser Asp Glu His Asn Cys Pro Thr His 
65                  70                  75                  80  


Ala Pro Ala Ser Cys Leu Asp Thr Gln Tyr Thr Cys Asp Asn His Gln 
                85                  90                  95      


Cys Ile Ser Lys Asn Trp Val Cys Asp Thr Asp Asn Asp Cys Gly Asp 
            100                 105                 110         


Gly Ser Asp Glu Lys Asn Cys Asn Ser Thr Glu Thr Cys Gln Pro Ser 
        115                 120                 125             


Gln Phe Asn Cys Pro Asn His Arg Cys Ile Asp Leu Ser Phe Val Cys 
    130                 135                 140                 


Asp Gly Asp Lys Asp Cys Val Asp Gly Ser Asp Glu Val Gly Cys Val 
145                 150                 155                 160 


Leu Asn Cys Thr Ala Ser Gln Phe Lys Cys Ala Ser Gly Asp Lys Cys 
                165                 170                 175     


Ile Gly Val Thr Asn Arg Cys Asp Gly Val Phe Asp Cys Ser Asp Asn 
            180                 185                 190         


Ser Asp Glu Ala Gly Cys Pro Thr Arg Pro Pro Gly Met Cys His Ser 
        195                 200                 205             


Asp Glu Phe Gln Cys Gln Glu Asp Gly Ile Cys Ile Pro Asn Phe Trp 
    210                 215                 220                 


Glu Cys Asp Gly His Pro Asp Cys Leu Tyr Gly Ser Asp Glu His Asn 
225                 230                 235                 240 


Ala Cys Val Pro Lys Thr Cys Pro Ser Ser Tyr Phe His Cys Asp Asn 
                245                 250                 255     


Gly Asn Cys Ile His Arg Ala Trp Leu Cys Asp Arg Asp Asn Asp Cys 
            260                 265                 270         


Gly Asp Met Ser Asp Glu Lys Asp Cys Pro Thr Gln Pro Phe Arg Cys 
        275                 280                 285             


Pro Ser Trp Gln Trp Gln Cys Leu Gly His Asn Ile Cys Val Asn Leu 
    290                 295                 300                 


Ser Val Val Cys Asp Gly Ile Phe Asp Cys Pro Asn Gly Thr Asp Glu 
305                 310                 315                 320 


Ser Pro Leu Cys Asn Gly Asn Ser Cys Ser Asp Phe Asn Gly Gly Cys 
                325                 330                 335     


Thr His Glu Cys Val Gln Glu Pro Phe Gly Ala Lys Cys Leu Cys Pro 
            340                 345                 350         


Leu Gly Phe Leu Leu Ala Asn Asp Ser Lys Thr Cys Glu Asp Ile Asp 
        355                 360                 365             


Glu Cys Asp Ile Leu Gly Ser Cys Ser Gln His Cys Tyr Asn Met Arg 
    370                 375                 380                 


Gly Ser Phe Arg Cys Ser Cys Asp Thr Gly Tyr Met Leu Glu Ser Asp 
385                 390                 395                 400 


Gly Arg Thr Cys Lys Val Thr Ala Ser Glu Ser Leu Leu Leu Leu Val 
                405                 410                 415     


Ala Ser Gln Asn Lys Ile Ile Ala Asp Ser Val Thr Ser Gln Val His 
            420                 425                 430         


Asn Ile Tyr Ser Leu Val Glu Asn Gly Ser Tyr Ile Val Ala Val Asp 
        435                 440                 445             


Phe Asp Ser Ile Ser Gly Arg Ile Phe Trp Ser Asp Ala Thr Gln Gly 
    450                 455                 460                 


Lys Thr Trp Ser Ala Phe Gln Asn Gly Thr Asp Arg Arg Val Val Phe 
465                 470                 475                 480 


Asp Ser Ser Ile Ile Leu Thr Glu Thr Ile Ala Ile Asp Trp Val Gly 
                485                 490                 495     


Arg Asn Leu Tyr Trp Thr Asp Tyr Ala Leu Glu Thr Ile Glu Val Ser 
            500                 505                 510         


Lys Ile Asp Gly Ser His Arg Thr Val Leu Ile Ser Lys Asn Leu Thr 
        515                 520                 525             


Asn Pro Arg Gly Leu Ala Leu Asp Pro Arg Met Asn Glu His Leu Leu 
    530                 535                 540                 


Phe Trp Ser Asp Trp Gly His His Pro Arg Ile Glu Arg Ala Ser Met 
545                 550                 555                 560 


Asp Gly Ser Met Arg Thr Val Ile Val Gln Asp Lys Ile Phe Trp Pro 
                565                 570                 575     


Cys Gly Leu Thr Ile Asp Tyr Pro Asn Arg Leu Leu Tyr Phe Met Asp 
            580                 585                 590         


Ser Tyr Leu Asp Tyr Met Asp Phe Cys Asp Tyr Asn Gly His His Arg 
        595                 600                 605             


Arg Gln Val Ile Ala Ser Asp Leu Ile Ile Arg His Pro Tyr Ala Leu 
    610                 615                 620                 


Thr Leu Phe Glu Asp Ser Val Tyr Trp Thr Asp Arg Ala Thr Arg Arg 
625                 630                 635                 640 


Val Met Arg Ala Asn Lys Trp His Gly Gly Asn Gln Ser Val Val Met 
                645                 650                 655     


Tyr Asn Ile Gln Trp Pro Leu Gly Ile Val Ala Val His Pro Ser Lys 
            660                 665                 670         


Gln Pro Asn Ser Val Asn Pro Cys Ala Phe Ser Arg Cys Ser His Leu 
        675                 680                 685             


Cys Leu Leu Ser Ser Gln Gly Pro His Phe Tyr Ser Cys Val Cys Pro 
    690                 695                 700                 


Ser Gly Trp Ser Leu Ser Pro Asp Leu Leu Asn Cys Leu Arg Asp Asp 
705                 710                 715                 720 


Gln Pro Phe Leu Ile Thr Val Arg Gln His Ile Ile Phe Gly Ile Ser 
                725                 730                 735     


Leu Asn Pro Glu Val Lys Ser Asn Asp Ala Met Val Pro Ile Ala Gly 
            740                 745                 750         


Ile Gln Asn Gly Leu Asp Val Glu Phe Asp Asp Ala Glu Gln Tyr Ile 
        755                 760                 765             


Tyr Trp Val Glu Asn Pro Gly Glu Ile His Arg Val Lys Thr Asp Gly 
    770                 775                 780                 


Thr Asn Arg Thr Val Phe Ala Ser Ile Ser Met Val Gly Pro Ser Met 
785                 790                 795                 800 


Asn Leu Ala Leu Asp Trp Ile Ser Arg Asn Leu Tyr Ser Thr Asn Pro 
                805                 810                 815     


Arg Thr Gln Ser Ile Glu Val Leu Thr Leu His Gly Asp Ile Arg Tyr 
            820                 825                 830         


Arg Lys Thr Leu Ile Ala Asn Asp Gly Thr Ala Leu Gly Val Gly Phe 
        835                 840                 845             


Pro Ile Gly Ile Thr Val Asp Pro Ala Arg Gly Lys Leu Tyr Trp Ser 
    850                 855                 860                 


Asp Gln Gly Thr Asp Ser Gly Val Pro Ala Lys Ile Ala Ser Ala Asn 
865                 870                 875                 880 


Met Asp Gly Thr Ser Val Lys Thr Leu Phe Thr Gly Asn Leu Glu His 
                885                 890                 895     


Leu Glu Cys Val Thr Leu Asp Ile Glu Glu Gln Lys Leu Tyr Trp Ala 
            900                 905                 910         


Val Thr Gly Arg Gly Val Ile Glu Arg Gly Asn Val Asp Gly Thr Asp 
        915                 920                 925             


Arg Met Ile Leu Val His Gln Leu Ser His Pro Trp Gly Ile Ala Val 
    930                 935                 940                 


His Asp Ser Phe Leu Tyr Tyr Thr Asp Glu Gln Tyr Glu Val Ile Glu 
945                 950                 955                 960 


Arg Val Asp Lys Ala Thr Gly Ala Asn Lys Ile Val Leu Arg Asp Asn 
                965                 970                 975     


Val Pro Asn Leu Arg Gly Leu Gln Val Tyr His Arg Arg Asn Ala Ala 
            980                 985                 990         


Glu Ser Ser Asn Gly Cys Ser Asn  Asn Met Asn Ala Cys  Gln Gln Ile 
        995                 1000                 1005             


Cys Leu  Pro Val Pro Gly Gly  Leu Phe Ser Cys Ala  Cys Ala Thr 
    1010                 1015                 1020             


Gly Phe  Lys Leu Asn Pro Asp  Asn Arg Ser Cys Ser  Pro Tyr Asn 
    1025                 1030                 1035             


Ser Phe  Ile Val Val Ser Met  Leu Ser Ala Ile Arg  Gly Phe Ser 
    1040                 1045                 1050             


Leu Glu  Leu Ser Asp His Ser  Glu Thr Met Val Pro  Val Ala Gly 
    1055                 1060                 1065             


Gln Gly  Arg Asn Ala Leu His  Val Asp Val Asp Val  Ser Ser Gly 
    1070                 1075                 1080             


Phe Ile  Tyr Trp Cys Asp Phe  Ser Ser Ser Val Ala  Ser Asp Asn 
    1085                 1090                 1095             


Ala Ile  Arg Arg Ile Lys Pro  Asp Gly Ser Ser Leu  Met Asn Ile 
    1100                 1105                 1110             


Val Thr  His Gly Ile Gly Glu  Asn Gly Val Arg Gly  Ile Ala Val 
    1115                 1120                 1125             


Asp Trp  Val Ala Gly Asn Leu  Tyr Phe Thr Asn Ala  Phe Val Ser 
    1130                 1135                 1140             


Glu Thr  Leu Ile Glu Val Leu  Arg Ile Asn Thr Thr  Tyr Arg Arg 
    1145                 1150                 1155             


Val Leu  Leu Lys Val Thr Val  Asp Met Pro Arg His  Ile Val Val 
    1160                 1165                 1170             


Asp Pro  Lys Asn Arg Tyr Leu  Phe Trp Ala Asp Tyr  Gly Gln Arg 
    1175                 1180                 1185             


Pro Lys  Ile Glu Arg Ser Phe  Leu Asp Cys Thr Asn  Arg Thr Val 
    1190                 1195                 1200             


Leu Val  Ser Glu Gly Ile Val  Thr Pro Arg Gly Leu  Ala Val Asp 
    1205                 1210                 1215             


Arg Ser  Asp Gly Tyr Val Tyr  Trp Val Asp Asp Ser  Leu Asp Ile 
    1220                 1225                 1230             


Ile Ala  Arg Ile Arg Ile Asn  Gly Glu Asn Ser Glu  Val Ile Arg 
    1235                 1240                 1245             


Tyr Gly  Ser Arg Tyr Pro Thr  Pro Tyr Gly Ile Thr  Val Phe Glu 
    1250                 1255                 1260             


Asn Ser  Ile Ile Trp Val Asp  Arg Asn Leu Lys Lys  Ile Phe Gln 
    1265                 1270                 1275             


Ala Ser  Lys Glu Pro Glu Asn  Thr Glu Pro Pro Thr  Val Ile Arg 
    1280                 1285                 1290             


Asp Asn  Ile Asn Trp Leu Arg  Asp Val Thr Ile Phe  Asp Lys Gln 
    1295                 1300                 1305             


Val Gln  Pro Arg Ser Pro Ala  Glu Val Asn Asn Asn  Pro Cys Leu 
    1310                 1315                 1320             


Glu Asn  Asn Gly Gly Cys Ser  His Leu Cys Phe Ala  Leu Pro Gly 
    1325                 1330                 1335             


Leu His  Thr Pro Lys Cys Asp  Cys Ala Phe Gly Thr  Leu Gln Ser 
    1340                 1345                 1350             


Asp Gly  Lys Asn Cys Ala Ile  Ser Thr Glu Asn Phe  Leu Ile Phe 
    1355                 1360                 1365             


Ala Leu  Ser Asn Ser Leu Arg  Ser Leu His Leu Asp  Pro Glu Asn 
    1370                 1375                 1380             


His Ser  Pro Pro Phe Gln Thr  Ile Asn Val Glu Arg  Thr Val Met 
    1385                 1390                 1395             


Ser Leu  Asp Tyr Asp Ser Val  Ser Asp Arg Ile Tyr  Phe Thr Gln 
    1400                 1405                 1410             


Asn Leu  Ala Ser Gly Val Gly  Gln Ile Ser Tyr Ala  Thr Leu Ser 
    1415                 1420                 1425             


Ser Gly  Ile His Thr Pro Thr  Val Ile Ala Ser Gly  Ile Gly Thr 
    1430                 1435                 1440             


Ala Asp  Gly Ile Ala Phe Asp  Trp Ile Thr Arg Arg  Ile Tyr Tyr 
    1445                 1450                 1455             


Ser Asp  Tyr Leu Asn Gln Met  Ile Asn Ser Met Ala  Glu Asp Gly 
    1460                 1465                 1470             


Ser Asn  Arg Thr Val Ile Ala  Arg Val Pro Lys Pro  Arg Ala Ile 
    1475                 1480                 1485             


Val Leu  Asp Pro Cys Gln Gly  Tyr Leu Tyr Trp Ala  Asp Trp Asp 
    1490                 1495                 1500             


Thr His  Ala Lys Ile Glu Arg  Ala Thr Leu Gly Gly  Asn Phe Arg 
    1505                 1510                 1515             


<210>  10
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  10

Ile Val Asn Ser Ser Leu Val Met Pro Ser Gly Leu Thr Leu Asp Tyr 
1               5                   10                  15      


Glu Glu Asp Leu Leu Tyr Trp Val Asp Ala Ser Leu Gln Arg Ile Glu 
            20                  25                  30          


Arg Ser Thr Leu Thr Gly Val Asp Arg Glu Val Ile Val Asn Ala Ala 
        35                  40                  45              


Val His Ala Phe Gly Leu Thr Leu Tyr Gly Gln Tyr Ile Tyr Trp Thr 
    50                  55                  60                  


Asp Leu Tyr Thr Gln Arg Ile Tyr Arg Ala Asn Lys Tyr Asp Gly Ser 
65                  70                  75                  80  


Gly Gln Ile Ala Met Thr Thr Asn Leu Leu Ser Gln Pro Arg Gly Ile 
                85                  90                  95      


Asn Thr Val Val Lys Asn Gln Lys Gln Gln Cys Asn Asn Pro Cys Glu 
            100                 105                 110         


Gln Phe Asn Gly Gly Cys Ser His Ile Cys Ala Pro Gly Pro Asn Gly 
        115                 120                 125             


Ala Glu Cys Gln Cys Pro His Glu Gly Asn Trp Tyr Leu Ala Asn Asn 
    130                 135                 140                 


Arg Lys His Cys Ile Val Asp Asn Gly Glu Arg Cys Gly Ala Ser Ser 
145                 150                 155                 160 


Phe Thr Cys Ser Asn Gly Arg Cys Ile Ser Glu Glu Trp Lys Cys Asp 
                165                 170                 175     


Asn Asp Asn Asp Cys Gly Asp Gly Ser Asp Glu Met Glu Ser Val Cys 
            180                 185                 190         


Ala Leu His Thr Cys Ser Pro Thr Ala Phe Thr Cys Ala Asn Gly Arg 
        195                 200                 205             


Cys Val Gln Tyr Ser Tyr Arg Cys Asp Tyr Tyr Asn Asp Cys Gly Asp 
    210                 215                 220                 


Gly Ser Asp Glu Ala Gly Cys Leu Phe Arg Asp Cys Asn Ala Thr Thr 
225                 230                 235                 240 


Glu Phe Met Cys Asn Asn Arg Arg Cys Ile Pro Arg Glu Phe Ile Cys 
                245                 250                 255     


Asn Gly Val Asp Asn Cys His Asp Asn Asn Thr Ser Asp Glu Lys Asn 
            260                 265                 270         


Cys Pro Asp Arg Thr Cys Gln Ser Gly Tyr Thr Lys Cys His Asn Ser 
        275                 280                 285             


Asn Ile Cys Ile Pro Arg Val Tyr Leu Cys Asp Gly Asp Asn Asp Cys 
    290                 295                 300                 


Gly Asp Asn Ser Asp Glu Asn Pro Thr Tyr Cys Thr Thr His Thr Cys 
305                 310                 315                 320 


Ser Ser Ser Glu Phe Gln Cys Ala Ser Gly Arg Cys Ile Pro Gln His 
                325                 330                 335     


Trp Tyr Cys Asp Gln Glu Thr Asp Cys Phe Asp Ala Ser Asp Glu Pro 
            340                 345                 350         


Ala Ser Cys Gly His Ser Glu Arg Thr Cys Leu Ala Asp Glu Phe Lys 
        355                 360                 365             


Cys Asp Gly Gly Arg Cys Ile Pro Ser Glu Trp Ile Cys Asp Gly Asp 
    370                 375                 380                 


Asn Asp Cys Gly Asp Met Ser Asp Glu Asp Lys Arg His Gln Cys Gln 
385                 390                 395                 400 


Asn Gln Asn Cys Ser Asp Ser Glu Phe Leu Cys Val Asn Asp Arg Pro 
                405                 410                 415     


Pro Asp Arg Arg Cys Ile Pro Gln Ser Trp Val Cys Asp Gly Asp Val 
            420                 425                 430         


Asp Cys Thr Asp Gly Tyr Asp Glu Asn Gln Asn Cys Thr Arg Arg Thr 
        435                 440                 445             


Cys Ser Glu Asn Glu Phe Thr Cys Gly Tyr Gly Leu Cys Ile Pro Lys 
    450                 455                 460                 


Ile Phe Arg Cys Asp Arg His Asn Asp Cys Gly Asp Tyr Ser Asp Glu 
465                 470                 475                 480 


Arg Gly Cys Leu Tyr Gln Thr Cys Gln Gln Asn Gln Phe Thr Cys Gln 
                485                 490                 495     


Asn Gly Arg Cys Ile Ser Lys Thr Phe Val Cys Asp Glu Asp Asn Asp 
            500                 505                 510         


Cys Gly Asp Gly Ser Asp Glu Leu Met His Leu Cys His Thr Pro Glu 
        515                 520                 525             


Pro Thr Cys Pro Pro His Glu Phe Lys Cys Asp Asn Gly Arg Cys Ile 
    530                 535                 540                 


Glu Met Met Lys Leu Cys Asn His Leu Asp Asp Cys Leu Asp Asn Ser 
545                 550                 555                 560 


Asp Glu Lys Gly Cys 
                565 


<210>  11
<211>  1504
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Ile Asp Glu Cys Thr Glu Met Pro Phe Val Cys Ser Gln Lys Cys 
1               5                   10                  15      


Glu Asn Val Ile Gly Ser Tyr Ile Cys Lys Cys Ala Pro Gly Tyr Leu 
            20                  25                  30          


Arg Glu Pro Asp Gly Lys Thr Cys Arg Gln Asn Ser Asn Ile Glu Pro 
        35                  40                  45              


Tyr Leu Ile Phe Ser Asn Arg Tyr Tyr Leu Arg Asn Leu Thr Ile Asp 
    50                  55                  60                  


Gly Tyr Phe Tyr Ser Leu Ile Leu Glu Gly Leu Asp Asn Val Val Ala 
65                  70                  75                  80  


Leu Asp Phe Asp Arg Val Glu Lys Arg Leu Tyr Trp Ile Asp Thr Gln 
                85                  90                  95      


Arg Gln Val Ile Glu Arg Met Phe Leu Asn Lys Thr Asn Lys Glu Thr 
            100                 105                 110         


Ile Ile Asn His Arg Leu Pro Ala Ala Glu Ser Leu Ala Val Asp Trp 
        115                 120                 125             


Val Ser Arg Lys Leu Tyr Trp Leu Asp Ala Arg Leu Asp Gly Leu Phe 
    130                 135                 140                 


Val Ser Asp Leu Asn Gly Gly His Arg Arg Met Leu Ala Gln His Cys 
145                 150                 155                 160 


Val Asp Ala Asn Asn Thr Phe Cys Phe Asp Asn Pro Arg Gly Leu Ala 
                165                 170                 175     


Leu His Pro Gln Tyr Gly Tyr Leu Tyr Trp Ala Asp Trp Gly His Arg 
            180                 185                 190         


Ala Tyr Ile Gly Arg Val Gly Met Asp Gly Thr Asn Lys Ser Val Ile 
        195                 200                 205             


Ile Ser Thr Lys Leu Glu Trp Pro Asn Gly Ile Thr Ile Asp Tyr Thr 
    210                 215                 220                 


Asn Asp Leu Leu Tyr Trp Ala Asp Ala His Leu Gly Tyr Ile Glu Tyr 
225                 230                 235                 240 


Ser Asp Leu Glu Gly His His Arg His Thr Val Tyr Asp Gly Ala Leu 
                245                 250                 255     


Pro His Pro Phe Ala Ile Thr Ile Phe Glu Asp Thr Ile Tyr Trp Thr 
            260                 265                 270         


Asp Trp Asn Thr Arg Thr Val Glu Lys Gly Asn Lys Tyr Asp Gly Ser 
        275                 280                 285             


Asn Arg Gln Thr Leu Val Asn Thr Thr His Arg Pro Phe Asp Ile His 
    290                 295                 300                 


Val Tyr His Pro Tyr Arg Gln Pro Ile Val Ser Asn Pro Cys Gly Thr 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Leu Cys Leu Ile Lys Pro Gly Gly Lys 
                325                 330                 335     


Gly Phe Thr Cys Glu Cys Pro Asp Asp Phe Arg Thr Leu Gln Leu Ser 
            340                 345                 350         


Gly Ser Thr Tyr Cys Met Pro Met Cys Ser Ser Thr Gln Phe Leu Cys 
        355                 360                 365             


Ala Asn Asn Glu Lys Cys Ile Pro Ile Trp Trp Lys Cys Asp Gly Gln 
    370                 375                 380                 


Lys Asp Cys Ser Asp Gly Ser Asp Glu Leu Ala Leu Cys Pro Gln Arg 
385                 390                 395                 400 


Phe Cys Arg Leu Gly Gln Phe Gln Cys Ser Asp Gly Asn Cys Thr Ser 
                405                 410                 415     


Pro Gln Thr Leu Cys Asn Ala His Gln Asn Cys Pro Asp Gly Ser Asp 
            420                 425                 430         


Glu Asp Arg Leu Leu Cys Glu Asn His His Cys Asp Ser Asn Glu Trp 
        435                 440                 445             


Gln Cys Ala Asn Lys Arg Cys Ile Pro Glu Ser Trp Gln Cys Asp Thr 
    450                 455                 460                 


Phe Asn Asp Cys Glu Asp Asn Ser Asp Glu Asp Ser Ser His Cys Ala 
465                 470                 475                 480 


Ser Arg Thr Cys Arg Pro Gly Gln Phe Arg Cys Ala Asn Gly Arg Cys 
                485                 490                 495     


Ile Pro Gln Ala Trp Lys Cys Asp Val Asp Asn Asp Cys Gly Asp His 
            500                 505                 510         


Ser Asp Glu Pro Ile Glu Glu Cys Met Ser Ser Ala His Leu Cys Asp 
        515                 520                 525             


Asn Phe Thr Glu Phe Ser Cys Lys Thr Asn Tyr Arg Cys Ile Pro Lys 
    530                 535                 540                 


Trp Ala Val Cys Asn Gly Val Asp Asp Cys Arg Asp Asn Ser Asp Glu 
545                 550                 555                 560 


Gln Gly Cys Glu Glu Arg Thr Cys His Pro Val Gly Asp Phe Arg Cys 
                565                 570                 575     


Lys Asn His His Cys Ile Pro Leu Arg Trp Gln Cys Asp Gly Gln Asn 
            580                 585                 590         


Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Ala Pro Arg Glu Cys 
        595                 600                 605             


Thr Glu Ser Glu Phe Arg Cys Val Asn Gln Gln Cys Ile Pro Ser Arg 
    610                 615                 620                 


Trp Ile Cys Asp His Tyr Asn Asp Cys Gly Asp Asn Ser Asp Glu Arg 
625                 630                 635                 640 


Asp Cys Glu Met Arg Thr Cys His Pro Glu Tyr Phe Gln Cys Thr Ser 
                645                 650                 655     


Gly His Cys Val His Ser Glu Leu Lys Cys Asp Gly Ser Ala Asp Cys 
            660                 665                 670         


Leu Asp Ala Ser Asp Glu Ala Asp Cys Pro Thr Arg Phe Pro Asp Gly 
        675                 680                 685             


Ala Tyr Cys Gln Ala Thr Met Phe Glu Cys Lys Asn His Val Cys Ile 
    690                 695                 700                 


Pro Pro Tyr Trp Lys Cys Asp Gly Asp Asp Asp Cys Gly Asp Gly Ser 
705                 710                 715                 720 


Asp Glu Glu Leu His Leu Cys Leu Asp Val Pro Cys Asn Ser Pro Asn 
                725                 730                 735     


Arg Phe Arg Cys Asp Asn Asn Arg Cys Ile Tyr Ser His Glu Val Cys 
            740                 745                 750         


Asn Gly Val Asp Asp Cys Gly Asp Gly Thr Asp Glu Thr Glu Glu His 
        755                 760                 765             


Cys Arg Lys Pro Thr Pro Lys Pro Cys Thr Glu Tyr Glu Tyr Lys Cys 
    770                 775                 780                 


Gly Asn Gly His Cys Ile Pro His Asp Asn Val Cys Asp Asp Ala Asp 
785                 790                 795                 800 


Asp Cys Gly Asp Trp Ser Asp Glu Leu Gly Cys Asn Lys Gly Lys Glu 
                805                 810                 815     


Arg Thr Cys Ala Glu Asn Ile Cys Glu Gln Asn Cys Thr Gln Leu Asn 
            820                 825                 830         


Glu Gly Gly Phe Ile Cys Ser Cys Thr Ala Gly Phe Glu Thr Asn Val 
        835                 840                 845             


Phe Asp Arg Thr Ser Cys Leu Asp Ile Asn Glu Cys Glu Gln Phe Gly 
    850                 855                 860                 


Thr Cys Pro Gln His Cys Arg Asn Thr Lys Gly Ser Tyr Glu Cys Val 
865                 870                 875                 880 


Cys Ala Asp Gly Phe Thr Ser Met Ser Asp Arg Pro Gly Lys Arg Cys 
                885                 890                 895     


Ala Ala Glu Gly Ser Ser Pro Leu Leu Leu Leu Pro Asp Asn Val Arg 
            900                 905                 910         


Ile Arg Lys Tyr Asn Leu Ser Ser Glu Arg Phe Ser Glu Tyr Leu Gln 
        915                 920                 925             


Asp Glu Glu Tyr Ile Gln Ala Val Asp Tyr Asp Trp Asp Pro Lys Asp 
    930                 935                 940                 


Ile Gly Leu Ser Val Val Tyr Tyr Thr Val Arg Gly Glu Gly Ser Arg 
945                 950                 955                 960 


Phe Gly Ala Ile Lys Arg Ala Tyr Ile Pro Asn Phe Glu Ser Gly Arg 
                965                 970                 975     


Asn Asn Leu Val Gln Glu Val Asp Leu Lys Leu Lys Tyr Val Met Gln 
            980                 985                 990         


Pro Asp Gly Ile Ala Val Asp Trp  Val Gly Arg His Ile  Tyr Trp Ser 
        995                 1000                 1005             


Asp Val  Lys Asn Lys Arg Ile  Glu Val Ala Lys Leu  Asp Gly Arg 
    1010                 1015                 1020             


Tyr Arg  Lys Trp Leu Ile Ser  Thr Asp Leu Asp Gln  Pro Ala Ala 
    1025                 1030                 1035             


Ile Ala  Val Asn Pro Lys Leu  Gly Leu Met Phe Trp  Thr Asp Trp 
    1040                 1045                 1050             


Gly Lys  Glu Pro Lys Ile Glu  Ser Ala Trp Met Asn  Gly Glu Asp 
    1055                 1060                 1065             


Arg Asn  Ile Leu Val Phe Glu  Asp Leu Gly Trp Pro  Thr Gly Leu 
    1070                 1075                 1080             


Ser Ile  Asp Tyr Leu Asn Asn  Asp Arg Ile Tyr Trp  Ser Asp Phe 
    1085                 1090                 1095             


Lys Glu  Asp Val Ile Glu Thr  Ile Lys Tyr Asp Gly  Thr Asp Arg 
    1100                 1105                 1110             


Arg Val  Ile Ala Lys Glu Ala  Met Asn Pro Tyr Ser  Leu Asp Ile 
    1115                 1120                 1125             


Phe Glu  Asp Gln Leu Tyr Trp  Ile Ser Lys Glu Lys  Gly Glu Val 
    1130                 1135                 1140             


Trp Lys  Gln Asn Lys Phe Gly  Gln Gly Lys Lys Glu  Lys Thr Leu 
    1145                 1150                 1155             


Val Val  Asn Pro Trp Leu Thr  Gln Val Arg Ile Phe  His Gln Leu 
    1160                 1165                 1170             


Arg Tyr  Asn Lys Ser Val Pro  Asn Leu Cys Lys Gln  Ile Cys Ser 
    1175                 1180                 1185             


His Leu  Cys Leu Leu Arg Pro  Gly Gly Tyr Ser Cys  Ala Cys Pro 
    1190                 1195                 1200             


Gln Gly  Ser Ser Phe Ile Glu  Gly Ser Thr Thr Glu  Cys Asp Ala 
    1205                 1210                 1215             


Ala Ile  Glu Leu Pro Ile Asn  Leu Pro Pro Pro Cys  Arg Cys Met 
    1220                 1225                 1230             


His Gly  Gly Asn Cys Tyr Phe  Asp Glu Thr Asp Leu  Pro Lys Cys 
    1235                 1240                 1245             


Lys Cys  Pro Ser Gly Tyr Thr  Gly Lys Tyr Cys Glu  Met Ala Phe 
    1250                 1255                 1260             


Ser Lys  Gly Ile Ser Pro Gly  Thr Thr Ala Val Ala  Val Leu Leu 
    1265                 1270                 1275             


Thr Ile  Leu Leu Ile Val Val  Ile Gly Ala Leu Ala  Ile Ala Gly 
    1280                 1285                 1290             


Phe Phe  His Tyr Arg Arg Thr  Gly Ser Leu Leu Pro  Ala Leu Pro 
    1295                 1300                 1305             


Lys Leu  Pro Ser Leu Ser Ser  Leu Val Lys Pro Ser  Glu Asn Gly 
    1310                 1315                 1320             


Asn Gly  Val Thr Phe Arg Ser  Gly Ala Asp Leu Asn  Met Asp Ile 
    1325                 1330                 1335             


Gly Val  Ser Gly Phe Gly Pro  Glu Thr Ala Ile Asp  Arg Ser Met 
    1340                 1345                 1350             


Ala Met  Ser Glu Asp Phe Val  Met Glu Met Gly Lys  Gln Pro Ile 
    1355                 1360                 1365             


Ile Phe  Glu Asn Pro Met Tyr  Ser Ala Arg Asp Ser  Ala Val Lys 
    1370                 1375                 1380             


Val Val  Gln Pro Ile Gln Val  Thr Val Ser Glu Asn  Val Asp Asn 
    1385                 1390                 1395             


Lys Asn  Tyr Gly Ser Pro Ile  Asn Pro Ser Glu Ile  Val Pro Glu 
    1400                 1405                 1410             


Thr Asn  Pro Thr Ser Pro Ala  Ala Asp Gly Thr Gln  Val Thr Lys 
    1415                 1420                 1425             


Trp Asn  Leu Phe Lys Arg Lys  Ser Lys Gln Thr Thr  Asn Phe Glu 
    1430                 1435                 1440             


Asn Pro  Ile Tyr Ala Gln Met  Glu Asn Glu Gln Lys  Glu Ser Val 
    1445                 1450                 1455             


Ala Ala  Thr Pro Pro Pro Ser  Pro Ser Leu Pro Ala  Lys Pro Lys 
    1460                 1465                 1470             


Pro Pro  Ser Arg Arg Asp Pro  Thr Pro Thr Tyr Ser  Ala Thr Glu 
    1475                 1480                 1485             


Asp Thr  Phe Lys Asp Thr Ala  Asn Leu Val Lys Glu  Asp Ser Glu 
    1490                 1495                 1500             


Val 
    


<210>  12
<211>  2515
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Asp Ser Ala His Phe Arg Cys Gly Ser Gly His Cys Ile Pro Ala 
1               5                   10                  15      


Asp Trp Arg Cys Asp Gly Thr Lys Asp Cys Ser Asp Asp Ala Asp Glu 
            20                  25                  30          


Ile Gly Cys Ala Val Val Thr Cys Gln Gln Gly Tyr Phe Lys Cys Gln 
        35                  40                  45              


Ser Glu Gly Gln Cys Ile Pro Asn Ser Trp Val Cys Asp Gln Asp Gln 
    50                  55                  60                  


Asp Cys Asp Asp Gly Ser Asp Glu Arg Gln Asp Cys Ser Gln Ser Thr 
65                  70                  75                  80  


Cys Ser Ser His Gln Ile Thr Cys Ser Asn Gly Gln Cys Ile Pro Ser 
                85                  90                  95      


Glu Tyr Arg Cys Asp His Val Arg Asp Cys Pro Asp Gly Ala Asp Glu 
            100                 105                 110         


Asn Asp Cys Gln Tyr Pro Thr Cys Glu Gln Leu Thr Cys Asp Asn Gly 
        115                 120                 125             


Ala Cys Tyr Asn Thr Ser Gln Lys Cys Asp Trp Lys Val Asp Cys Arg 
    130                 135                 140                 


Asp Ser Ser Asp Glu Ile Asn Cys Thr Glu Ile Cys Leu His Asn Glu 
145                 150                 155                 160 


Phe Ser Cys Gly Asn Gly Glu Cys Ile Pro Arg Ala Tyr Val Cys Asp 
                165                 170                 175     


His Asp Asn Asp Cys Gln Asp Gly Ser Asp Glu His Ala Cys Asn Tyr 
            180                 185                 190         


Pro Thr Cys Gly Gly Tyr Gln Phe Thr Cys Pro Ser Gly Arg Cys Ile 
        195                 200                 205             


Tyr Gln Asn Trp Val Cys Asp Gly Glu Asp Asp Cys Lys Asp Asn Gly 
    210                 215                 220                 


Asp Glu Asp Gly Cys Glu Ser Gly Pro His Asp Val His Lys Cys Ser 
225                 230                 235                 240 


Pro Arg Glu Trp Ser Cys Pro Glu Ser Gly Arg Cys Ile Ser Ile Tyr 
                245                 250                 255     


Lys Val Cys Asp Gly Ile Leu Asp Cys Pro Gly Arg Glu Asp Glu Asn 
            260                 265                 270         


Asn Thr Ser Thr Gly Lys Tyr Cys Ser Met Thr Leu Cys Ser Ala Leu 
        275                 280                 285             


Asn Cys Gln Tyr Gln Cys His Glu Thr Pro Tyr Gly Gly Ala Cys Phe 
    290                 295                 300                 


Cys Pro Pro Gly Tyr Ile Ile Asn His Asn Asp Ser Arg Thr Cys Val 
305                 310                 315                 320 


Glu Phe Asp Asp Cys Gln Ile Trp Gly Ile Cys Asp Gln Lys Cys Glu 
                325                 330                 335     


Ser Arg Pro Gly Arg His Leu Cys His Cys Glu Glu Gly Tyr Ile Leu 
            340                 345                 350         


Glu Arg Gly Gln Tyr Cys Lys Ala Asn Asp Ser Phe Gly Glu Ala Ser 
        355                 360                 365             


Ile Ile Phe Ser Asn Gly Arg Asp Leu Leu Ile Gly Asp Ile His Gly 
    370                 375                 380                 


Arg Ser Phe Arg Ile Leu Val Glu Ser Gln Asn Arg Gly Val Ala Val 
385                 390                 395                 400 


Gly Val Ala Phe His Tyr His Leu Gln Arg Val Phe Trp Thr Asp Thr 
                405                 410                 415     


Val Gln Asn Lys Val Phe Ser Val Asp Ile Asn Gly Leu Asn Ile Gln 
            420                 425                 430         


Glu Val Leu Asn Val Ser Val Glu Thr Pro Glu Asn Leu Ala Val Asp 
        435                 440                 445             


Trp Val Asn Asn Lys Ile Tyr Leu Val Glu Thr Lys Val Asn Arg Ile 
    450                 455                 460                 


Asp Met Val Asn Leu Asp Gly Ser Tyr Arg Val Thr Leu Ile Thr Glu 
465                 470                 475                 480 


Asn Leu Gly His Pro Arg Gly Ile Ala Val Asp Pro Thr Val Gly Tyr 
                485                 490                 495     


Leu Phe Phe Ser Asp Trp Glu Ser Leu Ser Gly Glu Pro Lys Leu Glu 
            500                 505                 510         


Arg Ala Phe Met Asp Gly Ser Asn Arg Lys Asp Leu Val Lys Thr Lys 
        515                 520                 525             


Leu Gly Trp Pro Ala Gly Val Thr Leu Asp Met Ile Ser Lys Arg Val 
    530                 535                 540                 


Tyr Trp Val Asp Ser Arg Phe Asp Tyr Ile Glu Thr Val Thr Tyr Asp 
545                 550                 555                 560 


Gly Ile Gln Arg Lys Thr Val Val His Gly Gly Ser Leu Ile Pro His 
                565                 570                 575     


Pro Phe Gly Val Ser Leu Phe Glu Gly Gln Val Phe Phe Thr Asp Trp 
            580                 585                 590         


Thr Lys Met Ala Val Leu Lys Ala Asn Lys Phe Thr Glu Thr Asn Pro 
        595                 600                 605             


Gln Val Tyr Tyr Gln Ala Ser Leu Arg Pro Tyr Gly Val Thr Val Tyr 
    610                 615                 620                 


His Ser Leu Arg Gln Pro Tyr Ala Thr Asn Pro Cys Lys Asp Asn Asn 
625                 630                 635                 640 


Gly Gly Cys Glu Gln Val Cys Val Leu Ser His Arg Thr Asp Asn Asp 
                645                 650                 655     


Gly Leu Gly Phe Arg Cys Lys Cys Thr Phe Gly Phe Gln Leu Asp Thr 
            660                 665                 670         


Asp Glu Arg His Cys Ile Ala Val Gln Asn Phe Leu Ile Phe Ser Ser 
        675                 680                 685             


Gln Val Ala Ile Arg Gly Ile Pro Phe Thr Leu Ser Thr Gln Glu Asp 
    690                 695                 700                 


Val Met Val Pro Val Ser Gly Asn Pro Ser Phe Phe Val Gly Ile Asp 
705                 710                 715                 720 


Phe Asp Ala Gln Asp Ser Thr Ile Phe Phe Ser Asp Met Ser Lys His 
                725                 730                 735     


Met Ile Phe Lys Gln Lys Ile Asp Gly Thr Gly Arg Glu Ile Leu Ala 
            740                 745                 750         


Ala Asn Arg Val Glu Asn Val Glu Ser Leu Ala Phe Asp Trp Ile Ser 
        755                 760                 765             


Lys Asn Leu Tyr Trp Thr Asp Ser His Tyr Lys Ser Ile Ser Val Met 
    770                 775                 780                 


Arg Leu Ala Asp Lys Thr Arg Arg Thr Val Val Gln Tyr Leu Asn Asn 
785                 790                 795                 800 


Pro Arg Ser Val Val Val His Pro Phe Ala Gly Tyr Leu Phe Phe Thr 
                805                 810                 815     


Asp Trp Phe Arg Pro Ala Lys Ile Met Arg Ala Trp Ser Asp Gly Ser 
            820                 825                 830         


His Leu Leu Pro Val Ile Asn Thr Thr Leu Gly Trp Pro Asn Gly Leu 
        835                 840                 845             


Ala Ile Asp Trp Ala Ala Ser Arg Leu Tyr Trp Val Asp Ala Tyr Phe 
    850                 855                 860                 


Asp Lys Ile Glu His Ser Thr Phe Asp Gly Leu Asp Arg Arg Arg Leu 
865                 870                 875                 880 


Gly His Ile Glu Gln Met Thr His Pro Phe Gly Leu Ala Ile Phe Gly 
                885                 890                 895     


Glu His Leu Phe Phe Thr Asp Trp Arg Leu Gly Ala Ile Ile Arg Val 
            900                 905                 910         


Arg Lys Ala Asp Gly Gly Glu Met Thr Val Ile Arg Ser Gly Ile Ala 
        915                 920                 925             


Tyr Ile Leu His Leu Lys Ser Tyr Asp Val Asn Ile Gln Thr Gly Ser 
    930                 935                 940                 


Asn Ala Cys Asn Gln Pro Thr His Pro Asn Gly Asp Cys Ser His Phe 
945                 950                 955                 960 


Cys Phe Pro Val Pro Asn Phe Gln Arg Val Cys Gly Cys Pro Tyr Gly 
                965                 970                 975     


Met Arg Leu Ala Ser Asn His Leu Thr Cys Glu Gly Asp Pro Thr Asn 
            980                 985                 990         


Glu Pro Pro Thr Glu Gln Cys Gly  Leu Phe Ser Phe Pro  Cys Lys Asn 
        995                 1000                 1005             


Gly Arg  Cys Val Pro Asn Tyr  Tyr Leu Cys Asp Gly  Val Asp Asp 
    1010                 1015                 1020             


Cys His  Asp Asn Ser Asp Glu  Gln Leu Cys Gly Thr  Leu Asn Asn 
    1025                 1030                 1035             


Thr Cys  Ser Ser Ser Ala Phe  Thr Cys Gly His Gly  Glu Cys Ile 
    1040                 1045                 1050             


Pro Ala  His Trp Arg Cys Asp  Lys Arg Asn Asp Cys  Val Asp Gly 
    1055                 1060                 1065             


Ser Asp  Glu His Asn Cys Pro  Thr His Ala Pro Ala  Ser Cys Leu 
    1070                 1075                 1080             


Asp Thr  Gln Tyr Thr Cys Asp  Asn His Gln Cys Ile  Ser Lys Asn 
    1085                 1090                 1095             


Trp Val  Cys Asp Thr Asp Asn  Asp Cys Gly Asp Gly  Ser Asp Glu 
    1100                 1105                 1110             


Lys Asn  Cys Asn Ser Thr Glu  Thr Cys Gln Pro Ser  Gln Phe Asn 
    1115                 1120                 1125             


Cys Pro  Asn His Arg Cys Ile  Asp Leu Ser Phe Val  Cys Asp Gly 
    1130                 1135                 1140             


Asp Lys  Asp Cys Val Asp Gly  Ser Asp Glu Val Gly  Cys Val Leu 
    1145                 1150                 1155             


Asn Cys  Thr Ala Ser Gln Phe  Lys Cys Ala Ser Gly  Asp Lys Cys 
    1160                 1165                 1170             


Ile Gly  Val Thr Asn Arg Cys  Asp Gly Val Phe Asp  Cys Ser Asp 
    1175                 1180                 1185             


Asn Ser  Asp Glu Ala Gly Cys  Pro Thr Arg Pro Pro  Gly Met Cys 
    1190                 1195                 1200             


His Ser  Asp Glu Phe Gln Cys  Gln Glu Asp Gly Ile  Cys Ile Pro 
    1205                 1210                 1215             


Asn Phe  Trp Glu Cys Asp Gly  His Pro Asp Cys Leu  Tyr Gly Ser 
    1220                 1225                 1230             


Asp Glu  His Asn Ala Cys Val  Pro Lys Thr Cys Pro  Ser Ser Tyr 
    1235                 1240                 1245             


Phe His  Cys Asp Asn Gly Asn  Cys Ile His Arg Ala  Trp Leu Cys 
    1250                 1255                 1260             


Asp Arg  Asp Asn Asp Cys Gly  Asp Met Ser Asp Glu  Lys Asp Cys 
    1265                 1270                 1275             


Pro Thr  Gln Pro Phe Arg Cys  Pro Ser Trp Gln Trp  Gln Cys Leu 
    1280                 1285                 1290             


Gly His  Asn Ile Cys Val Asn  Leu Ser Val Val Cys  Asp Gly Ile 
    1295                 1300                 1305             


Phe Asp  Cys Pro Asn Gly Thr  Asp Glu Ser Pro Leu  Cys Asn Gly 
    1310                 1315                 1320             


Asn Ser  Cys Ser Asp Phe Asn  Gly Gly Cys Thr His  Glu Cys Val 
    1325                 1330                 1335             


Gln Glu  Pro Phe Gly Ala Lys  Cys Leu Cys Pro Leu  Gly Phe Leu 
    1340                 1345                 1350             


Leu Ala  Asn Asp Ser Lys Thr  Cys Glu Asp Ile Asp  Glu Cys Asp 
    1355                 1360                 1365             


Ile Leu  Gly Ser Cys Ser Gln  His Cys Tyr Asn Met  Arg Gly Ser 
    1370                 1375                 1380             


Phe Arg  Cys Ser Cys Asp Thr  Gly Tyr Met Leu Glu  Ser Asp Gly 
    1385                 1390                 1395             


Arg Thr  Cys Lys Val Thr Ala  Ser Glu Ser Leu Leu  Leu Leu Val 
    1400                 1405                 1410             


Ala Ser  Gln Asn Lys Ile Ile  Ala Asp Ser Val Thr  Ser Gln Val 
    1415                 1420                 1425             


His Asn  Ile Tyr Ser Leu Val  Glu Asn Gly Ser Tyr  Ile Val Ala 
    1430                 1435                 1440             


Val Asp  Phe Asp Ser Ile Ser  Gly Arg Ile Phe Trp  Ser Asp Ala 
    1445                 1450                 1455             


Thr Gln  Gly Lys Thr Trp Ser  Ala Phe Gln Asn Gly  Thr Asp Arg 
    1460                 1465                 1470             


Arg Val  Val Phe Asp Ser Ser  Ile Ile Leu Thr Glu  Thr Ile Ala 
    1475                 1480                 1485             


Ile Asp  Trp Val Gly Arg Asn  Leu Tyr Trp Thr Asp  Tyr Ala Leu 
    1490                 1495                 1500             


Glu Thr  Ile Glu Val Ser Lys  Ile Asp Gly Ser His  Arg Thr Val 
    1505                 1510                 1515             


Leu Ile  Ser Lys Asn Leu Thr  Asn Pro Arg Gly Leu  Ala Leu Asp 
    1520                 1525                 1530             


Pro Arg  Met Asn Glu His Leu  Leu Phe Trp Ser Asp  Trp Gly His 
    1535                 1540                 1545             


His Pro  Arg Ile Glu Arg Ala  Ser Met Asp Gly Ser  Met Arg Thr 
    1550                 1555                 1560             


Val Ile  Val Gln Asp Lys Ile  Phe Trp Pro Cys Gly  Leu Thr Ile 
    1565                 1570                 1575             


Asp Tyr  Pro Asn Arg Leu Leu  Tyr Phe Met Asp Ser  Tyr Leu Asp 
    1580                 1585                 1590             


Tyr Met  Asp Phe Cys Asp Tyr  Asn Gly His His Arg  Arg Gln Val 
    1595                 1600                 1605             


Ile Ala  Ser Asp Leu Ile Ile  Arg His Pro Tyr Ala  Leu Thr Leu 
    1610                 1615                 1620             


Phe Glu  Asp Ser Val Tyr Trp  Thr Asp Arg Ala Thr  Arg Arg Val 
    1625                 1630                 1635             


Met Arg  Ala Asn Lys Trp His  Gly Gly Asn Gln Ser  Val Val Met 
    1640                 1645                 1650             


Tyr Asn  Ile Gln Trp Pro Leu  Gly Ile Val Ala Val  His Pro Ser 
    1655                 1660                 1665             


Lys Gln  Pro Asn Ser Val Asn  Pro Cys Ala Phe Ser  Arg Cys Ser 
    1670                 1675                 1680             


His Leu  Cys Leu Leu Ser Ser  Gln Gly Pro His Phe  Tyr Ser Cys 
    1685                 1690                 1695             


Val Cys  Pro Ser Gly Trp Ser  Leu Ser Pro Asp Leu  Leu Asn Cys 
    1700                 1705                 1710             


Leu Arg  Asp Asp Gln Pro Phe  Leu Ile Thr Val Arg  Gln His Ile 
    1715                 1720                 1725             


Ile Phe  Gly Ile Ser Leu Asn  Pro Glu Val Lys Ser  Asn Asp Ala 
    1730                 1735                 1740             


Met Val  Pro Ile Ala Gly Ile  Gln Asn Gly Leu Asp  Val Glu Phe 
    1745                 1750                 1755             


Asp Asp  Ala Glu Gln Tyr Ile  Tyr Trp Val Glu Asn  Pro Gly Glu 
    1760                 1765                 1770             


Ile His  Arg Val Lys Thr Asp  Gly Thr Asn Arg Thr  Val Phe Ala 
    1775                 1780                 1785             


Ser Ile  Ser Met Val Gly Pro  Ser Met Asn Leu Ala  Leu Asp Trp 
    1790                 1795                 1800             


Ile Ser  Arg Asn Leu Tyr Ser  Thr Asn Pro Arg Thr  Gln Ser Ile 
    1805                 1810                 1815             


Glu Val  Leu Thr Leu His Gly  Asp Ile Arg Tyr Arg  Lys Thr Leu 
    1820                 1825                 1830             


Ile Ala  Asn Asp Gly Thr Ala  Leu Gly Val Gly Phe  Pro Ile Gly 
    1835                 1840                 1845             


Ile Thr  Val Asp Pro Ala Arg  Gly Lys Leu Tyr Trp  Ser Asp Gln 
    1850                 1855                 1860             


Gly Thr  Asp Ser Gly Val Pro  Ala Lys Ile Ala Ser  Ala Asn Met 
    1865                 1870                 1875             


Asp Gly  Thr Ser Val Lys Thr  Leu Phe Thr Gly Asn  Leu Glu His 
    1880                 1885                 1890             


Leu Glu  Cys Val Thr Leu Asp  Ile Glu Glu Gln Lys  Leu Tyr Trp 
    1895                 1900                 1905             


Ala Val  Thr Gly Arg Gly Val  Ile Glu Arg Gly Asn  Val Asp Gly 
    1910                 1915                 1920             


Thr Asp  Arg Met Ile Leu Val  His Gln Leu Ser His  Pro Trp Gly 
    1925                 1930                 1935             


Ile Ala  Val His Asp Ser Phe  Leu Tyr Tyr Thr Asp  Glu Gln Tyr 
    1940                 1945                 1950             


Glu Val  Ile Glu Arg Val Asp  Lys Ala Thr Gly Ala  Asn Lys Ile 
    1955                 1960                 1965             


Val Leu  Arg Asp Asn Val Pro  Asn Leu Arg Gly Leu  Gln Val Tyr 
    1970                 1975                 1980             


His Arg  Arg Asn Ala Ala Glu  Ser Ser Asn Gly Cys  Ser Asn Asn 
    1985                 1990                 1995             


Met Asn  Ala Cys Gln Gln Ile  Cys Leu Pro Val Pro  Gly Gly Leu 
    2000                 2005                 2010             


Phe Ser  Cys Ala Cys Ala Thr  Gly Phe Lys Leu Asn  Pro Asp Asn 
    2015                 2020                 2025             


Arg Ser  Cys Ser Pro Tyr Asn  Ser Phe Ile Val Val  Ser Met Leu 
    2030                 2035                 2040             


Ser Ala  Ile Arg Gly Phe Ser  Leu Glu Leu Ser Asp  His Ser Glu 
    2045                 2050                 2055             


Thr Met  Val Pro Val Ala Gly  Gln Gly Arg Asn Ala  Leu His Val 
    2060                 2065                 2070             


Asp Val  Asp Val Ser Ser Gly  Phe Ile Tyr Trp Cys  Asp Phe Ser 
    2075                 2080                 2085             


Ser Ser  Val Ala Ser Asp Asn  Ala Ile Arg Arg Ile  Lys Pro Asp 
    2090                 2095                 2100             


Gly Ser  Ser Leu Met Asn Ile  Val Thr His Gly Ile  Gly Glu Asn 
    2105                 2110                 2115             


Gly Val  Arg Gly Ile Ala Val  Asp Trp Val Ala Gly  Asn Leu Tyr 
    2120                 2125                 2130             


Phe Thr  Asn Ala Phe Val Ser  Glu Thr Leu Ile Glu  Val Leu Arg 
    2135                 2140                 2145             


Ile Asn  Thr Thr Tyr Arg Arg  Val Leu Leu Lys Val  Thr Val Asp 
    2150                 2155                 2160             


Met Pro  Arg His Ile Val Val  Asp Pro Lys Asn Arg  Tyr Leu Phe 
    2165                 2170                 2175             


Trp Ala  Asp Tyr Gly Gln Arg  Pro Lys Ile Glu Arg  Ser Phe Leu 
    2180                 2185                 2190             


Asp Cys  Thr Asn Arg Thr Val  Leu Val Ser Glu Gly  Ile Val Thr 
    2195                 2200                 2205             


Pro Arg  Gly Leu Ala Val Asp  Arg Ser Asp Gly Tyr  Val Tyr Trp 
    2210                 2215                 2220             


Val Asp  Asp Ser Leu Asp Ile  Ile Ala Arg Ile Arg  Ile Asn Gly 
    2225                 2230                 2235             


Glu Asn  Ser Glu Val Ile Arg  Tyr Gly Ser Arg Tyr  Pro Thr Pro 
    2240                 2245                 2250             


Tyr Gly  Ile Thr Val Phe Glu  Asn Ser Ile Ile Trp  Val Asp Arg 
    2255                 2260                 2265             


Asn Leu  Lys Lys Ile Phe Gln  Ala Ser Lys Glu Pro  Glu Asn Thr 
    2270                 2275                 2280             


Glu Pro  Pro Thr Val Ile Arg  Asp Asn Ile Asn Trp  Leu Arg Asp 
    2285                 2290                 2295             


Val Thr  Ile Phe Asp Lys Gln  Val Gln Pro Arg Ser  Pro Ala Glu 
    2300                 2305                 2310             


Val Asn  Asn Asn Pro Cys Leu  Glu Asn Asn Gly Gly  Cys Ser His 
    2315                 2320                 2325             


Leu Cys  Phe Ala Leu Pro Gly  Leu His Thr Pro Lys  Cys Asp Cys 
    2330                 2335                 2340             


Ala Phe  Gly Thr Leu Gln Ser  Asp Gly Lys Asn Cys  Ala Ile Ser 
    2345                 2350                 2355             


Thr Glu  Asn Phe Leu Ile Phe  Ala Leu Ser Asn Ser  Leu Arg Ser 
    2360                 2365                 2370             


Leu His  Leu Asp Pro Glu Asn  His Ser Pro Pro Phe  Gln Thr Ile 
    2375                 2380                 2385             


Asn Val  Glu Arg Thr Val Met  Ser Leu Asp Tyr Asp  Ser Val Ser 
    2390                 2395                 2400             


Asp Arg  Ile Tyr Phe Thr Gln  Asn Leu Ala Ser Gly  Val Gly Gln 
    2405                 2410                 2415             


Ile Ser  Tyr Ala Thr Leu Ser  Ser Gly Ile His Thr  Pro Thr Val 
    2420                 2425                 2430             


Ile Ala  Ser Gly Ile Gly Thr  Ala Asp Gly Ile Ala  Phe Asp Trp 
    2435                 2440                 2445             


Ile Thr  Arg Arg Ile Tyr Tyr  Ser Asp Tyr Leu Asn  Gln Met Ile 
    2450                 2455                 2460             


Asn Ser  Met Ala Glu Asp Gly  Ser Asn Arg Thr Val  Ile Ala Arg 
    2465                 2470                 2475             


Val Pro  Lys Pro Arg Ala Ile  Val Leu Asp Pro Cys  Gln Gly Tyr 
    2480                 2485                 2490             


Leu Tyr  Trp Ala Asp Trp Asp  Thr His Ala Lys Ile  Glu Arg Ala 
    2495                 2500                 2505             


Thr Leu  Gly Gly Asn Phe Arg  
    2510                 2515 


<210>  13
<211>  3623
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Met Asn Met Ser Leu Pro Phe Leu Trp Ser Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ile Phe Ala Glu Val Asn Gly Glu Ala Gly Glu Leu Glu Leu Gln Arg 
            20                  25                  30          


Gln Lys Arg Ser Ile Asn Leu Gln Gln Pro Arg Met Ala Thr Glu Arg 
        35                  40                  45              


Gly Asn Leu Val Phe Leu Thr Gly Ser Ala Gln Asn Ile Glu Phe Arg 
    50                  55                  60                  


Thr Gly Ser Leu Gly Lys Ile Lys Leu Asn Asp Glu Asp Leu Ser Glu 
65                  70                  75                  80  


Cys Leu His Gln Ile Gln Lys Asn Lys Glu Asp Ile Ile Glu Leu Lys 
                85                  90                  95      


Gly Ser Ala Ile Gly Leu Pro Gln Asn Ile Ser Ser Gln Ile Tyr Gln 
            100                 105                 110         


Leu Asn Ser Lys Leu Val Asp Leu Glu Arg Lys Phe Gln Gly Leu Gln 
        115                 120                 125             


Gln Thr Val Asp Lys Lys Val Cys Ser Ser Asn Pro Cys Gln Asn Gly 
    130                 135                 140                 


Gly Thr Cys Leu Asn Leu His Asp Ser Phe Phe Cys Ile Cys Pro Pro 
145                 150                 155                 160 


Gln Trp Lys Gly Pro Leu Cys Ser Ala Asp Val Asn Glu Cys Glu Ile 
                165                 170                 175     


Tyr Ser Gly Thr Pro Leu Ser Cys Gln Asn Gly Gly Thr Cys Val Asn 
            180                 185                 190         


Thr Met Gly Ser Tyr Ser Cys His Cys Pro Pro Glu Thr Tyr Gly Pro 
        195                 200                 205             


Gln Cys Ala Ser Lys Tyr Asp Asp Cys Glu Gly Gly Ser Val Ala Arg 
    210                 215                 220                 


Cys Val His Gly Ile Cys Glu Asp Leu Met Arg Glu Gln Ala Gly Glu 
225                 230                 235                 240 


Pro Lys Tyr Ser Cys Val Cys Asp Ala Gly Trp Met Phe Ser Pro Asn 
                245                 250                 255     


Ser Pro Ala Cys Thr Leu Asp Arg Asp Glu Cys Ser Phe Gln Pro Gly 
            260                 265                 270         


Pro Cys Ser Thr Leu Val Gln Cys Phe Asn Thr Gln Gly Ser Phe Tyr 
        275                 280                 285             


Cys Gly Ala Cys Pro Thr Gly Trp Gln Gly Asn Gly Tyr Ile Cys Glu 
    290                 295                 300                 


Asp Ile Asn Glu Cys Glu Ile Asn Asn Gly Gly Cys Ser Val Ala Pro 
305                 310                 315                 320 


Pro Val Glu Cys Val Asn Thr Pro Gly Ser Ser His Cys Gln Ala Cys 
                325                 330                 335     


Pro Pro Gly Tyr Gln Gly Asp Gly Arg Val Cys Thr Leu Thr Asp Ile 
            340                 345                 350         


Cys Ser Val Ser Asn Gly Gly Cys His Pro Asp Ala Ser Cys Ser Ser 
        355                 360                 365             


Thr Leu Gly Ser Leu Pro Leu Cys Thr Cys Leu Pro Gly Tyr Thr Gly 
    370                 375                 380                 


Asn Gly Tyr Gly Pro Asn Gly Cys Val Gln Leu Ser Asn Ile Cys Leu 
385                 390                 395                 400 


Ser His Pro Cys Leu Asn Gly Gln Cys Ile Asp Thr Val Ser Gly Tyr 
                405                 410                 415     


Phe Cys Lys Cys Asp Ser Gly Trp Thr Gly Val Asn Cys Thr Glu Asn 
            420                 425                 430         


Ile Asn Glu Cys Leu Ser Asn Pro Cys Leu Asn Gly Gly Thr Cys Val 
        435                 440                 445             


Asp Gly Val Asp Ser Phe Ser Cys Glu Cys Thr Arg Leu Trp Thr Gly 
    450                 455                 460                 


Ala Leu Cys Gln Val Pro Gln Gln Val Cys Gly Glu Ser Leu Ser Gly 
465                 470                 475                 480 


Ile Asn Gly Ser Phe Ser Tyr Arg Ser Pro Asp Val Gly Tyr Val His 
                485                 490                 495     


Asp Val Asn Cys Phe Trp Val Ile Lys Thr Glu Met Gly Lys Val Leu 
            500                 505                 510         


Arg Ile Thr Phe Thr Phe Phe Arg Leu Glu Ser Met Asp Asn Cys Pro 
        515                 520                 525             


His Glu Phe Leu Gln Val Tyr Asp Gly Asp Ser Ser Ser Ala Phe Gln 
    530                 535                 540                 


Leu Gly Arg Phe Cys Gly Ser Ser Leu Pro His Glu Leu Leu Ser Ser 
545                 550                 555                 560 


Asp Asn Ala Leu Tyr Phe His Leu Tyr Ser Glu His Leu Arg Asn Gly 
                565                 570                 575     


Arg Gly Phe Thr Val Arg Trp Glu Thr Gln Gln Pro Glu Cys Gly Gly 
            580                 585                 590         


Ile Leu Thr Gly Pro Tyr Gly Ser Ile Lys Ser Pro Gly Tyr Pro Gly 
        595                 600                 605             


Asn Tyr Pro Pro Gly Arg Asp Cys Val Trp Ile Val Val Thr Ser Pro 
    610                 615                 620                 


Asp Leu Leu Val Thr Phe Thr Phe Gly Thr Leu Ser Leu Glu His His 
625                 630                 635                 640 


Asp Asp Cys Asn Lys Asp Tyr Leu Glu Ile Arg Asp Gly Pro Leu Tyr 
                645                 650                 655     


Gln Asp Pro Leu Leu Gly Lys Phe Cys Thr Thr Phe Ser Val Pro Pro 
            660                 665                 670         


Leu Gln Thr Thr Gly Pro Phe Ala Arg Ile His Phe His Ser Asp Ser 
        675                 680                 685             


Gln Ile Ser Asp Gln Gly Phe His Ile Thr Tyr Leu Thr Ser Pro Ser 
    690                 695                 700                 


Asp Leu Arg Cys Gly Gly Asn Tyr Thr Asp Pro Glu Gly Glu Leu Phe 
705                 710                 715                 720 


Leu Pro Glu Leu Ser Gly Pro Phe Thr His Thr Arg Gln Cys Val Tyr 
                725                 730                 735     


Met Met Lys Gln Pro Gln Gly Glu Gln Ile Gln Ile Asn Phe Thr His 
            740                 745                 750         


Val Glu Leu Gln Cys Gln Ser Asp Ser Ser Gln Asn Tyr Ile Glu Val 
        755                 760                 765             


Arg Asp Gly Glu Thr Leu Leu Gly Lys Val Cys Gly Asn Gly Thr Ile 
    770                 775                 780                 


Ser His Ile Lys Ser Ile Thr Asn Ser Val Trp Ile Arg Phe Lys Ile 
785                 790                 795                 800 


Asp Ala Ser Val Glu Lys Ala Ser Phe Arg Ala Val Tyr Gln Val Ala 
                805                 810                 815     


Cys Gly Asp Glu Leu Thr Gly Glu Gly Val Ile Arg Ser Pro Phe Phe 
            820                 825                 830         


Pro Asn Val Tyr Pro Gly Glu Arg Thr Cys Arg Trp Thr Ile His Gln 
        835                 840                 845             


Pro Gln Ser Gln Val Ile Leu Leu Asn Phe Thr Val Phe Glu Ile Gly 
    850                 855                 860                 


Ser Ser Ala His Cys Glu Thr Asp Tyr Val Glu Ile Gly Ser Ser Ser 
865                 870                 875                 880 


Ile Leu Gly Ser Pro Glu Asn Lys Lys Tyr Cys Gly Thr Asp Ile Pro 
                885                 890                 895     


Ser Phe Ile Thr Ser Val Tyr Asn Phe Leu Tyr Val Thr Phe Val Lys 
            900                 905                 910         


Ser Ser Ser Thr Glu Asn His Gly Phe Met Ala Lys Phe Ser Ala Glu 
        915                 920                 925             


Asp Leu Ala Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln 
    930                 935                 940                 


Ser Pro Gly His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp 
945                 950                 955                 960 


His Ile Leu Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr 
                965                 970                 975     


Phe His Leu Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val 
            980                 985                 990         


Tyr Asp Thr Asp Ser Glu Thr Ser  Leu Gly Arg Tyr Cys  Gly Lys Ser 
        995                 1000                 1005             


Ile Pro  Pro Ser Leu Thr Ser  Ser Gly Asn Ser Leu  Met Leu Val 
    1010                 1015                 1020             


Phe Val  Thr Asp Ser Asp Leu  Ala Tyr Glu Gly Phe  Leu Ile Asn 
    1025                 1030                 1035             


Tyr Glu  Ala Ile Ser Ala Ala  Thr Ala Cys Leu Gln  Asp Tyr Thr 
    1040                 1045                 1050             


Asp Asp  Leu Gly Thr Phe Thr  Ser Pro Asn Phe Pro  Asn Asn Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Trp Glu Cys Ile  Tyr Arg Ile Thr Val  Arg Thr Gly 
    1070                 1075                 1080             


Gln Leu  Ile Ala Val His Phe  Thr Asn Phe Ser Leu  Glu Glu Ala 
    1085                 1090                 1095             


Ile Gly  Asn Tyr Tyr Thr Asp  Phe Leu Glu Ile Arg  Asp Gly Gly 
    1100                 1105                 1110             


Tyr Glu  Lys Ser Pro Leu Leu  Gly Ile Phe Tyr Gly  Ser Asn Leu 
    1115                 1120                 1125             


Pro Pro  Thr Ile Ile Ser His  Ser Asn Lys Leu Trp  Leu Lys Phe 
    1130                 1135                 1140             


Lys Ser  Asp Gln Ile Asp Thr  Arg Ser Gly Phe Ser  Ala Tyr Trp 
    1145                 1150                 1155             


Asp Gly  Ser Ser Thr Gly Cys  Gly Gly Asn Leu Thr  Thr Ser Ser 
    1160                 1165                 1170             


Gly Thr  Phe Ile Ser Pro Asn  Tyr Pro Met Pro Tyr  Tyr His Ser 
    1175                 1180                 1185             


Ser Glu  Cys Tyr Trp Trp Leu  Lys Ser Ser His Gly  Ser Ala Phe 
    1190                 1195                 1200             


Glu Leu  Glu Phe Lys Asp Phe  His Leu Glu His His  Pro Asn Cys 
    1205                 1210                 1215             


Thr Leu  Asp Tyr Leu Ala Val  Tyr Asp Gly Pro Ser  Ser Asn Ser 
    1220                 1225                 1230             


His Leu  Leu Thr Gln Leu Cys  Gly Asp Glu Lys Pro  Pro Leu Ile 
    1235                 1240                 1245             


Arg Ser  Ser Gly Asp Ser Met  Phe Ile Lys Leu Arg  Thr Asp Glu 
    1250                 1255                 1260             


Gly Gln  Gln Gly Arg Gly Phe  Lys Ala Glu Tyr Arg  Gln Thr Cys 
    1265                 1270                 1275             


Glu Asn  Val Val Ile Val Asn  Gln Thr Tyr Gly Ile  Leu Glu Ser 
    1280                 1285                 1290             


Ile Gly  Tyr Pro Asn Pro Tyr  Ser Glu Asn Gln His  Cys Asn Trp 
    1295                 1300                 1305             


Thr Ile  Arg Ala Thr Thr Gly  Asn Thr Val Asn Tyr  Thr Phe Leu 
    1310                 1315                 1320             


Ala Phe  Asp Leu Glu His His  Ile Asn Cys Ser Thr  Asp Tyr Leu 
    1325                 1330                 1335             


Glu Leu  Tyr Asp Gly Pro Arg  Gln Met Gly Arg Tyr  Cys Gly Val 
    1340                 1345                 1350             


Asp Leu  Pro Pro Pro Gly Ser  Thr Thr Ser Ser Lys  Leu Gln Val 
    1355                 1360                 1365             


Leu Leu  Leu Thr Asp Gly Val  Gly Arg Arg Glu Lys  Gly Phe Gln 
    1370                 1375                 1380             


Met Gln  Trp Phe Val Tyr Gly  Cys Gly Gly Glu Leu  Ser Gly Ala 
    1385                 1390                 1395             


Thr Gly  Ser Phe Ser Ser Pro  Gly Phe Pro Asn Arg  Tyr Pro Pro 
    1400                 1405                 1410             


Asn Lys  Glu Cys Ile Trp Tyr  Ile Arg Thr Asp Pro  Gly Ser Ser 
    1415                 1420                 1425             


Ile Gln  Leu Thr Ile His Asp  Phe Asp Val Glu Tyr  His Ser Arg 
    1430                 1435                 1440             


Cys Asn  Phe Asp Val Leu Glu  Ile Tyr Gly Gly Pro  Asp Phe His 
    1445                 1450                 1455             


Ser Pro  Arg Ile Ala Gln Leu  Cys Thr Gln Arg Ser  Pro Glu Asn 
    1460                 1465                 1470             


Pro Met  Gln Val Ser Ser Thr  Gly Asn Glu Leu Ala  Ile Arg Phe 
    1475                 1480                 1485             


Lys Thr  Asp Leu Ser Ile Asn  Gly Arg Gly Phe Asn  Ala Ser Trp 
    1490                 1495                 1500             


Gln Ala  Val Thr Gly Gly Cys  Gly Gly Ile Phe Gln  Ala Pro Ser 
    1505                 1510                 1515             


Gly Glu  Ile His Ser Pro Asn  Tyr Pro Ser Pro Tyr  Arg Ser Asn 
    1520                 1525                 1530             


Thr Asp  Cys Ser Trp Val Ile  Arg Val Asp Arg Asn  His Arg Val 
    1535                 1540                 1545             


Leu Leu  Asn Phe Thr Asp Phe  Asp Leu Glu Pro Gln  Asp Ser Cys 
    1550                 1555                 1560             


Ile Met  Ala Tyr Asp Gly Leu  Ser Ser Thr Met Ser  Arg Leu Ala 
    1565                 1570                 1575             


Arg Thr  Cys Gly Arg Glu Gln  Leu Ala Asn Pro Ile  Val Ser Ser 
    1580                 1585                 1590             


Gly Asn  Ser Leu Phe Leu Arg  Phe Gln Ser Gly Pro  Ser Arg Gln 
    1595                 1600                 1605             


Asn Arg  Gly Phe Arg Ala Gln  Phe Arg Gln Ala Cys  Gly Gly His 
    1610                 1615                 1620             


Ile Leu  Thr Ser Ser Phe Asp  Thr Val Ser Ser Pro  Arg Phe Pro 
    1625                 1630                 1635             


Ala Asn  Tyr Pro Asn Asn Gln  Asn Cys Ser Trp Ile  Ile Gln Ala 
    1640                 1645                 1650             


Gln Pro  Pro Leu Asn His Ile  Thr Leu Ser Phe Thr  His Phe Glu 
    1655                 1660                 1665             


Leu Glu  Arg Ser Thr Thr Cys  Ala Arg Asp Phe Val  Glu Ile Leu 
    1670                 1675                 1680             


Asp Gly  Gly His Glu Asp Ala  Pro Leu Arg Gly Arg  Tyr Cys Gly 
    1685                 1690                 1695             


Thr Asp  Met Pro His Pro Ile  Thr Ser Phe Ser Ser  Ala Leu Thr 
    1700                 1705                 1710             


Leu Arg  Phe Val Ser Asp Ser  Ser Ile Ser Ala Gly  Gly Phe His 
    1715                 1720                 1725             


Thr Thr  Val Thr Ala Ser Val  Ser Ala Cys Gly Gly  Thr Phe Tyr 
    1730                 1735                 1740             


Met Ala  Glu Gly Ile Phe Asn  Ser Pro Gly Tyr Pro  Asp Ile Tyr 
    1745                 1750                 1755             


Pro Pro  Asn Val Glu Cys Val  Trp Asn Ile Val Ser  Ser Pro Gly 
    1760                 1765                 1770             


Asn Arg  Leu Gln Leu Ser Phe  Ile Ser Phe Gln Leu  Glu Asp Ser 
    1775                 1780                 1785             


Gln Asp  Cys Ser Arg Asp Phe  Val Glu Ile Arg Glu  Gly Asn Ala 
    1790                 1795                 1800             


Thr Gly  His Leu Val Gly Arg  Tyr Cys Gly Asn Ser  Phe Pro Leu 
    1805                 1810                 1815             


Asn Tyr  Ser Ser Ile Val Gly  His Thr Leu Trp Val  Arg Phe Ile 
    1820                 1825                 1830             


Ser Asp  Gly Ser Gly Ser Gly  Thr Gly Phe Gln Ala  Thr Phe Met 
    1835                 1840                 1845             


Lys Ile  Phe Gly Asn Asp Asn  Ile Val Gly Thr His  Gly Lys Val 
    1850                 1855                 1860             


Ala Ser  Pro Phe Trp Pro Glu  Asn Tyr Pro His Asn  Ser Asn Tyr 
    1865                 1870                 1875             


Gln Trp  Thr Val Asn Val Asn  Ala Ser His Val Val  His Gly Arg 
    1880                 1885                 1890             


Ile Leu  Glu Met Asp Ile Glu  Glu Ile Gln Asn Cys  Tyr Tyr Asp 
    1895                 1900                 1905             


Lys Leu  Arg Ile Tyr Asp Gly  Pro Ser Ile His Ala  Arg Leu Ile 
    1910                 1915                 1920             


Gly Ala  Tyr Cys Gly Thr Gln  Thr Glu Ser Phe Ser  Ser Thr Gly 
    1925                 1930                 1935             


Asn Ser  Leu Thr Phe His Phe  Tyr Ser Asp Ser Ser  Ile Ser Gly 
    1940                 1945                 1950             


Lys Gly  Phe Leu Leu Glu Trp  Phe Ala Val Asp Ala  Pro Asp Gly 
    1955                 1960                 1965             


Val Leu  Pro Thr Ile Ala Pro  Gly Ala Cys Gly Gly  Phe Leu Arg 
    1970                 1975                 1980             


Thr Gly  Asp Ala Pro Val Phe  Leu Phe Ser Pro Gly  Trp Pro Asp 
    1985                 1990                 1995             


Ser Tyr  Ser Asn Arg Val Asp  Cys Thr Trp Leu Ile  Gln Ala Pro 
    2000                 2005                 2010             


Asp Ser  Thr Val Glu Leu Asn  Ile Leu Ser Leu Asp  Ile Glu Ser 
    2015                 2020                 2025             


His Arg  Thr Cys Ala Tyr Asp  Ser Leu Val Ile Arg  Asp Gly Asp 
    2030                 2035                 2040             


Asn Asn  Leu Ala Gln Gln Leu  Ala Val Leu Cys Gly  Arg Glu Ile 
    2045                 2050                 2055             


Pro Gly  Pro Ile Arg Ser Thr  Gly Glu Tyr Met Phe  Ile Arg Phe 
    2060                 2065                 2070             


Thr Ser  Asp Ser Ser Val Thr  Arg Ala Gly Phe Asn  Ala Ser Phe 
    2075                 2080                 2085             


His Lys  Ser Cys Gly Gly Tyr  Leu His Ala Asp Arg  Gly Ile Ile 
    2090                 2095                 2100             


Thr Ser  Pro Lys Tyr Pro Glu  Thr Tyr Pro Ser Asn  Leu Asn Cys 
    2105                 2110                 2115             


Ser Trp  His Val Leu Val Gln  Ser Gly Leu Thr Ile  Ala Val His 
    2120                 2125                 2130             


Phe Glu  Gln Pro Phe Gln Ile  Pro Asn Gly Asp Ser  Ser Cys Asn 
    2135                 2140                 2145             


Gln Gly  Asp Tyr Leu Val Leu  Arg Asn Gly Pro Asp  Ile Cys Ser 
    2150                 2155                 2160             


Pro Pro  Leu Gly Pro Pro Gly  Gly Asn Gly His Phe  Cys Gly Ser 
    2165                 2170                 2175             


His Ala  Ser Ser Thr Leu Phe  Thr Ser Asp Asn Gln  Met Phe Val 
    2180                 2185                 2190             


Gln Phe  Ile Ser Asp His Ser  Asn Glu Gly Gln Gly  Phe Lys Ile 
    2195                 2200                 2205             


Lys Tyr  Glu Ala Lys Ser Leu  Ala Cys Gly Gly Asn  Val Tyr Ile 
    2210                 2215                 2220             


His Asp  Ala Asp Ser Ala Gly  Tyr Val Thr Ser Pro  Asn His Pro 
    2225                 2230                 2235             


His Asn  Tyr Pro Pro His Ala  Asp Cys Ile Trp Ile  Leu Ala Ala 
    2240                 2245                 2250             


Pro Pro  Glu Thr Arg Ile Gln  Leu Gln Phe Glu Asp  Arg Phe Asp 
    2255                 2260                 2265             


Ile Glu  Val Thr Pro Asn Cys  Thr Ser Asn Tyr Leu  Glu Leu Arg 
    2270                 2275                 2280             


Asp Gly  Val Asp Ser Asp Ala  Pro Ile Leu Ser Lys  Phe Cys Gly 
    2285                 2290                 2295             


Thr Ser  Leu Pro Ser Ser Gln  Trp Ser Ser Gly Glu  Val Met Tyr 
    2300                 2305                 2310             


Leu Arg  Phe Arg Ser Asp Asn  Ser Pro Thr His Val  Gly Phe Lys 
    2315                 2320                 2325             


Ala Lys  Tyr Ser Ile Ala Gln  Cys Gly Gly Arg Val  Pro Gly Gln 
    2330                 2335                 2340             


Ser Gly  Val Val Glu Ser Ile  Gly His Pro Thr Leu  Pro Tyr Arg 
    2345                 2350                 2355             


Asp Asn  Leu Phe Cys Glu Trp  His Leu Gln Gly Leu  Ser Gly His 
    2360                 2365                 2370             


Tyr Leu  Thr Ile Ser Phe Glu  Asp Phe Asn Leu Gln  Asn Ser Ser 
    2375                 2380                 2385             


Gly Cys  Glu Lys Asp Phe Val  Glu Ile Trp Asp Asn  His Thr Ser 
    2390                 2395                 2400             


Gly Asn  Ile Leu Gly Arg Tyr  Cys Gly Asn Thr Ile  Pro Asp Ser 
    2405                 2410                 2415             


Ile Asp  Thr Ser Ser Asn Thr  Ala Val Val Arg Phe  Val Thr Asp 
    2420                 2425                 2430             


Gly Ser  Val Thr Ala Ser Gly  Phe Arg Leu Arg Phe  Glu Ser Ser 
    2435                 2440                 2445             


Met Glu  Glu Cys Gly Gly Asp  Leu Gln Gly Ser Ile  Gly Thr Phe 
    2450                 2455                 2460             


Thr Ser  Pro Asn Tyr Pro Asn  Pro Asn Pro His Gly  Arg Ile Cys 
    2465                 2470                 2475             


Glu Trp  Arg Ile Thr Ala Pro  Glu Gly Arg Arg Ile  Thr Leu Met 
    2480                 2485                 2490             


Phe Asn  Asn Leu Arg Leu Ala  Thr His Pro Ser Cys  Asn Asn Glu 
    2495                 2500                 2505             


His Val  Ile Val Phe Asn Gly  Ile Arg Ser Asn Ser  Pro Gln Leu 
    2510                 2515                 2520             


Glu Lys  Leu Cys Ser Ser Val  Asn Val Ser Asn Glu  Ile Lys Ser 
    2525                 2530                 2535             


Ser Gly  Asn Thr Met Lys Val  Ile Phe Phe Thr Asp  Gly Ser Arg 
    2540                 2545                 2550             


Pro Tyr  Gly Gly Phe Thr Ala  Ser Tyr Thr Ser Ser  Glu Asp Ala 
    2555                 2560                 2565             


Val Cys  Gly Gly Ser Leu Pro  Asn Thr Pro Glu Gly  Asn Phe Thr 
    2570                 2575                 2580             


Ser Pro  Gly Tyr Asp Gly Val  Arg Asn Tyr Ser Arg  Asn Leu Asn 
    2585                 2590                 2595             


Cys Glu  Trp Thr Leu Ser Asn  Pro Asn Gln Gly Asn  Ser Ser Ile 
    2600                 2605                 2610             


Ser Ile  His Phe Glu Asp Phe  Tyr Leu Glu Ser His  Gln Asp Cys 
    2615                 2620                 2625             


Gln Phe  Asp Val Leu Glu Phe  Arg Val Gly Asp Ala  Asp Gly Pro 
    2630                 2635                 2640             


Leu Met  Trp Arg Leu Cys Gly  Pro Ser Lys Pro Thr  Leu Pro Leu 
    2645                 2650                 2655             


Val Ile  Pro Tyr Ser Gln Val  Trp Ile His Phe Val  Thr Asn Glu 
    2660                 2665                 2670             


Arg Val  Glu His Ile Gly Phe  His Ala Lys Tyr Ser  Phe Thr Asp 
    2675                 2680                 2685             


Cys Gly  Gly Ile Gln Ile Gly  Asp Ser Gly Val Ile  Thr Ser Pro 
    2690                 2695                 2700             


Asn Tyr  Pro Asn Ala Tyr Asp  Ser Leu Thr His Cys  Ser Ser Leu 
    2705                 2710                 2715             


Leu Glu  Ala Pro Gln Gly His  Thr Ile Thr Leu Thr  Phe Ser Asp 
    2720                 2725                 2730             


Phe Asp  Ile Glu Pro His Thr  Thr Cys Ala Trp Asp  Ser Val Thr 
    2735                 2740                 2745             


Val Arg  Asn Gly Gly Ser Pro  Glu Ser Pro Ile Ile  Gly Gln Tyr 
    2750                 2755                 2760             


Cys Gly  Asn Ser Asn Pro Arg  Thr Ile Gln Ser Gly  Ser Asn Gln 
    2765                 2770                 2775             


Leu Val  Val Thr Phe Asn Ser  Asp His Ser Leu Gln  Gly Gly Gly 
    2780                 2785                 2790             


Phe Tyr  Ala Thr Trp Asn Thr  Gln Thr Leu Gly Cys  Gly Gly Ile 
    2795                 2800                 2805             


Phe His  Ser Asp Asn Gly Thr  Ile Arg Ser Pro His  Trp Pro Gln 
    2810                 2815                 2820             


Asn Phe  Pro Glu Asn Ser Arg  Cys Ser Trp Thr Ala  Ile Thr His 
    2825                 2830                 2835             


Lys Ser  Lys His Leu Glu Ile  Ser Phe Asp Asn Asn  Phe Leu Ile 
    2840                 2845                 2850             


Pro Ser  Gly Asp Gly Gln Cys  Gln Asn Ser Phe Val  Lys Val Trp 
    2855                 2860                 2865             


Ala Gly  Thr Glu Glu Val Asp  Lys Ala Leu Leu Ala  Thr Gly Cys 
    2870                 2875                 2880             


Gly Asn  Val Ala Pro Gly Pro  Val Ile Thr Pro Ser  Asn Thr Phe 
    2885                 2890                 2895             


Thr Ala  Val Phe Gln Ser Gln  Glu Ala Pro Ala Gln  Gly Phe Ser 
    2900                 2905                 2910             


Ala Ser  Phe Val Ser Arg Cys  Gly Ser Asn Phe Thr  Gly Pro Ser 
    2915                 2920                 2925             


Gly Tyr  Ile Ile Ser Pro Asn  Tyr Pro Lys Gln Tyr  Asp Asn Asn 
    2930                 2935                 2940             


Met Asn  Cys Thr Tyr Val Ile  Glu Ala Asn Pro Leu  Ser Val Val 
    2945                 2950                 2955             


Leu Leu  Thr Phe Val Ser Phe  His Leu Glu Ala Arg  Ser Ala Val 
    2960                 2965                 2970             


Thr Gly  Ser Cys Val Asn Asp  Gly Val His Ile Ile  Arg Gly Tyr 
    2975                 2980                 2985             


Ser Val  Met Ser Thr Pro Phe  Ala Thr Val Cys Gly  Asp Glu Met 
    2990                 2995                 3000             


Pro Ala  Pro Leu Thr Ile Ala  Gly Pro Val Leu Leu  Asn Phe Tyr 
    3005                 3010                 3015             


Ser Asn  Glu Gln Ile Thr Asp  Phe Gly Phe Lys Phe  Ser Tyr Arg 
    3020                 3025                 3030             


Ile Ile  Ser Cys Gly Gly Val  Phe Asn Phe Ser Ser  Gly Ile Ile 
    3035                 3040                 3045             


Thr Ser  Pro Ala Tyr Ser Tyr  Ala Asp Tyr Pro Asn  Asp Met His 
    3050                 3055                 3060             


Cys Leu  Tyr Thr Ile Thr Val  Ser Asp Asp Lys Val  Ile Glu Leu 
    3065                 3070                 3075             


Lys Phe  Ser Asp Phe Asp Val  Val Pro Ser Thr Ser  Cys Ser His 
    3080                 3085                 3090             


Asp Tyr  Leu Ala Ile Tyr Asp  Gly Ala Asn Thr Ser  Asp Pro Leu 
    3095                 3100                 3105             


Leu Gly  Lys Phe Cys Gly Ser  Lys Arg Pro Pro Asn  Val Lys Ser 
    3110                 3115                 3120             


Ser Asn  Asn Ser Met Leu Leu  Val Phe Lys Thr Asp  Ser Phe Gln 
    3125                 3130                 3135             


Thr Ala  Lys Gly Trp Lys Met  Ser Phe Arg Gln Thr  Leu Gly Pro 
    3140                 3145                 3150             


Gln Gln  Gly Cys Gly Gly Tyr  Leu Thr Gly Ser Asn  Asn Thr Phe 
    3155                 3160                 3165             


Ala Ser  Pro Asp Ser Asp Ser  Asn Gly Met Tyr Asp  Lys Asn Leu 
    3170                 3175                 3180             


Asn Cys  Val Trp Ile Ile Ile  Ala Pro Val Asn Lys  Val Ile His 
    3185                 3190                 3195             


Leu Thr  Phe Asn Thr Phe Ala  Leu Glu Ala Ala Ser  Thr Arg Gln 
    3200                 3205                 3210             


Arg Cys  Leu Tyr Asp Tyr Val  Lys Leu Tyr Asp Gly  Asp Ser Glu 
    3215                 3220                 3225             


Asn Ala  Asn Leu Ala Gly Thr  Phe Cys Gly Ser Thr  Val Pro Ala 
    3230                 3235                 3240             


Pro Phe  Ile Ser Ser Gly Asn  Phe Leu Thr Val Gln  Phe Ile Ser 
    3245                 3250                 3255             


Asp Leu  Thr Leu Glu Arg Glu  Gly Phe Asn Ala Thr  Tyr Thr Ile 
    3260                 3265                 3270             


Met Asp  Met Pro Cys Gly Gly  Thr Tyr Asn Ala Thr  Trp Thr Pro 
    3275                 3280                 3285             


Gln Asn  Ile Ser Ser Pro Asn  Ser Ser Asp Pro Asp  Val Pro Phe 
    3290                 3295                 3300             


Ser Ile  Cys Thr Trp Val Ile  Asp Ser Pro Pro His  Gln Gln Val 
    3305                 3310                 3315             


Lys Ile  Thr Val Trp Ala Leu  Gln Leu Thr Ser Gln  Asp Cys Thr 
    3320                 3325                 3330             


Gln Asn  Tyr Leu Gln Leu Gln  Asp Ser Pro Gln Gly  His Gly Asn 
    3335                 3340                 3345             


Ser Arg  Phe Gln Phe Cys Gly  Arg Asn Ala Ser Ala  Val Pro Val 
    3350                 3355                 3360             


Phe Tyr  Ser Ser Met Ser Thr  Ala Met Val Ile Phe  Lys Ser Gly 
    3365                 3370                 3375             


Val Val  Asn Arg Asn Ser Arg  Met Ser Phe Thr Tyr  Gln Ile Ala 
    3380                 3385                 3390             


Asp Cys  Asn Arg Asp Tyr His  Lys Ala Phe Gly Asn  Leu Arg Ser 
    3395                 3400                 3405             


Pro Gly  Trp Pro Asp Asn Tyr  Asp Asn Asp Lys Asp  Cys Thr Val 
    3410                 3415                 3420             


Thr Leu  Thr Ala Pro Gln Asn  His Thr Ile Ser Leu  Phe Phe His 
    3425                 3430                 3435             


Ser Leu  Gly Ile Glu Asn Ser  Val Glu Cys Arg Asn  Asp Phe Leu 
    3440                 3445                 3450             


Glu Val  Arg Asn Gly Ser Asn  Ser Asn Ser Pro Leu  Leu Gly Lys 
    3455                 3460                 3465             


Tyr Cys  Gly Thr Leu Leu Pro  Asn Pro Val Phe Ser  Gln Asn Asn 
    3470                 3475                 3480             


Glu Leu  Tyr Leu Arg Phe Lys  Ser Asp Ser Val Thr  Ser Asp Arg 
    3485                 3490                 3495             


Gly Tyr  Glu Ile Ile Trp Thr  Ser Ser Pro Ser Gly  Cys Gly Gly 
    3500                 3505                 3510             


Thr Leu  Tyr Gly Asp Arg Gly  Ser Phe Thr Ser Pro  Gly Tyr Pro 
    3515                 3520                 3525             


Gly Thr  Tyr Pro Asn Asn Thr  Tyr Cys Glu Trp Val  Leu Val Ala 
    3530                 3535                 3540             


Pro Ala  Gly Arg Leu Val Thr  Ile Asn Phe Tyr Phe  Ile Ser Ile 
    3545                 3550                 3555             


Asp Asp  Pro Gly Asp Cys Val  Gln Asn Tyr Leu Thr  Leu Tyr Asp 
    3560                 3565                 3570             


Gly Pro  Asn Ala Ser Ser Pro  Ser Ser Gly Pro Tyr  Cys Gly Gly 
    3575                 3580                 3585             


Asp Thr  Ser Ile Ala Pro Phe  Val Ala Ser Ser Asn  Gln Val Phe 
    3590                 3595                 3600             


Ile Lys  Phe His Ala Asp Tyr  Ala Arg Arg Pro Ser  Ala Phe Arg 
    3605                 3610                 3615             


Leu Thr  Trp Asp Ser 
    3620             


<210>  14
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Ser Asn Pro Cys Gln Asn Gly Gly Thr Cys Leu Asn Leu His Asp 
1               5                   10                  15      


Ser Phe Phe Cys Ile Cys Pro Pro Gln Trp Lys Gly Pro Leu Cys Ser 
            20                  25                  30          


Ala Asp Val Asn Glu Cys Glu Ile Tyr Ser Gly Thr Pro Leu Ser Cys 
        35                  40                  45              


Gln Asn Gly Gly Thr Cys Val Asn Thr Met Gly Ser Tyr Ser Cys His 
    50                  55                  60                  


Cys Pro Pro Glu Thr Tyr Gly Pro Gln Cys Ala Ser Lys Tyr Asp Asp 
65                  70                  75                  80  


Cys Glu Gly Gly Ser Val Ala Arg Cys Val His Gly Ile Cys Glu Asp 
                85                  90                  95      


Leu Met Arg Glu Gln Ala Gly Glu Pro Lys Tyr Ser Cys Val Cys Asp 
            100                 105                 110         


Ala Gly Trp Met Phe Ser Pro Asn Ser Pro Ala Cys Thr Leu Asp Arg 
        115                 120                 125             


Asp Glu Cys Ser Phe Gln Pro Gly Pro Cys Ser Thr Leu Val Gln Cys 
    130                 135                 140                 


Phe Asn Thr Gln Gly Ser Phe Tyr Cys Gly Ala Cys Pro Thr Gly Trp 
145                 150                 155                 160 


Gln Gly Asn Gly Tyr Ile Cys Glu Asp Ile Asn Glu Cys Glu Ile Asn 
                165                 170                 175     


Asn Gly Gly Cys Ser Val Ala Pro Pro Val Glu Cys Val Asn Thr Pro 
            180                 185                 190         


Gly Ser Ser His Cys Gln Ala Cys Pro Pro Gly Tyr Gln Gly Asp Gly 
        195                 200                 205             


Arg Val Cys Thr Leu Thr Asp Ile Cys Ser Val Ser Asn Gly Gly Cys 
    210                 215                 220                 


His Pro Asp Ala Ser Cys Ser Ser Thr Leu Gly Ser Leu Pro Leu Cys 
225                 230                 235                 240 


Thr Cys Leu Pro Gly Tyr Thr Gly Asn Gly Tyr Gly Pro Asn Gly Cys 
                245                 250                 255     


Val Gln Leu Ser Asn Ile Cys Leu Ser His Pro Cys Leu Asn Gly Gln 
            260                 265                 270         


Cys Ile Asp Thr Val Ser Gly Tyr Phe Cys Lys Cys Asp Ser Gly Trp 
        275                 280                 285             


Thr Gly Val Asn Cys Thr Glu Asn Ile Asn Glu Cys Leu Ser Asn Pro 
    290                 295                 300                 


Cys Leu Asn Gly Gly Thr Cys Val Asp Gly Val Asp Ser Phe Ser Cys 
305                 310                 315                 320 


Glu Cys Thr Arg Leu Trp Thr Gly Ala Leu Cys Gln 
                325                 330         


<210>  15
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  15

Cys Gly Glu Ser Leu Ser Gly Ile Asn Gly Ser Phe Ser Tyr Arg Ser 
1               5                   10                  15      


Pro Asp Val Gly Tyr Val His Asp Val Asn Cys Phe Trp Val Ile Lys 
            20                  25                  30          


Thr Glu Met Gly Lys Val Leu Arg Ile Thr Phe Thr Phe Phe Arg Leu 
        35                  40                  45              


Glu Ser Met Asp Asn Cys Pro His Glu Phe Leu Gln Val Tyr Asp Gly 
    50                  55                  60                  


Asp Ser Ser Ser Ala Phe Gln Leu Gly Arg Phe Cys Gly Ser Ser Leu 
65                  70                  75                  80  


Pro His Glu Leu Leu Ser Ser Asp Asn Ala Leu Tyr Phe His Leu Tyr 
                85                  90                  95      


Ser Glu His Leu Arg Asn Gly Arg Gly Phe Thr Val Arg Trp Glu Thr 
            100                 105                 110         


Gln Gln Pro Glu Cys Gly Gly Ile Leu Thr Gly Pro Tyr Gly Ser Ile 
        115                 120                 125             


Lys Ser Pro Gly Tyr Pro Gly Asn Tyr Pro Pro Gly Arg Asp Cys Val 
    130                 135                 140                 


Trp Ile Val Val Thr Ser Pro Asp Leu Leu Val Thr Phe Thr Phe Gly 
145                 150                 155                 160 


Thr Leu Ser Leu Glu His His Asp Asp Cys Asn Lys Asp Tyr Leu Glu 
                165                 170                 175     


Ile Arg Asp Gly Pro Leu Tyr Gln Asp Pro Leu Leu Gly Lys Phe Cys 
            180                 185                 190         


Thr Thr Phe Ser Val Pro Pro Leu Gln Thr Thr Gly Pro Phe Ala Arg 
        195                 200                 205             


Ile His Phe His Ser Asp Ser Gln Ile Ser Asp Gln Gly Phe His Ile 
    210                 215                 220                 


Thr Tyr Leu Thr Ser Pro Ser Asp Leu Arg Cys Gly Gly Asn Tyr Thr 
225                 230                 235                 240 


Asp Pro Glu Gly Glu Leu Phe Leu Pro Glu Leu Ser Gly Pro Phe Thr 
                245                 250                 255     


His Thr Arg Gln Cys Val Tyr Met Met Lys Gln Pro Gln Gly Glu Gln 
            260                 265                 270         


Ile Gln Ile Asn Phe Thr His Val Glu Leu Gln Cys Gln Ser Asp Ser 
        275                 280                 285             


Ser Gln Asn Tyr Ile Glu Val Arg Asp Gly Glu Thr Leu Leu Gly Lys 
    290                 295                 300                 


Val Cys Gly Asn Gly Thr Ile Ser His Ile Lys Ser Ile Thr Asn Ser 
305                 310                 315                 320 


Val Trp Ile Arg Phe Lys Ile Asp Ala Ser Val Glu Lys Ala Ser Phe 
                325                 330                 335     


Arg Ala Val Tyr Gln Val Ala Cys Gly Asp Glu Leu Thr Gly Glu Gly 
            340                 345                 350         


Val Ile Arg Ser Pro Phe Phe Pro Asn Val Tyr Pro Gly Glu Arg Thr 
        355                 360                 365             


Cys Arg Trp Thr Ile His Gln Pro Gln Ser Gln Val Ile Leu Leu Asn 
    370                 375                 380                 


Phe Thr Val Phe Glu Ile Gly Ser Ser Ala His Cys Glu Thr Asp Tyr 
385                 390                 395                 400 


Val Glu Ile Gly Ser Ser Ser Ile Leu Gly Ser Pro Glu Asn Lys Lys 
                405                 410                 415     


Tyr Cys Gly Thr Asp Ile Pro Ser Phe Ile Thr Ser Val Tyr Asn Phe 
            420                 425                 430         


Leu Tyr Val Thr Phe Val Lys Ser Ser Ser Thr Glu Asn His Gly Phe 
        435                 440                 445             


Met Ala Lys Phe Ser Ala Glu Asp Leu Ala Cys Gly Glu Ile Leu Thr 
    450                 455                 460                 


Glu Ser Thr Gly Thr Ile Gln Ser Pro Gly His Pro Asn Val Tyr Pro 
465                 470                 475                 480 


His Gly Ile Asn Cys Thr Trp His Ile Leu Val Gln Pro Asn His Leu 
                485                 490                 495     


Ile His Leu Met Phe Glu Thr Phe His Leu Glu Phe His Tyr Asn Cys 
            500                 505                 510         


Thr Asn Asp Tyr Leu Glu Val Tyr Asp Thr Asp Ser Glu Thr Ser Leu 
        515                 520                 525             


Gly Arg Tyr Cys Gly Lys Ser Ile Pro Pro Ser Leu Thr Ser Ser Gly 
    530                 535                 540                 


Asn Ser Leu Met Leu Val Phe Val Thr Asp Ser Asp Leu Ala Tyr Glu 
545                 550                 555                 560 


Gly Phe Leu Ile Asn Tyr Glu Ala Ile Ser Ala Ala Thr Ala Cys Leu 
                565                 570                 575     


Gln Asp Tyr Thr Asp Asp Leu Gly Thr Phe Thr Ser Pro Asn Phe Pro 
            580                 585                 590         


Asn Asn Tyr Pro Asn Asn Trp Glu Cys Ile Tyr Arg Ile Thr Val Arg 
        595                 600                 605             


Thr Gly Gln Leu Ile Ala Val His Phe Thr Asn Phe Ser Leu Glu Glu 
    610                 615                 620                 


Ala Ile Gly Asn Tyr Tyr Thr Asp Phe Leu Glu Ile Arg Asp Gly Gly 
625                 630                 635                 640 


Tyr Glu Lys Ser Pro Leu Leu Gly Ile Phe Tyr Gly Ser Asn Leu Pro 
                645                 650                 655     


Pro Thr Ile Ile Ser His Ser Asn Lys Leu Trp Leu Lys Phe Lys Ser 
            660                 665                 670         


Asp Gln Ile Asp Thr Arg Ser Gly Phe Ser Ala Tyr Trp Asp Gly Ser 
        675                 680                 685             


Ser Thr Gly Cys Gly Gly Asn Leu Thr Thr Ser Ser Gly Thr Phe Ile 
    690                 695                 700                 


Ser Pro Asn Tyr Pro Met Pro Tyr Tyr His Ser Ser Glu Cys Tyr Trp 
705                 710                 715                 720 


Trp Leu Lys Ser Ser His Gly Ser Ala Phe Glu Leu Glu Phe Lys Asp 
                725                 730                 735     


Phe His Leu Glu His His Pro Asn Cys Thr Leu Asp Tyr Leu Ala Val 
            740                 745                 750         


Tyr Asp Gly Pro Ser Ser Asn Ser His Leu Leu Thr Gln Leu Cys Gly 
        755                 760                 765             


Asp Glu Lys Pro Pro Leu Ile Arg Ser Ser Gly Asp Ser Met Phe Ile 
    770                 775                 780                 


Lys Leu Arg Thr Asp Glu Gly Gln Gln Gly Arg Gly Phe Lys Ala Glu 
785                 790                 795                 800 


Tyr Arg 
        


<210>  16
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  16

Cys Gly Glu Ile Leu Thr Glu Ser Thr Gly Thr Ile Gln Ser Pro Gly 
1               5                   10                  15      


His Pro Asn Val Tyr Pro His Gly Ile Asn Cys Thr Trp His Ile Leu 
            20                  25                  30          


Val Gln Pro Asn His Leu Ile His Leu Met Phe Glu Thr Phe His Leu 
        35                  40                  45              


Glu Phe His Tyr Asn Cys Thr Asn Asp Tyr Leu Glu Val Tyr Asp Thr 
    50                  55                  60                  


Asp Ser Glu Thr Ser Leu Gly Arg Tyr Cys Gly Lys Ser Ile Pro Pro 
65                  70                  75                  80  


Ser Leu Thr Ser Ser Gly Asn Ser Leu Met Leu Val Phe Val Thr Asp 
                85                  90                  95      


Ser Asp Leu Ala Tyr Glu Gly Phe Leu Ile Asn Tyr Glu Ala Ile Ser 
            100                 105                 110         


Ala Ala Thr Ala Cys Leu Gln Asp Tyr Thr Asp Asp Leu Gly Thr Phe 
        115                 120                 125             


Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp Glu Cys Ile 
    130                 135                 140                 


Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val His Phe Thr 
145                 150                 155                 160 


Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr Asp Phe Leu 
                165                 170                 175     


Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu Gly Ile Phe 
            180                 185                 190         


Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser Asn Lys Leu 
        195                 200                 205             


Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser Gly Phe Ser 
    210                 215                 220                 


Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn Leu Thr Thr 
225                 230                 235                 240 


Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro Tyr Tyr His 
                245                 250                 255     


Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly Ser Ala Phe 
            260                 265                 270         


Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro Asn Cys Thr 
        275                 280                 285             


Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn Ser His Leu 
    290                 295                 300                 


Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile Arg Ser Ser 
305                 310                 315                 320 


Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly Gln Gln Gly 
                325                 330                 335     


Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn Val Val Ile 
            340                 345                 350         


Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr Pro Asn Pro 
        355                 360                 365             


Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala Thr Thr Gly 
    370                 375                 380                 


Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu His His Ile 
385                 390                 395                 400 


Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro Arg Gln Met 
                405                 410                 415     


Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser Thr Thr Ser 
            420                 425                 430         


Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly Arg Arg Glu 
        435                 440                 445             


Lys Gly Phe Gln Met Gln Trp Phe Val 
    450                 455         


<210>  17
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Thr Phe Thr Ser Pro Asn Phe Pro Asn Asn Tyr Pro Asn Asn Trp 
1               5                   10                  15      


Glu Cys Ile Tyr Arg Ile Thr Val Arg Thr Gly Gln Leu Ile Ala Val 
            20                  25                  30          


His Phe Thr Asn Phe Ser Leu Glu Glu Ala Ile Gly Asn Tyr Tyr Thr 
        35                  40                  45              


Asp Phe Leu Glu Ile Arg Asp Gly Gly Tyr Glu Lys Ser Pro Leu Leu 
    50                  55                  60                  


Gly Ile Phe Tyr Gly Ser Asn Leu Pro Pro Thr Ile Ile Ser His Ser 
65                  70                  75                  80  


Asn Lys Leu Trp Leu Lys Phe Lys Ser Asp Gln Ile Asp Thr Arg Ser 
                85                  90                  95      


Gly Phe Ser Ala Tyr Trp Asp Gly Ser Ser Thr Gly Cys Gly Gly Asn 
            100                 105                 110         


Leu Thr Thr Ser Ser Gly Thr Phe Ile Ser Pro Asn Tyr Pro Met Pro 
        115                 120                 125             


Tyr Tyr His Ser Ser Glu Cys Tyr Trp Trp Leu Lys Ser Ser His Gly 
    130                 135                 140                 


Ser Ala Phe Glu Leu Glu Phe Lys Asp Phe His Leu Glu His His Pro 
145                 150                 155                 160 


Asn Cys Thr Leu Asp Tyr Leu Ala Val Tyr Asp Gly Pro Ser Ser Asn 
                165                 170                 175     


Ser His Leu Leu Thr Gln Leu Cys Gly Asp Glu Lys Pro Pro Leu Ile 
            180                 185                 190         


Arg Ser Ser Gly Asp Ser Met Phe Ile Lys Leu Arg Thr Asp Glu Gly 
        195                 200                 205             


Gln Gln Gly Arg Gly Phe Lys Ala Glu Tyr Arg Gln Thr Cys Glu Asn 
    210                 215                 220                 


Val Val Ile Val Asn Gln Thr Tyr Gly Ile Leu Glu Ser Ile Gly Tyr 
225                 230                 235                 240 


Pro Asn Pro Tyr Ser Glu Asn Gln His Cys Asn Trp Thr Ile Arg Ala 
                245                 250                 255     


Thr Thr Gly Asn Thr Val Asn Tyr Thr Phe Leu Ala Phe Asp Leu Glu 
            260                 265                 270         


His His Ile Asn Cys Ser Thr Asp Tyr Leu Glu Leu Tyr Asp Gly Pro 
        275                 280                 285             


Arg Gln Met Gly Arg Tyr Cys Gly Val Asp Leu Pro Pro Pro Gly Ser 
    290                 295                 300                 


Thr Thr Ser Ser Lys Leu Gln Val Leu Leu Leu Thr Asp Gly Val Gly 
305                 310                 315                 320 


Arg Arg Glu Lys Gly Phe Gln Met Gln Trp Phe Val Tyr Gly Cys Gly 
                325                 330                 335     


Gly Glu Leu Ser Gly Ala Thr Gly Ser Phe Ser Ser Pro Gly Phe Pro 
            340                 345                 350         


Asn Arg Tyr Pro Pro Asn Lys Glu Cys Ile Trp Tyr Ile Arg Thr Asp 
        355                 360                 365             


Pro Gly Ser Ser Ile Gln Leu Thr Ile His Asp Phe Asp Val Glu Tyr 
    370                 375                 380                 


His Ser Arg Cys Asn Phe Asp Val Leu Glu Ile Tyr Gly Gly Pro Asp 
385                 390                 395                 400 


Phe His Ser Pro Arg Ile Ala Gln Leu Cys Thr Gln Arg Ser Pro Glu 
                405                 410                 415     


Asn Pro Met Gln Val Ser Ser Thr Gly Asn Glu Leu Ala Ile Arg Phe 
            420                 425                 430         


Lys Thr Asp Leu Ser Ile Asn Gly Arg Gly Phe Asn Ala Ser Trp Gln 
        435                 440                 445             


Ala Val Thr Gly Gly Cys Gly Gly Ile Phe Gln Ala Pro Ser Gly Glu 
    450                 455                 460                 


Ile His Ser Pro Asn Tyr Pro Ser Pro Tyr Arg Ser Asn Thr Asp Cys 
465                 470                 475                 480 


Ser Trp Val Ile Arg Val Asp Arg Asn His Arg Val Leu Leu Asn Phe 
                485                 490                 495     


Thr Asp Phe Asp Leu Glu Pro Gln Asp Ser Cys Ile Met Ala Tyr Asp 
            500                 505                 510         


Gly Leu Ser Ser Thr Met Ser Arg Leu Ala Arg Thr Cys Gly Arg Glu 
        515                 520                 525             


Gln Leu Ala Asn Pro Ile Val Ser Ser Gly Asn Ser Leu Phe Leu Arg 
    530                 535                 540                 


Phe Gln Ser Gly Pro Ser Arg Gln Asn Arg Gly Phe Arg Ala Gln Phe 
545                 550                 555                 560 


Arg Gln Ala Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val 
                565                 570                 575     


Ser Ser Pro Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser 
            580                 585                 590         


Trp Ile Ile Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe 
        595                 600                 605             


Thr His Phe Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val 
    610                 615                 620                 


Glu Ile Leu Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr 
625                 630                 635                 640 


Cys Gly Thr Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu 
                645                 650                 655     


Thr Leu Arg Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His 
            660                 665                 670         


Thr Thr Val Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met 
        675                 680                 685             


Ala Glu Gly Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro 
    690                 695                 700                 


Asn Val Glu Cys Val Trp Asn Ile Val Ser Ser Pro Gly Asn Arg Leu 
705                 710                 715                 720 


Gln Leu Ser Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser 
                725                 730                 735     


Arg Asp Phe Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val 
            740                 745                 750         


Gly Arg Tyr Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val 
        755                 760                 765             


Gly His Thr Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly 
    770                 775                 780                 


Thr Gly Phe Gln Ala Thr Phe 
785                 790     


<210>  18
<211>  828
<212>  PRT
<213>  Homo sapiens

<400>  18

Cys Gly Gly His Ile Leu Thr Ser Ser Phe Asp Thr Val Ser Ser Pro 
1               5                   10                  15      


Arg Phe Pro Ala Asn Tyr Pro Asn Asn Gln Asn Cys Ser Trp Ile Ile 
            20                  25                  30          


Gln Ala Gln Pro Pro Leu Asn His Ile Thr Leu Ser Phe Thr His Phe 
        35                  40                  45              


Glu Leu Glu Arg Ser Thr Thr Cys Ala Arg Asp Phe Val Glu Ile Leu 
    50                  55                  60                  


Asp Gly Gly His Glu Asp Ala Pro Leu Arg Gly Arg Tyr Cys Gly Thr 
65                  70                  75                  80  


Asp Met Pro His Pro Ile Thr Ser Phe Ser Ser Ala Leu Thr Leu Arg 
                85                  90                  95      


Phe Val Ser Asp Ser Ser Ile Ser Ala Gly Gly Phe His Thr Thr Val 
            100                 105                 110         


Thr Ala Ser Val Ser Ala Cys Gly Gly Thr Phe Tyr Met Ala Glu Gly 
        115                 120                 125             


Ile Phe Asn Ser Pro Gly Tyr Pro Asp Ile Tyr Pro Pro Asn Val Glu 
    130                 135                 140                 


Cys Val Trp Asn Ile Val Ser Ser Pro Gly Asn Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Phe Ile Ser Phe Gln Leu Glu Asp Ser Gln Asp Cys Ser Arg Asp Phe 
                165                 170                 175     


Val Glu Ile Arg Glu Gly Asn Ala Thr Gly His Leu Val Gly Arg Tyr 
            180                 185                 190         


Cys Gly Asn Ser Phe Pro Leu Asn Tyr Ser Ser Ile Val Gly His Thr 
        195                 200                 205             


Leu Trp Val Arg Phe Ile Ser Asp Gly Ser Gly Ser Gly Thr Gly Phe 
    210                 215                 220                 


Gln Ala Thr Phe Met Lys Ile Phe Gly Asn Asp Asn Ile Val Gly Thr 
225                 230                 235                 240 


His Gly Lys Val Ala Ser Pro Phe Trp Pro Glu Asn Tyr Pro His Asn 
                245                 250                 255     


Ser Asn Tyr Gln Trp Thr Val Asn Val Asn Ala Ser His Val Val His 
            260                 265                 270         


Gly Arg Ile Leu Glu Met Asp Ile Glu Glu Ile Gln Asn Cys Tyr Tyr 
        275                 280                 285             


Asp Lys Leu Arg Ile Tyr Asp Gly Pro Ser Ile His Ala Arg Leu Ile 
    290                 295                 300                 


Gly Ala Tyr Cys Gly Thr Gln Thr Glu Ser Phe Ser Ser Thr Gly Asn 
305                 310                 315                 320 


Ser Leu Thr Phe His Phe Tyr Ser Asp Ser Ser Ile Ser Gly Lys Gly 
                325                 330                 335     


Phe Leu Leu Glu Trp Phe Ala Val Asp Ala Pro Asp Gly Val Leu Pro 
            340                 345                 350         


Thr Ile Ala Pro Gly Ala Cys Gly Gly Phe Leu Arg Thr Gly Asp Ala 
        355                 360                 365             


Pro Val Phe Leu Phe Ser Pro Gly Trp Pro Asp Ser Tyr Ser Asn Arg 
    370                 375                 380                 


Val Asp Cys Thr Trp Leu Ile Gln Ala Pro Asp Ser Thr Val Glu Leu 
385                 390                 395                 400 


Asn Ile Leu Ser Leu Asp Ile Glu Ser His Arg Thr Cys Ala Tyr Asp 
                405                 410                 415     


Ser Leu Val Ile Arg Asp Gly Asp Asn Asn Leu Ala Gln Gln Leu Ala 
            420                 425                 430         


Val Leu Cys Gly Arg Glu Ile Pro Gly Pro Ile Arg Ser Thr Gly Glu 
        435                 440                 445             


Tyr Met Phe Ile Arg Phe Thr Ser Asp Ser Ser Val Thr Arg Ala Gly 
    450                 455                 460                 


Phe Asn Ala Ser Phe His Lys Ser Cys Gly Gly Tyr Leu His Ala Asp 
465                 470                 475                 480 


Arg Gly Ile Ile Thr Ser Pro Lys Tyr Pro Glu Thr Tyr Pro Ser Asn 
                485                 490                 495     


Leu Asn Cys Ser Trp His Val Leu Val Gln Ser Gly Leu Thr Ile Ala 
            500                 505                 510         


Val His Phe Glu Gln Pro Phe Gln Ile Pro Asn Gly Asp Ser Ser Cys 
        515                 520                 525             


Asn Gln Gly Asp Tyr Leu Val Leu Arg Asn Gly Pro Asp Ile Cys Ser 
    530                 535                 540                 


Pro Pro Leu Gly Pro Pro Gly Gly Asn Gly His Phe Cys Gly Ser His 
545                 550                 555                 560 


Ala Ser Ser Thr Leu Phe Thr Ser Asp Asn Gln Met Phe Val Gln Phe 
                565                 570                 575     


Ile Ser Asp His Ser Asn Glu Gly Gln Gly Phe Lys Ile Lys Tyr Glu 
            580                 585                 590         


Ala Lys Ser Leu Ala Cys Gly Gly Asn Val Tyr Ile His Asp Ala Asp 
        595                 600                 605             


Ser Ala Gly Tyr Val Thr Ser Pro Asn His Pro His Asn Tyr Pro Pro 
    610                 615                 620                 


His Ala Asp Cys Ile Trp Ile Leu Ala Ala Pro Pro Glu Thr Arg Ile 
625                 630                 635                 640 


Gln Leu Gln Phe Glu Asp Arg Phe Asp Ile Glu Val Thr Pro Asn Cys 
                645                 650                 655     


Thr Ser Asn Tyr Leu Glu Leu Arg Asp Gly Val Asp Ser Asp Ala Pro 
            660                 665                 670         


Ile Leu Ser Lys Phe Cys Gly Thr Ser Leu Pro Ser Ser Gln Trp Ser 
        675                 680                 685             


Ser Gly Glu Val Met Tyr Leu Arg Phe Arg Ser Asp Asn Ser Pro Thr 
    690                 695                 700                 


His Val Gly Phe Lys Ala Lys Tyr Ser Ile Ala Gln Cys Gly Gly Arg 
705                 710                 715                 720 


Val Pro Gly Gln Ser Gly Val Val Glu Ser Ile Gly His Pro Thr Leu 
                725                 730                 735     


Pro Tyr Arg Asp Asn Leu Phe Cys Glu Trp His Leu Gln Gly Leu Ser 
            740                 745                 750         


Gly His Tyr Leu Thr Ile Ser Phe Glu Asp Phe Asn Leu Gln Asn Ser 
        755                 760                 765             


Ser Gly Cys Glu Lys Asp Phe Val Glu Ile Trp Asp Asn His Thr Ser 
    770                 775                 780                 


Gly Asn Ile Leu Gly Arg Tyr Cys Gly Asn Thr Ile Pro Asp Ser Ile 
785                 790                 795                 800 


Asp Thr Ser Ser Asn Thr Ala Val Val Arg Phe Val Thr Asp Gly Ser 
                805                 810                 815     


Val Thr Ala Ser Gly Phe Arg Leu Arg Phe Glu Ser 
            820                 825             


<210>  19
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  19

Cys Gly Gly Asn Val Tyr Ile His Asp Ala Asp Ser Ala Gly Tyr Val 
1               5                   10                  15      


Thr Ser Pro Asn His Pro His Asn Tyr Pro Pro His Ala Asp Cys Ile 
            20                  25                  30          


Trp Ile Leu Ala Ala Pro Pro Glu Thr Arg Ile Gln Leu Gln Phe Glu 
        35                  40                  45              


Asp Arg Phe Asp Ile Glu Val Thr Pro Asn Cys Thr Ser Asn Tyr Leu 
    50                  55                  60                  


Glu Leu Arg Asp Gly Val Asp Ser Asp Ala Pro Ile Leu Ser Lys Phe 
65                  70                  75                  80  


Cys Gly Thr Ser Leu Pro Ser Ser Gln Trp Ser Ser Gly Glu Val Met 
                85                  90                  95      


Tyr Leu Arg Phe Arg Ser Asp Asn Ser Pro Thr His Val Gly Phe Lys 
            100                 105                 110         


Ala Lys Tyr Ser Ile Ala Gln Cys Gly Gly Arg Val Pro Gly Gln Ser 
        115                 120                 125             


Gly Val Val Glu Ser Ile Gly His Pro Thr Leu Pro Tyr Arg Asp Asn 
    130                 135                 140                 


Leu Phe Cys Glu Trp His Leu Gln Gly Leu Ser Gly His Tyr Leu Thr 
145                 150                 155                 160 


Ile Ser Phe Glu Asp Phe Asn Leu Gln Asn Ser Ser Gly Cys Glu Lys 
                165                 170                 175     


Asp Phe Val Glu Ile Trp Asp Asn His Thr Ser Gly Asn Ile Leu Gly 
            180                 185                 190         


Arg Tyr Cys Gly Asn Thr Ile Pro Asp Ser Ile Asp Thr Ser Ser Asn 
        195                 200                 205             


Thr Ala Val Val Arg Phe Val Thr Asp Gly Ser Val Thr Ala Ser Gly 
    210                 215                 220                 


Phe Arg Leu Arg Phe Glu Ser Ser Met Glu Glu Cys Gly Gly Asp Leu 
225                 230                 235                 240 


Gln Gly Ser Ile Gly Thr Phe Thr Ser Pro Asn Tyr Pro Asn Pro Asn 
                245                 250                 255     


Pro His Gly Arg Ile Cys Glu Trp Arg Ile Thr Ala Pro Glu Gly Arg 
            260                 265                 270         


Arg Ile Thr Leu Met Phe Asn Asn Leu Arg Leu Ala Thr His Pro Ser 
        275                 280                 285             


Cys Asn Asn Glu His Val Ile Val Phe Asn Gly Ile Arg Ser Asn Ser 
    290                 295                 300                 


Pro Gln Leu Glu Lys Leu Cys Ser Ser Val Asn Val Ser Asn Glu Ile 
305                 310                 315                 320 


Lys Ser Ser Gly Asn Thr Met Lys Val Ile Phe Phe Thr Asp Gly Ser 
                325                 330                 335     


Arg Pro Tyr Gly Gly Phe Thr Ala Ser Tyr Thr Ser Ser Glu Asp Ala 
            340                 345                 350         


Val Cys Gly Gly Ser Leu Pro Asn Thr Pro Glu Gly Asn Phe Thr Ser 
        355                 360                 365             


Pro Gly Tyr Asp Gly Val Arg Asn Tyr Ser Arg Asn Leu Asn Cys Glu 
    370                 375                 380                 


Trp Thr Leu Ser Asn Pro Asn Gln Gly Asn Ser Ser Ile Ser Ile His 
385                 390                 395                 400 


Phe Glu Asp Phe Tyr Leu Glu Ser His Gln Asp Cys Gln Phe Asp Val 
                405                 410                 415     


Leu Glu Phe Arg Val Gly Asp Ala Asp Gly Pro Leu Met Trp Arg Leu 
            420                 425                 430         


Cys Gly Pro Ser Lys Pro Thr Leu Pro Leu Val Ile Pro Tyr Ser Gln 
        435                 440                 445             


Val Trp Ile His Phe Val Thr Asn Glu Arg Val Glu His Ile Gly Phe 
    450                 455                 460                 


His Ala Lys Tyr Ser Phe Thr Asp Cys Gly Gly Ile Gln Ile Gly Asp 
465                 470                 475                 480 


Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Asn Ala Tyr Asp Ser Leu 
                485                 490                 495     


Thr His Cys Ser Ser Leu Leu Glu Ala Pro Gln Gly His Thr Ile Thr 
            500                 505                 510         


Leu Thr Phe Ser Asp Phe Asp Ile Glu Pro His Thr Thr Cys Ala Trp 
        515                 520                 525             


Asp Ser Val Thr Val Arg Asn Gly Gly Ser Pro Glu Ser Pro Ile Ile 
    530                 535                 540                 


Gly Gln Tyr Cys Gly Asn Ser Asn Pro Arg Thr Ile Gln Ser Gly Ser 
545                 550                 555                 560 


Asn Gln Leu Val Val Thr Phe Asn Ser Asp His Ser Leu Gln Gly Gly 
                565                 570                 575     


Gly Phe Tyr Ala Thr Trp Asn Thr Gln Thr Leu Gly Cys Gly Gly Ile 
            580                 585                 590         


Phe His Ser Asp Asn Gly Thr Ile Arg Ser Pro His Trp Pro Gln Asn 
        595                 600                 605             


Phe Pro Glu Asn Ser Arg Cys Ser Trp Thr Ala Ile Thr His Lys Ser 
    610                 615                 620                 


Lys His Leu Glu Ile Ser Phe Asp Asn Asn Phe Leu Ile Pro Ser Gly 
625                 630                 635                 640 


Asp Gly Gln Cys Gln Asn Ser Phe Val Lys Val Trp Ala Gly Thr Glu 
                645                 650                 655     


Glu Val Asp Lys Ala Leu Leu Ala Thr Gly Cys Gly Asn Val Ala Pro 
            660                 665                 670         


Gly Pro Val Ile Thr Pro Ser Asn Thr Phe Thr Ala Val Phe Gln Ser 
        675                 680                 685             


Gln Glu Ala Pro Ala Gln Gly Phe Ser Ala Ser Phe Val Ser Arg Cys 
    690                 695                 700                 


Gly Ser Asn Phe Thr Gly Pro Ser Gly Tyr Ile Ile Ser Pro Asn Tyr 
705                 710                 715                 720 


Pro Lys Gln Tyr Asp Asn Asn Met Asn Cys Thr Tyr Val Ile Glu Ala 
                725                 730                 735     


Asn Pro Leu Ser Val Val Leu Leu Thr Phe Val Ser Phe His Leu Glu 
            740                 745                 750         


Ala Arg Ser Ala Val Thr Gly Ser Cys Val Asn Asp Gly Val His Ile 
        755                 760                 765             


Ile Arg Gly Tyr Ser Val Met Ser Thr Pro Phe Ala Thr Val Cys Gly 
    770                 775                 780                 


Asp Glu Met Pro Ala Pro Leu Thr Ile Ala Gly Pro Val Leu Leu Asn 
785                 790                 795                 800 


Phe Tyr Ser Asn Glu Gln Ile Thr Asp Phe Gly Phe Lys Phe Ser Tyr 
                805                 810                 815     


Arg Ile 
        


<210>  20
<211>  817
<212>  PRT
<213>  Homo sapiens

<400>  20

Cys Gly Gly Ile Phe His Ser Asp Asn Gly Thr Ile Arg Ser Pro His 
1               5                   10                  15      


Trp Pro Gln Asn Phe Pro Glu Asn Ser Arg Cys Ser Trp Thr Ala Ile 
            20                  25                  30          


Thr His Lys Ser Lys His Leu Glu Ile Ser Phe Asp Asn Asn Phe Leu 
        35                  40                  45              


Ile Pro Ser Gly Asp Gly Gln Cys Gln Asn Ser Phe Val Lys Val Trp 
    50                  55                  60                  


Ala Gly Thr Glu Glu Val Asp Lys Ala Leu Leu Ala Thr Gly Cys Gly 
65                  70                  75                  80  


Asn Val Ala Pro Gly Pro Val Ile Thr Pro Ser Asn Thr Phe Thr Ala 
                85                  90                  95      


Val Phe Gln Ser Gln Glu Ala Pro Ala Gln Gly Phe Ser Ala Ser Phe 
            100                 105                 110         


Val Ser Arg Cys Gly Ser Asn Phe Thr Gly Pro Ser Gly Tyr Ile Ile 
        115                 120                 125             


Ser Pro Asn Tyr Pro Lys Gln Tyr Asp Asn Asn Met Asn Cys Thr Tyr 
    130                 135                 140                 


Val Ile Glu Ala Asn Pro Leu Ser Val Val Leu Leu Thr Phe Val Ser 
145                 150                 155                 160 


Phe His Leu Glu Ala Arg Ser Ala Val Thr Gly Ser Cys Val Asn Asp 
                165                 170                 175     


Gly Val His Ile Ile Arg Gly Tyr Ser Val Met Ser Thr Pro Phe Ala 
            180                 185                 190         


Thr Val Cys Gly Asp Glu Met Pro Ala Pro Leu Thr Ile Ala Gly Pro 
        195                 200                 205             


Val Leu Leu Asn Phe Tyr Ser Asn Glu Gln Ile Thr Asp Phe Gly Phe 
    210                 215                 220                 


Lys Phe Ser Tyr Arg Ile Ile Ser Cys Gly Gly Val Phe Asn Phe Ser 
225                 230                 235                 240 


Ser Gly Ile Ile Thr Ser Pro Ala Tyr Ser Tyr Ala Asp Tyr Pro Asn 
                245                 250                 255     


Asp Met His Cys Leu Tyr Thr Ile Thr Val Ser Asp Asp Lys Val Ile 
            260                 265                 270         


Glu Leu Lys Phe Ser Asp Phe Asp Val Val Pro Ser Thr Ser Cys Ser 
        275                 280                 285             


His Asp Tyr Leu Ala Ile Tyr Asp Gly Ala Asn Thr Ser Asp Pro Leu 
    290                 295                 300                 


Leu Gly Lys Phe Cys Gly Ser Lys Arg Pro Pro Asn Val Lys Ser Ser 
305                 310                 315                 320 


Asn Asn Ser Met Leu Leu Val Phe Lys Thr Asp Ser Phe Gln Thr Ala 
                325                 330                 335     


Lys Gly Trp Lys Met Ser Phe Arg Gln Thr Leu Gly Pro Gln Gln Gly 
            340                 345                 350         


Cys Gly Gly Tyr Leu Thr Gly Ser Asn Asn Thr Phe Ala Ser Pro Asp 
        355                 360                 365             


Ser Asp Ser Asn Gly Met Tyr Asp Lys Asn Leu Asn Cys Val Trp Ile 
    370                 375                 380                 


Ile Ile Ala Pro Val Asn Lys Val Ile His Leu Thr Phe Asn Thr Phe 
385                 390                 395                 400 


Ala Leu Glu Ala Ala Ser Thr Arg Gln Arg Cys Leu Tyr Asp Tyr Val 
                405                 410                 415     


Lys Leu Tyr Asp Gly Asp Ser Glu Asn Ala Asn Leu Ala Gly Thr Phe 
            420                 425                 430         


Cys Gly Ser Thr Val Pro Ala Pro Phe Ile Ser Ser Gly Asn Phe Leu 
        435                 440                 445             


Thr Val Gln Phe Ile Ser Asp Leu Thr Leu Glu Arg Glu Gly Phe Asn 
    450                 455                 460                 


Ala Thr Tyr Thr Ile Met Asp Met Pro Cys Gly Gly Thr Tyr Asn Ala 
465                 470                 475                 480 


Thr Trp Thr Pro Gln Asn Ile Ser Ser Pro Asn Ser Ser Asp Pro Asp 
                485                 490                 495     


Val Pro Phe Ser Ile Cys Thr Trp Val Ile Asp Ser Pro Pro His Gln 
            500                 505                 510         


Gln Val Lys Ile Thr Val Trp Ala Leu Gln Leu Thr Ser Gln Asp Cys 
        515                 520                 525             


Thr Gln Asn Tyr Leu Gln Leu Gln Asp Ser Pro Gln Gly His Gly Asn 
    530                 535                 540                 


Ser Arg Phe Gln Phe Cys Gly Arg Asn Ala Ser Ala Val Pro Val Phe 
545                 550                 555                 560 


Tyr Ser Ser Met Ser Thr Ala Met Val Ile Phe Lys Ser Gly Val Val 
                565                 570                 575     


Asn Arg Asn Ser Arg Met Ser Phe Thr Tyr Gln Ile Ala Asp Cys Asn 
            580                 585                 590         


Arg Asp Tyr His Lys Ala Phe Gly Asn Leu Arg Ser Pro Gly Trp Pro 
        595                 600                 605             


Asp Asn Tyr Asp Asn Asp Lys Asp Cys Thr Val Thr Leu Thr Ala Pro 
    610                 615                 620                 


Gln Asn His Thr Ile Ser Leu Phe Phe His Ser Leu Gly Ile Glu Asn 
625                 630                 635                 640 


Ser Val Glu Cys Arg Asn Asp Phe Leu Glu Val Arg Asn Gly Ser Asn 
                645                 650                 655     


Ser Asn Ser Pro Leu Leu Gly Lys Tyr Cys Gly Thr Leu Leu Pro Asn 
            660                 665                 670         


Pro Val Phe Ser Gln Asn Asn Glu Leu Tyr Leu Arg Phe Lys Ser Asp 
        675                 680                 685             


Ser Val Thr Ser Asp Arg Gly Tyr Glu Ile Ile Trp Thr Ser Ser Pro 
    690                 695                 700                 


Ser Gly Cys Gly Gly Thr Leu Tyr Gly Asp Arg Gly Ser Phe Thr Ser 
705                 710                 715                 720 


Pro Gly Tyr Pro Gly Thr Tyr Pro Asn Asn Thr Tyr Cys Glu Trp Val 
                725                 730                 735     


Leu Val Ala Pro Ala Gly Arg Leu Val Thr Ile Asn Phe Tyr Phe Ile 
            740                 745                 750         


Ser Ile Asp Asp Pro Gly Asp Cys Val Gln Asn Tyr Leu Thr Leu Tyr 
        755                 760                 765             


Asp Gly Pro Asn Ala Ser Ser Pro Ser Ser Gly Pro Tyr Cys Gly Gly 
    770                 775                 780                 


Asp Thr Ser Ile Ala Pro Phe Val Ala Ser Ser Asn Gln Val Phe Ile 
785                 790                 795                 800 


Lys Phe His Ala Asp Tyr Ala Arg Arg Pro Ser Ala Phe Arg Leu Thr 
                805                 810                 815     


Trp 
    


