                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
       Stockwell, Brent R.
 
<120>  E3 BINDING POCKETS AND IDENTIFICATION AND USE OF E3 LIGASE 
       INHIBITORS

<130>  0304815

<150>  61/355,929
<151>  2010-06-17

<150>  61/356,496
<151>  2010-06-18

<160>  47    

<170>  PatentIn version 3.3

<210>  1
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Gly Asn Val Lys Lys Ser Ser Gly Ala Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Ser Gly Ser Gly Gly Leu Ile Gly Leu Met Lys Asp Ala 
            20                  25                  30          


Phe Gln Pro His His His His His His His Leu Ser Pro His Pro Pro 
        35                  40                  45              


Gly Thr Val Asp Lys Lys Met Val Glu Lys Cys Trp Lys Leu Met Asp 
    50                  55                  60                  


Lys Val Val Arg Leu Cys Gln Asn Pro Lys Leu Ala Leu Lys Asn Ser 
65                  70                  75                  80  


Pro Pro Tyr Ile Leu Asp Leu Leu Pro Asp Thr Tyr Gln His Leu Arg 
                85                  90                  95      


Thr Ile Leu Ser Arg Tyr Glu Gly Lys Met Glu Thr Leu Gly Glu Asn 
            100                 105                 110         


Glu Tyr Phe Arg Val Phe Met Glu Asn Leu Met Lys Lys Thr Lys Gln 
        115                 120                 125             


Thr Ile Ser Leu Phe Lys Glu Gly Lys Glu Arg Met Tyr Glu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Arg Arg Asn Leu Thr Lys Leu Ser Leu Ile Phe Ser His 
145                 150                 155                 160 


Met Leu Ala Glu Leu Lys Gly Ile Phe Pro Ser Gly Leu Phe Gln Gly 
                165                 170                 175     


Asp Thr Phe Arg Ile Thr Lys Ala Asp Ala Ala Glu Phe Trp Arg Lys 
            180                 185                 190         


Ala Phe Gly Glu Lys Thr Ile Val Pro Trp Lys Ser Phe Arg Gln Ala 
        195                 200                 205             


Leu His Glu Val His Pro Ile Ser Ser Gly Leu Glu Ala Met Ala Leu 
    210                 215                 220                 


Lys Ser Thr Ile Asp Leu Thr Cys Asn Asp Tyr Ile Ser Val Phe Glu 
225                 230                 235                 240 


Phe Asp Ile Phe Thr Arg Leu Phe Gln Pro Trp Ser Ser Leu Leu Arg 
                245                 250                 255     


Asn Trp Asn Ser Leu Ala Val Thr His Pro Gly Tyr Met Ala Phe Leu 
            260                 265                 270         


Thr Tyr Asp Glu Val Lys Ala Arg Leu Gln Lys Phe Ile His Lys Pro 
        275                 280                 285             


Gly Ser Tyr Ile Phe Arg Leu Ser Cys Thr Arg Leu Gly Gln Trp Ala 
    290                 295                 300                 


Ile Gly Tyr Val Thr Ala Asp Gly Asn Ile Leu Gln Thr Ile Pro His 
305                 310                 315                 320 


Asn Lys Pro Leu Phe Gln Ala Leu Ile Asp Gly Phe Arg Glu Gly Phe 
                325                 330                 335     


Tyr Leu Phe Pro Asp Gly Arg Asn Gln Asn Pro Asp Leu Thr Gly Leu 
            340                 345                 350         


Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr 
        355                 360                 365             


Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys 
    370                 375                 380                 


Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met 
385                 390                 395                 400 


Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys 
                405                 410                 415     


Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp 
            420                 425                 430         


Pro Phe Asp Pro Arg Gly Ser Gly Ser Leu Leu Arg Gln Gly Ala Glu 
        435                 440                 445             


Gly Ala Pro Ser Pro Asn Tyr Asp Asp Asp Asp Asp Glu Arg Ala Asp 
    450                 455                 460                 


Asp Thr Leu Phe Met Met Lys Glu Leu Ala Gly Ala Lys Val Glu Arg 
465                 470                 475                 480 


Pro Pro Ser Pro Phe Ser Met Ala Pro Gln Ala Ser Leu Pro Pro Val 
                485                 490                 495     


Pro Pro Arg Leu Asp Leu Leu Pro Gln Arg Val Cys Val Pro Ser Ser 
            500                 505                 510         


Ala Ser Ala Leu Gly Thr Ala Ser Lys Ala Ala Ser Gly Ser Leu His 
        515                 520                 525             


Lys Asp Lys Pro Leu Pro Val Pro Pro Thr Leu Arg Asp Leu Pro Pro 
    530                 535                 540                 


Pro Pro Pro Pro Asp Arg Pro Tyr Ser Val Gly Ala Glu Ser Arg Pro 
545                 550                 555                 560 


Gln Arg Arg Pro Leu Pro Cys Thr Pro Gly Asp Cys Pro Ser Arg Asp 
                565                 570                 575     


Lys Leu Pro Pro Val Pro Ser Ser Arg Leu Gly Asp Ser Trp Leu Pro 
            580                 585                 590         


Arg Pro Ile Pro Lys Val Pro Val Ser Ala Pro Ser Ser Ser Asp Pro 
        595                 600                 605             


Trp Thr Gly Arg Glu Leu Thr Asn Arg His Ser Leu Pro Phe Ser Leu 
    610                 615                 620                 


Pro Ser Gln Met Glu Pro Arg Pro Asp Val Pro Arg Leu Gly Ser Thr 
625                 630                 635                 640 


Phe Ser Leu Asp Thr Ser Met Ser Met Asn Ser Ser Pro Leu Val Gly 
                645                 650                 655     


Pro Glu Cys Asp His Pro Lys Ile Lys Pro Ser Ser Ser Ala Asn Ala 
            660                 665                 670         


Ile Tyr Ser Leu Ala Ala Arg Pro Leu Pro Val Pro Lys Leu Pro Pro 
        675                 680                 685             


Gly Glu Gln Cys Glu Gly Glu Glu Asp Thr Glu Tyr Met Thr Pro Ser 
    690                 695                 700                 


Ser Arg Pro Leu Arg Pro Leu Asp Thr Ser Gln Ser Ser Arg Ala Cys 
705                 710                 715                 720 


Asp Cys Asp Gln Gln Ile Asp Ser Cys Thr Tyr Glu Ala Met Tyr Asn 
                725                 730                 735     


Ile Gln Ser Gln Ala Pro Ser Ile Thr Glu Ser Ser Thr Phe Gly Glu 
            740                 745                 750         


Gly Asn Leu Ala Ala Ala His Ala Asn Thr Gly Pro Glu Glu Ser Glu 
        755                 760                 765             


Asn Glu Asp Asp Gly Tyr Asp Val Pro Lys Pro Pro Val Pro Ala Val 
    770                 775                 780                 


Leu Ala Arg Arg Thr Leu Ser Asp Ile Ser Asn Ala Ser Ser Ser Phe 
785                 790                 795                 800 


Gly Trp Leu Ser Leu Asp Gly Asp Pro Thr Thr Asn Val Thr Glu Gly 
                805                 810                 815     


Ser Gln Val Pro Glu Arg Pro Pro Lys Pro Phe Pro Arg Arg Ile Asn 
            820                 825                 830         


Ser Glu Arg Lys Ala Gly Ser Cys Gln Gln Gly Ser Gly Pro Ala Ala 
        835                 840                 845             


Ser Ala Ala Thr Ala Ser Pro Gln Leu Ser Ser Glu Ile Glu Asn Leu 
    850                 855                 860                 


Met Ser Gln Gly Tyr Ser Tyr Gln Asp Ile Gln Lys Ala Leu Val Ile 
865                 870                 875                 880 


Ala Gln Asn Asn Ile Glu Met Ala Lys Asn Ile Leu Arg Glu Phe Val 
                885                 890                 895     


Ser Ile Ser Ser Pro Ala His Val Ala Thr 
            900                 905     


<210>  2
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ser Arg Arg Leu Met Lys Glu Leu Glu Glu Ile Arg Lys 
1               5                   10                  15      


Cys Gly Met Lys Asn Phe Arg Asn Ile Gln Val Asp Glu Ala Asn Leu 
            20                  25                  30          


Leu Thr Trp Gln Gly Leu Ile Val Pro Asp Asn Pro Pro Tyr Asp Lys 
        35                  40                  45              


Gly Ala Phe Arg Ile Glu Ile Asn Phe Pro Ala Glu Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Lys Ile Thr Phe Lys Thr Lys Ile Tyr His Pro Asn Ile Asp 
65                  70                  75                  80  


Glu Lys Gly Gln Val Cys Leu Pro Val Ile Ser Ala Glu Asn Trp Lys 
                85                  90                  95      


Pro Ala Thr Lys Thr Asp Gln Val Ile Gln Ser Leu Ile Ala Leu Val 
            100                 105                 110         


Asn Asp Pro Gln Pro Glu His Pro Leu Arg Ala Asp Leu Ala Glu Glu 
        115                 120                 125             


Tyr Ser Lys Asp Arg Lys Lys Phe Cys Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 


Lys Lys Tyr Gly Glu Lys Arg Pro Val Asp 
145                 150                 


<210>  3
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  3
caagaccata tcaaagtgac ccaggaacaa tatgaattat actgtgagat gggctccaca     60

ttccaactat gtaaaatatg tgctgaaaat gataaggatg taaagattga gccctgtgga    120

cacctcatgt gcacatcctg tcttacatcc tggcaggaat cagaaggtca gggctgtcct    180

ttctgccgat gtgaaattaa aggtactgaa cccatcgtgg tagatccgtt tgatcctaga    240

gggagtggca gcctgttgag gcaaggagca gagggagctc cctccccaaa ttatgatgat    300

gatgatgatg aacgagctga tgatactctc ttcatgatga aggaa                    345


<210>  4
<211>  84
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  4

Gly Leu Cys Glu Pro Thr Pro Gln Asp His Ile Lys Val Thr Gln Glu 
1               5                   10                  15      


Gln Tyr Glu Leu Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys 
            20                  25                  30          


Ile Cys Ala Glu Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His 
        35                  40                  45              


Leu Met Cys Thr Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln 
    50                  55                  60                  


Gly Cys Pro Phe Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val 
65                  70                  75                  80  


Val Asp Pro Phe 
                


<210>  5
<211>  68
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  5

Met Ala Thr Val Ala Glu Arg Cys Pro Ile Cys Leu Glu Asp Pro Ser 
1               5                   10                  15      


Asn Tyr Ser Met Ala Leu Pro Cys Leu His Ala Phe Cys Tyr Val Cys 
            20                  25                  30          


Ile Thr Arg Trp Ile Arg Gln Asn Pro Thr Cys Pro Leu Cys Lys Val 
        35                  40                  45              


Pro Val Glu Ser Val Val His Thr Ile Glu Ser Asp Ser Glu Phe Gly 
    50                  55                  60                  


Asp Gln Leu Ile 
65              


<210>  6
<211>  78
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  6

Met Ser Arg Ser Pro Asp Ala Lys Glu Asp Pro Val Glu Cys Pro Leu 
1               5                   10                  15      


Cys Met Glu Pro Leu Glu Ile Asp Asp Ile Asn Phe Phe Pro Cys Thr 
            20                  25                  30          


Cys Gly Tyr Gln Ile Cys Arg Phe Cys Trp His Arg Ile Arg Thr Asp 
        35                  40                  45              


Glu Asn Gly Leu Cys Pro Ala Cys Arg Lys Pro Tyr Pro Glu Asp Pro 
    50                  55                  60                  


Ala Val Tyr Lys Pro Leu Ser Gln Glu Glu Leu Gln Arg Ile 
65                  70                  75              


<210>  7
<211>  89
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  7

Gly Ser Ser Gly Ser Ser Gly Pro Arg Glu Pro Val Val Asn Asp Glu 
1               5                   10                  15      


Met Cys Asp Val Cys Glu Val Trp Thr Ala Glu Ser Leu Phe Pro Cys 
            20                  25                  30          


Arg Val Cys Thr Arg Val Phe His Asp Gly Cys Leu Arg Arg Met Gly 
        35                  40                  45              


Tyr Ile Gln Gly Asp Ser Ala Ala Glu Val Thr Glu Met Ala His Thr 
    50                  55                  60                  


Glu Thr Gly Trp Ser Cys His Tyr Cys Asp Asn Ile Asn Leu Leu Leu 
65                  70                  75                  80  


Thr Glu Glu Ser Gly Pro Ser Ser Gly 
                85                  


<210>  8
<211>  74
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  8

Gly Ser Ser Gly Ser Ser Gly Arg Glu Thr Tyr Pro Asp Ala Val Lys 
1               5                   10                  15      


Ile Cys Asn Ile Cys His Ser Leu Leu Ile Gln Gly Gln Ser Cys Glu 
            20                  25                  30          


Thr Cys Gly Ile Arg Met His Leu Pro Cys Val Ala Lys Tyr Phe Gln 
        35                  40                  45              


Ser Asn Ala Glu Pro Arg Cys Pro His Cys Asn Asp Tyr Trp Pro His 
    50                  55                  60                  


Glu Ile Pro Lys Ser Gly Pro Ser Ser Gly 
65                  70                  


<210>  9
<211>  88
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  9

Gly Ser Ser Gly Ser Ser Gly Asn Leu Asp Ala Leu Arg Glu Val Leu 
1               5                   10                  15      


Glu Cys Pro Ile Cys Met Glu Ser Phe Thr Glu Glu Gln Leu Arg Pro 
            20                  25                  30          


Lys Leu Leu His Cys Gly His Thr Ile Cys Arg Gln Cys Leu Glu Lys 
        35                  40                  45              


Leu Leu Ala Ser Ser Ile Asn Gly Val Arg Cys Pro Phe Cys Ser Lys 
    50                  55                  60                  


Ile Thr Arg Ile Thr Ser Leu Thr Gln Leu Thr Asp Asn Leu Thr Val 
65                  70                  75                  80  


Leu Lys Ser Gly Pro Ser Ser Gly 
                85              


<210>  10
<211>  86
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  10

Gly Ser Ser Gly Ser Ser Gly Ala Leu Phe His Lys Lys Leu Thr Glu 
1               5                   10                  15      


Gly Val Leu Met Arg Asp Pro Lys Phe Leu Trp Cys Ala Gln Cys Ser 
            20                  25                  30          


Phe Gly Phe Ile Tyr Glu Arg Glu Gln Leu Glu Ala Thr Cys Pro Gln 
        35                  40                  45              


Cys His Gln Thr Phe Cys Val Arg Cys Lys Arg Gln Trp Glu Glu Gln 
    50                  55                  60                  


His Arg Gly Arg Ser Cys Glu Asp Phe Gln Asn Trp Lys Arg Met Asn 
65                  70                  75                  80  


Ser Gly Pro Ser Ser Gly 
                85      


<210>  11
<211>  81
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  11

Gly Ser Ser Gly Ser Ser Gly Gly Ser Glu Glu Glu Glu Ile Pro Phe 
1               5                   10                  15      


Arg Cys Phe Ile Cys Arg Gln Ala Phe Gln Asn Pro Val Val Thr Lys 
            20                  25                  30          


Cys Arg His Tyr Phe Cys Glu Ser Cys Ala Leu Glu His Phe Arg Ala 
        35                  40                  45              


Thr Pro Arg Cys Tyr Ile Cys Asp Gln Pro Thr Gly Gly Ile Phe Asn 
    50                  55                  60                  


Pro Ala Lys Glu Leu Met Ala Lys Leu Gln Lys Ser Gly Pro Ser Ser 
65                  70                  75                  80  


Gly 
    


<210>  12
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  12

Gly Ser Ser Gly Ser Ser Gly Thr Ser Ile Thr Pro Ser Ser Gln Asp 
1               5                   10                  15      


Ile Cys Arg Ile Cys His Cys Glu Gly Asp Asp Glu Ser Pro Leu Ile 
            20                  25                  30          


Thr Pro Cys His Cys Thr Gly Ser Leu His Phe Val His Gln Ala Cys 
        35                  40                  45              


Leu Gln Gln Trp Ile Lys Ser Ser Asp Thr Arg Cys Cys Glu Leu Cys 
    50                  55                  60                  


Lys Tyr Glu Phe Ile Met Glu Thr Lys Leu Ser Gly Pro Ser Ser Gly 
65                  70                  75                  80  


<210>  13
<211>  71
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  13

Gly Ser Ser Gly Ser Ser Gly Asn Thr Ala Pro Ser Leu Thr Val Pro 
1               5                   10                  15      


Glu Cys Ala Ile Cys Leu Gln Thr Cys Val His Pro Val Ser Leu Pro 
            20                  25                  30          


Cys Lys His Val Phe Cys Tyr Leu Cys Val Lys Gly Ala Ser Trp Leu 
        35                  40                  45              


Gly Lys Arg Cys Ala Leu Cys Arg Gln Glu Ile Pro Glu Asp Phe Leu 
    50                  55                  60                  


Asp Ser Gly Pro Ser Ser Gly 
65                  70      


<210>  14
<211>  72
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  14

Gly Ser Ser Gly Ser Ser Gly Asn Leu Ser Glu Leu Thr Pro Tyr Ile 
1               5                   10                  15      


Leu Cys Ser Ile Cys Lys Gly Tyr Leu Ile Asp Ala Thr Thr Ile Thr 
            20                  25                  30          


Glu Cys Leu His Thr Phe Cys Lys Ser Cys Ile Val Arg His Phe Tyr 
        35                  40                  45              


Tyr Ser Asn Arg Cys Pro Lys Cys Asn Ile Val Val His Gln Thr Gln 
    50                  55                  60                  


Pro Leu Ser Gly Pro Ser Ser Gly 
65                  70          


<210>  15
<211>  68
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Gly Ser Ser Gly Ser Ser Gly Val Glu Pro Ser Glu Glu Asn Ser Lys 
1               5                   10                  15      


Asp Cys Val Val Cys Gln Asn Gly Thr Val Asn Trp Val Leu Leu Pro 
            20                  25                  30          


Cys Arg His Thr Cys Leu Cys Asp Gly Cys Val Lys Tyr Phe Gln Gln 
        35                  40                  45              


Cys Pro Met Cys Arg Gln Phe Val Gln Glu Ser Phe Ala Leu Ser Gly 
    50                  55                  60                  


Pro Ser Ser Gly 
65              


<210>  16
<211>  75
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  16

Gly Ser Ser Gly Ser Ser Gly Ser Leu Gln Lys Glu Ile Ser Thr Glu 
1               5                   10                  15      


Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys Leu Cys Lys Ile Cys Met 
            20                  25                  30          


Asp Arg Asn Ile Ala Ile Val Phe Val Pro Cys Gly His Leu Val Thr 
        35                  40                  45              


Cys Lys Gln Cys Ala Glu Ala Val Asp Lys Cys Pro Met Cys Tyr Thr 
    50                  55                  60                  


Val Ile Thr Phe Lys Gln Lys Ile Phe Met Ser 
65                  70                  75  


<210>  17
<211>  86
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  17

Gly Ser Ser Gly Ser Ser Gly Met Glu Glu Ile Gln Gly Tyr Asp Val 
1               5                   10                  15      


Glu Phe Asp Pro Pro Leu Glu Ser Lys Tyr Glu Cys Pro Ile Cys Leu 
            20                  25                  30          


Met Ala Leu Arg Glu Ala Val Gln Thr Pro Cys Gly His Arg Phe Cys 
        35                  40                  45              


Lys Ala Cys Ile Ile Lys Ser Ile Arg Asp Ala Gly His Lys Cys Pro 
    50                  55                  60                  


Val Asp Asn Glu Ile Leu Leu Glu Asn Gln Leu Phe Pro Asp Asn Phe 
65                  70                  75                  80  


Ala Lys Arg Glu Ile Leu 
                85      


<210>  18
<211>  58
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  18

Gly Ser Ser Gly Ser Ser Gly Ala Leu Glu Asn Leu Gln Val Glu Ala 
1               5                   10                  15      


Ser Cys Ser Val Cys Leu Glu Tyr Leu Lys Glu Pro Val Ile Ile Glu 
            20                  25                  30          


Cys Gly His Asn Phe Cys Lys Ala Cys Ile Thr Arg Trp Trp Glu Asp 
        35                  40                  45              


Leu Glu Arg Asp Phe Pro Cys Pro Val Cys 
    50                  55              


<210>  19
<211>  81
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  19

Gly Ser Ser Gly Ser Ser Gly Met Trp Ser Trp Asp Val Glu Cys Asp 
1               5                   10                  15      


Thr Cys Ala Ile Cys Arg Val Gln Val Met Asp Ala Cys Leu Arg Cys 
            20                  25                  30          


Gln Ala Glu Asn Lys Gln Glu Asp Cys Val Val Val Trp Gly Glu Cys 
        35                  40                  45              


Asn His Ser Phe His Asn Cys Cys Met Ser Leu Trp Val Lys Gln Asn 
    50                  55                  60                  


Asn Arg Cys Pro Leu Cys Gln Gln Asp Trp Val Val Gln Arg Ile Gly 
65                  70                  75                  80  


Lys 
    


<210>  20
<211>  55
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  20

Gly Ser Ser Gly Ser Ser Gly Cys Pro Ile Cys Leu Glu Asp Ile His 
1               5                   10                  15      


Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His Leu Leu His 
            20                  25                  30          


Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr Arg Cys Pro Leu 
        35                  40                  45              


Cys Ser Gly Pro Ser Ser Gly 
    50                  55  


<210>  21
<211>  70
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  21

Gly Ser Ser Gly Ser Ser Gly Arg Val Lys Gln Leu Thr Asp Glu Glu 
1               5                   10                  15      


Glu Cys Cys Ile Cys Met Asp Gly Arg Ala Asp Leu Ile Leu Pro Cys 
            20                  25                  30          


Ala His Ser Phe Cys Gln Lys Cys Ile Asp Lys Trp Ser Asp Arg His 
        35                  40                  45              


Arg Asn Cys Pro Ile Cys Arg Leu Gln Met Thr Gly Ala Asn Glu Ser 
    50                  55                  60                  


Ser Gly Pro Ser Ser Gly 
65                  70  


<210>  22
<211>  78
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  22

Gly Ser Ser Gly Ser Ser Gly Thr Glu Glu His Val Gly Ser Gly Leu 
1               5                   10                  15      


Glu Cys Pro Val Cys Lys Glu Asp Tyr Ala Leu Gly Glu Ser Val Arg 
            20                  25                  30          


Gln Leu Pro Cys Asn His Leu Phe His Asp Ser Cys Ile Val Pro Trp 
        35                  40                  45              


Leu Glu Gln His Asp Ser Cys Pro Val Cys Arg Lys Ser Leu Thr Gly 
    50                  55                  60                  


Gln Asn Thr Ala Thr Asn Pro Pro Gly Leu Thr Gly Val Gly 
65                  70                  75              


<210>  23
<211>  85
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  23

Gly Ser Ser Gly Ser Ser Gly Met Ala Ser Gly Ile Leu Val Asn Val 
1               5                   10                  15      


Lys Glu Glu Val Thr Cys Pro Ile Cys Leu Glu Leu Leu Thr Gln Pro 
            20                  25                  30          


Leu Ser Leu Asp Cys Gly His Ser Phe Cys Gln Ala Cys Leu Thr Ala 
        35                  40                  45              


Asn His Lys Lys Ser Met Leu Asp Lys Gly Glu Ser Ser Cys Pro Val 
    50                  55                  60                  


Cys Arg Ile Ser Tyr Gln Pro Glu Asn Ile Arg Pro Asn Arg His Val 
65                  70                  75                  80  


Ala Asn Ile Val Glu 
                85  


<210>  24
<211>  85
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  24

Gly Ser Ser Gly Ser Ser Gly Met Ala Ser Ser Val Leu Glu Met Ile 
1               5                   10                  15      


Lys Glu Glu Val Thr Cys Pro Ile Cys Leu Glu Leu Leu Lys Glu Pro 
            20                  25                  30          


Val Ser Ala Asp Cys Asn His Ser Phe Cys Arg Ala Cys Ile Thr Leu 
        35                  40                  45              


Asn Tyr Glu Ser Asn Arg Asn Thr Asp Gly Lys Gly Asn Cys Pro Val 
    50                  55                  60                  


Cys Arg Val Pro Tyr Pro Phe Gly Asn Leu Lys Pro Asn Leu His Val 
65                  70                  75                  80  


Ala Asn Ile Val Glu 
                85  


<210>  25
<211>  66
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  25

Gly Ser Ser Gly Ser Ser Gly Phe Val Lys Thr Val Glu Asp Lys Tyr 
1               5                   10                  15      


Lys Cys Glu Lys Cys His Leu Val Leu Cys Ser Pro Lys Gln Thr Glu 
            20                  25                  30          


Cys Gly His Arg Phe Cys Glu Ser Cys Met Ala Ala Leu Leu Ser Ser 
        35                  40                  45              


Ser Ser Pro Lys Cys Thr Ala Cys Gln Glu Ser Ile Val Lys Asp Lys 
    50                  55                  60                  


Val Phe 
65      


<210>  26
<211>  79
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  26

Gly Ser Ser Gly Ser Ser Gly Asn Val Gln Glu Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Leu Cys Arg Ala Cys Ile Thr Val Ser Asn Lys Glu Ala Val Thr 
        35                  40                  45              


Ser Met Gly Gly Lys Ser Ser Cys Pro Val Cys Gly Ile Ser Tyr Ser 
    50                  55                  60                  


Phe Glu His Leu Gln Ala Asn Gln His Leu Ala Asn Ile Val Glu 
65                  70                  75                  


<210>  27
<211>  63
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  27

Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg 
1               5                   10                  15      


Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala 
            20                  25                  30          


Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro 
        35                  40                  45              


Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
    50                  55                  60              


<210>  28
<211>  63
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  28

Ser Leu Pro Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg 
1               5                   10                  15      


Pro Lys Asn Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala 
            20                  25                  30          


Cys Phe Thr Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro 
        35                  40                  45              


Val Cys Arg Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
    50                  55                  60              


<210>  29
<211>  52
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  29

Glu Asn Val Ser Gln Gln Asn Cys Pro Ile Cys Leu Glu Asp Ile His 
1               5                   10                  15      


Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His Leu Leu His 
            20                  25                  30          


Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr Arg Cys Pro Leu 
        35                  40                  45              


Cys Met His Ser 
    50          


<210>  30
<211>  83
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  30

Gly Ser Leu Gln Asp His Ile Lys Val Thr Gln Glu Gln Tyr Glu Leu 
1               5                   10                  15      


Tyr Cys Glu Met Gly Ser Thr Phe Gln Leu Cys Lys Ile Cys Ala Glu 
            20                  25                  30          


Asn Asp Lys Asp Val Lys Ile Glu Pro Cys Gly His Leu Met Cys Thr 
        35                  40                  45              


Ser Cys Leu Thr Ser Trp Gln Glu Ser Glu Gly Gln Gly Cys Pro Phe 
    50                  55                  60                  


Cys Arg Cys Glu Ile Lys Gly Thr Glu Pro Ile Val Val Asp Pro Phe 
65                  70                  75                  80  


Asp Pro Arg 
            


<210>  31
<211>  69
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  31

Met Lys Gln Asp Gly Glu Glu Gly Thr Glu Glu Asp Thr Glu Glu Lys 
1               5                   10                  15      


Cys Thr Ile Cys Leu Ser Ile Leu Glu Glu Gly Glu Asp Val Arg Arg 
            20                  25                  30          


Leu Pro Cys Met His Leu Phe His Gln Val Cys Val Asp Gln Trp Leu 
        35                  40                  45              


Ile Thr Asn Lys Lys Cys Pro Ile Cys Arg Val Asp Ile Glu Ala Gln 
    50                  55                  60                  


Leu Pro Ser Glu Ser 
65                  


<210>  32
<211>  60
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  32

Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn 
1               5                   10                  15      


Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr 
            20                  25                  30          


Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg 
        35                  40                  45              


Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
    50                  55                  60  


<210>  33
<211>  61
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  33

Cys Gln Asn Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg 
1               5                   10                  15      


Asp Gly Asn Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys Phe 
            20                  25                  30          


His Cys Ala Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys 
        35                  40                  45              


Lys Lys Glu Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
    50                  55                  60      


<210>  34
<211>  60
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  34

Leu Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn 
1               5                   10                  15      


Gly Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr 
            20                  25                  30          


Cys Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg 
        35                  40                  45              


Gln Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
    50                  55                  60  


<210>  35
<211>  62
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  35

Asp Cys Gln Asn Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro 
1               5                   10                  15      


Arg Asp Gly Asn Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys 
            20                  25                  30          


Phe His Cys Ala Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile 
        35                  40                  45              


Cys Lys Lys Glu Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
    50                  55                  60          


<210>  36
<211>  64
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  36

Gly Ala Met Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile 
1               5                   10                  15      


Val Gln Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His Val Phe 
            20                  25                  30          


Cys Ser Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr Cys Pro 
        35                  40                  45              


Thr Cys Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile Tyr Ile 
    50                  55                  60                  


<210>  37
<211>  63
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  37

Gly Ser Ser Gly Ser Ser Gly Met Ala Ser Gly Gln Phe Val Asn Lys 
1               5                   10                  15      


Leu Gln Glu Glu Val Ile Cys Pro Ile Cys Leu Asp Ile Leu Gln Lys 
            20                  25                  30          


Pro Val Thr Ile Asp Cys Gly His Asn Phe Cys Leu Lys Cys Ile Thr 
        35                  40                  45              


Gln Ile Gly Glu Thr Ser Cys Gly Phe Phe Lys Cys Pro Leu Cys 
    50                  55                  60              


<210>  38
<211>  73
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  38

Gly Ser Ser Gly Ser Ser Gly Met Ala Ser Gly Gln Phe Val Asn Lys 
1               5                   10                  15      


Leu Gln Glu Glu Val Ile Cys Pro Ile Cys Leu Asp Ile Leu Gln Lys 
            20                  25                  30          


Pro Val Thr Ile Asp Cys Gly His Asn Phe Cys Leu Lys Cys Ile Thr 
        35                  40                  45              


Gln Ile Gly Glu Thr Ser Cys Gly Phe Phe Lys Cys Pro Leu Cys Lys 
    50                  55                  60                  


Thr Ser Val Arg Lys Asn Ala Ile Arg 
65                  70              


<210>  39
<211>  74
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  39

Gly Ser Ser Gly Ser Ser Gly Glu Asp Asp Pro Ile Pro Asp Glu Leu 
1               5                   10                  15      


Leu Cys Leu Ile Cys Lys Asp Ile Met Thr Asp Ala Val Val Ile Pro 
            20                  25                  30          


Cys Cys Gly Asn Ser Tyr Cys Asp Glu Cys Ile Arg Thr Ala Leu Leu 
        35                  40                  45              


Glu Ser Asp Glu His Thr Cys Pro Thr Cys His Gln Asn Asp Val Ser 
    50                  55                  60                  


Pro Asp Ala Leu Ser Gly Pro Ser Ser Gly 
65                  70                  


<210>  40
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  40

Ser Asp Leu Pro Val Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg 
1               5                   10                  15      


Thr Cys Lys Val Cys Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro 
            20                  25                  30          


Cys Gly His Leu Val Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys 
        35                  40                  45              


Cys Pro Ile Cys Arg Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu 
    50                  55                  60                  


Ser 
65  


<210>  41
<211>  64
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  41

Asp Leu Pro Val Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr 
1               5                   10                  15      


Cys Lys Val Cys Met Asp Lys Glu Val Ser Ile Val Phe Ile Pro Cys 
            20                  25                  30          


Gly His Leu Val Val Cys Lys Asp Cys Ala Pro Ser Leu Arg Lys Cys 
        35                  40                  45              


Pro Ile Cys Arg Ser Thr Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    50                  55                  60                  


<210>  42
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  42

Ser Leu Thr Ala Gln Gln Ser Ser Leu Ile Arg Glu Asp Lys Ser Asn 
1               5                   10                  15      


Ala Lys Leu Trp Asn Glu Val Leu Ala Ser Arg Pro Ala Ser Gly Ser 
            20                  25                  30          


Pro Phe Gln Leu Phe Leu Ser Lys Val Glu Glu Thr Phe Gln Cys Ile 
        35                  40                  45              


Cys Cys Gln Glu Leu Val Phe Arg Pro Ile Thr Thr Val Cys Gln His 
    50                  55                  60                  


Asn Val Cys Lys Asp Cys Leu Asp Arg Ser Phe Arg Ala Gln Val Phe 
65                  70                  75                  80  


Ser Cys Pro Ala Cys Arg Tyr Asp Leu Gly Arg Ser Tyr Ala Met Gln 
                85                  90                  95      


Val Asn Gln Pro Leu Gln Thr Val Leu Asn Gln Leu Phe Pro Gly Tyr 
            100                 105                 110         


Gly Asn Gly Arg 
        115     


<210>  43
<211>  104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  43

Ser Met Ala Leu Pro Lys Asp Ala Ile Pro Ser Leu Ser Glu Cys Gln 
1               5                   10                  15      


Cys Gly Ile Cys Met Glu Ile Leu Val Glu Pro Val Thr Leu Pro Cys 
            20                  25                  30          


Asn His Thr Leu Cys Lys Pro Cys Phe Gln Ser Thr Val Glu Lys Ala 
        35                  40                  45              


Ser Leu Cys Cys Pro Phe Cys Arg Arg Arg Val Ser Ser Trp Thr Arg 
    50                  55                  60                  


Tyr His Thr Arg Arg Asn Ser Leu Val Asn Val Glu Leu Trp Thr Ile 
65                  70                  75                  80  


Ile Gln Lys His Tyr Pro Arg Glu Cys Lys Leu Arg Ala Ser Gly Tyr 
                85                  90                  95      


Gln Pro Val Arg Leu Leu Ser Lys 
            100                 


<210>  44
<211>  82
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  44

His Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys 
1               5                   10                  15      


Phe Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys 
            20                  25                  30          


Ser Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln 
        35                  40                  45              


Arg Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu 
    50                  55                  60                  


Val Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu 
65                  70                  75                  80  


Gln Leu 
        


<210>  45
<211>  80
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  45

His Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys 
1               5                   10                  15      


Phe Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys 
            20                  25                  30          


Ser Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln 
        35                  40                  45              


Arg Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu 
    50                  55                  60                  


Val Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu 
65                  70                  75                  80  


<210>  46
<211>  82
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  46

Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe 
1               5                   10                  15      


Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser 
            20                  25                  30          


Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg 
        35                  40                  45              


Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val 
    50                  55                  60                  


Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln 
65                  70                  75                  80  


Leu Cys 
        


<210>  47
<211>  84
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  47

Met Asp Glu Gln Ser Val Glu Ser Ile Ala Glu Val Phe Arg Cys Phe 
1               5                   10                  15      


Ile Cys Met Glu Lys Leu Arg Asp Ala Arg Leu Cys Pro His Cys Ser 
            20                  25                  30          


Lys Leu Cys Cys Phe Ser Cys Ile Arg Arg Trp Leu Thr Glu Gln Arg 
        35                  40                  45              


Ala Gln Cys Pro His Cys Arg Ala Pro Leu Gln Leu Arg Glu Leu Val 
    50                  55                  60                  


Asn Cys Arg Trp Ala Glu Glu Val Thr Gln Gln Leu Asp Thr Leu Gln 
65                  70                  75                  80  


Leu Cys Ser Leu 
                


