                         SEQUENCE LISTING

<110>  CABIROL, Fabien
       GOHEL, Anupam
       LALONDE, James 
       OH, Ryan
       SMITH, Derek
       WONG, Brian

 
<120>  BIOCATALYTIC SYNTHESIS OF (S)-3-(1-AMINOETHYL)-PHENOL

<130>  CX2-051USP1

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized transaminase gene from Vibrio fluvialis

<400>  1
atgaacaaac cgcagagctg ggaagcgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgaacggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttttgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggcgtga ccgcggtgag cgcgagcatg      480

accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttgt gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtggcgcgt      600

ctggcccgtg aactggaaga aaccattcag cgtgaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcgaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gcaaaaacct gaccgcgggt ttttttccga tgggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcga gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa accccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  2
<211>  453
<212>  PRT
<213>  Vibrio fluvialis

<400>  2

Met Asn Lys Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Phe Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  3
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase transaminase

<400>  3
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggcgtga ccgcggtgag cgcgagcatg      480

accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattccgc cggcgaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcgg gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gcattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  4
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase transaminase

<400>  4

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  5
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase transaminase

<400>  5
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttatttcgc cggcgaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcgg gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  6
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase transaminase

<400>  6

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ser Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  7
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  7
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggcaaac cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cggcgaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcgg gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  8
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  8

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  9
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  9
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cggcgaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcgg gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgt gcccgccgtt tattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  10
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  10

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  11
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  11
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcgg gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  12
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  12

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  13
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  13
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaatccct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  14
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  14

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  15
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  15
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tggctttacc       60

gatatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacaa agactttggc ctgccgctgg aaggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccgcgg gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagcgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  16
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  16

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Lys Asp Phe Gly Leu Pro Leu Glu Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  17
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  17
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaatccct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  18
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  18

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  19
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  19
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgtaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtaggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  20
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  20

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  21
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  21
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgtaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  22
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  22

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  23
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  23
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgtaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccgg taggcgcggt gattctgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggcctgattt gccgtccgct gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  24
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  24

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  25
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  25
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgttg gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctgc cgatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaatccct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  26
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  26

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Ser Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  27
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  27
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgtaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  28
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  28

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  29
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  29
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggctg ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggcttta gctataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  30
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  30

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Leu Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Ser Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  31
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  31
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctacatca gcgtggcacc atggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  32
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  32

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  33
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  33
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctgcatca gcgtggcacc gtggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggctg ctgcatgcgg cggaaggcaa accgcagaaa      420

cgtaaaattc tgacccgtaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag cgtgaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattattc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggt      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaacattt tccgcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  34
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  34

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Leu Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Ile Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu His Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  35
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  35
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctacatca gcgtggcacc atggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggttt ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tgatcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  36
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  36

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Asp His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  37
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  37
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctacatca gcgtggcacc atggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgtttgtta ccaacagcgg cagcgaagcg      360

aacgaaacca tggtgaaaat gctgtggttt ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggcttcg gttataacag cgtgttcggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt tttttttccg taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggagaccgcg attgaagcga tcgaagaatt tgatcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtgtaggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  38
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  38

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Val Thr Asn Ser Gly Ser Glu Ala Asn Glu Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Gly Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Ser Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Asp His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Val Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  39
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  39
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctacatca gcgtggcacc atggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgtttgtta ccaacagcgg cagcgaagcg      360

aacgaaacca tggtgaaaat gctgtggttt ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggccatg gttataacag caaattcggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tgatcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtgtaggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  40
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  40

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Val Thr Asn Ser Gly Ser Glu Ala Asn Glu Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly His Gly Tyr Asn Ser Lys Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Asp His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Val Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  41
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  41
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctacatca gcgtggcacc atggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgttttata ccaacagcgg cagcgaagcg      360

aacgatacca tggtgaaaat gctgtggatg ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggctttc cgtataacag cgtgtttggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tgatcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgattgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggc gaatatcgtg gtattggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gggccagagc     1260

gtggttctgg caccgccgta cattctgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  42
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  42

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Met Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Phe Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Asp His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  43
<211>  1362
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  43
atgaacaaac cgcagagctg ggaaacgcgt gcggaaacct atagcctgta tgcctttacc       60

cacatgccga gcctacatca gcgtggcacc atggtggtga cccatggcga aggcccgtat      120

atcgtggatg tgcatggccg tcgttatctg gatgcgaaca gcggcctgtg gaacatggtg      180

gcgggctttg atcataaagg cctgattgat gcggcgaaag cgcagtatga acgttttccg      240

ggctatcatg cgttttacgg ccgtatgagc gatcagaccg tgatgctgtc tgaaaaactg      300

gtggaagtga gcccgtttga tagcggccgt gtgtttgtta ccaacagcgg cagcgaagcg      360

aacgaaacca tggtgaaaat gctgtggttt ctgcatcgtg cggaaggcaa accgcagaaa      420

cgtaaaattc tgaccctgaa gaacgcgtat catggctcca ccgcggtgag cgcgagcatg      480

accggccatg gttataacag caaattcggc ctgccgctgc cgggctttct gcatctgacc      540

tgcccgcatt attggcgtta tggcgaagaa ggcgaaaccg aagaacagtt tgtcgcgcgt      600

ctggcccgtg aactggaaga aaccattcag aaggaaggcg cggataccat tgcgggcttt      660

tttgcggaac cggtgatggg tgcgggcggt gttattaccc cgccaaaagg ctattttcag      720

gcgattctga ccatcctgcg caaatatgat attccggtga tcagcgatga agtgatttgc      780

ggctttggcc gtaccggcaa cacctggggc tgcgtgacct atgattttac cccggatgcg      840

attattagca gtaaaaacct aaccgcgggt ttttttccag taggagcggt gattttgggg      900

ccggaactga gcaaacgtct ggaaaccgcg attgaagcga tcgaagaatt tgatcatggt      960

tttaccacag gcggccatcc ggtgggttgt gcgactgcgc tgaaagcgat tgatgtggtg     1020

atgaacgaag gcctggccga aaacgtgcgt cgtctggccc cgcgttttga agaacgtctg     1080

aaacatattg cggaacgtcc gaacattggt gaatatcgtg gtgtaggctt tatgtgggcg     1140

ctggaagtgg tgaaagataa agcgagcaaa gccccgtttg atggcaacct gagcgtgagc     1200

gaacgtattg cgaacacctg caccgatctg ggactgattt gccgaccgtt gcaacagagc     1260

gtggttctgg caccgccgta catactgacc gaagcgcaga tggatgaaat gttcgataaa     1320

ctggaaaaag cgctggataa agtgtttgcg gaagtggcgt aa                        1362


<210>  44
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of Vibrio fluvialis transaminase

<400>  44

Met Asn Lys Pro Gln Ser Trp Glu Thr Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Ala Phe Thr His Met Pro Ser Leu His Gln Arg Gly Thr Met Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val His Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Tyr Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Val Thr Asn Ser Gly Ser Glu Ala Asn Glu Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Arg Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Leu Lys Asn Ala Tyr His Gly Ser Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly His Gly Tyr Asn Ser Lys Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Leu His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Lys Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Thr Pro Pro Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Thr Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Val Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Asp His Gly 
305                 310                 315                 320 


Phe Thr Thr Gly Gly His Pro Val Gly Cys Ala Thr Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Val Gly Phe Met Trp Ala Leu Glu Val Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Ala Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gln Gln Ser Val Val Leu Ala Pro Pro Tyr Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


