                         SEQUENCE LISTING

<110>  University of Pennsylvania
       Chatterjee, Manash
       Purvis, Jeremy
       Diamond, Scott
 
<120>  Methods for Predicting Cellular Signaling Responses to 
       Combinatorial Stimuli

<130>  46483-5196-00-WO (600919)

<150>  61/355,842
<151>  2010-06-17

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  158
<212>  PRT
<213>  Crotalus durissus


<220>
<221>  misc_feature
<223>  alpha subnit

<400>  1

Met Gly Arg Phe Ile Phe Val Ser Phe Gly Leu Leu Val Leu Phe Leu 
1               5                   10                  15      


Ser Leu Ser Gly Thr Gly Ala Gly Leu His Cys Pro Ser Asp Trp Tyr 
            20                  25                  30          


Tyr Tyr Asp Gln His Cys Tyr Arg Ile Phe Asn Glu Glu Met Asn Trp 
        35                  40                  45              


Glu Asp Ala Glu Trp Phe Cys Thr Lys Gln Ala Lys Gly Ala His Leu 
    50                  55                  60                  


Val Ser Ile Lys Ser Ala Lys Glu Ala Asp Phe Val Ala Trp Met Val 
65                  70                  75                  80  


Thr Gln Asn Ile Glu Glu Ser Phe Ser His Val Ser Ile Gly Leu Arg 
                85                  90                  95      


Val Gln Asn Lys Glu Lys Gln Cys Ser Thr Lys Trp Ser Asp Gly Ser 
            100                 105                 110         


Ser Val Ser Tyr Asp Asn Leu Leu Asp Leu Tyr Ile Thr Lys Cys Ser 
        115                 120                 125             


Leu Leu Lys Lys Glu Thr Gly Phe Arg Lys Trp Phe Val Ala Ser Cys 
    130                 135                 140                 


Ile Gly Lys Ile Pro Phe Val Cys Lys Phe Pro Pro Gln Cys 
145                 150                 155             


<210>  2
<211>  148
<212>  PRT
<213>  Crotalus durissus


<220>
<221>  MISC_FEATURE
<223>  beat subunit

<400>  2

Met Gly Arg Phe Ile Phe Val Ser Phe Gly Leu Leu Val Val Phe Leu 
1               5                   10                  15      


Ser Leu Ser Gly Ser Glu Ala Gly Phe Cys Cys Pro Ser His Trp Ser 
            20                  25                  30          


Ser Tyr Asp Arg Tyr Cys Tyr Lys Val Phe Lys Gln Glu Met Thr Trp 
        35                  40                  45              


Ala Asp Ala Glu Lys Phe Cys Thr Gln Gln His Thr Gly Ser His Leu 
    50                  55                  60                  


Val Ser Phe His Ser Thr Glu Glu Val Asp Phe Val Val Lys Met Thr 
65                  70                  75                  80  


His Gln Ser Leu Lys Ser Thr Phe Phe Trp Ile Gly Ala Asn Asn Ile 
                85                  90                  95      


Trp Asn Lys Cys Asn Trp Gln Trp Ser Asp Gly Thr Lys Pro Glu Tyr 
            100                 105                 110         


Lys Glu Trp His Glu Glu Phe Glu Cys Leu Ile Ser Arg Thr Phe Asp 
        115                 120                 125             


Asn Gln Trp Leu Ser Ala Pro Cys Ser Asp Thr Tyr Ser Phe Val Cys 
    130                 135                 140                 


Lys Phe Glu Ala 
145             


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  3

Ser Phe Leu Leu Arg Asn 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  4

Ala Tyr Pro Gly Lys Phe 
1               5       


<210>  5
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  6

Gly Gly Ala Cys Lys 
1               5   


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chemically synthesized

<400>  7

Gly Pro Arg Pro 
1               


