
                                SEQUENCE LISTING

<110> Klaenhammer, Todd R.
     	Pfeiler, Erika
	Mohamadzadeh, Mansour

<120> Compositions and Methods to Reduce
  Inflammatory Responses

<130> 35051/406734

<150>  US 61/356,165
<151>  2010-06-18

<150>  US 61/433,598
<151>  2011-01-18

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1161
<212> DNA
<213> Lactobacillus acidophilius

<220> 
<221> misc_feature   
<222> (1)...(1161)
<223> LBA0444 Glycosyltransferase
      GenBank Accession No. AAV42334
      

<220> 
<221> CDS            
<222> (1)...(1161)

<400> 1
atg aat att ggt ctt tat acc gat aca tat ttt ccc caa ata agt ggc   48
Met Asn Ile Gly Leu Tyr Thr Asp Thr Tyr Phe Pro Gln Ile Ser Gly
 1               5                   10                  15
 
gta gct act tct att agg acg cta aaa gat gcg ctt gaa aga cag ggg   96
Val Ala Thr Ser Ile Arg Thr Leu Lys Asp Ala Leu Glu Arg Gln Gly
             20                  25                  30
 
cat aat gta ttt att ttt aca act aca gat cca aat gta gaa aag ggc   144
His Asn Val Phe Ile Phe Thr Thr Thr Asp Pro Asn Val Glu Lys Gly
         35                  40                  45
 
act gtt gag cca aat gtt ttt cgt ttt agc agt ata cct ttt gtt tca   192
Thr Val Glu Pro Asn Val Phe Arg Phe Ser Ser Ile Pro Phe Val Ser
     50                  55                  60
 
ttc aca gat cgt aga att gca ttt aga ggc tta ttt gaa gca act aag   240
Phe Thr Asp Arg Arg Ile Ala Phe Arg Gly Leu Phe Glu Ala Thr Lys
 65                  70                  75                  80
 
gta gct aag gaa gta aat ttg gat att gta cat aca caa act gaa ttt   288
Val Ala Lys Glu Val Asn Leu Asp Ile Val His Thr Gln Thr Glu Phe
                 85                  90                  95
 
gct tta ggt aca att ggc aaa tat gta gcc cac caa tta gat att cct   336
Ala Leu Gly Thr Ile Gly Lys Tyr Val Ala His Gln Leu Asp Ile Pro
            100                 105                 110
 
gca att cat act tat cac aca atg tat gaa gat tat ttg cat tat att   384
Ala Ile His Thr Tyr His Thr Met Tyr Glu Asp Tyr Leu His Tyr Ile
        115                 120                 125
 
tta aat ggt cac tta ttg cga cca tat cat gtt aaa caa ttc gta aaa   432
Leu Asn Gly His Leu Leu Arg Pro Tyr His Val Lys Gln Phe Val Lys
    130                 135                 140
 
agc tat tta aaa aat atg gat ggc tgt att gcc cca agt gga cgt gta   480
Ser Tyr Leu Lys Asn Met Asp Gly Cys Ile Ala Pro Ser Gly Arg Val
145                 150                 155                 160
 
gaa gat ttg tta aag cga tat ggc gtg caa att cca att agg gta att   528
Glu Asp Leu Leu Lys Arg Tyr Gly Val Gln Ile Pro Ile Arg Val Ile
                165                 170                 175
 
cct act gga gta gat ttg cag gga atg aat ggc gat gct gaa cgt gat   576
Pro Thr Gly Val Asp Leu Gln Gly Met Asn Gly Asp Ala Glu Arg Asp
            180                 185                 190
 
gta cgt cag gaa tta gga atc gac aaa gat gct cct gta att tta act   624
Val Arg Gln Glu Leu Gly Ile Asp Lys Asp Ala Pro Val Ile Leu Thr
        195                 200                 205
 
tta agt aga att gca gca gaa aag aaa ata aat cat att ctt aat gtg   672
Leu Ser Arg Ile Ala Ala Glu Lys Lys Ile Asn His Ile Leu Asn Val
    210                 215                 220
 
atg cca gca att gta gaa gaa ttt cca aat att aaa ttt gta att gcc   720
Met Pro Ala Ile Val Glu Glu Phe Pro Asn Ile Lys Phe Val Ile Ala
225                 230                 235                 240
 
ggt gat gga cct gat gtt aaa gtg ctg aaa gaa caa gtt gaa cgt tta   768
Gly Asp Gly Pro Asp Val Lys Val Leu Lys Glu Gln Val Glu Arg Leu
                245                 250                 255
 
act tta gaa gat tat gtt tta ttt gtc ggt aac gtt gat cat gga gat   816
Thr Leu Glu Asp Tyr Val Leu Phe Val Gly Asn Val Asp His Gly Asp
            260                 265                 270
 
gta ggc aat tat tat cga atg gcc gat ctt ttt gtt tct gcc agt gac   864
Val Gly Asn Tyr Tyr Arg Met Ala Asp Leu Phe Val Ser Ala Ser Asp
        275                 280                 285
 
act gaa acc caa ggt ctt act tat ata gaa gct ttg gct gca ggt aca   912
Thr Glu Thr Gln Gly Leu Thr Tyr Ile Glu Ala Leu Ala Ala Gly Thr
    290                 295                 300
 
cca tgt gta gtt tac gac act gat tac act gaa aat att ttt gat aat   960
Pro Cys Val Val Tyr Asp Thr Asp Tyr Thr Glu Asn Ile Phe Asp Asn
305                 310                 315                 320
 
gat gtc ttt gga cgt act ttt gtt aca cag aag gaa atg ttg caa gaa   1008
Asp Val Phe Gly Arg Thr Phe Val Thr Gln Lys Glu Met Leu Gln Glu
                325                 330                 335
 
att att gaa tta ttg aaa aaa gga cac aat aga att cca caa gat ctt   1056
Ile Ile Glu Leu Leu Lys Lys Gly His Asn Arg Ile Pro Gln Asp Leu
            340                 345                 350
 
tta caa aat aaa ttg cag aag att tca tcg gag caa ttt gct aca aat   1104
Leu Gln Asn Lys Leu Gln Lys Ile Ser Ser Glu Gln Phe Ala Thr Asn
        355                 360                 365
 
gtc cat gat ttt tat aaa tac gcg att gat cat tat caa cct aaa cat   1152
Val His Asp Phe Tyr Lys Tyr Ala Ile Asp His Tyr Gln Pro Lys His
    370                 375                 380
 
gaa gaa ata                                                       1161
Glu Glu Ile
385
 

<210> 2
<211> 387
<212> PRT
<213> Lactobacillus acidophilius

<400> 2
Met Asn Ile Gly Leu Tyr Thr Asp Thr Tyr Phe Pro Gln Ile Ser Gly
 1               5                  10                  15      
Val Ala Thr Ser Ile Arg Thr Leu Lys Asp Ala Leu Glu Arg Gln Gly
            20                  25                  30          
His Asn Val Phe Ile Phe Thr Thr Thr Asp Pro Asn Val Glu Lys Gly
        35                  40                  45              
Thr Val Glu Pro Asn Val Phe Arg Phe Ser Ser Ile Pro Phe Val Ser
    50                  55                  60                  
Phe Thr Asp Arg Arg Ile Ala Phe Arg Gly Leu Phe Glu Ala Thr Lys
65                  70                  75                  80  
Val Ala Lys Glu Val Asn Leu Asp Ile Val His Thr Gln Thr Glu Phe
                85                  90                  95      
Ala Leu Gly Thr Ile Gly Lys Tyr Val Ala His Gln Leu Asp Ile Pro
            100                 105                 110         
Ala Ile His Thr Tyr His Thr Met Tyr Glu Asp Tyr Leu His Tyr Ile
        115                 120                 125             
Leu Asn Gly His Leu Leu Arg Pro Tyr His Val Lys Gln Phe Val Lys
    130                 135                 140                 
Ser Tyr Leu Lys Asn Met Asp Gly Cys Ile Ala Pro Ser Gly Arg Val
145                 150                 155                 160 
Glu Asp Leu Leu Lys Arg Tyr Gly Val Gln Ile Pro Ile Arg Val Ile
                165                 170                 175     
Pro Thr Gly Val Asp Leu Gln Gly Met Asn Gly Asp Ala Glu Arg Asp
            180                 185                 190         
Val Arg Gln Glu Leu Gly Ile Asp Lys Asp Ala Pro Val Ile Leu Thr
        195                 200                 205             
Leu Ser Arg Ile Ala Ala Glu Lys Lys Ile Asn His Ile Leu Asn Val
    210                 215                 220                 
Met Pro Ala Ile Val Glu Glu Phe Pro Asn Ile Lys Phe Val Ile Ala
225                 230                 235                 240 
Gly Asp Gly Pro Asp Val Lys Val Leu Lys Glu Gln Val Glu Arg Leu
                245                 250                 255     
Thr Leu Glu Asp Tyr Val Leu Phe Val Gly Asn Val Asp His Gly Asp
            260                 265                 270         
Val Gly Asn Tyr Tyr Arg Met Ala Asp Leu Phe Val Ser Ala Ser Asp
        275                 280                 285             
Thr Glu Thr Gln Gly Leu Thr Tyr Ile Glu Ala Leu Ala Ala Gly Thr
    290                 295                 300                 
Pro Cys Val Val Tyr Asp Thr Asp Tyr Thr Glu Asn Ile Phe Asp Asn
305                 310                 315                 320 
Asp Val Phe Gly Arg Thr Phe Val Thr Gln Lys Glu Met Leu Gln Glu
                325                 330                 335     
Ile Ile Glu Leu Leu Lys Lys Gly His Asn Arg Ile Pro Gln Asp Leu
            340                 345                 350         
Leu Gln Asn Lys Leu Gln Lys Ile Ser Ser Glu Gln Phe Ala Thr Asn
        355                 360                 365             
Val His Asp Phe Tyr Lys Tyr Ala Ile Asp His Tyr Gln Pro Lys His
    370                 375                 380                 
Glu Glu Ile
385         


<210> 3
<211> 1041
<212> DNA
<213> Lactobacillius acidophilus

<220> 
<221> misc_feature   
<222> (1)...(1041)
<223> LBA0445  Glycosyltransferase
      GenBank Accession No. AAV42335
      

<220> 
<221> CDS            
<222> (1)...(1041)

<400> 3
atg att aga att aat atg ttc tca caa gct gat tca gtt aaa ggt caa   48
Met Ile Arg Ile Asn Met Phe Ser Gln Ala Asp Ser Val Lys Gly Gln
 1               5                   10                  15
 
gga gtg ggc tca gcc tac aat gaa ttg atc aaa tta ttg aga acc cgc   96
Gly Val Gly Ser Ala Tyr Asn Glu Leu Ile Lys Leu Leu Arg Thr Arg
             20                  25                  30
 
tta gta gat gag ttt tat gta aca att aat aga tat ggt aat agt gat   144
Leu Val Asp Glu Phe Tyr Val Thr Ile Asn Arg Tyr Gly Asn Ser Asp
         35                  40                  45
 
tta acg cac tat cat aca att aat cca act tat ttc gta aat agt ttt   192
Leu Thr His Tyr His Thr Ile Asn Pro Thr Tyr Phe Val Asn Ser Phe
     50                  55                  60
 
tca cct gct cgt gga aga aaa ata gga tat gtt cac ttt ttg cct gat   240
Ser Pro Ala Arg Gly Arg Lys Ile Gly Tyr Val His Phe Leu Pro Asp
 65                  70                  75                  80
 
aca tta gat gga tcg ctt aag ttg ccg gga ata gct aaa aat gtg gtt   288
Thr Leu Asp Gly Ser Leu Lys Leu Pro Gly Ile Ala Lys Asn Val Val
                 85                  90                  95
 
tat gat tac gtg att gat ttt tat aag cga atg gat caa atc gta gtt   336
Tyr Asp Tyr Val Ile Asp Phe Tyr Lys Arg Met Asp Gln Ile Val Val
            100                 105                 110
 
gta aat cca att ttt att gat aaa ttg gtt gat tat ggc att gaa cgc   384
Val Asn Pro Ile Phe Ile Asp Lys Leu Val Asp Tyr Gly Ile Glu Arg
        115                 120                 125
 
gat agg gtt aaa tac att cct aat ttt gtt tct aaa gaa gaa ttt tat   432
Asp Arg Val Lys Tyr Ile Pro Asn Phe Val Ser Lys Glu Glu Phe Tyr
    130                 135                 140
 
gaa gaa tca ttg gca agt aag aat gcc ttt cga cat gaa tta aag att   480
Glu Glu Ser Leu Ala Ser Lys Asn Ala Phe Arg His Glu Leu Lys Ile
145                 150                 155                 160
 
cca ctt gat aag ttt gtt gtt ttt ggt gat gga caa gtt caa gaa cgt   528
Pro Leu Asp Lys Phe Val Val Phe Gly Asp Gly Gln Val Gln Glu Arg
                165                 170                 175
 
aaa gga att gat gat ttt gta aaa atg gct aaa gct aat cca gat gtt   576
Lys Gly Ile Asp Asp Phe Val Lys Met Ala Lys Ala Asn Pro Asp Val
            180                 185                 190
 
cag ttt att tgg gct ggt gga ttt tcg ttt ggc aaa att aca gat gga   624
Gln Phe Ile Trp Ala Gly Gly Phe Ser Phe Gly Lys Ile Thr Asp Gly
        195                 200                 205
 
tat aat cac tat aaa gaa atg gtg gat aat cca cct gaa aat ttg att   672
Tyr Asn His Tyr Lys Glu Met Val Asp Asn Pro Pro Glu Asn Leu Ile
    210                 215                 220
 
ttt aca gga atc gta gat cgt aca aaa tta gtt aag tat ttg aat att   720
Phe Thr Gly Ile Val Asp Arg Thr Lys Leu Val Lys Tyr Leu Asn Ile
225                 230                 235                 240
 
gct gat tta ttt gtt tta cca tca tac gat gaa cta ttc cca atg tct   768
Ala Asp Leu Phe Val Leu Pro Ser Tyr Asp Glu Leu Phe Pro Met Ser
                245                 250                 255
 
gtt ctt gaa gcg ttt agt tgt ggg aca cca gtg ctt ttg cgc gat ctt   816
Val Leu Glu Ala Phe Ser Cys Gly Thr Pro Val Leu Leu Arg Asp Leu
            260                 265                 270
 
gac tta tat aag gca att att gat ggc tat tat atg agt gga aaa gac   864
Asp Leu Tyr Lys Ala Ile Ile Asp Gly Tyr Tyr Met Ser Gly Lys Asp
        275                 280                 285
 
ttt agt gaa atg aat caa att ttg caa aac gta att aaa aat cca caa   912
Phe Ser Glu Met Asn Gln Ile Leu Gln Asn Val Ile Lys Asn Pro Gln
    290                 295                 300
 
tta ttg aaa aaa tat agt gat tta tcg ttg aag gcc agc caa gaa tat   960
Leu Leu Lys Lys Tyr Ser Asp Leu Ser Leu Lys Ala Ser Gln Glu Tyr
305                 310                 315                 320
 
tca gaa gaa cga tta gct aaa att tgg aat gaa ttt tat cat gag caa   1008
Ser Glu Glu Arg Leu Ala Lys Ile Trp Asn Glu Phe Tyr His Glu Gln
                325                 330                 335
 
tat aaa ttg ggc aaa gaa cta gga caa att cat                       1041
Tyr Lys Leu Gly Lys Glu Leu Gly Gln Ile His
            340                 345
 

<210> 4
<211> 347
<212> PRT
<213> Lactobacillius acidophilus

<400> 4
Met Ile Arg Ile Asn Met Phe Ser Gln Ala Asp Ser Val Lys Gly Gln
 1               5                  10                  15      
Gly Val Gly Ser Ala Tyr Asn Glu Leu Ile Lys Leu Leu Arg Thr Arg
            20                  25                  30          
Leu Val Asp Glu Phe Tyr Val Thr Ile Asn Arg Tyr Gly Asn Ser Asp
        35                  40                  45              
Leu Thr His Tyr His Thr Ile Asn Pro Thr Tyr Phe Val Asn Ser Phe
    50                  55                  60                  
Ser Pro Ala Arg Gly Arg Lys Ile Gly Tyr Val His Phe Leu Pro Asp
65                  70                  75                  80  
Thr Leu Asp Gly Ser Leu Lys Leu Pro Gly Ile Ala Lys Asn Val Val
                85                  90                  95      
Tyr Asp Tyr Val Ile Asp Phe Tyr Lys Arg Met Asp Gln Ile Val Val
            100                 105                 110         
Val Asn Pro Ile Phe Ile Asp Lys Leu Val Asp Tyr Gly Ile Glu Arg
        115                 120                 125             
Asp Arg Val Lys Tyr Ile Pro Asn Phe Val Ser Lys Glu Glu Phe Tyr
    130                 135                 140                 
Glu Glu Ser Leu Ala Ser Lys Asn Ala Phe Arg His Glu Leu Lys Ile
145                 150                 155                 160 
Pro Leu Asp Lys Phe Val Val Phe Gly Asp Gly Gln Val Gln Glu Arg
                165                 170                 175     
Lys Gly Ile Asp Asp Phe Val Lys Met Ala Lys Ala Asn Pro Asp Val
            180                 185                 190         
Gln Phe Ile Trp Ala Gly Gly Phe Ser Phe Gly Lys Ile Thr Asp Gly
        195                 200                 205             
Tyr Asn His Tyr Lys Glu Met Val Asp Asn Pro Pro Glu Asn Leu Ile
    210                 215                 220                 
Phe Thr Gly Ile Val Asp Arg Thr Lys Leu Val Lys Tyr Leu Asn Ile
225                 230                 235                 240 
Ala Asp Leu Phe Val Leu Pro Ser Tyr Asp Glu Leu Phe Pro Met Ser
                245                 250                 255     
Val Leu Glu Ala Phe Ser Cys Gly Thr Pro Val Leu Leu Arg Asp Leu
            260                 265                 270         
Asp Leu Tyr Lys Ala Ile Ile Asp Gly Tyr Tyr Met Ser Gly Lys Asp
        275                 280                 285             
Phe Ser Glu Met Asn Gln Ile Leu Gln Asn Val Ile Lys Asn Pro Gln
    290                 295                 300                 
Leu Leu Lys Lys Tyr Ser Asp Leu Ser Leu Lys Ala Ser Gln Glu Tyr
305                 310                 315                 320 
Ser Glu Glu Arg Leu Ala Lys Ile Trp Asn Glu Phe Tyr His Glu Gln
                325                 330                 335     
Tyr Lys Leu Gly Lys Glu Leu Gly Gln Ile His
            340                 345         

