                         SEQUENCE LISTING

<110>  Kymab Limited
 
<120>  Animal models and therapeutic molecules

<130>  P/25077.8

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  4272
<212>  DNA
<213>  Rattus norvegicus

<400>  1
agatctgccc atctcaggct agttaaatta gttcatccca gtttggccca acttacccca       60

tctagagtag cgaaactaat ctgagcctag ctaagtccag tttagtttaa tgtagcccag      120

cttggcacag gctaatacat actgctacag tttggtctag cctaccctaa ttaagctgat      180

ccaggcctgg gtagacctag ctcatctcag cccagttaag gttatccagt acatctcttt      240

ccagttcagc tcaggttacc ataccttatc tcaattcagc tcagctagtg taattcatct      300

tagttcatcc cctacccctc tagactccct gttgatctta actcagttta gacatggcca      360

acaaagcctg gcccaactca ggccaggtta gtgtagctca gcataagcag tctagccttg      420

ctcagtctag ctcacccttc ctcatctaaa ttcaactcag ctatgccggc cctgcagcag      480

gtcccctcag ctcacccaag tccaaccagt tcagtctggc tcatttaagt cttgacaatc      540

cccaattcat cccagctcag cttagcataa ctcaggcagt ccattcttag cccaacccag      600

tttagcccag tttatcccag ttcatcctgg ctgtactcag tgcaactcga ttcatgttct      660

cccaggccac ctcagcccag ttcatggtag ctcatctgag cccaacttat cccagctcat      720

cccaaaccac ctcacctaag ccctgctcag cctagctcat ctgagcctag ttcaacctct      780

ctcatcctgc cagctagccc agtttagtcc acatcatctt gcaaagctca accagcccaa      840

gtcagccggg tccagctcat tcatgtccaa accagctcag tcatgctcat cctaactcag      900

cctcaccatc atccacatca gctagcccag ttcagctgag ctcatcccag cccacttcaa      960

tcacagctca tttaagtaca gctcacccca gctctattta gctcaagcta gcttatttag     1020

cctacttcat cccagctcag cccagccaac tcaactcatc ctagctcagc taaaccctgc     1080

tcagctcacc caagcaaagc tgactccaac ccagatcctt tcagctcagc tcacccagct     1140

caggccagct cacccatccc agctcaccca gcttagctca cccagcccag ctcagcccag     1200

ctcacccagc ccagctcagc ccagctcacc cagcccagct cagcccagct cagctcagct     1260

cagctcagct cagctcagct cacccagctc agctcagcca gctcagctca ccccagctca     1320

gtccagctca gttcagctca ccccagctca gctcacccaa ctcagctcac tcaactcagc     1380

tcacccaact cagctcagct cagttcaccc agctcagctc acccagccca gcacagctca     1440

tctcacccag ctcagctcac ccagcccagc tcaccccagc tcaccccagc tcagctcagc     1500

tcaccccagc tcagcccagc tcagctcacc cagctcagct cacccaactc agctcagctc     1560

agttcaccca gctcagctca cccagcccag cacagctcat ctcacccagc ccagctcacc     1620

ccagctcacc ccagctcagc tcagctcagc ccagctcacc cagctcagct cagctcaccc     1680

cagctcagct cacccagctc agctcaccca gcccagctca gctcagctca ccccagctca     1740

gcccagctca gctcacccag ctcagctcac ccagcccagc tcaccccagc tcaccccagc     1800

tcagtccagc tcagttcagc tcacccagct cagctcaccc aactcaactc agctcagttc     1860

acccagctca gctcagctca ccccagctca ccccagctca cccagctcag ttcagctcac     1920

cccagctcag ttcacccagc tcagctcacc cagcccagct cagcccagct caccccagct     1980

cagctcaacc agatcagctc agcccagctc accctagttt agttcaccca gcccagctca     2040

ccccagctca gctcacccca actcagctca cccagctcat cccagctcag ccagctaatc     2100

ccagctcagc tcaccccagc tcagctcacc cagctcagct cacccaactc agctcacccc     2160

agctcacccc agctcatccc agctcatccc agttcagacc tgttcagctc atctcacccc     2220

agctcagctc accccagttc agctcaccta gcccaactca ccccagctca gtccagctca     2280

gttcagctca ccccaactca tctcacccag ctcagctcac cccagctcat cccagctcag     2340

ctcaccccag ttcagccctg ttcagctcat ctcacccagc tcagctcatc cagcccagct     2400

caccccagct caccccagct cagtccagct cagttcagct cacccagctc agctcaccca     2460

actcaactca gctcagttca cccagctcag ctcagctcac cccagctcac ccagctcagt     2520

tcagctcacc ccagctcagt tcacccagct cagctcaccc agcccagctc aaccagatca     2580

gctcagccca gctcacccta gtttagttca cccagcccag ctcaccccag ctcagctcac     2640

cccaactcag ctcacctagc tcatcccagc tcagctcacc ccagctcagc tcaccccagc     2700

tcatctcacc ccagctcagc tcacccagct catcccagct cagctcagcc cagctcatcc     2760

cagccctgct catcccagct cagctcagct cagcccagct cagcccagct cagcccagct     2820

cagcccagct cagcccagct cagctcaacc cagctcagct cacccagccc agctcagccc     2880

agctcaccca gctcagctca ccccagctca gctcacccca gctcatctca cccagctcag     2940

ctcacccagc tcagcccagc tcagctcagc tcacccagct catctcaccc agctcagctc     3000

accccagctc atcccagctc agctcacccc agttcagccc tgttcagctc atctcacccc     3060

agctcagctc acccagttca gctcatccca gcccatccca gctcagctca gcccagctca     3120

gcccagctca gcccagccca gcccagccca gctcagctca gcccagctca gcccagctca     3180

gtccagctca gcttagccca gcccagctca gctcagccca gctcagccca gctcagccca     3240

gctcagctca cccagctcac cccagctcag cccagctcag cccagctcag ctcacccagc     3300

tcaccccacc ccagctcacc ccagttcagc ccagctcagc ccagctcagc ccagcccagc     3360

ccagcccagc ccagcccagc tcagcccagc tcagctcagc ccagcccagc tcagctcagc     3420

ccagctcagc ccagctcatc ccagctcagc tcaccccagc tcagcccagc tcagcccagc     3480

tcagctcacc cagctcaccc caccccagct caccccagtt cagcccagct catccagctc     3540

agctcacccc cagctctgct cacccagctc agctcagctt acccagctca gctcaactca     3600

cccagctcag ctcacccagc tcagctcagc tcaccccagc ccagctcagc tcagctcacc     3660

ccagctctgc tcacccagct cagctcagct cacctcagct ctgctcaccc agctcagctc     3720

aaccacctca ggtcagccca gctcacccca gcttacccca gctcacccag ctcagctcag     3780

ctcacccagc tcagctcacc cagctcagct caccccagct taccccagct caccccagct     3840

cagctaaccc agctcagctc acccagctca gctcacccag ctcagctcat cccagctcac     3900

cccagctacc acagagtagc tcatgctagc tcagctcacc ccagcacaac acagcccaac     3960

acagctcagt tcagagcagt ccagtagagt ttagctccaa tcagcccaga tcaagacaat     4020

tcattccaat ttggctatct tggttaagtc agcctagttt agcttagccg gcctagctca     4080

attcagctca ttgcagtcta cctcgttcct gctcaagtcc agctttggct acctcagagt     4140

aatcatctca gcttagcaca tttttgaagg gctcagggaa gcctacacat ctcagtccaa     4200

ctgtgcttaa ctagagccta gcttcctagc caggctgtca accttgttca ctaaattttg     4260

ctcagcaagc tt                                                         4272


<210>  2
<211>  22190
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tragetting Vector (long version)

<400>  2
gcggccgcaa cctgggcaaa tgggagctta gcaacaatgt agggggctgg acctagactt       60

cctacacatt tgtagcagat gtgcagcttg gtcttcatgt gtgtattacc ctaacatttg      120

gagcaggagc tgtctctgac tctgttgcct gccattggat ccccttcccc tgcttgggct      180

gccttgtttg gccttagtag gaaaggatgt gcttagtcct gctgtgactt gatgtcccta      240

ggcagaatga taccccaggg gggctcccca tctctgagga gatgggcaaa gggtaatggt      300

tggagggact tgtgaggctg ggactgggag gagagaaagg agacagctgt aactggaatg      360

atgttaagtg aacaaatgaa tggatagatt agatagacag atagacagac agacagacag      420

acagacagac agacagacag acagatagaa agatagatag ataaggggaa aaagaaacgt      480

agctgagcaa gccagagaga gcaagccaaa taagcagcat tcctccatga cttttccttc      540

agctcctgcc tatgagtctg ccttgacttc cctcagtgat tggttgtaag ttaaaaggtg      600

aaataaaccc tttctttgac aagttgcttt tggttctgat ttttatcaca gcaagagaaa      660

atcaaactag aacaaacatg tatttttcct ggcacatgtc catagtaagg cagaaatgat      720

cttcagacct agaccataga tactacagag agcagaagtg tagataggtg gacttactgt      780

atgattgtaa tccaagtaaa tctacatagc tagagagcta gaggaaaggc caaagcttcc      840

tctgggaggt cagatcctgt cgcactgtag ccaataaggc atattgcatc acaggaaagg      900

actaagaccc aggctggcaa tagtgtctgt atcttaacta gacctctcta gtgagtgagg      960

aaggaagttt gtgagagccc agactgtggg ctcggaaggt acctgccatg cccctgttag     1020

taactgagta ctacagcagg agcaggtgtt ctctagaaag cctgagacaa ctctacttct     1080

tctctcaaga gaccacctaa tacaggcctg agagaacaga ctctggaaat agatgggact     1140

taaggagcta agatctagag ctcatctaca gagcagaatc ccagccaaga gaacaaagaa     1200

tactggctct ctctcctgtt ccctactcct agagttctaa aacacactat agggaaggga     1260

gcctctagac ctccgtccat tccccatctt gctcattcca tcttcccatg tccccaggtc     1320

tccaagccac agacactacc tttcctattc acccaccttt ctgtgtccct aggtccccag     1380

gccatagtca cctcccccca cacacacccc actcaccctg ccccatctat gcccctagat     1440

gcttacttac cagagtcttt tgtctgacgt ggggctacaa gcatctatgc tccctaagca     1500

cctactgctg acctgtagga cccagctctg aaccaactca tataagtaaa tacagactct     1560

cccctgtctt aggatggcct cctggatcag gaggagacca ctgccaaaga accttctctc     1620

agagcactga actcctcccc tgtaccactt aggacagacc tgagacctat tattactgat     1680

taccagagct ctggcagtga ccacggagga gataggtcca ccctggacac aggaaacaca     1740

gcagcagaga tactgctcca tcacaacagt agagtgacac tttagacttt aatttgggtc     1800

actttcctgc tgcagaggtg ggatcagaaa gcaaagagca gtatgagtgc ctgataggca     1860

cccaagtaca ctatagagta ctcatggtga ataaggtacc tccatggctt cccagggagg     1920

ggcactgccc cacccccacc atcacagacc tttctccata gttgataact cagacacaag     1980

tgaatgacag atggacctcc atctactctt attttaaaaa gaagacaaac cccacaggct     2040

cgagaacttt agcgactgtt ttgagagaaa tcattggtcc ctgactcaag agatgactgg     2100

cagattgggg atcagaatac ccatactctg tggctagtgt gaggtttaag cctcagagtc     2160

cctgtggtct ctgactggtg caaggttttg actaagcgga gcaccacagt gctaactggg     2220

accacggtga cacgtggctc aacaaaaacc ttctgtttgg agctctccag gggcagcctg     2280

agctatgagg aagtagagag gcttgagaaa tctgaggaag aaaagagtag atctgagagg     2340

aaaggtagct ttctggaggt caggagacag tgcagagaag aacgagttac tgtggacagg     2400

tcttagatgg ggaaagaatg agcaaatgca agcatcagaa gggtggatgc aatgtcctgc     2460

caaggactta ccaagaggat ccccggacag agcaggcagg tggagttgac tgagaggaca     2520

gggtaggtgc aggtccctct ctcgtttcct ttctccttct cctgtttcct tcctctcttg     2580

tcacaggtct cactatgcta gccaaggcta gcctgaaaga ttaccatcct acagatgggc     2640

ccatccagtt gagttaaggt ggagatctct ccaaacatct gagtttctga ggcttggatg     2700

ccactgggga cgccaaggga ctttgggctg ggtttggttg gccccagatg aagggctact     2760

tcactgggtc tataattact ctgatgtcta ggaccagggg gctcaggtca ctcaggtcag     2820

gtgagtcctg catctgggga ctgtggggtt caggtgtcct aaggcaggat gtggagagag     2880

ttttagtata ggaacagagg cagaacagag actgtgctac tggtacttcg atgtctgggg     2940

cgcagggacc acggtcaccg tctcctcagg taagctggct tttttctttc tgcacattcc     3000

attctgaaat gggaaaagat attctcagat ctccccatgt caggccatct gccacactct     3060

gcatgctgca gaagcttttc tgtaaggata gggtcttcac tcccaggaaa agaggcagtc     3120

agaggctagc tgcctgtgga acagtgacaa tcatggaaaa taggcattta cattgttagg     3180

ctacatgggt agatgggttt ttgtacaccc actaaagggg tctatgatag tgtgactact     3240

ttgactactg gggccaaggc accactctca cagtctcctc aggtgagtcc ttacaacctc     3300

tctcttctat tcagcttaaa tagattttac tgcatttgtt gggggggaaa tgtgtgtatc     3360

tgaatttcag gtcatgaagg actagggaca ccttgggagt cagaaagggt cattgggagc     3420

cctggctgat gcagacagac atcctcagct cccagacttc atggccagag atttataggg     3480

atcctggcca gcattgccgc taggtccctc tcttctatgc tttctttgtc cctcactggc     3540

ctccatctga gatcatcctg gagccctagc caaggatcat ttattgtcag gggtctaatc     3600

attgttgtca caatgtgcct ggtttgctta ctggggccaa gggactctgg tcactgtctc     3660

tgcaggtgag tcctaacttc tcccattcta aatgcatgtt ggggggattc tgagccttca     3720

ggaccaagat tctctgcaaa cgggaatcaa gattcaaccc ctttgtccca aagttgagac     3780

atgggtctgg gtcagggact ctctgcctgc tggtctgtgg tgacattaga actgaagtat     3840

gatgaaggat ctgccagaac tgaagcttga agtctgaggc agaatcttgt ccagggtcta     3900

tcggactctt gtgagaatta ggggctgaca gttgatggtg acaatttcag ggtcagtgac     3960

tgtctggttt ctctgaggtg aggctggaat ataggtcacc ttgaagacta aagaggggtc     4020

caggggcttc tgcacaggca gggaacagaa tgtggaacaa tgacttgaat ggttgattct     4080

tgtgtgacac caggaattgg cataatgtct gagttgccca ggggtgattc tagtcagact     4140

ctggggtttt tgtcgggtat agaggaaaaa tccactattg tgattactat gctatggact     4200

actggggtca aggaacctca gtcaccgtct cctcaggtaa gaatggcctc tccaggtctt     4260

tatttttaac ctttgttatg gagttttctg agcattgcag actaatcttg gatatttgtc     4320

cctgagggag ccggctgaga gaagttggga aataaactgt ctagggatct cagagccttt     4380

aggacagatt atctccacat ctttgaaaaa ctaagaatct gtgtgatggt gttggtggag     4440

tccctggatg atgggatagg gactttggag gctcatttga gggagatgct aaaacaatcc     4500

tatggctgga gggatagttg gggctacgcg tttttaaccc tagaaagata gtctgcgtaa     4560

aattgacgca tgcattcttg aaatattgct ctctctttct aaatagcgcg aatccgtcgc     4620

tgtgcattta ggacatctca gtcgccgctt ggagctcccg tgaggcgtgc ttgtcaatgc     4680

ggtaagtgtc actgattttg aactataacg accgcgtgag tcaaaatgac gcatgattat     4740

cttttacgtg acttttaaga tttaactcat acgataatta tattgttatt tcatgttcta     4800

cttacgtgat aacttattat atatatattt tcttgttata gatatcgcta gtggatccgg     4860

ctggttcttt ccgcctcaga aggtactttt tttttttttt tttttttttt tttttttttt     4920

tttttttttt tttttttttt ttttttaaat ttttgggaat ttattgattt gcatttaaaa     4980

gggaactgct gacaaagatt cactggtaat aatttgaaca agttggaaaa tacagtcaac     5040

attactgaaa cactactaaa ataattccag gacagaacaa aacttcttag atgctgtctt     5100

tgatgtgaaa attgactgct tcttactttt ctaacacacg gtggtataat taacaatatt     5160

caatcacttc tattctttcc tgcatatata aaaattaaaa taccaattaa aaaactaata     5220

tatcttctct ttatttctta cagatatgag ttcaatgttt cactcaatag tgctgtggtt     5280

taagagaatt ttttcattta caagttaaac aacaatccgc ccaaagggaa ctgatagtct     5340

ataggctcat agtgcaaata aacagtttag gaatgcagca actgacattt ctaaagtaca     5400

aaacagataa aattcttaga agatacatgc aaaaagctct actaagcaga tggccacaga     5460

actagaacat tgataatttt actggcgatg tcaataggac tccagatgtt tccaaactca     5520

acttgaactc tcatcttagg ctttgtattt tgcttttcca gtttcactaa tgacacaaac     5580

atgattcaaa tccctgaagt attcattata gtcaagggca tatcctacaa caaacttgtc     5640

tggaatttca aatccaacaa agtctggctt atatccaaca cttcgtgggg tccttttcac     5700

cagcaagctt gcgaccttga ccatctttgg attatactgc ctgaccaagg aaagcaaagt     5760

ctgcattgtt ttgccagtgt caattatatc ttccacaatc aagacattct ttccagttaa     5820

agttgagaga tcatctccac caattacttt tatgtcccct gttgactggt cattacaata     5880

gctcttcagt ctgataaaat ctacagtcat aggaatggat ctatcactat ttctattcag     5940

tgctttgatg taatccagca ggtcagcaaa gaatttatag ccccccttga gcacacagag     6000

ggctacaatg tgatggcctc ccatctcctt catcacatct cgagcaagac gttcagtcct     6060

acagaaataa aatcaggaat ttaatagaaa gtttcataca ttaaacttta taacaaacac     6120

ctcttagtca ttaaacttcc acaccaacct gggcaatata gtgagacccc atgcctgcaa     6180

aaaaaaaaaa attagccagg catggtagca tgtacctgta gtcccagcta cttgagaggt     6240

gaggtgggaa aatcacttta gtgcaggatg ttgaggctgg agtgaactgt gattgtgcca     6300

ctgcactcca gcctggacaa tagagcaaga ccttgtctca aaaaaatgca ttaaaaattt     6360

tttttaaatc ttccacgtaa cacatccttt gccctcatgt ttcataaggt aaaaaatttg     6420

ataccttcaa aaaaaccaag cataccacta tcataatttt ttttaaatgc aaataaaaac     6480

aagataccat tttcacctat cagactggca ggttctgatt aaatgaaatt tcttggataa     6540

tatacaatat taagagagac tgtagaaact gggccagtgg ctcatgcctg taatcccagc     6600

actttgggag gctgggtaac atggcgaacc ctgtttctac aaaataaaaa tattagctgg     6660

gagtggtggc gcacacctat agtcccagct actcaggagg ctgaggtgga aggatcgctt     6720

gaacccagga ggttgagact gcagtgaact gtgatcattc tgctgcactg caccccagcc     6780

tgggcaacag agaccttgtc tcaaaaaaaa aaaaaaaaga gacaaattgt gaagagaaag     6840

gtactctcat ataacatcag gagtataaaa tgattcaact tcttagagga aaatttggca     6900

ataccaaaat attcaataaa ctctttcccc ttgacccaga aattccactt gaataaagct     6960

gaacaagtac caaacatgta aaagaatgtt tcttctagta cagtcggtaa gaacaaaata     7020

gtgtctatca atagtggact ggttaaatca gttatggtat ctccataaga cagaatgcta     7080

tgcaaccttt aaaatatatt agatagctct agacagtgga tcccctcgag ggacctaata     7140

acttcgtata gcatacatta tacgaagtta tattaagggt tattgaatat gtcgactaga     7200

cacactaata ttaaaagtgt ccaataacat ttaaaactat actcatacgt taaaatataa     7260

atgtatatat gtacttttgc atatagtata catgcatagc cagtgcttga gaagaaatgt     7320

gtacagaagg ctgaaaggag agaactttag tcttcttgtt tatggcctcc atagttagaa     7380

tattttataa cacaaatatt ttgatattat aattttaaaa taaaaacaca gaatagccag     7440

acatacaatg caagcattca ataccaggta aggtttttca ctgtaattga cttaacagaa     7500

aattttcaag ctagatgtgc ataataataa aaatctgacc ttgccttcat gtgattcagc     7560

cccagtccat taccctgttt aggactgaga aatgcaagac tctggctaga gttccttctt     7620

ccatctccct tcaatgttta ctttgttctg gtccctacag agtcccacta taccacaact     7680

gatactaagt aattagtaag gccctcctct tttattttta ataaagaaga ttttagaaag     7740

catcagttat ttaataagtt ggcctagttt atgttcaaat agcaagtact cagaacagct     7800

gctgatgttt gaaattaaca caagaaaaag taaaaaacct cattttaaga tcttacttac     7860

ctgtccataa ttagtccatg gggaataaac accctttcca aatcctcagc ataatgatta     7920

ggtatgcaaa ataaatcaag gtcataacct ggttcatcat cactaatcac gacgccaggg     7980

ctgcgggtcg ccataacgga gccggccggc gcgcgggctg aataacttcg tataatgtgt     8040

actatacgaa gttatttgtt caggaggagg aagccggtgg cggagcagag gaggaggcgg     8100

aggcgcagca agaccccccc ccccctgcag gtcgaaaggc ccggagatga ggaagaggag     8160

aacagcgcgg cagacgtgcg cttttgaagc gtgcagaatg ccgggcctcc ggaggacctt     8220

cgggcgcccg ccccgcccct gagcccgccc ctgagcccgc ccccggaccc accccttccc     8280

agcctctgag cccagaaagc gaaggagcaa agctgctatt ggccgctgcc ccaaaggcct     8340

acccgcttcc attgctcagc ggtgctgtcc atctgcacga gactagtgag acgtgctact     8400

tccatttgtc acgtcctgca cgacgcgagc tgcggggcgg gggggaactt cctgactagg     8460

ggaggagtag aaggtggcgc gaaggggcca ccaaagaacg gagccggttg gcgcctaccg     8520

gtggatgtgg aatgtgtgcg aggccagagg ccacttgtgt agcgccaagt gcccagcggg     8580

gctgctaaag cgcatgctcc agactgcctt gggaaaagcg cctcccctac ccggtagata     8640

tctataacaa gaaaatatat atataataag ttatcacgta agtagaacat gaaataacaa     8700

tataattatc gtatgagtta aatcttaaaa gtcacgtaaa agataatcat gcgtcatttt     8760

gactcacgcg gtcgttatag ttcaaaatca gtgacactta ccgcattgac aagcacgcct     8820

cacgggagct ccaagcggcg actgagatgt cctaaatgca cagcgacgga ttcgcgctat     8880

ttagaaagag agagcaatat ttcaagaatg catgcgtcaa ttttacgcag actatctttc     8940

tagggttaaa agaattcgat atcaagctta tcgatgtagt tggagatttt cagtttttag     9000

aataaaagta ttagttgtgg aatatacttc aggaccacct ctgtgacagc atttatacag     9060

tatccgatgc atagggacaa agagtggagt ggggcacttt ctttagattt gtgaggaatg     9120

ttccgcacta gattgtttaa aacttcattt gttggaagga gagctgtctt agtgattgag     9180

tcaagggaga aaggcatcta gcctcggtct caaaagggta gttgctgtct agagaggtct     9240

ggtggagcct gcaaaagtcc agctttcaaa ggaacacaga agtatgtgta tggaatatta     9300

gaagatgttg cttttactct taagttggtt cctaggaaaa atagttaaat actgtgactt     9360

taaaatgtga gagggttttc aagtactcat ttttttaaat gtccaaaatt tttgtcaatc     9420

aatttgaggt cttgtttgtg tagaactgac attacttaaa gtttaaccga ggaatgggag     9480

tgaggctctc tcatacccta ttcagaactg acttttaaca ataataaatt aagtttaaaa     9540

tatttttaaa tgaattgagc aatgttgagt tggagtcaag atggccgatc agaaccagaa     9600

cacctgcagc agctggcagg aagcaggtca tgtggcaagg ctatttgggg aagggaaaat     9660

aaaaccacta ggtaaacttg tagctgtggt ttgaagaagt ggttttgaaa cactctgtcc     9720

agccccacca aaccgaaagt ccaggctgag caaaacacca cctgggtaat ttgcatttct     9780

aaaataagtt gaggattcag ccgaaactgg agaggtcctc ttttaactta ttgagttcaa     9840

ccttttaatt ttagcttgag tagttctagt ttccccaaac ttaagtttat cgacttctaa     9900

aatgtattta gaattcattt tcaaaattag gttatgtaag aaattgaagg actttagtgt     9960

ctttaatttc taatatattt agaaaacttc ttaaaattac tctattattc ttccctctga    10020

ttattggtct ccattcaatt cttttccaat acccgaagca tttacagtga ctttgttcat    10080

gatctttttt agttgtttgt tttgccttac tattaagact ttgacattct ggtcaaaacg    10140

gcttcacaaa tctttttcaa gaccactttc tgagtattca ttttaggaga aatacttttt    10200

ttttaaatga atgcaattat ctagacttat ttcagttgaa catgctggtt ggtggttgag    10260

aggacactca gtcagtcagt gacgtgaagg gcttctaagc cagtccacat gctctgtgtg    10320

aactccctct ggccctgctt attgttgaat gggccaaagg tctgagacca ggctgctgct    10380

gggtaggcct ggactttggg tctcccaccc agacctggga atgtatggtt gtggcttctg    10440

ccacccatcc acctggctgc tcatggacca gccagcctcg gtggctttga aggaacaatt    10500

ccacacaaag actctggacc tctccgaaac caggcaccgc aaatggtaag ccagaggcag    10560

ccacagctgt ggctgctgct cttaaagctt gtaaactgtt tctgcttaag agggactgag    10620

tcttcagtca ttgctttagg gggagaaaga gacatttgtg tgtcttttga gtaccgttgt    10680

ctgggtcact cacatttaac tttccttgaa aaactagtaa aagaaaaatg ttgcctgtta    10740

accaataatc atagagctca tggtattttg aggaaatctt agaaaacgtg tatacaattg    10800

tctggaatta tttcagttaa gtgtattagt tgaggtactg atgctgtctc tacttcagtt    10860

atacatgtgg gtttgaattt tgaatctatt ctggctcttc ttaagcagaa aatttagata    10920

aaatggatac ctcagtggtt tttaatggtg ggtttaatat agaaggaatt taaattggaa    10980

gctaatttag aatcagtaag gagggaccca ggctaagaag gcaatcctgg gattctggaa    11040

gaaaagatgt ttttagtttt tatagaaaac actactacat tcttgatcta caactcaatg    11100

tggtttaatg aatttgaagt tgccagtaaa tgtacttcct ggttgttaaa gaatggtatc    11160

aaaggacagt gcttagatcc aaggtgagtg tgagaggaca ggggctgggg tatggatacg    11220

cagaaggaag gccacagctg tacagaattg agaaagaata gagacctgca gttgaggcca    11280

gcaggtcggc tggactaact ctccagccac agtaatgacc cagacagaga aagccagact    11340

cataaagctt gctgagcaaa atttagtgaa caaggttgac agcctggcta ggaagctagg    11400

ctctagttaa gcacagttgg actgagatgt gtaggcttcc ctgagccctt caaaaatgtg    11460

ctaagctgag atgattactc tgaggtagcc aaagctggac ttgagcagga acgaggtaga    11520

ctgcaatgag ctgaattgag ctaggccggc taagctaaac taggctgact taaccaagat    11580

agccaaattg gaatgaattg tcttgatctg ggctgattgg agctaaactc tactggactg    11640

ctctgaactg agctgtgttg ggctgtgttg tgctggggtg agctgagcta gcatgagcta    11700

ctctgtggta gctggggtga gctgggatga gctgagctgg gtgagctgag ctgggtgagc    11760

tgagctgggt tagctgagct ggggtgagct ggggtaagct ggggtgagct gagctgggtg    11820

agctgagctg ggtgagctga gctgagctgg gtgagctggg gtaagctggg gtgagctggg    11880

ctgacctgag gtggttgagc tgagctgggt gagcagagct gaggtgagct gagctgagct    11940

gggtgagcag agctggggtg agctgagctg agctgggctg gggtgagctg agctgagctg    12000

ggtgagctga gctgggtgag ttgagctgag ctgggtaagc tgagctgagc tgggtgagca    12060

gagctggggg tgagctgagc tggatgagct gggctgaact ggggtgagct ggggtggggt    12120

gagctgggtg agctgagctg ggctgagctg ggctgagctg gggtgagctg agctgggatg    12180

agctgggctg agctgggctg agctgagctg ggctgggctg agctgagctg ggctgagctg    12240

ggctgggctg ggctgggctg ggctgggctg agctgggctg agctgggctg aactggggtg    12300

agctggggtg gggtgagctg ggtgagctga gctgggctga gctgggctga gctggggtga    12360

gctgggtgag ctgagctggg ctgagctggg ctgagctggg ctgagctgag ctgggctggg    12420

ctaagctgag ctggactgag ctgggctgag ctgggctgag ctgagctggg ctgggctggg    12480

ctgggctgag ctgggctgag ctgggctgag ctgagctggg atgggctggg atgagctgaa    12540

ctgggtgagc tgagctgggg tgagatgagc tgaacagggc tgaactgggg tgagctgagc    12600

tgggatgagc tggggtgagc tgagctgggt gagatgagct gggtgagctg agctgagctg    12660

ggctgagctg ggtgagctga gctgggtgag atgagctggg gtgagctgag ctggggtgag    12720

ctgagctggg tgagctgggc tgagctgggc tgggtgagct gagctgggtt gagctgagct    12780

gggctgagct gggctgagct gggctgagct gggctgagct gggctgagct gagctgagct    12840

gggatgagca gggctgggat gagctgggct gagctgagct gggatgagct gggtgagctg    12900

agctggggtg agatgagctg gggtgagctg agctggggtg agctgagctg ggatgagcta    12960

ggtgagctga gttggggtga gctgagctgg ggtgagctgg gctgggtgaa ctaaactagg    13020

gtgagctggg ctgagctgat ctggttgagc tgggctgggt gagctgagct gggtgaactg    13080

agctggggtg agctgaactg agctgggtga gctggggtga gctgagctga gctgggtgaa    13140

ctgagctgag ttgagttggg tgagctgagc tgggtgagct gaactgagct ggactgagct    13200

ggggtgagct ggggtgagct gggctggatg agctgagctg ggtgagatga gctgaacagg    13260

gctgaactgg ggtgagctga gctgggatga gctggggtga gctgagctgg gtgagatgag    13320

ttggggtgag ctgaactgag ctggactgag ctggggtgag ttgggctagg tgagctgaac    13380

tggggtgagc tgagctgggg tgagatgagc tgaacaggtc tgaactggga tgagctggga    13440

tgagctgggg tgagctgggg tgagctgagt tgggtgagct gagctgggtg agctgagctg    13500

gggtgagctg agctgggatt agctggctga gctgggatga gctgggtgag ctgagttggg    13560

gtgagctgag ctggggtgag ctgggctggg tgaactaaac tagggtgagc tgggctgagc    13620

tgatctggtt gagctgagct ggggtgagct gggctgagct gggctgggtg agctgagctg    13680

ggtgaactga gctggggtga gctgaactga gctgggtgag ctggggtgag ctggggtgag    13740

ctgagctgag ctgggtgaac tgagctgagt tgagttgggt gagctgagct gggtgagctg    13800

aactgagctg gactgagctg gggtgagctg gggtgagctg ggctgggtga gctgagctgg    13860

gtgagctgag ctgggctgag ctggggtgag ctgagctgag ctgggctggg tgagctgagc    13920

tgggtgagct gagctggggt gagctgagct gagctgggtg agctgggctg agctgagctg    13980

agctggggtg agctggggtg agctgggctg ggtgagatga gctgtgctgg gctgggtgag    14040

ctgagctggg tgaactgagc tgagctgagt tgggtgagct gagctgggtg agctgagctg    14100

ggctgagctg gggtgagctg agctgagctg gggtgagctg gggtgagctg ggctgggtga    14160

gctgagctgg gtgagatgag ctgtgctggg ctgggtgagc tgagctgggt gaactgagct    14220

gagctgagtt gggtgagctg agttgagtga gctgagttgg gtgagctgag ctggggtgag    14280

ctgaactgag ctggactgag ctggggtgag ctgagctggc tgagctgagc tgggtgagct    14340

gagctgagct gagctgagct gagctgagct gggctgagct gggctgggtg agctgggctg    14400

agctgggctg ggtgagctgg gctgagctgg gctgggtgag ctaagctggg tgagctggga    14460

tgggtgagct ggcctgagct gggtgagctg agctgaaagg atctgggttg gagtcagctt    14520

tgcttgggtg agctgagcag ggtttagctg agctaggatg agttgagttg gctgggctga    14580

gctgggatga agtaggctaa ataagctagc ttgagctaaa tagagctggg gtgagctgta    14640

cttaaatgag ctgtgattga agtgggctgg gatgagctca gctgaactgg gctagctgat    14700

gtggatgatg gtgaggctga gttaggatga gcatgactga gctggtttgg acatgaatga    14760

gctggacccg gctgacttgg gctggttgag ctttgcaaga tgatgtggac taaactgggc    14820

tagctggcag gatgagagag gttgaactag gctcagatga gctaggctga gcagggctta    14880

ggtgaggtgg tttgggatga gctgggataa gttgggctca gatgagctac catgaactgg    14940

gctgaggtgg cctgggagaa catgaatcga gttgcactga gtacagccag gatgaactgg    15000

gataaactgg gctaaactgg gttgggctaa gaatggactg cctgagttat gctaagctga    15060

gctgggatga attggggatt gtcaagactt aaatgagcca gactgaactg gttggacttg    15120

ggtgagctga ggggacctgc tgcagggccg gcatagctga gttgaattta gatgaggaag    15180

ggtgagctag actgagcaag gctagactgc ttatgctgag ctacactaac ctggcctgag    15240

ttgggccagg ctttgttggc catgtctaaa ctgagttaag atcaacaggg agtctagagg    15300

ggtaggggat gaactaagat gaattacact agctgagctg aattgagata aggtatggta    15360

acctgagctg aactggaaag agatgtactg gataacctta actgggctga gatgagctag    15420

gtctacccag gcctggatca gcttaattag ggtaggctag accaaactgt agcagtatgt    15480

attagcctgt gccaagctgg gctacattaa actaaactgg acttagctag gctcagatta    15540

gtttcgctac tctagatggg gtaagttggg ccaaactggg atgaactaat ttaactagcc    15600

tgagatgggc agatctgaat gagcagagct gggatgaact gaatgagttt caccaggcct    15660

ggaccagtta ggctaggacc tcgttctata gaggcagact gtgtgctaca gtggagtttc    15720

aagatgattc catgagtcct ccccgccccc aacataaccc accttcctcc taccctacaa    15780

gcctgtctgg tgtgtaaatc ccagctttgt gtgctgatac agaagcctga gcccctcccc    15840

cacctccacc tacctattac tttgggatga gaatagttct cccagccagt gtctcagagg    15900

gaagccaagc aggacaggcc caaggctact tgagaagcca ggatctaggc ctctccctga    15960

gaacgggtgt tcatgcccct agagttggct gaagggccag atccacctac tctagaggca    16020

tctctccctg tctgtgaagg cttccaaagt cacgttcctg tggctagaag gcagctccat    16080

agccctgctg cagtttcgtc ctgtatacca ggttcaccta ctaccatatc tagccctgcc    16140

tgccttaaga gtagcaacaa ggaaatagca gggtgtagag ggatctcctg tctgacagga    16200

ggcaagaaga cagattctta cccctccatt tctcttttat ccctctctgg tcctcagaga    16260

gtcagtcctt cccaaatgtc ttccccctcg tctcctgcga gagccccctg tctgataaga    16320

atctggtggc catgggctgc ctggcccggg acttcctgcc cagcaccatt tccttcacct    16380

ggaactacca gaacaacact gaagtcatcc agggtatcag aaccttccca acactgagga    16440

cagggggcaa gtacctagcc acctcgcagg tgttgctgtc tcccaagagc atccttgaag    16500

gttcagatga atacctggta tgcaaaatcc actacggagg caaaaacaaa gatctgcatg    16560

tgcccattcc aggtaagaac caaaccctcc cagcaggggt gcccaggccc aggcatggcc    16620

cagagggagc agcggggtgg ggcttaggcc aagctgagct cacaccttga cctttcattc    16680

cagctgtcgc agagatgaac cccaatgtaa atgtgttcgt cccaccacgg gatggcttct    16740

ctggccctgc accacgcaag tctaaactca tctgcgaggc cacgaacttc actccaaaac    16800

cgatcacagt atcctggcta aaggatggga agctcgtgga atctggcttc accacagatc    16860

cggtgaccat cgagaacaaa ggatccacac cccaaaccta caaggtcata agcacactta    16920

ccatctctga aatcgactgg ctgaacctga atgtgtacac ctgccgtgtg gatcacaggg    16980

gtctcacctt cttgaagaac gtgtcctcca catgtgctgc cagtgagtgg cctgggataa    17040

gcccaatgcc tagccctccc agattaggga agtcctccta caattatggc caatgccacc    17100

cagacatggt catttgctcc ttgaactttg gctccccaga gtggccaagg acaagaatga    17160

gcaataggca gtagaggggt gagaatcagc tggaaggacc agcatcttcc cttaagtagg    17220

tttgggggat ggagactaag cttttttcca acttcacaac tagatatgtc ataacctgac    17280

acagtgttct cttgactgca ggtccctcca cagacatcct aaccttcacc atccccccct    17340

cctttgccga catcttcctc agcaagtccg ctaacctgac ctgtctggtc tcaaacctgg    17400

caacctatga aaccctgaat atctcctggg cttctcaaag tggtgaacca ctggaaacca    17460

aaattaaaat catggaaagc catcccaatg gcaccttcag tgctaagggt gtggctagtg    17520

tttgtgtgga agactggaat aacaggaagg aatttgtgtg tactgtgact cacagggatc    17580

tgccttcacc acagaagaaa ttcatctcaa aacccaatgg taggtatccc cccttccctt    17640

cccctccaat tgcaggaccc ttcctgtacc tcatagggag ggcaggtcct cttccaccct    17700

atcctcacta ctgtcttcat ttacagaggt gcacaaacat ccacctgctg tgtacctgct    17760

gccaccagct cgtgagcaac tgaacctgag ggagtcagcc acagtcacct gcctggtgaa    17820

gggcttctct cctgcagaca tcagtgtgca gtggcttcag agagggcaac tcttgcccca    17880

agagaagtat gtgaccagtg ccccgatgcc agagcctggg gccccaggct tctactttac    17940

ccacagcatc ctgactgtga cagaggagga atggaactcc ggagagacct atacctgtgt    18000

tgtaggccac gaggccctgc cacacctggt gaccgagagg accgtggaca agtccactgg    18060

taaacccaca ctgtacaatg tctccctgat catgtctgac acaggcggca cctgctattg    18120

accatgctag cgctcaacca ggcaggccct gggtgtccag ttgctctgtg tatgcaaact    18180

aaccatgtca gagtgagatg ttgcatttta taaaaattag aaataaaaaa aatccattca    18240

aacgtcactg gttttgatta tacaatgctc atgcctgctg agacagttgt gttttgcttg    18300

ctctgcacac accctgcata cttgcctcca ccctggccct tcctctacct tgccagtttc    18360

ctccttgtgt gtgaactcag tcaggcttac aacagacaga gtatgaacat gcgattcctc    18420

cagctacttc tagatatatg gctgaaagct tgcctaacct ggtgcaggca gcattcaggc    18480

acatatatag acacacatgc atttatacat agatatatag gtacacatgt gtagacacat    18540

acatgaatgt gtattcatgg acacacagac aaaggtacac atatatacac atgagttcat    18600

gcgcacacac atgcatggac acttacaaac gccttcagag acaaataggc atagacacac    18660

aaccactcac agaaacagat accaatatgc atggtcctgt gtacacagaa acagactata    18720

ggcaaatata cacaaataaa ctatatagat acaaagatat gcatatacac acatgtacag    18780

aaacatcttc acatgtgtac actaacatgt ggacaggtat agcacacaga tacacctgga    18840

ctctgaccag ggctgtaatc tccaaggctc acggctcaga gagcctacac taggctgggt    18900

cactgatact cctcaggagc ccactctatg attgggagag ataaccccag gtacaaagta    18960

tgcctatctg tctcaacacc atggggcaga agatactcca ctaaccaccc atgacagaaa    19020

gttagccttg gctgtgtctc cattaataga acacctcaga agaccaatgt gaaattgcct    19080

aacccactca cacccaccct gatctccagt tcaaaatgca gaaaacataa tgcagttgtc    19140

caaaagatgc cccaaccaca cacacacaca cacacacaca cacacacaca cacacacaca    19200

cacacataca cacacacaca ccatcaagga gcctctgtaa ggagtcacca cccaataaca    19260

ctgcctcttt gggctcatat cctggacatt cttcatattc atatccattt ggggcctagg    19320

ctttagatat ccccaagggc tcatctttac agggatcaga gatcccaata aatgccctgg    19380

tcccacagcc tccctcaggt atctgtctgt ttatctcttg gtacctttct tagacgttag    19440

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt    19500

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa    19560

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt    19620

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt    19680

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt    19740

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg    19800

tattatcccg tgttgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga    19860

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa    19920

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga    19980

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa    20040

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca    20100

ccacgatgcc tgcagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta    20160

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac    20220

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc    20280

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag    20340

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga    20400

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt    20460

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata    20520

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag    20580

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa    20640

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt    20700

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt ctagtgtagc    20760

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa    20820

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa    20880

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc    20940

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa    21000

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa    21060

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg    21120

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc    21180

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg    21240

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg    21300

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg    21360

aagcggaaga gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc    21420

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagtatacac    21480

tccgctatcg ctacgtgact gggtcatggc tgcgccccga cacccgccaa cacccgctga    21540

cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg tgaccgtctc    21600

cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga ggcagctgcg    21660

gtaaagctca tcagcgtggt cgtgaagcga ttcacagatg tctgcctgtt catccgcgtc    21720

cagctcgttg agtttctcca gaagcgttaa tgtctggctt ctgataaagc gggccatgtt    21780

aagggcggtt ttttcctgtt tggtcactga tgcctccgtg taagggggat ttctgttcat    21840

gggggtaatg ataccgatga aacgagagag gatgctcacg atacgggtta ctgatgatga    21900

acatgcccgg ttactggaac gttgtgaggg taaacaactg gcggtatgga tgcggcggga    21960

ccagagaaaa atcactcagg gtcaatgcca gcgcttcgtt aatacagatg taggtgttcc    22020

acagggtagc cagcagcatc ctgcgatgca gatccggaac ataatggtgc agggcgctga    22080

cttccgcgtt tccagacttt acgaaacacg gaaaccgaag accattcatg ttgttgctca    22140

ggtcgcagac gttttgcagc agcagtcgct tcacgttcgc tcgcgtatcg               22190


<210>  3
<211>  14130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Targetting vector (short version)

<400>  3
gcggccgcaa cctgggcaaa tgggagctta gcaacaatgt agggggctgg acctagactt       60

cctacacatg tgtaacagat gtgcagcttg gtcttcatgt gtgtattacc ctaacatttg      120

gagcaggagc tgtctctgac tctgttgcct gccattggat ccccttcccc tgcttgggct      180

gccttgtttg gccttagtag gaaaggatgt gcttagtcct gctgtgactt gatgtcccta      240

ggcagaatga taccccaggg gggctcccca tctctgagga gatgggcaaa gggtaatggt      300

tggagggact tgtgaggctg ggactgggag gagagaaagg agacagctgt aactggaatg      360

atgttaagtg aacaaatgaa tggatagatt agatagacag atagacagac agacagacag      420

acagacagac agacagacag acagacagat agaaagatag atagataagg ggaaaaagaa      480

acgtagctga gcaagccaga gagagcaagc caaataagca gcattcctcc atgacttttc      540

cttcagctcc tgcctatgag tctgccttga cttccctcag tgattggttg taagttaaaa      600

ggtgaaataa accctttctt tgacaagttg cttttggttc tgatttttat cacagcaaga      660

gaaaatcaaa ctagaacaaa catgtatttt tcctggcaca tgtccatagt aaggcagaaa      720

tgatcttcag acctagacca tagatactac agagagcaga agtgtagata ggtggactta      780

ctgtatgatt gtaatccaag taaatctaca tagctagaga gctagaggaa aggccaaagc      840

ttcctctggg aggtcagatc ctgtcgcact gtagccaata aggcatattg catcacagga      900

aaggactaag acccaggctg gcaatagtgt ctgtatctta actagatctc tctagtgagt      960

gaggaagtaa atttgtgaga gcccagactg tgggctcgga aggtacctgc catgcccctg     1020

ttagtaactg agtactacag caggagcagg tgttctctag aaagcctgag acaactctac     1080

ttcttctctc aagagaccac ctaatacagg cctgagagaa cagactctgg aaatagatgg     1140

gacttacgga gctaagatct agagctcatc tacagagcag aatcccagcc aagagaacaa     1200

agaatactga ctctctcctg ttccctactc ctagagttct aaaacacact atagggaagg     1260

gagcctctag acctccgtcc attccccatc ttgctcattc catcttccca tgtccccagg     1320

tctccaagcc acagacacca cctttcctat tcacccacct ttctgtgtcc ctaggtcccc     1380

aggccatagt cacctccccc cacaccccgc tcaccctgcc ccatctatgc ccctagatgc     1440

ttacttacca gagtcttttg tctgacgtgg ggctacaagc atctatgctc cctaagcacc     1500

tactgctgac ctgtaggacc cagctctgaa ccaactcata taagtaaata cagactctcc     1560

cctgtcttag gatggccccc tgggtcagga ggagaccact gccaaggaac cttctcttag     1620

agcactgaac tcctcccctg taccacttag gacagacctg agacctatta ttactgatta     1680

ccagagctct ggcagtgacc acggaggaga tagatccacc ctggacacag gaaacacagc     1740

accagagata ctgcttcatc acaacagtag agtgacactt tagactttaa tttgggtcac     1800

tttcctgctg tagaggtggg atcagaaagc aaagagcagt atgagtgcct gataggcacc     1860

caagtacact atagagtact catggtgaat aaggtacctc catggcttcc cagggagggg     1920

cactgcccca cccccaccat cacagacctt tctccatagt tgataactca gacacaagtg     1980

aatgacagat ggacctccat ctgctcttat tttaaaaaga agacaaaccc cacaggctcg     2040

agaactttag cgactgtttt gagagaaatc attggtccct gactcaagag atgactggca     2100

gattggggat cagaataccc atactctgtg gctagtgtga ggtttaagcc tcagagtccc     2160

tgtggtctct gactggtgca aggttttgac taagcggagc accacagtgc taactgggac     2220

cacggtgaca cgtggctcaa caaaaacctt ctgtttggag ctctccaggg gcagcctgag     2280

ctatgaggaa gtagagaggc ttgagaaatc tgaggaagaa aagagtagat ctgagaggaa     2340

aggtagcttt ctggaggtca ggagacagtg cagagaagaa cgagttactg tggacaggtc     2400

ttagatgggg aaagaatgag caaatgcaag catcagaagg gtggatgcaa tgtcctgcca     2460

aggacttacc aagaggatcc ccggacagag caggcaggtg gagttgactg agaggacagg     2520

ataggtgcag gtccctctct tgtttccttt ctccttctcc tgtttccttc ttctcttgtc     2580

acaggtctca ctatgctagc caaggctagc ctgaaagatt accatcctac agatgggccc     2640

atccagttga attaaggtgg agatctctcc aaacatctga gtttctgagg cttggatgcc     2700

actggggacg ccaagggact ttgggatggg tttggttggc cccagatgaa gggctacttc     2760

actgggtcta taattactct gatgtctagg accagggggc tcaggtcact caggtcaggt     2820

gagtcctgca tctggggact gtggggttca ggtggcctaa ggcaggatgt ggagagagtt     2880

ttagtatagg aacagaggca gaacagagac tgtgctactg gtacttcgat gtctggggca     2940

cagggaccac ggtcaccgtc tcctcaggta agctggcttt tttctttctg cacattccat     3000

tctgaaacgg gaaaagatat tctcagatct ccccatgtca ggccatctgc cacactctgc     3060

atgctgcaga agcttttctg taaggatagg gtcttcactc ccaggaaaag aggcagtcag     3120

aggctagctg cctgtggaac agtgacaatc atggaaaata ggcatttaca ttgttaggct     3180

acatgggtag atgggttttt gtacacccac taaaggggtc tatgatagtg tgactacttt     3240

gactactggg gccaaggcac cactctcaca gtctcctcag gtgagtcctt acaacctctc     3300

tcttctattc agcttaaata gattttactg catttgttgg gggggaaatg tgtgtatctg     3360

aatttcaggt catgaaggac tagggacacc ttgggagtca gaaagggtca ttgggagccc     3420

tggctgacgc agacagacat cctcagctcc catacttcat ggccagagat ttatagggat     3480

cctggccagc attgccgcta ggtccctctc ttctatgctt tctttgtccc tcactggcct     3540

ccatctgaga tcatcctgga gccctagcca aggatcattt attgtcaggg gtctaatcat     3600

tgttgtcaca atgtgcctgg tttgcttact ggggccaagg gactctggtc actgtctctg     3660

caggtgagtc ctaacttctc ccattctaaa tgcatgttgg ggggattctg ggccttcagg     3720

accaagattc tctgcaaacg ggaatcaaga ttcaacccct ttgtcccaaa gttgagacat     3780

gggtctgggt cagggactct ctgcctgctg gtctgtggtg acattagaac tgaagtatga     3840

tgaaggatct gccagaactg aagcttgaag tctgaggcag aatcttgtcc agggtctatc     3900

ggactcttgt gagaattagg ggctgacagt tgatggtgac aatttcaggg tcagtgactg     3960

tctggtttct ctgaggtgag gctggaatat aggtcacctt gaagactaaa gaggggtcca     4020

ggggcttctg cacaggcagg gaacagaatg tggaacaatg acttgaatgg ttgattcttg     4080

tgtgacacca ggaattggca taatgtctga gttgcccagg ggtgattcta gtcagactct     4140

ggggtttttg tcgggtatag aggaaaaatc cactattgtg attactatgc tatggactac     4200

tggggtcaag gaacctcagt caccgtctcc tcaggtaaga atggcctctc caggtcttta     4260

tttttaacct ttgttatgga gttttctgag cattgcagac taatcttgga tatttgtccc     4320

tgagggagcc ggctgagaga agttgggaaa taaactgtct agggatctca gagcctttag     4380

gacagattat ctccacatct ttgaaaaact aagaatctgt gtgatggtgt tggtggagtc     4440

cctggatgat gggataggga ctttggaggc tcatttgaag aagatgctaa aacaatccta     4500

tggctggagg gatagttggg gctacgcgtt tttaacccta gaaagatagt ctgcgtaaaa     4560

ttgacgcatg cattcttgaa atattgctct ctctttctaa atagcgcgaa tccgtcgctg     4620

tgcatttagg acatctcagt cgccgcttgg agctcccgtg aggcgtgctt gtcaatgcgg     4680

taagtgtcac tgattttgaa ctataacgac cgcgtgagtc aaaatgacgc atgattatct     4740

tttacgtgac ttttaagatt taactcatac gataattata ttgttatttc atgttctact     4800

tacgtgataa cttattatat atatattttc ttgttataga tatcgctagt ggatcctggt     4860

tctttccgcc tcagaaggta cttttttttt tttttttttt tttttttttt tttttttttt     4920

tttttttttt tttttttttt taaatttttg ggaatttatt gatttgcatt taaaagggaa     4980

ctgctgacaa agattcactg gtaataattt gaacaagttg gaaaatacag tcaacattac     5040

tgaaacacta ctaaaataat tccaggacag aacaaaactt cttagatgct gtctttgatg     5100

tgaaaattga ctgcttctta cttttctaac acacggtggt ataattaaca atattcaatc     5160

acttctattc tttcctgcat atataaaaat taaaatacca attaaaaaac taatatatct     5220

tctctttatt tcttacagat atgagttcaa tgtttcactc aatagtgctg tggtttaaga     5280

gaattttttc atttacaagt taaacaacaa tccgcccaaa gggaactgat agtctatagg     5340

ctcatagtgc aaataaacag tttaggaatg cagcaactga catttctaaa gtacaaaaca     5400

gataaaattc ttagaagata catgcaaaaa gctctactaa gcagatggcc acagaactag     5460

aacattgata attttactgg cgatgtcaat aggactccag atgtttccaa actcaacttg     5520

aactctcatc ttaggctttg tattttgctt ttccagtttc actaatgaca caaacatgat     5580

tcaaatccct gaagtattca ttatagtcaa gggcatatcc tacaacaaac ttgtctggaa     5640

tttcaaatcc aacaaagtct ggcttatatc caacacttcg tggggtcctt ttcaccagca     5700

agcttgcgac cttgaccatc tttggattat actgcctgac caaggaaagc aaagtctgca     5760

ttgttttgcc agtgtcaatt atatcttcca caatcaagac attctttcca gttaaagttg     5820

agagatcatc tccaccaatt acttttatgt cccctgttga ctggtcatta caatagctct     5880

tcagtctgat aaaatctaca gtcataggaa tggatctatc actatttcta ttcagtgctt     5940

tgatgtaatc cagcaggtca gcaaagaatt tatagccccc cttgagcaca cagagggcta     6000

caatgtgatg gcctcccatc tccttcatca catctcgagc aagacgttca gtcctacaga     6060

aataaaatca ggaatttaat agaaagtttc atacattaaa ctttataaca aacacctctt     6120

agtcattaaa cttccacacc aacctgggca atatagtgag accccatgcc tgcaaaaaaa     6180

aaaaaattag ccaggcatgg tagcatgtac ctgtagtccc agctacttga gaggtgaggt     6240

gggaaaatca ctttagtgca ggatgttgag gctggagtga actgtgattg tgccactgca     6300

ctccagcctg gacaatagag caagaccttg tctcaaaaaa atgcattaaa aatttttttt     6360

aaatcttcca cgtaacacat cctttgccct catgtttcat aaggtaaaaa atttgatacc     6420

ttcaaaaaaa ccaagcatac cactatcata atttttttta aatgcaaata aaaacaagat     6480

accattttca cctatcagac tggcaggttc tgattaaatg aaatttcttg gataatatac     6540

aatattaaga gagactgtag aaactgggcc agtggctcat gcctgtaatc ccagcacttt     6600

gggaggctgg gtaacatggc gaaccctgtt tctacaaaat aaaaatatta gctgggagtg     6660

gtggcgcaca cctatagtcc cagctactca ggaggctgag gtggaaggat cgcttgaacc     6720

caggaggttg agactgcagt gaactgtgat cattctgctg cactgcaccc cagcctgggc     6780

aacagagacc ttgtctcaaa aaaaaaaaaa aaagagacaa attgtgaaga gaaaggtact     6840

ctcatataac atcaggagta taaaatgatt caacttctta gaggaaaatt tggcaatacc     6900

aaaatattca ataaactctt tccccttgac ccagaaattc cacttgaata aagctgaaca     6960

agtaccaaac atgtaaaaga atgtttcttc tagtacagtc ggtaagaaca aaatagtgtc     7020

tatcaatagt ggactggtta aatcagttat ggtatctcca taagacagaa tgctatgcaa     7080

cctttaaaat atattagata gctctagaca gtggatcccc tcgagggacc taataacttc     7140

gtatagcata cattatacga agttatatta agggttattg aatatgtcga ctagacacac     7200

taatattaaa agtgtccaat aacatttaaa actatactca tacgttaaaa tataaatgta     7260

tatatgtact tttgcatata gtatacatgc atagccagtg cttgagaaga aatgtgtaca     7320

gaaggctgaa aggagagaac tttagtcttc ttgtttatgg cctccatagt tagaatattt     7380

tataacacaa atattttgat attataattt taaaataaaa acacagaata gccagacata     7440

caatgcaagc attcaatacc aggtaaggtt tttcactgta attgacttaa cagaaaattt     7500

tcaagctaga tgtgcataat aataaaaatc tgaccttgcc ttcatgtgat tcagccccag     7560

tccattaccc tgtttaggac tgagaaatgc aagactctgg ctagagttcc ttcttccatc     7620

tcccttcaat gtttactttg ttctggtccc tacagagtcc cactatacca caactgatac     7680

taagtaatta gtaaggccct cctcttttat ttttaataaa gaagatttta gaaagcatca     7740

gttatttaat aagttggcct agtttatgtt caaatagcaa gtactcagaa cagctgctga     7800

tgtttgaaat taacacaaga aaaagtaaaa aacctcattt taagatctta cttacctgtc     7860

cataattagt ccatggggaa taaacaccct ttccaaatcc tcagcataat gattaggtat     7920

gcaaaataaa tcaaggtcat aacctggttc atcatcacta atcacgacgc cagggctgcg     7980

ggtcgccata acggagccgg ccggcgcgcg ggctgaataa cttcgtataa tgtgtactat     8040

acgaagttat ttgttcagga ggaggaagcc ggtggcggag cagaggagga ggcggaggcg     8100

cagcaagacc cccccccccc tgcaggtcga aaggcccgga gatgaggaag aggagaacag     8160

cgcggcagac gtgcgctttt gaagcgtgca gaatgccggg cctccggagg accttcgggc     8220

gcccgccccg cccctgagcc cgcccctgag cccgcccccg gacccacccc ttcccagcct     8280

ctgagcccag aaagcgaagg agccaaagct gctattggcc gctgccccaa aggcctaccc     8340

gcttccattg ctcagcggtg ctgtccatct gcacgagact agtgagacgt gctacttcca     8400

tttgtcacgt cctgcacgac gcgagctgcg gggcgggggg gaacttcctg actaggggag     8460

gagtagaagg tggcgcgaag gggccaccaa agaacggagc cggttggcgc ctaccggtgg     8520

atgtggaatg tgtgcgaggc cagaggccac ttgtgtagcg ccaagtgccc agcggggctg     8580

ctaaagcgca tgctccagac tgccttggga aaagcgcctc ccctacccgg tagatatcta     8640

taacaagaaa atatatatat aataagttat cacgtaagta gaacatgaaa taacaatata     8700

attatcgtat gagttaaatc ttaaaagtca cgtaaaagat aatcatgcgt cattttgact     8760

cacgcggtcg ttatagttca aaatcagtga cacttaccgc attgacaagc acgcctcacg     8820

ggagctccaa gcggcgactg agatgtccta aatgcacagc gacggattcg cgctatttag     8880

aaagagagag caatatttca agaatgcatg cgtcaatttt acgcagacta tctttctagg     8940

gttaaaagaa ttcgtagttg gagattttca gtttttagaa taaaagtatt agctgcggaa     9000

tatacttcag gaccacctct gtgacagcat ttatacagta tccgatgcat agggacaaag     9060

agtggagtgg ggcactttct ttagatttgt gaggaatgtt ccacactaga ttgtttaaaa     9120

cttcatttgt tggaaggaga gctgtcttag tgattgagtc aagggagaaa ggcatctagc     9180

ctcggtctca aaagggtagt tgctgtctag agaggtctgg tggagcctgc aaaagtccag     9240

ctttcaaagg aacacagaag tatgtgtatg gaatattaga agatgttgct tttactctta     9300

agttggttcc taggaaaaat agttaaatac tgtgacttta aaatgtgaga gggttttcaa     9360

gtactcattt ttttaaatgt ccaaaatttt tgtcaatcaa tttgaggtct tgtttgtgta     9420

gaactgacat tacttaaagt ttaaccgagg aatgggagtg aggctctctc ataccctatt     9480

cagaactgac ttttaacaat aataaattaa gtttaaaata tttttaaatg aattgagcaa     9540

tgttgagttg gagtcaagat ggccgatcag aaccagaaca cctgcagcag ctggcaggaa     9600

gcaggtcatg tggcaaggct atttggggaa gggaaaataa aaccactagg taaacttgta     9660

gctgtggttt gaagaagtgg ttttgaaaca ctctgtccag ccccaccaaa ccgaaagtcc     9720

aggctgagca aaacaccacc tgggtaattt gcatttctaa aataagttga ggattcagcc     9780

gaaactggag aggtcctctt ttaacttatt gagttcaacc ttttaatttt agcttgagta     9840

gttctagttt ccccaaactt aagtttatcg acttctaaaa tgtatttaga attcattttc     9900

aaaattaggt tatgtaagaa attgaaggac tttagtgtct ttaatttcta atatatttag     9960

aaaacttctt aaaattactc tattattctt ccctctgatt attggtctcc attcaattct    10020

tttccaatac ccgaagcatt tacagtgact ttgttcatga tcttttttag ttgtttgttt    10080

tgccttacta ttaagacttt gacattctgg tcaaaacggc ttcacaaatc tttttcaaga    10140

ccactttctg agtattcatt ttaggagaaa tacttttttt ttaaatgaat gcaattatct    10200

agacttattt cggttgaaca tgctggttgg tggttgagag gacactcagt cagtcagtgg    10260

cgtgaagggc ttctaagcca gtccacatgc tctgtgtgaa ctccctctgg ccctgcttat    10320

tgttgaatgg gccaaaggtc tgagaccagg ctgctgctgg gtaggcctgg actttgggtc    10380

tcccacccag acctgggaat gtatggttgt ggcttctgcc acccatccac ctggctgctc    10440

atggaccagc cagcctcggt ggctttgaag gaacaattcc acacaaagac tctggacctc    10500

tccgaaacca ggcaccgcaa atggtaagcc agaggcagcc acagctgtgg ctgctgctct    10560

taaagcttgt aaactgtttc tgcttaagag ggactgagtc ttcagtcatt gctttagggg    10620

gagaaagaga catttgtgtg tcttttgagt accgttgtct gggtcactca catttaactt    10680

tccttgaaaa actagtaaaa gaaaaatgtt gcctgttaac caataatcat agagctcatg    10740

gtattttgag gaaatcttag aaaacgtgta tacaattgtc tggaattatt tcagttaagt    10800

gtattagttg aggtactgat gctgtctcta cttcagttat acatgtgggt ttgaattttg    10860

aatctattct ggctcttctt aagcagaaaa tttagataaa atggatacct cagtggtttt    10920

taatggtggg tttaatatag aaggaattta aattggaagc taatttagaa tcagtaagga    10980

gggacccagg ctaagaaggc aatcctggga ttctggaaga aaagatgttt ttagttttta    11040

tagaaaacac tactacattc ttgatctaca actcaatgtg gtttaatgaa tttgaagttg    11100

ccagtaaatg tacttcctgg ttgttaaaga atggtatcaa aggacagtgc ttagatccaa    11160

ggtgagtgtg agaggacagg ggctggggta tggatacgca gaaggaaggc cacagctgta    11220

cagaattgag aaagaataga gacctgcagt tgaggccagc aggtcggctg gactaactct    11280

ccagccacag taatgaccca gacagagaag gccagactca taaagcttta tcgataccgt    11340

cgacctcgag ggggggcccg gtacctttct tagacgtcag gtggcacttt tcggggaaat    11400

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg    11460

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa    11520

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac    11580

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac    11640

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt    11700

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tgttgacgcc    11760

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca    11820

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc    11880

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag    11940

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa    12000

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgcagcaatg    12060

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa    12120

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg    12180

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt    12240

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt    12300

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag    12360

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat    12420

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct    12480

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct    12540

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca    12600

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc    12660

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc    12720

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct    12780

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag    12840

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc    12900

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg    12960

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag    13020

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt    13080

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac    13140

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg    13200

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc    13260

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg    13320

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt    13380

acaatctgct ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact    13440

gggtcatggc tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc    13500

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga    13560

ggttttcacc gtcatcaccg aaacgcgcga ggcagctgcg gtaaagctca tcagcgtggt    13620

cgtgaagcga ttcacagatg tctgcctgtt catccgcgtc cagctcgttg agtttctcca    13680

gaagcgttaa tgtctggctt ctgataaagc gggccatgtt aagggcggtt ttttcctgtt    13740

tggtcactga tgcctccgtg taagggggat ttctgttcat gggggtaatg ataccgatga    13800

aacgagagag gatgctcacg atacgggtta ctgatgatga acatgcccgg ttactggaac    13860

gttgtgaggg taaacaactg gcggtatgga tgcggcggga ccagagaaaa atcactcagg    13920

gtcaatgcca gcgcttcgtt aatacagatg taggtgttcc acagggtagc cagcagcatc    13980

ctgcgatgca gatccggaac ataatggtgc agggcgctga cttccgcgtt tccagacttt    14040

acgaaacacg gaaaccgaag accattcatg ttgttgctca ggtcgcagac gttttgcagc    14100

agcagtcgct tcacgttcgc tcgcgtatcg                                     14130


<210>  4
<211>  3551
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1399)..(1498)
<223>  n is a, c, g, or t

<400>  4
aagcttgctg agcaaaatta agggaacaag gttgagagcc ctagtaagcg aggctctaaa       60

aagcatggct gagctgagat gggtgggctt ctctgagcgc ttctaaaatg cgctaaactg      120

aggtgattac tctgaggtaa gcaaagctgg gcttgagcca aaatgaagta gactgtaatg      180

aactggaatg agctgggccg ctaagctaaa ctaggctggc ttaaccgaga tgagccaaac      240

tggaatgaac ttcattaatc taggttgaat agagctaaac tctactgcct acactggact      300

gttctgagct gagatgagct ggggtgagct cagctatgct acgctgtgtt ggggtgagct      360

gatctgaaat gagctactct ggagtagctg agatggggtg agatggggtg agctgagctg      420

ggctgagctg gactgagctg agctagggtg agctgagctg ggtgagctga gctaagctgg      480

ggtgagctga gctgagcttg actgagctag ggtgagctgg actgagctgg ggtgagctga      540

gctgagctgg ggtaagctgg gatgagctgg ggtgagctga gctgagctgg agtgagctga      600

gctgggctga gctggggtga gctgggctgg gctgagctgg ggtgagctgg gctgagctgg      660

ggtgagctga gctggggtga gctgagctga gctggggtga gctgagctga gctggggtga      720

gctgagctgg ggtgagctga gctgagctgg gctgagctga ggtgagctga gctggggtga      780

gctgagctgg ggtgagctga gctgagctgg ggtaagctgg gatgagctgg ggtgagctga      840

gctgagctgg agtgagctga gctgggctga gctgggctga gctggggtga gctgagctgg      900

ggtgagctga gctgagctgg gctgagctga ggtgagctga gctggggtga gctgagctga      960

gctggggtga gctgagctga gctggggtga gctgagctgg ggtgagctga gctggggtga     1020

gctgagctga gctggggtga gctgagctgg ggtgagctga gctgagctgg ggtgagctga     1080

gctgagctgg ggtgagctga gctgagctga gctggggtga gctgagctga gctggggtga     1140

gctgagctga gctggggtga gctgagctgg ggtgagctgg gctgagctga gctgggctga     1200

gctgagctga gctgagctga gctggggtga gctgagctgg gctgagctgg ggtgagctgg     1260

gctgagctgg ggtgagctga gctggggtga gctgagctga gctggggtga gctgagctga     1320

gctggggtga gctgagctgg ggtgagctga gctgagctgg gctgagctga gctgagctgg     1380

ggtgagctga gctgagctnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     1440

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnag     1500

ctgagctgag ctgagctgag ctgagctggg gtgagctggg gtgagctgag ctggggtgag     1560

ctgagctgag ctggggtgag ctgagctgag ctgagctgag ctgagctgag ctgggtgagc     1620

tgagctgagc tgagctgggg tgagctgagc tggggtgagc tgagctgagc tggggtgagc     1680

tgagctgggg tgagctgagc tgagctgggg tgagctgggg tgagctgggg tgagctgggg     1740

tgagctgagc tgaactgggg tgagctgggc tgagctgggg tgagctgagc tgagctgggc     1800

tgagctgggg tgagctgggg tgagctgggg tgagctgagc tgagctaggg tgagctgagc     1860

tgagctaggg tgagctgagc tgagctgggg tgagctgagc tgagctgggg tgagctgagc     1920

tgagctgggg tgagctgagc tgagctgggg tgagctgagc tgagctgggg tgagcttggc     1980

tgagctgggg tgagctgggg tgagctgagc tggggtgagc tggggtaagc tgagctgagc     2040

tggggtgagc tgagctgagc tggggtgagc tggggtgagc tgagctgagc tgagctgggt     2100

gatctgagct gagctgagct gggtgagctg agctgagctg agctgggtga gctgagctga     2160

gctgagctga gctgggtgag ctgagctgag ctgagctgag ctgagctgag ctggggtgag     2220

ctgggctgag ctgagctgag ctggggtgag ctgagctgag ctgagctgag ctggggtgag     2280

ctgggctgag ctggggtgag ctgggctgag ctgagctggg tgagctgagc tgaactgagc     2340

tgagctgggt gagctgagct gagctgagct gggtgagctg agctgggctg agctgagctg     2400

ggtgagctga gctgaactga gctgagctgg gtgagctgag ctgagctgag ctgggtgagc     2460

tgagctgggg tgagctgagc tgagctgggg tgagctgagc tgagctgagc tgggtgagct     2520

gagctggggt gagctgagct gagctggggt gagctgagct gagctggggt gagctgagct     2580

gagctggggt gagctgagct gagctggggt gagctgagct agggtgaact gggctgggtg     2640

agctggagtg agctgagctg aggtgaactg gggtgagccg ggatgttttg agttgagctg     2700

gggtaagatg agctgaactg gggtaagatg ggatgagctg tggtgagggg agctggattg     2760

aactgagctg tgtgagctga gctggggtca gctgagcaag agtgagtaga gctggctggc     2820

cagaaccaga atcaattagg ctaagtgagc cagattgcgc tgggatcagc tgtactcaga     2880

tgagctggga tgaggtaggc tgggatgagc tgggctagct gacatggatt atgtgaggct     2940

gagctagcat gggctggcct agctgatgag ctaagcttga atgaacgggg ctgagctgga     3000

ctcagatgtg ctagactgag ctgtactgga tgatctggtg tagggtgatc tggactcaac     3060

tgggctggct gatgggatgc cccaggttga actaggctca gataagttag gctgagtagg     3120

gcctggttga gatggttcgg gatgagctgg gaaaagatgg actgggacca tgaactgggc     3180

tgagctgggt tgggagacca tgaattgagc tgaactgagt gcagctggga taaactgggt     3240

tgagctaaga atagactacc tgaattgtgc caaactgggc tgggatcaat tggaaattat     3300

caggatttag atgagccgga ctaaactatg ctgagctgga ctggttggat gtgttgaact     3360

ggcctgctgc tgggctggca tagctgagtt gaacttaaat gaggaaggat gagcaaggct     3420

agcctgcttg catagagctg aactttagcc tagcctgagc tggaccagcc tgagctgagt     3480

aggtctaaac tgagttaaaa atcaacaggg ataatttaac agctaattta acaagcctga     3540

ggtctgagat t                                                          3551


<210>  5
<211>  2484
<212>  DNA
<213>  Mus musculus

<400>  5
aagcttgctg agcaaaatta agggaacaag gttgagagcc ctagtaagcg aggctctaaa       60

aagcacagct gagctgagat gggtgggctt ctctgagtgc ttctaaaatg cgctaaactg      120

aggtgattac tctgaggtaa gcaaagctgg gcttgagcca aaatgaagta gactgtaatg      180

aactggaatg agctgggccg ctaagctaaa ctaggctggc ttaaccgaga tgagccaaac      240

tggaatgaac ttcattaatc taggttgaat agagctaaac tctactgcct acactggact      300

gttctgagct gagatgagct ggggtgagct cagctatgct acgctgtgtt ggggtgagct      360

gatctgaaat gagatactct ggagtagctg agatggggtg agatggggtg agctgagctg      420

ggctgagcta gactgagctg agctagggtg agctgagctg ggtgagctga gctaagctgg      480

ggtgagctga gctgagcttg gctgagctag ggtgagctgg gctgagctgg ggtgagctga      540

gctgagctgg ggtaagctgg gatgagctgg ggtgagctga gctgagctgg agtgagctga      600

gctgggctga gctggggtga gctgggctga gctgggctga gctgggctga gctggggtga      660

gctgagctgg ggtgagctga gctgagctgg ggtgagctga gctgagctgg ggtgagctgg      720

ggtgagctga gctggggtga gctgagctga gctggggtga gctgagctgg ggtgagctga      780

gctgagctgg ggtgagctga gctgagctga gctgagctga gctggggtga gctgagctga      840

gctgagctgg ggtgagctgg ggtgagctga gctgagctgg agtgagctga gctgggctga      900

gctggggtga gctgggctga gctggggtga gctgagctga gctgagctga gctggggtga      960

gctgagctga gctggggtga gctgagctgg ggtgagctgg gctgagctga gctgagctga     1020

gctgagctga gctgagctga gctgagctga gctgagctga gctgagctga gctgagctga     1080

gctgagctgg ggtgagctga gctgagctgg gctgagctgg ggtgagctgg gctgagctgg     1140

gctgagctgg gctgagctgg ggtgagctga gctggggtga gctgagctga gctgggctga     1200

gctgagctga gctggggtga gctgagctga gctggggtga gctgagctga gctgagctgg     1260

ggtgagctga gctgggctga gcagggctga gctggggtga gctgagctga gctggggtga     1320

gctgggctga gctgggctga gctgagctga gctgggctga gctgggctga gctgggctga     1380

gctgggctga gctgggctga gctggggtga gctgagctga gctggggtga gctggggtga     1440

gctgagctgg ggtgagctga gctggggtga gctgagctga gctggggtga gctgagctgg     1500

ggtgagctga gctgagctgg ggtgagctga gctgagctgg ggtgagctga gctagggtga     1560

actgggctgg gtgagctgga gtgagctgag ctgaggtgaa ctggggtgag ccgggatgtt     1620

ttgagttgag ctggggtaag atgagctgaa ctggggtaaa ctgggatgag ctgtggtgag     1680

cggagctgga ttgaactgag ctgtgtgagc tgagctgggg tcagctgagc aagagtgagt     1740

agagctggct ggccagaacc agaatcaatt aggctaagtg agccagattg tgctgggatc     1800

agctgtactc agatgagctg ggatgaggta ggctgggatg agctgggcta gctgacatgg     1860

attatgtgag gctgagctag catgggctgg cctagctgat gagctaagct tgaatgagcg     1920

gggctgagct ggactcagat gtgctagact gagctgtact ggatgatctg gtgtagggtg     1980

atctggactc aactgggctg gctgatggga tgcgccaggt tgaactaggc tcagataagt     2040

taggctgagt agggcctggt tgagatggtt cgggatgagc tgggaaaaga tggactcgga     2100

ccatgaactg ggctgagctg ggttgggaga ccatgaattg agctgaactg agtgcagctg     2160

ggataaactg ggttgagcta agaatagact acctgaattg tgccaaactc ggctgggatc     2220

aattggaaat tatcaggatt tagatgagcc ggactaaact atgctgagct ggactggttg     2280

gatgtgttga actggcctgc tgctgggctg gcatagctga gttgaactta aatgaggaag     2340

gctgagcaag gctagcctgc ttgcatagag ctgaacttta gcctagcctg agctggacca     2400

gcctgagctg agtaggtcta aactgagtta aaaatcaaca gggataattt aacagctaat     2460

ttaacaagcc tgaggtctga gatt                                            2484


<210>  6
<211>  4515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homology arm of targetting vector

<400>  6
aacctgggca aatgggagct tagcaacaat gtagggggct ggacctagac ttcctacaca       60

tgtgtaacag atgtgcagct tggtcttcat gtgtgtatta ccctaacatt tggagcagga      120

gctgtctctg actctgttgc ctgccattgg atccccttcc cctgcttggg ctgccttgtt      180

tggccttagt aggaaaggat gtgcttagtc ctgctgtgac ttgatgtccc taggcagaat      240

gataccccag gggggctccc catctctgag gagatgggca aagggtaatg gttggaggga      300

cttgtgaggc tgggactggg aggagagaaa ggagacagct gtaactggaa tgatgttaag      360

tgaacaaatg aatggataga ttagatagac agatagacag acagacagac agacagacag      420

acagacagac agacagacag atagaaagat agatagataa ggggaaaaag aaacgtagct      480

gagcaagcca gagagagcaa gccaaataag cagcattcct ccatgacttt tccttcagct      540

cctgcctatg agtctgcctt gacttccctc agtgattggt tgtaagttaa aaggtgaaat      600

aaaccctttc tttgacaagt tgcttttggt tctgattttt atcacagcaa gagaaaatca      660

aactagaaca aacatgtatt tttcctggca catgtccata gtaaggcaga aatgatcttc      720

agacctagac catagatact acagagagca gaagtgtaga taggtggact tactgtatga      780

ttgtaatcca agtaaatcta catagctaga gagctagagg aaaggccaaa gcttcctctg      840

ggaggtcaga tcctgtcgca ctgtagccaa taaggcatat tgcatcacag gaaaggacta      900

agacccaggc tggcaatagt gtctgtatct taactagatc tctctagtga gtgaggaagt      960

aaatttgtga gagcccagac tgtgggctcg gaaggtacct gccatgcccc tgttagtaac     1020

tgagtactac agcaggagca ggtgttctct agaaagcctg agacaactct acttcttctc     1080

tcaagagacc acctaataca ggcctgagag aacagactct ggaaatagat gggacttacg     1140

gagctaagat ctagagctca tctacagagc agaatcccag ccaagagaac aaagaatact     1200

gactctctcc tgttccctac tcctagagtt ctaaaacaca ctatagggaa gggagcctct     1260

agacctccgt ccattcccca tcttgctcat tccatcttcc catgtcccca ggtctccaag     1320

ccacagacac cacctttcct attcacccac ctttctgtgt ccctaggtcc ccaggccata     1380

gtcacctccc cccacacccc gctcaccctg ccccatctat gcccctagat gcttacttac     1440

cagagtcttt tgtctgacgt ggggctacaa gcatctatgc tccctaagca cctactgctg     1500

acctgtagga cccagctctg aaccaactca tataagtaaa tacagactct cccctgtctt     1560

aggatggccc cctgggtcag gaggagacca ctgccaagga accttctctt agagcactga     1620

actcctcccc tgtaccactt aggacagacc tgagacctat tattactgat taccagagct     1680

ctggcagtga ccacggagga gatagatcca ccctggacac aggaaacaca gcaccagaga     1740

tactgcttca tcacaacagt agagtgacac tttagacttt aatttgggtc actttcctgc     1800

tgtagaggtg ggatcagaaa gcaaagagca gtatgagtgc ctgataggca cccaagtaca     1860

ctatagagta ctcatggtga ataaggtacc tccatggctt cccagggagg ggcactgccc     1920

cacccccacc atcacagacc tttctccata gttgataact cagacacaag tgaatgacag     1980

atggacctcc atctgctctt attttaaaaa gaagacaaac cccacaggct cgagaacttt     2040

agcgactgtt ttgagagaaa tcattggtcc ctgactcaag agatgactgg cagattgggg     2100

atcagaatac ccatactctg tggctagtgt gaggtttaag cctcagagtc cctgtggtct     2160

ctgactggtg caaggttttg actaagcgga gcaccacagt gctaactggg accacggtga     2220

cacgtggctc aacaaaaacc ttctgtttgg agctctccag gggcagcctg agctatgagg     2280

aagtagagag gcttgagaaa tctgaggaag aaaagagtag atctgagagg aaaggtagct     2340

ttctggaggt caggagacag tgcagagaag aacgagttac tgtggacagg tcttagatgg     2400

ggaaagaatg agcaaatgca agcatcagaa gggtggatgc aatgtcctgc caaggactta     2460

ccaagaggat ccccggacag agcaggcagg tggagttgac tgagaggaca ggataggtgc     2520

aggtccctct cttgtttcct ttctccttct cctgtttcct tcttctcttg tcacaggtct     2580

cactatgcta gccaaggcta gcctgaaaga ttaccatcct acagatgggc ccatccagtt     2640

gaattaaggt ggagatctct ccaaacatct gagtttctga ggcttggatg ccactgggga     2700

cgccaaggga ctttgggatg ggtttggttg gccccagatg aagggctact tcactgggtc     2760

tataattact ctgatgtcta ggaccagggg gctcaggtca ctcaggtcag gtgagtcctg     2820

catctgggga ctgtggggtt caggtggcct aaggcaggat gtggagagag ttttagtata     2880

ggaacagagg cagaacagag actgtgctac tggtacttcg atgtctgggg cacagggacc     2940

acggtcaccg tctcctcagg taagctggct tttttctttc tgcacattcc attctgaaac     3000

gggaaaagat attctcagat ctccccatgt caggccatct gccacactct gcatgctgca     3060

gaagcttttc tgtaaggata gggtcttcac tcccaggaaa agaggcagtc agaggctagc     3120

tgcctgtgga acagtgacaa tcatggaaaa taggcattta cattgttagg ctacatgggt     3180

agatgggttt ttgtacaccc actaaagggg tctatgatag tgtgactact ttgactactg     3240

gggccaaggc accactctca cagtctcctc aggtgagtcc ttacaacctc tctcttctat     3300

tcagcttaaa tagattttac tgcatttgtt gggggggaaa tgtgtgtatc tgaatttcag     3360

gtcatgaagg actagggaca ccttgggagt cagaaagggt cattgggagc cctggctgac     3420

gcagacagac atcctcagct cccatacttc atggccagag atttataggg atcctggcca     3480

gcattgccgc taggtccctc tcttctatgc tttctttgtc cctcactggc ctccatctga     3540

gatcatcctg gagccctagc caaggatcat ttattgtcag gggtctaatc attgttgtca     3600

caatgtgcct ggtttgctta ctggggccaa gggactctgg tcactgtctc tgcaggtgag     3660

tcctaacttc tcccattcta aatgcatgtt ggggggattc tgggccttca ggaccaagat     3720

tctctgcaaa cgggaatcaa gattcaaccc ctttgtccca aagttgagac atgggtctgg     3780

gtcagggact ctctgcctgc tggtctgtgg tgacattaga actgaagtat gatgaaggat     3840

ctgccagaac tgaagcttga agtctgaggc agaatcttgt ccagggtcta tcggactctt     3900

gtgagaatta ggggctgaca gttgatggtg acaatttcag ggtcagtgac tgtctggttt     3960

ctctgaggtg aggctggaat ataggtcacc ttgaagacta aagaggggtc caggggcttc     4020

tgcacaggca gggaacagaa tgtggaacaa tgacttgaat ggttgattct tgtgtgacac     4080

caggaattgg cataatgtct gagttgccca ggggtgattc tagtcagact ctggggtttt     4140

tgtcgggtat agaggaaaaa tccactattg tgattactat gctatggact actggggtca     4200

aggaacctca gtcaccgtct cctcaggtaa gaatggcctc tccaggtctt tatttttaac     4260

ctttgttatg gagttttctg agcattgcag actaatcttg gatatttgtc cctgagggag     4320

ccggctgaga gaagttggga aataaactgt ctagggatct cagagccttt aggacagatt     4380

atctccacat ctttgaaaaa ctaagaatct gtgtgatggt gttggtggag tccctggatg     4440

atgggatagg gactttggag gctcatttga agaagatgct aaaacaatcc tatggctgga     4500

gggatagttg gggct                                                      4515


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide HV2-5

<400>  7
agatcacctt gaaggagtct ggtcc                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide HV4-4

<400>  8
tggtgaagcc ttcggagacc ctgtc                                             25


<210>  9
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide HV1-3

<400>  9
cactagctat gctatgcatt gggtg                                             25


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide HV1-2

<400>  10
atggatcaac cctaacagtg gtggc                                             25


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide HV6-1

<400>  11
ggaaggacat actacaggtc caagt                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide C

<400>  12
taggtacttg ccccctgtcc tcagt                                             25


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide KV1-9

<400>  13
agcccagtgt gttccgtaca gcctg                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide KV1-8

<400>  14
atcctcattc tctgcatcta cagga                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide KV1-6

<400>  15
ggtaaggatg gagaacactg gcagt                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide KV1-5

<400>  16
ttagtagctg gttggcctgg tatca                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide Ck

<400>  17
ctttgctgtc ctgatcagtc caact                                             25


