                         SEQUENCE LISTING

<110>  Genmab A/S
 
<120>  Human antibody drug conjugates against tissue factor

<130>  P/65.WO

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  homo sapiens

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Val Ser Asn Asp 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Trp Tyr Asp Gly Val Asn Lys Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Pro Gly Thr Phe Tyr Gly Leu Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  2

Gly Phe Thr Val Ser Asn Asp Gly 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  3

Ile Trp Tyr Asp Gly Val Asn Lys 
1               5               


<210>  4
<211>  12
<212>  PRT
<213>  homo sapiens

<400>  4

Ala Arg Arg Pro Gly Thr Phe Tyr Gly Leu Asp Val 
1               5                   10          


<210>  5
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Asp Tyr Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Trp Gly Tyr Tyr Leu Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  6
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  6

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  7

Ile Ser Gly Ser Gly Asp Tyr Thr 
1               5               


<210>  8
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  8

Ala Arg Ser Pro Trp Gly Tyr Tyr Leu Asp Ser 
1               5                   10      


<210>  9
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Ser Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Tyr Phe Leu Leu Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  10
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  10

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  11

Ile Ser Gly Ser Gly Asp Ser Thr 
1               5               


<210>  12
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  12

Ala Lys Asp Gly Tyr Phe Leu Leu Trp Tyr Phe Asp Leu 
1               5                   10              


<210>  13
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Ser Gly Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ala Pro Trp Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  14
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  14

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  15

Ile Ser Gly Ser Gly Gly Thr Thr 
1               5               


<210>  16
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  16

Ala Lys Ala Pro Trp Thr Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  17
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  17

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Pro Trp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  18
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  18

Gly Phe Thr Phe Asn Asn Tyr Ala 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  19

Ile Ser Gly Ser Gly Gly Arg Thr 
1               5               


<210>  20
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  20

Ala Lys Thr Pro Trp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  21
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  21

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Ala Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Thr Pro Trp Gly Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Leu Val Ala Val Ser Ser 
        115             


<210>  22
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  22

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  23

Ile Ser Gly Ser Gly Val Thr Thr 
1               5               


<210>  24
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  24

Ala Lys Thr Pro Trp Gly Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  25
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asn Asp Gly Tyr Asn Asp Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gln Leu Gly Arg Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  26
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  26

Gly Phe Thr Phe Ser Arg Tyr Ala 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  27

Ile Ser Asn Asp Gly Tyr Asn Asp 
1               5               


<210>  28
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  28

Ala Arg Asp Gly Gln Leu Gly Arg Gly Tyr Phe Asp Tyr 
1               5                   10              


<210>  29
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Pro Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Ser Asn Asp Gly Tyr Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Gln Leu Gly Arg Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  30

Gly Phe Thr Phe Ser Ile Tyr Ala 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  31

Val Ser Asn Asp Gly Tyr Asn Lys 
1               5               


<210>  32
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  32

Ala Arg Asp Gly Gln Leu Gly Arg Gly Tyr Phe Asp Tyr 
1               5                   10              


<210>  33
<211>  118
<212>  PRT
<213>  homo sapiens

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Asn Asn Tyr 
            20                  25                  30          


Pro Ile Phe Trp Val Arg Gln Ala Pro Gly Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Leu Gly Ile Thr Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Asp Asp Leu Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Ser Val Ser Ser 
        115             


<210>  34
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  34

Gly Gly Ser Phe Asn Asn Tyr Pro 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  35

Ile Ile Pro Ile Leu Gly Ile Thr 
1               5               


<210>  36
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  36

Ala Gly Gly Asp Asp Leu Asp Ala Phe Asp Ile 
1               5                   10      


<210>  37
<211>  120
<212>  PRT
<213>  homo sapiens

<400>  37

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Asn Arg Tyr 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Trp Val 
        35                  40                  45              


Ala Val Ile Ser Asn Asp Gly Ile Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp His Thr Met Val Arg Gly Ala Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  38
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  38

Gly Phe Thr Phe Asn Arg Tyr Ala 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  39

Ile Ser Asn Asp Gly Ile Asn Lys 
1               5               


<210>  40
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  40

Ala Arg Asp His Thr Met Val Arg Gly Ala Phe Asp Tyr 
1               5                   10              


<210>  41
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  41

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  42
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  42

Gln Ser Val Ser Ser Ser Tyr 
1               5           


<210>  43
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  43

Gly Ala Ser 
1           


<210>  44
<211>  8
<212>  PRT
<213>  homo sapiens

<400>  44

Gln Gln Tyr Gly Ser Ser Leu Thr 
1               5               


<210>  45
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  46
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  46

Gln Gly Ile Ser Ser Arg 
1               5       


<210>  47
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  47

Ala Ala Ser 
1           


<210>  48
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  48

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  49
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  50
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  50

Gln Ser Val Arg Ser Ser Tyr 
1               5           


<210>  51
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  51

Gly Ala Ser 
1           


<210>  52
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  52

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  53
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  53

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  54
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  54

Gln Ser Val Gly Ser Ser Ser 
1               5           


<210>  55
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  55

Gly Ala Ser 
1           


<210>  56
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  56

Gln Gln Tyr Gly Ser Ser Pro Arg Thr 
1               5                   


<210>  57
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Arg 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  58
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  58

Gln Gly Ile Ser Ser Arg 
1               5       


<210>  59
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  59

Ala Ala Ser 
1           


<210>  60
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  60

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  61
<211>  108
<212>  PRT
<213>  homo sapiens

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  62
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  62

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  63
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  63

Ala Ala Ser 
1           


<210>  64
<211>  10
<212>  PRT
<213>  homo sapiens

<400>  64

Gln Gln Tyr Asn Ser Tyr Pro Leu Tyr Thr 
1               5                   10  


<210>  65
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  65

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  66

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  67
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  67

Asp Ala Ser 
1           


<210>  68
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  68

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  69
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  69

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  70

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  71
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  71

Asp Ala Ser 
1           


<210>  72
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  72

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  73
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  74
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  74

Gln Gly Ile Ser Ser Trp 
1               5       


<210>  75
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  75

Ala Ala Ser 
1           


<210>  76
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  76

Gln Gln Tyr Asn Ser Tyr Pro Tyr Thr 
1               5                   


<210>  77
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  77

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  78
<211>  6
<212>  PRT
<213>  homo sapiens

<400>  78

Gln Ser Val Ser Ser Tyr 
1               5       


<210>  79
<211>  3
<212>  PRT
<213>  homo sapiens

<400>  79

Asp Ala Ser 
1           


<210>  80
<211>  9
<212>  PRT
<213>  homo sapiens

<400>  80

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  81
<211>  327
<212>  PRT
<213>  homo sapiens

<400>  81

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  82
<211>  315
<212>  PRT
<213>  homo sapiens

<400>  82

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            100                 105                 110         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        115                 120                 125             


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
    130                 135                 140                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
145                 150                 155                 160 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                165                 170                 175     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            180                 185                 190         


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        195                 200                 205             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
    210                 215                 220                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
225                 230                 235                 240 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                245                 250                 255     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            260                 265                 270         


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
        275                 280                 285             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    290                 295                 300                 


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
305                 310                 315 


