                         SEQUENCE LISTING

<110>  Levin, Steven D.
       Ostrander, Craig D.
       Moore, Margaret D.
 
<120>  DIMERIC FUSION PROTEINS AND RELATED COMPOSITIONS AND METHODS

<130>  Z01001 PCT

<150>  61/352873 

<151>  06/09/10

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (349)..(349)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  n is a or g

<400>  1
atgcgctggt gtctcctcct gatctgggcc caggggctga ggcaggctcc cctcgcctca       60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct      120

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag      180

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc      240

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg      300

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggnc gtacactggg      360

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt      420

ccattgcttg gagccatggc cgcgacgctg gtggtcatct gcacagcagt catcgtggtg      480

gtcgcgttga ctagaaagaa gaaagccctc agaatccatt ctgtggaagg tgacctcagg      540

agaaaatcag ctggacagga ggaatggagc cccagtgctc cctcaccccc aggaagctgt      600

gtccaggcag aagctgcacc tgctgggctc tgtggagagc agcggggaga ggactgtgcc      660

gagctgcatg actacttcaa tgtcctgagt tacagaagcc tgggtaactg cagcttcttc      720

acagagactg gttag                                                       735


<210>  2
<211>  244
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa is Thr or Ala

<400>  2

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Xaa Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Leu Leu Gly 
    130                 135                 140                 


Ala Met Ala Ala Thr Leu Val Val Ile Cys Thr Ala Val Ile Val Val 
145                 150                 155                 160 


Val Ala Leu Thr Arg Lys Lys Lys Ala Leu Arg Ile His Ser Val Glu 
                165                 170                 175     


Gly Asp Leu Arg Arg Lys Ser Ala Gly Gln Glu Glu Trp Ser Pro Ser 
            180                 185                 190         


Ala Pro Ser Pro Pro Gly Ser Cys Val Gln Ala Glu Ala Ala Pro Ala 
        195                 200                 205             


Gly Leu Cys Gly Glu Gln Arg Gly Glu Asp Cys Ala Glu Leu His Asp 
    210                 215                 220                 


Tyr Phe Asn Val Leu Ser Tyr Arg Ser Leu Gly Asn Cys Ser Phe Phe 
225                 230                 235                 240 


Thr Glu Thr Gly 
                


<210>  3
<211>  726
<212>  DNA
<213>  Mus musculus

<400>  3
atgcatggct ggctgctcct ggtctgggtc caggggctga tacaggctgc cttcctcgct       60

acaggagcca cagcaggcac gatagataca aagaggaaca tctctgcaga ggaaggtggc      120

tctgtcatct tacagtgtca cttctcctct gacacagctg aagtgaccca agtcgactgg      180

aagcagcagg accagcttct ggccatttat agtgttgacc tggggtggca tgtcgcttca      240

gtcttcagtg atcgggtggt cccaggcccc agcctaggcc tcaccttcca gtctctgaca      300

atgaatgaca cgggagagta cttctgtacc tatcatacgt atcctggtgg gatttacaag      360

gggagaatat tcctgaaggt ccaagaaagc tcagtggctc agttccagac tgccccgctt      420

ggaggaacca tggctgctgt gctgggactc atttgcttaa tggtcacagg agtgactgta      480

ctggctagaa agaagtctat tagaatgcat tctatagaaa gtggccttgg gagaacagaa      540

gcggagccac aggaatggaa cctgaggagt ctctcatccc ctggaagccc tgtccagaca      600

caaactgccc ctgctggtcc ctgtggagag caggcagaag atgactatgc tgacccacag      660

gaatacttta atgtcctgag ctacagaagc ctagagagct tcattgctgt atcgaagact      720

ggctaa                                                                 726


<210>  4
<211>  241
<212>  PRT
<213>  Mus musculus

<400>  4

Met His Gly Trp Leu Leu Leu Val Trp Val Gln Gly Leu Ile Gln Ala 
1               5                   10                  15      


Ala Phe Leu Ala Thr Gly Ala Thr Ala Gly Thr Ile Asp Thr Lys Arg 
            20                  25                  30          


Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe 
        35                  40                  45              


Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp 
    50                  55                  60                  


Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser 
65                  70                  75                  80  


Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe 
                85                  90                  95      


Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His 
            100                 105                 110         


Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln 
        115                 120                 125             


Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Pro Leu Gly Gly Thr Met 
    130                 135                 140                 


Ala Ala Val Leu Gly Leu Ile Cys Leu Met Val Thr Gly Val Thr Val 
145                 150                 155                 160 


Leu Ala Arg Lys Lys Ser Ile Arg Met His Ser Ile Glu Ser Gly Leu 
                165                 170                 175     


Gly Arg Thr Glu Ala Glu Pro Gln Glu Trp Asn Leu Arg Ser Leu Ser 
            180                 185                 190         


Ser Pro Gly Ser Pro Val Gln Thr Gln Thr Ala Pro Ala Gly Pro Cys 
        195                 200                 205             


Gly Glu Gln Ala Glu Asp Asp Tyr Ala Asp Pro Gln Glu Tyr Phe Asn 
    210                 215                 220                 


Val Leu Ser Tyr Arg Ser Leu Glu Ser Phe Ile Ala Val Ser Lys Thr 
225                 230                 235                 240 


Gly 
    


<210>  5
<211>  1494
<212>  DNA
<213>  Artificial

<220>
<223>  B7R1 Fc5 Barbell

<400>  5
atgcgctggt gtctcctcct gatctgggcc caggggctga ggcaggctcc cctcgcctca       60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct      120

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag      180

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc      240

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg      300

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggac gtacactggg      360

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt      420

ccagagccca aatcttcaga caaaactcac acatgcccac cgtgcccagc acctgaagcc      480

gagggggcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      540

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      600

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      660

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      720

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccatcctc catcgagaaa      780

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc      840

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      900

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      960

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1020

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1080

cactacacgc agaagagcct ctccctgtct ccgggtaaag gtggtgggtc cggaatgatg     1140

acaggcacaa tagaaacaac ggggaacatt tctgcagaga aaggtggctc tatcatctta     1200

caatgtcacc tctcctccac cacggcacaa gtgacccagg tcaactggga gcagcaggac     1260

cagcttctgg ccatttgtaa tgctgacttg gggtggcaca tctccccatc cttcaaggat     1320

cgagtggccc caggtcccgg cctgggcctc accctccagt cgctgaccgt gaacgataca     1380

ggggagtact tctgcatcta tcacacctac cctgatggga cgtacactgg gagaatcttc     1440

ctggaggtcc tagaaagctc agtggctgag cacggtgcca ggttccagat tcca           1494


<210>  6
<211>  498
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1 Fc5 Barbell

<400>  6

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys 
    130                 135                 140                 


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
145                 150                 155                 160 


Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser 
                245                 250                 255     


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Pro Gly Lys Gly Gly Gly Ser Gly Met Met Thr Gly Thr Ile 
    370                 375                 380                 


Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu 
385                 390                 395                 400 


Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp 
                405                 410                 415     


Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp 
            420                 425                 430         


His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu 
        435                 440                 445             


Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe 
    450                 455                 460                 


Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe 
465                 470                 475                 480 


Leu Glu Val Leu Glu Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln 
                485                 490                 495     


Ile Pro 
        


<210>  7
<211>  1539
<212>  DNA
<213>  Artificial

<220>
<223>  B7R1 Fc5 Tandem

<400>  7
atgcgctggt gtctcctcct gatctgggcc caggggctga ggcaggctcc cctcgcctca       60

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct      120

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag      180

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc      240

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg      300

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggac gtacactggg      360

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt      420

ccaggcggtt cgggctcagg atcgggaggt tcaggttccg gtggttctgg tggtgggtcc      480

ggaatgatga caggcacaat agaaacaacg gggaacattt ctgcagagaa aggtggctct      540

atcatcttac aatgtcacct ctcctccacc acggcacaag tgacccaggt caactgggag      600

cagcaggacc agcttctggc catttgtaat gctgacttgg ggtggcacat ctccccatcc      660

ttcaaggatc gagtggcccc aggtcccggc ctgggcctca ccctccagtc gctgaccgtg      720

aacgatacag gggagtactt ctgcatctat cacacctacc ctgatgggac gtacactggg      780

agaatcttcc tggaggtcct agaaagctca gtggctgagc acggtgccag gttccagatt      840

ccagagccca aatcttcaga caaaactcac acatgcccac cgtgcccagc acctgaagcc      900

gagggggcac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      960

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag     1020

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag     1080

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg     1140

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccatcctc catcgagaaa     1200

accatctcca aagccaaagg gcagccccga gagccacagg tgtacaccct gcccccatcc     1260

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1320

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1380

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1440

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1500

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1539


<210>  8
<211>  513
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1 Fc5 Tandem

<400>  8

Met Arg Trp Cys Leu Leu Leu Ile Trp Ala Gln Gly Leu Arg Gln Ala 
1               5                   10                  15      


Pro Leu Ala Ser Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn 
            20                  25                  30          


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
        35                  40                  45              


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
    50                  55                  60                  


Leu Leu Ala Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
65                  70                  75                  80  


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
                85                  90                  95      


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
            100                 105                 110         


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
        115                 120                 125             


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Gly Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu 
                165                 170                 175     


Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala 
            180                 185                 190         


Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile 
        195                 200                 205             


Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg 
    210                 215                 220                 


Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val 
225                 230                 235                 240 


Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly 
                245                 250                 255     


Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala 
            260                 265                 270         


Glu His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys Ser Ser Asp Lys 
        275                 280                 285             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                325                 330                 335     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            500                 505                 510         


Lys 
    


<210>  9
<211>  1467
<212>  DNA
<213>  Artificial

<220>
<223>  mB7R1 mFc2 Barbell

<400>  9
atgcatggct ggctgctcct ggtctgggtc caggggctga tacaggctgc cttcctcgct       60

acaggagcca cagcaggcac gatagataca aagaggaaca tctctgcaga ggaaggtggc      120

tctgtcatct tacagtgtca cttctcctct gacacagctg aagtgaccca agtcgactgg      180

aagcagcagg accagcttct ggccatttat agtgttgacc tggggtggca tgtcgcttca      240

gtcttcagtg atcgggtggt cccaggcccc agcctaggcc tcaccttcca gtctctgaca      300

atgaatgaca cgggagagta cttctgtacc tatcatacgt atcctggtgg gatttacaag      360

gggagaatat tcctgaaggt ccaagaaagc tcagtggctc agttccagac tgccgagccc      420

agatctccca caatcaagcc ctgtcctcca tgcaaatgcc cagcacctaa cctcgagggt      480

ggaccatccg tcttcatctt ccctccaaag atcaaggatg tactcatgat ctccctgagc      540

cccatagtca catgtgtggt ggtggatgtg agcgaggatg acccagatgt ccagatcagc      600

tggtttgtga acaacgtgga agtacacaca gctcagacac aaacccatag agaggattac      660

aacagtactc tccgggtggt cagtgccctc cccatccagc accaggactg gatgagtggc      720

aaagctttcg catgcgcggt caacaacaaa gacctcccag cgcccatcga gagaaccatc      780

tcaaaaccca aagggtcagt aagagctcca caggtatatg tcttgcctcc accagaagaa      840

gagatgacta agaaacaggt cactctgacc tgcatggtca cagacttcat gcctgaagac      900

atttacgtgg agtggaccaa caacgggaaa acagagctaa actacaagaa cactgaacca      960

gtcctggact ctgatggttc ttacttcatg tacagcaagc tgagagtgga aaagaagaac     1020

tgggtggaaa gaaatagcta ctcctgttca gtggtccacg agggtctgca caatcaccac     1080

acgactaaga gcttctcccg gactccgggt aaaggtggtg ggtccggagg cacgatagat     1140

acaaagagga acatctctgc agaggaaggt ggctctgtca tcttacagtg tcacttctcc     1200

tctgacacag ctgaagtgac ccaagtcgac tggaagcagc aggaccagct tctggccatt     1260

tatagtgttg acctggggtg gcatgtcgct tcagtcttca gtgatcgggt ggtcccaggc     1320

cccagcctag gcctcacctt ccagtctctg acaatgaatg acacgggaga gtacttctgt     1380

acctatcata cgtatcctgg tgggatttac aaggggagaa tattcctgaa ggtccaagaa     1440

agctcagtgg ctcagttcca gactgcc                                         1467


<210>  10
<211>  489
<212>  PRT
<213>  Artificial

<220>
<223>  mB7R1 mFc2 Barbell

<400>  10

Met His Gly Trp Leu Leu Leu Val Trp Val Gln Gly Leu Ile Gln Ala 
1               5                   10                  15      


Ala Phe Leu Ala Thr Gly Ala Thr Ala Gly Thr Ile Asp Thr Lys Arg 
            20                  25                  30          


Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe 
        35                  40                  45              


Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp 
    50                  55                  60                  


Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser 
65                  70                  75                  80  


Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe 
                85                  90                  95      


Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His 
            100                 105                 110         


Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln 
        115                 120                 125             


Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Glu Pro Arg Ser Pro Thr 
    130                 135                 140                 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Glu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
                165                 170                 175     


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
            180                 185                 190         


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
        195                 200                 205             


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
    210                 215                 220                 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
225                 230                 235                 240 


Lys Ala Phe Ala Cys Ala Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
            260                 265                 270         


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
        275                 280                 285             


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
    290                 295                 300                 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
                325                 330                 335     


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
            340                 345                 350         


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
        355                 360                 365             


Pro Gly Lys Gly Gly Gly Ser Gly Gly Thr Ile Asp Thr Lys Arg Asn 
    370                 375                 380                 


Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe Ser 
385                 390                 395                 400 


Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp Gln 
                405                 410                 415     


Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser Val 
            420                 425                 430         


Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe Gln 
        435                 440                 445             


Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His Thr 
    450                 455                 460                 


Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln Glu 
465                 470                 475                 480 


Ser Ser Val Ala Gln Phe Gln Thr Ala 
                485                 


<210>  11
<211>  1527
<212>  DNA
<213>  Artificial

<220>
<223>  mB7R1 mFc2 Tandem

<400>  11
atgcatggct ggctgctcct ggtctgggtc caggggctga tacaggctgc cttcctcgct       60

acaggagcca cagcaggcac gatagataca aagaggaaca tctctgcaga ggaaggtggc      120

tctgtcatct tacagtgtca cttctcctct gacacagctg aagtgaccca agtcgactgg      180

aagcagcagg accagcttct ggccatttat agtgttgacc tggggtggca tgtcgcttca      240

gtcttcagtg atcgggtggt cccaggcccc agcctaggcc tcaccttcca gtctctgaca      300

atgaatgaca cgggagagta cttctgtacc tatcatacgt atcctggtgg gatttacaag      360

gggagaatat tcctgaaggt ccaagaaagc tcagtggctc agttccagac tgccggcggt      420

tcgggctcag gatcgggagg ttcaggttcc ggtggttctg gtggtgggtc cggaggcacg      480

atagatacaa agaggaacat ctctgcagag gaaggtggct ctgtcatctt acagtgtcac      540

ttctcctctg acacagctga agtgacccaa gtcgactgga agcagcagga ccagcttctg      600

gccatttata gtgttgacct ggggtggcat gtcgcttcag tcttcagtga tcgggtggtc      660

ccaggcccca gcctaggcct caccttccag tctctgacaa tgaatgacac gggagagtac      720

ttctgtacct atcatacgta tcctggtggg atttacaagg ggagaatatt cctgaaggtc      780

caagaaagct cagtggctca gttccagact gccgagccca gatctcccac aatcaagccc      840

tgtcctccat gcaaatgccc agcacctaac ctcgagggtg gaccatccgt cttcatcttc      900

cctccaaaga tcaaggatgt actcatgatc tccctgagcc ccatagtcac atgtgtggtg      960

gtggatgtga gcgaggatga cccagatgtc cagatcagct ggtttgtgaa caacgtggaa     1020

gtacacacag ctcagacaca aacccataga gaggattaca acagtactct ccgggtggtc     1080

agtgccctcc ccatccagca ccaggactgg atgagtggca aagctttcgc atgcgcggtc     1140

aacaacaaag acctcccagc gcccatcgag agaaccatct caaaacccaa agggtcagta     1200

agagctccac aggtatatgt cttgcctcca ccagaagaag agatgactaa gaaacaggtc     1260

actctgacct gcatggtcac agacttcatg cctgaagaca tttacgtgga gtggaccaac     1320

aacgggaaaa cagagctaaa ctacaagaac actgaaccag tcctggactc tgatggttct     1380

tacttcatgt acagcaagct gagagtggaa aagaagaact gggtggaaag aaatagctac     1440

tcctgttcag tggtccacga gggtctgcac aatcaccaca cgactaagag cttctcccgg     1500

actccgggta aaggtggtgg gtccgga                                         1527


<210>  12
<211>  509
<212>  PRT
<213>  Artificial

<220>
<223>  mB7R1 mFc2 Tandem

<400>  12

Met His Gly Trp Leu Leu Leu Val Trp Val Gln Gly Leu Ile Gln Ala 
1               5                   10                  15      


Ala Phe Leu Ala Thr Gly Ala Thr Ala Gly Thr Ile Asp Thr Lys Arg 
            20                  25                  30          


Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile Leu Gln Cys His Phe 
        35                  40                  45              


Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp Trp Lys Gln Gln Asp 
    50                  55                  60                  


Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly Trp His Val Ala Ser 
65                  70                  75                  80  


Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser Leu Gly Leu Thr Phe 
                85                  90                  95      


Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr Phe Cys Thr Tyr His 
            100                 105                 110         


Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile Phe Leu Lys Val Gln 
        115                 120                 125             


Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Gly Gly Ser Gly Ser Gly 
    130                 135                 140                 


Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 
145                 150                 155                 160 


Ile Asp Thr Lys Arg Asn Ile Ser Ala Glu Glu Gly Gly Ser Val Ile 
                165                 170                 175     


Leu Gln Cys His Phe Ser Ser Asp Thr Ala Glu Val Thr Gln Val Asp 
            180                 185                 190         


Trp Lys Gln Gln Asp Gln Leu Leu Ala Ile Tyr Ser Val Asp Leu Gly 
        195                 200                 205             


Trp His Val Ala Ser Val Phe Ser Asp Arg Val Val Pro Gly Pro Ser 
    210                 215                 220                 


Leu Gly Leu Thr Phe Gln Ser Leu Thr Met Asn Asp Thr Gly Glu Tyr 
225                 230                 235                 240 


Phe Cys Thr Tyr His Thr Tyr Pro Gly Gly Ile Tyr Lys Gly Arg Ile 
                245                 250                 255     


Phe Leu Lys Val Gln Glu Ser Ser Val Ala Gln Phe Gln Thr Ala Glu 
            260                 265                 270         


Pro Arg Ser Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
        275                 280                 285             


Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
    290                 295                 300                 


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
305                 310                 315                 320 


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
                325                 330                 335     


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
            340                 345                 350         


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
        355                 360                 365             


Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala Val Asn Asn Lys Asp 
    370                 375                 380                 


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
385                 390                 395                 400 


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
                405                 410                 415     


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
            420                 425                 430         


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
        435                 440                 445             


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
    450                 455                 460                 


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
465                 470                 475                 480 


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
                485                 490                 495     


Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Ser Gly 
            500                 505                 


<210>  13
<211>  1518
<212>  DNA
<213>  Artificial

<220>
<223>  B7R1[G25-P141] Fc5 Barbell (otPA leader sequence)>

<400>  13
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagaggcac aatagaaaca      120

acggggaaca tttctgcaga gaaaggtggc tctatcatct tacaatgtca cctctcctcc      180

accacggcac aagtgaccca ggtcaactgg gagcagcagg accagcttct ggccatttgt      240

aatgctgact tggggtggca catctcccca tccttcaagg atcgagtggc cccaggtccc      300

ggcctgggcc tcaccctcca gtcgctgacc gtgaacgata caggggagta cttctgcatc      360

tatcacacct accctgatgg gacgtacact gggagaatct tcctggaggt cctagaaagc      420

tcagtggctg agcacggtgc caggttccag attccagagc ccaaatcttc agacaaaact      480

cacacatgcc caccgtgccc agcacctgaa gccgaggggg caccgtcagt cttcctcttc      540

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      600

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      660

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      720

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      780

tccaacaaag ccctcccatc ctccatcgag aaaaccatct ccaaagccaa agggcagccc      840

cgagagccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc      900

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc      960

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1020

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1080

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1140

tctccgggta aaggtggtgg gtccggaggt acaattgaaa cgacaggcaa tatatctgcc     1200

gagaagggtg gctcgatcat attacaatgc cacctctcat ccaccactgc acaagtaacc     1260

caggtcaatt gggaacagca ggatcagctg ctggccatct gtaacgctga cttgggatgg     1320

cacatttccc catcgttcaa agatcgagtc gccccaggcc ccggcctcgg cctcacactc     1380

cagtctctga ccgtcaacga tacaggcgag tacttttgca tatatcacac ttaccctgac     1440

gggacctaca ctggtagaat cttcctagag gtcctagaga gctcagtcgc tgagcatggg     1500

gctagattcc agatccca                                                   1518


<210>  14
<211>  506
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1[G25-P141] Fc5 Barbell (otPA leader sequence)

<400>  14

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
        35                  40                  45              


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
    50                  55                  60                  


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
65                  70                  75                  80  


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
                85                  90                  95      


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
            100                 105                 110         


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
        115                 120                 125             


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
    130                 135                 140                 


His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys Ser Ser Asp Lys Thr 
145                 150                 155                 160 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
                165                 170                 175     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            180                 185                 190         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        195                 200                 205             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    210                 215                 220                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
225                 230                 235                 240 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                245                 250                 255     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr 
            260                 265                 270         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        275                 280                 285             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    290                 295                 300                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
305                 310                 315                 320 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                325                 330                 335     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala 
385                 390                 395                 400 


Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr 
                405                 410                 415     


Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala 
            420                 425                 430         


Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp 
        435                 440                 445             


Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr 
    450                 455                 460                 


Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp 
465                 470                 475                 480 


Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val 
                485                 490                 495     


Ala Glu His Gly Ala Arg Phe Gln Ile Pro 
            500                 505     


<210>  15
<211>  1518
<212>  DNA
<213>  Artificial

<220>
<223>  B7R1[G25-P141] C69Y Fc5 Barbell (otPA leader sequence)

<400>  15
atggatgcaa tgaagagagg gctctgctgt gtgctgctgc tgtgtggcgc cgtcttcgtt       60

tcgctcagcc aggaaatcca tgccgagttg agacgcttcc gtagaggcac aatagaaaca      120

acggggaaca tttctgcaga gaaaggtggc tctatcatct tacaatgtca cctctcctcc      180

accacggcac aagtgaccca ggtcaactgg gagcagcagg accagcttct ggccatttat      240

aatgctgact tggggtggca catctcccca tccttcaagg atcgagtggc cccaggtccc      300

ggcctgggcc tcaccctcca gtcgctgacc gtgaacgata caggggagta cttctgcatc      360

tatcacacct accctgatgg gacgtacact gggagaatct tcctggaggt cctagaaagc      420

tcagtggctg agcacggtgc caggttccag attccagagc ccaaatcttc agacaaaact      480

cacacatgcc caccgtgccc agcacctgaa gccgaggggg caccgtcagt cttcctcttc      540

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg      600

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag      660

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc      720

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc      780

tccaacaaag ccctcccatc ctccatcgag aaaaccatct ccaaagccaa agggcagccc      840

cgagagccac aggtgtacac cctgccccca tcccgggatg agctgaccaa gaaccaggtc      900

agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc      960

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1020

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc     1080

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg     1140

tctccgggta aaggtggtgg gtccggaggt acaattgaaa caacaggcaa tatatctgcc     1200

gagaagggtg gctcgatcat attacaatgc cacctctcat ccaccactgc acaagtaacc     1260

caggtcaatt gggaacagca ggatcagctg ctggccatct ataacgctga cttgggatgg     1320

cacatttccc catcgttcaa agatcgagtc gccccaggcc ccggcctcgg cctcacactc     1380

cagtctctga ccgtcaacga tacaggcgag tacttttgca tatatcacac ttaccctgac     1440

gggacctaca ctggtagaat cttcctagag gtcctagaga gctcagtcgc tgagcatggg     1500

gctagattcc agatccca                                                   1518


<210>  16
<211>  506
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1[G25-P141] Fc5 Barbell (otPA leader sequence)

<400>  16

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Leu Ser Gln Glu Ile His Ala Glu Leu Arg Arg 
            20                  25                  30          


Phe Arg Arg Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
        35                  40                  45              


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
    50                  55                  60                  


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
65                  70                  75                  80  


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
                85                  90                  95      


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
            100                 105                 110         


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
        115                 120                 125             


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
    130                 135                 140                 


His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys Ser Ser Asp Lys Thr 
145                 150                 155                 160 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser 
                165                 170                 175     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            180                 185                 190         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        195                 200                 205             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    210                 215                 220                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
225                 230                 235                 240 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                245                 250                 255     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr 
            260                 265                 270         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        275                 280                 285             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    290                 295                 300                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
305                 310                 315                 320 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                325                 330                 335     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            340                 345                 350         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        355                 360                 365             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala 
385                 390                 395                 400 


Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr 
                405                 410                 415     


Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala 
            420                 425                 430         


Ile Cys Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp 
        435                 440                 445             


Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr 
    450                 455                 460                 


Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp 
465                 470                 475                 480 


Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val 
                485                 490                 495     


Ala Glu His Gly Ala Arg Phe Gln Ile Pro 
            500                 505     


<210>  17
<211>  1479
<212>  DNA
<213>  Artificial

<220>
<223>  B7R1[G25-P141] C69Y Fc5 Barbell (EMIL leader sequence)

<400>  17
atgcggcgcc gcggatggag ctggatcttt ctctttcttc tgtcaggaac tgcaggtgtc       60

ctctctggca caatagaaac aacggggaac atttctgcag agaaaggtgg ctctatcatc      120

ttacaatgtc acctctcctc caccacggca caagtgaccc aggtcaactg ggagcagcag      180

gaccagcttc tggccattta taatgctgac ttggggtggc acatctcccc atcgttcaag      240

gatcgagtgg ccccaggtcc cggcctgggc ctcaccctcc agtcgctgac cgtgaacgat      300

acaggggagt acttctgcat ctatcacacc taccctgatg ggacgtacac tgggagaatc      360

ttcctggagg tcctagaaag ctcagtggct gagcacggtg ccaggttcca gattccagag      420

cccaaatctt cagacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgagggg      480

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccat cctccatcga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccgggat      840

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaaggtggtg ggtccggagg tacaattgaa     1140

acgacaggca atatatctgc cgagaagggt ggctcgatca tattacaatg ccacctctca     1200

tccaccactg cacaagtaac ccaggtcaat tgggaacagc aggatcagct gctggccatc     1260

tataacgctg acttgggatg gcacatttcc ccatcgttca aagatcgagt cgccccaggc     1320

cccggcctcg gcctcacact ccagtctctg accgtcaacg atacaggcga gtacttttgc     1380

atatatcaca cttaccctga cgggacctac actggtagaa tcttcctaga ggtcctagag     1440

agctcagtcg ctgagcatgg ggctagattc cagatccca                            1479


<210>  18
<211>  493
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1[G25-P141] C69Y Fc5 Barbell (EMIL leader sequence)

<400>  18

Met Arg Arg Arg Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly 
1               5                   10                  15      


Thr Ala Gly Val Leu Ser Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser 
            20                  25                  30          


Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr 
        35                  40                  45              


Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu 
    50                  55                  60                  


Ala Ile Tyr Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys 
65                  70                  75                  80  


Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu 
                85                  90                  95      


Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro 
            100                 105                 110         


Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser 
        115                 120                 125             


Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Glu Pro Lys Ser Ser 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
145                 150                 155                 160 


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys Gly Gly Gly Ser Gly Gly Thr Ile Glu Thr Thr Gly Asn 
    370                 375                 380                 


Ile Ser Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser 
385                 390                 395                 400 


Ser Thr Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln 
                405                 410                 415     


Leu Leu Ala Ile Tyr Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser 
            420                 425                 430         


Phe Lys Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln 
        435                 440                 445             


Ser Leu Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr 
    450                 455                 460                 


Tyr Pro Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu 
465                 470                 475                 480 


Ser Ser Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro 
                485                 490             


<210>  19
<211>  1524
<212>  DNA
<213>  Artificial

<220>
<223>  B7R1[G25-P141] C69Y Fc5 Tandem (EMIL leader sequence)

<400>  19
atgcggcgcc gcggatggag ctggatcttt ctctttcttc tgtcaggaac tgcaggtgtc       60

ctctctggca caatagaaac aacggggaac atttctgcag agaaaggtgg ctctatcatc      120

ttacaatgtc acctctcctc caccacggca caagtgaccc aggtcaactg ggagcagcag      180

gaccagcttc tggccattta taatgctgac ttggggtggc acatctcccc atcgttcaag      240

gatcgagtgg ccccaggtcc cggcctgggc ctcaccctcc agtcgctgac cgtgaacgat      300

acaggggagt acttctgcat ctatcacacc taccctgatg ggacgtacac tgggagaatc      360

ttcctggagg tcctagaaag ctcagtggct gagcacggtg ccaggttcca gattccaggt      420

ggtggtggtt ctggaggagg aggatcaggc gggggtggat ccggaggtgg tggttctggt      480

acaattgaaa cgacaggcaa tatatctgcc gagaagggtg gctcgatcat attacaatgc      540

cacctctcat ccaccactgc acaagtaacc caggtcaatt gggaacagca ggatcagctg      600

ctggccatct ataacgctga cttgggatgg cacatttccc catcgttcaa agatcgagtc      660

gccccaggcc ccggcctcgg cctcacactc cagtctctga ccgtcaacga tacaggcgag      720

tacttttgca tatatcacac ttaccctgac gggacctaca ctggtagaat cttcctagag      780

gtcctagaga gctcagtcgc tgagcatggg gctagattcc agatcccaga gcccaaatct      840

tcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgaggg ggcaccgtca      900

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      960

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     1020

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     1080

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac     1140

aagtgcaagg tctccaacaa agccctccca tcctccatcg agaaaaccat ctccaaagcc     1200

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccggga tgagctgacc     1260

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg     1320

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1380

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1440

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1500

agcctctccc tgtctccggg taaa                                            1524


<210>  20
<211>  508
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1[G25-P141] C69Y Fc5 Tandem (EMIL leader sequence)

<400>  20

Met Arg Arg Arg Gly Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly 
1               5                   10                  15      


Thr Ala Gly Val Leu Ser Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser 
            20                  25                  30          


Ala Glu Lys Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr 
        35                  40                  45              


Thr Ala Gln Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu 
    50                  55                  60                  


Ala Ile Tyr Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys 
65                  70                  75                  80  


Asp Arg Val Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu 
                85                  90                  95      


Thr Val Asn Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro 
            100                 105                 110         


Asp Gly Thr Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser 
        115                 120                 125             


Val Ala Glu His Gly Ala Arg Phe Gln Ile Pro Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
145                 150                 155                 160 


Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly Gly Ser Ile 
                165                 170                 175     


Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val Thr Gln Val 
            180                 185                 190         


Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Tyr Asn Ala Asp Leu 
        195                 200                 205             


Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala Pro Gly Pro 
    210                 215                 220                 


Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp Thr Gly Glu 
225                 230                 235                 240 


Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr Thr Gly Arg 
                245                 250                 255     


Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His Gly Ala Arg 
            260                 265                 270         


Phe Gln Ile Pro Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
    290                 295                 300                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
305                 310                 315                 320 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                325                 330                 335     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            340                 345                 350         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        355                 360                 365             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    370                 375                 380                 


Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
385                 390                 395                 400 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                405                 410                 415     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            420                 425                 430         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        435                 440                 445             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    450                 455                 460                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
465                 470                 475                 480 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                485                 490                 495     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505             


<210>  21
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  21
atggcccgag ccatggccgc cgcgtggccg ctgctgctgg tggcgctact ggtgctgtcc       60

tggccacccc caggaaccgg ggacgtcgtc gtgcaggcgc ccacccaggt gcccggcttc      120

ttgggcgact ccgtgacgct gccctgctac ctacaggtgc ccaacatgga ggtgacgcat      180

gtgtcacagc tgacttgggc gcggcatggt gaatctggca gcatggccgt cttccaccaa      240

acgcagggcc ccagctattc ggagtccaaa cggctggaat tcgtggcagc cagactgggc      300

gcggagctgc ggaatgcctc gctgaggatg ttcgggttgc gcgtagagga tgaaggcaac      360

tacacctgcc tgttcgtcac gttcccgcag ggcagcagga gcgtggatat ctggctccga      420

gtgcttgcca agccccagaa cacagctgag gttcagaagg tccagctcac tggagagcca      480

gtgcccatgg cccgctgcgt ctccacaggg ggtcgcccgc cagcccaaat cacctggcac      540

tcagacctgg gcgggatgcc caatacgagc caggtgccag ggttcctgtc tggcacagtc      600

actgtcacca gcctctggat attggtgccc tcaagccagg tggacggcaa gaatgtgacc      660

tgcaaggtgg agcacgagag ctttgagaag cctcagctgc tgactgtgaa cctcaccgtg      720

tactaccccc cagaggtatc catctctggc tatgataaca actggtacct tggccagaat      780

gaggccaccc tgacctgcga tgctcgcagc aacccagagc ccacaggcta taattggagc      840

acgaccatgg gtcccctgcc accctttgct gtggcccagg gcgcccagct cctgatccgt      900

cctgtggaca aaccaatcaa cacaacttta atctgcaacg tcaccaatgc cctaggagct      960

cgccaggcag aactgaccgt ccaggtcaaa gagggacctc ccagtgagca ctcaggcatg     1020

tcccgtaacg ccatcatctt cctggttctg ggaatcctgg tttttctgat cctgctgggg     1080

atcgggattt atttctattg gtccaaatgt tcccgtgagg tcctttggca ctgtcatctg     1140

tgtccctcga gtacagagca tgccagcgcc tcagctaatg ggcatgtctc ctattcagct     1200

gtgagcagag agaacagctc ttcccaggat ccacagacag agggcacaag gtga           1254


<210>  22
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Met Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  23
<211>  1227
<212>  DNA
<213>  Mus musculus

<400>  23
atggctcaac tcgcccgagc cacccgctcc ccgctgtcat ggctgctgct gctgttctgc       60

tatgcactcc ggaaagcggg tggggatata cgtgtgctgg tgccctacaa ttcgacaggc      120

gtcttgggag ggtcgaccac cttgcactgt agtctgactt ctaatgagaa tgtgactatc      180

actcaaataa cctggatgaa gaaggattca ggtggatccc acgctcttgt ggctgtcttc      240

caccccaaga aggggcccaa catcaaagag ccagagaggg tgaaattctt ggctgcccaa      300

caggatctga ggaacgcatc tctggccatc tcgaacttaa gtgtagaaga cgaaggcatc      360

tatgaatgtc agattgccac attccccaga ggcagtagaa gcaccaatgc ctggctgaag      420

gtgcaagccc gacctaagaa cactgcagag gccctggagc cctctcccac cttgatactg      480

caggatgtgg ctaaatgcat ctctgccaat ggtcaccctc ctggacgaat ctcttggccc      540

tcgaatgtga atggaagtca ccgtgaaatg aaggaaccag ggtcccagcc gggcaccacc      600

acagttacca gctacctctc catggtacct tctcgccagg cagacggcaa gaacatcacc      660

tgcacggtgg agcatgaaag cttacaggag ctggaccagc tgctggtgac cctttcccaa      720

ccctatccac ctgaaaacgt gtccatctct ggctatgacg gcaactggta tgttggcctc      780

actaacttga ccctgacctg tgaagctcac agcaaaccag cgcctgacat ggctggatat      840

aactggagca cgaacacggg tgactttccc aactctgtta agcgccaggg caatatgctt      900

ctaatctcca ccgtagagga tggtctcaat aacacggtca ttgtgtgcga agtcaccaat      960

gccctagggt ctgggcaggg ccaagtgcac atcattgtta aagagaaacc tgagaatatg     1020

cagcaaaata caagattaca cctaggctac atctttctta tcgtctttgt cctcgctgta     1080

gtcatcatca tcgcagcact atacactata cgaagatgca ggcatggtcg tgctctgcag     1140

tccaatccct cagagaggga gaacgtccag tattcatctg tgaacggcga ctgtagactg     1200

aacatggagc caaacagcac aaggtga                                         1227


<210>  24
<211>  408
<212>  PRT
<213>  Mus musculus

<400>  24

Met Ala Gln Leu Ala Arg Ala Thr Arg Ser Pro Leu Ser Trp Leu Leu 
1               5                   10                  15      


Leu Leu Phe Cys Tyr Ala Leu Arg Lys Ala Gly Gly Asp Ile Arg Val 
            20                  25                  30          


Leu Val Pro Tyr Asn Ser Thr Gly Val Leu Gly Gly Ser Thr Thr Leu 
        35                  40                  45              


His Cys Ser Leu Thr Ser Asn Glu Asn Val Thr Ile Thr Gln Ile Thr 
    50                  55                  60                  


Trp Met Lys Lys Asp Ser Gly Gly Ser His Ala Leu Val Ala Val Phe 
65                  70                  75                  80  


His Pro Lys Lys Gly Pro Asn Ile Lys Glu Pro Glu Arg Val Lys Phe 
                85                  90                  95      


Leu Ala Ala Gln Gln Asp Leu Arg Asn Ala Ser Leu Ala Ile Ser Asn 
            100                 105                 110         


Leu Ser Val Glu Asp Glu Gly Ile Tyr Glu Cys Gln Ile Ala Thr Phe 
        115                 120                 125             


Pro Arg Gly Ser Arg Ser Thr Asn Ala Trp Leu Lys Val Gln Ala Arg 
    130                 135                 140                 


Pro Lys Asn Thr Ala Glu Ala Leu Glu Pro Ser Pro Thr Leu Ile Leu 
145                 150                 155                 160 


Gln Asp Val Ala Lys Cys Ile Ser Ala Asn Gly His Pro Pro Gly Arg 
                165                 170                 175     


Ile Ser Trp Pro Ser Asn Val Asn Gly Ser His Arg Glu Met Lys Glu 
            180                 185                 190         


Pro Gly Ser Gln Pro Gly Thr Thr Thr Val Thr Ser Tyr Leu Ser Met 
        195                 200                 205             


Val Pro Ser Arg Gln Ala Asp Gly Lys Asn Ile Thr Cys Thr Val Glu 
    210                 215                 220                 


His Glu Ser Leu Gln Glu Leu Asp Gln Leu Leu Val Thr Leu Ser Gln 
225                 230                 235                 240 


Pro Tyr Pro Pro Glu Asn Val Ser Ile Ser Gly Tyr Asp Gly Asn Trp 
                245                 250                 255     


Tyr Val Gly Leu Thr Asn Leu Thr Leu Thr Cys Glu Ala His Ser Lys 
            260                 265                 270         


Pro Ala Pro Asp Met Ala Gly Tyr Asn Trp Ser Thr Asn Thr Gly Asp 
        275                 280                 285             


Phe Pro Asn Ser Val Lys Arg Gln Gly Asn Met Leu Leu Ile Ser Thr 
    290                 295                 300                 


Val Glu Asp Gly Leu Asn Asn Thr Val Ile Val Cys Glu Val Thr Asn 
305                 310                 315                 320 


Ala Leu Gly Ser Gly Gln Gly Gln Val His Ile Ile Val Lys Glu Lys 
                325                 330                 335     


Pro Glu Asn Met Gln Gln Asn Thr Arg Leu His Leu Gly Tyr Ile Phe 
            340                 345                 350         


Leu Ile Val Phe Val Leu Ala Val Val Ile Ile Ile Ala Ala Leu Tyr 
        355                 360                 365             


Thr Ile Arg Arg Cys Arg His Gly Arg Ala Leu Gln Ser Asn Pro Ser 
    370                 375                 380                 


Glu Arg Glu Asn Val Gln Tyr Ser Ser Val Asn Gly Asp Cys Arg Leu 
385                 390                 395                 400 


Asn Met Glu Pro Asn Ser Thr Arg 
                405             


<210>  25
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide linker

<400>  25

Gly Gly Gly Ser Gly 
1               5   


<210>  26
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Polypeptide linker


<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  Xaa is either Gly or is absent

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa is either Ser of is absent

<220>
<221>  misc_feature
<222>  (21)..(24)
<223>  Xaa is either Gly or is absent

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa is either Ser or is absent

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25  


<210>  27
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  28
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  28

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  29
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Fc-488

<400>  29

Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  30
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Fc4

<400>  30

Glu Pro Arg Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  31
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Fc5

<400>  31

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  32
<211>  231
<212>  PRT
<213>  Artificial

<220>
<223>  Fc6

<400>  32

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  33
<211>  232
<212>  PRT
<213>  Artificial

<220>
<223>  Fc7

<400>  33

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Glu Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  34
<211>  346
<212>  PRT
<213>  Artificial

<220>
<223>  mB7R1-mFc2

<400>  34

Gly Thr Ile Asp Thr Lys Arg Asn Ile Ser Ala Glu Glu Gly Gly Ser 
1               5                   10                  15      


Val Ile Leu Gln Cys His Phe Ser Ser Asp Thr Ala Glu Val Thr Gln 
            20                  25                  30          


Val Asp Trp Lys Gln Gln Asp Gln Leu Leu Ala Ile Tyr Ser Val Asp 
        35                  40                  45              


Leu Gly Trp His Val Ala Ser Val Phe Ser Asp Arg Val Val Pro Gly 
    50                  55                  60                  


Pro Ser Leu Gly Leu Thr Phe Gln Ser Leu Thr Met Asn Asp Thr Gly 
65                  70                  75                  80  


Glu Tyr Phe Cys Thr Tyr His Thr Tyr Pro Gly Gly Ile Tyr Lys Gly 
                85                  90                  95      


Arg Ile Phe Leu Lys Val Gln Glu Ser Ser Val Ala Gln Phe Gln Thr 
            100                 105                 110         


Ala Glu Pro Arg Ser Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
        115                 120                 125             


Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
145                 150                 155                 160 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
                165                 170                 175     


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
            180                 185                 190         


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
        195                 200                 205             


His Gln Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala Val Asn Asn 
    210                 215                 220                 


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
225                 230                 235                 240 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
                245                 250                 255     


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
            260                 265                 270         


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
        275                 280                 285             


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
    290                 295                 300                 


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
305                 310                 315                 320 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
                325                 330                 335     


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345     


<210>  35
<211>  168
<212>  PRT
<213>  Artificial

<220>
<223>  mB7R1-VASP

<400>  35

Gly Thr Ile Asp Thr Lys Arg Asn Ile Ser Ala Glu Glu Gly Gly Ser 
1               5                   10                  15      


Val Ile Leu Gln Cys His Phe Ser Ser Asp Thr Ala Glu Val Thr Gln 
            20                  25                  30          


Val Asp Trp Lys Gln Gln Asp Gln Leu Leu Ala Ile Tyr Ser Val Asp 
        35                  40                  45              


Leu Gly Trp His Val Ala Ser Val Phe Ser Asp Arg Val Val Pro Gly 
    50                  55                  60                  


Pro Ser Leu Gly Leu Thr Phe Gln Ser Leu Thr Met Asn Asp Thr Gly 
65                  70                  75                  80  


Glu Tyr Phe Cys Thr Tyr His Thr Tyr Pro Gly Gly Ile Tyr Lys Gly 
                85                  90                  95      


Arg Ile Phe Leu Lys Val Gln Glu Ser Ser Val Ala Gln Phe Gln Thr 
            100                 105                 110         


Ala Glu Pro Arg Ser Gly Ser Gly Gly Ser Gly Gly Ser Asp Leu Gln 
        115                 120                 125             


Arg Val Lys Gln Glu Leu Leu Glu Glu Val Lys Lys Glu Leu Gln Lys 
    130                 135                 140                 


Val Lys Glu Glu Ile Ile Glu Ala Phe Val Gln Glu Leu Arg Gly Ser 
145                 150                 155                 160 


Gly Gly His His His His His His 
                165             


<210>  36
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60639)

<400>  36
caggtgtcca gggaattcat ataggccggc caccatgcat ggctggctgc tcctg            55


<210>  37
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60643)

<400>  37
cggccgcatt cctgaggttt ttatccggac ccaccacctt tacccggagt ccgggagaag       60

c                                                                       61


<210>  38
<211>  59
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60645)

<400>  38
caaccccaga gctgttttaa ggcgcgcctc tagaaacggc cgcattcctg aggttttta        59


<210>  39
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60642)

<400>  39
gtggtgggtc cggaggcacg atagatacaa agag                                   34


<210>  40
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60641)

<400>  40
gcgcctctag aaacggccgc attcctgagg tttttaggca gtctggaac                   49


<210>  41
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc53051)

<400>  41
caggtgtcca gggaattcat ataggccggc caccatgcgc tggtgtctcc tcctgatctg       60

ggcc                                                                    64


<210>  42
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60385)

<400>  42
gagttttgtc tgaagatttg ggctctggaa tctggaacct ggcaccg                     47


<210>  43
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60386

<400>  43
caggttccag attccagagc ccaaatcttc agacaaaact cacac                       45


<210>  44
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc59433)

<400>  44
aaagatctca ttcctgaggt ttttatccgg acccaccacc tttacccgga gacagggaga       60

g                                                                       61


<210>  45
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc59434)

<400>  45
caaccccaga gctgttttaa ggcgcgcctc tagattaaaa gatctcattc ctgaggtttt       60

ta                                                                      62


<210>  46
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60640)

<400>  46
gatcctgagc ccgaaccgcc ggcagtctgg aactgagcca c                           41


<210>  47
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60644)

<400>  47
gcctccggac ccaccaccag aaccaccgga acctgaacct cccgatcctg agcccgaacc       60

gcc                                                                     63


<210>  48
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60642)

<400>  48
gtggtgggtc cggaggcacg atagatacaa agag                                   34


<210>  49
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc28844)

<400>  49
gacggatggt ccaccctcga ggttaggtgc tgg                                    33


<210>  50
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc62529)

<400>  50
cgatcctgag cccgaaccgc ctggaatctg gaacctggca ccgtg                       45


<210>  51
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc62530)

<400>  51
accagatccg gacccaccac cagaaccacc ggaacctgaa cctcccgatc ctgagcccga       60

accgcc                                                                  66


<210>  52
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc62531)

<400>  52
ctggtggtgg gtccggaatg atgacaggca caatagaaac aac                         43


<210>  53
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc62532)

<400>  53
accagaaaga tctcattcct gaggttttta tttacccgga gacagggaga ggct             54


<210>  54
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64230)

<400>  54
caggaaatcc atgccgagtt gagacgcttc cgtagaggca caatagaaac aacggggaac       60


<210>  55
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64219)

<400>  55
cttgaaggat ggggagatgt gccaccccaa gtcagcatta caaatggcca gaagctggtc       60

ctgctg                                                                  66


<210>  56
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64215)

<400>  56
aatgctgact tggggtggca catctcccca tccttcaagg atcgagtggc cccaggtccc       60


<210>  57
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64216)

<400>  57
tccggaccca ccacctttac ccggagacag ggagaggctc ttctgcgtgt agtggttgtg       60


<210>  58
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64228)

<400>  58
aagagcctct ccctgtctcc gggtaaaggt ggtgggtccg gaggtacaat tgaaacgaca       60

ggcaat                                                                  66


<210>  59
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64220)

<400>  59
gtggcattgt aatatgatcg agccaccctt ctcggcagat atattgcctg tcgtttcaat       60

tgt                                                                     63


<210>  60
<211>  73
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64224)

<400>  60
gatcatatta caatgccacc tctcatccac cactgcacaa gtaacccagg tcaattggga       60

acagcaggat cag                                                          73


<210>  61
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64231)

<400>  61
cgatggggaa atgtgccatc ccaagtcagc gttacagatg gccagcagct gatcctgctg       60

ttccca                                                                  66


<210>  62
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64225)

<400>  62
tggcacattt ccccatcgtt caaagatcga gtcgccccag gccccggcct cggcctcaca       60

ctc                                                                     63


<210>  63
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64221)

<400>  63
gtgatatatg caaaagtact cgcctgtatc gttgacggtc agagactgga gtgtgaggcc       60

gaggcc                                                                  66


<210>  64
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64226)

<400>  64
gtacttttgc atatatcaca cttaccctga cgggacctac actggtagaa tcttcctaga       60

ggtcctag                                                                68


<210>  65
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64222)

<400>  65
ttatgggatc tggaatctag ccccatgctc agcgactgag ctctctagga cctctaggaa       60

gattc                                                                   65


<210>  66
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64223)

<400>  66
taaggcgcgc ctctagatta aaagatctca ttcctgaggt ttttatggga tctggaatct       60

agccccatg                                                               69


<210>  67
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64258)

<400>  67
catggggcta gattccagat cccataaaaa cctcaggaat gagatctttt aatctagagg       60

cgcgcctta                                                               69


<210>  68
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64218)

<400>  68
cttgaaggat ggggagatgt gccaccccaa gtcagcatta taaatggcca gaagctggtc       60

ctgctg                                                                  66


<210>  69
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc64227)

<400>  69
cgatggggaa atgtgccatc ccaagtcagc gttatagatg gccagcagct gatcctgctg       60

ttccca                                                                  66


<210>  70
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65030)

<400>  70
tctccacagg tgtccaggga attcatatag gccggccacc atgcggcgcc gcggatggag       60

ctggatcttt ctctttcttc tg                                                82


<210>  71
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65029)

<400>  71
agctggatct ttctctttct tctgtcagga actgcaggtg tcctctctgg cacaatagaa       60

acaacgggga ac                                                           72


<210>  72
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65050)

<400>  72
agaaccacca cctccggatc cacccccgcc tgatcctcct cctccagaac caccaccacc       60

tggaatctgg aacctggcac cg                                                82


<210>  73
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65051)

<400>  73
ggaggaggag gatcaggcgg gggtggatcc ggaggtggtg gttctggtac aattgaaacg       60

acaggcaat                                                               69


<210>  74
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65052)

<400>  74
cggtgggcat gtgtgagttt tgtctgaaga tttgggctct gggatctgga atctagcccc       60

a                                                                       61


<210>  75
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65053)

<400>  75
gagcccaaat cttcagacaa aactcacaca tgcccaccgt gcccagcacc tgaagcc          57


<210>  76
<211>  85
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc65054)

<400>  76
caaccccaga gctgttttaa ggcgcgcctc tagattaaaa gatctcattc ctgaggtttt       60

tatttacccg gagacaggga gaggc                                             85


<210>  77
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc59435)

<400>  77
ggtaaaggtg gtgggtccgg aatgatgaca ggcacaatag aaac                        44


<210>  78
<211>  55
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer (zc60392)

<400>  78
ctagattaaa agatctcatt cctgaggttt ttatggaatc tggaacctgg caccg            55


<210>  79
<211>  352
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1-Fc2

<400>  79

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Ala 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Glu Pro Arg Ser Pro Thr Ile Lys Pro 
        115                 120                 125             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
145                 150                 155                 160 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                165                 170                 175     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            180                 185                 190         


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
        195                 200                 205             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Ala Phe 
    210                 215                 220                 


Ala Cys Ala Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
225                 230                 235                 240 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                245                 250                 255     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            260                 265                 270         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        275                 280                 285             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
305                 310                 315                 320 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                325                 330                 335     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345                 350         


<210>  80
<211>  349
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1[G25-P141] C69Y Fc5

<400>  80

Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys Gly Gly Ser 
1               5                   10                  15      


Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln Val Thr Gln 
            20                  25                  30          


Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Tyr Asn Ala Asp 
        35                  40                  45              


Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val Ala Pro Gly 
    50                  55                  60                  


Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn Asp Thr Gly 
65                  70                  75                  80  


Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr Tyr Thr Gly 
                85                  90                  95      


Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu His Gly Ala 
            100                 105                 110         


Arg Phe Gln Ile Pro Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
        115                 120                 125             


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
    130                 135                 140                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
145                 150                 155                 160 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                165                 170                 175     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            180                 185                 190         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        195                 200                 205             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    210                 215                 220                 


Val Ser Asn Lys Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
225                 230                 235                 240 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                245                 250                 255     


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            260                 265                 270         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        275                 280                 285             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    290                 295                 300                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
305                 310                 315                 320 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                325                 330                 335     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 


<210>  81
<211>  173
<212>  PRT
<213>  Artificial

<220>
<223>  B7R1-VASP

<400>  81

Met Met Thr Gly Thr Ile Glu Thr Thr Gly Asn Ile Ser Ala Glu Lys 
1               5                   10                  15      


Gly Gly Ser Ile Ile Leu Gln Cys His Leu Ser Ser Thr Thr Ala Gln 
            20                  25                  30          


Val Thr Gln Val Asn Trp Glu Gln Gln Asp Gln Leu Leu Ala Ile Cys 
        35                  40                  45              


Asn Ala Asp Leu Gly Trp His Ile Ser Pro Ser Phe Lys Asp Arg Val 
    50                  55                  60                  


Ala Pro Gly Pro Gly Leu Gly Leu Thr Leu Gln Ser Leu Thr Val Asn 
65                  70                  75                  80  


Asp Thr Gly Glu Tyr Phe Cys Ile Tyr His Thr Tyr Pro Asp Gly Thr 
                85                  90                  95      


Tyr Thr Gly Arg Ile Phe Leu Glu Val Leu Glu Ser Ser Val Ala Glu 
            100                 105                 110         


His Gly Ala Arg Phe Gln Ile Pro Arg Ser Gly Ser Gly Gly Ser Gly 
        115                 120                 125             


Gly Ser Asp Leu Gln Arg Val Lys Gln Glu Leu Leu Glu Glu Val Lys 
    130                 135                 140                 


Lys Glu Leu Gln Lys Val Lys Glu Glu Ile Ile Glu Ala Phe Val Gln 
145                 150                 155                 160 


Glu Leu Arg Gly Ser Gly Gly His His His His His His 
                165                 170             


