                         SEQUENCE LISTING

<110>  The University of Texas System
 
<120>  Methods of Treating Pain and Morphine Tolerance via Modulation of the Hedgehog Signaling Pathway

<130>  MDA10-050 (NIPL 07P49PR)

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  3111
<212>  DNA
<213>  Drosophila melanogaster

<400>  1
atgcagtact taaactttcc gcgcatgcca aacattatga tgttcctgga ggttgcgatc       60

ttatgcctgt gggtggtcgc agacgcatcg gccagttcgg ccaagttcgg cagcacaacg      120

cccgcaagtg cgcagcagtc ggatgtggaa ctggagccca tcaatgggac tctcaattac      180

cgactgtacg ccaagaaggg cagggacgac aaaccctggt ttgatggcct agacagcagg      240

cacatccagt gtgtccgacg tgcccgttgc taccccacct cgaacgcaac caacacctgt      300

ttcggctcaa aattgcccta tgagctgagc agcctagatc tcaccgactt ccacaccgaa      360

aaggagctga acgataagct gaacgactac tatgccctga agcacgtgcc caaatgttgg      420

gcagctatac agcccttttt gtgcgccgtc tttaagccga agtgtgaaaa aatcaacggc      480

gaggacatgg tctacctgcc atcttacgag atgtgccgaa ttaccatgga accctgtcgc      540

attttgtaca acacgacgtt tttcccaaaa ttccttcgct gcaacgaaac actctttccg      600

acgaaatgca caaacggagc acgaggaatg aaattcaacg gaactggcca gtgtttaagt      660

cctttggttc cgacagatac gtcagccagc tattatcctg gcatcgaggg ctgcggcgtg      720

cgatgcaagg atccactcta taccgatgat gagcatcggc agatccacaa actgatcgga      780

tgggctggca gcatatgtct tctgtctaac cttttcgtgg tgtccacctt cttcatcgac      840

tggaagaatg ccaacaagta tccggcagta attgtgttct acataaatct ttgctttcta      900

attgcttgcg tcggctggtt gcttcagttt acttctggct cgcgagagga catagtatgt      960

cgtaaggatg gaacacttcg ccactcagag cctacagccg gtgaaaatct ttcttgcata     1020

gtgatctttg tgctggtcta ttattttctc accgctggaa tggtttggtt tgtgttcctc     1080

acctacgcct ggcattggag ggccatgggc cacgtccaag atcggataga taagaaaggt     1140

tcctactttc acctcgtggc gtggtcacta ccccttgtgc ttaccattac cacgatggct     1200

ttcagtgagg tggatggaaa tagtattgtg ggcatctgct tcgtaggcta tatcaatcat     1260

tctatgaggg caggactact tcttggtccg ctctgcgggg tcatcctcat tggtggatac     1320

ttcatcaccc gcggcatggt gatgcttttt ggactgaaac acttcgctaa tgacattaaa     1380

tcaacttcgg cgagcaacaa aatccatttg atcatcatgc gcatgggagt ctgtgctctg     1440

ctcactttag ttttcatact agtggccatt gcgtgccacg ttacggagtt taggcatgca     1500

gacgaatggg cccagagctt cagacagttt ataatctgca aaatttcttc agtttttgaa     1560

gaaaagagtt cctgtcgaat tgaaaaccga cctagtgttg gcgttcttca attgcatttg     1620

ctgtgtctat ttagctctgg aatcgtaatg tccacctggt gctggacacc ttcttcaatt     1680

gagacttgga agcgttatat aaggaaaaag tgtggcaaag aggtggtcga agaagtgaaa     1740

atgccgaagc acaaggtcat tgcccagaca tgggccaagc gcaaggattt cgaggacaag     1800

ggcaggctct ccataacgct ctacaacacc cacacagatc ccgtggggct caacttcgat     1860

gtgaacgatc tgaactcttc tgagacgaat gacatctcat caacttgggc tgcatacctc     1920

ccgcagtgcg taaaacgtcg catggctttg acgggagcag cgacaggtaa ctcgtcaagc     1980

catggaccgc gaaaaaattc attggattcc gagataagtg tgagtgttcg acatgtttcc     2040

gttgaatccc gcagaaattc ggtggactcg caggtatcag tgaaaatagc tgaaatgaag     2100

accaaagtgg cgtccagatc aaggggaaaa cacggaggct cttccagcaa cagaagaacc     2160

caaaggagaa gggattatat agcagctgcc actggaaaaa gcagtaggag aagggaaagc     2220

agtacttcag tggagtcgca ggtcatcgcg ctcaagaaaa cgacctatcc caatgctagt     2280

cacaaagtgg gcgtgtttgc tcatcacagc tccaagaaac aacacaatta caccagctcc     2340

atgaagcgaa ggactgctaa tgccggattg gatccctcta ttcttaatga attcctgcag     2400

aaaaatggcg attttatatt cccattcctc caaaatcaag atatgagctc tagttcggag     2460

gaggataatt ccagagcatc ccaaaagatt caggatctta acgtggttgt aaagcagcag     2520

gaaataagtg aggatgatca cgacggaata aagattgaag aactgccaaa tagcaaacag     2580

gtggcattgg agaactttct taaaaacata aaaaaatcta atgaatccaa ttctaaccga     2640

cattcccgaa attccgcaag aagtcagtca aaaaagtccc aaaagagaca tctcaagaac     2700

cctgctgctg atctagattt caggaaggac tgtgtaaagt atcggtctaa tgactcactt     2760

agctgctcct ctgaagagct ggatgtggct ttggacgtag gaagccttct taacagctct     2820

ttttctggaa tatccatggg caaaccacat agtagaaaca gcaaaaccag ctgcgatgtg     2880

ggcatacagg ctaatccttt cgagctagtt cccagttacg gagaagacga actgcagcag     2940

gccatgcgac tcctaaacgc agccagcaga caaagaactg aagcagccaa tgaggatttc     3000

ggaggaacgg agctgcaggg cttgttgggt cattcccatc ggcatcaaag ggagcccacg     3060

tttatgagcg agtcggacaa actcaaaatg ttattgctgc cttcaaaata g              3111


<210>  2
<211>  3861
<212>  DNA
<213>  Drosophila melanogaster

<400>  2
atggaccgcg acagcctccc acgcgttccg gacacacacg gcgatgtggt cgatgagaaa       60

ttattctcgg atctttacat acgcaccagc tgggtggacg cccaagtggc gctcgatcag      120

atagataagg gcaaagcgcg tggcagccgc acggcgatct atctgcgatc agtattccag      180

tcccacctcg aaaccctcgg cagctccgtg caaaagcacg cgggcaaggt gctattcgtg      240

gctatcctgg tgctgagcac cttctgcgtc ggcctgaaga gcgcccagat ccactccaag      300

gtgcaccagc tgtggatcca ggagggcggc cggctggagg cggaactggc ctacacacag      360

aagacgatcg gcgaggacga gtcggccacg catcagctgc tcattcagac gacccacgac      420

ccgaacgcct ccgtcctgca tccgcaggcg ctgcttgccc acctggaggt cctggtcaag      480

gccaccgccg tcaaggtgca cctctacgac accgaatggg ggctgcgcga catgtgcaac      540

atgccgagca cgccctcctt cgagggcatc tactacatcg agcagatcct gcgccacctc      600

attccgtgct cgatcatcac gccgctggac tgtttctggg agggaagcca gctgttgggt      660

ccggaatcag cggtcgttat accaggcctc aaccaacgac tcctgtggac cacactgaat      720

cccgcctctg tgatgcagta tatgaagcag aagatgtccg aggaaaagat cagcttcgac      780

ttcgagaccg tggagcagta catgaagcgt gcggccattg gcagtggcta catggagaag      840

ccctgcctga acccactgaa tcccaattgc ccggacacgg caccgaacaa gaacagcacc      900

cagccgccgg atgtgggagc catcctgtcc ggaggctgct acggttatgc cgcgaagcat      960

atgcactggc cggaggaact gattgtgggc ggagcgaaga ggaaccgcag cggacacttg     1020

aggaaggccc aggccctgca gtcggtggtg cagctgatga ccgagaagga aatgtacgac     1080

cagtggcagg acaactacaa ggtgcaccat cttggatgga cgcaggagaa ggcagcggag     1140

gttttgaacg cctggcagcg caacttttcg cgggaggtgg aacagctgct acgtaaacag     1200

tcgagaattg ccaccaacta cgatatctac gtgttcagct cggctgcact ggatgacatc     1260

ctggccaagt tctcccatcc cagcgccttg tccattgtca tcggcgtggc cgtcaccgtt     1320

ttgtatgcct tctgcacgct cctccgctgg agggaccccg tccgtggaca gagcagtgtc     1380

ggcgtggccg gagttctgct catgtgcttt agtaccgccg ccggattggg attgtcagcc     1440

ctgctcggta tcgttttcaa tgccgccagc acccaggtgg ttccgttttt ggcccttggt     1500

ctgggcgtcg atcacatctt catgctgacc gctgcctatg cggagagcaa tcggcgggag     1560

cagaccaagc tgattctcaa gaaagtggga ccgagcatcc tgttcagtgc ctgcagcacg     1620

gcaggatcct tctttgcggc cgcctttatt ccggtgccgg ctttgaaggt attctgtctg     1680

caggctgcca tcgtaatgtg ctccaatttg gcagcggctc tattggtttt tccggccatg     1740

atttcgttgg atctacggag acgtaccgcc ggcagggcgg acatcttctg ctgctgtttt     1800

ccggtgtgga aggaacagcc gaaggtggca ccaccggtgc tgccgctgaa caacaacaac     1860

gggcgcgggg cccggcatcc gaagagctgc aacaacaaca gggtgccgct gcccgcccag     1920

aatcctctgc tggaacagag ggcagacatc cctgggagca gtcactcact ggcgtccttc     1980

tctctggcaa ccttcgcctt tcagcactac actcccttcc tcatgcgcag ctgggtgaag     2040

ttcctgaccg ttatgggttt cctggcggcc ctcatatcca gcttgtatgc ctccacgcgc     2100

cttcaggatg gcctggacat tattgatctg gtgcccaagg acagcaacga gcacaagttc     2160

ctggatgctc aaactcggct ctttggcttc tacagcatgt atgcggttac ccagggcaac     2220

tttgaatatc ccacccagca gcagttgctc agggactacc atgattcctt tgtgcgggtg     2280

ccacatgtga tcaagaatga taatggtgga ctgccggact tctggctgct gctcttcagc     2340

gagtggctgg gtaatctgca aaagatattc gacgaggaat accgcgacgg acggctgacc     2400

aaggagtgct ggttcccaaa cgccagcagc gatgccatcc tggcctacaa gctaatcgtg     2460

caaaccggcc atgtggacaa ccccgtggac aaggaactgg tgctcaccaa tcgcctggtc     2520

aacagcgatg gcatcatcaa ccaacgcgcc ttctacaact atctgtcggc atgggccacc     2580

aacgacgtct tcgcctacgg agcttctcag ggcaaattgt atccggaacc gcgccagtat     2640

tttcaccaac ccaacgagta cgatcttaag atacccaaga gtctgccatt ggtctacgct     2700

cagatgccct tttacctcca cggactaaca gatacctcgc agatcaagac cctgataggt     2760

catattcgcg acctgagcgt caagtacgag ggcttcggcc tgcccaacta tccatcgggc     2820

attcccttca tcttctggga gcagtacatg accctgcgct cctcactggc catgatcctg     2880

gcctgcgtgc tactcgccgc cctggtgctg gtctccctgc tcctgctctc cgtttgggcc     2940

gccgttctcg tgatcctcag cgttctggcc tcgctggccc agatctttgg ggccatgact     3000

ctgctgggca tcaaactctc ggccattccg gcagtcatac tcatcctcag cgtgggcatg     3060

atgctgtgct tcaatgtgct gatatcactg ggcttcatga catccgttgg caaccgacag     3120

cgccgcgtcc agctgagcat gcagatgtcc ctgggaccac ttgtccacgg catgctgacc     3180

tccggagtgg ccgtgttcat gctctccacg tcgccctttg agtttgtgat ccggcacttc     3240

tgctggcttc tgctggtggt cttatgcgtt ggcgcctgca acagcctttt ggtgttcccc     3300

atcctactga gcatggtggg accggaggcg gagctggtgc cgctggagca tccagaccgc     3360

atatccacgc cctctccgct gcccgtgcgc agcagcaaga gatcgggcaa atcctatgtg     3420

gtgcagggat cgcgatcctc gcgaggcagc tgccagaagt cgcatcacca ccaccacaaa     3480

gaccttaatg atccatcgct gacgacgatc accgaggagc cgcagtcgtg gaagtccagc     3540

aactcgtcca tccagatgcc caatgattgg acctaccagc cgcgggaaca gcgacccgcc     3600

tcctacgcgg ccccgccccc cgcctatcac aaggccgccg cccagcagca ccaccagcat     3660

cagggcccgc ccacaacgcc cccgcctccc ttcccgacgg cctatccgcc ggagctgcag     3720

agcatcgtgg tgcagccgga ggtgacggtg gagacgacgc actcggacag caacaccacc     3780

aaggtgacgg ccacggccaa catcaaggtg gagctggcca tgcccggcag ggcggtgcgc     3840

agctataact ttacgagtta g                                               3861


