                         SEQUENCE LISTING

<110>  The UAB Research Foundation
       Chugh, Sumant  S.
 
<120>  METHODS FOR TREATMENT OF NEPHROTIC SYNDROME AND RELATED 
       CONDITIONS

<130>  U2010-0044WO

<150>  61/351,866
<151>  2010-06-05

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  2
<211>  1967
<212>  DNA
<213>  Homo sapiens

<400>  2
ataaaaaccg tcctcgggcg cggcggggag aagccgagct gagcggatcc tcacacgact       60

gtgatccgat tctttccagc ggcttctgca accaagcggg tcttaccccc ggtcctccgc      120

gtctccagtc ctcgcacctg gaaccccaac gtccccgaga gtccccgaat ccccgctccc      180

aggctaccta agaggatgag cggtgctccg acggccgggg cagccctgat gctctgcgcc      240

gccaccgccg tgctactgag cgctcagggc ggacccgtgc agtccaagtc gccgcgcttt      300

gcgtcctggg acgagatgaa tgtcctggcg cacggactcc tgcagctcgg ccaggggctg      360

cgcgaacacg cggagcgcac ccgcagtcag ctgagcgcgc tggagcggcg cctgagcgcg      420

tgcgggtccg cctgtcaggg aaccgagggg tccaccgacc tcccgttagc ccctgagagc      480

cgggtggacc ctgaggtcct tcacagcctg cagacacaac tcaaggctca gaacagcagg      540

atccagcaac tcttccacaa ggtggcccag cagcagcggc acctggagaa gcagcacctg      600

cgaattcagc atctgcaaag ccagtttggc ctcctggacc acaagcacct agaccatgag      660

gtggccaagc ctgcccgaag aaagaggctg cccgagatgg cccagccagt tgacccggct      720

cacaatgtca gccgcctgca ccggctgccc agggattgcc aggagctgtt ccaggttggg      780

gagaggcaga gtggactatt tgaaatccag cctcaggggt ctccgccatt tttggtgaac      840

tgcaagatga cctcagatgg aggctggaca gtaattcaga ggcgccacga tggctcagtg      900

gacttcaacc ggccctggga agcctacaag gcggggtttg gggatcccca cggcgagttc      960

tggctgggtc tggagaaggt gcatagcatc acgggggacc gcaacagccg cctggccgtg     1020

cagctgcggg actgggatgg caacgccgag ttgctgcagt tctccgtgca cctgggtggc     1080

gaggacacgg cctatagcct gcagctcact gcacccgtgg ccggccagct gggcgccacc     1140

accgtcccac ccagcggcct ctccgtaccc ttctccactt gggaccagga tcacgacctc     1200

cgcagggaca agaactgcgc caagagcctc tctggaggct ggtggtttgg cacctgcagc     1260

cattccaacc tcaacggcca gtacttccgc tccatcccac agcagcggca gaagcttaag     1320

aagggaatct tctggaagac ctggcggggc cgctactacc cgctgcaggc caccaccatg     1380

ttgatccagc ccatggcagc agaggcagcc tcctagcgtc ctggctgggc ctggtcccag     1440

gcccacgaaa gacggtgact cttggctctg cccgaggatg tggccgttcc ctgcctgggc     1500

aggggctcca aggaggggcc atctggaaac ttgtggacag agaagaagac cacgactgga     1560

gaagccccct ttctgagtgc aggggggctg catgcgttgc ctcctgagat cgaggctgca     1620

ggatatgctc agactctaga ggcgtggacc aaggggcatg gagcttcact ccttgctggc     1680

cagggagttg gggactcaga gggaccactt ggggccagcc agactggcct caatggcgga     1740

ctcagtcaca ttgactgacg gggaccaggg cttgtgtggg tcgagagcgc cctcatggtg     1800

ctggtgctgt tgtgtgtagg tcccctgggg acacaagcag gcgccaatgg tatctgggcg     1860

gagctcacag agttcttgga ataaaagcaa cctcagaaca cttaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                   1967


<210>  3
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser Ala Cys 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His His Gly Gly Trp Thr Val Ile Gln Arg Arg 
            180                 185                 190         


His Asp Gly Ser Val Asp Phe Asn Arg Pro Trp Glu Ala Tyr Lys Ala 
        195                 200                 205             


Gly Phe Gly Asp Pro His Gly Glu Phe Trp Leu Gly Leu Glu Lys Val 
    210                 215                 220                 


His Ser Ile Thr Gly Asp Arg Asn Ser Arg Leu Ala Val Gln Leu Arg 
225                 230                 235                 240 


Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln Phe Ser Val His Leu Gly 
                245                 250                 255     


Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu Thr Ala Pro Val Ala Gly 
            260                 265                 270         


Gln Leu Gly Ala Thr Thr Val Pro Pro Ser Gly Leu Ser Val Pro Phe 
        275                 280                 285             


Ser Thr Trp Asp Gln Asp His Asp Leu Arg Arg Asp Lys Asn Cys Ala 
    290                 295                 300                 


Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly Thr Cys Ser His Ser Asn 
305                 310                 315                 320 


Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro Gln Gln Arg Gln Lys Leu 
                325                 330                 335     


Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg Gly Arg Tyr Tyr Pro Leu 
            340                 345                 350         


Gln Ala Thr Thr Met Leu Ile Gln Pro Met Ala Ala Glu Ala Ala Ser 
        355                 360                 365             


<210>  4
<211>  1853
<212>  DNA
<213>  Homo sapiens

<400>  4
ataaaaaccg tcctcgggcg cggcggggag aagccgagct gagcggatcc tcacacgact       60

gtgatccgat tctttccagc ggcttctgca accaagcggg tcttaccccc ggtcctccgc      120

gtctccagtc ctcgcacctg gaaccccaac gtccccgaga gtccccgaat ccccgctccc      180

aggctaccta agaggatgag cggtgctccg acggccgggg cagccctgat gctctgcgcc      240

gccaccgccg tgctactgag cgctcagggc ggacccgtgc agtccaagtc gccgcgcttt      300

gcgtcctggg acgagatgaa tgtcctggcg cacggactcc tgcagctcgg ccaggggctg      360

cgcgaacacg cggagcgcac ccgcagtcag ctgagcgcgc tggagcggcg cctgagcgcg      420

tgcgggtccg cctgtcaggg aaccgagggg tccaccgacc tcccgttagc ccctgagagc      480

cgggtggacc ctgaggtcct tcacagcctg cagacacaac tcaaggctca gaacagcagg      540

atccagcaac tcttccacaa ggtggcccag cagcagcggc acctggagaa gcagcacctg      600

cgaattcagc atctgcaaag ccagtttggc ctcctggacc acaagcacct agaccatgag      660

gtggccaagc ctgcccgaag aaagaggctg cccgagatgg cccagccagt tgacccggct      720

cacaatgtca gccgcctgca ccatggaggc tggacagtaa ttcagaggcg ccacgatggc      780

tcagtggact tcaaccggcc ctgggaagcc tacaaggcgg ggtttgggga tccccacggc      840

gagttctggc tgggtctgga gaaggtgcat agcatcacgg gggaccgcaa cagccgcctg      900

gccgtgcagc tgcgggactg ggatggcaac gccgagttgc tgcagttctc cgtgcacctg      960

ggtggcgagg acacggccta tagcctgcag ctcactgcac ccgtggccgg ccagctgggc     1020

gccaccaccg tcccacccag cggcctctcc gtacccttct ccacttggga ccaggatcac     1080

gacctccgca gggacaagaa ctgcgccaag agcctctctg gaggctggtg gtttggcacc     1140

tgcagccatt ccaacctcaa cggccagtac ttccgctcca tcccacagca gcggcagaag     1200

cttaagaagg gaatcttctg gaagacctgg cggggccgct actacccgct gcaggccacc     1260

accatgttga tccagcccat ggcagcagag gcagcctcct agcgtcctgg ctgggcctgg     1320

tcccaggccc acgaaagacg gtgactcttg gctctgcccg aggatgtggc cgttccctgc     1380

ctgggcaggg gctccaagga ggggccatct ggaaacttgt ggacagagaa gaagaccacg     1440

actggagaag ccccctttct gagtgcaggg gggctgcatg cgttgcctcc tgagatcgag     1500

gctgcaggat atgctcagac tctagaggcg tggaccaagg ggcatggagc ttcactcctt     1560

gctggccagg gagttgggga ctcagaggga ccacttgggg ccagccagac tggcctcaat     1620

ggcggactca gtcacattga ctgacgggga ccagggcttg tgtgggtcga gagcgccctc     1680

atggtgctgg tgctgttgtg tgtaggtccc ctggggacac aagcaggcgc caatggtatc     1740

tgggcggagc tcacagagtt cttggaataa aagcaacctc agaacactta aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1853


<210>  5
<211>  405
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Met Arg Cys Ala Pro Thr Ala Gly Ala Ala Leu Val Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Gly Leu Leu Ser Ala Gln Gly Arg Pro Ala Gln Pro Glu Pro 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Leu Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly His Gly Leu Arg Glu His Val Glu Arg Thr Arg Gly 
    50                  55                  60                  


Gln Leu Gly Ala Leu Glu Arg Arg Met Ala Ala Cys Gly Asn Ala Cys 
65                  70                  75                  80  


Gln Gly Pro Lys Gly Thr Asp Pro Lys Asp Arg Val Pro Glu Gly Gln 
                85                  90                  95      


Ala Pro Glu Thr Leu Gln Ser Leu Gln Thr Gln Leu Lys Ala Gln Asn 
            100                 105                 110         


Ser Lys Ile Gln Gln Leu Phe Gln Lys Val Ala Gln Gln Gln Arg Tyr 
        115                 120                 125             


Leu Ser Lys Gln Asn Leu Arg Ile Gln Asn Leu Gln Ser Gln Ile Asp 
    130                 135                 140                 


Leu Leu Thr Pro Thr His Leu Asp Asn Gly Val Asp Lys Thr Ser Arg 
145                 150                 155                 160 


Gly Lys Arg Leu Pro Lys Met Ala Gln Leu Ile Gly Leu Thr Pro Asn 
                165                 170                 175     


Ala Thr Arg Leu His Arg Pro Pro Arg Asp Cys Gln Glu Leu Phe Gln 
            180                 185                 190         


Glu Gly Glu Arg His Ser Gly Leu Phe Gln Ile Gln Pro Leu Gly Ser 
        195                 200                 205             


Pro Pro Phe Leu Val Asn Cys Glu Met Thr Ser Asp Gly Gly Trp Thr 
    210                 215                 220                 


Val Ile Gln Arg Arg Leu Asn Gly Ser Val Asp Phe Asn Gln Ser Trp 
225                 230                 235                 240 


Glu Ala Tyr Lys Asp Gly Phe Gly Asp Pro Gln Gly Glu Phe Trp Leu 
                245                 250                 255     


Gly Leu Glu Lys Met His Ser Ile Thr Gly Asp Arg Gly Ser Gln Leu 
            260                 265                 270         


Ala Val Gln Leu Gln Asp Trp Asp Gly Asn Ala Lys Leu Leu Gln Phe 
        275                 280                 285             


Pro Ile His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu Thr 
    290                 295                 300                 


Glu Pro Thr Ala Asn Glu Leu Gly Ala Thr Asn Val Ser Pro Asn Gly 
305                 310                 315                 320 


Leu Ser Leu Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg Gly 
                325                 330                 335     


Asp Leu Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly Thr 
            340                 345                 350         


Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe His Ser Ile Pro Arg 
        355                 360                 365             


Gln Arg Gln Gln Arg Lys Lys Gly Ile Phe Trp Lys Thr Trp Lys Gly 
    370                 375                 380                 


Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Leu Leu Ile Gln Pro Met Glu 
385                 390                 395                 400 


Ala Thr Ala Ala Ser 
                405 


<210>  6
<211>  1218
<212>  DNA
<213>  Rattus norvegicus

<400>  6
atgcgctgcg ctccgaccgc aggcgctgct ctagtgctat gcgcagctac tgcggggctg       60

ctgagcgcgc aagggcgccc tgcacagccg gagccgccgc gcttcgcatc ctgggatgaa      120

atgaacttgc tggctcacgg gctgctgcag ctcggtcacg ggctgcggga acacgtggag      180

cgcacccgtg gacagctggg cgcgctggaa cgccgcatgg ctgcctgcgg taacgcttgt      240

caggggccca aggggacaga cccgaaggat agagtccccg aaggccaggc tcctgagact      300

ctgcagagtt tacagactca actcaaggct cagaacagca agatccagca actgttccag      360

aaggtagccc agcagcagag atacctatca aagcagaatc tgagaataca gaatcttcag      420

agccagattg acctcttgac ccccacacac ctagacaatg gggtagacaa gacttcgagg      480

ggaaagaggc ttcccaagat ggcccagctc attggcttga ctcccaacgc cacccgctta      540

cacaggcctc cccgggactg ccaggaactc tttcaagaag gggagcggca cagtggactt      600

ttccagatcc agcctctggg atctccacca tttttggtca actgtgagat gacttcagat      660

ggaggctgga cggtgattca gagacgcctg aacggctctg tggacttcaa tcagtcttgg      720

gaagcctaca aagatggctt cggagatccc caaggcgagt tctggctggg cctagagaag      780

atgcacagca tcacagggga ccgaggaagc cagttggctg tgcagctcca ggactgggat      840

ggcaatgcca aattgctcca atttcctatc catttggggg gtgaggacac agcctacagc      900

ctgcagctca ccgagcccac ggccaatgag ctgggtgcca ccaatgtttc ccccaatggc      960

ctttccctgc ccttctctac ctgggaccaa gaccacgacc tccgagggga ccttaactgt     1020

gccaagagcc tctctggtgg ctggtggttt ggcacctgca gccattccaa tctaaatgga     1080

caatacttcc actctattcc acggcaacgg cagcagcgta aaaaggggat cttctggaaa     1140

acatggaagg gccgctacta tccactacag gctaccaccc tgttgatcca gcccatggag     1200

gctacagcag cctcttag                                                   1218


<210>  7
<211>  410
<212>  PRT
<213>  Mus musculus

<400>  7

Met Arg Cys Ala Pro Thr Ala Gly Ala Ala Leu Val Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Gly Leu Leu Ser Ala Gln Gly Arg Pro Ala Gln Pro Glu Pro 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Leu Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly His Gly Leu Arg Glu His Val Glu Arg Thr Arg Gly 
    50                  55                  60                  


Gln Leu Gly Ala Leu Glu Arg Arg Met Ala Ala Cys Gly Asn Ala Cys 
65                  70                  75                  80  


Gln Gly Pro Lys Gly Lys Asp Ala Pro Phe Lys Asp Ser Glu Asp Arg 
                85                  90                  95      


Val Pro Glu Gly Gln Thr Pro Glu Thr Leu Gln Ser Leu Gln Thr Gln 
            100                 105                 110         


Leu Lys Ala Gln Asn Ser Lys Ile Gln Gln Leu Phe Gln Lys Val Ala 
        115                 120                 125             


Gln Gln Gln Arg Tyr Leu Ser Lys Gln Asn Leu Arg Ile Gln Asn Leu 
    130                 135                 140                 


Gln Ser Gln Ile Asp Leu Leu Ala Pro Thr His Leu Asp Asn Gly Val 
145                 150                 155                 160 


Asp Lys Thr Ser Arg Gly Lys Arg Leu Pro Lys Met Thr Gln Leu Ile 
                165                 170                 175     


Gly Leu Thr Pro Asn Ala Thr His Leu His Arg Pro Pro Arg Asp Cys 
            180                 185                 190         


Gln Glu Leu Phe Gln Glu Gly Glu Arg His Ser Gly Leu Phe Gln Ile 
        195                 200                 205             


Gln Pro Leu Gly Ser Pro Pro Phe Leu Val Asn Cys Glu Met Thr Ser 
    210                 215                 220                 


Asp Gly Gly Trp Thr Val Ile Gln Arg Arg Leu Asn Gly Ser Val Asp 
225                 230                 235                 240 


Phe Asn Gln Ser Trp Glu Ala Tyr Lys Asp Gly Phe Gly Asp Pro Gln 
                245                 250                 255     


Gly Glu Phe Trp Leu Gly Leu Glu Lys Met His Ser Ile Thr Gly Asn 
            260                 265                 270         


Arg Gly Ser Gln Leu Ala Val Gln Leu Gln Asp Trp Asp Gly Asn Ala 
        275                 280                 285             


Lys Leu Leu Gln Phe Pro Ile His Leu Gly Gly Glu Asp Thr Ala Tyr 
    290                 295                 300                 


Ser Leu Gln Leu Thr Glu Pro Thr Ala Asn Glu Leu Gly Ala Thr Asn 
305                 310                 315                 320 


Val Ser Pro Asn Gly Leu Ser Leu Pro Phe Ser Thr Trp Asp Gln Asp 
                325                 330                 335     


His Asp Leu Arg Gly Asp Leu Asn Cys Ala Lys Ser Leu Ser Gly Gly 
            340                 345                 350         


Trp Trp Phe Gly Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe 
        355                 360                 365             


His Ser Ile Pro Arg Gln Arg Gln Glu Arg Lys Lys Gly Ile Phe Trp 
    370                 375                 380                 


Lys Thr Trp Lys Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Leu Leu 
385                 390                 395                 400 


Ile Gln Pro Met Glu Ala Thr Ala Ala Ser 
                405                 410 


<210>  8
<211>  1869
<212>  DNA
<213>  Mus musculus

<400>  8
acgggctcca gatcttcttc tgcaccagag caagtctaag tctgagccgg ctcccccaga       60

actccagctg ctgggtcttg aactcctgcg ttccggagtc ctagcgttgc tgcacccaag      120

gccaccccca gaatcatgcg ctgcgctccg acagcaggcg ctgccctggt gctatgcgcg      180

gctactgcgg ggcttttgag cgcgcaaggg cgccctgcac agccagagcc accgcgcttt      240

gcatcctggg acgagatgaa cttgctggct cacgggctgc tacagctcgg ccatgggctg      300

cgcgaacacg tggagcgcac ccgtgggcag ctgggcgcgc tggagcgccg catggctgcc      360

tgtggtaacg cttgtcaggg gcccaaggga aaagatgcac ccttcaaaga ctccgaggat      420

agagtccctg aaggccagac tcctgagact ctgcagagtt tgcagactca gctcaaggct      480

caaaacagca agatccagca attgttccag aaggtggccc agcagcagag atacctatca      540

aagcagaatc tgagaataca gaatcttcag agccagatag acctcttggc ccccacgcac      600

ctagacaatg gagtagacaa gacttcgagg ggaaagaggc ttcccaagat gacccagctc      660

attggcttga ctcccaacgc cacccactta cacaggccgc cccgggactg ccaggaactc      720

ttccaagaag gggagaggca cagtggactt ttccagatcc agcctctggg gtctccacca      780

tttttggtca actgtgagat gacttcagat ggaggctgga cagtgattca gagacgcctg      840

aacggctctg tggacttcaa ccagtcctgg gaagcctaca aggatggctt cggagatccc      900

caaggcgagt tctggctggg cctggaaaag atgcacagca tcacagggaa ccgaggaagc      960

caattggctg tgcagctcca ggactgggat ggcaatgcca aattgctcca atttcccatc     1020

catttggggg gtgaggacac agcctacagc ctgcagctca ctgagcccac ggccaatgag     1080

ctgggtgcca ccaatgtttc ccccaatggc ctttccctgc ccttctctac ttgggaccaa     1140

gaccatgacc tccgtgggga ccttaactgt gccaagagcc tctctggtgg ctggtggttt     1200

ggtacctgta gccattccaa tctcaatgga caatacttcc actctatccc acggcaacgg     1260

caggagcgta aaaagggtat cttctggaaa acatggaagg gccgctacta tcctctgcag     1320

gctaccaccc tgctgatcca gcccatggag gctacagcag cctcttagcc tcctcactgg     1380

agcctggttc caggcctaag aagacagtga ctttggttgt ggccctgaga tttggccatt     1440

ctctgctggg ggcaggagct ctaagtaggg ctatctgcgt cttgtggaca aagaagaagc     1500

ccgtaactgg agagactgga ggaccccttt tccgtgttgg ggtctgcaag cattgttgtc     1560

tgaaacagtc agagcaacag gaaacaaatg gcccagatcc agaaaacatg ggctcgaggg     1620

gcactgaata tcacttctcg cctaccagag aagttgggga tgcagaggga ccactacagt     1680

ccaactagct gggcccttaa tggcggactc agtcatattg actgactgga gacagggtgc     1740

caggagccct ggatacactc atggtgctgt tgtaggtgct gtggatgcac aggtgctaac     1800

tgtggttccc aggcacaact cacagcattc ttacaataaa aacaacctca gaacaaaaaa     1860

aaaaaaaaa                                                             1869


<210>  9
<211>  406
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  x = A, K, E or D

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  x = A, K, E or D

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  x = A or S

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  x = A or S

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  misc_feature
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Xaa Xaa Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Xaa Gly Ser Ala Xaa 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu Leu Phe 
            180                 185                 190         


Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro Gln Gly 
        195                 200                 205             


Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Xaa Gly Gly Trp 
    210                 215                 220                 


Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn Arg Pro 
225                 230                 235                 240 


Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu Phe Trp 
                245                 250                 255     


Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn Ser Arg 
            260                 265                 270         


Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln 
        275                 280                 285             


Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu 
    290                 295                 300                 


Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro Pro Ser 
305                 310                 315                 320 


Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp Leu Arg 
                325                 330                 335     


Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly 
            340                 345                 350         


Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro 
        355                 360                 365             


Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg 
    370                 375                 380                 


Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln Pro Met 
385                 390                 395                 400 


Ala Ala Glu Ala Ala Ser 
                405     


<210>  10
<211>  368
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  x = A, K, D or E

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  x = A, K, D or E

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  x = A or C

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  x = A or C

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  MISC_FEATURE
<222>  (163)..(163)
<223>  x = D, R, K, G, A, V or S

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  x = D, R, K, G, A, V or S

<400>  10

Met Ser Gly Ala Pro Thr Ala Gly Ala Ala Leu Met Leu Cys Ala Ala 
1               5                   10                  15      


Thr Ala Val Leu Leu Ser Ala Gln Gly Gly Pro Val Gln Ser Lys Ser 
            20                  25                  30          


Pro Arg Phe Ala Ser Trp Xaa Xaa Met Asn Val Leu Ala His Gly Leu 
        35                  40                  45              


Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr Arg Ser 
    50                  55                  60                  


Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Xaa Gly Ser Ala Xaa 
65                  70                  75                  80  


Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu Ser Arg 
                85                  90                  95      


Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys Ala Gln 
            100                 105                 110         


Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln Gln Arg 
        115                 120                 125             


His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser Gln Phe 
    130                 135                 140                 


Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys Pro Ala 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Leu Pro Glu Met Ala Gln Pro Val Asp Pro Ala His 
                165                 170                 175     


Asn Val Ser Arg Leu His His Gly Gly Trp Thr Val Ile Gln Arg Arg 
            180                 185                 190         


His Asp Gly Ser Val Asp Phe Asn Arg Pro Trp Glu Ala Tyr Lys Ala 
        195                 200                 205             


Gly Phe Gly Asp Pro His Gly Glu Phe Trp Leu Gly Leu Glu Lys Val 
    210                 215                 220                 


His Ser Ile Thr Gly Asp Arg Asn Ser Arg Leu Ala Val Gln Leu Arg 
225                 230                 235                 240 


Asp Trp Asp Gly Asn Ala Glu Leu Leu Gln Phe Ser Val His Leu Gly 
                245                 250                 255     


Gly Glu Asp Thr Ala Tyr Ser Leu Gln Leu Thr Ala Pro Val Ala Gly 
            260                 265                 270         


Gln Leu Gly Ala Thr Thr Val Pro Pro Ser Gly Leu Ser Val Pro Phe 
        275                 280                 285             


Ser Thr Trp Asp Gln Asp His Asp Leu Arg Arg Asp Lys Asn Cys Ala 
    290                 295                 300                 


Lys Ser Leu Ser Gly Gly Trp Trp Phe Gly Thr Cys Ser His Ser Asn 
305                 310                 315                 320 


Leu Asn Gly Gln Tyr Phe Arg Ser Ile Pro Gln Gln Arg Gln Lys Leu 
                325                 330                 335     


Lys Lys Gly Ile Phe Trp Lys Thr Trp Arg Gly Arg Tyr Tyr Pro Leu 
            340                 345                 350         


Gln Ala Thr Thr Met Leu Ile Gln Pro Met Ala Ala Glu Ala Ala Ser 
        355                 360                 365             


<210>  11
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  11
tctgggatct ccaccatttt tg                                                22


<210>  12
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  12
tcaccgtcca gcctccat                                                     18


<210>  13
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  13
caactgtgag atgacttc                                                     18


<210>  14
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  14
cgccacccgc ttacaca                                                      17


<210>  15
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  15
cagaggctgg atctggaaaa gt                                                22


<210>  16
<211>  15
<212>  DNA
<213>  Homo sapiens

<400>  16
tgccaggaac tcttt                                                        15


<210>  17
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  17
tacaggctac caccctgttg atc                                               23


<210>  18
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  18
aaccgcgggc cctctag                                                      17


<210>  19
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  19
ccatggaggc tacagca                                                      17


<210>  20
<211>  27
<212>  DNA
<213>  Homo sapiens

<400>  20
cttgaaggga ttgaaaagat aattagc                                           27


<210>  21
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  21
ccatgagtca gaaaagcatt gaac                                              24


<210>  22
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  22
aggtgagcat tttcctg                                                      17


