                         SEQUENCE LISTING

<110>  Abraxis BioSciences, LLC
       Trieu, Vuong
       Liu, Xiping
       Neil, Desai
 
<120>  PERIPHERAL BLOOD SPARC BINDING ANTIBODIES AND USES THEREOF

<130>  708292

<150>  61/351,246
<151>  2010-06-03

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr Trp Val Glu Trp Val Lys 
1               5                   10                  15      


Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly 
            20                  25                  30          


Ile Ser Ser Thr Asn Tyr Asp Glu Lys Phe Lys Asp Lys Ala Thr Phe 
        35                  40                  45              


Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu 
    50                  55                  60                  


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ser Arg Gly Arg Pro Ala 
65                  70                  75                  80  


Trp Ser Ala Phe Trp Gly Gln Gly Thr Thr Val Thr 
                85                  90          


<210>  2
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp His Ala Trp Ser Trp Ile 
1               5                   10                  15      


Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr 
            20                  25                  30          


Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser Val 
        35                  40                  45              


Thr Arg Asp Thr Ser Lys Asn His Phe Phe Leu Gln Leu Asn Ser Val 
    50                  55                  60                  


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Ala Ala Phe Ile 
65                  70                  75                  80  


Gly Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
                85                  90          


<210>  3
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp His Ala Trp Ser Trp Ile 
1               5                   10                  15      


Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr 
            20                  25                  30          


Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg Val Ser Val 
        35                  40                  45              


Thr Arg Asp Thr Ser Lys Asn His Phe Phe Leu Gln Leu Asn Ser Val 
    50                  55                  60                  


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Ala Ala Phe Ile 
65                  70                  75                  80  


Gly Gly Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr 
                85                  90          


<210>  4
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr Asp Met Ser Trp Val Arg 
1               5                   10                  15      


Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala Tyr Ile Thr Ser Gly 
            20                  25                  30          


Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val Lys Gly Arg Phe Thr Ile 
        35                  40                  45              


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu 
    50                  55                  60                  


Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Gly Ser Arg Ser Trp 
65                  70                  75                  80  


Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
                85                  90          


<210>  5
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp Ser Ala Trp Asn Trp Ile 
1               5                   10                  15      


Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly His Ile Ser Tyr 
            20                  25                  30          


Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile 
        35                  40                  45              


Thr Arg Asp Thr Ser Lys Asp Gln Phe Phe Leu Gln Leu Asn Ser Val 
    50                  55                  60                  


Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Gly Ser Tyr Tyr 
65                  70                  75                  80  


Gly Asn Phe Gly Phe Thr Tyr Trp Gly Gln Gly Thr 
                85                  90          


<210>  6
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr Gly Met Ser Trp Val Arg 
1               5                   10                  15      


Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Thr Ile Ser Ser Gly 
            20                  25                  30          


Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile 
        35                  40                  45              


Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    50                  55                  60                  


Lys Ser Glu Asp Thr Ala Met Tyr Phe Cys Ala Arg Arg Gly Ser Ser 
65                  70                  75                  80  


Gly Asp Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly 
                85                  90          


<210>  7
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr Gly Met Asn Trp Val Lys 
1               5                   10                  15      


Gln Ala Pro Gly Lys Gly Leu Gln Trp Met Gly Trp Ile Asn Thr Asn 
            20                  25                  30          


Thr Gly Glu Pro Thr Tyr Ala Glu Glu Phe Lys Gly Arg Phe Ala Phe 
        35                  40                  45              


Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu 
    50                  55                  60                  


Glu Asn Ala Asp Ser Ala Thr Tyr Phe Cys Thr Arg Gly Ser Ser Tyr 
65                  70                  75                  80  


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
                85                  90          


<210>  8
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gly Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn 
1               5                   10                  15      


Asn Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu 
            20                  25                  30          


Ile Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 
        35                  40                  45              


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu 
    50                  55                  60                  


Thr Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro 
65                  70                  75                  80  


Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
                85                  90          


<210>  9
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
1               5                   10                  15      


Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile 
            20                  25                  30          


Tyr Ser Thr Pro Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala 
    50                  55                  60                  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu 
65                  70                  75                  80  


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gln 
                85                  90          


<210>  10
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Gln Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr 
1               5                   10                  15      


Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Pro Trp Ile 
            20                  25                  30          


Tyr Glu Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
    50                  55                  60                  


Glu Asp Ala Ala Ile Tyr Tyr Cys Gln Gln Trp Asn Tyr Pro Leu Ile 
65                  70                  75                  80  


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg 
                85                  90          


<210>  11
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Gly Glu Gly Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr 
1               5                   10                  15      


Gly Ile His Trp Tyr Gln Arg Arg Thr Asn Gly Ser Pro Arg Leu Leu 
            20                  25                  30          


Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser 
        35                  40                  45              


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Glu 
    50                  55                  60                  


Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Tyr Ser Trp Pro 
65                  70                  75                  80  


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                85                  90          


<210>  12
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gly Glu Thr Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Ala Ser 
1               5                   10                  15      


Asp Leu Ala Trp Tyr Gln Lys Glu Gly Arg Ser Pro Gln Leu Leu Val 
            20                  25                  30          


Tyr Glu Ala Arg Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
        35                  40                  45              


Ser Gly Ser Asp Thr Leu Tyr Ser Leu Asn Ile His Ser Leu Gln Ser 
    50                  55                  60                  


Glu Asp Val Ala Arg Tyr Tyr Cys Gln His Tyr Tyr Gly Thr Pro Trp 
65                  70                  75                  80  


Thr Phe Gly Gly Gly Thr Lys Pro Arg Ala Asn 
                85                  90      


<210>  13
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr 
1               5                   10                  15      


Ser Asn Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            20                  25                  30          


Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly 
        35                  40                  45              


Val Pro Pro Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu 
    50                  55                  60                  


Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln 
65                  70                  75                  80  


Gln Tyr Tyr Ser Phe Pro Arg Thr Phe Gly Gly Gly 
                85                  90          


<210>  14
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gly Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr 
1               5                   10                  15      


Ser Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro 
            20                  25                  30          


Pro Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro 
        35                  40                  45              


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile 
    50                  55                  60                  


His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile 
65                  70                  75                  80  


Arg Glu Leu Thr Arg Ser Val Glu Ala Pro Ser Ser 
                85                  90          


<210>  15
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ile Ala Ala Ala Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Pro Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Val Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr Ser 
    210                 215                 220                 


Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
225                 230                 235                 240 


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
                245                 250                 255     


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
            260                 265                 270         


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
        275                 280                 285             


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
    290                 295                 300                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
305                 310                 315                 320 


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                325                 330                 335     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            340                 345                 350         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        355                 360                 365             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
    370                 375                 380                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
385                 390                 395                 400 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                405                 410                 415     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            420                 425                 430         


Thr Val Ala Pro Thr Glu Cys Ser 
        435                 440 


<210>  16
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Ile Ala Ala Ala Gly Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr Ser 
    210                 215                 220                 


Glu Leu Val Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
225                 230                 235                 240 


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
                245                 250                 255     


Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
            260                 265                 270         


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
        275                 280                 285             


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
    290                 295                 300                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
305                 310                 315                 320 


Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
                325                 330                 335     


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
            340                 345                 350         


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
        355                 360                 365             


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
    370                 375                 380                 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
385                 390                 395                 400 


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
                405                 410                 415     


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
            420                 425                 430         


Thr Val Ala Pro Thr Glu Cys Ser 
        435                 440 


<210>  17
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Ala Glu Leu Val Leu Thr Gln Pro Pro Ser Val 
            20                  25                  30          


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser 
        35                  40                  45              


Ser Asn Ile Gly Ser Asn Tyr Val Tyr Trp Tyr Gln Gln Leu Pro Gly 
    50                  55                  60                  


Thr Ala Pro Lys Leu Leu Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly 
65                  70                  75                  80  


Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu 
                85                  90                  95      


Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala 
            100                 105                 110         


Ala Trp Asp Asp Ser Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala 
                165                 170                 175     


Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys 
            180                 185                 190         


Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 
        195                 200                 205             


Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 
    210                 215                 220                 


Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Met Lys 
225                 230                 235                 240 


Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala Gln 
                245                 250                 255     


Pro Ala Met Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        275                 280                 285             


Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    290                 295                 300                 


Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                325                 330                 335     


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Arg Gly Ile Ala Ala Ala Gly Leu Asp Tyr Trp Gly 
        355                 360                 365             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    370                 375                 380                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
385                 390                 395                 400 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                405                 410                 415     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            420                 425                 430         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        435                 440                 445             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    450                 455                 460                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
465                 470                 475                 480 


Asp Lys Thr Ser Gly Gln Ala Gly Gln His His His His His His Gly 
                485                 490                 495     


Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
            500                 505         


