                         SEQUENCE LISTING

<110>  University of Kentucky Research Foundation
 
<120>  METHODS OF INHIBITING ALU RNA AND THERAPEUTIC USES THEREOF

<130>  13177N-1736WO

<150>  US 61/396,747
<151>  2010-06-01

<150>  US 61/432,110
<151>  2011-01-12

<150>  US 61/432,948
<151>  2011-01-14

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  1
ctcagcctca cgagtagct                                                    19


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  2
tgggactaca ggcgcccga                                                    19


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  3
gcctcagcct cacgagtagc t                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  4
gctgggacta caggcgcccg a                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  5
gggactacag gcgcccgaca c                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  6
acaggcgccc gacaccactc c                                                 21


<210>  7
<211>  10323
<212>  DNA
<213>  Homo sapiens

<400>  7
cggaggcgcg gcgcaggctg ctgcaggccc aggtgaatgg agtaacctga cagcggggac       60

gaggcgacgg cgagcgcgag gaaatggcgg cgggggcggc ggcgccgggc ggctccggga      120

ggcctgggct gtgacgcgcg cgccggagcg gggtccgatg gttctcgaag gcccgcggcg      180

ccccgtgctg cagtaagctg tgctagaaca aaaatgcaat gaaagaaaca ctggatgaat      240

gaaaagccct gctttgcaac ccctcagcat ggcaggcctg cagctcatga cccctgcttc      300

ctcaccaatg ggtcctttct ttggactgcc atggcaacaa gaagcaattc atgataacat      360

ttatacgcca agaaaatatc aggttgaact gcttgaagca gctctggatc ataataccat      420

cgtctgttta aacactggct cagggaagac atttattgca gtactactca ctaaagagct      480

gtcctatcag atcaggggag acttcagcag aaatggaaaa aggacggtgt tcttggtcaa      540

ctctgcaaac caggttgctc aacaagtgtc agctgtcaga actcattcag atctcaaggt      600

tggggaatac tcaaacctag aagtaaatgc atcttggaca aaagagagat ggaaccaaga      660

gtttactaag caccaggttc tcattatgac ttgctatgtc gccttgaatg ttttgaaaaa      720

tggttactta tcactgtcag acattaacct tttggtgttt gatgagtgtc atcttgcaat      780

cctagaccac ccctatcgag aaattatgaa gctctgtgaa aattgtccat catgtcctcg      840

cattttggga ctaactgctt ccattttaaa tgggaaatgt gatccagagg aattggaaga      900

aaagattcag aaactagaga aaattcttaa gagtaatgct gaaactgcaa ctgacctggt      960

ggtcttagac aggtatactt ctcagccatg tgagattgtg gtggattgtg gaccatttac     1020

tgacagaagt gggctttatg aaagactgct gatggaatta gaagaagcac ttaattttat     1080

caatgattgt aatatatctg tacattcaaa agaaagagat tctactttaa tttcgaaaca     1140

gatactatca gactgtcgtg ccgtattggt agttctggga ccctggtgtg cagataaagt     1200

agctggaatg atggtaagag aactacagaa atacatcaaa catgagcaag aggagctgca     1260

caggaaattt ttattgttta cagacacttt cctaaggaaa atacatgcac tatgtgaaga     1320

gcacttctca cctgcctcac ttgacctgaa atttgtaact cctaaagtaa tcaaactgct     1380

cgaaatctta cgcaaatata aaccatatga gcgacagcag tttgaaagcg ttgagtggta     1440

taataataga aatcaggata attatgtgtc atggagtgat tctgaggatg atgatgagga     1500

tgaagaaatt gaagaaaaag agaagccaga gacaaatttt ccttctcctt ttaccaacat     1560

tttgtgcgga attatttttg tggaaagaag atacacagca gttgtcttaa acagattgat     1620

aaaggaagct ggcaaacaag atccagagct ggcttatatc agtagcaatt tcataactgg     1680

acatggcatt gggaagaatc agcctcgcaa caaacagatg gaagcagaat tcagaaaaca     1740

ggaagaggta cttaggaaat ttcgagcaca tgagaccaac ctgcttattg caacaagtat     1800

tgtagaagag ggtgttgata taccaaaatg caacttggtg gttcgttttg atttgcccac     1860

agaatatcga tcctatgttc aatctaaagg aagagcaagg gcacccatct ctaattatat     1920

aatgttagcg gatacagaca aaataaaaag ttttgaagaa gaccttaaaa cctacaaagc     1980

tattgaaaag atcttgagaa acaagtgttc caagtcggtt gatactggtg agactgacat     2040

tgatcctgtc atggatgatg atgacgtttt cccaccatat gtgttgaggc ctgacgatgg     2100

tggtccacga gtcacaatca acacggccat tggacacatc aatagatact gtgctagatt     2160

accaagtgat ccgtttactc atctagctcc taaatgcaga acccgagagt tgcctgatgg     2220

tacattttat tcaactcttt atctgccaat taactcacct cttcgagcct ccattgttgg     2280

tccaccaatg agctgtgtac gattggctga aagagttgta gctctcattt gctgtgagaa     2340

actgcacaaa attggcgaac tggatgacca tttgatgcca gttgggaaag agactgttaa     2400

atatgaagag gagcttgatt tgcatgatga agaagagacc agtgttccag gaagaccagg     2460

ttccacgaaa cgaaggcagt gctacccaaa agcaattcca gagtgtttga gggatagtta     2520

tcccagacct gatcagccct gttacctgta tgtgatagga atggttttaa ctacaccttt     2580

acctgatgaa ctcaacttta gaaggcggaa gctctatcct cctgaagata ccacaagatg     2640

ctttggaata ctgacggcca aacccatacc tcagattcca cactttcctg tgtacacacg     2700

ctctggagag gttaccatat ccattgagtt gaagaagtct ggtttcatgt tgtctctaca     2760

aatgcttgag ttgattacaa gacttcacca gtatatattc tcacatattc ttcggcttga     2820

aaaacctgca ctagaattta aacctacaga cgctgattca gcatactgtg ttctacctct     2880

taatgttgtt aatgactcca gcactttgga tattgacttt aaattcatgg aagatattga     2940

gaagtctgaa gctcgcatag gcattcccag tacaaagtat acaaaagaaa caccctttgt     3000

ttttaaatta gaagattacc aagatgccgt tatcattcca agatatcgca attttgatca     3060

gcctcatcga ttttatgtag ctgatgtgta cactgatctt accccactca gtaaatttcc     3120

ttcccctgag tatgaaactt ttgcagaata ttataaaaca aagtacaacc ttgacctaac     3180

caatctcaac cagccactgc tggatgtgga ccacacatct tcaagactta atcttttgac     3240

acctcgacat ttgaatcaga aggggaaagc gcttccttta agcagtgctg agaagaggaa     3300

agccaaatgg gaaagtctgc agaataaaca gatactggtt ccagaactct gtgctataca     3360

tccaattcca gcatcactgt ggagaaaagc tgtttgtctc cccagcatac tttatcgcct     3420

tcactgcctt ttgactgcag aggagctaag agcccagact gccagcgatg ctggcgtggg     3480

agtcagatca cttcctgcgg attttagata ccctaactta gacttcgggt ggaaaaaatc     3540

tattgacagc aaatctttca tctcaatttc taactcctct tcagctgaaa atgataatta     3600

ctgtaagcac agcacaattg tccctgaaaa tgctgcacat caaggtgcta atagaacctc     3660

ctctctagaa aatcatgacc aaatgtctgt gaactgcaga acgttgctca gcgagtcccc     3720

tggtaagctc cacgttgaag tttcagcaga tcttacagca attaatggtc tttcttacaa     3780

tcaaaatctc gccaatggca gttatgattt agctaacaga gacttttgcc aaggaaatca     3840

gctaaattac tacaagcagg aaatacccgt gcaaccaact acctcatatt ccattcagaa     3900

tttatacagt tacgagaacc agccccagcc cagcgatgaa tgtactctcc tgagtaataa     3960

ataccttgat ggaaatgcta acaaatctac ctcagatgga agtcctgtga tggccgtaat     4020

gcctggtacg acagacacta ttcaagtgct caagggcagg atggattctg agcagagccc     4080

ttctattggg tactcctcaa ggactcttgg ccccaatcct ggacttattc ttcaggcttt     4140

gactctgtca aacgctagtg atggatttaa cctggagcgg cttgaaatgc ttggcgactc     4200

ctttttaaag catgccatca ccacatatct attttgcact taccctgatg cgcatgaggg     4260

ccgcctttca tatatgagaa gcaaaaaggt cagcaactgt aatctgtatc gccttggaaa     4320

aaagaaggga ctacccagcc gcatggtggt gtcaatattt gatccccctg tgaattggct     4380

tcctcctggt tatgtagtaa atcaagacaa aagcaacaca gataaatggg aaaaagatga     4440

aatgacaaaa gactgcatgc tggcgaatgg caaactggat gaggattacg aggaggagga     4500

tgaggaggag gagagcctga tgtggagggc tccgaaggaa gaggctgact atgaagatga     4560

tttcctggag tatgatcagg aacatatcag atttatagat aatatgttaa tggggtcagg     4620

agcttttgta aagaaaatct ctctttctcc tttttcaacc actgattctg catatgaatg     4680

gaaaatgccc aaaaaatcct ccttaggtag tatgccattt tcatcagatt ttgaggattt     4740

tgactacagc tcttgggatg caatgtgcta tctggatcct agcaaagctg ttgaagaaga     4800

tgactttgtg gtggggttct ggaatccatc agaagaaaac tgtggtgttg acacgggaaa     4860

gcagtccatt tcttacgact tgcacactga gcagtgtatt gctgacaaaa gcatagcgga     4920

ctgtgtggaa gccctgctgg gctgctattt aaccagctgt ggggagaggg ctgctcagct     4980

tttcctctgt tcactggggc tgaaggtgct cccggtaatt aaaaggactg atcgggaaaa     5040

ggccctgtgc cctactcggg agaatttcaa cagccaacaa aagaaccttt cagtgagctg     5100

tgctgctgct tctgtggcca gttcacgctc ttctgtattg aaagactcgg aatatggttg     5160

tttgaagatt ccaccaagat gtatgtttga tcatccagat gcagataaaa cactgaatca     5220

ccttatatcg gggtttgaaa attttgaaaa gaaaatcaac tacagattca agaataaggc     5280

ttaccttctc caggctttta cacatgcctc ctaccactac aatactatca ctgattgtta     5340

ccagcgctta gaattcctgg gagatgcgat tttggactac ctcataacca agcaccttta     5400

tgaagacccg cggcagcact ccccgggggt cctgacagac ctgcggtctg ccctggtcaa     5460

caacaccatc tttgcatcgc tggctgtaaa gtacgactac cacaagtact tcaaagctgt     5520

ctctcctgag ctcttccatg tcattgatga ctttgtgcag tttcagcttg agaagaatga     5580

aatgcaagga atggattctg agcttaggag atctgaggag gatgaagaga aagaagagga     5640

tattgaagtt ccaaaggcca tgggggatat ttttgagtcg cttgctggtg ccatttacat     5700

ggatagtggg atgtcactgg agacagtctg gcaggtgtac tatcccatga tgcggccact     5760

aatagaaaag ttttctgcaa atgtaccccg ttcccctgtg cgagaattgc ttgaaatgga     5820

accagaaact gccaaattta gcccggctga gagaacttac gacgggaagg tcagagtcac     5880

tgtggaagta gtaggaaagg ggaaatttaa aggtgttggt cgaagttaca ggattgccaa     5940

atctgcagca gcaagaagag ccctccgaag cctcaaagct aatcaacctc aggttcccaa     6000

tagctgaaac cgctttttaa aattcaaaac aagaaacaaa acaaaaaaaa ttaaggggaa     6060

aattatttaa atcggaaagg aagacttaaa gttgttagtg agtggaatga attgaaggca     6120

gaatttaaag tttggttgat aacaggatag ataacagaat aaaacattta acatatgtat     6180

aaaattttgg aactaattgt agttttagtt ttttgcgcaa acacaatctt atcttctttc     6240

ctcacttctg ctttgtttaa atcacaagag tgctttaatg atgacattta gcaagtgctc     6300

aaaataattg acaggttttg tttttttttt tttgagttta tgtcagcttt gcttagtgtt     6360

agaaggccat ggagcttaaa cctccagcag tccctaggat gatgtagatt cttctccatc     6420

tctccgtgtg tgcagtagtg ccagtcctgc agtagttgat aagctgaata gaaagataag     6480

gttttcgaga ggagaagtgc gccaatgttg tcttttcttt ccacgttata ctgtgtaagg     6540

tgatgttccc ggtcgctgtt gcacctgata gtaagggaca gatttttaat gaacattggc     6600

tggcatgttg gtgaatcaca ttttagtttt ctgatgccac atagtcttgc ataaaaaagg     6660

gttcttgcct taaaagtgaa accttcatgg atagtcttta atctctgatc tttttggaac     6720

aaactgtttt acattccttt cattttatta tgcattagac gttgagacag cgtgatactt     6780

acaactcact agtatagttg taacttatta caggatcata ctaaaatttc tgtcatatgt     6840

atactgaaga cattttaaaa accagaatat gtagtctacg gatatttttt atcataaaaa     6900

tgatctttgg ctaaacaccc cattttacta aagtcctcct gccaggtagt tcccactgat     6960

ggaaatgttt atggcaaata attttgcctt ctaggctgtt gctctaacaa aataaacctt     7020

agacatatca cacctaaaat atgctgcaga ttttataatt gattggttac ttatttaaga     7080

agcaaaacac agcaccttta cccttagtct cctcacataa atttcttact atacttttca     7140

taatgttgca tgcatatttc acctaccaaa gctgtgctgt taatgccgtg aaagtttaac     7200

gtttgcgata aactgccgta attttgatac atctgtgatt taggtcatta atttagataa     7260

actagctcat tatttccatc tttggaaaag gaaaaaaaaa aaaacttctt taggcatttg     7320

cctaagtttc tttaattaga cttgtaggca ctcttcactt aaatacctca gttcttcttt     7380

tcttttgcat gcatttttcc cctgtttggt gctatgttta tgtattatgc ttgaaatttt     7440

aatttttttt tttttgcact gtaactataa tacctcttaa tttacctttt taaaagctgt     7500

gggtcagtct tgcactccca tcaacatacc agtagaggtt tgctgcaatt tgccccgtta     7560

attatgcttg aagtttaaga aagctgagca gaggtgtctc atatttccca gcacatgatt     7620

ctgaacttga tgcttcgtgg aatgctgcat ttatatgtaa gtgacatttg aatactgtcc     7680

ttcctgcttt atctgcatca tccacccaca gagaaatgcc tctgtgcgag tgcaccgaca     7740

gaaaactgtc agctctgctt tctaaggaac cctgagtgag gggggtatta agcttctcca     7800

gtgttttttg ttgtctccaa tcttaaactt aaattgagat ctaaattatt aaacgagttt     7860

ttgagcaaat taggtgactt gttttaaaaa tatttaattc cgatttggaa ccttagatgt     7920

ctatttgatt ttttaaaaaa ccttaatgta agatatgacc agttaaaaca aagcaattct     7980

tgaattatat aactgtaaaa gtgtgcagtt aacaaggctg gatgtgaatt ttattctgag     8040

ggtgatttgt gatcaagttt aatcacaaat ctcttaatat ttataaacta cctgatgcca     8100

ggagcttagg gctttgcatt gtgtctaata cattgatccc agtgttacgg gattctcttg     8160

attcctggca ccaaaatcag attgttttca cagttatgat tcccagtggg agaaaaatgc     8220

ctcaatatat ttgtaacctt aagaagagta tttttttgtt aatactaaga tgttcaaact     8280

tagacatgat taggtcatac attctcaggg gttcaaattt ccttctacca ttcaaatgtt     8340

ttatcaacag caaacttcag ccgtttcact ttttgttgga gaaaaatagt agattttaat     8400

ttgactcaca gtttgaagca ttctgtgatc ccctggttac tgagttaaaa aataaaaaag     8460

tacgagttag acatatgaaa tggttatgaa cgcttttgtg ctgctgattt ttaatgctgt     8520

aaagttttcc tgtgtttagc ttgttgaaat gttttgcatc tgtcaattaa ggaaaaaaaa     8580

aatcactcta tgttgcccca ctttagagcc ctgtgtgcca ccctgtgttc ctgtgattgc     8640

aatgtgagac cgaatgtaat atggaaaacc taccagtggg gtgtggttgt gccctgagca     8700

cgtgtgtaaa ggactgggga ggcgtgtctt gaaaaagcaa ctgcagaaat tccttatgat     8760

gattgtgtgc aagttagtta acatgaacct tcatttgtaa attttttaaa atttctttta     8820

taatatgctt tccgcagtcc taactatgct gcgttttata atagcttttt cccttctgtt     8880

ctgttcatgt agcacagata agcattgcac ttggtaccat gctttacctc atttcaagaa     8940

aatatgctta acagagagga aaaaaatgtg gtttggcctt gctgctgttt tgatttatgg     9000

aatttgaaaa agataattat aatgcctgca atgtgtcata tactcgcaca acttaaatag     9060

gtcatttttg tctgtggcat ttttactgtt tgtgaaagta tgaaacagat ttgttaactg     9120

aactcttaat tatgttttta aaatgtttgt tatatttctt ttcttttttc ttttatatta     9180

cgtgaagtga tgaaatttag aatgacctct aacactcctg taattgtctt ttaaaatact     9240

gatattttta tttgttaata atactttgcc ctcagaaaga ttctgatacc ctgccttgac     9300

aacatgaaac ttgaggctgc tttggttcat gaatccaggt gttcccccgg cagtcggctt     9360

cttcagtcgc tccctggagg caggtgggca ctgcagagga tcactggaat ccagatcgag     9420

cgcagttcat gcacaaggcc ccgttgattt aaaatattgg atcttgctct gttagggtgt     9480

ctaatccctt tacacaagat tgaagccacc aaactgagac cttgatacct ttttttaact     9540

gcatctgaaa ttatgttaag agtctttaac ccatttgcat tatctgcaga agagaaactc     9600

atgtcatgtt tattacctat atggttgttt taattacatt tgaataatta tatttttcca     9660

accactgatt acttttcagg aatttaatta tttccagata aatttcttta ttttatattg     9720

tacatgaaaa gttttaaaga tatgtttaag accaagacta ttaaaatgat ttttaaagtt     9780

gttggagacg ccaatagcaa tatctaggaa atttgcattg agaccattgt attttccact     9840

agcagtgaaa atgatttttc acaactaact tgtaaatata ttttaatcat tacttctttt     9900

tttctagtcc atttttattt ggacatcaac cacagacaat ttaaatttta tagatgcact     9960

aagaattcac tgcagcagca ggttacatag caaaaatgca aaggtgaaca ggaagtaaat    10020

ttctggcttt tctgctgtaa atagtgaagg aaaattacta aaatcaagta aaactaatgc    10080

atattatttg attgacaata aaatatttac catcacatgc tgcagctgtt ttttaaggaa    10140

catgatgtca ttcattcata cagtaatcat gctgcagaaa tttgcagtct gcaccttatg    10200

gatcacaatt acctttagtt gttttttttg taataattgt agccaagtaa atctccaata    10260

aagttatcgt ctgttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    10320

aaa                                                                  10323


<210>  8
<211>  10220
<212>  DNA
<213>  Homo sapiens

<400>  8
ggaaactctg aaagaactta gaatcagcat tttgagagca gaagcttggg catgctgtga       60

ttttccaata aactgctatc acaatgtcaa aatgcagttc agacaagagc aacacagaga      120

tctcaaacat taaaacgtaa gctgtgctag aacaaaaatg caatgaaaga aacactggat      180

gaatgaaaag ccctgctttg caacccctca gcatggcagg cctgcagctc atgacccctg      240

cttcctcacc aatgggtcct ttctttggac tgccatggca acaagaagca attcatgata      300

acatttatac gccaagaaaa tatcaggttg aactgcttga agcagctctg gatcataata      360

ccatcgtctg tttaaacact ggctcaggga agacatttat tgcagtacta ctcactaaag      420

agctgtccta tcagatcagg ggagacttca gcagaaatgg aaaaaggacg gtgttcttgg      480

tcaactctgc aaaccaggtt gctcaacaag tgtcagctgt cagaactcat tcagatctca      540

aggttgggga atactcaaac ctagaagtaa atgcatcttg gacaaaagag agatggaacc      600

aagagtttac taagcaccag gttctcatta tgacttgcta tgtcgccttg aatgttttga      660

aaaatggtta cttatcactg tcagacatta accttttggt gtttgatgag tgtcatcttg      720

caatcctaga ccacccctat cgagaaatta tgaagctctg tgaaaattgt ccatcatgtc      780

ctcgcatttt gggactaact gcttccattt taaatgggaa atgtgatcca gaggaattgg      840

aagaaaagat tcagaaacta gagaaaattc ttaagagtaa tgctgaaact gcaactgacc      900

tggtggtctt agacaggtat acttctcagc catgtgagat tgtggtggat tgtggaccat      960

ttactgacag aagtgggctt tatgaaagac tgctgatgga attagaagaa gcacttaatt     1020

ttatcaatga ttgtaatata tctgtacatt caaaagaaag agattctact ttaatttcga     1080

aacagatact atcagactgt cgtgccgtat tggtagttct gggaccctgg tgtgcagata     1140

aagtagctgg aatgatggta agagaactac agaaatacat caaacatgag caagaggagc     1200

tgcacaggaa atttttattg tttacagaca ctttcctaag gaaaatacat gcactatgtg     1260

aagagcactt ctcacctgcc tcacttgacc tgaaatttgt aactcctaaa gtaatcaaac     1320

tgctcgaaat cttacgcaaa tataaaccat atgagcgaca gcagtttgaa agcgttgagt     1380

ggtataataa tagaaatcag gataattatg tgtcatggag tgattctgag gatgatgatg     1440

aggatgaaga aattgaagaa aaagagaagc cagagacaaa ttttccttct ccttttacca     1500

acattttgtg cggaattatt tttgtggaaa gaagatacac agcagttgtc ttaaacagat     1560

tgataaagga agctggcaaa caagatccag agctggctta tatcagtagc aatttcataa     1620

ctggacatgg cattgggaag aatcagcctc gcaacaaaca gatggaagca gaattcagaa     1680

aacaggaaga ggtacttagg aaatttcgag cacatgagac caacctgctt attgcaacaa     1740

gtattgtaga agagggtgtt gatataccaa aatgcaactt ggtggttcgt tttgatttgc     1800

ccacagaata tcgatcctat gttcaatcta aaggaagagc aagggcaccc atctctaatt     1860

atataatgtt agcggataca gacaaaataa aaagttttga agaagacctt aaaacctaca     1920

aagctattga aaagatcttg agaaacaagt gttccaagtc ggttgatact ggtgagactg     1980

acattgatcc tgtcatggat gatgatgacg ttttcccacc atatgtgttg aggcctgacg     2040

atggtggtcc acgagtcaca atcaacacgg ccattggaca catcaataga tactgtgcta     2100

gattaccaag tgatccgttt actcatctag ctcctaaatg cagaacccga gagttgcctg     2160

atggtacatt ttattcaact ctttatctgc caattaactc acctcttcga gcctccattg     2220

ttggtccacc aatgagctgt gtacgattgg ctgaaagagt tgtagctctc atttgctgtg     2280

agaaactgca caaaattggc gaactggatg accatttgat gccagttggg aaagagactg     2340

ttaaatatga agaggagctt gatttgcatg atgaagaaga gaccagtgtt ccaggaagac     2400

caggttccac gaaacgaagg cagtgctacc caaaagcaat tccagagtgt ttgagggata     2460

gttatcccag acctgatcag ccctgttacc tgtatgtgat aggaatggtt ttaactacac     2520

ctttacctga tgaactcaac tttagaaggc ggaagctcta tcctcctgaa gataccacaa     2580

gatgctttgg aatactgacg gccaaaccca tacctcagat tccacacttt cctgtgtaca     2640

cacgctctgg agaggttacc atatccattg agttgaagaa gtctggtttc atgttgtctc     2700

tacaaatgct tgagttgatt acaagacttc accagtatat attctcacat attcttcggc     2760

ttgaaaaacc tgcactagaa tttaaaccta cagacgctga ttcagcatac tgtgttctac     2820

ctcttaatgt tgttaatgac tccagcactt tggatattga ctttaaattc atggaagata     2880

ttgagaagtc tgaagctcgc ataggcattc ccagtacaaa gtatacaaaa gaaacaccct     2940

ttgtttttaa attagaagat taccaagatg ccgttatcat tccaagatat cgcaattttg     3000

atcagcctca tcgattttat gtagctgatg tgtacactga tcttacccca ctcagtaaat     3060

ttccttcccc tgagtatgaa acttttgcag aatattataa aacaaagtac aaccttgacc     3120

taaccaatct caaccagcca ctgctggatg tggaccacac atcttcaaga cttaatcttt     3180

tgacacctcg acatttgaat cagaagggga aagcgcttcc tttaagcagt gctgagaaga     3240

ggaaagccaa atgggaaagt ctgcagaata aacagatact ggttccagaa ctctgtgcta     3300

tacatccaat tccagcatca ctgtggagaa aagctgtttg tctccccagc atactttatc     3360

gccttcactg ccttttgact gcagaggagc taagagccca gactgccagc gatgctggcg     3420

tgggagtcag atcacttcct gcggatttta gataccctaa cttagacttc gggtggaaaa     3480

aatctattga cagcaaatct ttcatctcaa tttctaactc ctcttcagct gaaaatgata     3540

attactgtaa gcacagcaca attgtccctg aaaatgctgc acatcaaggt gctaatagaa     3600

cctcctctct agaaaatcat gaccaaatgt ctgtgaactg cagaacgttg ctcagcgagt     3660

cccctggtaa gctccacgtt gaagtttcag cagatcttac agcaattaat ggtctttctt     3720

acaatcaaaa tctcgccaat ggcagttatg atttagctaa cagagacttt tgccaaggaa     3780

atcagctaaa ttactacaag caggaaatac ccgtgcaacc aactacctca tattccattc     3840

agaatttata cagttacgag aaccagcccc agcccagcga tgaatgtact ctcctgagta     3900

ataaatacct tgatggaaat gctaacaaat ctacctcaga tggaagtcct gtgatggccg     3960

taatgcctgg tacgacagac actattcaag tgctcaaggg caggatggat tctgagcaga     4020

gcccttctat tgggtactcc tcaaggactc ttggccccaa tcctggactt attcttcagg     4080

ctttgactct gtcaaacgct agtgatggat ttaacctgga gcggcttgaa atgcttggcg     4140

actccttttt aaagcatgcc atcaccacat atctattttg cacttaccct gatgcgcatg     4200

agggccgcct ttcatatatg agaagcaaaa aggtcagcaa ctgtaatctg tatcgccttg     4260

gaaaaaagaa gggactaccc agccgcatgg tggtgtcaat atttgatccc cctgtgaatt     4320

ggcttcctcc tggttatgta gtaaatcaag acaaaagcaa cacagataaa tgggaaaaag     4380

atgaaatgac aaaagactgc atgctggcga atggcaaact ggatgaggat tacgaggagg     4440

aggatgagga ggaggagagc ctgatgtgga gggctccgaa ggaagaggct gactatgaag     4500

atgatttcct ggagtatgat caggaacata tcagatttat agataatatg ttaatggggt     4560

caggagcttt tgtaaagaaa atctctcttt ctcctttttc aaccactgat tctgcatatg     4620

aatggaaaat gcccaaaaaa tcctccttag gtagtatgcc attttcatca gattttgagg     4680

attttgacta cagctcttgg gatgcaatgt gctatctgga tcctagcaaa gctgttgaag     4740

aagatgactt tgtggtgggg ttctggaatc catcagaaga aaactgtggt gttgacacgg     4800

gaaagcagtc catttcttac gacttgcaca ctgagcagtg tattgctgac aaaagcatag     4860

cggactgtgt ggaagccctg ctgggctgct atttaaccag ctgtggggag agggctgctc     4920

agcttttcct ctgttcactg gggctgaagg tgctcccggt aattaaaagg actgatcggg     4980

aaaaggccct gtgccctact cgggagaatt tcaacagcca acaaaagaac ctttcagtga     5040

gctgtgctgc tgcttctgtg gccagttcac gctcttctgt attgaaagac tcggaatatg     5100

gttgtttgaa gattccacca agatgtatgt ttgatcatcc agatgcagat aaaacactga     5160

atcaccttat atcggggttt gaaaattttg aaaagaaaat caactacaga ttcaagaata     5220

aggcttacct tctccaggct tttacacatg cctcctacca ctacaatact atcactgatt     5280

gttaccagcg cttagaattc ctgggagatg cgattttgga ctacctcata accaagcacc     5340

tttatgaaga cccgcggcag cactccccgg gggtcctgac agacctgcgg tctgccctgg     5400

tcaacaacac catctttgca tcgctggctg taaagtacga ctaccacaag tacttcaaag     5460

ctgtctctcc tgagctcttc catgtcattg atgactttgt gcagtttcag cttgagaaga     5520

atgaaatgca aggaatggat tctgagctta ggagatctga ggaggatgaa gagaaagaag     5580

aggatattga agttccaaag gccatggggg atatttttga gtcgcttgct ggtgccattt     5640

acatggatag tgggatgtca ctggagacag tctggcaggt gtactatccc atgatgcggc     5700

cactaataga aaagttttct gcaaatgtac cccgttcccc tgtgcgagaa ttgcttgaaa     5760

tggaaccaga aactgccaaa tttagcccgg ctgagagaac ttacgacggg aaggtcagag     5820

tcactgtgga agtagtagga aaggggaaat ttaaaggtgt tggtcgaagt tacaggattg     5880

ccaaatctgc agcagcaaga agagccctcc gaagcctcaa agctaatcaa cctcaggttc     5940

ccaatagctg aaaccgcttt ttaaaattca aaacaagaaa caaaacaaaa aaaattaagg     6000

ggaaaattat ttaaatcgga aaggaagact taaagttgtt agtgagtgga atgaattgaa     6060

ggcagaattt aaagtttggt tgataacagg atagataaca gaataaaaca tttaacatat     6120

gtataaaatt ttggaactaa ttgtagtttt agttttttgc gcaaacacaa tcttatcttc     6180

tttcctcact tctgctttgt ttaaatcaca agagtgcttt aatgatgaca tttagcaagt     6240

gctcaaaata attgacaggt tttgtttttt tttttttgag tttatgtcag ctttgcttag     6300

tgttagaagg ccatggagct taaacctcca gcagtcccta ggatgatgta gattcttctc     6360

catctctccg tgtgtgcagt agtgccagtc ctgcagtagt tgataagctg aatagaaaga     6420

taaggttttc gagaggagaa gtgcgccaat gttgtctttt ctttccacgt tatactgtgt     6480

aaggtgatgt tcccggtcgc tgttgcacct gatagtaagg gacagatttt taatgaacat     6540

tggctggcat gttggtgaat cacattttag ttttctgatg ccacatagtc ttgcataaaa     6600

aagggttctt gccttaaaag tgaaaccttc atggatagtc tttaatctct gatctttttg     6660

gaacaaactg ttttacattc ctttcatttt attatgcatt agacgttgag acagcgtgat     6720

acttacaact cactagtata gttgtaactt attacaggat catactaaaa tttctgtcat     6780

atgtatactg aagacatttt aaaaaccaga atatgtagtc tacggatatt ttttatcata     6840

aaaatgatct ttggctaaac accccatttt actaaagtcc tcctgccagg tagttcccac     6900

tgatggaaat gtttatggca aataattttg ccttctaggc tgttgctcta acaaaataaa     6960

ccttagacat atcacaccta aaatatgctg cagattttat aattgattgg ttacttattt     7020

aagaagcaaa acacagcacc tttaccctta gtctcctcac ataaatttct tactatactt     7080

ttcataatgt tgcatgcata tttcacctac caaagctgtg ctgttaatgc cgtgaaagtt     7140

taacgtttgc gataaactgc cgtaattttg atacatctgt gatttaggtc attaatttag     7200

ataaactagc tcattatttc catctttgga aaaggaaaaa aaaaaaaact tctttaggca     7260

tttgcctaag tttctttaat tagacttgta ggcactcttc acttaaatac ctcagttctt     7320

cttttctttt gcatgcattt ttcccctgtt tggtgctatg tttatgtatt atgcttgaaa     7380

ttttaatttt tttttttttg cactgtaact ataatacctc ttaatttacc tttttaaaag     7440

ctgtgggtca gtcttgcact cccatcaaca taccagtaga ggtttgctgc aatttgcccc     7500

gttaattatg cttgaagttt aagaaagctg agcagaggtg tctcatattt cccagcacat     7560

gattctgaac ttgatgcttc gtggaatgct gcatttatat gtaagtgaca tttgaatact     7620

gtccttcctg ctttatctgc atcatccacc cacagagaaa tgcctctgtg cgagtgcacc     7680

gacagaaaac tgtcagctct gctttctaag gaaccctgag tgaggggggt attaagcttc     7740

tccagtgttt tttgttgtct ccaatcttaa acttaaattg agatctaaat tattaaacga     7800

gtttttgagc aaattaggtg acttgtttta aaaatattta attccgattt ggaaccttag     7860

atgtctattt gattttttaa aaaaccttaa tgtaagatat gaccagttaa aacaaagcaa     7920

ttcttgaatt atataactgt aaaagtgtgc agttaacaag gctggatgtg aattttattc     7980

tgagggtgat ttgtgatcaa gtttaatcac aaatctctta atatttataa actacctgat     8040

gccaggagct tagggctttg cattgtgtct aatacattga tcccagtgtt acgggattct     8100

cttgattcct ggcaccaaaa tcagattgtt ttcacagtta tgattcccag tgggagaaaa     8160

atgcctcaat atatttgtaa ccttaagaag agtatttttt tgttaatact aagatgttca     8220

aacttagaca tgattaggtc atacattctc aggggttcaa atttccttct accattcaaa     8280

tgttttatca acagcaaact tcagccgttt cactttttgt tggagaaaaa tagtagattt     8340

taatttgact cacagtttga agcattctgt gatcccctgg ttactgagtt aaaaaataaa     8400

aaagtacgag ttagacatat gaaatggtta tgaacgcttt tgtgctgctg atttttaatg     8460

ctgtaaagtt ttcctgtgtt tagcttgttg aaatgttttg catctgtcaa ttaaggaaaa     8520

aaaaaatcac tctatgttgc cccactttag agccctgtgt gccaccctgt gttcctgtga     8580

ttgcaatgtg agaccgaatg taatatggaa aacctaccag tggggtgtgg ttgtgccctg     8640

agcacgtgtg taaaggactg gggaggcgtg tcttgaaaaa gcaactgcag aaattcctta     8700

tgatgattgt gtgcaagtta gttaacatga accttcattt gtaaattttt taaaatttct     8760

tttataatat gctttccgca gtcctaacta tgctgcgttt tataatagct ttttcccttc     8820

tgttctgttc atgtagcaca gataagcatt gcacttggta ccatgcttta cctcatttca     8880

agaaaatatg cttaacagag aggaaaaaaa tgtggtttgg ccttgctgct gttttgattt     8940

atggaatttg aaaaagataa ttataatgcc tgcaatgtgt catatactcg cacaacttaa     9000

ataggtcatt tttgtctgtg gcatttttac tgtttgtgaa agtatgaaac agatttgtta     9060

actgaactct taattatgtt tttaaaatgt ttgttatatt tcttttcttt tttcttttat     9120

attacgtgaa gtgatgaaat ttagaatgac ctctaacact cctgtaattg tcttttaaaa     9180

tactgatatt tttatttgtt aataatactt tgccctcaga aagattctga taccctgcct     9240

tgacaacatg aaacttgagg ctgctttggt tcatgaatcc aggtgttccc ccggcagtcg     9300

gcttcttcag tcgctccctg gaggcaggtg ggcactgcag aggatcactg gaatccagat     9360

cgagcgcagt tcatgcacaa ggccccgttg atttaaaata ttggatcttg ctctgttagg     9420

gtgtctaatc cctttacaca agattgaagc caccaaactg agaccttgat accttttttt     9480

aactgcatct gaaattatgt taagagtctt taacccattt gcattatctg cagaagagaa     9540

actcatgtca tgtttattac ctatatggtt gttttaatta catttgaata attatatttt     9600

tccaaccact gattactttt caggaattta attatttcca gataaatttc tttattttat     9660

attgtacatg aaaagtttta aagatatgtt taagaccaag actattaaaa tgatttttaa     9720

agttgttgga gacgccaata gcaatatcta ggaaatttgc attgagacca ttgtattttc     9780

cactagcagt gaaaatgatt tttcacaact aacttgtaaa tatattttaa tcattacttc     9840

tttttttcta gtccattttt atttggacat caaccacaga caatttaaat tttatagatg     9900

cactaagaat tcactgcagc agcaggttac atagcaaaaa tgcaaaggtg aacaggaagt     9960

aaatttctgg cttttctgct gtaaatagtg aaggaaaatt actaaaatca agtaaaacta    10020

atgcatatta tttgattgac aataaaatat ttaccatcac atgctgcagc tgttttttaa    10080

ggaacatgat gtcattcatt catacagtaa tcatgctgca gaaatttgca gtctgcacct    10140

tatggatcac aattaccttt agttgttttt tttgtaataa ttgtagccaa gtaaatctcc    10200

aataaagtta tcgtctgttc                                                10220


<210>  9
<211>  1922
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Ser Pro Ala Leu Gln Pro Leu Ser Met Ala Gly Leu Gln Leu 
1               5                   10                  15      


Met Thr Pro Ala Ser Ser Pro Met Gly Pro Phe Phe Gly Leu Pro Trp 
            20                  25                  30          


Gln Gln Glu Ala Ile His Asp Asn Ile Tyr Thr Pro Arg Lys Tyr Gln 
        35                  40                  45              


Val Glu Leu Leu Glu Ala Ala Leu Asp His Asn Thr Ile Val Cys Leu 
    50                  55                  60                  


Asn Thr Gly Ser Gly Lys Thr Phe Ile Ala Val Leu Leu Thr Lys Glu 
65                  70                  75                  80  


Leu Ser Tyr Gln Ile Arg Gly Asp Phe Ser Arg Asn Gly Lys Arg Thr 
                85                  90                  95      


Val Phe Leu Val Asn Ser Ala Asn Gln Val Ala Gln Gln Val Ser Ala 
            100                 105                 110         


Val Arg Thr His Ser Asp Leu Lys Val Gly Glu Tyr Ser Asn Leu Glu 
        115                 120                 125             


Val Asn Ala Ser Trp Thr Lys Glu Arg Trp Asn Gln Glu Phe Thr Lys 
    130                 135                 140                 


His Gln Val Leu Ile Met Thr Cys Tyr Val Ala Leu Asn Val Leu Lys 
145                 150                 155                 160 


Asn Gly Tyr Leu Ser Leu Ser Asp Ile Asn Leu Leu Val Phe Asp Glu 
                165                 170                 175     


Cys His Leu Ala Ile Leu Asp His Pro Tyr Arg Glu Ile Met Lys Leu 
            180                 185                 190         


Cys Glu Asn Cys Pro Ser Cys Pro Arg Ile Leu Gly Leu Thr Ala Ser 
        195                 200                 205             


Ile Leu Asn Gly Lys Cys Asp Pro Glu Glu Leu Glu Glu Lys Ile Gln 
    210                 215                 220                 


Lys Leu Glu Lys Ile Leu Lys Ser Asn Ala Glu Thr Ala Thr Asp Leu 
225                 230                 235                 240 


Val Val Leu Asp Arg Tyr Thr Ser Gln Pro Cys Glu Ile Val Val Asp 
                245                 250                 255     


Cys Gly Pro Phe Thr Asp Arg Ser Gly Leu Tyr Glu Arg Leu Leu Met 
            260                 265                 270         


Glu Leu Glu Glu Ala Leu Asn Phe Ile Asn Asp Cys Asn Ile Ser Val 
        275                 280                 285             


His Ser Lys Glu Arg Asp Ser Thr Leu Ile Ser Lys Gln Ile Leu Ser 
    290                 295                 300                 


Asp Cys Arg Ala Val Leu Val Val Leu Gly Pro Trp Cys Ala Asp Lys 
305                 310                 315                 320 


Val Ala Gly Met Met Val Arg Glu Leu Gln Lys Tyr Ile Lys His Glu 
                325                 330                 335     


Gln Glu Glu Leu His Arg Lys Phe Leu Leu Phe Thr Asp Thr Phe Leu 
            340                 345                 350         


Arg Lys Ile His Ala Leu Cys Glu Glu His Phe Ser Pro Ala Ser Leu 
        355                 360                 365             


Asp Leu Lys Phe Val Thr Pro Lys Val Ile Lys Leu Leu Glu Ile Leu 
    370                 375                 380                 


Arg Lys Tyr Lys Pro Tyr Glu Arg Gln Gln Phe Glu Ser Val Glu Trp 
385                 390                 395                 400 


Tyr Asn Asn Arg Asn Gln Asp Asn Tyr Val Ser Trp Ser Asp Ser Glu 
                405                 410                 415     


Asp Asp Asp Glu Asp Glu Glu Ile Glu Glu Lys Glu Lys Pro Glu Thr 
            420                 425                 430         


Asn Phe Pro Ser Pro Phe Thr Asn Ile Leu Cys Gly Ile Ile Phe Val 
        435                 440                 445             


Glu Arg Arg Tyr Thr Ala Val Val Leu Asn Arg Leu Ile Lys Glu Ala 
    450                 455                 460                 


Gly Lys Gln Asp Pro Glu Leu Ala Tyr Ile Ser Ser Asn Phe Ile Thr 
465                 470                 475                 480 


Gly His Gly Ile Gly Lys Asn Gln Pro Arg Asn Lys Gln Met Glu Ala 
                485                 490                 495     


Glu Phe Arg Lys Gln Glu Glu Val Leu Arg Lys Phe Arg Ala His Glu 
            500                 505                 510         


Thr Asn Leu Leu Ile Ala Thr Ser Ile Val Glu Glu Gly Val Asp Ile 
        515                 520                 525             


Pro Lys Cys Asn Leu Val Val Arg Phe Asp Leu Pro Thr Glu Tyr Arg 
    530                 535                 540                 


Ser Tyr Val Gln Ser Lys Gly Arg Ala Arg Ala Pro Ile Ser Asn Tyr 
545                 550                 555                 560 


Ile Met Leu Ala Asp Thr Asp Lys Ile Lys Ser Phe Glu Glu Asp Leu 
                565                 570                 575     


Lys Thr Tyr Lys Ala Ile Glu Lys Ile Leu Arg Asn Lys Cys Ser Lys 
            580                 585                 590         


Ser Val Asp Thr Gly Glu Thr Asp Ile Asp Pro Val Met Asp Asp Asp 
        595                 600                 605             


Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp Gly Gly Pro Arg 
    610                 615                 620                 


Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg Tyr Cys Ala Arg 
625                 630                 635                 640 


Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys Cys Arg Thr Arg 
                645                 650                 655     


Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr Leu Pro Ile Asn 
            660                 665                 670         


Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met Ser Cys Val Arg 
        675                 680                 685             


Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu Lys Leu His Lys 
    690                 695                 700                 


Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly Lys Glu Thr Val 
705                 710                 715                 720 


Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu Glu Thr Ser Val 
                725                 730                 735     


Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys Tyr Pro Lys Ala 
            740                 745                 750         


Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro Asp Gln Pro Cys 
        755                 760                 765             


Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro Leu Pro Asp Glu 
    770                 775                 780                 


Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu Asp Thr Thr Arg 
785                 790                 795                 800 


Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln Ile Pro His Phe 
                805                 810                 815     


Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser Ile Glu Leu Lys 
            820                 825                 830         


Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu Leu Ile Thr Arg 
        835                 840                 845             


Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu Glu Lys Pro Ala 
    850                 855                 860                 


Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr Cys Val Leu Pro 
865                 870                 875                 880 


Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile Asp Phe Lys Phe 
                885                 890                 895     


Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly Ile Pro Ser Thr 
            900                 905                 910         


Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu Glu Asp Tyr Gln 
        915                 920                 925             


Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp Gln Pro His Arg 
    930                 935                 940                 


Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro Leu Ser Lys Phe 
945                 950                 955                 960 


Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr Lys Thr Lys Tyr 
                965                 970                 975     


Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu Asp Val Asp His 
            980                 985                 990         


Thr Ser Ser Arg Leu Asn Leu Leu  Thr Pro Arg His Leu  Asn Gln Lys 
        995                 1000                 1005             


Gly Lys  Ala Leu Pro Leu Ser  Ser Ala Glu Lys Arg  Lys Ala Lys 
    1010                 1015                 1020             


Trp Glu  Ser Leu Gln Asn Lys  Gln Ile Leu Val Pro  Glu Leu Cys 
    1025                 1030                 1035             


Ala Ile  His Pro Ile Pro Ala  Ser Leu Trp Arg Lys  Ala Val Cys 
    1040                 1045                 1050             


Leu Pro  Ser Ile Leu Tyr Arg  Leu His Cys Leu Leu  Thr Ala Glu 
    1055                 1060                 1065             


Glu Leu  Arg Ala Gln Thr Ala  Ser Asp Ala Gly Val  Gly Val Arg 
    1070                 1075                 1080             


Ser Leu  Pro Ala Asp Phe Arg  Tyr Pro Asn Leu Asp  Phe Gly Trp 
    1085                 1090                 1095             


Lys Lys  Ser Ile Asp Ser Lys  Ser Phe Ile Ser Ile  Ser Asn Ser 
    1100                 1105                 1110             


Ser Ser  Ala Glu Asn Asp Asn  Tyr Cys Lys His Ser  Thr Ile Val 
    1115                 1120                 1125             


Pro Glu  Asn Ala Ala His Gln  Gly Ala Asn Arg Thr  Ser Ser Leu 
    1130                 1135                 1140             


Glu Asn  His Asp Gln Met Ser  Val Asn Cys Arg Thr  Leu Leu Ser 
    1145                 1150                 1155             


Glu Ser  Pro Gly Lys Leu His  Val Glu Val Ser Ala  Asp Leu Thr 
    1160                 1165                 1170             


Ala Ile  Asn Gly Leu Ser Tyr  Asn Gln Asn Leu Ala  Asn Gly Ser 
    1175                 1180                 1185             


Tyr Asp  Leu Ala Asn Arg Asp  Phe Cys Gln Gly Asn  Gln Leu Asn 
    1190                 1195                 1200             


Tyr Tyr  Lys Gln Glu Ile Pro  Val Gln Pro Thr Thr  Ser Tyr Ser 
    1205                 1210                 1215             


Ile Gln  Asn Leu Tyr Ser Tyr  Glu Asn Gln Pro Gln  Pro Ser Asp 
    1220                 1225                 1230             


Glu Cys  Thr Leu Leu Ser Asn  Lys Tyr Leu Asp Gly  Asn Ala Asn 
    1235                 1240                 1245             


Lys Ser  Thr Ser Asp Gly Ser  Pro Val Met Ala Val  Met Pro Gly 
    1250                 1255                 1260             


Thr Thr  Asp Thr Ile Gln Val  Leu Lys Gly Arg Met  Asp Ser Glu 
    1265                 1270                 1275             


Gln Ser  Pro Ser Ile Gly Tyr  Ser Ser Arg Thr Leu  Gly Pro Asn 
    1280                 1285                 1290             


Pro Gly  Leu Ile Leu Gln Ala  Leu Thr Leu Ser Asn  Ala Ser Asp 
    1295                 1300                 1305             


Gly Phe  Asn Leu Glu Arg Leu  Glu Met Leu Gly Asp  Ser Phe Leu 
    1310                 1315                 1320             


Lys His  Ala Ile Thr Thr Tyr  Leu Phe Cys Thr Tyr  Pro Asp Ala 
    1325                 1330                 1335             


His Glu  Gly Arg Leu Ser Tyr  Met Arg Ser Lys Lys  Val Ser Asn 
    1340                 1345                 1350             


Cys Asn  Leu Tyr Arg Leu Gly  Lys Lys Lys Gly Leu  Pro Ser Arg 
    1355                 1360                 1365             


Met Val  Val Ser Ile Phe Asp  Pro Pro Val Asn Trp  Leu Pro Pro 
    1370                 1375                 1380             


Gly Tyr  Val Val Asn Gln Asp  Lys Ser Asn Thr Asp  Lys Trp Glu 
    1385                 1390                 1395             


Lys Asp  Glu Met Thr Lys Asp  Cys Met Leu Ala Asn  Gly Lys Leu 
    1400                 1405                 1410             


Asp Glu  Asp Tyr Glu Glu Glu  Asp Glu Glu Glu Glu  Ser Leu Met 
    1415                 1420                 1425             


Trp Arg  Ala Pro Lys Glu Glu  Ala Asp Tyr Glu Asp  Asp Phe Leu 
    1430                 1435                 1440             


Glu Tyr  Asp Gln Glu His Ile  Arg Phe Ile Asp Asn  Met Leu Met 
    1445                 1450                 1455             


Gly Ser  Gly Ala Phe Val Lys  Lys Ile Ser Leu Ser  Pro Phe Ser 
    1460                 1465                 1470             


Thr Thr  Asp Ser Ala Tyr Glu  Trp Lys Met Pro Lys  Lys Ser Ser 
    1475                 1480                 1485             


Leu Gly  Ser Met Pro Phe Ser  Ser Asp Phe Glu Asp  Phe Asp Tyr 
    1490                 1495                 1500             


Ser Ser  Trp Asp Ala Met Cys  Tyr Leu Asp Pro Ser  Lys Ala Val 
    1505                 1510                 1515             


Glu Glu  Asp Asp Phe Val Val  Gly Phe Trp Asn Pro  Ser Glu Glu 
    1520                 1525                 1530             


Asn Cys  Gly Val Asp Thr Gly  Lys Gln Ser Ile Ser  Tyr Asp Leu 
    1535                 1540                 1545             


His Thr  Glu Gln Cys Ile Ala  Asp Lys Ser Ile Ala  Asp Cys Val 
    1550                 1555                 1560             


Glu Ala  Leu Leu Gly Cys Tyr  Leu Thr Ser Cys Gly  Glu Arg Ala 
    1565                 1570                 1575             


Ala Gln  Leu Phe Leu Cys Ser  Leu Gly Leu Lys Val  Leu Pro Val 
    1580                 1585                 1590             


Ile Lys  Arg Thr Asp Arg Glu  Lys Ala Leu Cys Pro  Thr Arg Glu 
    1595                 1600                 1605             


Asn Phe  Asn Ser Gln Gln Lys  Asn Leu Ser Val Ser  Cys Ala Ala 
    1610                 1615                 1620             


Ala Ser  Val Ala Ser Ser Arg  Ser Ser Val Leu Lys  Asp Ser Glu 
    1625                 1630                 1635             


Tyr Gly  Cys Leu Lys Ile Pro  Pro Arg Cys Met Phe  Asp His Pro 
    1640                 1645                 1650             


Asp Ala  Asp Lys Thr Leu Asn  His Leu Ile Ser Gly  Phe Glu Asn 
    1655                 1660                 1665             


Phe Glu  Lys Lys Ile Asn Tyr  Arg Phe Lys Asn Lys  Ala Tyr Leu 
    1670                 1675                 1680             


Leu Gln  Ala Phe Thr His Ala  Ser Tyr His Tyr Asn  Thr Ile Thr 
    1685                 1690                 1695             


Asp Cys  Tyr Gln Arg Leu Glu  Phe Leu Gly Asp Ala  Ile Leu Asp 
    1700                 1705                 1710             


Tyr Leu  Ile Thr Lys His Leu  Tyr Glu Asp Pro Arg  Gln His Ser 
    1715                 1720                 1725             


Pro Gly  Val Leu Thr Asp Leu  Arg Ser Ala Leu Val  Asn Asn Thr 
    1730                 1735                 1740             


Ile Phe  Ala Ser Leu Ala Val  Lys Tyr Asp Tyr His  Lys Tyr Phe 
    1745                 1750                 1755             


Lys Ala  Val Ser Pro Glu Leu  Phe His Val Ile Asp  Asp Phe Val 
    1760                 1765                 1770             


Gln Phe  Gln Leu Glu Lys Asn  Glu Met Gln Gly Met  Asp Ser Glu 
    1775                 1780                 1785             


Leu Arg  Arg Ser Glu Glu Asp  Glu Glu Lys Glu Glu  Asp Ile Glu 
    1790                 1795                 1800             


Val Pro  Lys Ala Met Gly Asp  Ile Phe Glu Ser Leu  Ala Gly Ala 
    1805                 1810                 1815             


Ile Tyr  Met Asp Ser Gly Met  Ser Leu Glu Thr Val  Trp Gln Val 
    1820                 1825                 1830             


Tyr Tyr  Pro Met Met Arg Pro  Leu Ile Glu Lys Phe  Ser Ala Asn 
    1835                 1840                 1845             


Val Pro  Arg Ser Pro Val Arg  Glu Leu Leu Glu Met  Glu Pro Glu 
    1850                 1855                 1860             


Thr Ala  Lys Phe Ser Pro Ala  Glu Arg Thr Tyr Asp  Gly Lys Val 
    1865                 1870                 1875             


Arg Val  Thr Val Glu Val Val  Gly Lys Gly Lys Phe  Lys Gly Val 
    1880                 1885                 1890             


Gly Arg  Ser Tyr Arg Ile Ala  Lys Ser Ala Ala Ala  Arg Arg Ala 
    1895                 1900                 1905             


Leu Arg  Ser Leu Lys Ala Asn  Gln Pro Gln Val Pro  Asn Ser 
    1910                 1915                 1920         


<210>  10
<211>  647
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ser Glu Gln Ser Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly 
1               5                   10                  15      


Pro Asn Pro Gly Leu Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser 
            20                  25                  30          


Asp Gly Phe Asn Leu Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu 
        35                  40                  45              


Lys His Ala Ile Thr Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His 
    50                  55                  60                  


Glu Gly Arg Leu Ser Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn 
65                  70                  75                  80  


Leu Tyr Arg Leu Gly Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val 
                85                  90                  95      


Ser Ile Phe Asp Pro Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val 
            100                 105                 110         


Asn Gln Asp Lys Ser Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr 
        115                 120                 125             


Lys Asp Cys Met Leu Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu 
    130                 135                 140                 


Glu Asp Glu Glu Glu Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu 
145                 150                 155                 160 


Ala Asp Tyr Glu Asp Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg 
                165                 170                 175     


Phe Ile Asp Asn Met Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile 
            180                 185                 190         


Ser Leu Ser Pro Phe Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met 
        195                 200                 205             


Pro Lys Lys Ser Ser Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu 
    210                 215                 220                 


Asp Phe Asp Tyr Ser Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser 
225                 230                 235                 240 


Lys Ala Val Glu Glu Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser 
                245                 250                 255     


Glu Glu Asn Cys Gly Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp 
            260                 265                 270         


Leu His Thr Glu Gln Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val 
        275                 280                 285             


Glu Ala Leu Leu Gly Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala 
    290                 295                 300                 


Gln Leu Phe Leu Cys Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys 
305                 310                 315                 320 


Arg Thr Asp Arg Glu Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe Asn 
                325                 330                 335     


Ser Gln Gln Lys Asn Leu Ser Val Ser Cys Ala Ala Ala Ser Val Ala 
            340                 345                 350         


Ser Ser Arg Ser Ser Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu Lys 
        355                 360                 365             


Ile Pro Pro Arg Cys Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu 
    370                 375                 380                 


Asn His Leu Ile Ser Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr 
385                 390                 395                 400 


Arg Phe Lys Asn Lys Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser 
                405                 410                 415     


Tyr His Tyr Asn Thr Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu 
            420                 425                 430         


Gly Asp Ala Ile Leu Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp 
        435                 440                 445             


Pro Arg Gln His Ser Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu 
    450                 455                 460                 


Val Asn Asn Thr Ile Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His 
465                 470                 475                 480 


Lys Tyr Phe Lys Ala Val Ser Pro Glu Leu Phe His Val Ile Asp Asp 
                485                 490                 495     


Phe Val Gln Phe Gln Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser 
            500                 505                 510         


Glu Leu Arg Arg Ser Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu 
        515                 520                 525             


Val Pro Lys Ala Met Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile 
    530                 535                 540                 


Tyr Met Asp Ser Gly Met Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr 
545                 550                 555                 560 


Pro Met Met Arg Pro Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg 
                565                 570                 575     


Ser Pro Val Arg Glu Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe 
            580                 585                 590         


Ser Pro Ala Glu Arg Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu 
        595                 600                 605             


Val Val Gly Lys Gly Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile 
    610                 615                 620                 


Ala Lys Ser Ala Ala Ala Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn 
625                 630                 635                 640 


Gln Pro Gln Val Pro Asn Ser 
                645         


<210>  11
<211>  1318
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Asp Asp Asp Val Phe Pro Pro Tyr Val Leu Arg Pro Asp Asp 
1               5                   10                  15      


Gly Gly Pro Arg Val Thr Ile Asn Thr Ala Ile Gly His Ile Asn Arg 
            20                  25                  30          


Tyr Cys Ala Arg Leu Pro Ser Asp Pro Phe Thr His Leu Ala Pro Lys 
        35                  40                  45              


Cys Arg Thr Arg Glu Leu Pro Asp Gly Thr Phe Tyr Ser Thr Leu Tyr 
    50                  55                  60                  


Leu Pro Ile Asn Ser Pro Leu Arg Ala Ser Ile Val Gly Pro Pro Met 
65                  70                  75                  80  


Ser Cys Val Arg Leu Ala Glu Arg Val Val Ala Leu Ile Cys Cys Glu 
                85                  90                  95      


Lys Leu His Lys Ile Gly Glu Leu Asp Asp His Leu Met Pro Val Gly 
            100                 105                 110         


Lys Glu Thr Val Lys Tyr Glu Glu Glu Leu Asp Leu His Asp Glu Glu 
        115                 120                 125             


Glu Thr Ser Val Pro Gly Arg Pro Gly Ser Thr Lys Arg Arg Gln Cys 
    130                 135                 140                 


Tyr Pro Lys Ala Ile Pro Glu Cys Leu Arg Asp Ser Tyr Pro Arg Pro 
145                 150                 155                 160 


Asp Gln Pro Cys Tyr Leu Tyr Val Ile Gly Met Val Leu Thr Thr Pro 
                165                 170                 175     


Leu Pro Asp Glu Leu Asn Phe Arg Arg Arg Lys Leu Tyr Pro Pro Glu 
            180                 185                 190         


Asp Thr Thr Arg Cys Phe Gly Ile Leu Thr Ala Lys Pro Ile Pro Gln 
        195                 200                 205             


Ile Pro His Phe Pro Val Tyr Thr Arg Ser Gly Glu Val Thr Ile Ser 
    210                 215                 220                 


Ile Glu Leu Lys Lys Ser Gly Phe Met Leu Ser Leu Gln Met Leu Glu 
225                 230                 235                 240 


Leu Ile Thr Arg Leu His Gln Tyr Ile Phe Ser His Ile Leu Arg Leu 
                245                 250                 255     


Glu Lys Pro Ala Leu Glu Phe Lys Pro Thr Asp Ala Asp Ser Ala Tyr 
            260                 265                 270         


Cys Val Leu Pro Leu Asn Val Val Asn Asp Ser Ser Thr Leu Asp Ile 
        275                 280                 285             


Asp Phe Lys Phe Met Glu Asp Ile Glu Lys Ser Glu Ala Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ser Thr Lys Tyr Thr Lys Glu Thr Pro Phe Val Phe Lys Leu 
305                 310                 315                 320 


Glu Asp Tyr Gln Asp Ala Val Ile Ile Pro Arg Tyr Arg Asn Phe Asp 
                325                 330                 335     


Gln Pro His Arg Phe Tyr Val Ala Asp Val Tyr Thr Asp Leu Thr Pro 
            340                 345                 350         


Leu Ser Lys Phe Pro Ser Pro Glu Tyr Glu Thr Phe Ala Glu Tyr Tyr 
        355                 360                 365             


Lys Thr Lys Tyr Asn Leu Asp Leu Thr Asn Leu Asn Gln Pro Leu Leu 
    370                 375                 380                 


Asp Val Asp His Thr Ser Ser Arg Leu Asn Leu Leu Thr Pro Arg His 
385                 390                 395                 400 


Leu Asn Gln Lys Gly Lys Ala Leu Pro Leu Ser Ser Ala Glu Lys Arg 
                405                 410                 415     


Lys Ala Lys Trp Glu Ser Leu Gln Asn Lys Gln Ile Leu Val Pro Glu 
            420                 425                 430         


Leu Cys Ala Ile His Pro Ile Pro Ala Ser Leu Trp Arg Lys Ala Val 
        435                 440                 445             


Cys Leu Pro Ser Ile Leu Tyr Arg Leu His Cys Leu Leu Thr Ala Glu 
    450                 455                 460                 


Glu Leu Arg Ala Gln Thr Ala Ser Asp Ala Gly Val Gly Val Arg Ser 
465                 470                 475                 480 


Leu Pro Ala Asp Phe Arg Tyr Pro Asn Leu Asp Phe Gly Trp Lys Lys 
                485                 490                 495     


Ser Ile Asp Ser Lys Ser Phe Ile Ser Ile Ser Asn Ser Ser Ser Ala 
            500                 505                 510         


Glu Asn Asp Asn Tyr Cys Lys His Ser Thr Ile Val Pro Glu Asn Ala 
        515                 520                 525             


Ala His Gln Gly Ala Asn Arg Thr Ser Ser Leu Glu Asn His Asp Gln 
    530                 535                 540                 


Met Ser Val Asn Cys Arg Thr Leu Leu Ser Glu Ser Pro Gly Lys Leu 
545                 550                 555                 560 


His Val Glu Val Ser Ala Asp Leu Thr Ala Ile Asn Gly Leu Ser Tyr 
                565                 570                 575     


Asn Gln Asn Leu Ala Asn Gly Ser Tyr Asp Leu Ala Asn Arg Asp Phe 
            580                 585                 590         


Cys Gln Gly Asn Gln Leu Asn Tyr Tyr Lys Gln Glu Ile Pro Val Gln 
        595                 600                 605             


Pro Thr Thr Ser Tyr Ser Ile Gln Asn Leu Tyr Ser Tyr Glu Asn Gln 
    610                 615                 620                 


Pro Gln Pro Ser Asp Glu Cys Thr Leu Leu Ser Asn Lys Tyr Leu Asp 
625                 630                 635                 640 


Gly Asn Ala Asn Lys Ser Thr Ser Asp Gly Ser Pro Val Met Ala Val 
                645                 650                 655     


Met Pro Gly Thr Thr Asp Thr Ile Gln Val Leu Lys Gly Arg Met Asp 
            660                 665                 670         


Ser Glu Gln Ser Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly Pro 
        675                 680                 685             


Asn Pro Gly Leu Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser Asp 
    690                 695                 700                 


Gly Phe Asn Leu Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu Lys 
705                 710                 715                 720 


His Ala Ile Thr Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His Glu 
                725                 730                 735     


Gly Arg Leu Ser Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn Leu 
            740                 745                 750         


Tyr Arg Leu Gly Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val Ser 
        755                 760                 765             


Ile Phe Asp Pro Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val Asn 
    770                 775                 780                 


Gln Asp Lys Ser Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr Lys 
785                 790                 795                 800 


Asp Cys Met Leu Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu Glu 
                805                 810                 815     


Asp Glu Glu Glu Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu Ala 
            820                 825                 830         


Asp Tyr Glu Asp Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg Phe 
        835                 840                 845             


Ile Asp Asn Met Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile Ser 
    850                 855                 860                 


Leu Ser Pro Phe Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met Pro 
865                 870                 875                 880 


Lys Lys Ser Ser Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu Asp 
                885                 890                 895     


Phe Asp Tyr Ser Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser Lys 
            900                 905                 910         


Ala Val Glu Glu Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser Glu 
        915                 920                 925             


Glu Asn Cys Gly Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp Leu 
    930                 935                 940                 


His Thr Glu Gln Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val Glu 
945                 950                 955                 960 


Ala Leu Leu Gly Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala Gln 
                965                 970                 975     


Leu Phe Leu Cys Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys Arg 
            980                 985                 990         


Thr Asp Arg Glu Lys Ala Leu Cys  Pro Thr Arg Glu Asn  Phe Asn Ser 
        995                 1000                 1005             


Gln Gln  Lys Asn Leu Ser Val  Ser Cys Ala Ala Ala  Ser Val Ala 
    1010                 1015                 1020             


Ser Ser  Arg Ser Ser Val Leu  Lys Asp Ser Glu Tyr  Gly Cys Leu 
    1025                 1030                 1035             


Lys Ile  Pro Pro Arg Cys Met  Phe Asp His Pro Asp  Ala Asp Lys 
    1040                 1045                 1050             


Thr Leu  Asn His Leu Ile Ser  Gly Phe Glu Asn Phe  Glu Lys Lys 
    1055                 1060                 1065             


Ile Asn  Tyr Arg Phe Lys Asn  Lys Ala Tyr Leu Leu  Gln Ala Phe 
    1070                 1075                 1080             


Thr His  Ala Ser Tyr His Tyr  Asn Thr Ile Thr Asp  Cys Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Glu Phe Leu Gly Asp  Ala Ile Leu Asp Tyr  Leu Ile Thr 
    1100                 1105                 1110             


Lys His  Leu Tyr Glu Asp Pro  Arg Gln His Ser Pro  Gly Val Leu 
    1115                 1120                 1125             


Thr Asp  Leu Arg Ser Ala Leu  Val Asn Asn Thr Ile  Phe Ala Ser 
    1130                 1135                 1140             


Leu Ala  Val Lys Tyr Asp Tyr  His Lys Tyr Phe Lys  Ala Val Ser 
    1145                 1150                 1155             


Pro Glu  Leu Phe His Val Ile  Asp Asp Phe Val Gln  Phe Gln Leu 
    1160                 1165                 1170             


Glu Lys  Asn Glu Met Gln Gly  Met Asp Ser Glu Leu  Arg Arg Ser 
    1175                 1180                 1185             


Glu Glu  Asp Glu Glu Lys Glu  Glu Asp Ile Glu Val  Pro Lys Ala 
    1190                 1195                 1200             


Met Gly  Asp Ile Phe Glu Ser  Leu Ala Gly Ala Ile  Tyr Met Asp 
    1205                 1210                 1215             


Ser Gly  Met Ser Leu Glu Thr  Val Trp Gln Val Tyr  Tyr Pro Met 
    1220                 1225                 1230             


Met Arg  Pro Leu Ile Glu Lys  Phe Ser Ala Asn Val  Pro Arg Ser 
    1235                 1240                 1245             


Pro Val  Arg Glu Leu Leu Glu  Met Glu Pro Glu Thr  Ala Lys Phe 
    1250                 1255                 1260             


Ser Pro  Ala Glu Arg Thr Tyr  Asp Gly Lys Val Arg  Val Thr Val 
    1265                 1270                 1275             


Glu Val  Val Gly Lys Gly Lys  Phe Lys Gly Val Gly  Arg Ser Tyr 
    1280                 1285                 1290             


Arg Ile  Ala Lys Ser Ala Ala  Ala Arg Arg Ala Leu  Arg Ser Leu 
    1295                 1300                 1305             


Lys Ala  Asn Gln Pro Gln Val  Pro Asn Ser 
    1310                 1315             


<210>  12
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  12

Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys Ala 
1               5                   10                  15      


Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr Ile 
            20                  25                  30          


Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu Asp 
        35                  40                  45              


Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser Pro 
    50                  55                  60                  


Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile Phe 
65                  70                  75                  80  


Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala Val 
                85                  90                  95      


Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln Leu 
            100                 105                 110         


Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg Ser Glu 
        115                 120                 125             


Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala Met Gly 
    130                 135                 140                 


Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly Met 
145                 150                 155                 160 


Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro Met Met Arg Pro Leu 
                165                 170                 175     


Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg Glu Leu 
            180                 185                 190         


Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg Thr 
        195                 200                 205             


Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly Lys Gly Lys 
    210                 215                 220                 


Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala Ala 
225                 230                 235                 240 


Arg Arg Ala Leu Arg Ser Leu Lys Ala Asn Gln Pro Gln Val Pro Asn 
                245                 250                 255     


Ser 
    


<210>  13
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  13

Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys Ala 
1               5                   10                  15      


Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr Ile 
            20                  25                  30          


Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu Asp 
        35                  40                  45              


Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser Pro 
    50                  55                  60                  


Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile Phe 
65                  70                  75                  80  


Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala Val 
                85                  90                  95      


Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln Leu 
            100                 105                 110         


Glu Lys Asn Glu Met Gln Gly Met Asp Ser Glu Leu Arg Arg Ser Glu 
        115                 120                 125             


Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu Val Pro Lys Ala Met Gly 
    130                 135                 140                 


Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp Ser Gly Met 
145                 150                 155                 160 


Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro Met Met Arg Pro Leu 
                165                 170                 175     


Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val Arg Glu Leu 
            180                 185                 190         


Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala Glu Arg Thr 
        195                 200                 205             


Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly Lys Gly Lys 
    210                 215                 220                 


Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser Ala Ala Ala 
225                 230                 235                 240 


Arg Arg Ala Leu Arg Ser Leu 
                245         


<210>  14
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  14

Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr Arg Phe Lys Asn Lys Ala 
1               5                   10                  15      


Tyr Leu Leu Gln Ala Phe Thr His Ala Ser Tyr His Tyr Asn Thr Ile 
            20                  25                  30          


Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu Gly Asp Ala Ile Leu Asp 
        35                  40                  45              


Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp Pro Arg Gln His Ser Pro 
    50                  55                  60                  


Gly Val Leu Thr Asp Leu Arg Ser Ala Leu Val Asn Asn Thr Ile Phe 
65                  70                  75                  80  


Ala Ser Leu Ala Val Lys Tyr Asp Tyr His Lys Tyr Phe Lys Ala Val 
                85                  90                  95      


Ser Pro Glu Leu Phe His Val Ile Asp Asp Phe Val Gln Phe Gln Leu 
            100                 105                 110         


Glu Lys Asn Glu Met Gln Gly Met Asp Glu Asp Ile Glu Val Pro Lys 
        115                 120                 125             


Ala Met Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile Tyr Met Asp 
    130                 135                 140                 


Ser Gly Met Ser Leu Glu Thr Val Trp Gln Val Tyr Tyr Pro Met Met 
145                 150                 155                 160 


Arg Pro Leu Ile Glu Lys Phe Ser Ala Asn Val Pro Arg Ser Pro Val 
                165                 170                 175     


Arg Glu Leu Leu Glu Met Glu Pro Glu Thr Ala Lys Phe Ser Pro Ala 
            180                 185                 190         


Glu Arg Thr Tyr Asp Gly Lys Val Arg Val Thr Val Glu Val Val Gly 
        195                 200                 205             


Lys Gly Lys Phe Lys Gly Val Gly Arg Ser Tyr Arg Ile Ala Lys Ser 
    210                 215                 220                 


Ala Ala Ala Arg Arg Ala Leu Arg Ser Leu 
225                 230                 


<210>  15
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Ser Glu Gln Ser Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu 
1               5                   10                  15      


Gly Pro Asn Pro Gly Leu Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala 
            20                  25                  30          


Ser Asp Gly Phe Asn Leu Glu Arg Leu Glu Met Leu Gly Asp Ser Phe 
        35                  40                  45              


Leu Lys His Ala Ile Thr Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala 
    50                  55                  60                  


His Glu Gly Arg Leu Ser Tyr Met Arg Ser Lys Lys Val Ser Asn Cys 
65                  70                  75                  80  


Asn Leu Tyr Arg Leu Gly Lys Lys Lys Gly Leu Pro Ser Arg Met Val 
                85                  90                  95      


Val Ser Ile Phe Asp Pro Pro Val Asn Trp Leu Pro Pro Gly Tyr Val 
            100                 105                 110         


Val Asn Gln Asp Lys Ser Asn Thr Asp Lys Trp Glu Lys Asp Glu Met 
        115                 120                 125             


Thr Lys Asp Cys Met Leu Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu 
    130                 135                 140                 


Glu Glu Asp Glu Glu Glu Glu Ser Leu Met Trp Arg Ala Pro Lys Glu 
145                 150                 155                 160 


Glu Ala Asp Tyr Glu Asp Asp Phe Leu Glu Tyr Asp Gln Glu His Ile 
                165                 170                 175     


Arg Phe Ile Asp Asn Met Leu Met Gly Ser Gly Ala Phe Val Lys Lys 
            180                 185                 190         


Ile Ser Leu Ser Pro Phe Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys 
        195                 200                 205             


Met Pro Lys Lys Ser Ser Leu Gly Ser Met Pro Phe Ser Ser Asp Phe 
    210                 215                 220                 


Glu Asp Phe Asp Tyr Ser Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro 
225                 230                 235                 240 


Ser Lys Ala Val Glu Glu Asp Asp Phe Val Val Gly Phe Trp Asn Pro 
                245                 250                 255     


Ser Glu Glu Asn Cys Gly Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr 
            260                 265                 270         


Asp Leu His Thr Glu Gln Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys 
        275                 280                 285             


Val Glu Ala Leu Leu Gly Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala 
    290                 295                 300                 


Ala Gln Leu Phe Leu Cys Ser Leu Gly Leu Lys Val Leu Pro Val Ile 
305                 310                 315                 320 


Lys Arg Thr Asp Arg Glu Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe 
                325                 330                 335     


Asn Ser Gln Gln Lys Asn Leu Ser Val Ser Cys Ala Ala Ala Ser Val 
            340                 345                 350         


Ala Ser Ser Arg Ser Ser Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu 
        355                 360                 365             


Lys Ile Pro Pro Arg Cys Met Phe Asp His Pro Asp Ala Asp Lys Thr 
    370                 375                 380                 


Leu Asn His Leu Ile Ser Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn 
385                 390                 395                 400 


Tyr Arg Phe Lys Asn Lys Ala Tyr Leu Leu Gln Ala Phe Thr His Ala 
                405                 410                 415     


Ser Tyr His Tyr Asn Thr Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe 
            420                 425                 430         


Leu Gly Asp Ala Ile Leu Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu 
        435                 440                 445             


Asp Pro Arg Gln His Ser Pro Gly Val Leu Thr Asp Leu Arg Ser Ala 
    450                 455                 460                 


Leu Val Asn Asn Thr Ile Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr 
465                 470                 475                 480 


His Lys Tyr Phe Lys Ala Val Ser Pro Glu Leu Phe His Val Ile Asp 
                485                 490                 495     


Asp Phe Val Gln Phe Gln Leu Glu Lys Asn Glu Met Gln Gly Met Asp 
            500                 505                 510         


Ser Glu Leu Arg Arg Ser Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile 
        515                 520                 525             


Glu Val Pro Lys Ala Met Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala 
    530                 535                 540                 


Ile Tyr Met Asp Ser Gly 
545                 550 


<210>  16
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  16

Asp Ser Glu Gln Ser Pro Ser Ile Gly Tyr Ser Ser Arg Thr Leu Gly 
1               5                   10                  15      


Pro Asn Pro Gly Leu Ile Leu Gln Ala Leu Thr Leu Ser Asn Ala Ser 
            20                  25                  30          


Asp Gly Phe Asn Leu Glu Arg Leu Glu Met Leu Gly Asp Ser Phe Leu 
        35                  40                  45              


Lys His Ala Ile Thr Thr Tyr Leu Phe Cys Thr Tyr Pro Asp Ala His 
    50                  55                  60                  


Glu Gly Arg Leu Ser Tyr Met Arg Ser Lys Lys Val Ser Asn Cys Asn 
65                  70                  75                  80  


Leu Tyr Arg Leu Gly Lys Lys Lys Gly Leu Pro Ser Arg Met Val Val 
                85                  90                  95      


Ser Ile Phe Asp Pro Pro Val Asn Trp Leu Pro Pro Gly Tyr Val Val 
            100                 105                 110         


Asn Gln Asp Lys Ser Asn Thr Asp Lys Trp Glu Lys Asp Glu Met Thr 
        115                 120                 125             


Lys Asp Cys Met Leu Ala Asn Gly Lys Leu Asp Glu Asp Tyr Glu Glu 
    130                 135                 140                 


Glu Asp Glu Glu Glu Glu Ser Leu Met Trp Arg Ala Pro Lys Glu Glu 
145                 150                 155                 160 


Ala Asp Tyr Glu Asp Asp Phe Leu Glu Tyr Asp Gln Glu His Ile Arg 
                165                 170                 175     


Phe Ile Asp Asn Met Leu Met Gly Ser Gly Ala Phe Val Lys Lys Ile 
            180                 185                 190         


Ser Leu Ser Pro Phe Ser Thr Thr Asp Ser Ala Tyr Glu Trp Lys Met 
        195                 200                 205             


Pro Lys Lys Ser Ser Leu Gly Ser Met Pro Phe Ser Ser Asp Phe Glu 
    210                 215                 220                 


Asp Phe Asp Tyr Ser Ser Trp Asp Ala Met Cys Tyr Leu Asp Pro Ser 
225                 230                 235                 240 


Lys Ala Val Glu Glu Asp Asp Phe Val Val Gly Phe Trp Asn Pro Ser 
                245                 250                 255     


Glu Glu Asn Cys Gly Val Asp Thr Gly Lys Gln Ser Ile Ser Tyr Asp 
            260                 265                 270         


Leu His Thr Glu Gln Cys Ile Ala Asp Lys Ser Ile Ala Asp Cys Val 
        275                 280                 285             


Glu Ala Leu Leu Gly Cys Tyr Leu Thr Ser Cys Gly Glu Arg Ala Ala 
    290                 295                 300                 


Gln Leu Phe Leu Cys Ser Leu Gly Leu Lys Val Leu Pro Val Ile Lys 
305                 310                 315                 320 


Arg Thr Asp Arg Glu Lys Ala Leu Cys Pro Thr Arg Glu Asn Phe Asn 
                325                 330                 335     


Ser Gln Gln Lys Asn Leu Ser Val Ser Cys Ala Ala Ala Ser Val Ala 
            340                 345                 350         


Ser Ser Arg Ser Ser Val Leu Lys Asp Ser Glu Tyr Gly Cys Leu Lys 
        355                 360                 365             


Ile Pro Pro Arg Cys Met Phe Asp His Pro Asp Ala Asp Lys Thr Leu 
    370                 375                 380                 


Asn His Leu Ile Ser Gly Phe Glu Asn Phe Glu Lys Lys Ile Asn Tyr 
385                 390                 395                 400 


Arg Phe Lys Asn Lys Ala Tyr Leu Leu Gln Ala Phe Thr His Ala Ser 
                405                 410                 415     


Tyr His Tyr Asn Thr Ile Thr Asp Cys Tyr Gln Arg Leu Glu Phe Leu 
            420                 425                 430         


Gly Asp Ala Ile Leu Asp Tyr Leu Ile Thr Lys His Leu Tyr Glu Asp 
        435                 440                 445             


Pro Arg Gln His Ser Pro Gly Val Leu Thr Asp Leu Arg Ser Ala Leu 
    450                 455                 460                 


Val Asn Asn Thr Ile Phe Ala Ser Leu Ala Val Lys Tyr Asp Tyr His 
465                 470                 475                 480 


Lys Tyr Phe Lys Ala Val Ser Pro Glu Leu Phe His Val Ile Asp Asp 
                485                 490                 495     


Phe Val Gln Phe Gln Leu Glu Lys Asn Glu Met Gln Gly Met Asp Ser 
            500                 505                 510         


Glu Leu Arg Arg Ser Glu Glu Asp Glu Glu Lys Glu Glu Asp Ile Glu 
        515                 520                 525             


Val Pro Lys Ala Met Gly Asp Ile Phe Glu Ser Leu Ala Gly Ala Ile 
    530                 535                 540                 


Tyr Met Asp Ser Gly 
545                 


<210>  17
<211>  10323
<212>  DNA
<213>  Homo sapiens

<400>  17
cggaggcgcg gcgcaggctg ctgcaggccc aggtgaatgg agtaacctga cagcggggac       60

gaggcgacgg cgagcgcgag gaaatggcgg cgggggcggc ggcgccgggc ggctccggga      120

ggcctgggct gtgacgcgcg cgccggagcg gggtccgatg gttctcgaag gcccgcggcg      180

ccccgtgctg cagtaagctg tgctagaaca aaaatgcaat gaaagaaaca ctggatgaat      240

gaaaagccct gctttgcaac ccctcagcat ggcaggcctg cagctcatga cccctgcttc      300

ctcaccaatg ggtcctttct ttggactgcc atggcaacaa gaagcaattc atgataacat      360

ttatacgcca agaaaatatc aggttgaact gcttgaagca gctctggatc ataataccat      420

cgtctgttta aacactggct cagggaagac atttattgca gtactactca ctaaagagct      480

gtcctatcag atcaggggag acttcagcag aaatggaaaa aggacggtgt tcttggtcaa      540

ctctgcaaac caggttgctc aacaagtgtc agctgtcaga actcattcag atctcaaggt      600

tggggaatac tcaaacctag aagtaaatgc atcttggaca aaagagagat ggaaccaaga      660

gtttactaag caccaggttc tcattatgac ttgctatgtc gccttgaatg ttttgaaaaa      720

tggttactta tcactgtcag acattaacct tttggtgttt gatgagtgtc atcttgcaat      780

cctagaccac ccctatcgag aaattatgaa gctctgtgaa aattgtccat catgtcctcg      840

cattttggga ctaactgctt ccattttaaa tgggaaatgt gatccagagg aattggaaga      900

aaagattcag aaactagaga aaattcttaa gagtaatgct gaaactgcaa ctgacctggt      960

ggtcttagac aggtatactt ctcagccatg tgagattgtg gtggattgtg gaccatttac     1020

tgacagaagt gggctttatg aaagactgct gatggaatta gaagaagcac ttaattttat     1080

caatgattgt aatatatctg tacattcaaa agaaagagat tctactttaa tttcgaaaca     1140

gatactatca gactgtcgtg ccgtattggt agttctggga ccctggtgtg cagataaagt     1200

agctggaatg atggtaagag aactacagaa atacatcaaa catgagcaag aggagctgca     1260

caggaaattt ttattgttta cagacacttt cctaaggaaa atacatgcac tatgtgaaga     1320

gcacttctca cctgcctcac ttgacctgaa atttgtaact cctaaagtaa tcaaactgct     1380

cgaaatctta cgcaaatata aaccatatga gcgacagcag tttgaaagcg ttgagtggta     1440

taataataga aatcaggata attatgtgtc atggagtgat tctgaggatg atgatgagga     1500

tgaagaaatt gaagaaaaag agaagccaga gacaaatttt ccttctcctt ttaccaacat     1560

tttgtgcgga attatttttg tggaaagaag atacacagca gttgtcttaa acagattgat     1620

aaaggaagct ggcaaacaag atccagagct ggcttatatc agtagcaatt tcataactgg     1680

acatggcatt gggaagaatc agcctcgcaa caaacagatg gaagcagaat tcagaaaaca     1740

ggaagaggta cttaggaaat ttcgagcaca tgagaccaac ctgcttattg caacaagtat     1800

tgtagaagag ggtgttgata taccaaaatg caacttggtg gttcgttttg atttgcccac     1860

agaatatcga tcctatgttc aatctaaagg aagagcaagg gcacccatct ctaattatat     1920

aatgttagcg gatacagaca aaataaaaag ttttgaagaa gaccttaaaa cctacaaagc     1980

tattgaaaag atcttgagaa acaagtgttc caagtcggtt gatactggtg agactgacat     2040

tgatcctgtc atggatgatg atgacgtttt cccaccatat gtgttgaggc ctgacgatgg     2100

tggtccacga gtcacaatca acacggccat tggacacatc aatagatact gtgctagatt     2160

accaagtgat ccgtttactc atctagctcc taaatgcaga acccgagagt tgcctgatgg     2220

tacattttat tcaactcttt atctgccaat taactcacct cttcgagcct ccattgttgg     2280

tccaccaatg agctgtgtac gattggctga aagagttgta gctctcattt gctgtgagaa     2340

actgcacaaa attggcgaac tggatgacca tttgatgcca gttgggaaag agactgttaa     2400

atatgaagag gagcttgatt tgcatgatga agaagagacc agtgttccag gaagaccagg     2460

ttccacgaaa cgaaggcagt gctacccaaa agcaattcca gagtgtttga gggatagtta     2520

tcccagacct gatcagccct gttacctgta tgtgatagga atggttttaa ctacaccttt     2580

acctgatgaa ctcaacttta gaaggcggaa gctctatcct cctgaagata ccacaagatg     2640

ctttggaata ctgacggcca aacccatacc tcagattcca cactttcctg tgtacacacg     2700

ctctggagag gttaccatat ccattgagtt gaagaagtct ggtttcatgt tgtctctaca     2760

aatgcttgag ttgattacaa gacttcacca gtatatattc tcacatattc ttcggcttga     2820

aaaacctgca ctagaattta aacctacaga cgctgattca gcatactgtg ttctacctct     2880

taatgttgtt aatgactcca gcactttgga tattgacttt aaattcatgg aagatattga     2940

gaagtctgaa gctcgcatag gcattcccag tacaaagtat acaaaagaaa caccctttgt     3000

ttttaaatta gaagattacc aagatgccgt tatcattcca agatatcgca attttgatca     3060

gcctcatcga ttttatgtag ctgatgtgta cactgatctt accccactca gtaaatttcc     3120

ttcccctgag tatgaaactt ttgcagaata ttataaaaca aagtacaacc ttgacctaac     3180

caatctcaac cagccactgc tggatgtgga ccacacatct tcaagactta atcttttgac     3240

acctcgacat ttgaatcaga aggggaaagc gcttccttta agcagtgctg agaagaggaa     3300

agccaaatgg gaaagtctgc agaataaaca gatactggtt ccagaactct gtgctataca     3360

tccaattcca gcatcactgt ggagaaaagc tgtttgtctc cccagcatac tttatcgcct     3420

tcactgcctt ttgactgcag aggagctaag agcccagact gccagcgatg ctggcgtggg     3480

agtcagatca cttcctgcgg attttagata ccctaactta gacttcgggt ggaaaaaatc     3540

tattgacagc aaatctttca tctcaatttc taactcctct tcagctgaaa atgataatta     3600

ctgtaagcac agcacaattg tccctgaaaa tgctgcacat caaggtgcta atagaacctc     3660

ctctctagaa aatcatgacc aaatgtctgt gaactgcaga acgttgctca gcgagtcccc     3720

tggtaagctc cacgttgaag tttcagcaga tcttacagca attaatggtc tttcttacaa     3780

tcaaaatctc gccaatggca gttatgattt agctaacaga gacttttgcc aaggaaatca     3840

gctaaattac tacaagcagg aaatacccgt gcaaccaact acctcatatt ccattcagaa     3900

tttatacagt tacgagaacc agccccagcc cagcgatgaa tgtactctcc tgagtaataa     3960

ataccttgat ggaaatgcta acaaatctac ctcagatgga agtcctgtga tggccgtaat     4020

gcctggtacg acagacacta ttcaagtgct caagggcagg atggattctg agcagagccc     4080

ttctattggg tactcctcaa ggactcttgg ccccaatcct ggacttattc ttcaggcttt     4140

gactctgtca aacgctagtg atggatttaa cctggagcgg cttgaaatgc ttggcgactc     4200

ctttttaaag catgccatca ccacatatct attttgcact taccctgatg cgcatgaggg     4260

ccgcctttca tatatgagaa gcaaaaaggt cagcaactgt aatctgtatc gccttggaaa     4320

aaagaaggga ctacccagcc gcatggtggt gtcaatattt gatccccctg tgaattggct     4380

tcctcctggt tatgtagtaa atcaagacaa aagcaacaca gataaatggg aaaaagatga     4440

aatgacaaaa gactgcatgc tggcgaatgg caaactggat gaggattacg aggaggagga     4500

tgaggaggag gagagcctga tgtggagggc tccgaaggaa gaggctgact atgaagatga     4560

tttcctggag tatgatcagg aacatatcag atttatagat aatatgttaa tggggtcagg     4620

agcttttgta aagaaaatct ctctttctcc tttttcaacc actgattctg catatgaatg     4680

gaaaatgccc aaaaaatcct ccttaggtag tatgccattt tcatcagatt ttgaggattt     4740

tgactacagc tcttgggatg caatgtgcta tctggatcct agcaaagctg ttgaagaaga     4800

tgactttgtg gtggggttct ggaatccatc agaagaaaac tgtggtgttg acacgggaaa     4860

gcagtccatt tcttacgact tgcacactga gcagtgtatt gctgacaaaa gcatagcgga     4920

ctgtgtggaa gccctgctgg gctgctattt aaccagctgt ggggagaggg ctgctcagct     4980

tttcctctgt tcactggggc tgaaggtgct cccggtaatt aaaaggactg atcgggaaaa     5040

ggccctgtgc cctactcggg agaatttcaa cagccaacaa aagaaccttt cagtgagctg     5100

tgctgctgct tctgtggcca gttcacgctc ttctgtattg aaagactcgg aatatggttg     5160

tttgaagatt ccaccaagat gtatgtttga tcatccagat gcagataaaa cactgaatca     5220

ccttatatcg gggtttgaaa attttgaaaa gaaaatcaac tacagattca agaataaggc     5280

ttaccttctc caggctttta cacatgcctc ctaccactac aatactatca ctgattgtta     5340

ccagcgctta gaattcctgg gagatgcgat tttggactac ctcataacca agcaccttta     5400

tgaagacccg cggcagcact ccccgggggt cctgacagac ctgcggtctg ccctggtcaa     5460

caacaccatc tttgcatcgc tggctgtaaa gtacgactac cacaagtact tcaaagctgt     5520

ctctcctgag ctcttccatg tcattgatga ctttgtgcag tttcagcttg agaagaatga     5580

aatgcaagga atggattctg agcttaggag atctgaggag gatgaagaga aagaagagga     5640

tattgaagtt ccaaaggcca tgggggatat ttttgagtcg cttgctggtg ccatttacat     5700

ggatagtggg atgtcactgg agacagtctg gcaggtgtac tatcccatga tgcggccact     5760

aatagaaaag ttttctgcaa atgtaccccg ttcccctgtg cgagaattgc ttgaaatgga     5820

accagaaact gccaaattta gcccggctga gagaacttac gacgggaagg tcagagtcac     5880

tgtggaagta gtaggaaagg ggaaatttaa aggtgttggt cgaagttaca ggattgccaa     5940

atctgcagca gcaagaagag ccctccgaag cctcaaagct aatcaacctc aggttcccaa     6000

tagctgaaac cgctttttaa aattcaaaac aagaaacaaa acaaaaaaaa ttaaggggaa     6060

aattatttaa atcggaaagg aagacttaaa gttgttagtg agtggaatga attgaaggca     6120

gaatttaaag tttggttgat aacaggatag ataacagaat aaaacattta acatatgtat     6180

aaaattttgg aactaattgt agttttagtt ttttgcgcaa acacaatctt atcttctttc     6240

ctcacttctg ctttgtttaa atcacaagag tgctttaatg atgacattta gcaagtgctc     6300

aaaataattg acaggttttg tttttttttt tttgagttta tgtcagcttt gcttagtgtt     6360

agaaggccat ggagcttaaa cctccagcag tccctaggat gatgtagatt cttctccatc     6420

tctccgtgtg tgcagtagtg ccagtcctgc agtagttgat aagctgaata gaaagataag     6480

gttttcgaga ggagaagtgc gccaatgttg tcttttcttt ccacgttata ctgtgtaagg     6540

tgatgttccc ggtcgctgtt gcacctgata gtaagggaca gatttttaat gaacattggc     6600

tggcatgttg gtgaatcaca ttttagtttt ctgatgccac atagtcttgc ataaaaaagg     6660

gttcttgcct taaaagtgaa accttcatgg atagtcttta atctctgatc tttttggaac     6720

aaactgtttt acattccttt cattttatta tgcattagac gttgagacag cgtgatactt     6780

acaactcact agtatagttg taacttatta caggatcata ctaaaatttc tgtcatatgt     6840

atactgaaga cattttaaaa accagaatat gtagtctacg gatatttttt atcataaaaa     6900

tgatctttgg ctaaacaccc cattttacta aagtcctcct gccaggtagt tcccactgat     6960

ggaaatgttt atggcaaata attttgcctt ctaggctgtt gctctaacaa aataaacctt     7020

agacatatca cacctaaaat atgctgcaga ttttataatt gattggttac ttatttaaga     7080

agcaaaacac agcaccttta cccttagtct cctcacataa atttcttact atacttttca     7140

taatgttgca tgcatatttc acctaccaaa gctgtgctgt taatgccgtg aaagtttaac     7200

gtttgcgata aactgccgta attttgatac atctgtgatt taggtcatta atttagataa     7260

actagctcat tatttccatc tttggaaaag gaaaaaaaaa aaaacttctt taggcatttg     7320

cctaagtttc tttaattaga cttgtaggca ctcttcactt aaatacctca gttcttcttt     7380

tcttttgcat gcatttttcc cctgtttggt gctatgttta tgtattatgc ttgaaatttt     7440

aatttttttt tttttgcact gtaactataa tacctcttaa tttacctttt taaaagctgt     7500

gggtcagtct tgcactccca tcaacatacc agtagaggtt tgctgcaatt tgccccgtta     7560

attatgcttg aagtttaaga aagctgagca gaggtgtctc atatttccca gcacatgatt     7620

ctgaacttga tgcttcgtgg aatgctgcat ttatatgtaa gtgacatttg aatactgtcc     7680

ttcctgcttt atctgcatca tccacccaca gagaaatgcc tctgtgcgag tgcaccgaca     7740

gaaaactgtc agctctgctt tctaaggaac cctgagtgag gggggtatta agcttctcca     7800

gtgttttttg ttgtctccaa tcttaaactt aaattgagat ctaaattatt aaacgagttt     7860

ttgagcaaat taggtgactt gttttaaaaa tatttaattc cgatttggaa ccttagatgt     7920

ctatttgatt ttttaaaaaa ccttaatgta agatatgacc agttaaaaca aagcaattct     7980

tgaattatat aactgtaaaa gtgtgcagtt aacaaggctg gatgtgaatt ttattctgag     8040

ggtgatttgt gatcaagttt aatcacaaat ctcttaatat ttataaacta cctgatgcca     8100

ggagcttagg gctttgcatt gtgtctaata cattgatccc agtgttacgg gattctcttg     8160

attcctggca ccaaaatcag attgttttca cagttatgat tcccagtggg agaaaaatgc     8220

ctcaatatat ttgtaacctt aagaagagta tttttttgtt aatactaaga tgttcaaact     8280

tagacatgat taggtcatac attctcaggg gttcaaattt ccttctacca ttcaaatgtt     8340

ttatcaacag caaacttcag ccgtttcact ttttgttgga gaaaaatagt agattttaat     8400

ttgactcaca gtttgaagca ttctgtgatc ccctggttac tgagttaaaa aataaaaaag     8460

tacgagttag acatatgaaa tggttatgaa cgcttttgtg ctgctgattt ttaatgctgt     8520

aaagttttcc tgtgtttagc ttgttgaaat gttttgcatc tgtcaattaa ggaaaaaaaa     8580

aatcactcta tgttgcccca ctttagagcc ctgtgtgcca ccctgtgttc ctgtgattgc     8640

aatgtgagac cgaatgtaat atggaaaacc taccagtggg gtgtggttgt gccctgagca     8700

cgtgtgtaaa ggactgggga ggcgtgtctt gaaaaagcaa ctgcagaaat tccttatgat     8760

gattgtgtgc aagttagtta acatgaacct tcatttgtaa attttttaaa atttctttta     8820

taatatgctt tccgcagtcc taactatgct gcgttttata atagcttttt cccttctgtt     8880

ctgttcatgt agcacagata agcattgcac ttggtaccat gctttacctc atttcaagaa     8940

aatatgctta acagagagga aaaaaatgtg gtttggcctt gctgctgttt tgatttatgg     9000

aatttgaaaa agataattat aatgcctgca atgtgtcata tactcgcaca acttaaatag     9060

gtcatttttg tctgtggcat ttttactgtt tgtgaaagta tgaaacagat ttgttaactg     9120

aactcttaat tatgttttta aaatgtttgt tatatttctt ttcttttttc ttttatatta     9180

cgtgaagtga tgaaatttag aatgacctct aacactcctg taattgtctt ttaaaatact     9240

gatattttta tttgttaata atactttgcc ctcagaaaga ttctgatacc ctgccttgac     9300

aacatgaaac ttgaggctgc tttggttcat gaatccaggt gttcccccgg cagtcggctt     9360

cttcagtcgc tccctggagg caggtgggca ctgcagagga tcactggaat ccagatcgag     9420

cgcagttcat gcacaaggcc ccgttgattt aaaatattgg atcttgctct gttagggtgt     9480

ctaatccctt tacacaagat tgaagccacc aaactgagac cttgatacct ttttttaact     9540

gcatctgaaa ttatgttaag agtctttaac ccatttgcat tatctgcaga agagaaactc     9600

atgtcatgtt tattacctat atggttgttt taattacatt tgaataatta tatttttcca     9660

accactgatt acttttcagg aatttaatta tttccagata aatttcttta ttttatattg     9720

tacatgaaaa gttttaaaga tatgtttaag accaagacta ttaaaatgat ttttaaagtt     9780

gttggagacg ccaatagcaa tatctaggaa atttgcattg agaccattgt attttccact     9840

agcagtgaaa atgatttttc acaactaact tgtaaatata ttttaatcat tacttctttt     9900

tttctagtcc atttttattt ggacatcaac cacagacaat ttaaatttta tagatgcact     9960

aagaattcac tgcagcagca ggttacatag caaaaatgca aaggtgaaca ggaagtaaat    10020

ttctggcttt tctgctgtaa atagtgaagg aaaattacta aaatcaagta aaactaatgc    10080

atattatttg attgacaata aaatatttac catcacatgc tgcagctgtt ttttaaggaa    10140

catgatgtca ttcattcata cagtaatcat gctgcagaaa tttgcagtct gcaccttatg    10200

gatcacaatt acctttagtt gttttttttg taataattgt agccaagtaa atctccaata    10260

aagttatcgt ctgttcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa    10320

aaa                                                                  10323


<210>  18
<211>  1374
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  18

Met Asp Ile Ser Ser Phe Leu Leu Pro Gln Leu Leu Arg Lys Tyr Gln 
1               5                   10                  15      


Gln Asp Val Tyr Asn Ile Ala Ser Lys Gln Asn Thr Leu Leu Val Met 
            20                  25                  30          


Arg Thr Gly Ala Gly Lys Thr Leu Leu Ala Val Lys Leu Ile Lys Gln 
        35                  40                  45              


Lys Leu Glu Glu Gln Ile Leu Ile Gln Glu Ser Asn Leu Glu His Lys 
    50                  55                  60                  


Lys Ile Ser Val Phe Leu Val Asn Lys Val Pro Leu Val Phe Gln Gln 
65                  70                  75                  80  


Ala Glu Tyr Ile Arg Ser Gln Leu Pro Ala Lys Val Gly Met Phe Tyr 
                85                  90                  95      


Gly Glu Leu Ser Ile Glu Met Ser Glu Gln Leu Leu Thr Asn Ile Ile 
            100                 105                 110         


Leu Lys Tyr Asn Val Ile Val Ile Thr Ala Asp Leu Phe Tyr Leu Phe 
        115                 120                 125             


Leu Ala Arg Gly Phe Leu Ser Ile Asn Asp Leu Asn Leu Ile Ile Phe 
    130                 135                 140                 


Asp Glu Cys His His Ala Ile Gly Asn Asp Ala Tyr Ala Arg Ile Met 
145                 150                 155                 160 


Asn Asp Phe Tyr His Arg Ala Lys Ala Val Leu Ser Lys Lys His Phe 
                165                 170                 175     


Thr Leu Pro Arg Ile Phe Gly Met Thr Ala Ser Pro Phe Thr Gly Lys 
            180                 185                 190         


Lys Gly Asn Leu Tyr His Arg Leu Tyr Gln Trp Glu Gln Leu Phe Asp 
        195                 200                 205             


Ser Lys Ala His Val Val Ser Glu Asn Glu Leu Ala Asp Tyr Phe Cys 
    210                 215                 220                 


Leu Pro Glu Glu Ser Tyr Val Met Tyr Ser Asn Lys Leu Val Val Pro 
225                 230                 235                 240 


Pro Ser Asp Ser Ile Ile Lys Lys Cys Glu Glu Thr Leu Gln Gly Cys 
                245                 250                 255     


Lys Leu Ile Ser Arg Ala Val Lys Thr Ala Leu Ala Glu Thr Ile Asp 
            260                 265                 270         


Met Gly Leu Trp Phe Gly Glu Gln Val Trp Leu Tyr Leu Val Asp Phe 
        275                 280                 285             


Val Glu Thr Lys Arg Leu Lys Lys Lys Ala Leu Gly Lys Gln Leu Ser 
    290                 295                 300                 


Asp Asp Glu Glu Leu Ala Ile Asp Arg Leu Lys Ile Phe Val Glu Asp 
305                 310                 315                 320 


Trp Lys Asn Asn Lys Tyr Ser Asp Asn Gly Pro Arg Ile Pro Val Phe 
                325                 330                 335     


Asp Ser Thr Asp Val Thr Asp Lys Val Phe Lys Leu Leu Glu Leu Leu 
            340                 345                 350         


Lys Ala Thr Tyr Arg Lys Ser Asp Ser Val Arg Thr Val Ile Phe Val 
        355                 360                 365             


Glu Arg Lys Ala Thr Ala Phe Thr Leu Ser Leu Phe Met Lys Thr Leu 
    370                 375                 380                 


Asn Leu Pro Asn Ile Arg Ala His Ser Phe Ile Gly His Gly Pro Ser 
385                 390                 395                 400 


Asp Gln Gly Glu Phe Ser Met Thr Phe Arg Arg Gln Lys Asp Thr Leu 
                405                 410                 415     


His Lys Phe Lys Thr Gly Lys Tyr Asn Val Leu Ile Ala Thr Ala Val 
            420                 425                 430         


Ala Glu Glu Gly Ile Asp Val Pro Ser Cys Asn Leu Val Ile Arg Phe 
        435                 440                 445             


Asn Ile Cys Arg Thr Val Thr Gln Tyr Val Gln Ser Arg Gly Arg Ala 
    450                 455                 460                 


Arg Ala Met Ala Ser Lys Phe Leu Ile Phe Leu Asn Thr Glu Glu Leu 
465                 470                 475                 480 


Leu Ile His Glu Arg Ile Leu His Glu Glu Lys Asn Leu Lys Phe Ala 
                485                 490                 495     


Leu Ser Glu Leu Ser Asn Ser Asn Ile Phe Asp Ser Leu Val Cys Glu 
            500                 505                 510         


Glu Arg Glu Arg Val Thr Asp Asp Ile Val Tyr Glu Val Gly Glu Thr 
        515                 520                 525             


Gly Ala Leu Leu Thr Gly Leu Tyr Ala Val Ser Leu Leu Tyr Asn Phe 
    530                 535                 540                 


Cys Asn Thr Leu Ser Arg Asp Val Tyr Thr Arg Tyr Tyr Pro Thr Phe 
545                 550                 555                 560 


Thr Ala Gln Pro Cys Leu Ser Gly Trp Tyr Cys Phe Glu Val Glu Leu 
                565                 570                 575     


Pro Lys Ala Cys Lys Val Pro Ala Ala Gln Gly Ser Pro Ala Lys Ser 
            580                 585                 590         


Ile Arg Lys Ala Lys Gln Asn Ala Ala Phe Ile Met Cys Leu Asp Leu 
        595                 600                 605             


Ile Arg Met Gly Leu Ile Asp Lys His Leu Lys Pro Leu Asp Phe Arg 
    610                 615                 620                 


Arg Lys Ile Ala Asp Leu Glu Thr Leu Glu Glu Asp Glu Leu Lys Asp 
625                 630                 635                 640 


Glu Gly Tyr Ile Glu Thr Tyr Glu Arg Tyr Val Pro Lys Ser Trp Met 
                645                 650                 655     


Lys Val Pro Glu Asp Ile Thr Arg Cys Phe Val Ser Leu Leu Tyr Thr 
            660                 665                 670         


Asp Ala Asn Glu Gly Asp Asn His Ile Phe His Pro Leu Val Phe Val 
        675                 680                 685             


Gln Ala His Ser Phe Pro Lys Ile Asp Ser Phe Ile Leu Asn Ser Thr 
    690                 695                 700                 


Val Gly Pro Arg Val Lys Ile Val Leu Glu Thr Ile Glu Asp Ser Phe 
705                 710                 715                 720 


Lys Ile Asp Ser His Leu Leu Glu Leu Leu Lys Lys Ser Thr Arg Tyr 
                725                 730                 735     


Leu Leu Gln Phe Gly Leu Ser Thr Ser Leu Glu Gln Gln Ile Pro Thr 
            740                 745                 750         


Pro Tyr Trp Leu Ala Pro Leu Asn Leu Ser Cys Thr Asp Tyr Arg Phe 
        755                 760                 765             


Leu Glu Asn Leu Ile Asp Val Asp Thr Ile Gln Asn Phe Phe Lys Leu 
    770                 775                 780                 


Pro Glu Pro Val Gln Asn Val Thr Asp Leu Gln Ser Asp Thr Val Leu 
785                 790                 795                 800 


Leu Val Asn Pro Gln Ser Ile Tyr Glu Gln Tyr Ala Phe Glu Gly Phe 
                805                 810                 815     


Val Asn Ser Glu Phe Met Ile Pro Ala Lys Lys Lys Asp Lys Ala Pro 
            820                 825                 830         


Ser Ala Leu Cys Lys Lys Leu Pro Leu Arg Leu Asn Tyr Ser Leu Trp 
        835                 840                 845             


Gly Asn Arg Ala Lys Ser Ile Pro Lys Ser Gln Gln Val Arg Ser Phe 
    850                 855                 860                 


Tyr Ile Asn Asp Leu Tyr Ile Leu Pro Val Ser Arg His Leu Lys Asn 
865                 870                 875                 880 


Ser Ala Leu Leu Ile Pro Ser Ile Leu Tyr His Ile Glu Asn Leu Leu 
                885                 890                 895     


Val Ala Ser Ser Phe Ile Glu His Phe Arg Leu Asp Cys Lys Ile Asp 
            900                 905                 910         


Thr Ala Cys Gln Ala Leu Thr Ser Ala Glu Ser Gln Leu Asn Phe Asp 
        915                 920                 925             


Tyr Asp Arg Leu Glu Phe Tyr Gly Asp Cys Phe Leu Lys Leu Gly Ala 
    930                 935                 940                 


Ser Ile Thr Val Phe Leu Lys Phe Pro Asp Thr Gln Glu Tyr Gln Leu 
945                 950                 955                 960 


His Phe Asn Arg Lys Lys Ile Ile Ser Asn Cys Asn Leu Tyr Lys Val 
                965                 970                 975     


Ala Ile Asp Cys Glu Leu Pro Lys Tyr Ala Leu Ser Thr Pro Leu Glu 
            980                 985                 990         


Ile Arg His Trp Cys Pro Tyr Gly  Phe Gln Lys Ser Thr  Ser Asp Lys 
        995                 1000                 1005             


Cys Arg  Tyr Ala Val Leu Gln  Lys Leu Ser Val Lys  Arg Ile Ala 
    1010                 1015                 1020             


Asp Met  Val Glu Ala Ser Ile  Gly Ala Cys Leu Leu  Asp Ser Gly 
    1025                 1030                 1035             


Leu Asp  Ser Ala Leu Lys Ile  Cys Lys Ser Leu Ser  Val Gly Leu 
    1040                 1045                 1050             


Leu Asp  Ile Ser Asn Trp Asp  Glu Trp Asn Asn Tyr  Phe Asp Leu 
    1055                 1060                 1065             


Asn Thr  Tyr Ala Asp Ser Leu  Arg Asn Val Gln Phe  Pro Tyr Ser 
    1070                 1075                 1080             


Ser Tyr  Ile Glu Glu Thr Ile  Gly Tyr Ser Phe Lys  Asn Lys Lys 
    1085                 1090                 1095             


Leu Leu  His Leu Ala Phe Ile  His Pro Ser Met Met  Ser Gln Gln 
    1100                 1105                 1110             


Gly Ile  Tyr Glu Asn Tyr Gln  Gln Leu Glu Phe Leu  Gly Asp Ala 
    1115                 1120                 1125             


Val Leu  Asp Tyr Ile Ile Val  Gln Tyr Leu Tyr Lys  Lys Tyr Pro 
    1130                 1135                 1140             


Asn Ala  Thr Ser Gly Glu Leu  Thr Asp Tyr Lys Ser  Phe Tyr Val 
    1145                 1150                 1155             


Cys Asn  Lys Ser Leu Ser Tyr  Ile Gly Phe Val Leu  Asn Leu His 
    1160                 1165                 1170             


Lys Tyr  Ile Gln His Glu Ser  Ala Ala Met Cys Asp  Ala Ile Phe 
    1175                 1180                 1185             


Glu Tyr  Gln Glu Leu Ile Glu  Ala Phe Arg Glu Thr  Ala Ser Glu 
    1190                 1195                 1200             


Asn Pro  Trp Phe Trp Phe Glu  Ile Asp Ser Pro Lys  Phe Ile Ser 
    1205                 1210                 1215             


Asp Thr  Leu Glu Ala Met Ile  Cys Ala Ile Phe Leu  Asp Ser Gly 
    1220                 1225                 1230             


Phe Ser  Leu Gln Ser Leu Gln  Phe Val Leu Pro Leu  Phe Leu Asn 
    1235                 1240                 1245             


Ser Leu  Gly Asp Ala Thr His  Thr Lys Ala Lys Gly  Asp Ile Glu 
    1250                 1255                 1260             


His Lys  Val Tyr Gln Leu Leu  Lys Asp Gln Gly Cys  Glu Asp Phe 
    1265                 1270                 1275             


Gly Thr  Lys Cys Val Ile Glu  Glu Val Lys Ser Ser  His Lys Thr 
    1280                 1285                 1290             


Leu Leu  Asn Thr Glu Leu His  Leu Thr Lys Tyr Tyr  Gly Phe Ser 
    1295                 1300                 1305             


Phe Phe  Arg His Gly Asn Ile  Val Ala Tyr Gly Lys  Ser Arg Lys 
    1310                 1315                 1320             


Val Ala  Asn Ala Lys Tyr Ile  Met Lys Gln Arg Leu  Leu Lys Leu 
    1325                 1330                 1335             


Leu Glu  Asp Lys Ser Asn Leu  Leu Leu Tyr Ser Cys  Asn Cys Lys 
    1340                 1345                 1350             


Phe Ser  Lys Lys Lys Pro Ser  Asp Glu Gln Ile Lys  Gly Asp Gly 
    1355                 1360                 1365             


Lys Val  Lys Ser Leu Thr 
    1370                 


<210>  19
<211>  4125
<212>  DNA
<213>  Schizosaccharomyces pombe

<400>  19
atggatattt caagttttct acttcctcaa cttttacgta aatatcaaca agatgtgtat       60

aatatcgcga gcaagcaaaa tactttactt gttatgagaa cgggcgctgg taagacatta      120

cttgctgtga agttgataaa acaaaagctc gaggagcaaa ttttaatcca agaatcaaat      180

cttgaacata aaaaaatatc agtttttctc gtcaacaaag tccctttggt atttcaacaa      240

gcggaataca ttcgatctca actaccggct aaggttggca tgttttatgg cgaattatct      300

atagaaatga gcgagcagtt gttgactaat attatattga agtataatgt gattgttatt      360

actgcagatt tgttctattt gtttcttgca agaggttttc tttcaataaa tgatttgaat      420

ttaattatat tcgacgaatg tcatcatgca attggaaatg atgcgtatgc tcgcatcatg      480

aatgattttt atcacagagc caaagcagta ttgtcaaaaa aacatttcac cctaccaaga      540

atttttggta tgactgcttc accattcact ggaaaaaaag gaaacttata ccatcgactg      600

tatcaatggg agcaattatt tgattctaaa gcacacgtgg tttcggaaaa cgagctagcc      660

gattacttct gtcttcccga agaaagctat gtaatgtatt ccaataagtt ggttgtgcca      720

ccctcggatt ctattatcaa gaaatgcgag gaaactcttc aaggatgcaa gttaatttct      780

cgggctgtta agactgcttt agcagaaacc atagatatgg gtctttggtt tggggagcaa      840

gtttggttat atttggttga ttttgtggaa acgaaaagat taaaaaaaaa ggctttaggg      900

aagcagttgt cagatgacga ggaactggca attgaccggt taaaaatatt tgttgaagat      960

tggaaaaata acaaatattc agacaatggc cctagaatcc ctgtttttga ttccactgat     1020

gttactgata aagtctttaa actcttagaa ttgttaaagg ctacttaccg caaaagtgat     1080

agcgttcgta cggttatttt cgttgaaaga aaagctacgg cgtttacttt aagtttgttt     1140

atgaaaactc ttaatctgcc taacatccgc gctcattctt ttataggaca tggaccgtcc     1200

gatcagggtg aattttctat gacattcagg aggcaaaaag atacccttca taagtttaag     1260

actggaaaat ataatgtttt aattgctact gcagttgcag aagaaggtat cgatgtacca     1320

tcatgtaact tagttatacg cttcaatatt tgtcggactg tcacccagta tgtccaatct     1380

cgaggtagag cgagagcaat ggcttcaaag tttctaattt ttttaaacac agaagagttg     1440

ttaattcatg aacgcattct acacgaagaa aaaaatctta aatttgccct ttcagagctc     1500

agcaattcga atatttttga ttcattggta tgtgaggaaa gagaacgtgt gactgatgat     1560

atcgtctatg aagttggcga gactggtgct ttactcacag ggttgtatgc agttagtctg     1620

ctttataact tttgtaacac actttcaaga gacgtataca caagatatta tcccactttt     1680

acagctcaac cctgtctttc aggttggtat tgttttgagg tagaattgcc aaaagcctgc     1740

aaagttccag cggctcaagg atctcccgct aaatcaatta ggaaagccaa acagaatgct     1800

gcgttcatca tgtgtttgga tctgattcgt atgggtctta tagacaaaca tttaaaaccc     1860

ctagatttta gaagaaaaat tgccgacctt gaaactcttg aggaagacga gctaaaagat     1920

gaaggttata tcgagacata tgagcgctat gtaccaaaaa gttggatgaa agttcctgaa     1980

gatattacac gttgcttcgt ctctttactt tatactgatg ctaatgaagg agacaatcat     2040

atattccatc ccttagtgtt tgtacaagct cattcattcc ccaaaattga tagctttatt     2100

cttaattcga ctgttggccc ccgagttaaa attgttttag aaacgattga ggatagtttt     2160

aagatcgatt ctcatctgct tgagttgtta aaaaaatcaa ctcgttatct acttcaattc     2220

ggtttatcta cttctcttga gcaacaaata cctactcctt actggcttgc gcctttaaat     2280

ttgtcatgca cggattaccg gttcttagaa aatctgatag atgttgacac tatccaaaat     2340

ttttttaaat taccggaacc tgttcaaaat gttactgatt tgcaatccga tactgtatta     2400

ttagtaaatc cacagtcaat atatgaacag tatgcttttg agggatttgt caattctgaa     2460

tttatgattc ctgctaaaaa gaaagataag gccccttctg ccttatgtaa gaaacttcct     2520

ttacgattaa attattcact ttggggcaat agagctaaat ccattcccaa atcacagcaa     2580

gtgcgcagtt tttatatcaa tgacctctat attctcccag tctctagaca tttgaaaaac     2640

agcgccttgc taataccctc catactgtac catattgaaa acttattggt cgcctcttct     2700

tttatcgaac actttcgact tgattgtaaa attgacactg cttgtcaggc tttaacatct     2760

gcggaatcac aattgaattt tgattacgat cgtctagagt tttacggaga ctgctttcta     2820

aaattgggtg cttctattac agtttttttg aaatttcctg atactcaaga gtaccaactg     2880

cattttaatc gaaagaaaat tattagcaac tgtaatttgt ataaagtagc aatagattgt     2940

gagttgccga agtatgctct ctcgactccc ttggaaatcc gtcattggtg tccatatggt     3000

tttcagaaaa gcacatcgga taagtgccgc tacgccgttt tacagaaatt atcggttaag     3060

aggatagcag atatggtcga agctagtatc ggtgcatgtc ttttagacag tggacttgac     3120

tcagcactca agatctgtaa atctttaagc gttggtctgc tggatatcag caattgggat     3180

gagtggaaca attattttga tttaaataca tatgcggatt cactgagaaa tgttcaattc     3240

ccttactcct cgtatataga ggaaactatt ggatattcat ttaaaaacaa gaaactactc     3300

catttggcat ttattcatcc ttccatgatg tctcagcaag gtatttacga aaactatcaa     3360

cagttggagt ttttgggtga tgctgtattg gattacatta tcgtacaata cctttataaa     3420

aagtatccta acgcaacttc tggcgaatta actgattaca aatcttttta tgtgtgtaac     3480

aagagtctat catacattgg ctttgttttg aatttgcaca aatatatcca acatgaaagc     3540

gcagcaatgt gtgatgcaat atttgaatat caagaattaa ttgaagcgtt cagggagact     3600

gcttcagaga atccgtggtt ctggtttgaa attgattcac caaagttcat ttcagatact     3660

ttagaagcta tgatatgtgc catttttttg gattctgggt ttagtttaca atctctacaa     3720

ttcgttttac ctctttttct taattcgtta ggggatgcga cacatactaa ggctaaagga     3780

gatattgaac acaaggtata ccaattactg aaagatcagg gatgtgaaga cttcggaaca     3840

aagtgtgtca tcgaggaggt gaaatccagt cacaaaacat tgttaaatac tgaactccat     3900

ttaacaaagt attatgggtt ttcattcttc cgccacggga atattgttgc ttacggcaaa     3960

tcccgtaaag ttgccaatgc aaagtatatt atgaaacaaa gacttctcaa attgttagag     4020

gataagtcta acttactttt gtattcttgt aattgcaaat ttagtaagaa aaagccatca     4080

gatgagcaaa taaaaggaga tggaaaagtt aaaagtttga cttga                     4125


<210>  20
<211>  754
<212>  PRT
<213>  Giardia lamblia virus

<400>  20

Met His Ala Leu Gly His Cys Cys Thr Val Val Thr Thr Arg Gly Pro 
1               5                   10                  15      


Ser His Trp Leu Leu Leu Leu Asp Thr His Leu Gly Thr Leu Pro Gly 
            20                  25                  30          


Phe Lys Val Ser Ala Gly Arg Gly Leu Pro Ala Ala Glu Val Tyr Phe 
        35                  40                  45              


Glu Ala Gly Pro Arg Val Ser Leu Ser Arg Thr Asp Ala Thr Ile Val 
    50                  55                  60                  


Ala Val Tyr Gln Ser Ile Leu Phe Gln Leu Leu Gly Pro Thr Phe Pro 
65                  70                  75                  80  


Ala Ser Trp Thr Glu Ile Gly Ala Thr Met Pro His Asn Glu Tyr Thr 
                85                  90                  95      


Phe Pro Arg Phe Ile Ser Asn Pro Pro Gln Phe Ala Thr Leu Ala Phe 
            100                 105                 110         


Leu Pro Leu Leu Ser Pro Thr Ser Pro Leu Asp Leu Arg Ala Leu Met 
        115                 120                 125             


Val Thr Ala Gln Leu Met Cys Asp Ala Lys Arg Leu Ser Asp Glu Tyr 
    130                 135                 140                 


Thr Asp Tyr Ser Thr Leu Ser Ala Ser Leu His Gly Arg Met Val Ala 
145                 150                 155                 160 


Thr Pro Glu Ile Ser Trp Ser Leu Tyr Val Val Leu Gly Ile Asp Ser 
                165                 170                 175     


Thr Gln Thr Ser Leu Ser Tyr Phe Thr Arg Ala Asn Glu Ser Ile Thr 
            180                 185                 190         


Tyr Met Arg Tyr Tyr Ala Thr Ala His Asn Ile His Leu Arg Ala Ala 
        195                 200                 205             


Asp Leu Pro Leu Val Ala Ala Val Arg Leu Asp Asp Leu Lys Asp His 
    210                 215                 220                 


Gln Ile Pro Ala Pro Gly Ser Trp Asp Asp Leu Ala Pro Lys Leu Arg 
225                 230                 235                 240 


Phe Leu Pro Pro Glu Leu Cys Leu Leu Leu Pro Asp Glu Phe Asp Leu 
                245                 250                 255     


Ile Arg Val Gln Ala Leu Gln Phe Leu Pro Glu Ile Ala Lys His Ile 
            260                 265                 270         


Cys Asp Ile Gln Asn Thr Ile Cys Ala Leu Asp Lys Ser Phe Pro Asp 
        275                 280                 285             


Cys Gly Arg Ile Gly Gly Glu Arg Tyr Phe Ala Ile Thr Ala Gly Leu 
    290                 295                 300                 


Arg Leu Asp Gln Gly Arg Gly Arg Gly Leu Ala Gly Trp Arg Thr Pro 
305                 310                 315                 320 


Phe Gly Pro Phe Gly Val Ser His Thr Asp Val Phe Gln Arg Leu Glu 
                325                 330                 335     


Leu Leu Gly Asp Ala Val Leu Gly Phe Ile Val Thr Ala Arg Leu Leu 
            340                 345                 350         


Cys Leu Phe Pro Asp Ala Ser Val Gly Thr Leu Val Glu Leu Lys Met 
        355                 360                 365             


Glu Leu Val Arg Asn Glu Ala Leu Asn Tyr Leu Val Gln Thr Leu Gly 
    370                 375                 380                 


Leu Pro Gln Leu Ala Glu Phe Ser Asn Asn Leu Val Ala Lys Ser Lys 
385                 390                 395                 400 


Thr Trp Ala Asp Met Tyr Glu Glu Ile Val Gly Ser Ile Phe Thr Gly 
                405                 410                 415     


Pro Asn Gly Ile Tyr Gly Cys Glu Glu Phe Leu Ala Lys Thr Leu Met 
            420                 425                 430         


Ser Pro Glu His Ser Lys Thr Val Gly Ser Ala Cys Pro Asp Ala Val 
        435                 440                 445             


Thr Lys Ala Ser Lys Arg Val Cys Met Gly Glu Ala Gly Ala His Glu 
    450                 455                 460                 


Phe Arg Ser Leu Val Asp Tyr Ala Cys Glu Gln Gly Ile Ser Val Phe 
465                 470                 475                 480 


Cys Ser Ser Arg Val Ser Thr Met Phe Leu Glu Arg Leu Arg Asp Ile 
                485                 490                 495     


Pro Ala Glu Asp Met Leu Asp Trp Tyr Arg Leu Gly Ile Gln Phe Ser 
            500                 505                 510         


His Arg Ser Gly Leu Ser Gly Pro Gly Gly Val Val Ser Val Ile Asp 
        515                 520                 525             


Ile Met Thr His Leu Ala Arg Gly Leu Trp Leu Gly Ser Pro Gly Phe 
    530                 535                 540                 


Tyr Val Glu Gln Gln Thr Asp Lys Asn Glu Ser Ala Cys Pro Pro Thr 
545                 550                 555                 560 


Ile Pro Val Leu Tyr Ile Tyr His Arg Ser Val Gln Cys Pro Val Leu 
                565                 570                 575     


Tyr Gly Ser Leu Thr Glu Thr Pro Thr Gly Pro Val Ala Ser Lys Val 
            580                 585                 590         


Leu Ala Leu Tyr Glu Lys Ile Leu Ala Tyr Glu Ser Ser Gly Gly Ser 
        595                 600                 605             


Lys His Ile Ala Ala Gln Thr Val Ser Arg Ser Leu Ala Val Pro Ile 
    610                 615                 620                 


Pro Ser Gly Thr Ile Pro Phe Leu Ile Arg Leu Leu Gln Ile Ala Leu 
625                 630                 635                 640 


Thr Pro His Val Tyr Gln Lys Leu Glu Leu Leu Gly Asp Ala Phe Leu 
                645                 650                 655     


Lys Cys Ser Leu Ala Leu His Leu His Ala Leu His Pro Thr Leu Thr 
            660                 665                 670         


Glu Gly Ala Leu Thr Arg Met Arg Gln Ser Ala Glu Thr Asn Ser Val 
        675                 680                 685             


Leu Gly Arg Leu Thr Lys Arg Phe Pro Ser Val Val Ser Glu Val Ile 
    690                 695                 700                 


Ile Glu Ser His Pro Lys Ile Gln Pro Asp Ser Lys Val Tyr Gly Asp 
705                 710                 715                 720 


Thr Phe Glu Ala Ile Leu Ala Ala Ile Leu Leu Ala Cys Gly Glu Glu 
                725                 730                 735     


Ala Ala Gly Ala Phe Val Arg Glu His Val Leu Pro Gln Val Val Ala 
            740                 745                 750         


Asp Ala 
        


<210>  21
<211>  2265
<212>  DNA
<213>  Giardia lamblia virus

<400>  21
atgcatgctt tgggacactg ttgcacagtt gtgactacta gaggaccatc ccactggttg       60

ctacttctag acactcacct gggcaccttg ccagggttta aggttagtgc aggccgaggg      120

cttcccgccg cagaggtgta ctttgaagcg ggtccgaggg tgtctctctc tcgaactgat      180

gcaactatag tagccgtgta tcagtccatt ctctttcagc tgctgggacc cacatttcct      240

gcttcatgga ctgagattgg agcaacaatg cctcacaatg aatacacttt ccctcgattt      300

atatccaatc caccacaatt cgccaccctg gcatttttac ccttactatc tcctaccagc      360

cctctggact tgcgtgcatt aatggtcact gcacaactca tgtgtgatgc aaagcgcttg      420

tcagatgaat atacagacta ttccacttta tctgcatccc tccatgggcg tatggttgca      480

actcccgaaa taagctggtc tctttatgtc gttcttggga tcgattctac ccaaactagc      540

ctttcttact ttaccagagc aaatgaatca ataacataca tgagatacta tgcaacagcc      600

cacaatattc acctgcgtgc tgcagatctt ccgcttgtgg cagcagtcag attagacgat      660

ctaaaagacc accagattcc cgcgcctgga tcctgggatg atttggctcc caagcttcgc      720

ttcctgccgc ctgagctctg cctactgctg ccagatgaat ttgatctaat cagggtccag      780

gcgcttcaat ttctaccaga gattgctaag cacatatgtg acatacagaa tacaatctgt      840

gccctggata aaagctttcc tgactgtggg cggatcggtg gcgagcgata ctttgcaatc      900

actgccggac ttcggctcga tcaggggcgt ggacgagggc ttgccggttg gagaacaccc      960

tttgggcctt ttggtgtaag tcacaccgat gttttccagc gactcgaatt gctaggagat     1020

gctgtgttag gctttatcgt gactgcccgc ctcctttgcc tttttccaga tgcgtctgtg     1080

ggaacacttg ttgagctaaa gatggagctt gttcgcaatg aggctctaaa ctatcttgta     1140

caaacgcttg gacttcctca gttggcggag ttttccaaca accttgtggc gaagagcaaa     1200

acatgggcag atatgtatga ggagatcgtt ggatcaatct ttacgggacc taatggaatc     1260

tatggctgtg aggaatttct tgcgaagacg cttatgagtc ccgaacactc caagacagta     1320

ggatctgcct gtccagatgc agtcaccaag gcatcaaagc gtgtttgcat gggagaagcg     1380

ggggcgcatg aattcagaag ccttgtggac tatgcttgtg agcaaggcat tagtgtcttc     1440

tgttcttcgc gggtgtcaac tatgtttctc gagcgtctca gagacattcc agcagaggac     1500

atgctagatt ggtaccgact tggtatccag ttttcgcatc gttcaggcct atcaggacct     1560

ggcggcgtcg tatcagttat agacataatg acacatttgg ctcgaggcct atggctgggc     1620

tctccaggct tctatgttga acagcaaact gataagaatg agtcggcttg tccgcccact     1680

atacctgttt tatatatcta tcatcgctct gtgcagtgtc ctgttttata tgggtcgctc     1740

acagaaaccc ctacagggcc cgttgcttct aaggttctcg ctctctatga gaagattctg     1800

gcatatgagt catcaggagg tagtaagcat atagcagctc agacagttag cagatctctg     1860

gccgtaccca ttcctagtgg cactatcccc ttcctgattc ggttattgca aatagcacta     1920

actcctcacg tgtaccaaaa acttgagctt cttggagacg cattcctgaa gtgcagcctt     1980

gctctccatc tccacgctct ccaccccacg ctcacagagg gcgctcttac acgcatgcgg     2040

caatctgcag aaacaaattc tgtactggga agattgacaa aaaggtttcc ttctgtagtt     2100

tctgaggtta ttatagaatc ccatccgaaa atacagcctg acagcaaggt ttatggcgat     2160

acatttgaag ccattttggc agcaattctt cttgcgtgcg gggaagaggc agcaggtgct     2220

tttgttcgag agcatgttct cccacaagta gtagctgatg cgtag                     2265


<210>  22
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  22
cccgggttca cgccattctc ctgcctcagc ctcacgagta gctgggacta caggcgcccg       60

acaccactcc cggctaattt tttgtatttt t                                      91


<210>  23
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide

<400>  23
tgaggtcagg agatcgagac catcccggc                                         29


<210>  24
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  24
tgaggtcagg agatcgaaac catcccggc                                         29


<210>  25
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  25
tgaggtcagg agttcgaaac catcccggc                                         29


<210>  26
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide

<400>  26
tgaggtcagg agttcgagac catcccggc                                         29


