                         SEQUENCE LISTING

<110>  VIB VZW
       KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
 
<120>  THE USE OF TRANSPORTERS TO MODULATE FLAVOR PRODUCTION BY YEAST

<130>  JoTh/DIA/344

<150>  EP 10164511.7
<151>  2010-05-31

<150>  US 61/465,803
<151>  2011-03-23

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  799
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Ser Thr Ile Tyr Arg Glu Ser Asp Ser Leu Glu Ser Glu Pro Ser 
1               5                   10                  15      


Pro Thr Pro Thr Thr Ile Pro Ile Gln Ile Asn Met Glu Glu Glu Lys 
            20                  25                  30          


Lys Asp Ala Phe Val Lys Asn Ile Asp Glu Asp Val Asn Asn Leu Thr 
        35                  40                  45              


Ala Thr Thr Asp Glu Glu Asp Arg Asp Pro Glu Ser Gln Lys Phe Asp 
    50                  55                  60                  


Arg His Ser Ile Gln Glu Glu Gly Leu Val Trp Lys Gly Asp Pro Thr 
65                  70                  75                  80  


Tyr Leu Pro Asn Ser Pro Tyr Pro Glu Val Arg Ser Ala Val Ser Ile 
                85                  90                  95      


Glu Asp Asp Pro Thr Ile Arg Leu Asn His Trp Arg Thr Trp Phe Leu 
            100                 105                 110         


Thr Thr Val Phe Val Val Val Phe Ala Gly Val Asn Gln Phe Phe Ser 
        115                 120                 125             


Leu Arg Tyr Pro Ser Leu Glu Ile Asn Phe Leu Val Ala Gln Val Val 
    130                 135                 140                 


Cys Tyr Pro Ile Gly Arg Ile Leu Ala Leu Leu Pro Asp Trp Lys Cys 
145                 150                 155                 160 


Ser Lys Val Pro Phe Phe Asp Leu Asn Pro Gly Pro Phe Thr Lys Lys 
                165                 170                 175     


Glu His Ala Val Val Thr Ile Ala Val Ala Leu Thr Ser Ser Thr Ala 
            180                 185                 190         


Tyr Ala Met Tyr Ile Leu Asn Ala Gln Gly Ser Phe Tyr Asn Met Lys 
        195                 200                 205             


Leu Asn Val Gly Tyr Gln Phe Leu Leu Val Trp Thr Ser Gln Met Ile 
    210                 215                 220                 


Gly Tyr Gly Ala Ala Gly Leu Thr Arg Arg Trp Val Val Asn Pro Ala 
225                 230                 235                 240 


Ser Ser Ile Trp Pro Gln Thr Leu Ile Ser Val Ser Leu Phe Asp Ser 
                245                 250                 255     


Leu His Ser Arg Lys Val Glu Lys Thr Val Ala Asn Gly Trp Thr Met 
            260                 265                 270         


Pro Arg Tyr Arg Phe Phe Leu Ile Val Leu Ile Gly Ser Phe Ile Trp 
        275                 280                 285             


Tyr Trp Val Pro Gly Phe Leu Phe Thr Gly Leu Ser Tyr Phe Asn Val 
    290                 295                 300                 


Ile Leu Trp Gly Ser Lys Thr Arg His Asn Phe Ile Ala Asn Thr Ile 
305                 310                 315                 320 


Phe Gly Thr Gln Ser Gly Leu Gly Ala Leu Pro Ile Thr Phe Asp Tyr 
                325                 330                 335     


Thr Gln Val Ser Gln Ala Met Ser Gly Ser Val Phe Ala Thr Pro Phe 
            340                 345                 350         


Tyr Val Ser Ala Asn Thr Tyr Ala Ser Val Leu Ile Phe Phe Val Ile 
        355                 360                 365             


Val Leu Pro Cys Leu Tyr Phe Thr Asn Thr Trp Tyr Ala Lys Tyr Met 
    370                 375                 380                 


Pro Val Ile Ser Gly Ser Thr Tyr Asp Asn Thr Gln Asn Lys Tyr Asn 
385                 390                 395                 400 


Val Thr Lys Ile Leu Asn Glu Asp Tyr Ser Ile Asn Leu Glu Lys Tyr 
                405                 410                 415     


Lys Glu Tyr Ser Pro Val Phe Val Pro Phe Ser Tyr Leu Leu Ser Tyr 
            420                 425                 430         


Ala Leu Asn Phe Ala Ala Val Ile Ala Val Phe Val His Cys Ile Leu 
        435                 440                 445             


Tyr His Gly Lys Asp Ile Val Ala Lys Phe Lys Asp Arg Lys Asn Gly 
    450                 455                 460                 


Gly Thr Asp Ile His Met Arg Ile Tyr Ser Lys Asn Tyr Lys Asp Cys 
465                 470                 475                 480 


Pro Asp Trp Trp Tyr Leu Leu Leu Gln Ile Val Met Ile Gly Leu Gly 
                485                 490                 495     


Phe Val Ala Val Cys Cys Phe Asp Thr Lys Phe Pro Ala Trp Ala Phe 
            500                 505                 510         


Val Ile Ala Ile Leu Ile Ser Leu Val Asn Phe Ile Pro Gln Gly Ile 
        515                 520                 525             


Leu Glu Ala Met Thr Asn Gln His Val Gly Leu Asn Ile Ile Thr Glu 
    530                 535                 540                 


Leu Ile Cys Gly Tyr Met Leu Pro Leu Arg Pro Met Ala Asn Leu Leu 
545                 550                 555                 560 


Phe Lys Leu Tyr Gly Phe Ile Val Met Arg Gln Gly Leu Asn Leu Ser 
                565                 570                 575     


Arg Asp Leu Lys Leu Ala Met Tyr Met Lys Val Ser Pro Arg Leu Ile 
            580                 585                 590         


Phe Ala Val Gln Ile Tyr Ala Thr Ile Ile Ser Gly Met Val Asn Val 
        595                 600                 605             


Gly Val Gln Glu Trp Met Met His Asn Ile Asp Gly Leu Cys Thr Thr 
    610                 615                 620                 


Asp Gln Pro Asn Gly Phe Thr Cys Ala Asn Gly Arg Thr Val Phe Asn 
625                 630                 635                 640 


Ala Ser Ile Ile Trp Ser Leu Pro Lys Tyr Leu Phe Ser Ser Gly Arg 
                645                 650                 655     


Ile Tyr Asn Pro Leu Met Trp Phe Phe Leu Ile Gly Leu Leu Phe Pro 
            660                 665                 670         


Leu Ala Val Tyr Ala Val Gln Trp Lys Phe Pro Lys Phe Lys Phe Ala 
        675                 680                 685             


Lys His Ile His Thr Pro Val Phe Phe Thr Gly Pro Gly Asn Ile Pro 
    690                 695                 700                 


Pro Ser Thr Pro Tyr Asn Tyr Ser Leu Phe Phe Ala Met Ser Phe Cys 
705                 710                 715                 720 


Leu Asn Leu Ile Arg Lys Arg Trp Arg Ala Trp Phe Asn Lys Tyr Asn 
                725                 730                 735     


Phe Val Met Gly Ala Gly Val Glu Ala Gly Val Ala Ile Ser Val Val 
            740                 745                 750         


Ile Ile Phe Leu Cys Val Gln Tyr Pro Gly Gly Lys Leu Ser Trp Trp 
        755                 760                 765             


Gly Asn Asn Val Trp Lys Arg Thr Tyr Asp Asn Asp Tyr Lys Lys Phe 
    770                 775                 780                 


Tyr Thr Leu Lys Lys Gly Glu Thr Phe Gly Tyr Asp Lys Trp Trp 
785                 790                 795                 


<210>  2
<211>  877
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  2

Met Ser Glu Thr Val Lys Asp Lys Val Ile Ile Asp Glu Lys Val Ser 
1               5                   10                  15      


Thr Lys Gly Thr Val Asp Tyr Ala Glu Gly Ala Glu Tyr Ser Glu Arg 
            20                  25                  30          


Leu Ser Asn His Ser Ser Asp Phe Ser Gln Trp Tyr Thr Asp Glu Gln 
        35                  40                  45              


Ile Leu His Phe Met Lys Lys Leu Gly Tyr Glu Asn Arg Thr Leu Tyr 
    50                  55                  60                  


Asp Ile Pro Glu Asp Val Ala Tyr Ile Leu Lys Lys Met Pro Glu Leu 
65                  70                  75                  80  


Thr Leu Glu Asp Ser Phe Lys Ile Leu Lys Asp Ser Ile Ile Tyr Phe 
                85                  90                  95      


Lys Asp Asp Glu Asn Ile Pro His Asp Gln Tyr Glu Glu Trp Lys Arg 
            100                 105                 110         


Leu Val Asp Leu Glu Asp Leu Asp Ser Lys Glu Gly Ile Asp Glu Tyr 
        115                 120                 125             


Asp Ser Phe Asp Ile Arg Ala Phe Ala Ser Ala Ile Lys Phe His Ser 
    130                 135                 140                 


Pro Tyr Gln Glu Val Arg Ala Val Val Asp Pro Glu Asp Asp Pro Thr 
145                 150                 155                 160 


Ile Pro Val Glu Thr Phe Arg Ala Tyr Phe Leu Ala Ile Ile Trp Ser 
                165                 170                 175     


Val Ile Gly Ser Gly Phe Asn Glu Phe Phe Ser His Arg Val Val Ser 
            180                 185                 190         


Ile Ser Leu Asn Thr Pro Ile Ile Gln Met Phe Leu Tyr Ile Cys Gly 
        195                 200                 205             


Lys Ala Trp Ala Lys Thr Ile Pro Cys Trp Thr Ile Thr Ile Arg Gly 
    210                 215                 220                 


Arg Lys Tyr Gly Ile Asn Ile Asp Lys Pro Trp Thr Gln Lys Glu Gln 
225                 230                 235                 240 


Met Phe Ser Thr Leu Leu Tyr Ala Ile Cys Gln Gly Ala Phe Tyr Thr 
                245                 250                 255     


His Tyr Asn Ile Leu Thr Gln Lys Leu Phe Tyr His Ser Ala Phe Ser 
            260                 265                 270         


Phe Gly Tyr Gln Phe Leu Leu Ser Leu Ser Val Gln Phe Ile Gly Phe 
        275                 280                 285             


Gly Phe Ala Gly Ile Leu Arg Lys Phe Val Val Tyr Pro Ala Arg Ala 
    290                 295                 300                 


Leu Trp Pro Thr Val Met Pro Thr Ile Ala Ile Asn Lys Ala Leu Leu 
305                 310                 315                 320 


Gly Lys Glu Lys His Glu Ser Gly Met Ser Arg Tyr Lys Phe Phe Phe 
                325                 330                 335     


Leu Thr Phe Phe Ile Met Phe Ile Tyr Asn Trp Phe Pro Thr Tyr Ile 
            340                 345                 350         


Ile Asn Ile Leu Asn Thr Phe Asn Trp Met Thr Trp Ile Lys Pro Ser 
        355                 360                 365             


Asn Ile Asn Leu Ala Asn Ile Thr Gly Gly Val Thr Gly Leu Gly Ile 
    370                 375                 380                 


Asn Pro Ile Ser Ser Phe Asp Trp Asn Val Ile Ser Phe Asn Ser Pro 
385                 390                 395                 400 


Leu Val Tyr Pro Phe Trp Ser Tyr Leu Thr Gln Tyr Leu Gly Cys Ile 
                405                 410                 415     


Leu Ala Ala Leu Ile Val Ile Ala Val Tyr Tyr Ser Asn Tyr Met Ser 
            420                 425                 430         


Cys Gln Tyr Leu Pro Ile Phe Thr Asn Ser Leu Tyr Thr Asn Thr Gly 
        435                 440                 445             


His Ser Phe Lys Val Thr Glu Val Leu Asp Ser Asp Asn Lys Leu Asp 
    450                 455                 460                 


Val Lys Lys Tyr Gln Ser Tyr Ser Pro Pro Tyr Tyr Ser Ala Gly Asn 
465                 470                 475                 480 


Leu Val Ser Tyr Gly Ala Phe Ile Cys Ala Tyr Pro Leu Met Ile Thr 
                485                 490                 495     


Trp Ser Phe Ile Val His Ser Lys Leu Leu Phe Asn Ala Phe Lys Asp 
            500                 505                 510         


Trp Ala Leu Asn Leu Trp Ala Met Arg Lys Leu Lys Ser Trp Val Thr 
        515                 520                 525             


Met Phe Lys Ser Asp Tyr Arg Ala Leu Asp Asp Tyr Asp Asp Pro His 
    530                 535                 540                 


Ser Asn Ala Met Lys Asn Tyr Lys Glu Val Pro Asp Trp Trp Tyr Phe 
545                 550                 555                 560 


Ala Ile Leu Ile Gly Ser Leu Val Val Gly Ile Ala Val Val Glu His 
                565                 570                 575     


Tyr Pro Thr Asn Thr Pro Val Trp Gly Leu Phe Val Cys Leu Gly Phe 
            580                 585                 590         


Asn Phe Val Phe Leu Ile Pro Thr Thr Ile Leu Gln Ala Thr Thr Gly 
        595                 600                 605             


Tyr Ser Phe Gly Leu Asn Leu Leu Ile Glu Met Val Met Gly Tyr Ala 
    610                 615                 620                 


Leu Pro Gly Asn Pro Ile Ala Ile Met Ile Leu Lys Ala Phe Gly Tyr 
625                 630                 635                 640 


Asn Ile Asp Gly Gln Ala Asp Asn Tyr Val Ser Asn Leu Lys Ile Ala 
                645                 650                 655     


His Tyr Cys Lys Ile Pro Pro Met Ala Leu Phe Arg Gly Gln Cys Val 
            660                 665                 670         


Ile Val Phe Ile Gln Ile Phe Val Asn Leu Gly Val Leu Asn Trp Gln 
        675                 680                 685             


Ile Ser Asn Ile Lys Asp Phe Cys Thr Pro His Gln Asn Ala Lys Phe 
    690                 695                 700                 


Thr Cys Pro Asp Ala Val Thr Tyr Tyr Asn Ala Ser Val Val Trp Gly 
705                 710                 715                 720 


Ala Ile Gly Pro Lys Arg Ile Phe Asn Tyr Ile Tyr Pro Ile Phe Lys 
                725                 730                 735     


Trp Cys Trp Leu Ile Gly Ala Cys Ile Gly Ile Phe Phe Gly Val Trp 
            740                 745                 750         


Lys Arg Trp Gly Lys Phe Tyr Pro Arg Tyr Phe Asp Pro Met Leu Phe 
        755                 760                 765             


Val Gly Gly Met Leu Asn Met Ser Pro Pro Tyr Asn Leu Met Tyr Tyr 
    770                 775                 780                 


Thr Ser Gly Met Ile Val Ser Tyr Ile Ser Gln Tyr Tyr Met Lys Arg 
785                 790                 795                 800 


His His Leu Asn Leu Trp Glu Lys Tyr Asn Tyr Val Leu Ser Ala Gly 
                805                 810                 815     


Phe Ser Thr Gly Leu Val Leu Ser Ala Ile Ile Ile Phe Phe Ala Val 
            820                 825                 830         


Gln Tyr Lys Asp Thr Ala Phe Asn Trp Trp Gly Asn Thr Val Pro Tyr 
        835                 840                 845             


Ala Gly Ala Asp Gly Val Gly Tyr Pro Leu Lys Asn Ile Thr Asp Thr 
    850                 855                 860                 


Ala Asn Gly Tyr Phe Gly Tyr Ala Pro Gly His Tyr Pro 
865                 870                 875         


<210>  3
<211>  1049
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Gly Ser His Arg Arg Tyr Leu Tyr Tyr Ser Ile Leu Ser Phe Leu 
1               5                   10                  15      


Leu Leu Ser Cys Ser Val Val Leu Ala Lys Gln Asp Lys Thr Pro Phe 
            20                  25                  30          


Phe Glu Gly Thr Ser Ser Lys Asn Ser Arg Leu Thr Ala Gln Asp Lys 
        35                  40                  45              


Gly Asn Asp Thr Cys Pro Pro Cys Phe Asn Cys Met Leu Pro Ile Phe 
    50                  55                  60                  


Glu Cys Lys Gln Phe Ser Glu Cys Asn Ser Tyr Thr Gly Arg Cys Glu 
65                  70                  75                  80  


Cys Ile Glu Gly Phe Ala Gly Asp Asp Cys Ser Leu Pro Leu Cys Gly 
                85                  90                  95      


Gly Leu Ser Pro Asp Glu Ser Gly Asn Lys Asp Arg Pro Ile Arg Ala 
            100                 105                 110         


Gln Asn Asp Thr Cys His Cys Asp Asn Gly Trp Gly Gly Ile Asn Cys 
        115                 120                 125             


Asp Val Cys Gln Glu Asp Phe Val Cys Asp Ala Phe Met Pro Asp Pro 
    130                 135                 140                 


Ser Ile Lys Gly Thr Cys Tyr Lys Asn Gly Met Ile Val Asp Lys Val 
145                 150                 155                 160 


Phe Ser Gly Cys Asn Val Thr Asn Glu Lys Ile Leu Gln Ile Leu Asn 
                165                 170                 175     


Gly Lys Ile Pro Gln Ile Thr Phe Ala Cys Asp Lys Pro Asn Gln Glu 
            180                 185                 190         


Cys Asn Phe Gln Phe Trp Ile Asp Gln Leu Glu Ser Phe Tyr Cys Gly 
        195                 200                 205             


Leu Ser Asp Cys Ala Phe Glu Tyr Asp Leu Glu Gln Asn Thr Ser His 
    210                 215                 220                 


Tyr Lys Cys Asn Asp Val Gln Cys Lys Cys Val Pro Asp Thr Val Leu 
225                 230                 235                 240 


Cys Gly Ala Lys Gly Ser Ile Asp Ile Ser Asp Phe Leu Thr Glu Thr 
                245                 250                 255     


Ile Lys Gly Pro Gly Asp Phe Ser Cys Asp Leu Glu Thr Arg Gln Cys 
            260                 265                 270         


Lys Phe Ser Glu Pro Ser Met Asn Asp Leu Ile Leu Thr Val Phe Gly 
        275                 280                 285             


Asp Pro Tyr Ile Thr Leu Lys Cys Glu Ser Gly Glu Cys Val His Tyr 
    290                 295                 300                 


Ser Glu Ile Pro Gly Tyr Lys Ser Pro Ser Lys Asp Pro Thr Val Ser 
305                 310                 315                 320 


Trp Gln Gly Lys Leu Val Leu Ala Leu Thr Ala Val Met Val Leu Ala 
                325                 330                 335     


Leu Phe Thr Phe Ala Thr Phe Tyr Ile Ser Lys Ser Pro Leu Phe Arg 
            340                 345                 350         


Asn Gly Leu Gly Ser Ser Lys Ser Pro Ile Arg Leu Pro Asp Glu Asp 
        355                 360                 365             


Ala Val Asn Asn Phe Leu Gln Asn Glu Asp Asp Thr Leu Ala Thr Leu 
    370                 375                 380                 


Ser Phe Glu Asn Ile Thr Tyr Ser Val Pro Ser Ile Asn Ser Asp Gly 
385                 390                 395                 400 


Val Glu Glu Thr Val Leu Asn Glu Ile Ser Gly Ile Val Lys Pro Gly 
                405                 410                 415     


Gln Ile Leu Ala Ile Met Gly Gly Ser Gly Ala Gly Lys Thr Thr Leu 
            420                 425                 430         


Leu Asp Ile Leu Ala Met Lys Arg Lys Thr Gly His Val Ser Gly Ser 
        435                 440                 445             


Ile Lys Val Asn Gly Ile Ser Met Asp Arg Lys Ser Phe Ser Lys Ile 
    450                 455                 460                 


Ile Gly Phe Val Asp Gln Asp Asp Phe Leu Leu Pro Thr Leu Thr Val 
465                 470                 475                 480 


Phe Glu Thr Val Leu Asn Ser Ala Leu Leu Arg Leu Pro Lys Ala Leu 
                485                 490                 495     


Ser Phe Glu Ala Lys Lys Ala Arg Val Tyr Lys Val Leu Glu Glu Leu 
            500                 505                 510         


Arg Ile Ile Asp Ile Lys Asp Arg Ile Ile Gly Asn Glu Phe Asp Arg 
        515                 520                 525             


Gly Ile Ser Gly Gly Glu Lys Arg Arg Val Ser Ile Ala Cys Glu Leu 
    530                 535                 540                 


Val Thr Ser Pro Leu Val Leu Phe Leu Asp Glu Pro Thr Ser Gly Leu 
545                 550                 555                 560 


Asp Ala Ser Asn Ala Asn Asn Val Ile Glu Cys Leu Val Arg Leu Ser 
                565                 570                 575     


Ser Asp Tyr Asn Arg Thr Leu Val Leu Ser Ile His Gln Pro Arg Ser 
            580                 585                 590         


Asn Ile Phe Tyr Leu Phe Asp Lys Leu Val Leu Leu Ser Lys Gly Glu 
        595                 600                 605             


Met Val Tyr Ser Gly Asn Ala Lys Lys Val Ser Glu Phe Leu Arg Asn 
    610                 615                 620                 


Glu Gly Tyr Ile Cys Pro Asp Asn Tyr Asn Ile Ala Asp Tyr Leu Ile 
625                 630                 635                 640 


Asp Ile Thr Phe Glu Ala Gly Pro Gln Gly Lys Arg Arg Arg Ile Arg 
                645                 650                 655     


Asn Ile Ser Asp Leu Glu Ala Gly Thr Asp Thr Asn Asp Ile Asp Asn 
            660                 665                 670         


Thr Ile His Gln Thr Thr Phe Thr Ser Ser Asp Gly Thr Thr Gln Arg 
        675                 680                 685             


Glu Trp Ala His Leu Ala Ala His Arg Asp Glu Ile Arg Ser Leu Leu 
    690                 695                 700                 


Arg Asp Glu Glu Asp Val Glu Gly Thr Asp Gly Arg Arg Gly Ala Thr 
705                 710                 715                 720 


Glu Ile Asp Leu Asn Thr Lys Leu Leu His Asp Lys Tyr Lys Asp Ser 
                725                 730                 735     


Val Tyr Tyr Ala Glu Leu Ser Gln Glu Ile Glu Glu Val Leu Ser Glu 
            740                 745                 750         


Gly Asp Glu Glu Ser Asn Val Leu Asn Gly Asp Leu Pro Thr Gly Gln 
        755                 760                 765             


Gln Ser Ala Gly Phe Leu Gln Gln Leu Ser Ile Leu Asn Ser Arg Ser 
    770                 775                 780                 


Phe Lys Asn Met Tyr Arg Asn Pro Lys Leu Leu Leu Gly Asn Tyr Leu 
785                 790                 795                 800 


Leu Thr Ile Leu Leu Ser Leu Phe Leu Gly Thr Leu Tyr Tyr Asn Val 
                805                 810                 815     


Ser Asn Asp Ile Ser Gly Phe Gln Asn Arg Met Gly Leu Phe Phe Phe 
            820                 825                 830         


Ile Leu Thr Tyr Phe Gly Phe Val Thr Phe Thr Gly Leu Ser Ser Phe 
        835                 840                 845             


Ala Leu Glu Arg Ile Ile Phe Ile Lys Glu Arg Ser Asn Asn Tyr Tyr 
    850                 855                 860                 


Ser Pro Leu Ala Tyr Tyr Ile Ser Lys Ile Met Ser Glu Val Val Pro 
865                 870                 875                 880 


Leu Arg Val Val Pro Pro Ile Leu Leu Ser Leu Ile Val Tyr Pro Met 
                885                 890                 895     


Thr Gly Leu Asn Met Lys Asp Asn Ala Phe Phe Lys Cys Ile Gly Ile 
            900                 905                 910         


Leu Ile Leu Phe Asn Leu Gly Ile Ser Leu Glu Ile Leu Thr Ile Gly 
        915                 920                 925             


Ile Ile Phe Glu Asp Leu Asn Asn Ser Ile Ile Leu Ser Val Leu Val 
    930                 935                 940                 


Leu Leu Gly Ser Leu Leu Phe Ser Gly Leu Phe Ile Asn Thr Lys Asn 
945                 950                 955                 960 


Ile Thr Asn Val Ala Phe Lys Tyr Leu Lys Asn Phe Ser Val Phe Tyr 
                965                 970                 975     


Tyr Ala Tyr Glu Ser Leu Leu Ile Asn Glu Val Lys Thr Leu Met Leu 
            980                 985                 990         


Lys Glu Arg Lys Tyr Gly Leu Asn  Ile Glu Val Pro Gly  Ala Thr Ile 
        995                 1000                 1005             


Leu Ser  Thr Phe Gly Phe Val  Val Gln Asn Leu Val  Phe Asp Ile 
    1010                 1015                 1020             


Lys Ile  Leu Ala Leu Phe Asn  Val Val Phe Leu Ile  Met Gly Tyr 
    1025                 1030                 1035             


Leu Ala  Leu Lys Trp Ile Val  Val Glu Gln Lys 
    1040                 1045                 


<210>  4
<211>  610
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  4

Met Pro Pro Val Ser Ala Ser Lys Ala Lys Arg Asp Ala Lys Lys Ala 
1               5                   10                  15      


Glu Arg Glu Ala Lys Lys Ala Ala Ala Gly Lys Thr Ile Arg Lys Leu 
            20                  25                  30          


Gly Arg Lys Lys Glu Ala Ala Ala Glu Glu Ser Glu Val Asp Ala Ala 
        35                  40                  45              


Ala Arg Glu Ile Lys Met Met Lys Leu Gln Gln Asp Lys Asp Gly Leu 
    50                  55                  60                  


Ser Asp Arg Val Val Thr Gly Val Leu Ser Ser Leu Glu Thr Ser Arg 
65                  70                  75                  80  


Asp Ile Lys Leu Ser Ser Val Ser Leu Leu Phe His Gly Lys Val Leu 
                85                  90                  95      


Ile Gln Asp Ser Gly Leu Glu Leu Asn Tyr Gly Arg Arg Tyr Gly Leu 
            100                 105                 110         


Leu Gly Glu Asn Gly Cys Gly Lys Ser Thr Phe Leu Lys Ala Leu Ala 
        115                 120                 125             


Thr Arg Glu Tyr Pro Ile Pro Glu His Ile Asp Ile Tyr Leu Leu Asp 
    130                 135                 140                 


Glu Pro Ala Glu Pro Ser Glu Leu Ser Ala Leu Asp Tyr Val Val Thr 
145                 150                 155                 160 


Glu Ala Gln His Glu Leu Lys Arg Ile Glu Asp Leu Val Glu Lys Thr 
                165                 170                 175     


Ile Leu Glu Asp Gly Pro Glu Ser Glu Leu Leu Glu Pro Leu Tyr Glu 
            180                 185                 190         


Arg Met Asp Ser Leu Asp Pro Asp Thr Phe Glu Ser Arg Ala Ala Ile 
        195                 200                 205             


Ile Leu Ile Gly Leu Gly Phe Asn Lys Lys Thr Ile Leu Lys Lys Thr 
    210                 215                 220                 


Lys Asp Met Ser Gly Gly Trp Lys Met Arg Val Ala Leu Ala Lys Ala 
225                 230                 235                 240 


Leu Phe Val Lys Pro Thr Leu Leu Leu Leu Asp Asp Pro Thr Ala His 
                245                 250                 255     


Leu Asp Leu Glu Ala Cys Val Trp Leu Glu Glu Tyr Leu Lys Arg Phe 
            260                 265                 270         


Asp Arg Thr Leu Val Leu Val Ser His Ser Gln Asp Phe Leu Asn Gly 
        275                 280                 285             


Val Cys Thr Asn Met Ile Asp Met Arg Ala Gln Lys Leu Thr Ala Tyr 
    290                 295                 300                 


Gly Gly Asn Tyr Asp Ser Tyr His Lys Thr Arg Ser Glu Leu Glu Thr 
305                 310                 315                 320 


Asn Gln Met Lys Gln Tyr Asn Lys Gln Gln Glu Glu Ile Gln His Ile 
                325                 330                 335     


Lys Lys Phe Ile Ala Ser Ala Gly Thr Tyr Ala Asn Leu Val Lys Gln 
            340                 345                 350         


Ala Lys Ser Arg Gln Lys Ile Leu Asp Lys Met Glu Ala Asp Gly Leu 
        355                 360                 365             


Val Gln Pro Val Val Pro Asp Lys Val Phe Ser Phe Arg Phe Pro Gln 
    370                 375                 380                 


Val Glu Arg Leu Pro Pro Pro Val Leu Ala Phe Asp Asp Ile Ser Phe 
385                 390                 395                 400 


His Tyr Glu Ser Asn Pro Ser Glu Asn Leu Tyr Glu His Leu Asn Phe 
                405                 410                 415     


Gly Val Asp Met Asp Ser Arg Ile Ala Leu Val Gly Pro Asn Gly Val 
            420                 425                 430         


Gly Lys Ser Thr Leu Leu Lys Ile Met Thr Gly Glu Leu Thr Pro Gln 
        435                 440                 445             


Ser Gly Arg Val Ser Arg His Thr His Val Lys Leu Gly Val Tyr Ser 
    450                 455                 460                 


Gln His Ser Gln Asp Gln Leu Asp Leu Thr Lys Ser Ala Leu Glu Phe 
465                 470                 475                 480 


Val Arg Asp Lys Tyr Ser Asn Ile Ser Gln Asp Phe Gln Phe Trp Arg 
                485                 490                 495     


Gly Gln Leu Gly Arg Tyr Gly Leu Thr Gly Glu Gly Gln Thr Val Gln 
            500                 505                 510         


Met Ala Thr Leu Ser Glu Gly Gln Arg Ser Arg Val Val Phe Ala Leu 
        515                 520                 525             


Leu Ala Leu Glu Gln Pro Asn Val Leu Leu Leu Asp Glu Pro Thr Asn 
    530                 535                 540                 


Gly Leu Asp Ile Pro Thr Ile Asp Ser Leu Ala Asp Ala Ile Asn Glu 
545                 550                 555                 560 


Phe Asn Gly Gly Val Val Val Val Ser His Asp Phe Arg Leu Leu Asp 
                565                 570                 575     


Lys Ile Ala Gln Asp Ile Phe Val Val Glu Asn Lys Thr Ala Thr Arg 
            580                 585                 590         


Trp Asp Gly Ser Ile Leu Gln Tyr Lys Asn Lys Leu Ala Lys Asn Val 
        595                 600                 605             


Val Leu 
    610 


<210>  5
<211>  690
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Leu Leu Leu Pro Arg Cys Pro Val Ile Gly Arg Ile Val Arg Ser 
1               5                   10                  15      


Lys Phe Arg Ser Gly Leu Ile Arg Asn His Ser Pro Val Ile Phe Thr 
            20                  25                  30          


Val Ser Lys Leu Ser Thr Gln Arg Pro Leu Leu Phe Asn Ser Ala Val 
        35                  40                  45              


Asn Leu Trp Asn Gln Ala Gln Lys Asp Ile Thr His Lys Lys Ser Val 
    50                  55                  60                  


Glu Gln Phe Ser Ser Ala Pro Lys Val Lys Thr Gln Val Lys Lys Thr 
65                  70                  75                  80  


Ser Lys Ala Pro Thr Leu Ser Glu Leu Lys Ile Leu Lys Asp Leu Phe 
                85                  90                  95      


Arg Tyr Ile Trp Pro Lys Gly Asn Asn Lys Val Arg Ile Arg Val Leu 
            100                 105                 110         


Ile Ala Leu Gly Leu Leu Ile Ser Ala Lys Ile Leu Asn Val Gln Val 
        115                 120                 125             


Pro Phe Phe Phe Lys Gln Thr Ile Asp Ser Met Asn Ile Ala Trp Asp 
    130                 135                 140                 


Asp Pro Thr Val Ala Leu Pro Ala Ala Ile Gly Leu Thr Ile Leu Cys 
145                 150                 155                 160 


Tyr Gly Val Ala Arg Phe Gly Ser Val Leu Phe Gly Glu Leu Arg Asn 
                165                 170                 175     


Ala Val Phe Ala Lys Val Ala Gln Asn Ala Ile Arg Thr Val Ser Leu 
            180                 185                 190         


Gln Thr Phe Gln His Leu Met Lys Leu Asp Leu Gly Trp His Leu Ser 
        195                 200                 205             


Arg Gln Thr Gly Gly Leu Thr Arg Ala Met Asp Arg Gly Thr Lys Gly 
    210                 215                 220                 


Ile Ser Gln Val Leu Thr Ala Met Val Phe His Ile Ile Pro Ile Ser 
225                 230                 235                 240 


Phe Glu Ile Ser Val Val Cys Gly Ile Leu Thr Tyr Gln Phe Gly Ala 
                245                 250                 255     


Ser Phe Ala Ala Ile Thr Phe Ser Thr Met Leu Leu Tyr Ser Ile Phe 
            260                 265                 270         


Thr Ile Lys Thr Thr Ala Trp Arg Thr His Phe Arg Arg Asp Ala Asn 
        275                 280                 285             


Lys Ala Asp Asn Lys Ala Ala Ser Val Ala Leu Asp Ser Leu Ile Asn 
    290                 295                 300                 


Phe Glu Ala Val Lys Tyr Phe Asn Asn Glu Lys Tyr Leu Ala Asp Lys 
305                 310                 315                 320 


Tyr Asn Gly Ser Leu Met Asn Tyr Arg Asp Ser Gln Ile Lys Val Ser 
                325                 330                 335     


Gln Ser Leu Ala Phe Leu Asn Ser Gly Gln Asn Leu Ile Phe Thr Thr 
            340                 345                 350         


Ala Leu Thr Ala Met Met Tyr Met Gly Cys Thr Gly Val Ile Gly Gly 
        355                 360                 365             


Asn Leu Thr Val Gly Asp Leu Val Leu Ile Asn Gln Leu Val Phe Gln 
    370                 375                 380                 


Leu Ser Val Pro Leu Asn Phe Leu Gly Ser Val Tyr Arg Asp Leu Lys 
385                 390                 395                 400 


Gln Ser Leu Ile Asp Met Glu Thr Leu Phe Lys Leu Arg Lys Asn Glu 
                405                 410                 415     


Val Lys Ile Lys Asn Ala Glu Arg Pro Leu Met Leu Pro Glu Asn Val 
            420                 425                 430         


Pro Tyr Asp Ile Thr Phe Glu Asn Val Thr Phe Gly Tyr His Pro Asp 
        435                 440                 445             


Arg Lys Ile Leu Lys Asn Ala Ser Phe Thr Ile Pro Ala Gly Trp Lys 
    450                 455                 460                 


Thr Ala Ile Val Gly Ser Ser Gly Ser Gly Lys Ser Thr Ile Leu Lys 
465                 470                 475                 480 


Leu Val Phe Arg Phe Tyr Asp Pro Glu Ser Gly Arg Ile Leu Ile Asn 
                485                 490                 495     


Gly Arg Asp Ile Lys Glu Tyr Asp Ile Asp Ala Leu Arg Lys Val Ile 
            500                 505                 510         


Gly Val Val Pro Gln Asp Thr Pro Leu Phe Asn Asp Thr Ile Trp Glu 
        515                 520                 525             


Asn Val Lys Phe Gly Arg Ile Asp Ala Thr Asp Glu Glu Val Ile Thr 
    530                 535                 540                 


Val Val Glu Lys Ala Gln Leu Ala Pro Leu Ile Lys Lys Leu Pro Gln 
545                 550                 555                 560 


Gly Phe Asp Thr Ile Val Gly Glu Arg Gly Leu Met Ile Ser Gly Gly 
                565                 570                 575     


Glu Lys Gln Arg Leu Ala Ile Ala Arg Val Leu Leu Lys Asn Ala Arg 
            580                 585                 590         


Ile Met Phe Phe Asp Glu Ala Thr Ser Ala Leu Asp Thr His Thr Glu 
        595                 600                 605             


Gln Ala Leu Leu Arg Thr Ile Arg Asp Asn Phe Thr Ser Gly Ser Arg 
    610                 615                 620                 


Thr Ser Val Tyr Ile Ala His Arg Leu Arg Thr Ile Ala Asp Ala Asp 
625                 630                 635                 640 


Lys Ile Ile Val Leu Asp Asn Gly Arg Val Arg Glu Glu Gly Lys His 
                645                 650                 655     


Leu Glu Leu Leu Ala Met Pro Gly Ser Leu Tyr Arg Glu Leu Trp Thr 
            660                 665                 670         


Ile Gln Glu Asp Leu Asp His Leu Glu Asn Glu Leu Lys Asp Gln Gln 
        675                 680                 685             


Glu Leu 
    690 


<210>  6
<211>  542
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  6

Met Gly Asn Gln Ser Leu Val Val Leu Thr Glu Ser Lys Gly Glu Tyr 
1               5                   10                  15      


Glu Asn Glu Thr Glu Leu Pro Val Lys Lys Ser Ser Arg Asp Asn Asn 
            20                  25                  30          


Ile Gly Glu Ser Leu Thr Ala Thr Ala Phe Thr Gln Ser Glu Asp Glu 
        35                  40                  45              


Met Val Asp Ser Asn Gln Lys Trp Gln Asn Pro Asn Tyr Phe Lys Tyr 
    50                  55                  60                  


Ala Trp Gln Glu Tyr Leu Phe Ile Phe Thr Cys Met Ile Ser Gln Leu 
65                  70                  75                  80  


Leu Asn Gln Ala Gly Thr Thr Gln Thr Leu Ser Ile Met Asn Ile Leu 
                85                  90                  95      


Ser Asp Ser Phe Gly Ser Glu Gly Asn Ser Lys Ser Trp Leu Met Ala 
            100                 105                 110         


Ser Phe Pro Leu Val Ser Gly Ser Phe Ile Leu Ile Ser Gly Arg Leu 
        115                 120                 125             


Gly Asp Ile Tyr Gly Leu Lys Lys Met Leu Leu Val Gly Tyr Val Leu 
    130                 135                 140                 


Val Ile Ile Trp Ser Leu Ile Cys Gly Ile Thr Lys Tyr Ser Gly Ser 
145                 150                 155                 160 


Asp Thr Phe Phe Ile Ile Ser Arg Ala Phe Gln Gly Leu Gly Ile Ala 
                165                 170                 175     


Phe Val Leu Pro Asn Val Leu Gly Ile Ile Gly Asn Ile Tyr Val Gly 
            180                 185                 190         


Gly Thr Phe Arg Lys Asn Ile Val Ile Ser Phe Val Gly Ala Met Ala 
        195                 200                 205             


Pro Ile Gly Ala Thr Leu Gly Cys Leu Phe Ala Gly Leu Ile Gly Thr 
    210                 215                 220                 


Glu Asp Pro Lys Gln Trp Pro Trp Ala Phe Tyr Ala Tyr Ser Ile Ala 
225                 230                 235                 240 


Ala Phe Ile Asn Phe Val Leu Ser Ile Tyr Ala Ile Pro Ser Thr Ile 
                245                 250                 255     


Pro Thr Asn Ile His His Phe Ser Met Asp Trp Ile Gly Ser Val Leu 
            260                 265                 270         


Gly Val Ile Gly Leu Ile Leu Leu Asn Phe Val Trp Asn Gln Ala Pro 
        275                 280                 285             


Ile Ser Gly Trp Asn Gln Ala Tyr Ile Ile Val Ile Leu Ile Ile Ser 
    290                 295                 300                 


Val Ile Phe Leu Val Val Phe Ile Ile Tyr Glu Ile Arg Phe Ala Lys 
305                 310                 315                 320 


Thr Pro Leu Leu Pro Arg Ala Val Ile Lys Asp Arg His Met Ile Gln 
                325                 330                 335     


Ile Met Leu Ala Leu Phe Phe Gly Trp Gly Ser Phe Gly Ile Phe Thr 
            340                 345                 350         


Phe Tyr Tyr Phe Gln Phe Gln Leu Asn Ile Arg Gln Tyr Thr Ala Leu 
        355                 360                 365             


Trp Ala Gly Gly Thr Tyr Phe Met Phe Leu Ile Trp Gly Ile Ile Ala 
    370                 375                 380                 


Ala Leu Leu Val Gly Phe Thr Ile Lys Asn Val Ser Pro Ser Val Phe 
385                 390                 395                 400 


Leu Phe Phe Ser Met Val Ala Phe Asn Val Gly Ser Ile Met Ala Ser 
                405                 410                 415     


Val Thr Pro Val His Glu Thr Tyr Phe Arg Thr Gln Leu Gly Thr Met 
            420                 425                 430         


Ile Ile Leu Ser Phe Gly Met Asp Leu Ser Phe Pro Ala Ser Ser Ile 
        435                 440                 445             


Ile Phe Ser Asp Asn Leu Pro Met Glu Tyr Gln Gly Met Ala Gly Ser 
    450                 455                 460                 


Leu Val Asn Thr Val Val Asn Tyr Ser Met Ser Leu Cys Leu Gly Met 
465                 470                 475                 480 


Gly Ala Thr Val Glu Thr Gln Val Asn Ser Asp Gly Lys His Leu Leu 
                485                 490                 495     


Lys Gly Tyr Arg Gly Ala Gln Tyr Leu Gly Ile Gly Leu Ala Ser Leu 
            500                 505                 510         


Ala Cys Met Ile Ser Gly Leu Tyr Met Val Glu Ser Phe Ile Lys Gly 
        515                 520                 525             


Arg Arg Ala Arg Ala Ala Ala Glu Tyr Asp Cys Thr Val Ala 
    530                 535                 540         


<210>  7
<211>  1394
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Ser Ile Ser Lys Tyr Phe Thr Pro Val Ala Asp Gly Ser Leu Thr 
1               5                   10                  15      


Phe Asn Gly Ala Asn Ile Gln Phe Gly Ala Asp Ala Gln Gly Glu Ser 
            20                  25                  30          


Lys Lys Ser Tyr Asp Ala Glu Asp Ser Met Pro Asn Pro Ala Asn Gln 
        35                  40                  45              


Leu Asn Asp Ile Thr Phe Gln Ala Glu Ala Gly Glu Met Val Leu Val 
    50                  55                  60                  


Leu Gly Tyr Pro Thr Ser Thr Leu Phe Lys Thr Leu Phe His Gly Lys 
65                  70                  75                  80  


Thr Ser Leu Ser Tyr Ser Pro Pro Gly Ser Ile Lys Phe Lys Asn Asn 
                85                  90                  95      


Glu Phe Lys Ser Phe Ser Glu Lys Cys Pro His Gln Ile Ile Tyr Asn 
            100                 105                 110         


Asn Glu Gln Asp Val His Phe Pro Phe Leu Thr Val Glu Gln Thr Ile 
        115                 120                 125             


Asp Phe Ala Leu Ser Cys Lys Phe Asp Ile Pro Lys Gly Glu Arg Asp 
    130                 135                 140                 


Gln Ile Arg Asn Glu Leu Leu Arg Glu Phe Gly Leu Ser His Val Leu 
145                 150                 155                 160 


Lys Thr Ile Val Gly Asn Asp Phe Phe Arg Gly Val Ser Gly Gly Glu 
                165                 170                 175     


Arg Lys Arg Ile Ser Ile Ile Glu Thr Phe Ile Ala Asn Gly Ser Val 
            180                 185                 190         


Tyr Leu Trp Asp Asn Ser Thr Lys Gly Leu Asp Ser Ala Thr Ala Leu 
        195                 200                 205             


Asp Phe Leu Glu Ile Leu Arg Lys Met Ala Lys Ala Thr Arg Ser Val 
    210                 215                 220                 


Asn Leu Val Arg Ile Ser Gln Ala Ser Asp Lys Ile Val Asp Lys Phe 
225                 230                 235                 240 


Asp Lys Ile Leu Met Leu Ser Asp Ser Tyr Gln Leu Phe Tyr Gly Thr 
                245                 250                 255     


Val Asp Glu Cys Leu Thr Tyr Phe Arg Asp Thr Leu Gly Ile Glu Lys 
            260                 265                 270         


Asp Pro Asn Asp Cys Ile Ile Glu Tyr Leu Thr Ser Ile Leu Asn Phe 
        275                 280                 285             


Gln Phe Lys Asn Lys Asn Leu Gly Asn Leu Ser Asn Ser Ser Ser Ala 
    290                 295                 300                 


Ser Val Leu Lys Thr Ala Thr Gly Glu Val Thr Lys Tyr Thr Tyr Asn 
305                 310                 315                 320 


Ser Asp Phe Asp Leu Tyr Asp Gln Trp Lys His Ser Ser Tyr Tyr Arg 
                325                 330                 335     


Asn Ile Lys Gln Gln Ile Gln Gly Ser Ser Ile Asp Asp Ser Ile Lys 
            340                 345                 350         


Glu Val Asp Pro Ser Asp Val Ser Pro Ile Phe Asn Ile Pro Leu Lys 
        355                 360                 365             


Lys Gln Leu Leu Phe Cys Thr Lys Arg Ala Phe Gln Arg Ser Leu Gly 
    370                 375                 380                 


Asp Lys Ala Tyr Met Thr Ala Gln Phe Ile Ser Val Val Ile Gln Ser 
385                 390                 395                 400 


Leu Val Ile Gly Ser Leu Phe Tyr Glu Ile Pro Leu Thr Thr Ile Gly 
                405                 410                 415     


Ser Tyr Ser Arg Gly Ser Leu Thr Phe Phe Ser Ile Leu Phe Phe Thr 
            420                 425                 430         


Phe Leu Ser Leu Ala Asp Met Pro Ile Ala Phe Gln Arg Gln Pro Val 
        435                 440                 445             


Val Lys Lys Gln Ser Gln Leu His Phe Tyr Thr Asn Trp Val Glu Thr 
    450                 455                 460                 


Leu Ser Thr Thr Val Phe Asp Tyr Cys Phe Lys Leu Cys Leu Val Ile 
465                 470                 475                 480 


Val Phe Ser Ile Ile Leu Tyr Phe Leu Ala His Leu Gln Tyr Lys Ala 
                485                 490                 495     


Ala Arg Phe Phe Ile Phe Leu Leu Phe Leu Ser Phe Tyr Asn Phe Cys 
            500                 505                 510         


Met Val Ser Leu Phe Ala Leu Thr Thr Leu Val Ala Pro Thr Ile Ser 
        515                 520                 525             


Val Ala Asn Leu Phe Ala Gly Ile Leu Leu Leu Ala Ile Ala Met Tyr 
    530                 535                 540                 


Ala Ser Tyr Val Ile Tyr Leu Lys Asn Met His Pro Trp Phe Val Trp 
545                 550                 555                 560 


Ile Ala Tyr Leu Asn Pro Ala Met Tyr Ala Met Glu Ala Ile Leu Ser 
                565                 570                 575     


Asn Glu Leu Tyr Asn Leu Lys Leu Asp Cys Ser Glu Thr Ile Val Pro 
            580                 585                 590         


Arg Gly Pro Thr Tyr Asn Asp Val Pro Phe Ser His Lys Ala Cys Ala 
        595                 600                 605             


Trp Gln Gly Ala Thr Leu Gly Asn Asp Tyr Val Arg Gly Arg Asp Tyr 
    610                 615                 620                 


Leu Lys Gln Gly Leu Ser Tyr Thr Tyr His His Val Trp Arg Asn Phe 
625                 630                 635                 640 


Gly Ile Ile Ile Gly Phe Leu Val Phe Phe Ile Ala Cys Thr Leu Phe 
                645                 650                 655     


Ala Ser Gln Tyr Ile Lys Pro Tyr Phe Asn Lys Asp Glu Ile Glu Arg 
            660                 665                 670         


Asn Asn Ser Arg Leu Thr Arg Trp Leu Pro Phe Leu Asn Lys Lys Arg 
        675                 680                 685             


Gly Thr Arg Ser Ser Ala Arg Asn Asp Ser Lys Tyr Val Gly Ile Pro 
    690                 695                 700                 


Lys Ser His Ser Val Ser Ser Ser Ser Ser Ser Leu Ser Ala Val Pro 
705                 710                 715                 720 


Tyr Gln Ile Ser Pro Ser Asn Lys Glu Met Ala Leu Asn Asp Tyr Asn 
                725                 730                 735     


Glu Gln Pro Ile Thr Glu Thr Val Glu Thr Gln Lys His Ile Ile Ser 
            740                 745                 750         


Trp Lys Asn Ile Asn Tyr Thr Val Gly Thr Lys Lys Leu Ile Asn Asn 
        755                 760                 765             


Ala Ser Gly Phe Ile Ser Ser Gly Leu Thr Ala Leu Met Gly Glu Ser 
    770                 775                 780                 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ser Gln Arg Val Glu 
785                 790                 795                 800 


Thr Gly Val Val Ser Gly Glu Ile Leu Ile Asp Gly His Pro Leu Thr 
                805                 810                 815     


Asp Glu Asp Ala Phe Lys Arg Ser Ile Gly Phe Val Gln Gln Gln Asp 
            820                 825                 830         


Leu His Leu Asp Leu Leu Ser Val Lys Glu Ser Leu Glu Ile Ser Cys 
        835                 840                 845             


Leu Leu Arg Gly Asp Gly Asp Arg Ala Tyr Leu Asp Thr Val Ser Asn 
    850                 855                 860                 


Leu Leu Lys Leu Pro Ser Asp Ile Leu Val Ala Asp Leu Asn Pro Thr 
865                 870                 875                 880 


Gln Arg Lys Leu Leu Ser Ile Gly Val Glu Leu Val Thr Lys Pro Ser 
                885                 890                 895     


Leu Leu Leu Phe Leu Asp Glu Pro Thr Ser Gly Leu Asp Ala Glu Ala 
            900                 905                 910         


Ala Leu Thr Ile Val Lys Phe Leu Lys Gln Leu Ser Leu Gln Gly Gln 
        915                 920                 925             


Ala Ile Phe Cys Thr Ile His Gln Pro Ser Lys Ser Val Ile Ser His 
    930                 935                 940                 


Phe Asp Asn Ile Phe Leu Leu Lys Arg Gly Gly Glu Cys Val Phe Phe 
945                 950                 955                 960 


Gly Pro Met Asp Asp Ala Cys Gly Tyr Phe Met Ser His Asp Asn Thr 
                965                 970                 975     


Leu Val Tyr Asp Lys Glu His Asp Asn Pro Ala Asp Phe Val Ile Asp 
            980                 985                 990         


Ala Val Gly Asn Ser Asn Ser Ser  Ala Gly Lys Asp Thr  Ala Glu Glu 
        995                 1000                 1005             


Ala Leu  Thr Leu Asn Lys Glu  Ala Ile Asp Trp Ser  Ala Leu Trp 
    1010                 1015                 1020             


Glu Ser  Ser Val Glu Lys Lys  Leu Val Lys Lys Glu  Thr Ala Arg 
    1025                 1030                 1035             


Leu Glu  Asp Asp Ala Arg Ala  Ser Gly Val Asp Tyr  Thr Thr Ser 
    1040                 1045                 1050             


Leu Trp  Lys Gln Pro Ser Tyr  Leu Gln Gln Leu Ala  Leu Ile Thr 
    1055                 1060                 1065             


Arg Arg  Gln Tyr Ile Cys Thr  Lys Arg Asp Met Thr  Tyr Val Met 
    1070                 1075                 1080             


Ala Lys  Tyr Cys Leu Asn Gly  Gly Ala Gly Leu Phe  Ile Gly Phe 
    1085                 1090                 1095             


Ser Phe  Trp His Ile Lys His  Asn Ile Ile Gly Leu  Gln Asp Ser 
    1100                 1105                 1110             


Ile Phe  Phe Cys Phe Met Ala  Leu Cys Val Ser Ser  Pro Leu Ile 
    1115                 1120                 1125             


Asn Gln  Ile Gln Asp Lys Ala  Leu Lys Thr Lys Glu  Val Tyr Val 
    1130                 1135                 1140             


Ala Arg  Glu Ala Arg Ser Asn  Thr Tyr His Trp Thr  Val Leu Leu 
    1145                 1150                 1155             


Leu Ser  Gln Ser Ile Ile Glu  Leu Pro Leu Ala Leu  Thr Ser Ser 
    1160                 1165                 1170             


Thr Leu  Phe Phe Val Cys Ala  Phe Phe Ser Cys Gly  Phe Asn Asn 
    1175                 1180                 1185             


Ala Gly  Trp Ser Ala Gly Val  Phe Phe Leu Asn Tyr  Met Leu Phe 
    1190                 1195                 1200             


Ala Ala  Tyr Tyr Ser Thr Leu  Gly Leu Trp Leu Ile  Tyr Thr Ala 
    1205                 1210                 1215             


Pro Asn  Leu Gln Thr Ala Ala  Val Phe Val Ala Phe  Ile Tyr Ser 
    1220                 1225                 1230             


Phe Thr  Ala Ser Phe Cys Gly  Val Met Gln Pro Tyr  Ser Leu Phe 
    1235                 1240                 1245             


Pro Thr  Phe Trp Lys Phe Met  Tyr Arg Val Ser Pro  Tyr Thr Tyr 
    1250                 1255                 1260             


Phe Val  Glu Thr Phe Val Ser  Ile Leu Leu His Asn  Trp Glu Ile 
    1265                 1270                 1275             


Lys Cys  Asp Met Ser Glu Met  Val Pro Gly Gln Pro  Leu Thr Gly 
    1280                 1285                 1290             


Gln Ser  Cys Gly Gln Phe Met  Glu Ala Phe Ile Glu  Glu Tyr Gly 
    1295                 1300                 1305             


Gly Tyr  Leu His Asn Lys Asn  Thr Phe Thr Val Cys  Ala Tyr Cys 
    1310                 1315                 1320             


Thr Tyr  Thr Val Gly Asp Asp  Phe Leu Lys Asn Glu  Asn Met Ser 
    1325                 1330                 1335             


Tyr Asp  His Val Trp Arg Asn  Phe Gly Ile Glu Trp  Ala Phe Val 
    1340                 1345                 1350             


Gly Phe  Asn Phe Phe Ala Met  Phe Ala Gly Tyr Tyr  Leu Thr Tyr 
    1355                 1360                 1365             


Val Ala  Arg Ile Trp Pro Lys  Val Phe Lys Ile Ile  Thr Lys Val 
    1370                 1375                 1380             


Ile Pro  His Arg Gly Lys Lys  Pro Val Gln Asn 
    1385                 1390                 


<210>  8
<211>  1559
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  8

Met Ser Ser Leu Glu Val Val Asp Gly Cys Pro Tyr Gly Tyr Arg Pro 
1               5                   10                  15      


Tyr Pro Asp Ser Gly Thr Asn Ala Leu Asn Pro Cys Phe Ile Ser Val 
            20                  25                  30          


Ile Ser Ala Trp Gln Ala Val Phe Phe Leu Leu Ile Gly Ser Tyr Gln 
        35                  40                  45              


Leu Trp Lys Leu Tyr Lys Asn Asn Lys Val Pro Pro Arg Phe Lys Asn 
    50                  55                  60                  


Phe Pro Thr Leu Pro Ser Lys Ile Asn Ser Arg His Leu Thr His Leu 
65                  70                  75                  80  


Thr Asn Val Cys Phe Gln Ser Thr Leu Ile Ile Cys Glu Leu Ala Leu 
                85                  90                  95      


Val Ser Gln Ser Ser Asp Arg Val Tyr Pro Phe Ile Leu Lys Lys Ala 
            100                 105                 110         


Leu Tyr Leu Asn Leu Leu Phe Asn Leu Gly Ile Ser Leu Pro Thr Gln 
        115                 120                 125             


Tyr Leu Ala Tyr Phe Lys Ser Thr Phe Ser Met Gly Asn Gln Leu Phe 
    130                 135                 140                 


Tyr Tyr Met Phe Gln Ile Leu Leu Gln Leu Phe Leu Ile Leu Gln Arg 
145                 150                 155                 160 


Tyr Tyr His Gly Ser Ser Asn Glu Arg Leu Thr Val Ile Ser Gly Gln 
                165                 170                 175     


Thr Ala Met Ile Leu Glu Val Leu Leu Leu Phe Asn Ser Val Ala Ile 
            180                 185                 190         


Phe Ile Tyr Asp Leu Cys Ile Phe Glu Pro Ile Asn Glu Leu Ser Glu 
        195                 200                 205             


Tyr Tyr Lys Lys Asn Gly Trp Tyr Pro Pro Val His Val Leu Ser Tyr 
    210                 215                 220                 


Ile Thr Phe Ile Trp Met Asn Lys Leu Ile Val Glu Thr Tyr Arg Asn 
225                 230                 235                 240 


Lys Lys Ile Lys Asp Pro Asn Gln Leu Pro Leu Pro Pro Val Asp Leu 
                245                 250                 255     


Asn Ile Lys Ser Ile Ser Lys Glu Phe Lys Ala Asn Trp Glu Leu Glu 
            260                 265                 270         


Lys Trp Leu Asn Arg Asn Ser Leu Trp Arg Ala Ile Trp Lys Ser Phe 
        275                 280                 285             


Gly Arg Thr Ile Ser Val Ala Met Leu Tyr Glu Thr Thr Ser Asp Leu 
    290                 295                 300                 


Leu Ser Val Val Gln Pro Gln Phe Leu Arg Ile Phe Ile Asp Gly Leu 
305                 310                 315                 320 


Asn Pro Glu Thr Ser Ser Lys Tyr Pro Pro Leu Asn Gly Val Phe Ile 
                325                 330                 335     


Ala Leu Thr Leu Phe Val Ile Ser Val Val Ser Val Phe Leu Thr Asn 
            340                 345                 350         


Gln Phe Tyr Ile Gly Ile Phe Glu Ala Gly Leu Gly Ile Arg Gly Ser 
        355                 360                 365             


Leu Ala Ser Leu Val Tyr Gln Lys Ser Leu Arg Leu Thr Leu Ala Glu 
    370                 375                 380                 


Arg Asn Glu Lys Ser Thr Gly Asp Ile Leu Asn Leu Met Ser Val Asp 
385                 390                 395                 400 


Val Leu Arg Ile Gln Arg Phe Phe Glu Asn Ala Gln Thr Ile Ile Gly 
                405                 410                 415     


Ala Pro Ile Gln Ile Ile Val Val Leu Thr Ser Leu Tyr Trp Leu Leu 
            420                 425                 430         


Gly Lys Ala Val Ile Gly Gly Leu Val Thr Met Ala Ile Met Met Pro 
        435                 440                 445             


Ile Asn Ala Phe Leu Ser Arg Lys Val Lys Lys Leu Ser Lys Thr Gln 
    450                 455                 460                 


Met Lys Tyr Lys Asp Met Arg Ile Lys Thr Ile Thr Glu Leu Leu Asn 
465                 470                 475                 480 


Ala Ile Lys Ser Ile Lys Leu Tyr Ala Trp Glu Glu Pro Met Met Ala 
                485                 490                 495     


Arg Leu Asn His Val Arg Asn Asp Met Glu Leu Lys Asn Phe Arg Lys 
            500                 505                 510         


Ile Gly Ile Val Ser Asn Leu Ile Tyr Phe Ala Trp Asn Cys Val Pro 
        515                 520                 525             


Leu Met Val Thr Cys Ser Thr Phe Gly Leu Phe Ser Leu Phe Ser Asp 
    530                 535                 540                 


Ser Pro Leu Ser Pro Ala Ile Val Phe Pro Ser Leu Ser Leu Phe Asn 
545                 550                 555                 560 


Ile Leu Asn Ser Ala Ile Tyr Ser Val Pro Ser Met Ile Asn Thr Ile 
                565                 570                 575     


Ile Glu Thr Ser Val Ser Met Glu Arg Leu Lys Ser Phe Leu Leu Ser 
            580                 585                 590         


Asp Glu Ile Asp Asp Ser Phe Ile Glu Arg Ile Asp Pro Ser Ala Asp 
        595                 600                 605             


Glu Arg Ala Leu Pro Ala Ile Glu Met Asn Asn Ile Thr Phe Leu Trp 
    610                 615                 620                 


Lys Ser Lys Glu Val Leu Thr Ser Ser Gln Ser Gly Asp Asn Leu Arg 
625                 630                 635                 640 


Thr Asp Glu Glu Ser Ile Ile Gly Ser Ser Gln Ile Ala Leu Lys Asn 
                645                 650                 655     


Ile Asp His Phe Glu Ala Lys Arg Gly Asp Leu Val Cys Val Val Gly 
            660                 665                 670         


Arg Val Gly Ala Gly Lys Ser Thr Phe Leu Lys Ala Ile Leu Gly Gln 
        675                 680                 685             


Leu Pro Cys Met Ser Gly Ser Arg Asp Ser Ile Pro Pro Lys Leu Ile 
    690                 695                 700                 


Ile Arg Ser Ser Ser Val Ala Tyr Cys Ser Gln Glu Ser Trp Ile Met 
705                 710                 715                 720 


Asn Ala Ser Val Arg Glu Asn Ile Leu Phe Gly His Lys Phe Asp Gln 
                725                 730                 735     


Asp Tyr Tyr Asp Leu Thr Ile Lys Ala Cys Gln Leu Leu Pro Asp Leu 
            740                 745                 750         


Lys Ile Leu Pro Asp Gly Asp Glu Thr Leu Val Gly Glu Lys Gly Ile 
        755                 760                 765             


Ser Leu Ser Gly Gly Gln Lys Ala Arg Leu Ser Leu Ala Arg Ala Val 
    770                 775                 780                 


Tyr Ser Arg Ala Asp Ile Tyr Leu Leu Asp Asp Ile Leu Ser Ala Val 
785                 790                 795                 800 


Asp Ala Glu Val Ser Lys Asn Ile Ile Glu Tyr Val Leu Ile Gly Lys 
                805                 810                 815     


Thr Ala Leu Leu Lys Asn Lys Thr Ile Ile Leu Thr Thr Asn Thr Val 
            820                 825                 830         


Ser Ile Leu Lys His Ser Gln Met Ile Tyr Ala Leu Glu Asn Gly Glu 
        835                 840                 845             


Ile Val Glu Gln Gly Asn Tyr Glu Asp Val Met Asn Arg Lys Asn Asn 
    850                 855                 860                 


Thr Ser Lys Leu Lys Lys Leu Leu Glu Glu Phe Asp Ser Pro Ile Asp 
865                 870                 875                 880 


Asn Gly Asn Glu Ser Asp Val Gln Thr Glu His Arg Ser Glu Ser Glu 
                885                 890                 895     


Val Asp Glu Pro Leu Gln Leu Lys Val Thr Glu Ser Glu Thr Glu Asp 
            900                 905                 910         


Glu Val Val Thr Glu Ser Glu Leu Glu Leu Ile Lys Ala Asn Ser Arg 
        915                 920                 925             


Arg Ala Ser Leu Ala Thr Leu Arg Pro Arg Pro Phe Val Gly Ala Gln 
    930                 935                 940                 


Leu Asp Ser Val Lys Lys Thr Ala Gln Lys Ala Glu Lys Thr Glu Val 
945                 950                 955                 960 


Gly Arg Val Lys Thr Lys Ile Tyr Leu Ala Tyr Ile Lys Ala Cys Gly 
                965                 970                 975     


Val Leu Gly Val Val Leu Phe Phe Leu Phe Met Ile Leu Thr Arg Val 
            980                 985                 990         


Phe Asp Leu Ala Glu Asn Phe Trp  Leu Lys Tyr Trp Ser  Glu Ser Asn 
        995                 1000                 1005             


Glu Lys  Asn Gly Ser Asn Glu  Arg Val Trp Met Phe  Val Gly Val 
    1010                 1015                 1020             


Tyr Ser  Leu Ile Gly Val Ala  Ser Ala Ala Phe Asn  Asn Leu Arg 
    1025                 1030                 1035             


Ser Ile  Met Met Leu Leu Tyr  Cys Ser Ile Arg Gly  Ser Lys Lys 
    1040                 1045                 1050             


Leu His  Glu Ser Met Ala Lys  Ser Val Ile Arg Ser  Pro Met Thr 
    1055                 1060                 1065             


Phe Phe  Glu Thr Thr Pro Val  Gly Arg Ile Ile Asn  Arg Phe Ser 
    1070                 1075                 1080             


Ser Asp  Met Asp Ala Val Asp  Ser Asn Leu Gln Tyr  Ile Phe Ser 
    1085                 1090                 1095             


Phe Phe  Phe Lys Ser Ile Leu  Thr Tyr Leu Val Thr  Val Ile Leu 
    1100                 1105                 1110             


Val Gly  Tyr Asn Met Pro Trp  Phe Leu Val Phe Asn  Met Phe Leu 
    1115                 1120                 1125             


Val Val  Ile Tyr Ile Tyr Tyr  Gln Thr Phe Tyr Ile  Val Leu Ser 
    1130                 1135                 1140             


Arg Glu  Leu Lys Arg Leu Ile  Ser Ile Ser Tyr Ser  Pro Ile Met 
    1145                 1150                 1155             


Ser Leu  Met Ser Glu Ser Leu  Asn Gly Tyr Ser Ile  Ile Asp Ala 
    1160                 1165                 1170             


Tyr Asp  His Phe Glu Arg Phe  Ile Tyr Leu Asn Tyr  Glu Lys Ile 
    1175                 1180                 1185             


Gln Tyr  Asn Val Asp Phe Val  Phe Asn Phe Arg Ser  Thr Asn Arg 
    1190                 1195                 1200             


Trp Leu  Ser Val Arg Leu Gln  Thr Ile Gly Ala Thr  Ile Val Leu 
    1205                 1210                 1215             


Ala Thr  Ala Ile Leu Ala Leu  Ala Thr Met Asn Thr  Lys Arg Gln 
    1220                 1225                 1230             


Leu Ser  Ser Gly Met Val Gly  Leu Leu Met Ser Tyr  Ser Leu Glu 
    1235                 1240                 1245             


Val Thr  Gly Ser Leu Thr Trp  Ile Val Arg Thr Thr  Val Thr Ile 
    1250                 1255                 1260             


Glu Thr  Asn Ile Val Ser Val  Glu Arg Ile Val Glu  Tyr Cys Glu 
    1265                 1270                 1275             


Leu Pro  Pro Glu Ala Gln Ser  Ile Asn Pro Glu Lys  Arg Pro Asp 
    1280                 1285                 1290             


Glu Asn  Trp Pro Ser Lys Gly  Gly Ile Glu Phe Lys  Asn Tyr Ser 
    1295                 1300                 1305             


Thr Lys  Tyr Arg Glu Asn Leu  Asp Pro Val Leu Asn  Asn Ile Asn 
    1310                 1315                 1320             


Val Lys  Ile Glu Pro Cys Glu  Lys Val Gly Ile Val  Gly Arg Thr 
    1325                 1330                 1335             


Gly Ala  Gly Lys Ser Thr Leu  Ser Leu Ala Leu Phe  Arg Ile Leu 
    1340                 1345                 1350             


Glu Pro  Thr Glu Gly Lys Ile  Ile Ile Asp Gly Ile  Asp Ile Ser 
    1355                 1360                 1365             


Asp Ile  Gly Leu Phe Asp Leu  Arg Ser His Leu Ala  Ile Ile Pro 
    1370                 1375                 1380             


Gln Asp  Ala Gln Ala Phe Glu  Gly Thr Val Lys Thr  Asn Leu Asp 
    1385                 1390                 1395             


Pro Phe  Asn Arg Tyr Ser Glu  Asp Glu Leu Lys Arg  Ala Val Glu 
    1400                 1405                 1410             


Gln Ala  His Leu Lys Pro His  Leu Glu Lys Met Leu  His Ser Lys 
    1415                 1420                 1425             


Pro Arg  Gly Asp Asp Ser Asn  Glu Glu Asp Gly Asn  Val Asn Asp 
    1430                 1435                 1440             


Ile Leu  Asp Val Lys Ile Asn  Glu Asn Gly Ser Asn  Leu Ser Val 
    1445                 1450                 1455             


Gly Gln  Arg Gln Leu Leu Cys  Leu Ala Arg Ala Leu  Leu Asn Arg 
    1460                 1465                 1470             


Ser Lys  Ile Leu Val Leu Asp  Glu Ala Thr Ala Ser  Val Asp Met 
    1475                 1480                 1485             


Glu Thr  Asp Lys Ile Ile Gln  Asp Thr Ile Arg Arg  Glu Phe Lys 
    1490                 1495                 1500             


Asp Arg  Thr Ile Leu Thr Ile  Ala His Arg Ile Asp  Thr Val Leu 
    1505                 1510                 1515             


Asp Ser  Asp Lys Ile Ile Val  Leu Asp Gln Gly Ser  Val Arg Glu 
    1520                 1525                 1530             


Phe Asp  Ser Pro Ser Lys Leu  Leu Ser Asp Lys Thr  Ser Ile Phe 
    1535                 1540                 1545             


Tyr Ser  Leu Cys Glu Lys Gly  Gly Tyr Leu Lys 
    1550                 1555                 


<210>  9
<211>  606
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Leu Glu Thr Asp His Ser Arg Asn Asp Asn Leu Asp Asp Lys Ser 
1               5                   10                  15      


Thr Val Cys Tyr Ser Glu Lys Thr Asp Ser Asn Val Glu Lys Ser Thr 
            20                  25                  30          


Thr Ser Gly Leu Arg Arg Ile Asp Ala Val Asn Lys Val Leu Ser Asp 
        35                  40                  45              


Tyr Ser Ser Phe Thr Ala Phe Gly Val Thr Phe Ser Ser Leu Lys Thr 
    50                  55                  60                  


Ala Leu Leu Val Ala Leu Phe Leu Gln Gly Tyr Cys Thr Gly Leu Gly 
65                  70                  75                  80  


Gly Gln Ile Ser Gln Ser Ile Gln Thr Tyr Ala Ala Asn Ser Phe Gly 
                85                  90                  95      


Lys His Ser Gln Val Gly Ser Ile Asn Thr Val Lys Ser Ile Val Ala 
            100                 105                 110         


Ser Val Val Ala Val Pro Tyr Ala Arg Ile Ser Asp Arg Phe Gly Arg 
        115                 120                 125             


Ile Glu Cys Trp Ile Phe Ala Leu Val Leu Tyr Thr Ile Gly Glu Ile 
    130                 135                 140                 


Ile Ser Ala Ala Thr Pro Thr Phe Ser Gly Leu Phe Ala Gly Ile Val 
145                 150                 155                 160 


Ile Gln Gln Phe Gly Tyr Ser Gly Phe Arg Leu Leu Ala Thr Ala Leu 
                165                 170                 175     


Thr Gly Asp Leu Ser Gly Leu Arg Asp Arg Thr Phe Ala Met Asn Ile 
            180                 185                 190         


Phe Leu Ile Pro Val Ile Ile Asn Thr Trp Val Ser Gly Asn Ile Val 
        195                 200                 205             


Ser Ser Val Ala Gly Asn Val Ala Pro Tyr Lys Trp Arg Trp Gly Tyr 
    210                 215                 220                 


Gly Ile Phe Cys Ile Ile Val Pro Ile Ser Thr Leu Ile Leu Val Leu 
225                 230                 235                 240 


Pro Tyr Val Tyr Ala Gln Tyr Ile Ser Trp Arg Ser Gly Lys Leu Pro 
                245                 250                 255     


Pro Leu Lys Leu Lys Glu Lys Gly Gln Thr Leu Arg Gln Thr Leu Trp 
            260                 265                 270         


Lys Phe Ala Asp Asp Ile Asn Leu Ile Gly Val Ile Leu Phe Thr Ala 
        275                 280                 285             


Phe Leu Val Leu Val Leu Leu Pro Leu Thr Ile Ala Gly Gly Ala Thr 
    290                 295                 300                 


Ser Lys Trp Arg Glu Gly His Ile Ile Ala Met Ile Val Val Gly Gly 
305                 310                 315                 320 


Cys Leu Gly Phe Ile Phe Leu Ile Trp Glu Leu Lys Phe Ala Lys Asn 
                325                 330                 335     


Pro Phe Ile Pro Arg Val Tyr Leu Gly Asp Pro Thr Ile Tyr Val Ala 
            340                 345                 350         


Leu Leu Met Glu Phe Val Trp Arg Leu Gly Leu Gln Ile Glu Leu Glu 
        355                 360                 365             


Tyr Leu Val Thr Val Leu Met Val Ala Phe Gly Glu Ser Thr Leu Ser 
    370                 375                 380                 


Ala Gln Arg Ile Ala Gln Leu Tyr Asn Phe Leu Gln Ser Cys Thr Asn 
385                 390                 395                 400 


Ile Val Val Gly Ile Met Leu His Phe Tyr Pro His Pro Lys Val Phe 
                405                 410                 415     


Val Val Ala Gly Ser Leu Leu Gly Val Ile Gly Met Gly Leu Leu Tyr 
            420                 425                 430         


Lys Tyr Arg Val Val Tyr Asp Gly Ile Ser Gly Leu Ile Gly Ala Glu 
        435                 440                 445             


Ile Val Val Gly Ile Ala Gly Gly Met Ile Arg Phe Pro Met Trp Thr 
    450                 455                 460                 


Leu Val His Ala Ser Thr Thr His Asn Glu Met Ala Thr Val Thr Gly 
465                 470                 475                 480 


Leu Leu Met Ser Val Tyr Gln Ile Gly Asp Ala Val Gly Ala Ser Ile 
                485                 490                 495     


Ala Gly Ala Ile Trp Thr Gln Arg Leu Ala Lys Glu Leu Ile Gln Arg 
            500                 505                 510         


Leu Gly Ser Ser Leu Gly Met Ala Ile Tyr Lys Ser Pro Leu Asn Tyr 
        515                 520                 525             


Leu Lys Lys Tyr Pro Ile Gly Ser Glu Val Arg Val Gln Met Ile Glu 
    530                 535                 540                 


Ser Tyr Ser Lys Ile Gln Arg Leu Leu Ile Ile Val Ser Ile Ser Phe 
545                 550                 555                 560 


Ala Ala Phe Asn Ala Val Leu Cys Phe Phe Leu Arg Gly Phe Thr Val 
                565                 570                 575     


Asn Lys Lys Gln Ser Leu Ser Ala Glu Glu Arg Glu Lys Glu Lys Leu 
            580                 585                 590         


Lys Ile Lys Gln Gln Ser Trp Leu Arg Arg Val Ile Gly Tyr 
        595                 600                 605     


<210>  10
<211>  695
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  10

Met Ile Val Arg Met Ile Arg Leu Cys Lys Gly Pro Lys Leu Leu Arg 
1               5                   10                  15      


Ser Gln Phe Ala Ser Ala Ser Ala Leu Tyr Ser Thr Lys Ser Leu Phe 
            20                  25                  30          


Lys Pro Pro Met Tyr Gln Lys Ala Glu Ile Asn Leu Ile Ile Pro His 
        35                  40                  45              


Arg Lys His Phe Leu Leu Arg Ser Ile Arg Leu Gln Ser Asp Ile Ala 
    50                  55                  60                  


Gln Gly Lys Lys Ser Thr Lys Pro Thr Leu Lys Leu Ser Asn Ala Asn 
65                  70                  75                  80  


Ser Lys Ser Ser Gly Phe Lys Asp Ile Lys Arg Leu Phe Val Leu Ser 
                85                  90                  95      


Lys Pro Glu Ser Lys Tyr Ile Gly Leu Ala Leu Leu Leu Ile Leu Ile 
            100                 105                 110         


Ser Ser Ser Val Ser Met Ala Val Pro Ser Val Ile Gly Lys Leu Leu 
        115                 120                 125             


Asp Leu Ala Ser Glu Ser Asp Gly Glu Asp Glu Glu Gly Ser Lys Ser 
    130                 135                 140                 


Asn Lys Leu Tyr Gly Phe Thr Lys Lys Gln Phe Phe Thr Ala Leu Gly 
145                 150                 155                 160 


Ala Val Phe Ile Ile Gly Ala Val Ala Asn Ala Ser Arg Ile Ile Ile 
                165                 170                 175     


Leu Lys Val Thr Gly Glu Arg Leu Val Ala Arg Leu Arg Thr Arg Thr 
            180                 185                 190         


Met Lys Ala Ala Leu Asp Gln Asp Ala Thr Phe Leu Asp Thr Asn Arg 
        195                 200                 205             


Val Gly Asp Leu Ile Ser Arg Leu Ser Ser Asp Ala Ser Ile Val Ala 
    210                 215                 220                 


Lys Ser Val Thr Gln Asn Val Ser Asp Gly Thr Arg Ala Ile Ile Gln 
225                 230                 235                 240 


Gly Phe Val Gly Phe Gly Met Met Ser Phe Leu Ser Trp Lys Leu Thr 
                245                 250                 255     


Cys Val Met Met Ile Leu Ala Pro Pro Leu Gly Ala Met Ala Leu Ile 
            260                 265                 270         


Tyr Gly Arg Lys Ile Arg Asn Leu Ser Arg Gln Leu Gln Thr Ser Val 
        275                 280                 285             


Gly Gly Leu Thr Lys Val Ala Glu Glu Gln Leu Asn Ala Thr Arg Thr 
    290                 295                 300                 


Ile Gln Ala Tyr Gly Gly Glu Lys Asn Glu Val Arg Arg Tyr Ala Lys 
305                 310                 315                 320 


Glu Val Arg Asn Val Phe His Ile Gly Leu Lys Glu Ala Val Thr Ser 
                325                 330                 335     


Gly Leu Phe Phe Gly Ser Thr Gly Leu Val Gly Asn Thr Ala Met Leu 
            340                 345                 350         


Ser Leu Leu Leu Val Gly Thr Ser Met Ile Gln Ser Gly Ser Met Thr 
        355                 360                 365             


Val Gly Glu Leu Ser Ser Phe Met Met Tyr Ala Val Tyr Thr Gly Ser 
    370                 375                 380                 


Ser Leu Phe Gly Leu Ser Ser Phe Tyr Ser Glu Leu Met Lys Gly Ala 
385                 390                 395                 400 


Gly Ala Ala Ala Arg Val Phe Glu Leu Asn Asp Arg Lys Pro Leu Ile 
                405                 410                 415     


Arg Pro Thr Ile Gly Lys Asp Pro Val Ser Leu Ala Gln Lys Pro Ile 
            420                 425                 430         


Val Phe Lys Asn Val Ser Phe Thr Tyr Pro Thr Arg Pro Lys His Gln 
        435                 440                 445             


Ile Phe Lys Asp Leu Asn Ile Thr Ile Lys Pro Gly Glu His Val Cys 
    450                 455                 460                 


Ala Val Gly Pro Ser Gly Ser Gly Lys Ser Thr Ile Ala Ser Leu Leu 
465                 470                 475                 480 


Leu Arg Tyr Tyr Asp Val Asn Ser Gly Ser Ile Glu Phe Gly Asp Glu 
                485                 490                 495     


Asp Ile Arg Asn Phe Asn Leu Arg Lys Tyr Arg Arg Leu Ile Gly Tyr 
            500                 505                 510         


Val Gln Gln Glu Pro Leu Leu Phe Asn Gly Thr Ile Leu Asp Asn Ile 
        515                 520                 525             


Leu Tyr Cys Ile Pro Pro Glu Ile Ala Glu Gln Asp Asp Arg Ile Arg 
    530                 535                 540                 


Arg Ala Ile Gly Lys Ala Asn Cys Thr Lys Phe Leu Ala Asn Phe Pro 
545                 550                 555                 560 


Asp Gly Leu Gln Thr Met Val Gly Ala Arg Gly Ala Gln Leu Ser Gly 
                565                 570                 575     


Gly Gln Lys Gln Arg Ile Ala Leu Ala Arg Ala Phe Leu Leu Asp Pro 
            580                 585                 590         


Ala Val Leu Ile Leu Asp Glu Ala Thr Ser Ala Leu Asp Ser Gln Ser 
        595                 600                 605             


Glu Glu Ile Val Ala Lys Asn Leu Gln Arg Arg Val Glu Arg Gly Phe 
    610                 615                 620                 


Thr Thr Ile Ser Ile Ala His Arg Leu Ser Thr Ile Lys His Ser Thr 
625                 630                 635                 640 


Arg Val Ile Val Leu Gly Lys His Gly Ser Val Val Glu Thr Gly Ser 
                645                 650                 655     


Phe Arg Asp Leu Ile Ala Ile Pro Asn Ser Glu Leu Asn Ala Leu Leu 
            660                 665                 670         


Ala Glu Gln Gln Asp Glu Glu Gly Lys Gly Gly Val Ile Asp Leu Asp 
        675                 680                 685             


Asn Ser Val Ala Arg Glu Val 
    690                 695 


<210>  11
<211>  773
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Leu Asn Gly Arg Leu Pro Leu Leu Arg Leu Gly Ile Cys Arg Asn 
1               5                   10                  15      


Met Leu Ser Arg Pro Arg Leu Ala Lys Leu Pro Ser Ile Arg Phe Arg 
            20                  25                  30          


Ser Leu Val Thr Pro Ser Ser Ser Gln Leu Ile Pro Leu Ser Arg Leu 
        35                  40                  45              


Cys Leu Arg Ser Pro Ala Val Gly Lys Ser Leu Ile Leu Gln Ser Phe 
    50                  55                  60                  


Arg Cys Asn Ser Ser Lys Thr Val Pro Glu Thr Ser Leu Pro Ser Ala 
65                  70                  75                  80  


Ser Pro Ile Ser Lys Gly Ser Ala Arg Ser Ala His Ala Lys Glu Gln 
                85                  90                  95      


Ser Lys Thr Asp Asp Tyr Lys Asp Ile Ile Arg Leu Phe Met Leu Ala 
            100                 105                 110         


Lys Arg Asp Trp Lys Leu Leu Leu Thr Ala Ile Leu Leu Leu Thr Ile 
        115                 120                 125             


Ser Cys Ser Ile Gly Met Ser Ile Pro Lys Val Ile Gly Ile Val Leu 
    130                 135                 140                 


Asp Thr Leu Lys Thr Ser Ser Gly Ser Asp Phe Phe Asp Leu Lys Ile 
145                 150                 155                 160 


Pro Ile Phe Ser Leu Pro Leu Tyr Glu Phe Leu Ser Phe Phe Thr Val 
                165                 170                 175     


Ala Leu Leu Ile Gly Cys Ala Ala Asn Phe Gly Arg Phe Ile Leu Leu 
            180                 185                 190         


Arg Ile Leu Ser Glu Arg Val Val Ala Arg Leu Arg Ala Asn Val Ile 
        195                 200                 205             


Lys Lys Thr Leu His Gln Asp Ala Glu Phe Phe Asp Asn His Lys Val 
    210                 215                 220                 


Gly Asp Leu Ile Ser Arg Leu Gly Ser Asp Ala Tyr Val Val Ser Arg 
225                 230                 235                 240 


Ser Met Thr Gln Lys Val Ser Asp Gly Val Lys Ala Leu Ile Cys Gly 
                245                 250                 255     


Val Val Gly Val Gly Met Met Cys Ser Leu Ser Pro Gln Leu Ser Ile 
            260                 265                 270         


Leu Leu Leu Phe Phe Thr Pro Pro Val Leu Phe Ser Ala Ser Val Phe 
        275                 280                 285             


Gly Lys Gln Ile Arg Asn Thr Ser Lys Asp Leu Gln Glu Ala Thr Gly 
    290                 295                 300                 


Gln Leu Thr Arg Val Ala Glu Glu Gln Leu Ser Gly Ile Lys Thr Val 
305                 310                 315                 320 


Gln Ser Phe Val Ala Glu Gly Asn Glu Leu Ser Arg Tyr Asn Val Ala 
                325                 330                 335     


Ile Arg Asp Ile Phe Gln Val Gly Lys Thr Ala Ala Phe Thr Asn Ala 
            340                 345                 350         


Lys Phe Phe Thr Thr Thr Ser Leu Leu Gly Asp Leu Ser Phe Leu Thr 
        355                 360                 365             


Val Leu Ala Tyr Gly Ser Tyr Leu Val Leu Gln Ser Gln Leu Ser Ile 
    370                 375                 380                 


Gly Asp Leu Thr Ala Phe Met Leu Tyr Thr Glu Tyr Thr Gly Asn Ala 
385                 390                 395                 400 


Val Phe Gly Leu Ser Thr Phe Tyr Ser Glu Ile Met Gln Gly Ala Gly 
                405                 410                 415     


Ala Ala Ser Arg Leu Phe Glu Leu Thr Asp Arg Lys Pro Ser Ile Ser 
            420                 425                 430         


Pro Thr Val Gly His Lys Tyr Lys Pro Asp Arg Gly Val Ile Glu Phe 
        435                 440                 445             


Lys Asp Val Ser Phe Ser Tyr Pro Thr Arg Pro Ser Val Gln Ile Phe 
    450                 455                 460                 


Lys Asn Leu Asn Phe Lys Ile Ala Pro Gly Ser Ser Val Cys Ile Val 
465                 470                 475                 480 


Gly Pro Ser Gly Arg Gly Lys Ser Thr Ile Ala Leu Leu Leu Leu Arg 
                485                 490                 495     


Tyr Tyr Asn Pro Thr Thr Gly Thr Ile Thr Ile Asp Asn Gln Asp Ile 
            500                 505                 510         


Ser Lys Leu Asn Cys Lys Ser Leu Arg Arg His Ile Gly Ile Val Gln 
        515                 520                 525             


Gln Glu Pro Val Leu Met Ser Gly Thr Ile Arg Asp Asn Ile Thr Tyr 
    530                 535                 540                 


Gly Leu Thr Tyr Thr Pro Thr Lys Glu Glu Ile Arg Ser Val Ala Lys 
545                 550                 555                 560 


Gln Cys Phe Cys His Asn Phe Ile Thr Lys Phe Pro Asn Thr Tyr Asp 
                565                 570                 575     


Thr Val Ile Gly Pro His Gly Thr Leu Leu Ser Gly Gly Gln Lys Gln 
            580                 585                 590         


Arg Ile Ala Ile Ala Arg Ala Leu Ile Lys Lys Pro Thr Ile Leu Ile 
        595                 600                 605             


Leu Asp Glu Ala Thr Ser Ala Leu Asp Val Glu Ser Glu Gly Ala Ile 
    610                 615                 620                 


Asn Tyr Thr Phe Gly Gln Leu Met Lys Ser Lys Ser Met Thr Ile Val 
625                 630                 635                 640 


Ser Ile Ala His Arg Leu Ser Thr Ile Arg Arg Ser Glu Asn Val Ile 
                645                 650                 655     


Val Leu Gly His Asp Gly Ser Val Val Glu Met Gly Lys Phe Lys Glu 
            660                 665                 670         


Leu Tyr Ala Asn Pro Thr Ser Ala Leu Ser Gln Leu Leu Asn Glu Lys 
        675                 680                 685             


Ala Ala Pro Gly Pro Ser Asp Gln Gln Leu Gln Ile Glu Lys Val Ile 
    690                 695                 700                 


Glu Lys Glu Asp Leu Asn Glu Ser Lys Glu His Asp Asp Gln Lys Lys 
705                 710                 715                 720 


Asp Asp Asn Asp Asp Asn Asp Asn Asn His Asp Asn Asp Ser Asn Asn 
                725                 730                 735     


Gln Ser Pro Glu Thr Lys Asp Asn Asn Ser Asp Asp Ile Glu Lys Ser 
            740                 745                 750         


Val Glu His Leu Leu Lys Asp Ala Ala Lys Glu Ala Asn Pro Ile Lys 
        755                 760                 765             


Ile Thr Pro Gln Pro 
    770             


<210>  12
<211>  1218
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Ile Lys Asn Gly Thr Cys Pro Tyr Trp Glu Arg Asp Asp Leu Ser 
1               5                   10                  15      


Glu Cys Ala Arg Arg Glu Tyr Ile Glu Phe Lys Phe Pro Leu Phe Ile 
            20                  25                  30          


Leu Leu Thr Gly Met Ile Tyr Ala Phe Cys Lys Val Phe Arg Ala Phe 
        35                  40                  45              


Tyr Leu Arg Gly Lys Asn His Thr Asn Glu Ala Pro Glu Phe Glu Glu 
    50                  55                  60                  


Gln Gly Asn Gly Asn His Glu Tyr Ala Arg Phe Ser Val Leu Arg Leu 
65                  70                  75                  80  


Lys Ser Ala Trp Glu Ser Arg Ser Phe Cys Asn Val Asn Asn Arg Ser 
                85                  90                  95      


Thr Phe Asp Lys Phe Lys Lys Phe Ile Glu Gly Ala Phe Ile Val Leu 
            100                 105                 110         


Gln Leu Thr Ile His Leu Tyr Ile Leu Ser Ser Met Pro Met Asp Asn 
        115                 120                 125             


Lys Lys Phe Phe His Gln Gly Phe Leu Val Gln Met Phe Leu Trp Ile 
    130                 135                 140                 


Leu Leu Leu Val Val Ile Thr Leu Arg Leu Ile Ser Ala Ser Gln Ser 
145                 150                 155                 160 


Phe Arg Trp Val Leu Ala Cys Lys Arg Asp Leu Trp Ala Val Ser Phe 
                165                 170                 175     


Tyr Ser Tyr Ala Ser Leu Phe Thr Leu Ser Ile Leu Pro Leu Arg Ser 
            180                 185                 190         


Val Phe Ile Gly Lys Ile Lys Asp Lys Ile Met Val Lys Tyr Ile Ile 
        195                 200                 205             


Ser Glu Thr Phe Ile Asp Leu Ala Leu Leu Leu Leu Leu Ser Thr Ser 
    210                 215                 220                 


Ser Ile Glu Gly Thr Arg Tyr Ser Phe Leu Val Glu Asn Glu Asn Lys 
225                 230                 235                 240 


Lys Leu Pro Pro Ala Pro Thr Val Phe Gly Leu Leu Thr Phe Ser Arg 
                245                 250                 255     


Ile Asp Arg Leu Ile Trp Lys Ala Tyr Lys His Cys Leu Gly Asn Ala 
            260                 265                 270         


Asp Ile Trp Asp Leu Asp Ile Asn Asn Lys Ser Ile Ala Ile Leu Ala 
        275                 280                 285             


Asn Phe Glu Met Ser Ser Lys Lys Gly Arg Leu Leu Pro Asn Ile Ile 
    290                 295                 300                 


Cys Tyr Phe Lys Ala Val Phe Ile Ser Gln Leu Phe Leu Ala Phe Val 
305                 310                 315                 320 


Ser Ser Phe Leu Asn Phe Val Pro Ser Leu Leu Met Pro Arg Ile Leu 
                325                 330                 335     


Ser Tyr Val Asn Asp Pro Lys Ser Lys Ser Trp Asn Leu Val Ser Leu 
            340                 345                 350         


Tyr Val Ser Ser Met Leu Val Ser Lys Ile Ile Ala Thr Thr Cys Arg 
        355                 360                 365             


Gly Gln Gly Leu Phe Leu Gly Glu Lys Gly Thr Met Gln Leu Arg Thr 
    370                 375                 380                 


Val Leu Ile Ser Asn Ile Tyr Ser Lys Thr Leu Arg Arg Thr Ile Leu 
385                 390                 395                 400 


Lys Asp Ser Thr Thr Ser Leu Gln Lys Asn Ala Ser Thr Ser Phe Glu 
                405                 410                 415     


Glu Asn Pro Asp Ser Ser Glu Ala Glu Pro Arg Lys Lys Ser Ser Arg 
            420                 425                 430         


Lys Asp Asn Ser Val Asn Asn Val Met Ser Ile Asp Ala Phe Lys Val 
        435                 440                 445             


Ser Glu Ala Met Asn Thr Phe Tyr Leu Ala Cys Glu Ala Val Phe Met 
    450                 455                 460                 


Thr Val Thr Ala Leu Met Ile Leu Tyr Ser Leu Leu Gly Trp Ser Ala 
465                 470                 475                 480 


Phe Ala Gly Thr Phe Ala Leu Leu Ala Met Ile Pro Leu Asn Phe Trp 
                485                 490                 495     


Cys Ala Thr Phe Tyr Gly Asn Tyr Gln Ala Asp Gln Leu Ile Leu Thr 
            500                 505                 510         


Asp Lys Arg Thr Ser Gly Ile Ser Glu Ala Leu Asn Ser Ile Arg Val 
        515                 520                 525             


Ile Lys Leu Leu Ala Trp Glu Asn Leu Phe Tyr Gln Lys Ile Ile Asn 
    530                 535                 540                 


Val Arg Asp Gly Glu Ile Arg Leu Leu Lys Lys Lys Ala Thr Ile Phe 
545                 550                 555                 560 


Phe Leu Asn His Leu Ile Trp Phe Phe Gly Pro Thr Leu Val Ser Ala 
                565                 570                 575     


Ile Thr Phe Ser Val Phe Ile Lys Phe Gln Asn Gln Thr Leu Thr Pro 
            580                 585                 590         


Thr Ile Ala Phe Thr Ala Leu Ser Leu Phe Ala Ile Leu Arg Thr Pro 
        595                 600                 605             


Met Asp Gln Ile Ala Ser Thr Val Ser Leu Leu Ile Gln Ser Phe Ile 
    610                 615                 620                 


Ser Leu Glu Arg Ile Gln Asp Tyr Leu Asn Glu Ser Glu Thr Arg Lys 
625                 630                 635                 640 


Tyr Glu Ile Leu Glu Gln Ser Asn Thr Lys Phe Gly Phe Glu Asp Ala 
                645                 650                 655     


Ser Met Glu Trp Glu Ala Ala Glu Thr Ser Phe Lys Leu Lys Asn Ile 
            660                 665                 670         


Ser Ile Asp Phe Lys Leu Asn Ser Leu Asn Ala Ile Ile Gly Pro Thr 
        675                 680                 685             


Gly Ser Gly Lys Ser Ser Leu Leu Leu Gly Leu Leu Gly Glu Leu Asn 
    690                 695                 700                 


Leu Leu Ser Gly Lys Ile Tyr Val Pro Thr Val Glu Ser Arg Asp Asp 
705                 710                 715                 720 


Leu Glu Ile Gly Lys Asp Gly Met Thr Asn Ser Met Ala Tyr Cys Ser 
                725                 730                 735     


Gln Thr Pro Trp Leu Ile Ser Gly Thr Ile Lys Asp Asn Val Val Phe 
            740                 745                 750         


Gly Glu Ile Phe Asn Lys Gln Lys Phe Asp Asp Val Met Lys Ser Cys 
        755                 760                 765             


Cys Leu Asp Lys Asp Ile Lys Ala Met Thr Ala Gly Ile Arg Thr Asp 
    770                 775                 780                 


Val Gly Asp Gly Gly Phe Ser Leu Ser Gly Gly Gln Gln Gln Arg Ile 
785                 790                 795                 800 


Ala Leu Ala Arg Ala Ile Tyr Ser Ser Ser Arg Tyr Leu Ile Leu Asp 
                805                 810                 815     


Asp Cys Leu Ser Ala Val Asp Pro Glu Thr Ala Leu Tyr Ile Tyr Glu 
            820                 825                 830         


Glu Cys Leu Cys Gly Pro Met Met Lys Gly Arg Thr Cys Ile Ile Thr 
        835                 840                 845             


Ser His Asn Ile Ser Leu Val Thr Lys Arg Ala Asp Trp Leu Val Ile 
    850                 855                 860                 


Leu Asp Arg Gly Glu Val Lys Ser Gln Gly Lys Pro Ser Asp Leu Ile 
865                 870                 875                 880 


Lys Ser Asn Glu Phe Leu Arg Glu Ser Ile Asn Asn Asp Ser Lys Asn 
                885                 890                 895     


Thr Thr His Asn Gln Ile Asp Leu Lys Arg Ser Thr Thr Ser Lys Lys 
            900                 905                 910         


Thr Lys Asn Gly Asp Pro Glu Gly Gly Asn Ser Gln Asp Glu Val Cys 
        915                 920                 925             


Ala Glu Val Glu Asn Phe Glu Glu Thr Lys Met Glu Gly Ser Val Lys 
    930                 935                 940                 


Phe Ser Ala Tyr Lys Trp Leu Ala Asp Tyr Phe Gly Gly Leu Gly Val 
945                 950                 955                 960 


Val Phe Val Phe Thr Ser Ser Ser Ile Leu Ile His Gly Ile Thr Leu 
                965                 970                 975     


Ser Gln Gly Phe Trp Leu Arg Tyr Trp Leu Asp Thr Gly Ser Ser Gly 
            980                 985                 990         


Ser Lys Ser Thr Trp Leu Tyr Arg  Ile Val Glu Gly His  Ser Asn Ile 
        995                 1000                 1005             


Tyr Phe  Leu Leu Thr Tyr Ile  Ile Ile Gly Leu Val  Ser Ser Phe 
    1010                 1015                 1020             


Leu Thr  Ser Gly Lys Val Trp  Ile Ala Ile Ile Ser  Gly Thr Asn 
    1025                 1030                 1035             


Val Thr  Lys Lys Ile Phe Ala  Lys Leu Leu Ser Ser  Ile Leu Tyr 
    1040                 1045                 1050             


Ala Lys  Leu Arg Phe His Asn  Val Thr Pro Thr Gly  Arg Ile Met 
    1055                 1060                 1065             


Asn Arg  Phe Ser Lys Asp Met  Asp Ile Ile Asp Gln  Gln Leu Ile 
    1070                 1075                 1080             


Pro Asn  Phe Glu Gly Leu Ser  Tyr Ser Val Val Val  Cys Leu Trp 
    1085                 1090                 1095             


Ile Ile  Leu Leu Ile Gly Tyr  Val Thr Pro Gln Phe  Leu Leu Phe 
    1100                 1105                 1110             


Ala Ile  Pro Leu Cys Ala Leu  Tyr Tyr Thr Val Cys  Thr Leu Tyr 
    1115                 1120                 1125             


Leu Arg  Ala Ser Arg Glu Leu  Lys Arg Ile Asp Asn  Ile Asn Ile 
    1130                 1135                 1140             


Ser Pro  Ile His Gln Leu Phe  Ala Glu Ala Ile Lys  Gly Val Thr 
    1145                 1150                 1155             


Thr Ile  Arg Ala Leu Ala Asp  Glu Arg Arg Phe Ile  Thr Gln Ser 
    1160                 1165                 1170             


Leu Val  Ala Ile Asp Arg Ser  Asn Ala Pro Phe Phe  Tyr Leu Asn 
    1175                 1180                 1185             


Met Ala  Thr Glu Trp Ile Thr  Tyr Arg Val Asp Ile  Ile Gly Thr 
    1190                 1195                 1200             


Leu Val  Leu Phe Ser Ser Ser  Val Met Ile Ile Met  Lys Ala Ser 
    1205                 1210                 1215             


<210>  13
<211>  1511
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Pro Glu Ala Lys Leu Asn Asn Asn Val Asn Asp Val Thr Ser Tyr 
1               5                   10                  15      


Ser Ser Ala Ser Ser Ser Thr Glu Asn Ala Ala Asp Leu His Asn Tyr 
            20                  25                  30          


Asn Gly Phe Asp Glu His Thr Glu Ala Arg Ile Gln Lys Leu Ala Arg 
        35                  40                  45              


Thr Leu Thr Ala Gln Ser Met Gln Asn Ser Thr Gln Ser Ala Pro Asn 
    50                  55                  60                  


Lys Ser Asp Ala Gln Ser Ile Phe Ser Ser Gly Val Glu Gly Val Asn 
65                  70                  75                  80  


Pro Ile Phe Ser Asp Pro Glu Ala Pro Gly Tyr Asp Pro Lys Leu Asp 
                85                  90                  95      


Pro Asn Ser Glu Asn Phe Ser Ser Ala Ala Trp Val Lys Asn Met Ala 
            100                 105                 110         


His Leu Ser Ala Ala Asp Pro Asp Phe Tyr Lys Pro Tyr Ser Leu Gly 
        115                 120                 125             


Cys Ala Trp Lys Asn Leu Ser Ala Ser Gly Ala Ser Ala Asp Val Ala 
    130                 135                 140                 


Tyr Gln Ser Thr Val Val Asn Ile Pro Tyr Lys Ile Leu Lys Ser Gly 
145                 150                 155                 160 


Leu Arg Lys Phe Gln Arg Ser Lys Glu Thr Asn Thr Phe Gln Ile Leu 
                165                 170                 175     


Lys Pro Met Asp Gly Cys Leu Asn Pro Gly Glu Leu Leu Val Val Leu 
            180                 185                 190         


Gly Arg Pro Gly Ser Gly Cys Thr Thr Leu Leu Lys Ser Ile Ser Ser 
        195                 200                 205             


Asn Thr His Gly Phe Asp Leu Gly Ala Asp Thr Lys Ile Ser Tyr Ser 
    210                 215                 220                 


Gly Tyr Ser Gly Asp Asp Ile Lys Lys His Phe Arg Gly Glu Val Val 
225                 230                 235                 240 


Tyr Asn Ala Glu Ala Asp Val His Leu Pro His Leu Thr Val Phe Glu 
                245                 250                 255     


Thr Leu Val Thr Val Ala Arg Leu Lys Thr Pro Gln Asn Arg Ile Lys 
            260                 265                 270         


Gly Val Asp Arg Glu Ser Tyr Ala Asn His Leu Ala Glu Val Ala Met 
        275                 280                 285             


Ala Thr Tyr Gly Leu Ser His Thr Arg Asn Thr Lys Val Gly Asn Asp 
    290                 295                 300                 


Ile Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val Ser Ile Ala 
305                 310                 315                 320 


Glu Val Ser Ile Cys Gly Ser Lys Phe Gln Cys Trp Asp Asn Ala Thr 
                325                 330                 335     


Arg Gly Leu Asp Ser Ala Thr Ala Leu Glu Phe Ile Arg Ala Leu Lys 
            340                 345                 350         


Thr Gln Ala Asp Ile Ser Asn Thr Ser Ala Thr Val Ala Ile Tyr Gln 
        355                 360                 365             


Cys Ser Gln Asp Ala Tyr Asp Leu Phe Asn Lys Val Cys Val Leu Asp 
    370                 375                 380                 


Asp Gly Tyr Gln Ile Tyr Tyr Gly Pro Ala Asp Lys Ala Lys Lys Tyr 
385                 390                 395                 400 


Phe Glu Asp Met Gly Tyr Val Cys Pro Ser Arg Gln Thr Thr Ala Asp 
                405                 410                 415     


Phe Leu Thr Ser Val Thr Ser Pro Ser Glu Arg Thr Leu Asn Lys Asp 
            420                 425                 430         


Met Leu Lys Lys Gly Ile His Ile Pro Gln Thr Pro Lys Glu Met Asn 
        435                 440                 445             


Asp Tyr Trp Val Lys Ser Pro Asn Tyr Lys Glu Leu Met Lys Glu Val 
    450                 455                 460                 


Asp Gln Arg Leu Leu Asn Asp Asp Glu Ala Ser Arg Glu Ala Ile Lys 
465                 470                 475                 480 


Glu Ala His Ile Ala Lys Gln Ser Lys Arg Ala Arg Pro Ser Ser Pro 
                485                 490                 495     


Tyr Thr Val Ser Tyr Met Met Gln Val Lys Tyr Leu Leu Ile Arg Asn 
            500                 505                 510         


Met Trp Arg Leu Arg Asn Asn Ile Gly Phe Thr Leu Phe Met Ile Leu 
        515                 520                 525             


Gly Asn Cys Ser Met Ala Leu Ile Leu Gly Ser Met Phe Phe Lys Ile 
    530                 535                 540                 


Met Lys Lys Gly Asp Thr Ser Thr Phe Tyr Phe Arg Gly Ser Ala Met 
545                 550                 555                 560 


Phe Phe Ala Ile Leu Phe Asn Ala Phe Ser Ser Leu Leu Glu Ile Phe 
                565                 570                 575     


Ser Leu Tyr Glu Ala Arg Pro Ile Thr Glu Lys His Arg Thr Tyr Ser 
            580                 585                 590         


Leu Tyr His Pro Ser Ala Asp Ala Phe Ala Ser Val Leu Ser Glu Ile 
        595                 600                 605             


Pro Ser Lys Leu Ile Ile Ala Val Cys Phe Asn Ile Ile Phe Tyr Phe 
    610                 615                 620                 


Leu Val Asp Phe Arg Arg Asn Gly Gly Val Phe Phe Phe Tyr Leu Leu 
625                 630                 635                 640 


Ile Asn Ile Val Ala Val Phe Ser Met Ser His Leu Phe Arg Cys Val 
                645                 650                 655     


Gly Ser Leu Thr Lys Thr Leu Ser Glu Ala Met Val Pro Ala Ser Met 
            660                 665                 670         


Leu Leu Leu Ala Leu Ser Met Tyr Thr Gly Phe Ala Ile Pro Lys Lys 
        675                 680                 685             


Lys Ile Leu Arg Trp Ser Lys Trp Ile Trp Tyr Ile Asn Pro Leu Ala 
    690                 695                 700                 


Tyr Leu Phe Glu Ser Leu Leu Ile Asn Glu Phe His Gly Ile Lys Phe 
705                 710                 715                 720 


Pro Cys Ala Glu Tyr Val Pro Arg Gly Pro Ala Tyr Ala Asn Ile Ser 
                725                 730                 735     


Ser Thr Glu Ser Val Cys Thr Val Val Gly Ala Val Pro Gly Gln Asp 
            740                 745                 750         


Tyr Val Leu Gly Asp Asp Phe Ile Arg Gly Thr Tyr Gln Tyr Tyr His 
        755                 760                 765             


Lys Asp Lys Trp Arg Gly Phe Gly Ile Gly Met Ala Tyr Val Val Phe 
    770                 775                 780                 


Phe Phe Phe Val Tyr Leu Phe Leu Cys Glu Tyr Asn Glu Gly Ala Lys 
785                 790                 795                 800 


Gln Lys Gly Glu Ile Leu Val Phe Pro Arg Ser Ile Val Lys Arg Met 
                805                 810                 815     


Lys Lys Arg Gly Val Leu Thr Glu Lys Asn Ala Asn Asp Pro Glu Asn 
            820                 825                 830         


Val Gly Glu Arg Ser Asp Leu Ser Ser Asp Arg Lys Met Leu Gln Glu 
        835                 840                 845             


Ser Ser Glu Glu Glu Ser Asp Thr Tyr Gly Glu Ile Gly Leu Ser Lys 
    850                 855                 860                 


Ser Glu Ala Ile Phe His Trp Arg Asn Leu Cys Tyr Glu Val Gln Ile 
865                 870                 875                 880 


Lys Ala Glu Thr Arg Arg Ile Leu Asn Asn Val Asp Gly Trp Val Lys 
                885                 890                 895     


Pro Gly Thr Leu Thr Ala Leu Met Gly Ala Ser Gly Ala Gly Lys Thr 
            900                 905                 910         


Thr Leu Leu Asp Cys Leu Ala Glu Arg Val Thr Met Gly Val Ile Thr 
        915                 920                 925             


Gly Asp Ile Leu Val Asn Gly Ile Pro Arg Asp Lys Ser Phe Pro Arg 
    930                 935                 940                 


Ser Ile Gly Tyr Cys Gln Gln Gln Asp Leu His Leu Lys Thr Ala Thr 
945                 950                 955                 960 


Val Arg Glu Ser Leu Arg Phe Ser Ala Tyr Leu Arg Gln Pro Ala Glu 
                965                 970                 975     


Val Ser Ile Glu Glu Lys Asn Arg Tyr Val Glu Glu Val Ile Lys Ile 
            980                 985                 990         


Leu Glu Met Glu Lys Tyr Ala Asp  Ala Val Val Gly Val  Ala Gly Glu 
        995                 1000                 1005             


Gly Leu  Asn Val Glu Gln Arg  Lys Arg Leu Thr Ile  Gly Val Glu 
    1010                 1015                 1020             


Leu Thr  Ala Lys Pro Lys Leu  Leu Val Phe Leu Asp  Glu Pro Thr 
    1025                 1030                 1035             


Ser Gly  Leu Asp Ser Gln Thr  Ala Trp Ser Ile Cys  Gln Leu Met 
    1040                 1045                 1050             


Lys Lys  Leu Ala Asn His Gly  Gln Ala Ile Leu Cys  Thr Ile His 
    1055                 1060                 1065             


Gln Pro  Ser Ala Ile Leu Met  Gln Glu Phe Asp Arg  Leu Leu Phe 
    1070                 1075                 1080             


Met Gln  Arg Gly Gly Lys Thr  Val Tyr Phe Gly Asp  Leu Gly Glu 
    1085                 1090                 1095             


Gly Cys  Lys Thr Met Ile Asp  Tyr Phe Glu Ser His  Gly Ala His 
    1100                 1105                 1110             


Lys Cys  Pro Ala Asp Ala Asn  Pro Ala Glu Trp Met  Leu Glu Val 
    1115                 1120                 1125             


Val Gly  Ala Ala Pro Gly Ser  His Ala Asn Gln Asp  Tyr Tyr Glu 
    1130                 1135                 1140             


Val Trp  Arg Asn Ser Glu Glu  Tyr Arg Ala Val Gln  Ser Glu Leu 
    1145                 1150                 1155             


Asp Trp  Met Glu Arg Glu Leu  Pro Lys Lys Gly Ser  Ile Thr Ala 
    1160                 1165                 1170             


Ala Glu  Asp Lys His Glu Phe  Ser Gln Ser Ile Ile  Tyr Gln Thr 
    1175                 1180                 1185             


Lys Leu  Val Ser Ile Arg Leu  Phe Gln Gln Tyr Trp  Arg Ser Pro 
    1190                 1195                 1200             


Asp Tyr  Leu Trp Ser Lys Phe  Ile Leu Thr Ile Phe  Asn Gln Leu 
    1205                 1210                 1215             


Phe Ile  Gly Phe Thr Phe Phe  Lys Ala Gly Thr Ser  Leu Gln Gly 
    1220                 1225                 1230             


Leu Gln  Asn Gln Met Leu Ala  Val Phe Met Phe Thr  Val Ile Phe 
    1235                 1240                 1245             


Asn Pro  Ile Leu Gln Gln Tyr  Leu Pro Ser Phe Val  Gln Gln Arg 
    1250                 1255                 1260             


Asp Leu  Tyr Glu Ala Arg Glu  Arg Pro Ser Arg Thr  Phe Ser Trp 
    1265                 1270                 1275             


Ile Ser  Phe Ile Phe Ala Gln  Ile Phe Val Glu Val  Pro Trp Asn 
    1280                 1285                 1290             


Ile Leu  Ala Gly Thr Ile Ala  Tyr Phe Ile Tyr Tyr  Tyr Pro Ile 
    1295                 1300                 1305             


Gly Phe  Tyr Ser Asn Ala Ser  Ala Ala Gly Gln Leu  His Glu Arg 
    1310                 1315                 1320             


Gly Ala  Leu Phe Trp Leu Phe  Ser Cys Ala Phe Tyr  Val Tyr Val 
    1325                 1330                 1335             


Gly Ser  Met Gly Leu Leu Val  Ile Ser Phe Asn Gln  Val Ala Glu 
    1340                 1345                 1350             


Ser Ala  Ala Asn Leu Ala Ser  Leu Leu Phe Thr Met  Ser Leu Ser 
    1355                 1360                 1365             


Phe Cys  Gly Val Met Thr Thr  Pro Ser Ala Met Pro  Arg Phe Trp 
    1370                 1375                 1380             


Ile Phe  Met Tyr Arg Val Ser  Pro Leu Thr Tyr Phe  Ile Gln Ala 
    1385                 1390                 1395             


Leu Leu  Ala Val Gly Val Ala  Asn Val Asp Val Lys  Cys Ala Asp 
    1400                 1405                 1410             


Tyr Glu  Leu Leu Glu Phe Thr  Pro Pro Ser Gly Met  Thr Cys Gly 
    1415                 1420                 1425             


Gln Tyr  Met Glu Pro Tyr Leu  Gln Leu Ala Lys Thr  Gly Tyr Leu 
    1430                 1435                 1440             


Thr Asp  Glu Asn Ala Thr Asp  Thr Cys Ser Phe Cys  Gln Ile Ser 
    1445                 1450                 1455             


Thr Thr  Asn Asp Tyr Leu Ala  Asn Val Asn Ser Phe  Tyr Ser Glu 
    1460                 1465                 1470             


Arg Trp  Arg Asn Tyr Gly Ile  Phe Ile Cys Tyr Ile  Ala Phe Asn 
    1475                 1480                 1485             


Tyr Ile  Ala Gly Val Phe Phe  Tyr Trp Leu Ala Arg  Val Pro Lys 
    1490                 1495                 1500             


Lys Asn  Gly Lys Leu Ser Lys  Lys 
    1505                 1510     


<210>  14
<211>  1564
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Leu Gln Ala Pro Ser Ser Ser Asn Ser Gly Leu Asn Gln Gly Asn 
1               5                   10                  15      


Ala Ala Pro Asp Gly Pro Pro Asn Glu Thr Gln Pro Tyr Glu Gly Leu 
            20                  25                  30          


Asp Ala Ala Ala Gln Glu Glu Ile Lys Glu Leu Ala Arg Thr Leu Thr 
        35                  40                  45              


Ser Gln Ser Ser Leu Leu Ser Gln Glu Lys Arg Ile Thr Gly Thr Gly 
    50                  55                  60                  


Asp Pro Asn Thr Leu Thr Ala Ala Ser Ser Ser Ser Leu Ser Arg Ser 
65                  70                  75                  80  


Ile Phe Ala Ser Asp Ile Lys Gly Val Asn Pro Ile Leu Leu Asp Val 
                85                  90                  95      


Asn Asp Pro Asp Tyr Asp Glu Thr Leu Asp Pro Arg Ser Glu Asn Phe 
            100                 105                 110         


Ser Ser Val Arg Trp Val Arg Asn Met Ala Gln Ile Cys Glu Asn Asp 
        115                 120                 125             


Ser Asp Phe Tyr Lys Pro Phe Ser Leu Gly Cys Ala Trp Lys Asp Leu 
    130                 135                 140                 


Ser Ala Ser Gly Asp Ser Ala Asp Ile Thr Tyr Gln Gly Thr Phe Gly 
145                 150                 155                 160 


Asn Met Pro Ile Lys Tyr Leu Lys Met Ser Trp Arg Cys Ile Ser Arg 
                165                 170                 175     


Arg Leu Phe His Arg Thr His Gly Lys Ser Glu Asp Asn Asp Ser Gly 
            180                 185                 190         


Phe Gln Ile Leu Lys Pro Met Asp Gly Cys Ile Asn Pro Gly Glu Leu 
        195                 200                 205             


Leu Val Val Leu Gly Arg Pro Gly Ala Gly Cys Thr Thr Leu Leu Lys 
    210                 215                 220                 


Ser Ile Ser Val Asn Thr His Gly Phe Lys Ile Ser Pro Asp Thr Ile 
225                 230                 235                 240 


Ile Thr Tyr Asn Gly Phe Ser Asn Lys Glu Ile Lys Asn His Tyr Arg 
                245                 250                 255     


Gly Glu Val Val Tyr Asn Ala Glu Ser Asp Ile His Ile Pro His Leu 
            260                 265                 270         


Thr Val Phe Gln Thr Leu Tyr Thr Val Ala Arg Leu Lys Thr Pro Arg 
        275                 280                 285             


Asn Arg Ile Lys Gly Val Asp Arg Asp Thr Phe Ala Lys His Met Thr 
    290                 295                 300                 


Glu Val Ala Met Ala Thr Tyr Gly Leu Ser His Thr Ala Asp Thr Lys 
305                 310                 315                 320 


Val Gly Asn Asp Phe Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg 
                325                 330                 335     


Val Ser Ile Ala Glu Val Ser Ile Cys Gly Ser Lys Phe Gln Cys Trp 
            340                 345                 350         


Asp Asn Ala Thr Arg Gly Leu Asp Ser Ala Thr Ala Leu Glu Phe Ile 
        355                 360                 365             


Lys Ala Leu Lys Thr Gln Ala Thr Ile Thr Lys Ser Ala Ala Thr Val 
    370                 375                 380                 


Ala Ile Tyr Gln Cys Ser Lys Asp Ala Tyr Asp Leu Phe Asp Lys Val 
385                 390                 395                 400 


Cys Val Leu Tyr Asp Gly Tyr Gln Ile Phe Phe Gly Pro Ser Lys Gln 
                405                 410                 415     


Ala Lys Lys Tyr Phe Gln Arg Met Gly Tyr Val Cys Pro Glu Arg Gln 
            420                 425                 430         


Thr Thr Ala Asp Tyr Leu Thr Ser Ile Thr Ser Pro Ser Glu Arg Ile 
        435                 440                 445             


Lys Asp Lys Asp Met Val Lys His Gly Ile Met Ile Pro Gln Thr Ala 
    450                 455                 460                 


Tyr Glu Met Asn Gln Tyr Trp Ile Gln Ser Glu Glu Tyr Lys Gln Leu 
465                 470                 475                 480 


Gln Val Gln Val Asn Lys His Leu Asp Thr Asp Ser Ser Gln Gln Arg 
                485                 490                 495     


Glu Gln Ile Lys Asn Ala His Ile Ala Lys Gln Ser Lys Arg Ala Arg 
            500                 505                 510         


Pro Ser Ser Pro Tyr Thr Val Ser Phe Phe Leu Gln Val Lys Tyr Ile 
        515                 520                 525             


Leu Ile Arg Asp Ile Trp Arg Ile Lys Asn Asp Pro Ser Ile Gln Leu 
    530                 535                 540                 


Phe Thr Val Leu Ser His Ala Ala Met Ala Leu Ile Leu Gly Ser Met 
545                 550                 555                 560 


Phe Tyr Glu Val Met Leu Ser Thr Thr Thr Thr Thr Phe Tyr Tyr Arg 
                565                 570                 575     


Gly Ala Ala Ile Phe Phe Ala Ile Leu Phe Asn Ala Phe Ser Ser Leu 
            580                 585                 590         


Leu Glu Ile Phe Ser Leu Tyr Glu Thr Arg Pro Ile Thr Glu Lys His 
        595                 600                 605             


Lys Thr Tyr Ser Leu Tyr Arg Pro Ser Ala Asp Ala Phe Ala Ser Thr 
    610                 615                 620                 


Phe Ser Asp Val Pro Thr Lys Leu Ala Thr Ala Val Thr Phe Asn Ile 
625                 630                 635                 640 


Pro Tyr Tyr Phe Leu Ile Asn Leu Lys Arg Asp Ala Gly Ala Phe Phe 
                645                 650                 655     


Phe Tyr Phe Leu Ile Asn Ile Ile Thr Val Phe Ala Met Ser His Leu 
            660                 665                 670         


Phe Arg Cys Ile Gly Ser Val Ser Lys Thr Leu Pro Gln Ala Met Val 
        675                 680                 685             


Pro Ala Ser Val Leu Leu Leu Ala Phe Ala Met Tyr Thr Gly Phe Ala 
    690                 695                 700                 


Ile Pro Arg Val Gln Met Leu Gly Trp Ser Lys Trp Ile Ser Tyr Ile 
705                 710                 715                 720 


Asn Pro Leu Ser Tyr Leu Phe Glu Ser Leu Met Ile Asn Glu Phe His 
                725                 730                 735     


Gly Arg Asn Phe Pro Cys Ala Gln Tyr Ile Pro Ser Gly Pro Asn Tyr 
            740                 745                 750         


Val Asn Ala Thr Gly Asp Glu Val Thr Cys Ser Ala Leu Gly Ser Ile 
        755                 760                 765             


Pro Gly Asn Asn Tyr Val Ser Gly Asp Asp Phe Ile Gln Thr Asn Tyr 
    770                 775                 780                 


Gly Tyr Arg His Lys Asn Lys Trp Arg Ser Val Gly Ile Gly Leu Ala 
785                 790                 795                 800 


Tyr Ile Ile Phe Phe Leu Phe Leu Tyr Leu Phe Phe Cys Glu Tyr Asn 
                805                 810                 815     


Glu Gly Ala Lys Gln Asn Gly Glu Met Leu Val Phe Pro His Ser Val 
            820                 825                 830         


Val Lys Lys Met Lys Lys Lys Gly Ile Val Ser Glu Lys Lys Lys Lys 
        835                 840                 845             


Asn Gln Pro Thr Leu Ser Thr Ser Asp Ala Glu Lys Asp Val Glu Met 
    850                 855                 860                 


Asn Asn Asn Ser Ser Ala Thr Asp Ser Arg Phe Leu Arg Asp Ser Asp 
865                 870                 875                 880 


Ala Ala Ile Met Gly Asn Asp Lys Thr Val Ala Lys Glu His Tyr Ser 
                885                 890                 895     


Ser Pro Ser Ser Ser Ala Ser Gln Ser Asn Ser Phe Ser Lys Ser Asp 
            900                 905                 910         


Asp Ile Glu Leu Ser Lys Ser Gln Ala Ile Phe His Trp Lys Asn Leu 
        915                 920                 925             


Cys Tyr Asp Ile Pro Ile Lys Asn Gly Lys Arg Arg Ile Leu Asp Asn 
    930                 935                 940                 


Val Asp Gly Trp Val Lys Pro Gly Thr Leu Thr Ala Leu Ile Gly Ala 
945                 950                 955                 960 


Ser Gly Ala Gly Lys Thr Thr Leu Leu Asp Cys Leu Ala Glu Arg Thr 
                965                 970                 975     


Thr Met Gly Leu Ile Thr Gly Asp Val Phe Val Asp Gly Arg Pro Arg 
            980                 985                 990         


Asp Gln Ser Phe Pro Arg Ser Ile  Gly Tyr Cys Gln Gln  Gln Asp Leu 
        995                 1000                 1005             


His Leu  Lys Thr Ala Thr Val  Arg Glu Ser Leu Arg  Phe Ser Ala 
    1010                 1015                 1020             


Tyr Leu  Arg Gln Ala Asp Asp  Val Ser Ile Glu Glu  Lys Asp Lys 
    1025                 1030                 1035             


Tyr Val  Glu Glu Val Ile Glu  Val Leu Glu Met Lys  Leu Tyr Ala 
    1040                 1045                 1050             


Asp Ala  Ile Val Gly Val Pro  Gly Glu Gly Leu Asn  Val Glu Gln 
    1055                 1060                 1065             


Arg Lys  Arg Leu Thr Ile Gly  Val Glu Leu Ala Ala  Lys Pro Lys 
    1070                 1075                 1080             


Leu Leu  Val Phe Leu Asp Glu  Pro Thr Ser Gly Leu  Asp Ser Gln 
    1085                 1090                 1095             


Thr Ala  Trp Ser Thr Cys Gln  Leu Met Lys Lys Leu  Ala Ser Arg 
    1100                 1105                 1110             


Gly Gln  Ala Ile Leu Cys Thr  Ile His Gln Pro Ser  Ala Leu Leu 
    1115                 1120                 1125             


Met Gln  Glu Phe Asp Arg Leu  Leu Phe Leu Gln Glu  Gly Gly Gln 
    1130                 1135                 1140             


Thr Val  Tyr Phe Gly Glu Leu  Gly Lys Gly Cys Lys  Thr Met Ile 
    1145                 1150                 1155             


Asn Tyr  Phe Glu Ala His Gly  Ala His Lys Cys Pro  Pro Asp Ala 
    1160                 1165                 1170             


Asn Pro  Ala Glu Trp Met Leu  Glu Ile Val Gly Ala  Ala Pro Gly 
    1175                 1180                 1185             


Thr His  Ala Ser Gln Asp Tyr  Phe Ala Ile Trp Arg  Asp Ser Glu 
    1190                 1195                 1200             


Glu Tyr  Arg Glu Met Gln Lys  Glu Leu Asp Trp Met  Glu Arg Glu 
    1205                 1210                 1215             


Leu Pro  Lys Arg Thr Glu Gly  Ser Ser Asn Glu Glu  Gln Lys Glu 
    1220                 1225                 1230             


Phe Ala  Thr Ser Thr Leu Tyr  Gln Ile Lys Leu Val  Ser Tyr Arg 
    1235                 1240                 1245             


Leu Phe  His Gln Tyr Trp Arg  Thr Pro Phe Tyr Leu  Trp Ser Lys 
    1250                 1255                 1260             


Phe Phe  Ser Thr Ile Val Ser  Glu Leu Phe Ile Gly  Phe Thr Phe 
    1265                 1270                 1275             


Phe Lys  Ala Asn Thr Ser Leu  Gln Gly Leu Gln Asn  Gln Met Leu 
    1280                 1285                 1290             


Ala Ile  Phe Met Phe Thr Val  Val Phe Asn Pro Ile  Leu Gln Gln 
    1295                 1300                 1305             


Tyr Leu  Pro Leu Phe Val Gln  Gln Arg Glu Leu Tyr  Glu Ala Arg 
    1310                 1315                 1320             


Glu Arg  Pro Ser Arg Thr Phe  Ser Trp Lys Ala Phe  Ile Val Ser 
    1325                 1330                 1335             


Gln Ile  Leu Val Glu Ile Pro  Trp Asn Leu Leu Ala  Gly Thr Ile 
    1340                 1345                 1350             


Ala Phe  Phe Val Tyr Tyr Tyr  Pro Val Gly Phe Tyr  Arg Asn Ala 
    1355                 1360                 1365             


Ser Tyr  Ala Asn Gln Leu His  Glu Arg Gly Ala Leu  Phe Trp Leu 
    1370                 1375                 1380             


Phe Ala  Cys Ala Phe Tyr Val  Tyr Ile Ser Ser Met  Gly Val Leu 
    1385                 1390                 1395             


Val Ile  Ser Cys Ile Glu Ile  Ala Glu Asn Ala Ala  Asn Leu Ala 
    1400                 1405                 1410             


Ser Leu  Phe Phe Ile Met Ser  Leu Ser Phe Cys Gly  Val Leu Ala 
    1415                 1420                 1425             


Thr Pro  Asn Ile Leu Pro Arg  Phe Trp Ile Phe Met  Tyr Arg Val 
    1430                 1435                 1440             


Ser Pro  Leu Thr Tyr Leu Ile  Asp Ala Leu Leu Ser  Val Gly Leu 
    1445                 1450                 1455             


Ala Asn  Ala Ser Val Val Cys  Ser Ser Asn Glu Leu  Leu Lys Ile 
    1460                 1465                 1470             


Val Pro  Pro Ser Gly Met Thr  Cys Ser Glu Tyr Met  Glu Pro Tyr 
    1475                 1480                 1485             


Met Gln  Ser Thr Gly Thr Gly  Tyr Leu Leu Asp Gly  Ser Ser Glu 
    1490                 1495                 1500             


Thr Glu  Cys His Phe Cys Gln  Phe Ser Ser Thr Asn  Asp Tyr Leu 
    1505                 1510                 1515             


Ala Thr  Val Ser Ser Ser Tyr  Ser Arg Arg Trp Met  Asn Tyr Gly 
    1520                 1525                 1530             


Ile Phe  Ser Ala Tyr Ile Val  Phe Asp Tyr Cys Ala  Ala Ile Phe 
    1535                 1540                 1545             


Leu Tyr  Trp Leu Val Arg Val  Pro Lys Lys Ser Lys  Lys Leu Lys 
    1550                 1555                 1560             


Lys 
    


<210>  15
<211>  1411
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Ser Leu Ser Lys Tyr Phe Asn Pro Ile Pro Asp Ala Ser Val Thr 
1               5                   10                  15      


Phe Asp Gly Ala Thr Val Gln Leu Glu Glu Ser Leu Gly Ala Val Gln 
            20                  25                  30          


Asn Asp Glu Glu Ser Ala Ser Glu Phe Lys Asn Val Gly His Leu Glu 
        35                  40                  45              


Ile Ser Asp Ile Thr Phe Arg Ala Asn Glu Gly Glu Val Val Leu Val 
    50                  55                  60                  


Leu Gly Asn Pro Thr Ser Ala Leu Phe Lys Gly Leu Phe His Gly His 
65                  70                  75                  80  


Lys His Leu Lys Tyr Ser Pro Glu Gly Ser Ile Arg Phe Lys Asp Asn 
                85                  90                  95      


Glu Tyr Lys Gln Phe Ala Ser Lys Cys Pro His Gln Ile Ile Tyr Asn 
            100                 105                 110         


Asn Glu Gln Asp Ile His Phe Pro Tyr Leu Thr Val Glu Gln Thr Ile 
        115                 120                 125             


Asp Phe Ala Leu Ser Cys Lys Phe His Ile Pro Lys Gln Glu Arg Ile 
    130                 135                 140                 


Glu Met Arg Asp Glu Leu Leu Lys Glu Phe Gly Leu Ser His Val Lys 
145                 150                 155                 160 


Lys Thr Tyr Val Gly Asn Asp Tyr Val Arg Gly Val Ser Gly Gly Glu 
                165                 170                 175     


Arg Lys Arg Ile Ser Ile Ile Glu Thr Phe Ile Ala Asn Gly Ser Val 
            180                 185                 190         


Tyr Leu Trp Asp Asn Ser Thr Lys Gly Leu Asp Ser Ala Thr Ala Leu 
        195                 200                 205             


Glu Phe Leu Ser Ile Thr Gln Lys Met Ala Lys Ala Thr Arg Ser Val 
    210                 215                 220                 


Asn Phe Val Lys Ile Ser Gln Ala Ser Asp Lys Ile Val Ser Lys Phe 
225                 230                 235                 240 


Asp Lys Ile Leu Met Leu Gly Asp Ser Phe Gln Val Phe Tyr Gly Thr 
                245                 250                 255     


Met Glu Glu Cys Leu Thr His Phe His Asp Thr Leu Gln Ile Lys Lys 
            260                 265                 270         


Asn Pro Asn Asp Cys Ile Ile Glu Tyr Leu Thr Ser Ile Leu Asn Phe 
        275                 280                 285             


Lys Phe Lys Glu Thr Ser Asn Ser Ile Val Gly Leu Asp Thr Pro Ser 
    290                 295                 300                 


Val Val Ser Glu Glu Asn Gln Ala Leu Asn Ile Asn Asn Glu Thr Asp 
305                 310                 315                 320 


Leu His Thr Leu Trp Ile Gln Ser Pro Tyr Tyr Lys His Trp Lys Ala 
                325                 330                 335     


Ile Thr Ser Lys Thr Val Gln Glu Cys Thr Arg Lys Asp Val Asn Pro 
            340                 345                 350         


Asp Asp Ile Ser Pro Ile Phe Ser Ile Pro Leu Lys Thr Gln Leu Lys 
        355                 360                 365             


Thr Cys Thr Val Arg Ala Phe Glu Arg Ile Ile Gly Asp Arg Asn Tyr 
    370                 375                 380                 


Leu Ile Ser Gln Phe Val Ser Val Val Val Gln Ser Leu Val Ile Gly 
385                 390                 395                 400 


Ser Leu Phe Tyr Asn Ile Pro Leu Thr Thr Ile Gly Ser Phe Ser Arg 
                405                 410                 415     


Gly Ser Leu Thr Phe Phe Ser Ile Leu Phe Phe Thr Phe Leu Ser Leu 
            420                 425                 430         


Ala Asp Met Pro Ala Ser Phe Gln Arg Gln Pro Val Val Arg Lys His 
        435                 440                 445             


Val Gln Leu His Phe Tyr Tyr Asn Trp Val Glu Thr Leu Ala Thr Asn 
    450                 455                 460                 


Phe Phe Asp Cys Cys Ser Lys Phe Ile Leu Val Val Ile Phe Thr Ile 
465                 470                 475                 480 


Ile Leu Tyr Phe Leu Ala His Leu Gln Tyr Asn Ala Ala Arg Phe Phe 
                485                 490                 495     


Ile Phe Leu Leu Phe Leu Ser Val Tyr Asn Phe Cys Met Val Ser Leu 
            500                 505                 510         


Phe Ala Leu Thr Ala Leu Ile Ala Pro Thr Leu Ser Met Ala Asn Leu 
        515                 520                 525             


Leu Ala Gly Ile Leu Leu Leu Ala Ile Ala Met Tyr Ala Ser Tyr Val 
    530                 535                 540                 


Ile Tyr Met Lys Asp Met His Pro Trp Phe Ile Trp Ile Ala Tyr Leu 
545                 550                 555                 560 


Asn Pro Ala Met Phe Ala Met Glu Ala Ile Leu Ser Asn Glu Leu Phe 
                565                 570                 575     


Asn Leu Lys Leu Asp Cys His Glu Ser Ile Ile Pro Arg Gly Glu Tyr 
            580                 585                 590         


Tyr Asp Asn Ile Ser Phe Ser His Lys Ala Cys Ala Trp Gln Gly Ala 
        595                 600                 605             


Thr Leu Gly Asn Asp Tyr Val Arg Gly Arg Asp Tyr Leu Lys Ser Gly 
    610                 615                 620                 


Leu Lys Tyr Thr Tyr His His Val Trp Arg Asn Phe Gly Ile Ile Ile 
625                 630                 635                 640 


Gly Phe Leu Cys Phe Phe Leu Phe Cys Ser Leu Leu Ala Ala Glu Tyr 
                645                 650                 655     


Ile Thr Pro Leu Phe Thr Arg Glu Asn Leu Leu Arg Trp Asn Asn Tyr 
            660                 665                 670         


Leu Lys Arg Tyr Cys Pro Phe Leu Asn Ser Gln Lys Lys Asn Asn Lys 
        675                 680                 685             


Ser Ala Ile Thr Asn Asn Asp Gly Val Cys Thr Pro Lys Thr Pro Ile 
    690                 695                 700                 


Ala Asn Phe Ser Thr Ser Ser Ser Ser Val Pro Ser Val Ser His Gln 
705                 710                 715                 720 


Tyr Asp Thr Asp Tyr Asn Ile Lys His Pro Asp Glu Thr Val Asn Asn 
                725                 730                 735     


His Thr Lys Glu Ser Val Ala Met Glu Thr Gln Lys His Val Ile Ser 
            740                 745                 750         


Trp Lys Asn Ile Asn Tyr Thr Ile Gly Asp Lys Lys Leu Ile Asn Asp 
        755                 760                 765             


Ala Ser Gly Tyr Ile Ser Ser Gly Leu Thr Ala Leu Met Gly Glu Ser 
    770                 775                 780                 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ser Gln Arg Thr Glu 
785                 790                 795                 800 


Ser Gly Val Val Thr Gly Glu Leu Leu Ile Asp Gly Gln Pro Leu Thr 
                805                 810                 815     


Asn Ile Asp Ala Phe Arg Arg Ser Ile Gly Phe Val Gln Gln Gln Asp 
            820                 825                 830         


Val His Leu Glu Leu Leu Thr Val Arg Glu Ser Leu Glu Ile Ser Cys 
        835                 840                 845             


Val Leu Arg Gly Asp Gly Asp Arg Asp Tyr Leu Gly Val Val Ser Asn 
    850                 855                 860                 


Leu Leu Arg Leu Pro Ser Glu Lys Leu Val Ala Asp Leu Ser Pro Thr 
865                 870                 875                 880 


Gln Arg Lys Leu Leu Ser Ile Gly Val Glu Leu Val Thr Lys Pro Ser 
                885                 890                 895     


Leu Leu Leu Phe Leu Asp Glu Pro Thr Ser Gly Leu Asp Ala Glu Ala 
            900                 905                 910         


Ala Leu Thr Ile Val Gln Phe Leu Lys Lys Leu Ser Met Gln Gly Gln 
        915                 920                 925             


Ala Ile Leu Cys Thr Ile His Gln Pro Ser Lys Ser Val Ile Ser Tyr 
    930                 935                 940                 


Phe Asp Asn Ile Tyr Leu Leu Lys Arg Gly Gly Glu Cys Val Tyr Phe 
945                 950                 955                 960 


Gly Ser Leu Pro Asn Ala Cys Asp Tyr Phe Val Ala His Asp Arg Arg 
                965                 970                 975     


Leu Thr Phe Asp Arg Glu Met Asp Asn Pro Ala Asp Phe Val Ile Asp 
            980                 985                 990         


Val Val Gly Ser Gly Ser Thr Asn  Ile Pro Met Asp Asp  Ala Glu Lys 
        995                 1000                 1005             


Pro Thr  Ser Ser Lys Ile Asp  Glu Pro Val Ser Tyr  His Lys Gln 
    1010                 1015                 1020             


Ser Asp  Ser Ile Asn Trp Ala  Glu Leu Trp Gln Ser  Ser Pro Glu 
    1025                 1030                 1035             


Lys Val  Arg Val Ala Asp Asp  Leu Leu Leu Leu Glu  Glu Glu Ala 
    1040                 1045                 1050             


Arg Lys  Ser Gly Val Asp Phe  Thr Thr Ser Val Trp  Ser Pro Pro 
    1055                 1060                 1065             


Ser Tyr  Met Glu Gln Ile Lys  Leu Ile Thr Lys Arg  Gln Tyr Ile 
    1070                 1075                 1080             


Cys Thr  Lys Arg Asp Met Thr  Tyr Val Phe Ala Lys  Tyr Ala Leu 
    1085                 1090                 1095             


Asn Ala  Gly Ala Gly Leu Phe  Ile Gly Phe Ser Phe  Trp Arg Thr 
    1100                 1105                 1110             


Lys His  Asn Ile Asn Gly Leu  Gln Asp Ala Ile Phe  Leu Cys Phe 
    1115                 1120                 1125             


Met Met  Leu Cys Val Ser Ser  Pro Leu Ile Asn Gln  Val Gln Asp 
    1130                 1135                 1140             


Lys Ala  Leu Gln Ser Lys Glu  Val Tyr Ile Ala Arg  Glu Ala Arg 
    1145                 1150                 1155             


Ser Asn  Thr Tyr His Trp Thr  Val Leu Leu Ile Ala  Gln Thr Ile 
    1160                 1165                 1170             


Val Glu  Leu Pro Leu Ala Ile  Ser Ser Ser Thr Leu  Phe Phe Leu 
    1175                 1180                 1185             


Cys Cys  Tyr Phe Cys Cys Gly  Phe Glu Thr Ser Ala  Arg Val Ala 
    1190                 1195                 1200             


Gly Val  Phe Tyr Leu Asn Tyr  Ile Leu Phe Ser Met  Tyr Tyr Leu 
    1205                 1210                 1215             


Ser Phe  Gly Leu Trp Leu Leu  Tyr Ser Ala Pro Asp  Leu Gln Thr 
    1220                 1225                 1230             


Ala Ala  Val Phe Val Ala Phe  Leu Tyr Ser Phe Thr  Ala Ser Phe 
    1235                 1240                 1245             


Cys Gly  Val Met Gln Pro Tyr  Ser Leu Phe Pro Arg  Phe Trp Thr 
    1250                 1255                 1260             


Phe Met  Tyr Arg Val Ser Pro  Tyr Thr Tyr Phe Ile  Glu Thr Phe 
    1265                 1270                 1275             


Val Ser  Leu Leu Leu His Asp  Arg Glu Val Asn Cys  Ser Thr Ser 
    1280                 1285                 1290             


Glu Met  Val Pro Ser Gln Pro  Val Met Gly Gln Thr  Cys Gly Gln 
    1295                 1300                 1305             


Phe Met  Lys Pro Phe Ile Asp  Glu Phe Gly Gly Lys  Leu His Ile 
    1310                 1315                 1320             


Asn Asn  Thr Tyr Thr Val Cys  Ala Tyr Cys Met Tyr  Thr Val Gly 
    1325                 1330                 1335             


Asp Asp  Phe Leu Ala Gln Glu  Asn Met Ser Tyr His  His Arg Trp 
    1340                 1345                 1350             


Arg Asn  Phe Gly Phe Glu Trp  Val Phe Val Cys Phe  Asn Ile Ala 
    1355                 1360                 1365             


Ala Met  Phe Val Gly Phe Tyr  Leu Thr Tyr Ile Lys  Lys Ile Trp 
    1370                 1375                 1380             


Pro Ser  Val Ile Asp Gly Ile  Lys Lys Cys Ile Pro  Ser Met Arg 
    1385                 1390                 1395             


Arg Ser  Lys Thr Ser His Asn  Pro Asn Glu Gln Ser  Val 
    1400                 1405                 1410     


<210>  16
<211>  1511
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  16

Met Ser Ser Thr Asp Glu His Ile Glu Lys Asp Ile Ser Ser Arg Ser 
1               5                   10                  15      


Asn His Asp Asp Asp Tyr Ala Asn Ser Val Gln Ser Tyr Ala Ala Ser 
            20                  25                  30          


Glu Gly Gln Val Asp Asn Glu Asp Leu Ala Ala Thr Ser Gln Leu Ser 
        35                  40                  45              


Arg His Leu Ser Asn Ile Leu Ser Asn Glu Glu Gly Ile Glu Arg Leu 
    50                  55                  60                  


Glu Ser Met Ala Arg Val Ile Ser His Lys Thr Lys Lys Glu Met Asp 
65                  70                  75                  80  


Ser Phe Glu Ile Asn Asp Leu Asp Phe Asp Leu Arg Ser Leu Leu His 
                85                  90                  95      


Tyr Leu Arg Ser Arg Gln Leu Glu Gln Gly Ile Glu Pro Gly Asp Ser 
            100                 105                 110         


Gly Ile Ala Phe Lys Asn Leu Thr Ala Val Gly Val Asp Ala Ser Ala 
        115                 120                 125             


Ala Tyr Gly Pro Ser Val Glu Glu Met Phe Arg Asn Ile Ala Ser Ile 
    130                 135                 140                 


Pro Ala His Leu Ile Ser Lys Phe Thr Lys Lys Ser Asp Val Pro Leu 
145                 150                 155                 160 


Arg Asn Ile Ile Gln Asn Cys Thr Gly Val Val Glu Ser Gly Glu Met 
                165                 170                 175     


Leu Phe Val Val Gly Arg Pro Gly Ala Gly Cys Ser Thr Phe Leu Lys 
            180                 185                 190         


Cys Leu Ser Gly Glu Thr Ser Glu Leu Val Asp Val Gln Gly Glu Phe 
        195                 200                 205             


Ser Tyr Asp Gly Leu Asp Gln Ser Glu Met Met Ser Lys Tyr Lys Gly 
    210                 215                 220                 


Tyr Val Ile Tyr Cys Pro Glu Leu Asp Phe His Phe Pro Lys Ile Thr 
225                 230                 235                 240 


Val Lys Glu Thr Ile Asp Phe Ala Leu Lys Cys Lys Thr Pro Arg Val 
                245                 250                 255     


Arg Ile Asp Lys Met Thr Arg Lys Gln Tyr Val Asp Asn Ile Arg Asp 
            260                 265                 270         


Met Trp Cys Thr Val Phe Gly Leu Arg His Thr Tyr Ala Thr Lys Val 
        275                 280                 285             


Gly Asn Asp Phe Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val 
    290                 295                 300                 


Ser Leu Val Glu Ala Gln Ala Met Asn Ala Ser Ile Tyr Ser Trp Asp 
305                 310                 315                 320 


Asn Ala Thr Arg Gly Leu Asp Ala Ser Thr Ala Leu Glu Phe Ala Gln 
                325                 330                 335     


Ala Ile Arg Thr Ala Thr Asn Met Val Asn Asn Ser Ala Ile Val Ala 
            340                 345                 350         


Ile Tyr Gln Ala Gly Glu Asn Ile Tyr Glu Leu Phe Asp Lys Thr Thr 
        355                 360                 365             


Val Leu Tyr Asn Gly Arg Gln Ile Tyr Phe Gly Pro Ala Asp Lys Ala 
    370                 375                 380                 


Val Gly Tyr Phe Gln Arg Met Gly Trp Val Lys Pro Asn Arg Met Thr 
385                 390                 395                 400 


Ser Ala Glu Phe Leu Thr Ser Val Thr Val Asp Phe Glu Asn Arg Thr 
                405                 410                 415     


Leu Asp Ile Lys Pro Gly Tyr Glu Asp Lys Val Pro Lys Ser Ser Ser 
            420                 425                 430         


Glu Phe Glu Glu Tyr Trp Leu Asn Ser Glu Asp Tyr Gln Glu Leu Leu 
        435                 440                 445             


Arg Thr Tyr Asp Asp Tyr Gln Ser Arg His Pro Val Asn Glu Thr Arg 
    450                 455                 460                 


Asp Arg Leu Asp Val Ala Lys Lys Gln Arg Leu Gln Gln Gly Gln Arg 
465                 470                 475                 480 


Glu Asn Ser Gln Tyr Val Val Asn Tyr Trp Thr Gln Val Tyr Tyr Cys 
                485                 490                 495     


Met Ile Arg Gly Phe Gln Arg Val Lys Gly Asp Ser Thr Tyr Thr Lys 
            500                 505                 510         


Val Tyr Leu Ser Ser Phe Leu Ile Lys Ala Leu Ile Ile Gly Ser Met 
        515                 520                 525             


Phe His Lys Ile Asp Asp Lys Ser Gln Ser Thr Thr Ala Gly Ala Tyr 
    530                 535                 540                 


Ser Arg Gly Gly Met Leu Phe Tyr Val Leu Leu Phe Ala Ser Val Thr 
545                 550                 555                 560 


Ser Leu Ala Glu Ile Gly Asn Ser Phe Ser Ser Arg Pro Val Ile Val 
                565                 570                 575     


Lys His Lys Ser Tyr Ser Met Tyr His Leu Ser Ala Glu Ser Leu Gln 
            580                 585                 590         


Glu Ile Ile Thr Glu Phe Pro Thr Lys Phe Val Ala Ile Val Ile Leu 
        595                 600                 605             


Cys Leu Ile Thr Tyr Trp Ile Pro Phe Met Lys Tyr Glu Ala Gly Ala 
    610                 615                 620                 


Phe Phe Gln Tyr Ile Leu Tyr Leu Leu Thr Val Gln Gln Cys Thr Ser 
625                 630                 635                 640 


Phe Ile Phe Lys Phe Val Ala Thr Met Ser Lys Ser Gly Val Asp Ala 
                645                 650                 655     


His Ala Val Gly Gly Leu Trp Val Leu Met Leu Cys Val Tyr Ala Gly 
            660                 665                 670         


Phe Val Leu Pro Ile Gly Glu Met His His Trp Ile Arg Trp Leu His 
        675                 680                 685             


Phe Ile Asn Pro Leu Thr Tyr Ala Phe Glu Ser Leu Val Ser Thr Glu 
    690                 695                 700                 


Phe His His Arg Glu Met Leu Cys Ser Ala Leu Val Pro Ser Gly Pro 
705                 710                 715                 720 


Gly Tyr Glu Gly Ile Ser Ile Ala Asn Gln Val Cys Asp Ala Ala Gly 
                725                 730                 735     


Ala Val Lys Gly Asn Leu Tyr Val Ser Gly Asp Ser Tyr Ile Leu His 
            740                 745                 750         


Gln Tyr His Phe Ala Tyr Lys His Ala Trp Arg Asn Trp Gly Val Asn 
        755                 760                 765             


Ile Val Trp Thr Phe Gly Tyr Ile Val Phe Asn Val Ile Leu Ser Glu 
    770                 775                 780                 


Tyr Leu Lys Pro Val Glu Gly Gly Gly Asp Leu Leu Leu Tyr Lys Arg 
785                 790                 795                 800 


Gly His Met Pro Glu Leu Gly Thr Glu Asn Ala Asp Ala Arg Thr Ala 
                805                 810                 815     


Ser Arg Glu Glu Met Met Glu Ala Leu Asn Gly Pro Asn Val Asp Leu 
            820                 825                 830         


Glu Lys Val Ile Ala Glu Lys Asp Val Phe Thr Trp Asn His Leu Asp 
        835                 840                 845             


Tyr Thr Ile Pro Tyr Asp Gly Ala Thr Arg Lys Leu Leu Ser Asp Val 
    850                 855                 860                 


Phe Gly Tyr Val Lys Pro Gly Lys Met Thr Ala Leu Met Gly Glu Ser 
865                 870                 875                 880 


Gly Ala Gly Lys Thr Thr Leu Leu Asn Val Leu Ala Gln Arg Ile Asn 
                885                 890                 895     


Met Gly Val Ile Thr Gly Asp Met Leu Val Asn Ala Lys Pro Leu Pro 
            900                 905                 910         


Ala Ser Phe Asn Arg Ser Cys Gly Tyr Val Ala Gln Ala Asp Asn His 
        915                 920                 925             


Met Ala Glu Leu Ser Val Arg Glu Ser Leu Arg Phe Ala Ala Glu Leu 
    930                 935                 940                 


Arg Gln Gln Ser Ser Val Pro Leu Glu Glu Lys Tyr Glu Tyr Val Glu 
945                 950                 955                 960 


Lys Ile Ile Thr Leu Leu Gly Met Gln Asn Tyr Ala Glu Ala Leu Val 
                965                 970                 975     


Gly Lys Thr Gly Arg Gly Leu Asn Val Glu Gln Arg Lys Lys Leu Ser 
            980                 985                 990         


Ile Gly Val Glu Leu Val Ala Lys  Pro Ser Leu Leu Leu  Phe Leu Asp 
        995                 1000                 1005             


Glu Pro  Thr Ser Gly Leu Asp  Ser Gln Ser Ala Trp  Ser Ile Val 
    1010                 1015                 1020             


Gln Phe  Met Arg Ala Leu Ala  Asp Ser Gly Gln Ser  Ile Leu Cys 
    1025                 1030                 1035             


Thr Ile  His Gln Pro Ser Ala  Thr Leu Phe Glu Gln  Phe Asp Arg 
    1040                 1045                 1050             


Leu Leu  Leu Leu Lys Lys Gly  Gly Lys Met Val Tyr  Phe Gly Asp 
    1055                 1060                 1065             


Ile Gly  Pro Asn Ser Glu Thr  Leu Leu Lys Tyr Phe  Glu Arg Gln 
    1070                 1075                 1080             


Ser Gly  Met Lys Cys Gly Val  Ser Glu Asn Pro Ala  Glu Tyr Ile 
    1085                 1090                 1095             


Leu Asn  Cys Ile Gly Ala Gly  Ala Thr Ala Ser Val  Asn Ser Asp 
    1100                 1105                 1110             


Trp His  Asp Leu Trp Leu Ala  Ser Pro Glu Cys Ala  Ala Ala Arg 
    1115                 1120                 1125             


Ala Glu  Val Glu Glu Leu His  Arg Thr Leu Pro Gly  Arg Ala Val 
    1130                 1135                 1140             


Asn Asp  Asp Pro Glu Leu Ala  Thr Arg Phe Ala Ala  Ser Tyr Met 
    1145                 1150                 1155             


Thr Gln  Ile Lys Cys Val Leu  Arg Arg Thr Ala Leu  Gln Phe Trp 
    1160                 1165                 1170             


Arg Ser  Pro Val Tyr Ile Arg  Ala Lys Phe Phe Glu  Cys Val Ala 
    1175                 1180                 1185             


Cys Ala  Leu Phe Val Gly Leu  Ser Tyr Val Gly Val  Asn His Ser 
    1190                 1195                 1200             


Val Gly  Gly Ala Ile Glu Ala  Phe Ser Ser Ile Phe  Met Leu Leu 
    1205                 1210                 1215             


Leu Ile  Ala Leu Ala Met Ile  Asn Gln Leu His Val  Phe Ala Tyr 
    1220                 1225                 1230             


Asp Ser  Arg Glu Leu Tyr Glu  Val Arg Glu Ala Ala  Ser Asn Thr 
    1235                 1240                 1245             


Phe His  Trp Ser Val Leu Leu  Leu Cys His Ala Ala  Val Glu Asn 
    1250                 1255                 1260             


Phe Trp  Ser Thr Leu Cys Gln  Phe Met Cys Phe Ile  Cys Tyr Tyr 
    1265                 1270                 1275             


Trp Pro  Ala Gln Phe Ser Gly  Arg Ala Ser His Ala  Gly Phe Phe 
    1280                 1285                 1290             


Phe Phe  Phe Tyr Val Leu Ile  Phe Pro Leu Tyr Phe  Val Thr Tyr 
    1295                 1300                 1305             


Gly Leu  Trp Ile Leu Tyr Met  Ser Pro Asp Val Pro  Ser Ala Ser 
    1310                 1315                 1320             


Met Ile  Asn Ser Asn Leu Phe  Ala Ala Met Leu Leu  Phe Cys Gly 
    1325                 1330                 1335             


Ile Leu  Gln Pro Arg Glu Lys  Met Pro Ala Phe Trp  Arg Arg Leu 
    1340                 1345                 1350             


Met Tyr  Asn Val Ser Pro Phe  Thr Tyr Val Val Gln  Ala Leu Val 
    1355                 1360                 1365             


Thr Pro  Leu Val His Asn Lys  Lys Val Val Cys Asn  Pro His Glu 
    1370                 1375                 1380             


Tyr Asn  Ile Met Asp Pro Pro  Ser Gly Lys Thr Cys  Gly Glu Phe 
    1385                 1390                 1395             


Leu Ser  Thr Tyr Met Asp Asn  Asn Thr Gly Tyr Leu  Val Asn Pro 
    1400                 1405                 1410             


Thr Ala  Thr Glu Asn Cys Gln  Tyr Cys Pro Tyr Thr  Val Gln Asp 
    1415                 1420                 1425             


Gln Val  Val Ala Lys Tyr Asn  Val Lys Trp Asp His  Arg Trp Arg 
    1430                 1435                 1440             


Asn Phe  Gly Phe Met Trp Ala  Tyr Ile Cys Phe Asn  Ile Ala Ala 
    1445                 1450                 1455             


Met Leu  Ile Cys Tyr Tyr Val  Val Arg Val Lys Val  Trp Ser Leu 
    1460                 1465                 1470             


Lys Ser  Val Leu Asn Phe Lys  Lys Trp Phe Asn Gly  Pro Arg Lys 
    1475                 1480                 1485             


Glu Arg  His Glu Lys Asp Thr  Asn Ile Phe Gln Thr  Val Pro Gly 
    1490                 1495                 1500             


Asp Glu  Asn Lys Ile Thr Lys  Lys 
    1505                 1510     


<210>  17
<211>  1529
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Ser Ser Asp Ile Arg Asp Val Glu Glu Arg Asn Ser Arg Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Asn Ser Ala Ala Gln Ser Ile Gly Gln His 
            20                  25                  30          


Pro Tyr Arg Gly Phe Asp Ser Glu Ala Ala Glu Arg Val His Glu Leu 
        35                  40                  45              


Ala Arg Thr Leu Thr Ser Gln Ser Leu Leu Tyr Thr Ala Asn Ser Asn 
    50                  55                  60                  


Asn Ser Ser Ser Ser Asn His Asn Ala His Asn Ala Asp Ser Arg Ser 
65                  70                  75                  80  


Val Phe Ser Thr Asp Met Glu Gly Val Asn Pro Val Phe Thr Asn Pro 
                85                  90                  95      


Asp Thr Pro Gly Tyr Asn Pro Lys Leu Asp Pro Asn Ser Asp Gln Phe 
            100                 105                 110         


Ser Ser Thr Ala Trp Val Gln Asn Met Ala Asn Ile Cys Thr Ser Asp 
        115                 120                 125             


Pro Asp Phe Tyr Lys Pro Tyr Ser Leu Gly Cys Val Trp Lys Asn Leu 
    130                 135                 140                 


Ser Ala Ser Gly Asp Ser Ala Asp Val Ser Tyr Gln Ser Thr Phe Ala 
145                 150                 155                 160 


Asn Ile Val Pro Lys Leu Leu Thr Lys Gly Leu Arg Leu Leu Lys Pro 
                165                 170                 175     


Ser Lys Glu Glu Asp Thr Phe Gln Ile Leu Lys Pro Met Asp Gly Cys 
            180                 185                 190         


Leu Asn Pro Gly Glu Leu Leu Val Val Leu Gly Arg Pro Gly Ser Gly 
        195                 200                 205             


Cys Thr Thr Leu Leu Lys Ser Ile Ser Ser Asn Ser His Gly Phe Lys 
    210                 215                 220                 


Ile Ala Lys Asp Ser Ile Val Ser Tyr Asn Gly Leu Ser Ser Ser Asp 
225                 230                 235                 240 


Ile Arg Lys His Tyr Arg Gly Glu Val Val Tyr Asn Ala Glu Ser Asp 
                245                 250                 255     


Ile His Leu Pro His Leu Thr Val Tyr Gln Thr Leu Phe Thr Val Ala 
            260                 265                 270         


Arg Met Lys Thr Pro Gln Asn Arg Ile Lys Gly Val Asp Arg Glu Ala 
        275                 280                 285             


Tyr Ala Asn His Val Thr Glu Val Ala Met Ala Thr Tyr Gly Leu Ser 
    290                 295                 300                 


His Thr Arg Asp Thr Lys Val Gly Asn Asp Leu Val Arg Gly Val Ser 
305                 310                 315                 320 


Gly Gly Glu Arg Lys Arg Val Ser Ile Ala Glu Val Ala Ile Cys Gly 
                325                 330                 335     


Ala Arg Phe Gln Cys Trp Asp Asn Ala Thr Arg Gly Leu Asp Ser Ala 
            340                 345                 350         


Thr Ala Leu Glu Phe Ile Arg Ala Leu Lys Thr Gln Ala Asp Ile Gly 
        355                 360                 365             


Lys Thr Ala Ala Thr Val Ala Ile Tyr Gln Cys Ser Gln Asp Ala Tyr 
    370                 375                 380                 


Asp Leu Phe Asp Lys Val Cys Val Leu Asp Asp Gly Tyr Gln Leu Tyr 
385                 390                 395                 400 


Phe Gly Pro Ala Lys Asp Ala Lys Lys Tyr Phe Gln Asp Met Gly Tyr 
                405                 410                 415     


Tyr Cys Pro Pro Arg Gln Thr Thr Ala Asp Phe Leu Thr Ser Ile Thr 
            420                 425                 430         


Ser Pro Thr Glu Arg Ile Ile Ser Lys Glu Phe Ile Glu Lys Gly Thr 
        435                 440                 445             


Arg Val Pro Gln Thr Pro Lys Asp Met Ala Glu Tyr Trp Leu Gln Ser 
    450                 455                 460                 


Glu Ser Tyr Lys Asn Leu Ile Lys Asp Ile Asp Ser Thr Leu Glu Lys 
465                 470                 475                 480 


Asn Thr Asp Glu Ala Arg Asn Ile Ile Arg Asp Ala His His Ala Lys 
                485                 490                 495     


Gln Ala Lys Arg Ala Pro Pro Ser Ser Pro Tyr Val Val Asn Tyr Gly 
            500                 505                 510         


Met Gln Val Lys Tyr Leu Leu Ile Arg Asn Phe Trp Arg Met Lys Gln 
        515                 520                 525             


Ser Ala Ser Val Thr Leu Trp Gln Val Ile Gly Asn Ser Val Met Ala 
    530                 535                 540                 


Phe Ile Leu Gly Ser Met Phe Tyr Lys Val Met Lys Lys Asn Asp Thr 
545                 550                 555                 560 


Ser Thr Phe Tyr Phe Arg Gly Ala Ala Met Phe Phe Ala Ile Leu Phe 
                565                 570                 575     


Asn Ala Phe Ser Cys Leu Leu Glu Ile Phe Ser Leu Tyr Glu Thr Arg 
            580                 585                 590         


Pro Ile Thr Glu Lys His Arg Thr Tyr Ser Leu Tyr His Pro Ser Ala 
        595                 600                 605             


Asp Ala Phe Ala Ser Val Leu Ser Glu Met Pro Pro Lys Leu Ile Thr 
    610                 615                 620                 


Ala Val Cys Phe Asn Ile Ile Phe Tyr Phe Leu Val Asp Phe Arg Arg 
625                 630                 635                 640 


Asn Gly Gly Val Phe Phe Phe Tyr Phe Leu Ile Asn Val Ile Ala Thr 
                645                 650                 655     


Phe Thr Leu Ser His Leu Phe Arg Cys Val Gly Ser Leu Thr Lys Thr 
            660                 665                 670         


Leu Gln Glu Ala Met Val Pro Ala Ser Met Leu Leu Leu Ala Ile Ser 
        675                 680                 685             


Met Tyr Thr Gly Phe Ala Ile Pro Lys Thr Lys Ile Leu Gly Trp Ser 
    690                 695                 700                 


Ile Trp Ile Trp Tyr Ile Asn Pro Leu Ala Tyr Leu Phe Glu Ser Leu 
705                 710                 715                 720 


Met Ile Asn Glu Phe His Asp Arg Arg Phe Pro Cys Ala Gln Tyr Ile 
                725                 730                 735     


Pro Ala Gly Pro Ala Tyr Gln Asn Ile Thr Gly Thr Gln Arg Val Cys 
            740                 745                 750         


Ser Ala Val Gly Ala Tyr Pro Gly Asn Asp Tyr Val Leu Gly Asp Asp 
        755                 760                 765             


Phe Leu Lys Glu Ser Tyr Asp Tyr Glu His Lys His Lys Trp Arg Gly 
    770                 775                 780                 


Phe Gly Ile Gly Met Ala Tyr Val Val Phe Phe Phe Phe Val Tyr Leu 
785                 790                 795                 800 


Ile Leu Cys Glu Tyr Asn Glu Gly Ala Lys Gln Lys Gly Glu Met Val 
                805                 810                 815     


Val Phe Leu Arg Ser Lys Ile Lys Gln Leu Lys Lys Glu Gly Lys Leu 
            820                 825                 830         


Gln Glu Lys His Arg Pro Gly Asp Ile Glu Asn Asn Ala Gly Ser Ser 
        835                 840                 845             


Pro Asp Ser Ala Thr Thr Glu Lys Lys Ile Leu Asp Asp Ser Ser Glu 
    850                 855                 860                 


Gly Ser Asp Ser Ser Ser Asp Asn Ala Gly Leu Gly Leu Ser Lys Ser 
865                 870                 875                 880 


Glu Ala Ile Phe His Trp Arg Asp Leu Cys Tyr Asp Val Pro Ile Lys 
                885                 890                 895     


Gly Gly Gln Arg Arg Ile Leu Asn Asn Val Asp Gly Trp Val Lys Pro 
            900                 905                 910         


Gly Thr Leu Thr Ala Leu Met Gly Ala Ser Gly Ala Gly Lys Thr Thr 
        915                 920                 925             


Leu Leu Asp Cys Leu Ala Glu Arg Val Thr Met Gly Val Ile Thr Gly 
    930                 935                 940                 


Asn Ile Phe Val Asp Gly Arg Leu Arg Asp Glu Ser Phe Pro Arg Ser 
945                 950                 955                 960 


Ile Gly Tyr Cys Gln Gln Gln Asp Leu His Leu Lys Thr Ala Thr Val 
                965                 970                 975     


Arg Glu Ser Leu Arg Phe Ser Ala Tyr Leu Arg Gln Pro Ser Ser Val 
            980                 985                 990         


Ser Ile Glu Glu Lys Asn Arg Tyr  Val Glu Glu Val Ile  Lys Ile Leu 
        995                 1000                 1005             


Glu Met  Gln Gln Tyr Ser Asp  Ala Val Val Gly Val  Ala Gly Glu 
    1010                 1015                 1020             


Gly Leu  Asn Val Glu Gln Arg  Lys Arg Leu Thr Ile  Gly Val Glu 
    1025                 1030                 1035             


Leu Ala  Ala Arg Pro Lys Leu  Leu Val Phe Leu Asp  Glu Pro Thr 
    1040                 1045                 1050             


Ser Gly  Leu Asp Ser Gln Thr  Ala Trp Asp Thr Cys  Gln Leu Met 
    1055                 1060                 1065             


Arg Lys  Leu Ala Thr His Gly  Gln Ala Ile Leu Cys  Thr Ile His 
    1070                 1075                 1080             


Gln Pro  Ser Ala Ile Leu Met  Gln Gln Phe Asp Arg  Leu Leu Phe 
    1085                 1090                 1095             


Leu Gln  Lys Gly Gly Gln Thr  Val Tyr Phe Gly Asp  Leu Gly Glu 
    1100                 1105                 1110             


Gly Cys  Lys Thr Met Ile Asp  Tyr Phe Glu Ser Lys  Gly Ala His 
    1115                 1120                 1125             


Lys Cys  Pro Pro Asp Ala Asn  Pro Ala Glu Trp Met  Leu Glu Val 
    1130                 1135                 1140             


Val Gly  Ala Ala Pro Gly Ser  His Ala Thr Gln Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Val Trp  Arg Asn Ser Asp Glu  Tyr Lys Ala Val Gln  Glu Glu Leu 
    1160                 1165                 1170             


Asp Trp  Met Glu Lys Asn Leu  Pro Gly Arg Ser Lys  Glu Pro Thr 
    1175                 1180                 1185             


Ala Glu  Glu His Lys Pro Phe  Ala Ala Ser Leu Tyr  Tyr Gln Phe 
    1190                 1195                 1200             


Lys Met  Val Thr Ile Arg Leu  Phe Gln Gln Tyr Trp  Arg Ser Pro 
    1205                 1210                 1215             


Asp Tyr  Leu Trp Ser Lys Phe  Ile Leu Thr Ile Phe  Asn Gln Val 
    1220                 1225                 1230             


Phe Ile  Gly Phe Thr Phe Phe  Lys Ala Asp Arg Ser  Leu Gln Gly 
    1235                 1240                 1245             


Leu Gln  Asn Gln Met Leu Ser  Ile Phe Met Tyr Thr  Val Ile Phe 
    1250                 1255                 1260             


Asn Pro  Ile Leu Gln Gln Tyr  Leu Pro Ser Phe Val  Gln Gln Arg 
    1265                 1270                 1275             


Asp Leu  Tyr Glu Ala Arg Glu  Arg Pro Ser Arg Thr  Phe Ser Trp 
    1280                 1285                 1290             


Leu Ala  Phe Phe Leu Ser Gln  Ile Ile Val Glu Ile  Pro Trp Asn 
    1295                 1300                 1305             


Ile Leu  Ala Gly Thr Ile Ala  Tyr Cys Ile Tyr Tyr  Tyr Ala Val 
    1310                 1315                 1320             


Gly Phe  Tyr Ala Asn Ala Ser  Ala Ala Gly Gln Leu  His Glu Arg 
    1325                 1330                 1335             


Gly Ala  Leu Phe Trp Leu Phe  Ser Ile Ala Phe Tyr  Val Tyr Ile 
    1340                 1345                 1350             


Gly Ser  Met Gly Leu Leu Met  Ile Ser Phe Asn Glu  Val Ala Glu 
    1355                 1360                 1365             


Thr Ala  Ala His Met Gly Thr  Leu Leu Phe Thr Met  Ala Leu Ser 
    1370                 1375                 1380             


Phe Cys  Gly Val Met Ala Thr  Pro Lys Val Met Pro  Arg Phe Trp 
    1385                 1390                 1395             


Ile Phe  Met Tyr Arg Val Ser  Pro Leu Thr Tyr Met  Ile Asp Ala 
    1400                 1405                 1410             


Leu Leu  Ala Leu Gly Val Ala  Asn Val Asp Val Lys  Cys Ser Asn 
    1415                 1420                 1425             


Tyr Glu  Met Val Lys Phe Thr  Pro Pro Ser Gly Thr  Thr Cys Gly 
    1430                 1435                 1440             


Asp Tyr  Met Ala Ser Tyr Ile  Lys Leu Ala Gly Thr  Gly Tyr Leu 
    1445                 1450                 1455             


Ser Asp  Pro Ser Ala Thr Asp  Ile Cys Ser Phe Cys  Ala Val Ser 
    1460                 1465                 1470             


Thr Thr  Asn Ala Phe Leu Ala  Thr Phe Ser Ser His  Tyr Tyr Arg 
    1475                 1480                 1485             


Arg Trp  Arg Asn Tyr Gly Ile  Phe Ile Cys Tyr Ile  Ala Phe Asp 
    1490                 1495                 1500             


Tyr Ile  Ala Ala Thr Phe Leu  Tyr Trp Leu Ser Arg  Val Pro Lys 
    1505                 1510                 1515             


Lys Asn  Gly Lys Ile Ser Glu  Lys Pro Lys Lys 
    1520                 1525                 


<210>  18
<211>  1333
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  18

Met Glu Cys Val Ser Val Glu Gly Leu Asp Ser Ser Phe Leu Glu Gly 
1               5                   10                  15      


Gln Thr Phe Gly Asp Ile Leu Cys Leu Pro Trp Thr Ile Ile Lys Gly 
            20                  25                  30          


Ile Arg Glu Arg Lys Asn Arg Asn Lys Met Lys Ile Ile Leu Lys Asn 
        35                  40                  45              


Val Ser Leu Leu Ala Lys Ser Gly Glu Met Val Leu Val Leu Gly Arg 
    50                  55                  60                  


Pro Gly Ala Gly Cys Thr Ser Phe Leu Lys Ser Ala Ala Gly Glu Thr 
65                  70                  75                  80  


Ser Gln Phe Ala Gly Gly Val Thr Thr Gly His Ile Ser Tyr Asp Gly 
                85                  90                  95      


Ile Pro Gln Lys Glu Met Met Gln His Tyr Lys Pro Asp Val Ile Tyr 
            100                 105                 110         


Asn Gly Glu Gln Asp Val His Phe Pro His Leu Thr Val Lys Gln Thr 
        115                 120                 125             


Leu Asp Phe Ala Ile Ser Cys Lys Met Pro Ala Lys Arg Val Asn Asn 
    130                 135                 140                 


Val Thr Lys Glu Glu Tyr Ile Thr Ala Asn Arg Glu Phe Tyr Ala Lys 
145                 150                 155                 160 


Ile Phe Gly Leu Thr His Thr Phe Asp Thr Lys Val Gly Asn Asp Phe 
                165                 170                 175     


Ile Ser Gly Val Ser Gly Gly Glu Arg Lys Arg Val Ser Ile Ala Glu 
            180                 185                 190         


Ala Leu Ala Ala Lys Gly Ser Ile Tyr Cys Trp Asp Asn Ala Thr Arg 
        195                 200                 205             


Gly Leu Asp Ser Ser Thr Ala Leu Glu Phe Ala Arg Ala Ile Arg Thr 
    210                 215                 220                 


Met Thr Asn Leu Leu Gly Thr Thr Ala Leu Val Thr Val Tyr Gln Ala 
225                 230                 235                 240 


Ser Glu Asn Ile Tyr Glu Thr Phe Asp Lys Val Thr Val Leu Tyr Ala 
                245                 250                 255     


Gly Arg Gln Ile Phe Cys Gly Lys Thr Thr Glu Ala Lys Asp Tyr Phe 
            260                 265                 270         


Glu Asn Met Gly Tyr Leu Cys Pro Pro Arg Gln Ser Thr Ala Glu Tyr 
        275                 280                 285             


Leu Thr Ala Ile Thr Asp Pro Asn Gly Leu His Glu Ile Lys Pro Gly 
    290                 295                 300                 


Phe Glu Tyr Gln Val Pro His Thr Ala Asp Glu Phe Glu Lys Tyr Trp 
305                 310                 315                 320 


Leu Asp Ser Pro Glu Tyr Ala Arg Leu Lys Gly Glu Ile Gln Lys Tyr 
                325                 330                 335     


Lys His Glu Val Asn Thr Glu Trp Thr Lys Lys Thr Tyr Asn Glu Ser 
            340                 345                 350         


Met Ala Gln Glu Lys Ser Lys Gly Thr Arg Lys Lys Ser Tyr Tyr Thr 
        355                 360                 365             


Val Ser Tyr Trp Glu Gln Ile Arg Leu Cys Thr Ile Arg Gly Phe Leu 
    370                 375                 380                 


Arg Ile Tyr Gly Asp Lys Ser Tyr Thr Val Ile Asn Thr Cys Ala Ala 
385                 390                 395                 400 


Ile Ala Gln Ala Phe Ile Thr Gly Ser Leu Phe Tyr Gln Ala Pro Ser 
                405                 410                 415     


Ser Thr Leu Gly Ala Phe Ser Arg Ser Gly Val Leu Phe Phe Ser Leu 
            420                 425                 430         


Leu Tyr Tyr Ser Leu Met Gly Leu Ala Asn Ile Ser Phe Glu His Arg 
        435                 440                 445             


Pro Ile Leu Gln Lys His Lys Val Tyr Ser Leu Tyr His Pro Ser Ala 
    450                 455                 460                 


Glu Ala Leu Ala Ser Thr Ile Ser Ser Phe Pro Phe Arg Met Ile Gly 
465                 470                 475                 480 


Leu Thr Phe Phe Ile Ile Ile Leu Tyr Phe Leu Ala Gly Leu His Arg 
                485                 490                 495     


Ser Ala Gly Ala Phe Phe Thr Met Tyr Leu Leu Leu Thr Met Cys Ser 
            500                 505                 510         


Glu Ala Ile Thr Ser Leu Phe Gln Met Val Ser Ser Leu Cys Asp Thr 
        515                 520                 525             


Leu Ser Gln Ala Asn Ser Ile Ala Gly Val Val Met Leu Ser Ile Ala 
    530                 535                 540                 


Met Tyr Ser Thr Tyr Met Ile Gln Leu Pro Ser Met His Pro Trp Phe 
545                 550                 555                 560 


Lys Trp Ile Ser Tyr Ile Leu Pro Ile Arg Tyr Ala Phe Glu Ser Met 
                565                 570                 575     


Leu Asn Ala Glu Phe His Gly Arg His Met Asp Cys Gly Gly Thr Leu 
            580                 585                 590         


Val Pro Ser Gly Pro Gly Phe Glu Asn Ile Leu Pro Glu Asn Gln Val 
        595                 600                 605             


Cys Ala Phe Val Gly Ser Arg Pro Gly Gln Ser Trp Val Leu Gly Asp 
    610                 615                 620                 


Asp Tyr Leu Arg Ala Gln Tyr Gln Tyr Glu Tyr Lys Asn Thr Trp Arg 
625                 630                 635                 640 


Asn Phe Gly Ile Met Trp Cys Phe Leu Ile Gly Tyr Ile Val Leu Arg 
                645                 650                 655     


Ala Val Phe Thr Glu Tyr Lys Ser Pro Val Lys Ser Gly Gly Asp Ala 
            660                 665                 670         


Leu Val Val Lys Lys Gly Thr Lys Asn Ala Ile Gln Arg Ser Trp Ser 
        675                 680                 685             


Ser Lys Asn Asp Glu Glu Asn Leu Asn Ala Ser Ile Ala Thr Gln Asp 
    690                 695                 700                 


Met Lys Glu Ile Ala Ser Ser Asn Asp Asp Ser Thr Ser Ala Asp Phe 
705                 710                 715                 720 


Glu Gly Leu Glu Ser Thr Gly Val Phe Ile Trp Lys Asn Val Ser Phe 
                725                 730                 735     


Thr Ile Pro His Ser Ser Gly Gln Arg Lys Leu Leu Asp Ser Val Ser 
            740                 745                 750         


Gly Tyr Cys Val Pro Gly Thr Leu Thr Ala Leu Ile Gly Glu Ser Gly 
        755                 760                 765             


Ala Gly Lys Thr Thr Leu Leu Asn Thr Leu Ala Gln Arg Asn Val Gly 
    770                 775                 780                 


Thr Ile Thr Gly Asp Met Leu Val Asp Gly Leu Pro Met Asp Ala Ser 
785                 790                 795                 800 


Phe Lys Arg Arg Thr Gly Tyr Val Gln Gln Gln Asp Leu His Val Ala 
                805                 810                 815     


Glu Leu Thr Val Lys Glu Ser Leu Gln Phe Ser Ala Arg Met Arg Arg 
            820                 825                 830         


Pro Gln Ser Ile Pro Asp Ala Glu Lys Met Glu Tyr Val Glu Lys Ile 
        835                 840                 845             


Ile Ser Ile Leu Glu Met Gln Glu Phe Ser Glu Ala Leu Val Gly Glu 
    850                 855                 860                 


Ile Gly Tyr Gly Leu Asn Val Glu Gln Arg Lys Lys Leu Ser Ile Gly 
865                 870                 875                 880 


Val Glu Leu Val Gly Lys Pro Asp Leu Leu Leu Phe Leu Asp Glu Pro 
                885                 890                 895     


Thr Ser Gly Leu Asp Ser Gln Ser Ala Trp Ala Val Val Lys Met Leu 
            900                 905                 910         


Lys Arg Leu Ala Leu Ala Gly Gln Ser Ile Leu Cys Thr Ile His Gln 
        915                 920                 925             


Pro Ser Ala Thr Leu Phe Glu Gln Phe Asp Arg Leu Leu Leu Leu Gly 
    930                 935                 940                 


Lys Gly Gly Gln Thr Ile Tyr Phe Gly Glu Ile Gly Lys Asn Ser Ser 
945                 950                 955                 960 


Ser Val Ile Lys Tyr Phe Glu Lys Asn Gly Ala Arg Lys Cys Gln Gln 
                965                 970                 975     


Asn Glu Asn Pro Ala Glu Tyr Ile Leu Glu Ala Ile Gly Ala Gly Ala 
            980                 985                 990         


Thr Ala Ser Val Gln Gln Asn Trp  Pro Asp Ile Trp Gln  Lys Ser His 
        995                 1000                 1005             


Glu Tyr  Ala Asn Ile Asn Glu  Lys Ile Asn Asp Met  Ile Lys Asp 
    1010                 1015                 1020             


Leu Ser  Ser Thr Thr Leu His  Lys Thr Ala Thr Arg  Ala Ser Lys 
    1025                 1030                 1035             


Tyr Ala  Thr Ser Tyr Ser Tyr  Gln Phe His His Val  Leu Lys Arg 
    1040                 1045                 1050             


Ser Ser  Leu Thr Phe Trp Arg  Asn Leu Asn Tyr Ile  Met Ala Lys 
    1055                 1060                 1065             


Met Met  Leu Leu Met Ile Ser  Gly Leu Phe Ile Gly  Phe Thr Phe 
    1070                 1075                 1080             


Phe His  Val Gly Val Asn Ala  Ile Gly Leu Gln Asn  Ser Leu Phe 
    1085                 1090                 1095             


Ala Cys  Phe Met Ala Ile Val  Ile Ser Ala Pro Ala  Thr Asn Gln 
    1100                 1105                 1110             


Ile Gln  Glu Arg Ala Thr Val  Ala Lys Glu Leu Tyr  Glu Val Arg 
    1115                 1120                 1125             


Glu Ser  Lys Ser Asn Met Phe  His Trp Ser Leu Leu  Leu Ile Thr 
    1130                 1135                 1140             


His Tyr  Leu Asn Glu Leu Pro  Tyr His Leu Leu Phe  Ser Thr Ile 
    1145                 1150                 1155             


Phe Phe  Val Ser Ser Tyr Phe  Pro Leu Gly Val Phe  Thr Glu Ala 
    1160                 1165                 1170             


Ser Arg  Ser Ser Val Phe Tyr  Leu Asn Tyr Ala Ile  Leu Phe Gln 
    1175                 1180                 1185             


Leu Tyr  Tyr Ile Gly Leu Ala  Leu Met Ile Leu Tyr  Met Ser Pro 
    1190                 1195                 1200             


Asn Leu  Gln Ser Ala Asn Val  Ile Val Gly Phe Ile  Leu Ser Phe 
    1205                 1210                 1215             


Leu Leu  Ser Phe Cys Gly Ala  Val Gln Pro Ala Ser  Leu Met Pro 
    1220                 1225                 1230             


Gly Phe  Trp Thr Phe Met Trp  Lys Leu Ser Pro Tyr  Thr Tyr Phe 
    1235                 1240                 1245             


Leu Gln  Asn Leu Val Gly Leu  Leu Met His Asp Lys  Pro Val Arg 
    1250                 1255                 1260             


Cys Ser  Lys Lys Glu Leu Ser  Leu Phe Asn Pro Pro  Val Gly Gln 
    1265                 1270                 1275             


Thr Cys  Gly Glu Phe Thr Lys  Pro Phe Phe Glu Phe  Gly Thr Gly 
    1280                 1285                 1290             


Tyr Ile  Ala Asn Pro Asp Ala  Thr Ala Asp Cys Ala  Tyr Cys Gln 
    1295                 1300                 1305             


Tyr Lys  Val Gly Asp Glu Tyr  Leu Ala Arg Ile Asn  Ala Ser Phe 
    1310                 1315                 1320             


Ser Tyr  Leu Trp Arg Asn Phe  Gly Phe Ile 
    1325                 1330             


<210>  19
<211>  870
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Ser Thr Thr Leu Ala Ala Pro Ala Lys Leu Lys Ser Leu Leu Leu 
1               5                   10                  15      


Asn Leu His Thr His Cys Ile Gly Leu His Val Asn Asp Val Thr Pro 
            20                  25                  30          


Lys Val Tyr Phe Lys Leu Leu Ile Arg His Leu Leu Gln Ile Ser Arg 
        35                  40                  45              


Ser Asn Ala Ala His Pro Lys Leu Arg Arg Arg Ala Gln Ile Leu Leu 
    50                  55                  60                  


Val Ser Leu Phe Leu Ser Gly Val Thr Leu Phe Ser Gly Val Thr Tyr 
65                  70                  75                  80  


Ser Thr Phe Lys Ile Ile Leu Lys Cys Tyr Lys Phe Tyr Lys Phe Pro 
                85                  90                  95      


Trp Lys Arg Arg Asn Arg Arg Pro Leu Ile Arg Arg Thr Arg Ser Gln 
            100                 105                 110         


Met Gln Leu Asp Ser Gly Ala Arg Ile Met Tyr Ile Pro Glu Val Glu 
        115                 120                 125             


Leu Val Asp Arg Gln Ser Pro Asp Asp Asn Lys Phe Met Asn Ala Thr 
    130                 135                 140                 


Asp Lys Lys Lys Arg Lys Arg Ile Phe Ile Pro Pro Lys Asp Asn Asp 
145                 150                 155                 160 


Val Tyr Glu His Asp Lys Phe Leu Phe Lys Asn Val Glu Leu Glu Arg 
                165                 170                 175     


Ala Lys Asn Ser Gln Leu Phe Tyr Ser Lys Phe Leu Asn Gln Met Asn 
            180                 185                 190         


Val Leu Ser Lys Ile Leu Ile Pro Thr Val Phe Asp Lys Asn Phe Leu 
        195                 200                 205             


Leu Leu Thr Ala Gln Ile Phe Phe Leu Val Met Arg Thr Trp Leu Ser 
    210                 215                 220                 


Leu Phe Val Ala Lys Leu Asp Gly Gln Ile Val Lys Asn Ile Ile Ala 
225                 230                 235                 240 


Gly Arg Gly Arg Ser Phe Leu Trp Asp Leu Gly Cys Trp Phe Leu Ile 
                245                 250                 255     


Ala Val Pro Ala Ser Tyr Thr Asn Ser Ala Ile Lys Leu Leu Gln Arg 
            260                 265                 270         


Lys Leu Ser Leu Asn Phe Arg Val Asn Leu Thr Arg Tyr Ile His Asp 
        275                 280                 285             


Met Tyr Leu Asp Lys Arg Leu Thr Phe Tyr Lys Leu Ile Phe Asp Ala 
    290                 295                 300                 


Lys Ala Ser Asn Ser Val Ile Lys Asn Ile Asp Asn Ser Ile Thr Asn 
305                 310                 315                 320 


Asp Val Ala Lys Phe Cys Asp Ala Thr Cys Ser Val Phe Ala Asn Ile 
                325                 330                 335     


Ala Lys Pro Val Ile Asp Leu Ile Phe Phe Ser Val Tyr Leu Arg Asp 
            340                 345                 350         


Asn Leu Gly Thr Val Gly Val Ala Gly Ile Phe Val Asn Tyr Phe Ile 
        355                 360                 365             


Thr Gly Phe Ile Leu Arg Lys Tyr Thr Pro Pro Leu Gly Lys Leu Ala 
    370                 375                 380                 


Gly Glu Arg Ser Ala Ser Asp Gly Asp Tyr Tyr Asn Tyr His Leu Asn 
385                 390                 395                 400 


Met Ile Asn Asn Ser Glu Glu Ile Ala Phe Tyr Gln Gly Thr Ala Val 
                405                 410                 415     


Glu Arg Thr Lys Val Lys Glu Leu Tyr Asp Val Leu Met Glu Lys Met 
            420                 425                 430         


Leu Leu Val Asp Lys Val Lys Phe Gly Tyr Asn Met Leu Glu Asp Tyr 
        435                 440                 445             


Val Leu Lys Tyr Thr Trp Ser Gly Leu Gly Tyr Val Phe Ala Ser Ile 
    450                 455                 460                 


Pro Ile Val Met Ser Thr Leu Ala Thr Gly Ile Asn Ser Glu Glu Lys 
465                 470                 475                 480 


Asn Met Lys Glu Phe Ile Val Asn Lys Arg Leu Met Leu Ser Leu Ala 
                485                 490                 495     


Asp Ala Gly Ser Arg Leu Met His Ser Ile Lys Asp Ile Ser Gln Leu 
            500                 505                 510         


Thr Gly Tyr Thr Asn Arg Ile Phe Thr Leu Leu Ser Val Leu His Arg 
        515                 520                 525             


Val His Ser Leu Asn Phe Asn Tyr Gly Ala Val Pro Ser Ile Leu Ser 
    530                 535                 540                 


Ile Arg Thr Glu Asp Ala Ser Arg Asn Ser Asn Leu Leu Pro Thr Thr 
545                 550                 555                 560 


Asp Asn Ser Gln Asp Ala Ile Arg Gly Thr Ile Gln Arg Asn Phe Asn 
                565                 570                 575     


Gly Ile Arg Leu Glu Asn Ile Asp Val Ile Ile Pro Ser Val Arg Ala 
            580                 585                 590         


Ser Glu Gly Ile Lys Leu Ile Asn Lys Leu Thr Phe Gln Ile Pro Leu 
        595                 600                 605             


His Ile Asp Pro Ile Thr Ser Lys Ser Asn Ser Ile Gln Asp Leu Ser 
    610                 615                 620                 


Lys Ala Asn Asp Ile Lys Leu Pro Phe Leu Gln Gly Ser Gly Ser Ser 
625                 630                 635                 640 


Leu Leu Ile Leu Gly Pro Asn Gly Cys Gly Lys Ser Ser Ile Gln Arg 
                645                 650                 655     


Ile Ile Ala Glu Ile Trp Pro Val Tyr Asn Lys Asn Gly Leu Leu Ser 
            660                 665                 670         


Ile Pro Ser Glu Asn Asn Ile Phe Phe Ile Pro Gln Lys Pro Tyr Phe 
        675                 680                 685             


Ser Arg Gly Gly Thr Leu Arg Asp Gln Ile Ile Tyr Pro Met Ser Ser 
    690                 695                 700                 


Asp Glu Phe Phe Asp Arg Gly Phe Arg Asp Lys Glu Leu Val Gln Ile 
705                 710                 715                 720 


Leu Val Glu Val Lys Leu Asp Tyr Leu Leu Lys Arg Gly Val Gly Leu 
                725                 730                 735     


Thr Tyr Leu Asp Ala Ile Ala Asp Trp Lys Asp Leu Leu Ser Gly Gly 
            740                 745                 750         


Glu Lys Gln Arg Val Asn Phe Ala Arg Ile Met Phe His Lys Pro Leu 
        755                 760                 765             


Tyr Val Val Leu Asp Glu Ala Thr Asn Ala Ile Ser Val Asp Met Glu 
    770                 775                 780                 


Asp Tyr Leu Phe Asn Leu Leu Lys Arg Tyr Arg Phe Asn Phe Ile Ser 
785                 790                 795                 800 


Ile Ser Gln Arg Pro Thr Leu Ile Lys Tyr His Glu Met Leu Leu Glu 
                805                 810                 815     


Ile Gly Glu Asn Arg Asp Gly Lys Trp Gln Leu Gln Ala Val Gly Thr 
            820                 825                 830         


Asp Glu Ala Ile Thr Ser Ile Asp Asn Glu Ile Glu Glu Leu Glu Arg 
        835                 840                 845             


Lys Leu Glu Arg Val Lys Gly Trp Glu Asp Glu Arg Thr Lys Leu Arg 
    850                 855                 860                 


Glu Lys Leu Glu Ile Ile 
865                 870 


<210>  20
<211>  853
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  20

Met Ile Ser Thr Ala Ser Ala Phe Tyr Gln Lys His Arg Val Asn Leu 
1               5                   10                  15      


Leu Arg Ser Ser Tyr Ile Ile Leu Leu Leu Ala Thr Leu Tyr Asn Ser 
            20                  25                  30          


Asn Ser Ser Ser Ser Asn Asn Lys Thr Asp Lys Lys Asp Ser Glu Ser 
        35                  40                  45              


Thr Val Leu Glu Asn Lys Lys Ile Glu Glu Gly Lys Glu Thr Ala Val 
    50                  55                  60                  


Asp Arg Glu Glu Asp Glu Ser Ser Lys Glu Glu Leu Thr Ile Val Ser 
65                  70                  75                  80  


Lys His Ser Thr Asp Ser Glu Asp Gly Ala Ile Ile Ile Asp Lys Glu 
                85                  90                  95      


Ser Lys Thr Asn His Lys Gly Gly Glu Arg Lys Gly Lys Val Asp Phe 
            100                 105                 110         


Leu Phe Lys Leu Leu Leu His Asp Lys Lys Cys Leu Ile Leu Phe Ile 
        115                 120                 125             


Thr Gln Ala Ile Leu Leu Asn Ile Arg Thr Leu Leu Ser Leu Arg Val 
    130                 135                 140                 


Ala Thr Leu Asp Gly Gln Leu Val Ser Thr Leu Val Arg Ala Gln Tyr 
145                 150                 155                 160 


Ala Asn Phe Thr Lys Ile Leu Leu Gly Lys Trp Met Ile Leu Gly Ile 
                165                 170                 175     


Pro Ala Ser Phe Ile Asn Ser Leu Ile Ser Tyr Thr Thr Lys Leu Cys 
            180                 185                 190         


Ala Val Thr Ile Asn Arg Lys Val Ser Asp Phe Leu Leu Ser Lys Tyr 
        195                 200                 205             


Leu Ser Asn His His Thr Phe Tyr Ser Val Ala Ser Ala Glu Ser Val 
    210                 215                 220                 


Ser Glu Ile Gln Asp Asn Leu Thr Lys Asp Ile Tyr Thr Phe Ser Met 
225                 230                 235                 240 


Asn Ser Ser Leu Leu Leu Asn Gln Leu Leu Lys Pro Met Leu Asp Leu 
                245                 250                 255     


Ile Leu Cys Ser Phe Lys Leu Leu Thr Ser Asn Thr Ser Val Met Gly 
            260                 265                 270         


Glu Gly Thr Leu Ala Leu Gly Leu Ile Val Tyr Ala Ser Asn Ser Leu 
        275                 280                 285             


Leu Lys Leu Ile Gln Pro Asn Phe Thr Arg Leu Thr Met Ala Ser Ala 
    290                 295                 300                 


Ser Leu Glu Ser Trp Phe Arg Ser Leu His Ser Asn Leu His Ser Ser 
305                 310                 315                 320 


Asn Glu Glu Ile Ala Leu Leu Arg Gly Gln Lys Arg Glu Leu Glu Asn 
                325                 330                 335     


Val Asp Tyr Ser Phe Tyr Arg Leu Val Leu Phe Leu Asn Arg Glu Ile 
            340                 345                 350         


Lys Ala Arg Ala Ile Tyr Asp Val Ala Thr Ala Phe Val Ile Lys Tyr 
        355                 360                 365             


Thr Trp Gly Ala Ala Gly Leu Val Leu Cys Ser Ile Pro Ile Phe Phe 
    370                 375                 380                 


Lys Asn Lys Pro Ser Glu Asp Thr Leu Gln Leu Lys Glu Pro Gly Asn 
385                 390                 395                 400 


Asp Met Thr Ala Asp Phe Ile Thr Asn Arg Arg Leu Leu Val Thr Ala 
                405                 410                 415     


Ser Ser Ser Ile Gly Arg Phe Val Glu Leu Lys Arg Asn Ile Gln Gln 
            420                 425                 430         


Leu Arg Gly Ile Arg Leu Arg Leu Asn Lys Phe Asn Asp Leu Leu Asp 
        435                 440                 445             


Ala Asn Lys Gly Asp Asp Glu Lys Glu Pro Arg Asp Glu Arg Cys Ile 
    450                 455                 460                 


Val Glu Tyr Asp Asp Ser Arg Ile Lys Phe Glu Asn Ile Pro Leu Ile 
465                 470                 475                 480 


Thr Pro Ala Asn Gln Val Leu Val Pro Glu Leu Ser Phe Asp Leu Lys 
                485                 490                 495     


His Gly Asn His Leu Leu Ile Ile Gly Pro Asn Gly Cys Gly Lys Ser 
            500                 505                 510         


Ser Leu Phe Arg Ile Leu Gly Gly Leu Trp Pro Ile Arg Ala Thr Pro 
        515                 520                 525             


Asn Lys Asn His Gln Ser Lys Leu Ile Met Pro Arg Arg Thr Val Asp 
    530                 535                 540                 


Arg Asp Cys Ala Ile Phe Tyr Leu Pro Gln Arg Pro Tyr Met Gly Asn 
545                 550                 555                 560 


Arg Ser Thr Phe Arg Glu Gln Ile Ile Tyr Pro Asp Ser Ile Glu Gln 
                565                 570                 575     


Phe Lys Glu Arg Tyr His Asn Asp Tyr Asp Leu Gly Asp Ala Asp Leu 
            580                 585                 590         


Ile Lys Ile Leu Gln Leu Leu Asp Leu Glu Asp Leu Val Thr Glu Asn 
        595                 600                 605             


Met Ser Leu Leu Leu Ala Gln Arg Thr Ser Lys Asn Asp Ser Gln Gln 
    610                 615                 620                 


Leu Ser Thr Glu Asp Asn Gln Ser Pro Cys Ala Ile Lys Val Arg Asp 
625                 630                 635                 640 


Ala Phe Ser Ile Val Arg Asn Trp Ser Glu Glu Leu Thr Ile Gly Val 
                645                 650                 655     


Gln Gln Arg Leu Ala Met Ala Arg Met Tyr Tyr His Lys Pro Lys Phe 
            660                 665                 670         


Ala Val Leu Asp Glu Cys Thr Ser Ala Val Ala Pro Glu Met Glu Gln 
        675                 680                 685             


Arg Met Tyr Glu Asn Ala Gln Asn Phe Gly Ile Ser Leu Ile Ser Val 
    690                 695                 700                 


Cys His Arg Thr Ser Leu Trp His Phe His Asn Tyr Leu Leu Lys Phe 
705                 710                 715                 720 


Asp Gly Lys Gly Gly Tyr Gln Phe Gly Pro Phe Asn Pro Lys Glu Arg 
                725                 730                 735     


Leu Cys Asn Glu Glu Lys Leu Leu Glu Leu Asn Ala Ile Leu Asp Gln 
            740                 745                 750         


Gln Val Pro Leu Trp Glu Arg Lys Leu Lys Asp Leu Thr Ile Ala Lys 
        755                 760                 765             


Glu Ser Asn Ile Ile Arg Lys Ser Glu Thr Asn Leu Asn Leu Phe Glu 
    770                 775                 780                 


Lys Ile Glu Asp Pro Lys Thr Ser Lys Ser Asn Ala Leu Phe Asn Ala 
785                 790                 795                 800 


Asn Lys Gly Gln Arg Ile Thr Ser Pro Thr Gly Gln Glu Thr Ser Lys 
                805                 810                 815     


Arg Leu Pro Leu Phe Ser Gln Pro Ser Ser Ser Ala Ser Ser Asn Leu 
            820                 825                 830         


Leu Arg Asn Asn Lys Ser Leu Asn Lys Lys Val Lys Thr Lys Lys Glu 
        835                 840                 845             


Glu Gly Lys Glu Arg 
    850             


<210>  21
<211>  542
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Ala Gly Ala Thr Ser Ser Ile Ile Arg Glu Asn Asp Phe Glu Asp 
1               5                   10                  15      


Glu Leu Ala Glu Ser Met Gln Ser Tyr Asn Arg Glu Thr Ala Asp Lys 
            20                  25                  30          


Leu Ala Leu Thr Arg Thr Glu Ser Val Lys Pro Glu Pro Glu Ile Thr 
        35                  40                  45              


Ala Pro Pro His Ser Arg Phe Ser Arg Ser Phe Lys Thr Val Leu Ile 
    50                  55                  60                  


Ala Gln Cys Ala Phe Thr Gly Phe Phe Ser Thr Ile Ala Gly Ala Ile 
65                  70                  75                  80  


Tyr Tyr Pro Val Leu Ser Val Ile Glu Arg Lys Phe Asp Ile Asp Glu 
                85                  90                  95      


Glu Leu Val Asn Val Thr Val Val Val Tyr Phe Val Phe Gln Gly Leu 
            100                 105                 110         


Ala Pro Thr Phe Met Gly Gly Phe Ala Asp Ser Leu Gly Arg Arg Pro 
        115                 120                 125             


Val Val Leu Val Ala Ile Val Ile Tyr Phe Gly Ala Cys Ile Gly Leu 
    130                 135                 140                 


Ala Cys Ala Gln Thr Tyr Ala Gln Ile Ile Val Leu Arg Cys Leu Gln 
145                 150                 155                 160 


Ala Ala Gly Ile Ser Pro Val Ile Ala Ile Asn Ser Gly Ile Met Gly 
                165                 170                 175     


Asp Val Thr Thr Arg Ala Glu Arg Gly Gly Tyr Val Gly Tyr Val Ala 
            180                 185                 190         


Gly Phe Gln Val Leu Gly Ser Ala Phe Gly Ala Leu Ile Gly Ala Gly 
        195                 200                 205             


Leu Ser Ser Arg Trp Gly Trp Arg Ala Ile Phe Trp Phe Leu Ala Ile 
    210                 215                 220                 


Gly Ser Gly Ile Cys Phe Leu Ala Ser Phe Leu Ile Leu Pro Glu Thr 
225                 230                 235                 240 


Lys Arg Asn Ile Ser Gly Asn Gly Ser Val Thr Pro Lys Ser Tyr Leu 
                245                 250                 255     


Asn Arg Ala Pro Ile Leu Val Leu Pro Thr Val Arg Lys Ser Leu His 
            260                 265                 270         


Leu Asp Asn Pro Asp Tyr Glu Thr Leu Glu Leu Pro Thr Gln Leu Asn 
        275                 280                 285             


Leu Leu Ala Pro Phe Lys Ile Leu Lys Ala Tyr Glu Ile Cys Ile Leu 
    290                 295                 300                 


Met Leu Val Ala Gly Leu Gln Phe Ala Met Tyr Thr Thr His Leu Thr 
305                 310                 315                 320 


Ala Leu Ser Thr Ala Leu Ser Lys Gln Tyr His Leu Thr Val Ala Lys 
                325                 330                 335     


Val Gly Leu Cys Tyr Leu Pro Ser Gly Ile Cys Thr Leu Cys Ser Ile 
            340                 345                 350         


Val Ile Ala Gly Arg Tyr Leu Asn Trp Asn Tyr Arg Arg Arg Leu Lys 
        355                 360                 365             


Tyr Tyr Gln Asn Trp Leu Gly Lys Lys Arg Ser Lys Leu Leu Glu Glu 
    370                 375                 380                 


His Asp Asn Asp Leu Asn Leu Val Gln Arg Ile Ile Glu Asn Asp Pro 
385                 390                 395                 400 


Lys Tyr Thr Phe Asn Ile Phe Lys Ala Arg Leu Gln Pro Ala Phe Val 
                405                 410                 415     


Thr Leu Leu Leu Ser Ser Ser Gly Phe Cys Ala Tyr Gly Trp Cys Ile 
            420                 425                 430         


Thr Val Lys Ala Pro Leu Ala Ala Val Leu Cys Met Ser Gly Phe Ala 
        435                 440                 445             


Ser Leu Phe Ser Asn Cys Ile Leu Thr Phe Ser Thr Thr Leu Ile Val 
    450                 455                 460                 


Asp Leu Phe Pro Thr Lys Thr Ser Thr Ala Thr Gly Cys Leu Asn Leu 
465                 470                 475                 480 


Phe Arg Cys Ile Leu Ser Ala Val Phe Ile Ala Ala Leu Ser Lys Met 
                485                 490                 495     


Val Glu Lys Met Lys Phe Gly Gly Val Phe Thr Phe Leu Gly Ala Leu 
            500                 505                 510         


Thr Ser Ser Ser Ser Ile Leu Leu Phe Ile Leu Leu Arg Lys Gly Lys 
        515                 520                 525             


Glu Leu Ala Phe Lys Arg Lys Lys Gln Glu Leu Gly Val Asn 
    530                 535                 540         


<210>  22
<211>  608
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  22

Met Ser Asp Lys Asn Ser Arg Ile Ala Ile Val Ser Ala Asp Lys Cys 
1               5                   10                  15      


Lys Pro Lys Lys Cys Arg Gln Glu Cys Lys Arg Ser Cys Pro Val Val 
            20                  25                  30          


Lys Thr Gly Lys Leu Cys Ile Glu Val Thr Pro Thr Ser Lys Ile Ala 
        35                  40                  45              


Phe Ile Ser Glu Ile Leu Cys Ile Gly Cys Gly Ile Cys Val Lys Lys 
    50                  55                  60                  


Cys Pro Phe Asp Ala Ile Gln Ile Ile Asn Leu Pro Thr Asn Leu Glu 
65                  70                  75                  80  


Ala His Val Thr His Arg Tyr Ser Ala Asn Ser Phe Lys Leu His Arg 
                85                  90                  95      


Leu Pro Thr Pro Arg Pro Gly Gln Val Leu Gly Leu Val Gly Thr Asn 
            100                 105                 110         


Gly Ile Gly Lys Ser Thr Ala Leu Lys Ile Leu Ala Gly Lys Gln Lys 
        115                 120                 125             


Pro Asn Leu Gly Arg Phe Asp Asp Pro Pro Glu Trp Gln Glu Ile Ile 
    130                 135                 140                 


Lys Tyr Phe Arg Gly Ser Glu Leu Gln Asn Tyr Phe Thr Lys Met Leu 
145                 150                 155                 160 


Glu Asp Asp Ile Lys Ala Ile Ile Lys Pro Gln Tyr Val Asp Asn Ile 
                165                 170                 175     


Pro Arg Ala Ile Lys Gly Pro Val Gln Lys Val Gly Glu Leu Leu Lys 
            180                 185                 190         


Leu Arg Met Glu Lys Ser Pro Glu Asp Val Lys Arg Tyr Ile Lys Ile 
        195                 200                 205             


Leu Gln Leu Glu Asn Val Leu Lys Arg Asp Ile Glu Lys Leu Ser Gly 
    210                 215                 220                 


Gly Glu Leu Gln Arg Phe Ala Ile Gly Met Ser Cys Val Gln Glu Ala 
225                 230                 235                 240 


Asp Val Tyr Met Phe Asp Glu Pro Ser Ser Tyr Leu Asp Val Lys Gln 
                245                 250                 255     


Arg Leu Asn Ala Ala Gln Ile Ile Arg Ser Leu Leu Ala Pro Thr Lys 
            260                 265                 270         


Tyr Val Ile Cys Val Glu His Asp Leu Ser Val Leu Asp Tyr Leu Ser 
        275                 280                 285             


Asp Phe Val Cys Ile Ile Tyr Gly Val Pro Ser Val Tyr Gly Val Val 
    290                 295                 300                 


Thr Leu Pro Ala Ser Val Arg Glu Gly Ile Asn Ile Phe Leu Asp Gly 
305                 310                 315                 320 


His Ile Pro Ala Glu Asn Leu Arg Phe Arg Thr Glu Ala Leu Gln Phe 
                325                 330                 335     


Arg Ile Ala Asp Ala Thr Glu Asp Leu Gln Asn Asp Ser Ala Ser Arg 
            340                 345                 350         


Ala Phe Ser Tyr Pro Ser Leu Lys Lys Thr Gln Gly Asp Phe Val Leu 
        355                 360                 365             


Asn Val Glu Glu Gly Glu Phe Ser Asp Ser Glu Ile Leu Val Met Met 
    370                 375                 380                 


Gly Glu Asn Gly Thr Gly Lys Thr Thr Leu Ile Lys Leu Leu Ala Gly 
385                 390                 395                 400 


Ala Leu Lys Pro Asp Glu Gly Gln Asp Ile Pro Lys Leu Asn Val Ser 
                405                 410                 415     


Met Lys Pro Gln Lys Ile Ala Pro Lys Phe Pro Gly Thr Val Arg Gln 
            420                 425                 430         


Leu Phe Phe Lys Lys Ile Arg Gly Gln Phe Leu Asn Pro Gln Phe Gln 
        435                 440                 445             


Thr Asp Val Val Lys Pro Leu Arg Ile Asp Asp Ile Ile Asp Gln Glu 
    450                 455                 460                 


Val Gln His Leu Ser Gly Gly Glu Leu Gln Arg Val Ala Ile Val Leu 
465                 470                 475                 480 


Ala Leu Gly Ile Pro Ala Asp Ile Tyr Leu Ile Asp Glu Pro Ser Ala 
                485                 490                 495     


Tyr Leu Asp Ser Glu Gln Arg Ile Ile Cys Ser Lys Val Ile Arg Arg 
            500                 505                 510         


Phe Ile Leu His Asn Lys Lys Thr Ala Phe Ile Val Glu His Asp Phe 
        515                 520                 525             


Ile Met Ala Thr Tyr Leu Ala Asp Lys Val Ile Val Phe Glu Gly Ile 
    530                 535                 540                 


Pro Ser Lys Asn Ala His Ala Arg Ala Pro Glu Ser Leu Leu Thr Gly 
545                 550                 555                 560 


Cys Asn Arg Phe Leu Lys Asn Leu Asn Val Thr Phe Arg Arg Asp Pro 
                565                 570                 575     


Asn Ser Phe Arg Pro Arg Ile Asn Lys Leu Asp Ser Gln Met Asp Lys 
            580                 585                 590         


Glu Gln Lys Ser Ser Gly Asn Tyr Phe Phe Leu Asp Asn Thr Gly Ile 
        595                 600                 605             


<210>  23
<211>  1501
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Ser Asn Ile Lys Ser Thr Gln Asp Ser Ser His Asn Ala Val Ala 
1               5                   10                  15      


Arg Ser Ser Ser Ala Ser Phe Ala Ala Ser Glu Glu Ser Phe Thr Gly 
            20                  25                  30          


Ile Thr His Asp Lys Asp Glu Gln Ser Asp Thr Pro Ala Asp Lys Leu 
        35                  40                  45              


Thr Lys Met Leu Thr Gly Pro Ala Arg Asp Thr Ala Ser Gln Ile Ser 
    50                  55                  60                  


Ala Thr Val Ser Glu Met Ala Pro Asp Val Val Ser Lys Val Glu Ser 
65                  70                  75                  80  


Phe Ala Asp Ala Leu Ser Arg His Thr Thr Arg Ser Gly Ala Phe Asn 
                85                  90                  95      


Met Asp Ser Asp Ser Asp Asp Gly Phe Asp Ala His Ala Ile Phe Glu 
            100                 105                 110         


Ser Phe Val Arg Asp Ala Asp Glu Gln Gly Ile His Ile Arg Lys Ala 
        115                 120                 125             


Gly Val Thr Ile Glu Asp Val Ser Ala Lys Gly Val Asp Ala Ser Ala 
    130                 135                 140                 


Leu Glu Gly Ala Thr Phe Gly Asn Ile Leu Cys Leu Pro Leu Thr Ile 
145                 150                 155                 160 


Phe Lys Gly Ile Lys Ala Lys Arg His Gln Lys Met Arg Gln Ile Ile 
                165                 170                 175     


Ser Asn Val Asn Ala Leu Ala Glu Ala Gly Glu Met Ile Leu Val Leu 
            180                 185                 190         


Gly Arg Pro Gly Ala Gly Cys Ser Ser Phe Leu Lys Val Thr Ala Gly 
        195                 200                 205             


Glu Ile Asp Gln Phe Ala Gly Gly Val Ser Gly Glu Val Ala Tyr Asp 
    210                 215                 220                 


Gly Ile Pro Gln Glu Glu Met Met Lys Arg Tyr Lys Ala Asp Val Ile 
225                 230                 235                 240 


Tyr Asn Gly Glu Leu Asp Val His Phe Pro Tyr Leu Thr Val Lys Gln 
                245                 250                 255     


Thr Leu Asp Phe Ala Ile Ala Cys Lys Thr Pro Ala Leu Arg Val Asn 
            260                 265                 270         


Asn Val Ser Lys Lys Glu Tyr Ile Ala Ser Arg Arg Asp Leu Tyr Ala 
        275                 280                 285             


Thr Ile Phe Gly Leu Arg His Thr Tyr Asn Thr Lys Val Gly Asn Asp 
    290                 295                 300                 


Phe Val Arg Gly Val Ser Gly Gly Glu Arg Lys Arg Val Ser Ile Ala 
305                 310                 315                 320 


Glu Ala Leu Ala Ala Lys Gly Ser Ile Tyr Cys Trp Asp Asn Ala Thr 
                325                 330                 335     


Arg Gly Leu Asp Ala Ser Thr Ala Leu Glu Tyr Ala Lys Ala Ile Arg 
            340                 345                 350         


Ile Met Thr Asn Leu Leu Lys Ser Thr Ala Phe Val Thr Ile Tyr Gln 
        355                 360                 365             


Ala Ser Glu Asn Ile Tyr Glu Thr Phe Asp Lys Val Thr Val Leu Tyr 
    370                 375                 380                 


Ser Gly Lys Gln Ile Tyr Phe Gly Leu Ile His Glu Ala Lys Pro Tyr 
385                 390                 395                 400 


Phe Ala Lys Met Gly Tyr Leu Cys Pro Pro Arg Gln Ala Thr Ala Glu 
                405                 410                 415     


Phe Leu Thr Ala Leu Thr Asp Pro Asn Gly Phe His Leu Ile Lys Pro 
            420                 425                 430         


Gly Tyr Glu Asn Lys Val Pro Arg Thr Ala Glu Glu Phe Glu Thr Tyr 
        435                 440                 445             


Trp Leu Asn Ser Pro Glu Phe Ala Gln Met Lys Lys Asp Ile Ala Ala 
    450                 455                 460                 


Tyr Lys Glu Lys Val Asn Thr Glu Lys Thr Lys Glu Val Tyr Asp Glu 
465                 470                 475                 480 


Ser Met Ala Gln Glu Lys Ser Lys Tyr Thr Arg Lys Lys Ser Tyr Tyr 
                485                 490                 495     


Thr Val Ser Tyr Trp Glu Gln Val Lys Leu Cys Thr Gln Arg Gly Phe 
            500                 505                 510         


Gln Arg Ile Tyr Gly Asn Lys Ser Tyr Thr Val Ile Asn Val Cys Ser 
        515                 520                 525             


Ala Ile Ile Gln Ser Phe Ile Thr Gly Ser Leu Phe Tyr Asn Thr Pro 
    530                 535                 540                 


Ser Ser Thr Ser Gly Ala Phe Ser Arg Gly Gly Val Leu Tyr Phe Ala 
545                 550                 555                 560 


Leu Leu Tyr Tyr Ser Leu Met Gly Leu Ala Asn Ile Ser Phe Glu His 
                565                 570                 575     


Arg Pro Ile Leu Gln Lys His Lys Gly Tyr Ser Leu Tyr His Pro Ser 
            580                 585                 590         


Ala Glu Ala Ile Gly Ser Thr Leu Ala Ser Phe Pro Phe Arg Met Ile 
        595                 600                 605             


Gly Leu Thr Cys Phe Phe Ile Ile Leu Phe Phe Leu Ser Gly Leu His 
    610                 615                 620                 


Arg Thr Ala Gly Ser Phe Phe Thr Ile Tyr Leu Phe Leu Thr Met Cys 
625                 630                 635                 640 


Ser Glu Ala Ile Asn Gly Leu Phe Glu Met Val Ser Ser Val Cys Asp 
                645                 650                 655     


Thr Leu Ser Gln Ala Asn Ser Ile Ser Gly Ile Leu Met Met Ser Ile 
            660                 665                 670         


Ser Met Tyr Ser Thr Tyr Met Ile Gln Leu Pro Ser Met His Pro Trp 
        675                 680                 685             


Phe Lys Trp Ile Ser Tyr Val Leu Pro Ile Arg Tyr Ala Phe Glu Ser 
    690                 695                 700                 


Met Leu Asn Ala Glu Phe His Gly Arg His Met Asp Cys Ala Asn Thr 
705                 710                 715                 720 


Leu Val Pro Ser Gly Gly Asp Tyr Asp Asn Leu Ser Asp Asp Tyr Lys 
                725                 730                 735     


Val Cys Ala Phe Val Gly Ser Lys Pro Gly Gln Ser Tyr Val Leu Gly 
            740                 745                 750         


Asp Asp Tyr Leu Lys Asn Gln Phe Gln Tyr Val Tyr Lys His Thr Trp 
        755                 760                 765             


Arg Asn Phe Gly Ile Leu Trp Cys Phe Leu Leu Gly Tyr Val Val Leu 
    770                 775                 780                 


Lys Val Ile Phe Thr Glu Tyr Lys Arg Pro Val Lys Gly Gly Gly Asp 
785                 790                 795                 800 


Ala Leu Ile Phe Lys Lys Gly Ser Lys Arg Phe Ile Ala His Ala Asp 
                805                 810                 815     


Glu Glu Ser Pro Asp Asn Val Asn Asp Ile Asp Ala Lys Glu Gln Phe 
            820                 825                 830         


Ser Ser Glu Ser Ser Gly Ala Asn Asp Glu Val Phe Asp Asp Leu Glu 
        835                 840                 845             


Ala Lys Gly Val Phe Ile Trp Lys Asp Val Cys Phe Thr Ile Pro Tyr 
    850                 855                 860                 


Glu Gly Gly Lys Arg Met Leu Leu Asp Asn Val Ser Gly Tyr Cys Ile 
865                 870                 875                 880 


Pro Gly Thr Met Thr Ala Leu Met Gly Glu Ser Gly Ala Gly Lys Thr 
                885                 890                 895     


Thr Leu Leu Asn Thr Leu Ala Gln Arg Asn Val Gly Ile Ile Thr Gly 
            900                 905                 910         


Asp Met Leu Val Asn Gly Arg Pro Ile Asp Ala Ser Phe Glu Arg Arg 
        915                 920                 925             


Thr Gly Tyr Val Gln Gln Gln Asp Ile His Ile Ala Glu Leu Thr Val 
    930                 935                 940                 


Arg Glu Ser Leu Gln Phe Ser Ala Arg Met Arg Arg Pro Gln His Leu 
945                 950                 955                 960 


Pro Asp Ser Glu Lys Met Asp Tyr Val Glu Lys Ile Ile Arg Val Leu 
                965                 970                 975     


Gly Met Glu Glu Tyr Ala Glu Ala Leu Val Gly Glu Val Gly Cys Gly 
            980                 985                 990         


Leu Asn Val Glu Gln Arg Lys Lys  Leu Ser Ile Gly Val  Glu Leu Val 
        995                 1000                 1005             


Ala Lys  Pro Asp Leu Leu Leu  Phe Leu Asp Glu Pro  Thr Ser Gly 
    1010                 1015                 1020             


Leu Asp  Ser Gln Ser Ser Trp  Ala Ile Ile Gln Leu  Leu Arg Lys 
    1025                 1030                 1035             


Leu Ser  Lys Ala Gly Gln Ser  Ile Leu Cys Thr Ile  His Gln Pro 
    1040                 1045                 1050             


Ser Ala  Thr Leu Phe Glu Glu  Phe Asp Arg Leu Leu  Leu Leu Arg 
    1055                 1060                 1065             


Lys Gly  Gly Gln Thr Val Tyr  Phe Gly Asp Ile Gly  Lys Asn Ser 
    1070                 1075                 1080             


Ala Thr  Ile Leu Asn Tyr Phe  Glu Arg Asn Gly Ala  Arg Lys Cys 
    1085                 1090                 1095             


Asp Ser  Ser Glu Asn Pro Ala  Glu Tyr Ile Leu Glu  Ala Ile Gly 
    1100                 1105                 1110             


Ala Gly  Ala Thr Ala Ser Val  Lys Glu Asp Trp His  Glu Lys Trp 
    1115                 1120                 1125             


Leu Asn  Ser Val Glu Phe Glu  Gln Thr Lys Glu Lys  Val Gln Asp 
    1130                 1135                 1140             


Leu Ile  Asn Asp Leu Ser Lys  Gln Glu Thr Lys Ser  Glu Val Gly 
    1145                 1150                 1155             


Asp Lys  Pro Ser Lys Tyr Ala  Thr Ser Tyr Ala Tyr  Gln Phe Arg 
    1160                 1165                 1170             


Tyr Val  Leu Ile Arg Thr Ser  Thr Ser Phe Trp Arg  Ser Leu Asn 
    1175                 1180                 1185             


Tyr Ile  Met Ser Lys Met Met  Leu Met Leu Val Gly  Gly Leu Tyr 
    1190                 1195                 1200             


Ile Gly  Phe Thr Phe Phe Asn  Val Gly Lys Ser Tyr  Val Gly Leu 
    1205                 1210                 1215             


Gln Asn  Ala Met Phe Ala Ala  Phe Ile Ser Ile Ile  Leu Ser Ala 
    1220                 1225                 1230             


Pro Ala  Met Asn Gln Ile Gln  Gly Arg Ala Ile Ala  Ser Arg Glu 
    1235                 1240                 1245             


Leu Phe  Glu Val Arg Glu Ser  Gln Ser Asn Met Phe  His Trp Ser 
    1250                 1255                 1260             


Leu Val  Leu Ile Thr Gln Tyr  Leu Ser Glu Leu Pro  Tyr His Leu 
    1265                 1270                 1275             


Phe Phe  Ser Thr Ile Phe Phe  Val Ser Ser Tyr Phe  Pro Leu Arg 
    1280                 1285                 1290             


Ile Phe  Phe Glu Ala Ser Arg  Ser Ala Val Tyr Phe  Leu Asn Tyr 
    1295                 1300                 1305             


Cys Ile  Met Phe Gln Leu Tyr  Tyr Val Gly Leu Gly  Leu Met Ile 
    1310                 1315                 1320             


Leu Tyr  Met Ser Pro Asn Leu  Pro Ser Ala Asn Val  Ile Leu Gly 
    1325                 1330                 1335             


Leu Cys  Leu Ser Phe Met Leu  Ser Phe Cys Gly Val  Thr Gln Pro 
    1340                 1345                 1350             


Val Ser  Leu Met Pro Gly Phe  Trp Thr Phe Met Trp  Lys Ala Ser 
    1355                 1360                 1365             


Pro Tyr  Thr Tyr Phe Val Gln  Asn Leu Val Gly Ile  Met Leu His 
    1370                 1375                 1380             


Lys Lys  Pro Val Val Cys Lys  Lys Lys Glu Leu Asn  Tyr Phe Asn 
    1385                 1390                 1395             


Pro Pro  Asn Gly Ser Thr Cys  Gly Glu Tyr Met Lys  Pro Phe Leu 
    1400                 1405                 1410             


Glu Lys  Ala Thr Gly Tyr Ile  Glu Asn Pro Asp Ala  Thr Ser Asp 
    1415                 1420                 1425             


Cys Ala  Tyr Cys Ile Tyr Glu  Val Gly Asp Asn Tyr  Leu Thr His 
    1430                 1435                 1440             


Ile Ser  Ser Lys Tyr Ser Tyr  Leu Trp Arg Asn Phe  Gly Ile Phe 
    1445                 1450                 1455             


Trp Ile  Tyr Ile Phe Phe Asn  Ile Ile Ala Met Val  Cys Val Tyr 
    1460                 1465                 1470             


Tyr Leu  Phe His Val Arg Gln  Ser Ser Phe Leu Ser  Pro Val Ser 
    1475                 1480                 1485             


Ile Leu  Asn Lys Ile Lys Asn  Ile Arg Lys Lys Lys  Gln 
    1490                 1495                 1500     


<210>  24
<211>  1290
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Met Asn Phe Leu Ser Phe Lys Thr Thr Lys His Tyr His Ile Phe Arg 
1               5                   10                  15      


Tyr Val Asn Ile Arg Asn Asp Tyr Arg Leu Leu Met Ile Met Ile Ile 
            20                  25                  30          


Gly Thr Val Ala Thr Gly Leu Val Pro Ala Ile Thr Ser Ile Leu Thr 
        35                  40                  45              


Gly Arg Val Phe Asp Leu Leu Ser Val Phe Val Ala Asn Gly Ser His 
    50                  55                  60                  


Gln Gly Leu Tyr Ser Gln Leu Val Gln Arg Ser Met Ala Val Met Ala 
65                  70                  75                  80  


Leu Gly Ala Ala Ser Val Pro Val Met Trp Leu Ser Leu Thr Ser Trp 
                85                  90                  95      


Met His Ile Gly Glu Arg Gln Gly Phe Arg Ile Arg Ser Gln Ile Leu 
            100                 105                 110         


Glu Ala Tyr Leu Glu Glu Lys Pro Met Glu Trp Tyr Asp Asn Asn Glu 
        115                 120                 125             


Lys Leu Leu Gly Asp Phe Thr Gln Ile Asn Arg Cys Val Glu Glu Leu 
    130                 135                 140                 


Arg Ser Ser Ser Ala Glu Ala Ser Ala Ile Thr Phe Gln Asn Leu Val 
145                 150                 155                 160 


Ala Ile Cys Ala Leu Leu Gly Thr Ser Phe Tyr Tyr Ser Trp Ser Leu 
                165                 170                 175     


Thr Leu Ile Ile Leu Cys Ser Ser Pro Ile Ile Thr Phe Phe Ala Val 
            180                 185                 190         


Val Phe Ser Arg Met Ile His Val Tyr Ser Glu Lys Glu Asn Ser Glu 
        195                 200                 205             


Thr Ser Lys Ala Ala Gln Leu Leu Thr Trp Ser Met Asn Ala Ala Gln 
    210                 215                 220                 


Leu Val Arg Leu Tyr Cys Thr Gln Arg Leu Glu Arg Lys Lys Phe Lys 
225                 230                 235                 240 


Glu Ile Ile Leu Asn Cys Asn Thr Phe Phe Ile Lys Ser Cys Phe Phe 
                245                 250                 255     


Val Ala Ala Asn Ala Gly Ile Leu Arg Phe Leu Thr Leu Thr Met Phe 
            260                 265                 270         


Val Gln Gly Phe Trp Phe Gly Ser Ala Met Ile Lys Lys Gly Lys Leu 
        275                 280                 285             


Asn Ile Asn Asp Val Ile Thr Cys Phe His Ser Cys Ile Met Leu Gly 
    290                 295                 300                 


Ser Thr Leu Asn Asn Thr Leu His Gln Ile Val Val Leu Gln Lys Gly 
305                 310                 315                 320 


Gly Val Ala Met Glu Lys Ile Met Thr Leu Leu Lys Asp Gly Ser Lys 
                325                 330                 335     


Arg Asn Pro Leu Asn Lys Thr Val Ala His Gln Phe Pro Leu Asp Tyr 
            340                 345                 350         


Ala Thr Ser Asp Leu Thr Phe Ala Asn Val Ser Phe Ser Tyr Pro Ser 
        355                 360                 365             


Arg Pro Ser Glu Ala Val Leu Lys Asn Val Ser Leu Asn Phe Ser Ala 
    370                 375                 380                 


Gly Gln Phe Thr Phe Ile Val Gly Lys Ser Gly Ser Gly Lys Ser Thr 
385                 390                 395                 400 


Leu Ser Asn Leu Leu Leu Arg Phe Tyr Asp Gly Tyr Asn Gly Ser Ile 
                405                 410                 415     


Ser Ile Asn Gly His Asn Ile Gln Thr Ile Asp Gln Lys Leu Leu Ile 
            420                 425                 430         


Glu Asn Ile Thr Val Val Glu Gln Arg Cys Thr Leu Phe Asn Asp Thr 
        435                 440                 445             


Leu Arg Lys Asn Ile Leu Leu Gly Ser Thr Asp Ser Val Arg Asn Ala 
    450                 455                 460                 


Asp Cys Ser Thr Asn Glu Asn Arg His Leu Ile Lys Asp Ala Cys Gln 
465                 470                 475                 480 


Met Ala Leu Leu Asp Arg Phe Ile Leu Asp Leu Pro Asp Gly Leu Glu 
                485                 490                 495     


Thr Leu Ile Gly Thr Gly Gly Val Thr Leu Ser Gly Gly Gln Gln Gln 
            500                 505                 510         


Arg Val Ala Ile Ala Arg Ala Phe Ile Arg Asp Thr Pro Ile Leu Phe 
        515                 520                 525             


Leu Asp Glu Ala Val Ser Ala Leu Asp Ile Val His Arg Asn Leu Leu 
    530                 535                 540                 


Met Lys Ala Ile Arg His Trp Arg Lys Gly Lys Thr Thr Ile Ile Leu 
545                 550                 555                 560 


Thr His Glu Leu Ser Gln Ile Glu Ser Asp Asp Tyr Leu Tyr Leu Met 
                565                 570                 575     


Lys Glu Gly Glu Val Val Glu Ser Gly Thr Gln Ser Glu Leu Leu Ala 
            580                 585                 590         


Asp Pro Thr Thr Thr Phe Ser Thr Trp Tyr His Leu Gln Asn Asp Tyr 
        595                 600                 605             


Ser Asp Ala Lys Thr Ile Val Asp Thr Glu Thr Glu Glu Lys Ser Ile 
    610                 615                 620                 


His Thr Val Glu Ser Phe Asn Ser Gln Leu Glu Thr Pro Lys Leu Gly 
625                 630                 635                 640 


Ser Cys Leu Ser Asn Leu Gly Tyr Asp Glu Thr Asp Gln Leu Ser Phe 
                645                 650                 655     


Tyr Glu Ala Ile Tyr Gln Lys Arg Ser Asn Val Arg Thr Arg Arg Val 
            660                 665                 670         


Lys Val Glu Glu Glu Asn Ile Gly Tyr Ala Leu Lys Gln Gln Lys Asn 
        675                 680                 685             


Thr Glu Ser Ser Thr Gly Pro Gln Leu Leu Ser Ile Ile Gln Ile Ile 
    690                 695                 700                 


Lys Arg Met Ile Lys Ser Ile Arg Tyr Lys Lys Ile Leu Ile Leu Gly 
705                 710                 715                 720 


Leu Leu Cys Ser Leu Ile Ala Gly Ala Thr Asn Pro Val Phe Ser Tyr 
                725                 730                 735     


Thr Phe Ser Phe Leu Leu Glu Gly Ile Val Pro Ser Thr Asp Gly Lys 
            740                 745                 750         


Thr Gly Ser Ser His Tyr Leu Ala Lys Trp Ser Leu Leu Val Leu Gly 
        755                 760                 765             


Val Ala Ala Ala Asp Gly Ile Phe Asn Phe Ala Lys Gly Phe Leu Leu 
    770                 775                 780                 


Asp Cys Cys Ser Glu Tyr Trp Val Met Asp Leu Arg Asn Glu Val Met 
785                 790                 795                 800 


Glu Lys Leu Thr Arg Lys Asn Met Asp Trp Phe Ser Gly Glu Asn Asn 
                805                 810                 815     


Lys Ala Ser Glu Ile Ser Ala Leu Val Leu Asn Asp Leu Arg Asp Leu 
            820                 825                 830         


Arg Ser Leu Val Ser Glu Phe Leu Ser Ala Met Thr Ser Phe Val Thr 
        835                 840                 845             


Val Ser Thr Ile Gly Leu Ile Trp Ala Leu Val Ser Gly Trp Lys Leu 
    850                 855                 860                 


Ser Leu Val Cys Ile Ser Met Phe Pro Leu Ile Ile Ile Phe Ser Ala 
865                 870                 875                 880 


Ile Tyr Gly Gly Ile Leu Gln Lys Cys Glu Thr Asp Tyr Lys Thr Ser 
                885                 890                 895     


Val Ala Gln Leu Glu Asn Cys Leu Tyr Gln Ile Val Thr Asn Ile Lys 
            900                 905                 910         


Thr Ile Lys Cys Leu Gln Ala Glu Phe His Phe Gln Leu Thr Tyr His 
        915                 920                 925             


Asp Leu Lys Ile Lys Met Gln Gln Ile Ala Ser Lys Arg Ala Ile Ala 
    930                 935                 940                 


Thr Gly Phe Gly Ile Ser Met Thr Asn Met Ile Val Met Cys Ile Gln 
945                 950                 955                 960 


Ala Ile Ile Tyr Tyr Tyr Gly Leu Lys Leu Val Met Ile His Glu Tyr 
                965                 970                 975     


Thr Ser Lys Glu Met Phe Thr Thr Phe Thr Leu Leu Leu Phe Thr Ile 
            980                 985                 990         


Met Ser Cys Thr Ser Leu Val Ser  Gln Ile Pro Asp Ile  Ser Arg Gly 
        995                 1000                 1005             


Gln Arg  Ala Ala Ser Trp Ile  Tyr Arg Ile Leu Asp  Glu Lys His 
    1010                 1015                 1020             


Asn Thr  Leu Glu Val Glu Asn  Asn Asn Ala Arg Thr  Val Gly Ile 
    1025                 1030                 1035             


Ala Gly  His Thr Tyr His Gly  Lys Glu Lys Lys Pro  Ile Val Ser 
    1040                 1045                 1050             


Ile Gln  Asn Leu Thr Phe Ala  Tyr Pro Ser Ala Pro  Thr Ala Phe 
    1055                 1060                 1065             


Val Tyr  Lys Asn Met Asn Phe  Asp Met Phe Cys Gly  Gln Thr Leu 
    1070                 1075                 1080             


Gly Ile  Ile Gly Glu Ser Gly  Thr Gly Lys Ser Thr  Leu Val Leu 
    1085                 1090                 1095             


Leu Leu  Thr Lys Leu Tyr Asn  Cys Glu Val Gly Lys  Ile Lys Ile 
    1100                 1105                 1110             


Asp Gly  Thr Asp Val Asn Asp  Trp Asn Leu Thr Ser  Leu Arg Lys 
    1115                 1120                 1125             


Glu Ile  Ser Val Val Glu Gln  Lys Pro Leu Leu Phe  Asn Gly Thr 
    1130                 1135                 1140             


Ile Arg  Asp Asn Leu Thr Tyr  Gly Leu Gln Asp Glu  Ile Leu Glu 
    1145                 1150                 1155             


Ile Glu  Met Tyr Asp Ala Leu  Lys Tyr Val Gly Ile  His Asp Phe 
    1160                 1165                 1170             


Val Ile  Ser Ser Pro Gln Gly  Leu Asp Thr Arg Ile  Asp Thr Thr 
    1175                 1180                 1185             


Leu Leu  Ser Gly Gly Gln Ala  Gln Arg Leu Cys Ile  Ala Arg Ala 
    1190                 1195                 1200             


Leu Leu  Arg Lys Ser Lys Ile  Leu Ile Leu Asp Glu  Cys Thr Ser 
    1205                 1210                 1215             


Ala Leu  Asp Ser Val Ser Ser  Ser Ile Ile Asn Glu  Ile Val Lys 
    1220                 1225                 1230             


Lys Gly  Pro Pro Ala Leu Leu  Thr Met Val Ile Thr  His Ser Glu 
    1235                 1240                 1245             


Gln Met  Met Arg Ser Cys Asn  Ser Ile Ala Val Leu  Lys Asp Gly 
    1250                 1255                 1260             


Lys Val  Val Glu Arg Gly Asn  Phe Asp Thr Leu Tyr  Asn Asn Arg 
    1265                 1270                 1275             


Gly Glu  Leu Phe Gln Ile Val  Ser Asn Gln Ser Ser  
    1280                 1285                 1290 


<210>  25
<211>  1592
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Gly Thr Asp Pro Leu Ile Ile Arg Asn Asn Gly Ser Phe Trp Glu 
1               5                   10                  15      


Val Asp Asp Phe Thr Arg Leu Gly Arg Thr Gln Leu Leu Ser Tyr Tyr 
            20                  25                  30          


Leu Pro Leu Ala Ile Ile Ala Ser Ile Gly Ile Phe Ala Leu Cys Arg 
        35                  40                  45              


Ser Gly Leu Ser Arg Tyr Val Arg Ser Ala Glu Cys Asp Leu Val Asn 
    50                  55                  60                  


Glu Tyr Leu Phe Gly Ala Gln Glu Glu Arg Lys Glu Asp Asn Ser Ile 
65                  70                  75                  80  


Glu Arg Leu Leu Arg Asn Ser Asn Thr Gln Ala Asn Tyr Val Asn Val 
                85                  90                  95      


Lys Lys Gln Gly Arg Ile Leu Lys Leu Arg His Phe Asp Ile Thr Thr 
            100                 105                 110         


Ile Asp Val Lys Gln Ile Asp Ala Lys Asn His Gly Gly Leu Thr Phe 
        115                 120                 125             


Ser Arg Pro Ser Thr Ser Asp His Leu Arg Lys Ser Ser Glu Ile Val 
    130                 135                 140                 


Leu Met Ser Leu Gln Ile Ile Gly Leu Ser Phe Leu Arg Val Thr Lys 
145                 150                 155                 160 


Ile Asn Ile Glu Leu Thr Asn Arg Asp Val Thr Thr Leu Leu Leu Phe 
                165                 170                 175     


Trp Leu Ile Leu Leu Ser Leu Ser Ile Leu Arg Val Tyr Lys Arg Ser 
            180                 185                 190         


Thr Asn Leu Trp Ala Ile Cys Phe Thr Ala His Thr Thr Ile Trp Ile 
        195                 200                 205             


Ser Thr Trp Ile Pro Ile Arg Ser Val Tyr Ile Gly Asn Ile Asp Asp 
    210                 215                 220                 


Val Pro Ser Gln Ile Phe Tyr Ile Phe Glu Phe Val Ile Thr Ser Thr 
225                 230                 235                 240 


Leu Gln Pro Ile Lys Leu Thr Ser Pro Ile Lys Asp Asn Ser Ser Ile 
                245                 250                 255     


Ile Tyr Val Arg Asp Asp His Thr Ser Pro Ser Arg Glu His Ile Ser 
            260                 265                 270         


Ser Ile Leu Ser Cys Ile Thr Trp Ser Trp Ile Thr Asn Phe Ile Trp 
        275                 280                 285             


Glu Ala Gln Lys Asn Thr Ile Lys Leu Lys Asp Ile Trp Gly Leu Ser 
    290                 295                 300                 


Met Glu Asp Tyr Ser Ile Phe Ile Leu Lys Gly Phe Thr Arg Arg Asn 
305                 310                 315                 320 


Lys His Ile Asn Asn Leu Thr Leu Ala Leu Phe Glu Ser Phe Lys Thr 
                325                 330                 335     


Tyr Leu Leu Ile Gly Met Leu Trp Val Leu Val Asn Ser Ile Val Asn 
            340                 345                 350         


Leu Leu Pro Thr Ile Leu Met Lys Arg Phe Leu Glu Ile Val Asp Asn 
        355                 360                 365             


Pro Asn Arg Ser Ser Ser Cys Met Asn Leu Ala Trp Leu Tyr Ile Ile 
    370                 375                 380                 


Gly Met Phe Ile Cys Arg Leu Thr Leu Ala Ile Cys Asn Ser Gln Gly 
385                 390                 395                 400 


Gln Phe Val Ser Asp Lys Ile Cys Leu Arg Ile Arg Ala Ile Leu Ile 
                405                 410                 415     


Gly Glu Ile Tyr Ala Lys Gly Leu Arg Arg Arg Leu Phe Thr Ser Pro 
            420                 425                 430         


Lys Thr Ser Ser Asp Ser Asp Ser Ile Ser Ala Asn Leu Gly Thr Ile 
        435                 440                 445             


Ile Asn Leu Ile Ser Ile Asp Ser Phe Lys Val Ser Glu Leu Ala Asn 
    450                 455                 460                 


Tyr Leu Tyr Val Thr Val Gln Ala Val Ile Met Ile Ile Val Val Val 
465                 470                 475                 480 


Gly Leu Leu Phe Asn Phe Leu Gly Val Ser Ala Phe Ala Gly Ile Ser 
                485                 490                 495     


Ile Ile Leu Val Met Phe Pro Leu Asn Phe Leu Leu Ala Asn Leu Leu 
            500                 505                 510         


Gly Lys Phe Gln Lys Gln Thr Leu Lys Cys Thr Asp Gln Arg Ile Ser 
        515                 520                 525             


Lys Leu Asn Glu Cys Leu Gln Asn Ile Arg Ile Val Lys Tyr Phe Ala 
    530                 535                 540                 


Trp Glu Arg Asn Ile Ile Asn Glu Ile Lys Ser Ile Arg Gln Lys Glu 
545                 550                 555                 560 


Leu Arg Ser Leu Leu Lys Lys Ser Leu Val Trp Ser Val Thr Ser Phe 
                565                 570                 575     


Leu Trp Phe Val Thr Pro Thr Leu Val Thr Gly Val Thr Phe Ala Ile 
            580                 585                 590         


Cys Thr Phe Val Gln His Glu Asp Leu Asn Ala Pro Leu Ala Phe Thr 
        595                 600                 605             


Thr Leu Ser Leu Phe Thr Leu Leu Lys Thr Pro Leu Asp Gln Leu Ser 
    610                 615                 620                 


Asn Met Leu Ser Phe Ile Asn Gln Ser Lys Val Ser Leu Lys Arg Ile 
625                 630                 635                 640 


Ser Asp Phe Leu Arg Met Asp Asp Thr Glu Lys Tyr Asn Gln Leu Thr 
                645                 650                 655     


Ile Ser Pro Asp Lys Asn Lys Ile Glu Phe Lys Asn Ala Thr Leu Thr 
            660                 665                 670         


Trp Asn Glu Asn Asp Ser Asp Met Asn Ala Phe Lys Leu Cys Gly Leu 
        675                 680                 685             


Asn Ile Lys Phe Gln Ile Gly Lys Leu Asn Leu Ile Leu Gly Ser Thr 
    690                 695                 700                 


Gly Ser Gly Lys Ser Ala Leu Leu Leu Gly Leu Leu Gly Glu Leu Asn 
705                 710                 715                 720 


Leu Ile Ser Gly Ser Ile Ile Val Pro Ser Leu Glu Pro Lys His Asp 
                725                 730                 735     


Leu Ile Pro Asp Cys Glu Gly Leu Thr Asn Ser Phe Ala Tyr Cys Ser 
            740                 745                 750         


Gln Ser Ala Trp Leu Leu Asn Asp Thr Val Lys Asn Asn Ile Ile Phe 
        755                 760                 765             


Asp Asn Phe Tyr Asn Glu Asp Arg Tyr Asn Lys Val Ile Asp Ala Cys 
    770                 775                 780                 


Gly Leu Lys Arg Asp Leu Glu Ile Leu Pro Ala Gly Asp Leu Thr Glu 
785                 790                 795                 800 


Ile Gly Glu Lys Gly Ile Thr Leu Ser Gly Gly Gln Lys Gln Arg Ile 
                805                 810                 815     


Ser Leu Ala Arg Ala Val Tyr Ser Ser Ala Lys His Val Leu Leu Asp 
            820                 825                 830         


Asp Cys Leu Ser Ala Val Asp Ser His Thr Ala Val Trp Ile Tyr Glu 
        835                 840                 845             


Asn Cys Ile Thr Gly Pro Leu Met Lys Asn Arg Thr Cys Ile Leu Val 
    850                 855                 860                 


Thr His Asn Val Ser Leu Thr Leu Arg Asn Ala His Phe Ala Ile Val 
865                 870                 875                 880 


Leu Glu Asn Gly Lys Val Lys Asn Gln Gly Thr Ile Thr Glu Leu Gln 
                885                 890                 895     


Ser Lys Gly Leu Phe Lys Glu Lys Tyr Val Gln Leu Ser Ser Arg Asp 
            900                 905                 910         


Ser Ile Asn Glu Lys Asn Ala Asn Arg Leu Lys Ala Pro Arg Lys Asn 
        915                 920                 925             


Asp Ser Gln Lys Ile Glu Pro Val Thr Glu Asn Ile Asn Phe Asp Ala 
    930                 935                 940                 


Asn Phe Val Asn Asp Gly Gln Leu Ile Glu Glu Glu Glu Lys Ser Asn 
945                 950                 955                 960 


Gly Ala Ile Ser Pro Asp Val Tyr Lys Trp Tyr Leu Lys Phe Phe Gly 
                965                 970                 975     


Gly Phe Lys Ala Leu Thr Ala Leu Phe Ala Leu Tyr Ile Thr Ala Gln 
            980                 985                 990         


Ile Leu Phe Ile Ser Gln Ser Trp  Trp Ile Arg His Trp  Val Asn Asp 
        995                 1000                 1005             


Thr Asn  Val Arg Ile Asn Ala  Pro Gly Phe Ala Met  Asp Thr Leu 
    1010                 1015                 1020             


Pro Leu  Lys Gly Met Thr Asp  Ser Ser Lys Asn Lys  His Asn Ala 
    1025                 1030                 1035             


Phe Tyr  Tyr Leu Thr Val Tyr  Phe Leu Ile Gly Ile  Ile Gln Ala 
    1040                 1045                 1050             


Met Leu  Gly Gly Phe Lys Thr  Met Met Thr Phe Leu  Ser Gly Met 
    1055                 1060                 1065             


Arg Ala  Ser Arg Lys Ile Phe  Asn Asn Leu Leu Asp  Leu Val Leu 
    1070                 1075                 1080             


His Ala  Gln Ile Arg Phe Phe  Asp Val Thr Pro Val  Gly Arg Ile 
    1085                 1090                 1095             


Met Asn  Arg Phe Ser Lys Asp  Ile Glu Gly Val Asp  Gln Glu Leu 
    1100                 1105                 1110             


Ile Pro  Tyr Leu Glu Val Thr  Ile Phe Cys Leu Ile  Gln Cys Ala 
    1115                 1120                 1125             


Ser Ile  Ile Phe Leu Ile Thr  Val Ile Thr Pro Arg  Phe Leu Thr 
    1130                 1135                 1140             


Val Ala  Val Ile Val Phe Val  Leu Tyr Phe Phe Val  Gly Lys Trp 
    1145                 1150                 1155             


Tyr Leu  Thr Ala Ser Arg Glu  Leu Lys Arg Leu Asp  Ser Ile Thr 
    1160                 1165                 1170             


Lys Ser  Pro Ile Phe Gln His  Phe Ser Glu Thr Leu  Val Gly Val 
    1175                 1180                 1185             


Cys Thr  Ile Arg Ala Phe Gly  Asp Glu Arg Arg Phe  Ile Leu Glu 
    1190                 1195                 1200             


Asn Met  Asn Lys Ile Asp Gln  Asn Asn Arg Ala Phe  Phe Tyr Leu 
    1205                 1210                 1215             


Ser Val  Thr Val Lys Trp Phe  Ser Phe Arg Val Asp  Met Ile Gly 
    1220                 1225                 1230             


Ala Phe  Ile Val Leu Ala Ser  Gly Ser Phe Ile Leu  Leu Asn Ile 
    1235                 1240                 1245             


Ala Asn  Ile Asp Ser Gly Leu  Ala Gly Ile Ser Leu  Thr Tyr Ala 
    1250                 1255                 1260             


Ile Leu  Phe Thr Asp Gly Ala  Leu Trp Leu Val Arg  Leu Tyr Ser 
    1265                 1270                 1275             


Thr Phe  Glu Met Asn Met Asn  Ser Val Glu Arg Leu  Lys Glu Tyr 
    1280                 1285                 1290             


Ser Ser  Ile Glu Gln Glu Asn  Tyr Leu Gly His Asp  Glu Gly Arg 
    1295                 1300                 1305             


Ile Leu  Leu Leu Asn Glu Pro  Ser Trp Pro Lys Asp  Gly Glu Ile 
    1310                 1315                 1320             


Glu Ile  Glu Asn Leu Ser Leu  Arg Tyr Ala Pro Asn  Leu Pro Pro 
    1325                 1330                 1335             


Val Ile  Arg Asn Val Ser Phe  Lys Val Asp Pro Gln  Ser Lys Ile 
    1340                 1345                 1350             


Gly Ile  Val Gly Arg Thr Gly  Ala Gly Lys Ser Thr  Ile Ile Thr 
    1355                 1360                 1365             


Ala Leu  Phe Arg Leu Leu Glu  Pro Ile Thr Gly Cys  Ile Lys Ile 
    1370                 1375                 1380             


Asp Gly  Gln Asp Ile Ser Lys  Ile Asp Leu Val Thr  Leu Arg Arg 
    1385                 1390                 1395             


Ser Ile  Thr Ile Ile Pro Gln  Asp Pro Ile Leu Phe  Ala Gly Thr 
    1400                 1405                 1410             


Ile Lys  Ser Asn Val Asp Pro  Tyr Asp Glu Tyr Asp  Glu Lys Lys 
    1415                 1420                 1425             


Ile Phe  Lys Ala Leu Ser Gln  Val Asn Leu Ile Ser  Ser His Glu 
    1430                 1435                 1440             


Phe Glu  Glu Val Leu Asn Ser  Glu Glu Arg Phe Asn  Ser Thr His 
    1445                 1450                 1455             


Asn Lys  Phe Leu Asn Leu His  Thr Glu Ile Ala Glu  Gly Gly Leu 
    1460                 1465                 1470             


Asn Leu  Ser Gln Gly Glu Arg  Gln Leu Leu Phe Ile  Ala Arg Ser 
    1475                 1480                 1485             


Leu Leu  Arg Glu Pro Lys Ile  Ile Leu Leu Asp Glu  Ala Thr Ser 
    1490                 1495                 1500             


Ser Ile  Asp Tyr Asp Ser Asp  His Leu Ile Gln Gly  Ile Ile Arg 
    1505                 1510                 1515             


Ser Glu  Phe Asn Lys Ser Thr  Ile Leu Thr Ile Ala  His Arg Leu 
    1520                 1525                 1530             


Arg Ser  Val Ile Asp Tyr Asp  Arg Ile Ile Val Met  Asp Ala Gly 
    1535                 1540                 1545             


Glu Val  Lys Glu Tyr Asp Arg  Pro Ser Glu Leu Leu  Lys Asp Glu 
    1550                 1555                 1560             


Arg Gly  Ile Phe Tyr Ser Met  Cys Arg Asp Ser Gly  Gly Leu Glu 
    1565                 1570                 1575             


Leu Leu  Lys Gln Ile Ala Lys  Gln Ser Ser Lys Met  Met Lys 
    1580                 1585                 1590         


<210>  26
<211>  1661
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Met His His Val Leu Asn Ser Thr Arg Pro Asp His Arg Phe Trp Phe 
1               5                   10                  15      


Tyr Asp Asp Val Thr Gln Tyr Gly Arg Thr Lys Tyr Leu Asn Tyr Tyr 
            20                  25                  30          


Thr Pro Leu Val Leu Leu Ile Phe Thr Val Leu Phe Ile Thr Tyr Asn 
        35                  40                  45              


Ile Trp Lys His Tyr Tyr Tyr Tyr Asp Val Leu His Leu Lys Gln Lys 
    50                  55                  60                  


Asn Pro Ile Asp Glu Leu Leu Tyr Ser Ser Thr Asp Glu Asp Glu Gln 
65                  70                  75                  80  


Ser Pro Leu Ile Asn Asn Asn Thr Ile Thr Thr Asn Tyr Val Asp Asn 
                85                  90                  95      


Asn Cys Thr Lys Asp Ala Leu Lys Asn Arg His Phe Ser Leu Glu Lys 
            100                 105                 110         


Leu Lys Ser Val Lys Val Asn Gly Glu Pro His Gly Thr Pro Glu Ile 
        115                 120                 125             


Val Arg Arg Gly Phe Ile Glu Lys Ser Arg Ile Ile Leu Glu Phe Phe 
    130                 135                 140                 


Leu Val Leu Ser Gln Val Ile Ile His Ser Phe Ile Leu Leu His Tyr 
145                 150                 155                 160 


Val Asn Lys Asn Pro Glu Phe Thr Gln Gln Gly Thr Ile Thr Gly Leu 
                165                 170                 175     


Val Glu Trp Cys Ala Leu Phe Ile Ile Val Ser Leu Arg Leu Ala Asn 
            180                 185                 190         


Val Asn Gln Asn Phe Lys Phe Ile Asn Lys Tyr Pro Gly Asn Leu Trp 
        195                 200                 205             


Ser Val Ser Phe Ile Asn Tyr Leu Ala Leu Phe Ile Ser Met Ile Leu 
    210                 215                 220                 


Pro Phe Arg Ser Ile Phe Ile His His Ile Asn Ser Pro Ile Ser Arg 
225                 230                 235                 240 


Lys Tyr Tyr Ile Ser Gln Ile Ser Ile Asn Leu Ala Leu Phe Leu Leu 
                245                 250                 255     


Leu Phe Phe Ala Arg Ile Arg Asn Asn Phe Ala Ile Ile Tyr Lys Thr 
            260                 265                 270         


Asp Ser Trp Ile Thr Pro Ser Pro Glu Pro Val Thr Ser Ile Ala Gly 
        275                 280                 285             


Phe Ile Cys Trp Ala Trp Leu Asp Ser Phe Val Trp Lys Ala His Lys 
    290                 295                 300                 


Val Ser Ile Lys Val Lys Asp Ile Trp Gly Leu Met Met Gln Asp Tyr 
305                 310                 315                 320 


Ser Phe Phe Val Val Lys Lys Phe Arg Tyr Phe Val Asp His Lys Val 
                325                 330                 335     


Lys Arg Lys Arg Ile Phe Ser Leu Asn Leu Phe Phe Phe Phe Ser Asn 
            340                 345                 350         


Tyr Leu Val Leu Gln Cys Phe Trp Ala Phe Leu Gly Ser Val Leu Ser 
        355                 360                 365             


Phe Ile Pro Thr Val Leu Leu Lys Arg Ile Leu Glu Tyr Val Glu Asp 
    370                 375                 380                 


Gln Ser Ser Ala Pro Ser Asn Leu Ala Trp Phe Tyr Val Thr Val Met 
385                 390                 395                 400 


Phe Val Gly Arg Ile Leu Val Ala Ile Cys Gln Ala Gln Ala Leu Phe 
                405                 410                 415     


Phe Gly Arg Arg Val Cys Ile Arg Met Lys Ser Ile Ile Ile Ser Glu 
            420                 425                 430         


Ile Tyr Thr Lys Ala Leu Arg Arg Lys Ile Ser Thr Asn Lys Thr Lys 
        435                 440                 445             


Pro Ser Asn Glu Asp Pro Gln Glu Ile Asn Asp Gln Lys Ser Ile Asn 
    450                 455                 460                 


Gly Asp Glu Glu Ser Thr Ser Ser Ala Asn Leu Gly Ala Ile Ile Asn 
465                 470                 475                 480 


Leu Met Ala Ile Asp Ala Phe Lys Val Ser Glu Ile Cys Gly Tyr Leu 
                485                 490                 495     


His Ser Phe Leu Glu Ala Phe Val Met Thr Val Val Ala Leu Ala Leu 
            500                 505                 510         


Leu Tyr Arg Leu Leu Gly Phe Ala Ala Ile Val Gly Val Leu Ile Ile 
        515                 520                 525             


Val Ala Met Leu Pro Leu Asn Tyr Lys Leu Ala Lys Tyr Ile Gly Asp 
    530                 535                 540                 


Leu Gln Lys Lys Asn Leu Ala Val Thr Asp Asn Arg Ile Gln Lys Leu 
545                 550                 555                 560 


Asn Glu Ala Phe Gln Ala Ile Arg Ile Ile Lys Tyr Phe Ser Trp Glu 
                565                 570                 575     


Glu Asn Phe Glu Lys Asp Ile Asn Thr Ile Arg Glu Asn Glu Leu Ser 
            580                 585                 590         


Leu Leu Leu Met Arg Ser Ile Val Trp Ser Ile Ser Ser Phe Leu Trp 
        595                 600                 605             


Phe Val Thr Pro Thr Ile Val Thr Ala Ala Ser Phe Ala Tyr Tyr Ile 
    610                 615                 620                 


Tyr Val Gln Gly Glu Val Leu Thr Thr Pro Val Ala Phe Thr Ala Leu 
625                 630                 635                 640 


Ser Leu Phe Thr Leu Leu Arg Asp Pro Leu Asp Arg Leu Ser Asp Met 
                645                 650                 655     


Leu Ser Phe Val Val Gln Ser Lys Val Ser Leu Asp Arg Val Gln Asp 
            660                 665                 670         


Phe Leu Asn Glu Asn Asp Thr Lys Lys Tyr Asp Gln Leu Thr Ile Asp 
        675                 680                 685             


Pro Asn Gly Asn Arg Phe Ala Phe Glu Asn Ser Thr Ile Ser Trp Asp 
    690                 695                 700                 


Lys Asp Asn Gln Asp Phe Lys Leu Lys Asp Leu Asn Ile Glu Phe Lys 
705                 710                 715                 720 


Thr Gly Lys Leu Asn Val Val Ile Gly Pro Thr Gly Ser Gly Lys Thr 
                725                 730                 735     


Ser Leu Leu Met Ala Leu Leu Gly Glu Met Tyr Leu Leu Asn Gly Lys 
            740                 745                 750         


Val Val Val Pro Ala Leu Glu Pro Arg Gln Glu Leu Ile Val Asp Ala 
        755                 760                 765             


Asn Gly Thr Thr Asn Ser Ile Ala Tyr Cys Ser Gln Ala Ala Trp Leu 
    770                 775                 780                 


Leu Asn Asp Thr Val Lys Asn Asn Ile Leu Phe Asn Ser Pro Phe Asn 
785                 790                 795                 800 


Glu Ala Arg Tyr Lys Ala Val Val Glu Ala Cys Gly Leu Lys Arg Asp 
                805                 810                 815     


Phe Glu Ile Leu Lys Ala Gly Asp Leu Thr Glu Ile Gly Glu Lys Gly 
            820                 825                 830         


Ile Thr Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Arg Ala 
        835                 840                 845             


Leu Tyr Ser Asn Ala Arg His Val Leu Leu Asp Asp Cys Leu Ser Ala 
    850                 855                 860                 


Val Asp Ser His Thr Ala Ser Trp Ile Tyr Asp Asn Cys Ile Thr Gly 
865                 870                 875                 880 


Pro Leu Met Glu Asp Arg Thr Cys Ile Leu Val Ser His Asn Ile Ala 
                885                 890                 895     


Leu Thr Leu Arg Asn Ala Glu Leu Val Val Leu Leu Glu Asp Gly Arg 
            900                 905                 910         


Val Lys Asp Gln Gly Asp Pro Ile Asp Met Leu Gln Lys Gly Leu Phe 
        915                 920                 925             


Gly Glu Asp Glu Leu Val Lys Ser Ser Ile Leu Ser Arg Ala Asn Ser 
    930                 935                 940                 


Ser Ala Asn Leu Ala Ala Lys Ser Ser Thr Ser Leu Ser Asn Leu Pro 
945                 950                 955                 960 


Ala Val Lys Glu Gln Gln Val Ser Val Asn Asn Asn Ser Ser His Phe 
                965                 970                 975     


Glu Ala Lys Lys Leu Gln Lys Ser Leu Arg Thr Glu Ala Glu Arg Thr 
            980                 985                 990         


Glu Asp Gly Lys Leu Ile Lys Glu  Glu Thr Lys Glu Glu  Gly Val Val 
        995                 1000                 1005             


Gly Leu  Asp Val Tyr Lys Trp  Tyr Leu Lys Ile Phe  Gly Gly Trp 
    1010                 1015                 1020             


Lys Ile  Val Ser Phe Leu Ala  Ser Leu Phe Leu Ile  Ala Gln Leu 
    1025                 1030                 1035             


Leu Tyr  Ile Gly Gln Ser Trp  Trp Val Arg Ala Trp  Ala Ser His 
    1040                 1045                 1050             


Asn Val  Ile Ala Lys Ile Ile  Pro Arg Ala Gln Arg  Ala Ile Ala 
    1055                 1060                 1065             


Phe Ile  Ser Lys Lys Ala Ser  His Leu Ile Asp Trp  Arg Gly Ser 
    1070                 1075                 1080             


Ser Gln  Ile Ser Met Ala Ser  Ala Glu Asn Gln Pro  Ser Ser Gly 
    1085                 1090                 1095             


His Ser  Thr Met Tyr Tyr Leu  Val Leu Tyr Leu Ile  Ile Gly Phe 
    1100                 1105                 1110             


Ala Gln  Ala Leu Leu Gly Ala  Gly Lys Thr Ile Leu  Asn Phe Val 
    1115                 1120                 1125             


Ala Gly  Ile Asn Ala Ser Arg  Lys Ile Phe Asn Met  Ile Leu Asn 
    1130                 1135                 1140             


Lys Val  Leu His Ser Lys Ile  Arg Phe Phe Asp Ala  Thr Pro Thr 
    1145                 1150                 1155             


Gly Arg  Ile Met Asn Arg Phe  Ser Lys Asp Ile Glu  Ala Ile Asp 
    1160                 1165                 1170             


Gln Glu  Leu Thr Pro Tyr Ile  Gln Gly Ala Phe Tyr  Ser Leu Ile 
    1175                 1180                 1185             


Glu Cys  Leu Ser Thr Val Ile  Leu Ile Thr Phe Ile  Thr Pro Gln 
    1190                 1195                 1200             


Phe Leu  Ser Val Ala Ile Val  Val Ser Ile Leu Tyr  Tyr Phe Val 
    1205                 1210                 1215             


Gly Tyr  Phe Tyr Met Ala Gly  Ser Arg Glu Leu Lys  Arg Phe Glu 
    1220                 1225                 1230             


Ser Ile  Ser Arg Ser Pro Ile  Tyr Gln His Phe Ser  Glu Thr Leu 
    1235                 1240                 1245             


Val Gly  Val Thr Thr Ile Arg  Ala Phe Gly Asp Glu  Gly Arg Phe 
    1250                 1255                 1260             


Met Gln  Glu Asn Leu His Lys  Ile Asp Glu Asn Asn  Lys Pro Phe 
    1265                 1270                 1275             


Phe Tyr  Leu Trp Val Ala Asn  Arg Trp Leu Ala Phe  Arg Ile Asp 
    1280                 1285                 1290             


Met Ile  Gly Ser Leu Val Ile  Phe Gly Ala Gly Leu  Phe Ile Leu 
    1295                 1300                 1305             


Phe Asn  Ile Asn Asn Leu Asp  Ser Gly Met Ala Gly  Ile Ser Leu 
    1310                 1315                 1320             


Thr Tyr  Ala Ile Ser Phe Thr  Glu Gly Ala Leu Trp  Leu Val Arg 
    1325                 1330                 1335             


Leu Tyr  Ser Glu Val Glu Met  Asn Met Asn Ser Val  Glu Arg Val 
    1340                 1345                 1350             


Lys Glu  Tyr Met Glu Ile Glu  Gln Glu Pro Tyr Asn  Glu His Lys 
    1355                 1360                 1365             


Glu Ile  Pro Pro Pro Gln Trp  Pro Gln Asp Gly Lys  Ile Glu Val 
    1370                 1375                 1380             


Asn Asp  Leu Ser Leu Arg Tyr  Ala Pro Asn Leu Pro  Arg Val Ile 
    1385                 1390                 1395             


Lys Asn  Val Ser Phe Ser Val  Asp Ala Gln Ser Lys  Ile Gly Ile 
    1400                 1405                 1410             


Val Gly  Arg Thr Gly Ala Gly  Lys Ser Thr Ile Ile  Thr Ala Leu 
    1415                 1420                 1425             


Phe Arg  Phe Leu Glu Pro Glu  Thr Gly His Ile Lys  Ile Asp Asn 
    1430                 1435                 1440             


Ile Asp  Ile Ser Gly Val Asp  Leu Gln Arg Leu Arg  Arg Ser Ile 
    1445                 1450                 1455             


Thr Ile  Ile Pro Gln Asp Pro  Thr Leu Phe Ser Gly  Thr Ile Lys 
    1460                 1465                 1470             


Thr Asn  Leu Asp Pro Tyr Asp  Glu Phe Ser Asp Arg  Gln Ile Phe 
    1475                 1480                 1485             


Glu Ala  Leu Lys Arg Val Asn  Leu Ile Ser Glu Glu  Gln Leu Gln 
    1490                 1495                 1500             


Gln Gly  Ala Thr Arg Glu Thr  Ser Asn Glu Ala Ser  Ser Thr Asn 
    1505                 1510                 1515             


Ser Glu  Asn Val Asn Lys Phe  Leu Asp Leu Ser Ser  Glu Ile Ser 
    1520                 1525                 1530             


Glu Gly  Gly Ser Asn Leu Ser  Gln Gly Gln Arg Gln  Leu Met Cys 
    1535                 1540                 1545             


Leu Ala  Arg Ser Leu Leu Arg  Ser Pro Lys Ile Ile  Leu Leu Asp 
    1550                 1555                 1560             


Glu Ala  Thr Ala Ser Ile Asp  Tyr Ser Ser Asp Ala  Lys Ile Gln 
    1565                 1570                 1575             


Glu Thr  Ile Arg Lys Glu Phe  Gln Gly Ser Thr Ile  Leu Thr Ile 
    1580                 1585                 1590             


Ala His  Arg Leu Arg Ser Val  Ile Asp Tyr Asp Lys  Ile Leu Val 
    1595                 1600                 1605             


Met Asp  Ala Gly Glu Val Lys  Glu Tyr Asp His Pro  Tyr Ser Leu 
    1610                 1615                 1620             


Leu Leu  Asn Lys Gln Ser Ala  Phe Tyr Ser Met Cys  Glu His Ser 
    1625                 1630                 1635             


Gly Glu  Leu Asp Ile Leu Ile  Glu Leu Ala Lys Lys  Ala Phe Val 
    1640                 1645                 1650             


Glu Lys  Leu Asn Ser Lys Lys  Asp 
    1655                 1660     


<210>  27
<211>  1515
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  27

Met Ala Gly Asn Leu Val Ser Trp Ala Cys Lys Leu Cys Arg Ser Pro 
1               5                   10                  15      


Glu Gly Phe Gly Pro Ile Ser Phe Tyr Gly Asp Phe Thr Gln Cys Phe 
            20                  25                  30          


Ile Asp Gly Val Ile Leu Asn Leu Ser Ala Ile Phe Met Ile Thr Phe 
        35                  40                  45              


Gly Ile Arg Asp Leu Val Asn Leu Cys Lys Lys Lys His Ser Gly Ile 
    50                  55                  60                  


Lys Tyr Arg Arg Asn Trp Ile Ile Val Ser Arg Met Ala Leu Val Leu 
65                  70                  75                  80  


Leu Glu Ile Ala Phe Val Ser Leu Ala Ser Leu Asn Ile Ser Lys Glu 
                85                  90                  95      


Glu Ala Glu Asn Phe Thr Ile Val Ser Gln Tyr Ala Ser Thr Met Leu 
            100                 105                 110         


Ser Leu Phe Val Ala Leu Ala Leu His Trp Ile Glu Tyr Asp Arg Ser 
        115                 120                 125             


Val Val Ala Asn Thr Val Leu Leu Phe Tyr Trp Leu Phe Glu Thr Phe 
    130                 135                 140                 


Gly Asn Phe Ala Lys Leu Ile Asn Ile Leu Ile Arg His Thr Tyr Glu 
145                 150                 155                 160 


Gly Ile Trp Tyr Ser Gly Gln Thr Gly Phe Ile Leu Thr Leu Phe Gln 
                165                 170                 175     


Val Ile Thr Cys Ala Ser Ile Leu Leu Leu Glu Ala Leu Pro Lys Lys 
            180                 185                 190         


Pro Leu Met Pro His Gln His Ile His Gln Thr Leu Thr Arg Arg Lys 
        195                 200                 205             


Pro Asn Pro Tyr Asp Ser Ala Asn Ile Phe Ser Arg Ile Thr Phe Ser 
    210                 215                 220                 


Trp Met Ser Gly Leu Met Lys Thr Gly Tyr Glu Lys Tyr Leu Val Glu 
225                 230                 235                 240 


Ala Asp Leu Tyr Lys Leu Pro Arg Asn Phe Ser Ser Glu Glu Leu Ser 
                245                 250                 255     


Gln Lys Leu Glu Lys Asn Trp Glu Asn Glu Leu Lys Gln Lys Ser Asn 
            260                 265                 270         


Pro Ser Leu Ser Trp Ala Ile Cys Arg Thr Phe Gly Ser Lys Met Leu 
        275                 280                 285             


Leu Ala Ala Phe Phe Lys Ala Ile His Asp Val Leu Ala Phe Thr Gln 
    290                 295                 300                 


Pro Gln Leu Leu Arg Ile Leu Ile Lys Phe Val Thr Asp Tyr Asn Ser 
305                 310                 315                 320 


Glu Arg Gln Asp Asp His Ser Ser Leu Gln Gly Phe Glu Asn Asn His 
                325                 330                 335     


Pro Gln Lys Leu Pro Ile Val Arg Gly Phe Leu Ile Ala Phe Ala Met 
            340                 345                 350         


Phe Leu Val Gly Phe Thr Gln Thr Ser Val Leu His Gln Tyr Phe Leu 
        355                 360                 365             


Asn Val Phe Asn Thr Gly Met Tyr Ile Lys Ser Ala Leu Thr Ala Leu 
    370                 375                 380                 


Ile Tyr Gln Lys Ser Leu Val Leu Ser Asn Glu Ala Ser Gly Leu Ser 
385                 390                 395                 400 


Ser Thr Gly Asp Ile Val Asn Leu Met Ser Val Asp Val Gln Lys Leu 
                405                 410                 415     


Gln Asp Leu Thr Gln Trp Leu Asn Leu Ile Trp Ser Gly Pro Phe Gln 
            420                 425                 430         


Ile Ile Ile Cys Leu Tyr Ser Leu Tyr Lys Leu Leu Gly Asn Ser Met 
        435                 440                 445             


Trp Val Gly Val Ile Ile Leu Val Ile Met Met Pro Leu Asn Ser Phe 
    450                 455                 460                 


Leu Met Arg Ile Gln Lys Lys Leu Gln Lys Ser Gln Met Lys Tyr Lys 
465                 470                 475                 480 


Asp Glu Arg Thr Arg Val Ile Ser Glu Ile Leu Asn Asn Ile Lys Ser 
                485                 490                 495     


Leu Lys Leu Tyr Ala Trp Glu Lys Pro Tyr Arg Glu Lys Leu Glu Glu 
            500                 505                 510         


Val Arg Asn Asn Lys Glu Leu Lys Asn Leu Thr Lys Leu Gly Cys Tyr 
        515                 520                 525             


Met Ala Val Thr Ser Phe Gln Phe Asn Ile Val Pro Phe Leu Val Ser 
    530                 535                 540                 


Cys Cys Thr Phe Ala Val Phe Val Tyr Thr Glu Asp Arg Ala Leu Thr 
545                 550                 555                 560 


Thr Asp Leu Val Phe Pro Ala Leu Thr Leu Phe Asn Leu Leu Ser Phe 
                565                 570                 575     


Pro Leu Met Ile Ile Pro Met Val Leu Asn Ser Phe Ile Glu Ala Ser 
            580                 585                 590         


Val Ser Ile Gly Arg Leu Phe Thr Phe Phe Thr Asn Glu Glu Leu Gln 
        595                 600                 605             


Pro Asp Ser Val Gln Arg Leu Pro Lys Val Lys Asn Ile Gly Asp Val 
    610                 615                 620                 


Ala Ile Asn Ile Gly Asp Asp Ala Thr Phe Leu Trp Gln Arg Lys Pro 
625                 630                 635                 640 


Glu Tyr Lys Val Ala Leu Lys Asn Ile Asn Phe Gln Ala Lys Lys Gly 
                645                 650                 655     


Asn Leu Thr Cys Ile Val Gly Lys Val Gly Ser Gly Lys Thr Ala Leu 
            660                 665                 670         


Leu Ser Cys Met Leu Gly Asp Leu Phe Arg Val Lys Gly Phe Ala Thr 
        675                 680                 685             


Val His Gly Ser Val Ala Tyr Val Ser Gln Val Pro Trp Ile Met Asn 
    690                 695                 700                 


Gly Thr Val Lys Glu Asn Ile Leu Phe Gly His Arg Tyr Asp Ala Glu 
705                 710                 715                 720 


Phe Tyr Glu Lys Thr Ile Lys Ala Cys Ala Leu Thr Ile Asp Leu Ala 
                725                 730                 735     


Ile Leu Met Asp Gly Asp Lys Thr Leu Val Gly Glu Lys Gly Ile Ser 
            740                 745                 750         


Leu Ser Gly Gly Gln Lys Ala Arg Leu Ser Leu Ala Arg Ala Val Tyr 
        755                 760                 765             


Ala Arg Ala Asp Thr Tyr Leu Leu Asp Asp Pro Leu Ala Ala Val Asp 
    770                 775                 780                 


Glu His Val Ala Arg His Leu Ile Glu His Val Leu Gly Pro Asn Gly 
785                 790                 795                 800 


Leu Leu His Thr Lys Thr Lys Val Leu Ala Thr Asn Lys Val Ser Ala 
                805                 810                 815     


Leu Ser Ile Ala Asp Ser Ile Ala Leu Leu Asp Asn Gly Glu Ile Thr 
            820                 825                 830         


Gln Gln Gly Thr Tyr Asp Glu Ile Thr Lys Asp Ala Asp Ser Pro Leu 
        835                 840                 845             


Trp Lys Leu Leu Asn Asn Tyr Gly Lys Lys Asn Asn Gly Lys Ser Asn 
    850                 855                 860                 


Glu Phe Gly Asp Ser Ser Glu Ser Ser Val Arg Glu Ser Ser Ile Pro 
865                 870                 875                 880 


Val Glu Gly Glu Leu Glu Gln Leu Gln Lys Leu Asn Asp Leu Asp Phe 
                885                 890                 895     


Gly Asn Ser Asp Ala Ile Ser Leu Arg Arg Ala Ser Asp Ala Thr Leu 
            900                 905                 910         


Gly Ser Ile Asp Phe Gly Asp Asp Glu Asn Ile Ala Lys Arg Glu His 
        915                 920                 925             


Arg Glu Gln Gly Lys Val Lys Trp Asn Ile Tyr Leu Glu Tyr Ala Lys 
    930                 935                 940                 


Ala Cys Asn Pro Lys Ser Val Cys Val Phe Ile Leu Phe Ile Val Ile 
945                 950                 955                 960 


Ser Met Phe Leu Ser Val Met Gly Asn Val Trp Leu Lys His Trp Ser 
                965                 970                 975     


Glu Val Asn Ser Arg Tyr Gly Ser Asn Pro Asn Ala Ala Arg Tyr Leu 
            980                 985                 990         


Ala Ile Tyr Phe Ala Leu Gly Ile  Gly Ser Ala Leu Ala  Thr Leu Ile 
        995                 1000                 1005             


Gln Thr  Ile Val Leu Trp Val  Phe Cys Thr Ile His  Ala Ser Lys 
    1010                 1015                 1020             


Tyr Leu  His Asn Leu Met Thr  Asn Ser Val Leu Arg  Ala Pro Met 
    1025                 1030                 1035             


Thr Phe  Phe Glu Thr Thr Pro  Ile Gly Arg Ile Leu  Asn Arg Phe 
    1040                 1045                 1050             


Ser Asn  Asp Ile Tyr Lys Val  Asp Ala Leu Leu Gly  Arg Thr Phe 
    1055                 1060                 1065             


Ser Gln  Phe Phe Val Asn Ala  Val Lys Val Thr Phe  Thr Ile Thr 
    1070                 1075                 1080             


Val Ile  Cys Ala Thr Thr Trp  Gln Phe Ile Phe Ile  Ile Ile Pro 
    1085                 1090                 1095             


Leu Ser  Val Phe Tyr Ile Tyr  Tyr Gln Gln Tyr Tyr  Leu Arg Thr 
    1100                 1105                 1110             


Ser Arg  Glu Leu Arg Arg Leu  Asp Ser Ile Thr Arg  Ser Pro Ile 
    1115                 1120                 1125             


Tyr Ser  His Phe Gln Glu Thr  Leu Gly Gly Leu Ala  Thr Val Arg 
    1130                 1135                 1140             


Gly Tyr  Ser Gln Gln Lys Arg  Phe Ser His Ile Asn  Gln Cys Arg 
    1145                 1150                 1155             


Ile Asp  Asn Asn Met Ser Ala  Phe Tyr Pro Ser Ile  Asn Ala Asn 
    1160                 1165                 1170             


Arg Trp  Leu Ala Tyr Arg Leu  Glu Leu Ile Gly Ser  Ile Ile Ile 
    1175                 1180                 1185             


Leu Gly  Ala Ala Thr Leu Ser  Val Phe Arg Leu Lys  Gln Gly Thr 
    1190                 1195                 1200             


Leu Thr  Ala Gly Met Val Gly  Leu Ser Leu Ser Tyr  Ala Leu Gln 
    1205                 1210                 1215             


Ile Thr  Gln Thr Leu Asn Trp  Ile Val Arg Met Thr  Val Glu Val 
    1220                 1225                 1230             


Glu Thr  Asn Ile Val Ser Val  Glu Arg Ile Lys Glu  Tyr Ala Asp 
    1235                 1240                 1245             


Leu Lys  Ser Glu Ala Pro Leu  Ile Val Glu Gly His  Arg Pro Pro 
    1250                 1255                 1260             


Lys Glu  Trp Pro Ser Gln Gly  Asp Ile Lys Phe Asn  Asn Tyr Ser 
    1265                 1270                 1275             


Thr Arg  Tyr Arg Pro Glu Leu  Asp Leu Val Leu Lys  His Ile Asn 
    1280                 1285                 1290             


Ile His  Ile Lys Pro Asn Glu  Lys Val Gly Ile Val  Gly Arg Thr 
    1295                 1300                 1305             


Gly Ala  Gly Lys Ser Ser Leu  Thr Leu Ala Leu Phe  Arg Met Ile 
    1310                 1315                 1320             


Glu Ala  Ser Glu Gly Asn Ile  Val Ile Asp Asn Ile  Ala Ile Asn 
    1325                 1330                 1335             


Glu Ile  Gly Leu Tyr Asp Leu  Arg His Lys Leu Ser  Ile Ile Pro 
    1340                 1345                 1350             


Gln Asp  Ser Gln Val Phe Glu  Gly Thr Val Arg Glu  Asn Ile Asp 
    1355                 1360                 1365             


Pro Ile  Asn Gln Tyr Thr Asp  Glu Ala Ile Trp Arg  Ala Leu Glu 
    1370                 1375                 1380             


Leu Ser  His Leu Lys Glu His  Val Leu Ser Met Ser  Asn Asp Gly 
    1385                 1390                 1395             


Leu Asp  Ala Gln Leu Thr Glu  Gly Gly Gly Asn Leu  Ser Val Gly 
    1400                 1405                 1410             


Gln Arg  Gln Leu Leu Cys Leu  Ala Arg Ala Met Leu  Val Pro Ser 
    1415                 1420                 1425             


Lys Ile  Leu Val Leu Asp Glu  Ala Thr Ala Ala Val  Asp Val Glu 
    1430                 1435                 1440             


Thr Asp  Lys Val Val Gln Glu  Thr Ile Arg Thr Ala  Phe Lys Asp 
    1445                 1450                 1455             


Arg Thr  Ile Leu Thr Ile Ala  His Arg Leu Asn Thr  Ile Met Asp 
    1460                 1465                 1470             


Ser Asp  Arg Ile Ile Val Leu  Asp Asn Gly Lys Val  Ala Glu Phe 
    1475                 1480                 1485             


Asp Ser  Pro Gly Gln Leu Leu  Ser Asp Asn Lys Ser  Leu Phe Tyr 
    1490                 1495                 1500             


Ser Leu  Cys Met Glu Ala Gly  Leu Val Asn Glu Asn  
    1505                 1510                 1515 


<210>  28
<211>  1477
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  28

Met Thr Ile Thr Val Gly Asp Ala Val Ser Glu Thr Glu Leu Glu Asn 
1               5                   10                  15      


Lys Ser Gln Asn Val Val Leu Ser Pro Lys Ala Ser Ala Ser Ser Asp 
            20                  25                  30          


Ile Ser Thr Asp Val Asp Lys Asp Thr Ser Ser Ser Trp Asp Asp Lys 
        35                  40                  45              


Ser Leu Leu Pro Thr Gly Glu Tyr Ile Val Asp Arg Asn Lys Pro Gln 
    50                  55                  60                  


Thr Tyr Leu Asn Ser Asp Asp Ile Glu Lys Val Thr Glu Ser Asp Ile 
65                  70                  75                  80  


Phe Pro Gln Lys Arg Leu Phe Ser Phe Leu His Ser Lys Lys Ile Pro 
                85                  90                  95      


Glu Val Pro Gln Thr Asp Asp Glu Arg Lys Ile Tyr Pro Leu Phe His 
            100                 105                 110         


Thr Asn Ile Ile Ser Asn Met Phe Phe Trp Trp Val Leu Pro Ile Leu 
        115                 120                 125             


Arg Val Gly Tyr Lys Arg Thr Ile Gln Pro Asn Asp Leu Phe Lys Met 
    130                 135                 140                 


Asp Pro Arg Met Ser Ile Glu Thr Leu Tyr Asp Asp Phe Glu Lys Asn 
145                 150                 155                 160 


Met Ile Tyr Tyr Phe Glu Lys Thr Arg Lys Lys Tyr Arg Lys Arg His 
                165                 170                 175     


Pro Glu Ala Thr Glu Glu Glu Val Met Glu Asn Ala Lys Leu Pro Lys 
            180                 185                 190         


His Thr Val Leu Arg Ala Leu Leu Phe Thr Phe Lys Lys Gln Tyr Phe 
        195                 200                 205             


Met Ser Ile Val Phe Ala Ile Leu Ala Asn Cys Thr Ser Gly Phe Asn 
    210                 215                 220                 


Pro Met Ile Thr Lys Arg Leu Ile Glu Phe Val Glu Glu Lys Ala Ile 
225                 230                 235                 240 


Phe His Ser Met His Val Asn Lys Gly Ile Gly Tyr Ala Ile Gly Ala 
                245                 250                 255     


Cys Leu Met Met Phe Val Asn Gly Leu Thr Phe Asn His Phe Phe His 
            260                 265                 270         


Thr Ser Gln Leu Thr Gly Val Gln Ala Lys Ser Ile Leu Thr Lys Ala 
        275                 280                 285             


Ala Met Lys Lys Met Phe Asn Ala Ser Asn Tyr Ala Arg His Cys Phe 
    290                 295                 300                 


Pro Asn Gly Lys Val Thr Ser Phe Val Thr Thr Asp Leu Ala Arg Ile 
305                 310                 315                 320 


Glu Phe Ala Leu Ser Phe Gln Pro Phe Leu Ala Gly Phe Pro Ala Ile 
                325                 330                 335     


Leu Ala Ile Cys Ile Val Leu Leu Ile Val Asn Leu Gly Pro Ile Ala 
            340                 345                 350         


Leu Val Gly Ile Gly Ile Phe Phe Gly Gly Phe Phe Ile Ser Leu Phe 
        355                 360                 365             


Ala Phe Lys Leu Ile Leu Gly Phe Arg Ile Ala Ala Asn Ile Phe Thr 
    370                 375                 380                 


Asp Ala Arg Val Thr Met Met Arg Glu Val Leu Asn Asn Ile Lys Met 
385                 390                 395                 400 


Ile Lys Tyr Tyr Thr Trp Glu Asp Ala Tyr Glu Lys Asn Ile Gln Asp 
                405                 410                 415     


Ile Arg Thr Lys Glu Ile Ser Lys Val Arg Lys Met Gln Leu Ser Arg 
            420                 425                 430         


Asn Phe Leu Ile Ala Met Ala Met Ser Leu Pro Ser Ile Ala Ser Leu 
        435                 440                 445             


Val Thr Phe Leu Ala Met Tyr Lys Val Asn Lys Gly Gly Arg Gln Pro 
    450                 455                 460                 


Gly Asn Ile Phe Ala Ser Leu Ser Leu Phe Gln Val Leu Ser Leu Gln 
465                 470                 475                 480 


Met Phe Phe Leu Pro Ile Ala Ile Gly Thr Gly Ile Asp Met Ile Ile 
                485                 490                 495     


Gly Leu Gly Arg Leu Gln Ser Leu Leu Glu Ala Pro Glu Asp Asp Pro 
            500                 505                 510         


Asn Gln Met Ile Glu Met Lys Pro Ser Pro Gly Phe Asp Pro Lys Leu 
        515                 520                 525             


Ala Leu Lys Met Thr His Cys Ser Phe Glu Trp Glu Asp Tyr Glu Leu 
    530                 535                 540                 


Asn Asp Ala Ile Glu Glu Ala Lys Gly Glu Ala Lys Asp Glu Gly Lys 
545                 550                 555                 560 


Lys Asn Lys Lys Lys Arg Lys Asp Thr Trp Gly Lys Pro Ser Ala Ser 
                565                 570                 575     


Thr Asn Lys Ala Lys Arg Leu Asp Asn Met Leu Lys Asp Arg Asp Gly 
            580                 585                 590         


Pro Glu Asp Leu Glu Lys Thr Ser Phe Arg Gly Phe Lys Asp Leu Asn 
        595                 600                 605             


Phe Asp Ile Lys Lys Gly Glu Phe Ile Met Ile Thr Gly Pro Ile Gly 
    610                 615                 620                 


Thr Gly Lys Ser Ser Leu Leu Asn Ala Met Ala Gly Ser Met Arg Lys 
625                 630                 635                 640 


Thr Asp Gly Lys Val Glu Val Asn Gly Asp Leu Leu Met Cys Gly Tyr 
                645                 650                 655     


Pro Trp Ile Gln Asn Ala Ser Val Arg Asp Asn Ile Ile Phe Gly Ser 
            660                 665                 670         


Pro Phe Asn Lys Glu Lys Tyr Asp Glu Val Val Arg Val Cys Ser Leu 
        675                 680                 685             


Lys Ala Asp Leu Asp Ile Leu Pro Ala Gly Asp Met Thr Glu Ile Gly 
    690                 695                 700                 


Glu Arg Gly Ile Thr Leu Ser Gly Gly Gln Lys Ala Arg Ile Asn Leu 
705                 710                 715                 720 


Ala Arg Ser Val Tyr Lys Lys Lys Asp Ile Tyr Leu Phe Asp Asp Val 
                725                 730                 735     


Leu Ser Ala Val Asp Ser Arg Val Gly Lys His Ile Met Asp Glu Cys 
            740                 745                 750         


Leu Thr Gly Met Leu Ala Asn Lys Thr Arg Ile Leu Ala Thr His Gln 
        755                 760                 765             


Leu Ser Leu Ile Glu Arg Ala Ser Arg Val Ile Val Leu Gly Thr Asp 
    770                 775                 780                 


Gly Gln Val Asp Ile Gly Thr Val Asp Glu Leu Lys Ala Arg Asn Gln 
785                 790                 795                 800 


Thr Leu Ile Asn Leu Leu Gln Phe Ser Ser Gln Asn Ser Glu Lys Glu 
                805                 810                 815     


Asp Glu Glu Gln Glu Ala Val Val Ala Gly Glu Leu Gly Gln Leu Lys 
            820                 825                 830         


Tyr Glu Ser Glu Val Lys Glu Leu Thr Glu Leu Lys Lys Lys Ala Thr 
        835                 840                 845             


Glu Met Ser Gln Thr Ala Asn Ser Gly Lys Ile Val Ala Asp Gly His 
    850                 855                 860                 


Thr Ser Ser Lys Glu Glu Arg Ala Val Asn Ser Ile Ser Leu Lys Ile 
865                 870                 875                 880 


Tyr Arg Glu Tyr Ile Lys Ala Ala Val Gly Lys Trp Gly Phe Ile Ala 
                885                 890                 895     


Leu Pro Leu Tyr Ala Ile Leu Val Val Gly Thr Thr Phe Cys Ser Leu 
            900                 905                 910         


Phe Ser Ser Val Trp Leu Ser Tyr Trp Thr Glu Asn Lys Phe Lys Asn 
        915                 920                 925             


Arg Pro Pro Ser Phe Tyr Met Gly Leu Tyr Ser Phe Phe Val Phe Ala 
    930                 935                 940                 


Ala Phe Ile Phe Met Asn Gly Gln Phe Thr Ile Leu Cys Ala Met Gly 
945                 950                 955                 960 


Ile Met Ala Ser Lys Trp Leu Asn Leu Arg Ala Val Lys Arg Ile Leu 
                965                 970                 975     


His Thr Pro Met Ser Tyr Ile Asp Thr Thr Pro Leu Gly Arg Ile Leu 
            980                 985                 990         


Asn Arg Phe Thr Lys Asp Thr Asp  Ser Leu Asp Asn Glu  Leu Thr Glu 
        995                 1000                 1005             


Ser Leu  Arg Leu Met Thr Ser  Gln Phe Ala Asn Ile  Val Gly Val 
    1010                 1015                 1020             


Cys Val  Met Cys Ile Val Tyr  Leu Pro Trp Phe Ala  Ile Ala Ile 
    1025                 1030                 1035             


Pro Phe  Leu Leu Val Ile Phe  Val Leu Ile Ala Asp  His Tyr Gln 
    1040                 1045                 1050             


Ser Ser  Gly Arg Glu Ile Lys  Arg Leu Glu Ala Val  Gln Arg Ser 
    1055                 1060                 1065             


Phe Val  Tyr Asn Asn Leu Asn  Glu Val Leu Gly Gly  Met Asp Thr 
    1070                 1075                 1080             


Ile Lys  Ala Tyr Arg Ser Gln  Glu Arg Phe Leu Ala  Lys Ser Asp 
    1085                 1090                 1095             


Phe Leu  Ile Asn Lys Met Asn  Glu Ala Gly Tyr Leu  Val Val Val 
    1100                 1105                 1110             


Leu Gln  Arg Trp Val Gly Ile  Phe Leu Asp Met Val  Ala Ile Ala 
    1115                 1120                 1125             


Phe Ala  Leu Ile Ile Thr Leu  Leu Cys Val Thr Arg  Ala Phe Pro 
    1130                 1135                 1140             


Ile Ser  Ala Ala Ser Val Gly  Val Leu Leu Thr Tyr  Val Leu Gln 
    1145                 1150                 1155             


Leu Pro  Gly Leu Leu Asn Thr  Ile Leu Arg Ala Met  Thr Gln Thr 
    1160                 1165                 1170             


Glu Asn  Asp Met Asn Ser Ala  Glu Arg Leu Val Thr  Tyr Ala Thr 
    1175                 1180                 1185             


Glu Leu  Pro Leu Glu Ala Ser  Tyr Arg Lys Pro Glu  Met Thr Pro 
    1190                 1195                 1200             


Pro Glu  Ser Trp Pro Ser Met  Gly Glu Ile Ile Phe  Glu Asn Val 
    1205                 1210                 1215             


Asp Phe  Ala Tyr Arg Pro Gly  Leu Pro Ile Val Leu  Lys Asn Leu 
    1220                 1225                 1230             


Asn Leu  Asn Ile Lys Ser Gly  Glu Lys Ile Gly Ile  Cys Gly Arg 
    1235                 1240                 1245             


Thr Gly  Ala Gly Lys Ser Thr  Ile Met Ser Ala Leu  Tyr Arg Leu 
    1250                 1255                 1260             


Asn Glu  Leu Thr Ala Gly Lys  Ile Leu Ile Asp Asn  Val Asp Ile 
    1265                 1270                 1275             


Ser Gln  Leu Gly Leu Phe Asp  Leu Arg Arg Lys Leu  Ala Ile Ile 
    1280                 1285                 1290             


Pro Gln  Asp Pro Val Leu Phe  Arg Gly Thr Ile Arg  Lys Asn Leu 
    1295                 1300                 1305             


Asp Pro  Phe Asn Glu Arg Thr  Asp Asp Glu Leu Trp  Asp Ala Leu 
    1310                 1315                 1320             


Val Arg  Gly Gly Ala Ile Ala  Lys Asp Asp Leu Pro  Glu Val Lys 
    1325                 1330                 1335             


Leu Gln  Lys Pro Asp Glu Asn  Gly Thr His Gly Lys  Met His Lys 
    1340                 1345                 1350             


Phe His  Leu Asp Gln Ala Val  Glu Glu Glu Gly Ser  Asn Phe Ser 
    1355                 1360                 1365             


Leu Gly  Glu Arg Gln Leu Leu  Ala Leu Thr Arg Ala  Leu Val Arg 
    1370                 1375                 1380             


Gln Ser  Lys Ile Leu Ile Leu  Asp Glu Ala Thr Ser  Ser Val Asp 
    1385                 1390                 1395             


Tyr Glu  Thr Asp Gly Lys Ile  Gln Thr Arg Ile Val  Glu Glu Phe 
    1400                 1405                 1410             


Gly Asp  Cys Thr Ile Leu Cys  Ile Ala His Arg Leu  Lys Thr Ile 
    1415                 1420                 1425             


Val Asn  Tyr Asp Arg Ile Leu  Val Leu Glu Lys Gly  Glu Val Ala 
    1430                 1435                 1440             


Glu Phe  Asp Thr Pro Trp Thr  Leu Phe Ser Gln Glu  Asp Ser Ile 
    1445                 1450                 1455             


Phe Arg  Ser Met Cys Ser Arg  Ser Gly Ile Val Glu  Asn Asp Phe 
    1460                 1465                 1470             


Glu Asn  Arg Ser 
    1475         


<210>  29
<211>  306
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  29

Met Ser Ser Val Glu Arg Ile Lys Glu Tyr Thr Asp Ile Pro Ser Glu 
1               5                   10                  15      


Ser Asn Gly Tyr Ile Ser Pro Pro Ala Asn Trp Pro Gln Thr Gly Asp 
            20                  25                  30          


Val Glu Leu Lys Asn Leu Ser Leu Arg Tyr Ser Pro His Ser Ser Lys 
        35                  40                  45              


Ala Leu Asp Asn Val Ser Phe Lys Val Lys Ala Gly Thr Lys Val Gly 
    50                  55                  60                  


Ile Val Gly Arg Thr Gly Ala Gly Lys Ser Ser Ile Ile Ala Ala Ile 
65                  70                  75                  80  


Tyr Arg Leu Ser Asp Trp Glu Asn Gly Thr Ile Thr Ile Asp Asn Lys 
                85                  90                  95      


Asp Ile Lys His Ile Pro Leu Glu Arg Leu Arg Asn Ser Ile Ser Cys 
            100                 105                 110         


Ile Pro Gln Asp Pro Thr Leu Phe Asp Gly Thr Val Arg Ser Asn Leu 
        115                 120                 125             


Asp Pro Phe Asp Arg Tyr Ser Asp Val Gln Ile Tyr Gly Val Leu Ser 
    130                 135                 140                 


Lys Val Gly Leu Ile Glu Glu Cys Asp Glu Leu Cys Leu Ile Phe Glu 
145                 150                 155                 160 


Gln Glu Gln Pro Asn Phe Ser Ser His Lys Leu Arg Asn Arg Phe Ile 
                165                 170                 175     


Asp Leu Asn Thr Val Val Lys Ser Gly Gly Ser Asn Leu Ser Gln Gly 
            180                 185                 190         


Gln Arg Gln Leu Leu Cys Leu Ala Arg Ser Met Leu Gly Ala Arg Asn 
        195                 200                 205             


Ile Met Leu Ile Asp Glu Ala Thr Ala Ser Ile Asp Tyr Ile Ser Asp 
    210                 215                 220                 


Ala Lys Ile Gln Lys Thr Ile Arg Glu Thr Met Lys Asn Thr Thr Ile 
225                 230                 235                 240 


Leu Thr Ile Ala His Arg Leu Arg Ser Val Ile Asp Tyr Asp Lys Ile 
                245                 250                 255     


Leu Val Met Glu Met Gly Arg Val Lys Glu Tyr Asp His Pro Tyr Thr 
            260                 265                 270         


Leu Ile Ser Asp Arg Asn Thr Ile Phe Tyr Arg Leu Cys Arg Gln Ser 
        275                 280                 285             


Gly Glu Phe Glu Asn Leu Phe Glu Leu Ala Lys Val Ser Phe Asp Asn 
    290                 295                 300                 


Lys Arg 
305     


<210>  30
<211>  1294
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  30

Met Ser Gln Gln Glu Asn Gly Asp Val Ala Thr Glu Leu Ile Glu Asn 
1               5                   10                  15      


Arg Leu Ser Phe Ser Arg Ile Pro Arg Ile Ser Leu His Val Arg Asp 
            20                  25                  30          


Leu Ser Ile Val Ala Ser Lys Thr Asn Thr Thr Leu Val Asn Thr Phe 
        35                  40                  45              


Ser Met Asp Leu Pro Ser Gly Ser Val Met Ala Val Met Gly Gly Ser 
    50                  55                  60                  


Gly Ser Gly Lys Thr Thr Leu Leu Asn Val Leu Ala Ser Lys Ile Ser 
65                  70                  75                  80  


Gly Gly Leu Thr His Asn Gly Ser Ile Arg Tyr Val Leu Glu Asp Thr 
                85                  90                  95      


Gly Ser Glu Pro Asn Glu Thr Glu Pro Lys Arg Ala His Leu Asp Gly 
            100                 105                 110         


Gln Asp His Pro Ile Gln Lys His Val Ile Met Ala Tyr Leu Pro Gln 
        115                 120                 125             


Gln Asp Val Leu Ser Pro Arg Leu Thr Cys Arg Glu Thr Leu Lys Phe 
    130                 135                 140                 


Ala Ala Asp Leu Lys Leu Asn Ser Ser Glu Arg Thr Lys Lys Leu Met 
145                 150                 155                 160 


Val Glu Gln Leu Ile Glu Glu Leu Gly Leu Lys Asp Cys Ala Asp Thr 
                165                 170                 175     


Leu Val Gly Asp Asn Ser His Arg Gly Leu Ser Gly Gly Glu Lys Arg 
            180                 185                 190         


Arg Leu Ser Ile Gly Thr Gln Met Ile Ser Asn Pro Ser Ile Met Phe 
        195                 200                 205             


Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Tyr Ser Ala Phe Leu Val 
    210                 215                 220                 


Ile Lys Thr Leu Lys Lys Leu Ala Lys Glu Asp Gly Arg Thr Phe Ile 
225                 230                 235                 240 


Met Ser Ile His Gln Pro Arg Ser Asp Ile Leu Phe Leu Leu Asp Gln 
                245                 250                 255     


Val Cys Ile Leu Ser Lys Gly Asn Val Val Tyr Cys Asp Lys Met Asp 
            260                 265                 270         


Asn Thr Ile Pro Tyr Phe Glu Ser Ile Gly Tyr His Val Pro Gln Leu 
        275                 280                 285             


Val Asn Pro Ala Asp Tyr Phe Ile Asp Leu Ser Ser Val Asp Ser Arg 
    290                 295                 300                 


Ser Asp Lys Glu Glu Ala Ala Thr Gln Ser Arg Leu Asn Ser Leu Ile 
305                 310                 315                 320 


Asp His Trp His Asp Tyr Glu Arg Thr His Leu Gln Leu Gln Ala Glu 
                325                 330                 335     


Ser Tyr Ile Ser Asn Ala Thr Glu Ile Gln Ile Gln Asn Met Thr Thr 
            340                 345                 350         


Arg Leu Pro Phe Trp Lys Gln Val Thr Val Leu Thr Arg Arg Asn Phe 
        355                 360                 365             


Lys Leu Asn Phe Ser Asp Tyr Val Thr Leu Ile Ser Thr Phe Ala Glu 
    370                 375                 380                 


Pro Leu Ile Ile Gly Thr Val Cys Gly Trp Ile Tyr Tyr Lys Pro Asp 
385                 390                 395                 400 


Lys Ser Ser Ile Gly Gly Leu Arg Thr Thr Thr Ala Cys Leu Tyr Ala 
                405                 410                 415     


Ser Thr Ile Leu Gln Cys Tyr Leu Tyr Leu Leu Phe Asp Thr Tyr Arg 
            420                 425                 430         


Leu Cys Glu Gln Asp Ile Ala Leu Tyr Asp Arg Glu Arg Ala Glu Gly 
        435                 440                 445             


Ser Val Thr Pro Leu Ala Phe Ile Val Ala Arg Lys Ile Ser Leu Phe 
    450                 455                 460                 


Leu Ser Asp Asp Phe Ala Met Thr Met Ile Phe Val Ser Ile Thr Tyr 
465                 470                 475                 480 


Phe Met Phe Gly Leu Glu Ala Asp Ala Arg Lys Phe Phe Tyr Gln Phe 
                485                 490                 495     


Ala Val Val Phe Leu Cys Gln Leu Ser Cys Ser Gly Leu Ser Met Leu 
            500                 505                 510         


Ser Val Ala Val Ser Arg Asp Phe Ser Lys Ala Ser Leu Val Gly Asn 
        515                 520                 525             


Met Thr Phe Thr Val Leu Ser Met Gly Cys Gly Phe Phe Val Asn Ala 
    530                 535                 540                 


Lys Val Met Pro Val Tyr Val Arg Trp Ile Lys Tyr Ile Ala Phe Thr 
545                 550                 555                 560 


Trp Tyr Ser Phe Gly Thr Leu Met Ser Ser Thr Phe Thr Asn Ser Tyr 
                565                 570                 575     


Cys Thr Thr Asp Asn Leu Asp Glu Cys Leu Gly Asn Gln Ile Leu Glu 
            580                 585                 590         


Val Tyr Gly Phe Pro Arg Asn Trp Ile Thr Val Pro Ala Val Val Leu 
        595                 600                 605             


Leu Cys Trp Ser Val Gly Tyr Phe Val Val Gly Ala Ile Ile Leu Tyr 
    610                 615                 620                 


Leu His Lys Ile Asp Ile Thr Leu Gln Asn Glu Val Lys Ser Lys Gln 
625                 630                 635                 640 


Lys Lys Ile Lys Lys Lys Ser Pro Thr Gly Met Lys Pro Glu Ile Gln 
                645                 650                 655     


Leu Leu Asp Asp Val Tyr His Gln Lys Asp Leu Glu Ala Glu Lys Gly 
            660                 665                 670         


Lys Asn Ile His Ile Thr Ile Lys Leu Glu Asp Ile Asp Leu Arg Val 
        675                 680                 685             


Ile Phe Ser Ala Pro Phe Ser Asn Trp Lys Glu Gly Asn Phe His His 
    690                 695                 700                 


Glu Thr Lys Glu Ile Leu Gln Ser Val Asn Ala Ile Phe Lys Pro Gly 
705                 710                 715                 720 


Met Ile Asn Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Ser Leu 
                725                 730                 735     


Leu Asn Leu Ile Ser Gly Arg Leu Lys Ser Ser Val Phe Ala Lys Phe 
            740                 745                 750         


Asp Thr Ser Gly Ser Ile Met Phe Asn Asp Ile Gln Val Ser Glu Leu 
        755                 760                 765             


Met Phe Lys Asn Val Cys Ser Tyr Val Ser Gln Asp Asp Asp His Leu 
    770                 775                 780                 


Leu Ala Ala Leu Thr Val Lys Glu Thr Leu Lys Tyr Ala Ala Ala Leu 
785                 790                 795                 800 


Arg Leu His His Leu Thr Glu Ala Glu Arg Met Glu Arg Thr Asp Asn 
                805                 810                 815     


Leu Ile Arg Ser Leu Gly Leu Lys His Cys Glu Asn Asn Ile Ile Gly 
            820                 825                 830         


Asn Glu Phe Val Lys Gly Ile Ser Gly Gly Glu Lys Arg Arg Val Thr 
        835                 840                 845             


Met Gly Val Gln Leu Leu Asn Asp Pro Pro Ile Leu Leu Leu Asp Glu 
    850                 855                 860                 


Pro Thr Ser Gly Leu Asp Ser Phe Thr Ser Ala Thr Ile Leu Glu Ile 
865                 870                 875                 880 


Leu Glu Lys Leu Cys Arg Glu Gln Gly Lys Thr Ile Ile Ile Thr Ile 
                885                 890                 895     


His Gln Pro Arg Ser Glu Leu Phe Lys Arg Phe Gly Asn Val Leu Leu 
            900                 905                 910         


Leu Ala Lys Ser Gly Arg Thr Ala Phe Asn Gly Ser Pro Asp Glu Met 
        915                 920                 925             


Ile Ala Tyr Phe Thr Glu Leu Gly Tyr Asn Cys Pro Ser Phe Thr Asn 
    930                 935                 940                 


Val Ala Asp Phe Phe Leu Asp Leu Ile Ser Val Asn Thr Gln Asn Glu 
945                 950                 955                 960 


Gln Asn Glu Ile Ser Ser Arg Ala Arg Val Glu Lys Ile Leu Ser Ala 
                965                 970                 975     


Trp Lys Ala Asn Met Asp Asn Glu Ser Leu Ser Pro Thr Pro Ile Ser 
            980                 985                 990         


Glu Lys Gln Gln Tyr Ser Gln Glu  Ser Phe Phe Thr Glu  Tyr Ser Glu 
        995                 1000                 1005             


Phe Val  Arg Lys Pro Ala Asn  Leu Val Leu Ala Tyr  Ile Val Asn 
    1010                 1015                 1020             


Val Lys  Arg Gln Phe Thr Thr  Thr Arg Arg Ser Phe  Asp Ser Leu 
    1025                 1030                 1035             


Met Ala  Arg Ile Ala Gln Ile  Pro Gly Leu Gly Val  Ile Phe Ala 
    1040                 1045                 1050             


Leu Phe  Phe Ala Pro Val Lys  His Asn Tyr Thr Ser  Ile Ser Asn 
    1055                 1060                 1065             


Arg Leu  Gly Leu Ala Gln Glu  Ser Thr Ala Leu Tyr  Phe Val Gly 
    1070                 1075                 1080             


Met Leu  Gly Asn Leu Ala Cys  Tyr Pro Thr Glu Arg  Asp Tyr Phe 
    1085                 1090                 1095             


Tyr Glu  Glu Tyr Asn Asp Asn  Val Tyr Gly Ile Ala  Pro Phe Phe 
    1100                 1105                 1110             


Leu Ala  Tyr Met Thr Leu Glu  Leu Pro Leu Ser Ala  Leu Ala Ser 
    1115                 1120                 1125             


Val Leu  Tyr Ala Val Phe Thr  Val Leu Ala Cys Gly  Leu Pro Arg 
    1130                 1135                 1140             


Thr Ala  Gly Asn Phe Phe Ala  Thr Val Tyr Cys Ser  Phe Ile Val 
    1145                 1150                 1155             


Thr Cys  Cys Gly Glu Ala Leu  Gly Ile Met Thr Asn  Thr Phe Phe 
    1160                 1165                 1170             


Glu Arg  Pro Gly Phe Val Val  Asn Cys Ile Ser Ile  Ile Leu Ser 
    1175                 1180                 1185             


Ile Gly  Thr Gln Met Ser Gly  Leu Met Ser Leu Gly  Met Ser Arg 
    1190                 1195                 1200             


Val Leu  Lys Gly Phe Asn Tyr  Leu Asn Pro Val Gly  Tyr Thr Ser 
    1205                 1210                 1215             


Met Ile  Ile Ile Asn Phe Ala  Phe Pro Gly Asn Leu  Lys Leu Thr 
    1220                 1225                 1230             


Cys Glu  Asp Gly Gly Lys Asn  Ser Asp Gly Thr Cys  Glu Phe Ala 
    1235                 1240                 1245             


Asn Gly  His Asp Val Leu Val  Ser Tyr Gly Leu Val  Arg Asn Thr 
    1250                 1255                 1260             


Gln Lys  Tyr Leu Gly Ile Ile  Val Cys Val Ala Ile  Ile Tyr Arg 
    1265                 1270                 1275             


Leu Ile  Ala Phe Phe Ile Leu  Lys Ala Lys Leu Glu  Trp Ile Lys 
    1280                 1285                 1290             


Trp 
    


<210>  31
<211>  586
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  31

Met Ser Arg Ser Asn Ser Ile Tyr Thr Glu Asp Ile Glu Met Tyr Pro 
1               5                   10                  15      


Thr His Asn Glu Gln His Leu Thr Arg Glu Tyr Thr Lys Pro Asp Gly 
            20                  25                  30          


Gln Thr Lys Ser Glu Lys Leu Asn Phe Glu Gly Ala Tyr Ile Asn Ser 
        35                  40                  45              


His Gly Thr Leu Ser Lys Thr Thr Thr Arg Glu Ile Glu Gly Asp Leu 
    50                  55                  60                  


Asp Ser Glu Thr Ser Ser His Ser Ser Asp Asp Lys Val Asp Pro Thr 
65                  70                  75                  80  


Gln Gln Ile Thr Ala Glu Thr Lys Ala Pro Tyr Thr Leu Leu Ser Tyr 
                85                  90                  95      


Gly Gln Lys Trp Gly Met Val Ala Ile Leu Thr Met Cys Gly Phe Trp 
            100                 105                 110         


Ser Ser Leu Gly Ser Pro Ile Tyr Tyr Pro Ala Leu Arg Gln Leu Glu 
        115                 120                 125             


Lys Gln Phe Asn Val Asp Glu Asn Met Val Asn Val Thr Val Val Val 
    130                 135                 140                 


Tyr Leu Leu Phe Gln Gly Ile Ser Pro Thr Val Ser Gly Gly Leu Ala 
145                 150                 155                 160 


Asp Cys Phe Gly Arg Arg Pro Ile Ile Leu Ala Gly Met Leu Ile Tyr 
                165                 170                 175     


Val Ile Ala Ser Ile Gly Leu Ala Cys Ala Pro Ser Tyr Gly Val Ile 
            180                 185                 190         


Ile Phe Leu Arg Cys Ile Gln Ser Ile Gly Ile Ser Pro Thr Ile Ala 
        195                 200                 205             


Ile Ser Ser Gly Val Val Gly Asp Phe Thr Leu Lys His Glu Arg Gly 
    210                 215                 220                 


Thr Phe Val Gly Ala Thr Ser Gly Phe Val Leu Leu Gly Gln Cys Phe 
225                 230                 235                 240 


Gly Ser Leu Ile Gly Ala Val Leu Thr Ala Arg Trp Asp Trp Arg Ala 
                245                 250                 255     


Ile Phe Trp Phe Leu Thr Ile Gly Cys Gly Ser Cys Phe Leu Ile Ala 
            260                 265                 270         


Phe Leu Ile Leu Pro Glu Thr Lys Arg Thr Ile Ala Gly Asn Leu Ser 
        275                 280                 285             


Ile Lys Pro Lys Arg Phe Ile Asn Arg Ala Pro Ile Phe Leu Leu Gly 
    290                 295                 300                 


Pro Val Arg Arg Arg Phe Lys Tyr Asp Asn Pro Asp Tyr Glu Thr Leu 
305                 310                 315                 320 


Asp Pro Thr Ile Pro Lys Leu Asp Leu Ser Ser Ala Gly Lys Ile Leu 
                325                 330                 335     


Val Leu Pro Glu Ile Ile Leu Ser Leu Phe Pro Ser Gly Leu Leu Phe 
            340                 345                 350         


Ala Met Trp Thr Leu Met Leu Ser Ser Ile Ser Ser Gly Leu Ser Val 
        355                 360                 365             


Ala Pro Tyr Asn Tyr His Leu Val Ile Ile Gly Val Cys Tyr Leu Pro 
    370                 375                 380                 


Gly Gly Ile Gly Gly Leu Met Gly Ser Phe Phe Thr Gly Arg Ile Ile 
385                 390                 395                 400 


Asp Met Tyr Phe Lys Arg Lys Ile Lys Lys Phe Glu Gln Asp Lys Ala 
                405                 410                 415     


Asn Gly Leu Ile Pro Gln Asp Ala Glu Ile Asn Met Phe Lys Val Arg 
            420                 425                 430         


Leu Val Cys Leu Leu Pro Gln Asn Phe Leu Ala Val Val Ala Tyr Leu 
        435                 440                 445             


Leu Phe Gly Trp Ser Ile Asp Lys Gly Trp Arg Ile Glu Ser Ile Leu 
    450                 455                 460                 


Ile Thr Ser Phe Val Cys Ser Tyr Cys Ala Met Ser Thr Leu Ser Thr 
465                 470                 475                 480 


Ser Thr Thr Leu Leu Val Asp Leu Tyr Pro Thr Lys Ser Ser Thr Ala 
                485                 490                 495     


Ser Ser Cys Phe Asn Phe Val Arg Cys Ser Leu Ser Thr Ile Phe Met 
            500                 505                 510         


Gly Cys Phe Ala Lys Met Lys Ala Ala Met Thr Val Gly Gly Thr Phe 
        515                 520                 525             


Thr Phe Leu Cys Ala Leu Val Phe Phe Phe Asn Phe Leu Met Phe Ile 
    530                 535                 540                 


Pro Met Lys Tyr Gly Met Lys Trp Arg Glu Asp Arg Leu Leu Lys Gln 
545                 550                 555                 560 


Gln Arg Gln Ser Trp Leu Asn Thr Leu Ala Val Lys Ala Lys Lys Gly 
                565                 570                 575     


Thr Lys Arg Asp Gln Asn Asp Asn His Asn 
            580                 585     


<210>  32
<211>  613
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  32

Met Lys Gly Glu Pro Lys Thr Tyr Ser Met Ser Asp Leu Ser Tyr Tyr 
1               5                   10                  15      


Gly Glu Lys Ala Gln Gln Gln Asn Glu Lys Gln Gln Lys Gln Tyr Val 
            20                  25                  30          


Val Arg Arg Asn Ser Thr Gln Ser Thr Ser Lys Gln Asn Val Ser Val 
        35                  40                  45              


Val Leu Glu Asp Asn Ala Ser Glu Ser Asn Glu Leu Pro Lys Gly Phe 
    50                  55                  60                  


Ile Leu Tyr Ala Ser Leu Ile Ala Leu Ala Leu Ser Leu Phe Leu Ala 
65                  70                  75                  80  


Ala Leu Asp Ile Met Ile Val Ser Thr Ile Ile Glu Glu Val Ala Lys 
                85                  90                  95      


Gln Phe Gly Ser Tyr Ser Glu Ile Gly Trp Leu Phe Thr Gly Tyr Ser 
            100                 105                 110         


Leu Pro Asn Ala Leu Leu Ala Leu Ile Trp Gly Arg Ile Ala Thr Pro 
        115                 120                 125             


Ile Gly Phe Lys Glu Thr Met Leu Phe Ala Ile Val Ile Phe Glu Ile 
    130                 135                 140                 


Gly Ser Leu Ile Ser Ala Leu Ala Asn Ser Met Ser Met Leu Ile Gly 
145                 150                 155                 160 


Gly Arg Val Ile Ala Gly Val Gly Gly Cys Gly Ile Gln Ser Leu Ser 
                165                 170                 175     


Phe Val Ile Gly Ser Thr Leu Val Glu Glu Ser Gln Arg Gly Ile Leu 
            180                 185                 190         


Ile Ala Val Leu Ser Cys Ser Phe Ala Ile Ala Ser Val Val Gly Pro 
        195                 200                 205             


Phe Leu Gly Gly Val Phe Thr Ser Ser Val Thr Trp Arg Trp Cys Phe 
    210                 215                 220                 


Tyr Val Asn Leu Pro Ile Gly Gly Leu Ala Phe Phe Leu Phe Leu Phe 
225                 230                 235                 240 


Phe Tyr Asn Pro Gly Leu Ser Thr Phe Gln Glu Thr Met Asp Asn Ile 
                245                 250                 255     


Arg Lys Phe Pro Ser Gln Phe Ile Glu Ile Val Arg Asn Val Ala Tyr 
            260                 265                 270         


His Leu Leu Lys Ile Lys Gly Phe Ser Lys Leu Asn Gly Trp Arg Lys 
        275                 280                 285             


Pro Phe Met Glu Leu Ile Phe Met Tyr Asp Ile Ile Glu Phe Val Phe 
    290                 295                 300                 


Cys Ser Ala Gly Phe Thr Cys Ile Leu Leu Ala Phe Thr Phe Gly Gly 
305                 310                 315                 320 


Asn Arg Tyr Ala Trp Asn Ser Ala Ser Ile Ile Ile Leu Phe Ile Ile 
                325                 330                 335     


Gly Ile Val Leu Val Val Leu Ala Gly Ile Tyr Asp Phe Leu Val Phe 
            340                 345                 350         


Pro Lys Phe Asn Ile Val Lys Ala Thr Pro His Tyr Gln Pro Leu Met 
        355                 360                 365             


Ser Trp Thr Asn Ile Lys Lys Pro Gly Ile Phe Thr Val Asn Ile Ala 
    370                 375                 380                 


Leu Phe Leu Thr Cys Ala Gly Tyr Ile Ser Gln Phe Thr Tyr Ile Val 
385                 390                 395                 400 


Gln Tyr Phe Gln Leu Ile Tyr Asn Asp Ser Ala Trp Arg Ala Ala Val 
                405                 410                 415     


His Leu Val Ala Cys Ile Ile Ser Thr Val Val Thr Ala Ile Leu Cys 
            420                 425                 430         


Gly Ala Ile Thr Asp Lys Thr Arg Gln Ile Lys Pro Ile Ile Val Ile 
        435                 440                 445             


Ser Ser Ile Phe Gly Val Val Gly Ala Gly Ile Leu Thr Leu Leu Asn 
    450                 455                 460                 


Asn Asn Ala Asn Asn Ser Ala His Ile Gly Leu Leu Ile Leu Pro Gly 
465                 470                 475                 480 


Val Ala Phe Gly Gly Leu Ala Gln Ser Ser Met Leu Ala Ser Gln Ile 
                485                 490                 495     


Gln Leu Asp Lys Lys Ser Pro Thr Phe Arg Ser Asp Phe Val Ser Ile 
            500                 505                 510         


Thr Thr Phe Asn Thr Phe Cys Lys Asn Leu Gly Gln Ala Leu Gly Gly 
        515                 520                 525             


Val Ile Ser Asn Thr Val Phe Ser Ala Ala Ala Ile Lys Lys Leu Thr 
    530                 535                 540                 


Lys Ala Asn Ile Gln Leu Pro Asp Gly Thr Thr Val Asp Asn Leu Val 
545                 550                 555                 560 


Ile Tyr Arg Gln Thr Asn Phe Asp Gly Ser His Ser Lys Leu Gly Asn 
                565                 570                 575     


Ile Ile Ser Glu Ser Leu Thr Asp Val Phe Tyr Met Ala Leu Gly Phe 
            580                 585                 590         


Tyr Ala Leu Ser Leu Ile Phe Ala Val Phe Ala Ser Asn Lys Lys Val 
        595                 600                 605             


Thr Ala Ser Leu Arg 
    610             


<210>  33
<211>  572
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Gly Ser Glu Pro Phe Gln Lys Lys Asn Leu Gly Leu Gln Ile Asn 
1               5                   10                  15      


Ser Gln Glu Ser Gly Thr Thr Arg Ser Thr Phe His Ser Leu Glu Asp 
            20                  25                  30          


Leu Gly Asp Asp Val Ile Asn Glu Ser Trp Asp Gln Val Asn Gln Lys 
        35                  40                  45              


Arg Ala Asn Ile Asp His Asp Val Phe His Glu His Pro Asp Ser Ser 
    50                  55                  60                  


Pro Ser Leu Ser Ala Gln Lys Ala Lys Thr Lys Glu Glu Glu Val Ala 
65                  70                  75                  80  


Val Lys Ser Ser Asn Ser Gln Ser Arg Asp Pro Ser Pro Asp Thr Gln 
                85                  90                  95      


Ala His Ile Pro Tyr Thr Tyr Phe Ser Lys Asp Gln Arg Leu Ile Ile 
            100                 105                 110         


Phe Gly Ile Ile Ile Phe Ile Gly Phe Leu Gly Pro Met Ser Gly Asn 
        115                 120                 125             


Ile Tyr Ile Pro Ala Leu Pro Leu Leu Gln Arg Glu Tyr Asp Val Ser 
    130                 135                 140                 


Ala Thr Thr Ile Asn Ala Thr Val Ser Val Phe Met Ala Val Phe Ser 
145                 150                 155                 160 


Val Gly Pro Leu Phe Trp Gly Ala Leu Ala Asp Phe Gly Gly Arg Lys 
                165                 170                 175     


Phe Leu Tyr Met Val Ser Leu Ser Leu Met Leu Ile Val Asn Ile Leu 
            180                 185                 190         


Leu Ala Ala Val Pro Val Asn Ile Ala Ala Leu Phe Val Leu Arg Ile 
        195                 200                 205             


Phe Gln Ala Phe Ala Ser Ser Ser Val Ile Ser Leu Gly Ala Gly Thr 
    210                 215                 220                 


Val Thr Asp Val Val Pro Pro Lys His Arg Gly Lys Ala Ile Ala Tyr 
225                 230                 235                 240 


Phe Met Met Gly Pro Asn Met Gly Pro Ile Ile Ala Pro Ile Val Ala 
                245                 250                 255     


Gly Leu Ile Leu Met Lys Gly Asn Tyr Trp Arg Trp Leu Phe Gly Phe 
            260                 265                 270         


Thr Ser Ile Met Thr Gly Ile Ala Leu Ile Leu Val Thr Ala Leu Leu 
        275                 280                 285             


Pro Glu Thr Leu Arg Cys Ile Val Gly Asn Gly Asp Pro Lys Trp Gly 
    290                 295                 300                 


Asp Lys Lys Asp Glu Arg Glu Asn Asn Glu Ser Pro Phe Phe Glu Gly 
305                 310                 315                 320 


Asn Lys Ile Ser His Arg Arg Leu Phe Pro Asp Ile Gly Ile Arg Lys 
                325                 330                 335     


Pro Val Asn Asn Asp Ala Phe Phe Gln Glu Asn Phe Pro Lys Pro Pro 
            340                 345                 350         


Lys Ala Gly Leu Thr Leu Tyr Trp Lys Met Ile Lys Cys Pro Pro Ile 
        355                 360                 365             


Ile Ile Thr Ser Val Ser Thr Ala Leu Leu Phe Ser Ser Tyr Tyr Ala 
    370                 375                 380                 


Phe Ser Val Thr Phe Ser Tyr Tyr Leu Glu His Asp Tyr Arg Phe Thr 
385                 390                 395                 400 


Met Leu Glu Ile Gly Ala Ala Tyr Val Cys Pro Gly Val Ala Met Leu 
                405                 410                 415     


Leu Gly Ser Gln Ser Gly Gly His Leu Ser Asp Tyr Leu Arg Ser Arg 
            420                 425                 430         


Trp Ile Lys Ser His Pro Lys Lys Lys Phe Pro Ala Glu Phe Arg Leu 
        435                 440                 445             


Leu Leu Asn Leu Ile Gly Ile Leu Leu Thr Ile Cys Gly Thr Ile Gly 
    450                 455                 460                 


Tyr Gly Trp Ala Ile Phe Phe His Tyr His Phe Val Val Leu Leu Val 
465                 470                 475                 480 


Phe Ser Ala Leu Thr Ala Phe Gly Met Thr Trp Cys Ser Asn Thr Ser 
                485                 490                 495     


Met Thr Tyr Leu Thr Glu Leu Phe Pro Lys Arg Ala Ala Gly Thr Val 
            500                 505                 510         


Ala Val Ser Ser Phe Phe Arg Asn Val Gly Ala Ala Ile Ser Ser Ala 
        515                 520                 525             


Ile Ile Leu Gln Leu Cys Asn Ala Met Gly Ile Gly Trp Cys Phe Thr 
    530                 535                 540                 


Gly Leu Gly Leu Cys Ser Ser Ile Ser Leu Ile Gly Ile Leu Tyr Leu 
545                 550                 555                 560 


Leu Ile Phe Gln Arg Lys Tyr Thr Ala Lys Glu Phe 
                565                 570         


<210>  34
<211>  548
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  34

Met Val Tyr Thr Ser Thr Tyr Arg His Thr Ile Val Val Asp Leu Leu 
1               5                   10                  15      


Glu Tyr Leu Gly Ile Val Ser Asn Leu Glu Thr Leu Gln Ser Ala Arg 
            20                  25                  30          


Glu Asp Glu Thr Arg Lys Pro Glu Asn Thr Asp Lys Lys Glu Cys Lys 
        35                  40                  45              


Pro Asp Tyr Asp Ile Glu Cys Gly Pro Asn Arg Ser Cys Ser Glu Ser 
    50                  55                  60                  


Ser Thr Asp Ser Asp Ser Ser Gly Ser Gln Ile Glu Lys Asn Asp Pro 
65                  70                  75                  80  


Phe Arg Val Asp Trp Asn Gly Pro Ser Asp Pro Glu Asn Pro Gln Asn 
                85                  90                  95      


Trp Pro Leu Leu Lys Lys Ser Leu Val Val Phe Gln Ile Met Leu Leu 
            100                 105                 110         


Thr Cys Val Thr Tyr Met Gly Ser Ser Ile Tyr Thr Pro Gly Gln Glu 
        115                 120                 125             


Tyr Ile Gln Glu Glu Phe His Val Gly His Val Val Ala Thr Leu Asn 
    130                 135                 140                 


Leu Ser Leu Tyr Val Leu Gly Tyr Gly Leu Gly Pro Ile Ile Phe Ser 
145                 150                 155                 160 


Pro Leu Ser Glu Thr Ala Arg Tyr Gly Arg Leu Asn Leu Tyr Met Val 
                165                 170                 175     


Thr Leu Phe Phe Phe Met Ile Phe Gln Val Gly Cys Ala Thr Val His 
            180                 185                 190         


Asn Ile Gly Gly Leu Ile Val Met Arg Phe Ile Ser Gly Ile Leu Cys 
        195                 200                 205             


Ser Pro Ser Leu Ala Thr Gly Gly Gly Thr Val Ala Asp Ile Ile Ser 
    210                 215                 220                 


Pro Glu Met Val Pro Leu Val Leu Gly Met Trp Ser Ala Gly Ala Val 
225                 230                 235                 240 


Ala Ala Pro Val Leu Ala Pro Leu Leu Gly Ala Ala Met Val Asp Ala 
                245                 250                 255     


Lys Asn Trp Arg Phe Ile Phe Trp Leu Leu Met Trp Leu Ser Ala Ala 
            260                 265                 270         


Thr Phe Ile Leu Leu Ala Phe Phe Phe Pro Glu Thr Gln His His Asn 
        275                 280                 285             


Ile Leu Tyr Arg Arg Ala Leu Lys Leu Arg Lys Glu Thr Gly Asp Asp 
    290                 295                 300                 


Arg Tyr Tyr Thr Glu Gln Asp Lys Leu Asp Arg Glu Val Asp Ala Arg 
305                 310                 315                 320 


Thr Phe Leu Ile Asn Thr Leu Tyr Arg Pro Leu Lys Met Ile Ile Lys 
                325                 330                 335     


Glu Pro Ala Ile Leu Ala Phe Asp Leu Tyr Ile Ala Val Ala Tyr Gly 
            340                 345                 350         


Cys Phe Tyr Leu Phe Phe Glu Ala Phe Pro Ile Val Phe Val Gly Ile 
        355                 360                 365             


Tyr His Phe Ser Leu Val Glu Val Gly Leu Ala Tyr Met Gly Phe Cys 
    370                 375                 380                 


Val Gly Cys Val Leu Ala Tyr Gly Leu Phe Gly Ile Leu Asn Met Arg 
385                 390                 395                 400 


Ile Ile Val Pro Arg Phe Arg Asn Gly Thr Phe Thr Pro Glu Ala Phe 
                405                 410                 415     


Leu Ile Val Ala Met Cys Val Cys Trp Cys Leu Pro Leu Ser Leu Phe 
            420                 425                 430         


Leu Phe Gly Trp Thr Ala Arg Val His Trp Ile Leu Pro Val Ile Ser 
        435                 440                 445             


Glu Val Phe Phe Val Leu Ala Val Phe Asn Ile Phe Gln Ala Thr Phe 
    450                 455                 460                 


Ala Tyr Leu Ala Thr Cys Tyr Pro Lys Tyr Val Ala Ser Val Phe Ala 
465                 470                 475                 480 


Gly Asn Gly Phe Cys Arg Ala Ser Phe Ala Cys Ala Phe Pro Leu Phe 
                485                 490                 495     


Gly Arg Ala Met Tyr Asp Asn Leu Ala Thr Lys Asn Tyr Pro Val Ala 
            500                 505                 510         


Trp Gly Ser Ser Leu Val Gly Phe Leu Thr Leu Gly Leu Ala Ile Ile 
        515                 520                 525             


Pro Phe Ile Leu Tyr Lys Tyr Gly Pro Ser Leu Arg Thr Arg Ser Ser 
    530                 535                 540                 


Tyr Thr Glu Glu 
545             


<210>  35
<211>  586
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Met Asp Lys Tyr Thr Asn Arg Asp His Pro Asp Tyr Ile Pro Gly Thr 
1               5                   10                  15      


Phe Asn Ile Tyr Ser Ser Gln Asn Leu Glu Asn Gly Ile Ile Tyr Glu 
            20                  25                  30          


Ser Lys Leu Lys Lys Thr Ser Ser Gly Val Val Leu Ile Pro Gln Pro 
        35                  40                  45              


Ser Tyr Ser Pro Asn Asp Pro Leu Asn Trp Ser Ser Trp Arg Lys Leu 
    50                  55                  60                  


Ala His Phe Gly Leu Met Ala Phe Ile Thr Ala Phe Thr Ala Ala Thr 
65                  70                  75                  80  


Ser Asn Asp Ala Gly Ala Ala Gln Asp Ser Leu Asn Glu Ile Tyr Gly 
                85                  90                  95      


Ile Ser Tyr Asp Ser Met Asn Thr Gly Ala Gly Val Leu Phe Leu Gly 
            100                 105                 110         


Ile Gly Trp Ser Thr Leu Phe Leu Ala Pro Phe Ala Asn Leu Tyr Gly 
        115                 120                 125             


Arg Lys Ile Thr Tyr Ile Val Cys Thr Thr Leu Gly Leu Phe Gly Ala 
    130                 135                 140                 


Leu Trp Phe Ala Leu Ala Lys Arg Thr Ser Asp Thr Ile Trp Ser Gln 
145                 150                 155                 160 


Leu Phe Val Gly Ile Ser Glu Ser Cys Ala Glu Ala Gln Val Gln Leu 
                165                 170                 175     


Ser Leu Ser Asp Ile Phe Phe Gln His Gln Leu Gly Ser Val Leu Thr 
            180                 185                 190         


Val Tyr Ile Met Cys Thr Ser Ile Gly Thr Phe Leu Gly Pro Leu Ile 
        195                 200                 205             


Ala Gly Tyr Ile Ser Ala Phe Thr Asn Phe Arg Trp Val Gly Trp Val 
    210                 215                 220                 


Ala Val Ile Ile Ser Gly Gly Leu Leu Ile Thr Ile Ile Phe Gly Cys 
225                 230                 235                 240 


Glu Glu Thr Tyr Phe Asp Arg Gly Gln Tyr Met Thr Pro Leu Thr Ser 
                245                 250                 255     


Cys Gln Ser Gly Tyr Glu Asp Gly Thr Thr Leu Gln Asn Ser Asp Asn 
            260                 265                 270         


Thr Ala Val Ser Arg Arg Lys Arg His Leu Asp Ala Lys Leu Ser Thr 
        275                 280                 285             


Pro Gly Ala Met Gly Glu Lys Gly Val Asp Leu Ser Glu Thr Ala Glu 
    290                 295                 300                 


Phe Glu Val Asn Asn Glu Glu Glu Val Thr Ile Pro Glu Thr Arg Glu 
305                 310                 315                 320 


Leu Ile Asp Gly Ser Lys Glu His Leu Lys Pro Tyr Pro Lys Arg Val 
                325                 330                 335     


Ala Ile Leu Thr Lys Ala Thr Asn Leu Lys Gly Tyr Gly Phe Lys Gln 
            340                 345                 350         


Tyr Phe Lys Tyr Leu Lys Ile Asn Leu Arg Met Phe Leu Phe Pro Pro 
        355                 360                 365             


Val Trp Leu Ser Gly Met Phe Trp Gly Ile Gln Asp Val Phe Leu Thr 
    370                 375                 380                 


Phe Tyr Leu Thr Thr Gln Glu Ser Ala Tyr Tyr Glu Pro Pro Trp Asn 
385                 390                 395                 400 


Tyr Ser Asp Phe Gly Val Ala Ile Met Asn Val Pro Thr Leu Ile Gly 
                405                 410                 415     


Ala Val Ile Gly Cys Ile Cys Ala Gly Ile Val Ser Asp Tyr Phe Val 
            420                 425                 430         


Leu Trp Met Ala Arg His Asn Arg Gly Ile Leu Glu Ala Glu Phe Arg 
        435                 440                 445             


Leu Tyr Phe Ser Ile Ala Thr Ala Ile Ile Gly Pro Ala Gly Leu Leu 
    450                 455                 460                 


Met Phe Gly Ile Gly Thr Ala Arg Gln Trp Pro Trp Gln Ala Ile Tyr 
465                 470                 475                 480 


Val Gly Leu Gly Phe Val Gly Phe Ala Trp Gly Cys Ser Gly Asp Ile 
                485                 490                 495     


Ala Met Ala Tyr Leu Met Asp Cys Tyr Pro Asp Met Val Leu Glu Gly 
            500                 505                 510         


Met Val Cys Thr Ala Ile Ile Asn Asn Thr Ile Ser Cys Ile Phe Thr 
        515                 520                 525             


Phe Thr Cys Ser Asp Trp Leu Ala Ala Ser Gly Thr Glu Asn Thr Tyr 
    530                 535                 540                 


Ile Ala Leu Ala Val Ile Asn Phe Gly Ile Thr Ala Phe Ala Leu Pro 
545                 550                 555                 560 


Met Tyr Tyr Tyr Gly Lys Arg Ile Arg Leu Trp Thr Lys Arg Trp Tyr 
                565                 570                 575     


Leu Gln Ser Val Asn Leu Arg Asp Gly Val 
            580                 585     


<210>  36
<211>  563
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  36

Met Thr Lys Gln Gln Thr Ser Val Met Arg Asn Ala Ser Ile Ala Lys 
1               5                   10                  15      


Glu Glu Arg Glu Gly Ser Asp Asn Asn Asn Val Asp Arg Ser Ser Ser 
            20                  25                  30          


Asp Ala Ile Ser Asp Asn Asp Ala Glu Arg Ser Asn Ser His Ser Glu 
        35                  40                  45              


Ile Asp Asn Glu Ser Asn Phe Asp Met Val Pro Tyr Ser Arg Phe Ser 
    50                  55                  60                  


His Lys Gln Lys Met Leu Leu Val Val Gln Cys Ala Phe Thr Gly Phe 
65                  70                  75                  80  


Phe Ser Thr Val Ala Gly Ser Ile Tyr Tyr Pro Val Leu Thr Ile Ile 
                85                  90                  95      


Glu Arg Lys Phe Asn Ile Thr Glu Glu Leu Ala Asn Val Thr Ile Val 
            100                 105                 110         


Val Tyr Phe Ile Phe Gln Gly Val Ala Pro Ser Ile Met Gly Gly Leu 
        115                 120                 125             


Ala Asp Thr Phe Gly Arg Arg Pro Ile Val Leu Trp Ala Ile Leu Ala 
    130                 135                 140                 


Tyr Phe Cys Ala Cys Ile Gly Leu Ala Cys Ala His Asn Tyr Ala Gln 
145                 150                 155                 160 


Ile Leu Ala Leu Arg Cys Leu Gln Ala Ala Gly Ile Ser Pro Val Ile 
                165                 170                 175     


Ala Ile Asn Ser Gly Ile Met Gly Asp Val Thr Thr Lys Val Glu Arg 
            180                 185                 190         


Gly Gly Tyr Val Gly Leu Val Ala Gly Phe Gln Val Val Gly Thr Ala 
        195                 200                 205             


Phe Gly Ala Leu Ile Gly Ala Gly Leu Ser Ser Lys Trp Gly Trp Arg 
    210                 215                 220                 


Ala Ile Phe Trp Phe Leu Ala Ile Gly Ser Gly Ile Cys Leu Val Phe 
225                 230                 235                 240 


Ser Thr Leu Leu Met Pro Glu Thr Lys Arg Thr Leu Val Gly Asn Gly 
                245                 250                 255     


Ser Val Thr Pro Arg Ser Phe Leu Asn Arg Ser Leu Ile Leu His Val 
            260                 265                 270         


Gly Ser Val Lys Lys Thr Leu His Leu Asp Asp Pro Asp Pro Glu Thr 
        275                 280                 285             


Leu Glu Pro Arg Thr Ser Val Asp Phe Leu Ala Pro Leu Lys Ile Leu 
    290                 295                 300                 


His Ile Arg Glu Ile Asp Ile Leu Leu Ser Ile Ala Gly Leu Gln Phe 
305                 310                 315                 320 


Ser Thr Trp Thr Thr His Gln Thr Ala Leu Thr Ile Val Leu Ser Lys 
                325                 330                 335     


Lys Tyr Asn Leu Ser Val Ala Lys Ile Gly Leu Cys Phe Leu Pro Ala 
            340                 345                 350         


Gly Ile Ser Thr Leu Thr Ser Ile Ile Ser Ala Gly Arg Tyr Leu Asn 
        355                 360                 365             


Trp Ser Tyr Arg Thr Arg Lys Val Lys Tyr Asn Arg Trp Ile Lys Glu 
    370                 375                 380                 


Gln Glu Leu Gln Leu Met Glu Lys Tyr Lys Gly Asp Lys Asn Lys Val 
385                 390                 395                 400 


Ala Glu Leu Ile His Ser Asn Ser His Tyr Ala Phe Asn Leu Val Glu 
                405                 410                 415     


Ala Arg Leu His Pro Ala Phe Val Thr Leu Leu Leu Ser Ser Ile Gly 
            420                 425                 430         


Phe Thr Ala Phe Gly Trp Cys Ile Ser Val Lys Thr Pro Leu Ala Ala 
        435                 440                 445             


Val Leu Cys Thr Ser Ala Phe Ala Ser Leu Phe Ser Asn Cys Ile Leu 
    450                 455                 460                 


Thr Phe Ser Thr Thr Leu Ile Val Asp Leu Phe Pro Ser Lys Ala Ser 
465                 470                 475                 480 


Thr Ala Thr Gly Cys Leu Asn Leu Phe Arg Cys Leu Leu Ser Ala Ile 
                485                 490                 495     


Phe Ile Ala Ala Leu Thr Lys Met Val Glu Lys Met Arg Tyr Gly Gly 
            500                 505                 510         


Val Phe Thr Phe Leu Ser Ala Ile Thr Ser Ser Ser Ser Leu Leu Leu 
        515                 520                 525             


Phe Tyr Leu Leu Lys Asn Gly Lys Gln Leu Ser Phe Asp Arg Ile Arg 
    530                 535                 540                 


Ala Asn Asp Lys Ser Ala Gly Arg Ser Val Gly Lys Asn Ser Glu Lys 
545                 550                 555                 560 


Val Ser Thr 
            


<210>  37
<211>  689
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  37

Met Gln Ala Gln Gly Ser Gln Ser Asn Val Gly Ser Leu Arg Ser Asn 
1               5                   10                  15      


Cys Ser Asp Asn Ser Leu Pro Asn Asn His Val Met Met His Cys Asp 
            20                  25                  30          


Glu Ser Ser Gly Ser Pro His Ser Glu His Asn Asp Tyr Ser Tyr Glu 
        35                  40                  45              


Lys Thr Asn Leu Glu Ser Thr Ala Ser Asn Ser Arg Glu His Arg Asp 
    50                  55                  60                  


Asn Gln Leu Ser Arg Leu Lys Ser Glu Glu Tyr Val Val Pro Lys Asn 
65                  70                  75                  80  


Gln Arg Arg Gly Leu Leu Pro Gln Leu Ala Ile Ile Pro Glu Phe Lys 
                85                  90                  95      


Asp Ala Arg Asp Tyr Pro Pro Met Met Lys Lys Met Ile Val Phe Leu 
            100                 105                 110         


Ile Ala Phe Ser Ser Met Met Gly Pro Met Gly Thr Ser Ile Ile Phe 
        115                 120                 125             


Pro Ala Ile Asn Ser Ile Thr Thr Glu Phe Lys Thr Ser Val Ile Met 
    130                 135                 140                 


Val Asn Val Ser Ile Gly Val Tyr Leu Leu Ser Leu Gly Val Phe Pro 
145                 150                 155                 160 


Leu Trp Trp Ser Ser Leu Ser Glu Leu Glu Gly Arg Arg Thr Thr Tyr 
                165                 170                 175     


Ile Thr Ser Phe Ala Leu Leu Phe Ala Phe Asn Ile Gly Ser Ala Leu 
            180                 185                 190         


Ala Pro Asp Ile Asn Ser Phe Ile Ala Leu Arg Met Leu Cys Gly Ala 
        195                 200                 205             


Ala Ser Ala Ser Val Gln Ser Val Gly Ala Gly Thr Val Ala Asp Leu 
    210                 215                 220                 


Tyr Ile Ser Glu Asp Arg Gly Lys Asn Leu Ser Tyr Tyr Tyr Leu Gly 
225                 230                 235                 240 


Pro Leu Leu Ala Pro Leu Leu Ser Pro Ile Phe Gly Ser Leu Leu Val 
                245                 250                 255     


Asn Arg Trp Pro Trp Arg Ser Thr Gln Trp Phe Met Val Ile Leu Ser 
            260                 265                 270         


Gly Cys Asn Val Ile Leu Leu Thr Val Leu Leu Pro Glu Thr Leu Arg 
        275                 280                 285             


Lys Gln Asp Ser Lys Gly Ala Ile Ala Gln Ile Leu Ala Glu Arg Arg 
    290                 295                 300                 


Ile Gln Val Asp Asn Asn Glu Arg Gly Glu Ile Gln Glu Asp Tyr Gln 
305                 310                 315                 320 


Arg Gly Glu Asp Glu Thr Asp Arg Ile Glu Asn Gln Val Ala Thr Leu 
                325                 330                 335     


Ser Thr Glu Lys His Asn Tyr Val Gly Glu Val Arg Asp Gln Asp Ser 
            340                 345                 350         


Leu Asp Leu Glu Ser His Ser Ser Pro Asn Thr Tyr Asp Gly Arg Ala 
        355                 360                 365             


Gly Glu Thr Gln Leu Gln Arg Ile Tyr Thr Glu Ala Ser Arg Ser Leu 
    370                 375                 380                 


Tyr Glu Tyr Gln Leu Asp Asp Ser Gly Ile Asp Ala Thr Thr Ala Gln 
385                 390                 395                 400 


Val Thr Arg Ile Arg Ser Thr Asp Pro Lys Leu Ala Arg Ser Ile Arg 
                405                 410                 415     


Glu Asn Ser Leu Arg Lys Leu Gln Thr Asn Leu Glu Glu Gln Val Lys 
            420                 425                 430         


Lys Val Leu Ser Ser Asn Gly Gly Glu Ile Ala Pro Lys Gln Val Ser 
        435                 440                 445             


Ala Val Arg Lys Val Trp Asp Thr Phe Phe Val Tyr Phe Ile Lys Pro 
    450                 455                 460                 


Leu Lys Ser Leu His Phe Leu Glu Tyr Pro Pro Val Ala Leu Ala Ile 
465                 470                 475                 480 


Thr Phe Ser Ala Ile Ser Phe Ser Thr Val Tyr Phe Val Asn Met Thr 
                485                 490                 495     


Val Glu Tyr Lys Tyr Ser Arg Pro Pro Tyr Asn Phe Lys Pro Leu Tyr 
            500                 505                 510         


Ile Gly Leu Leu Tyr Ile Pro Asn Ser Val Thr Tyr Phe Phe Ala Ser 
        515                 520                 525             


Ile Tyr Gly Gly Arg Trp Val Asp Met Leu Leu Lys Arg Tyr Lys Glu 
    530                 535                 540                 


Lys Tyr Gly Ile Leu Ala Pro Glu Ala Arg Ile Ser Trp Asn Val Val 
545                 550                 555                 560 


Thr Ser Val Ile Ser Phe Pro Ile Ala Leu Leu Ile Phe Gly Trp Cys 
                565                 570                 575     


Leu Asp Lys Lys Cys His Trp Val Thr Pro Leu Ile Gly Thr Ala Leu 
            580                 585                 590         


Phe Gly Tyr Ala Ala Met Met Thr Ile Gly Ala Thr Leu Ser Tyr Leu 
        595                 600                 605             


Val Asp Ser Leu Pro Gly Lys Gly Ala Thr Gly Val Ala Leu Asn Asn 
    610                 615                 620                 


Leu Ile Arg Gln Ile Leu Ala Ala Thr Ala Val Phe Val Thr Thr Pro 
625                 630                 635                 640 


Met Leu Asn Gly Met Gly Thr Gly Trp Ala Phe Thr Met Leu Ala Phe 
                645                 650                 655     


Ile Val Leu Gly Ala Ser Ser Val Leu Ile Ile Leu Lys Lys His Gly 
            660                 665                 670         


Asp Tyr Trp Arg Glu Asn Tyr Asp Leu Gln Lys Leu Tyr Asp Lys Ile 
        675                 680                 685             


Asp 
    


<210>  38
<211>  593
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  38

Met Tyr Ser Ile Val Lys Glu Ile Ile Val Asp Pro Tyr Lys Arg Leu 
1               5                   10                  15      


Lys Trp Gly Phe Ile Pro Val Lys Arg Gln Val Glu Asp Leu Pro Asp 
            20                  25                  30          


Asp Leu Asn Ser Thr Glu Ile Val Thr Ile Ser Asn Ser Ile Gln Ser 
        35                  40                  45              


His Glu Thr Ala Glu Asn Phe Ile Thr Thr Thr Ser Glu Lys Asp Gln 
    50                  55                  60                  


Leu His Phe Glu Thr Ser Ser Tyr Ser Glu His Lys Asp Asn Val Asn 
65                  70                  75                  80  


Val Thr Arg Ser Tyr Glu Tyr Arg Asp Glu Ala Asp Arg Pro Trp Trp 
                85                  90                  95      


Arg Phe Phe Asp Glu Gln Glu Tyr Arg Ile Asn Glu Lys Glu Arg Ser 
            100                 105                 110         


His Asn Lys Trp Tyr Ser Trp Phe Lys Gln Gly Thr Ser Phe Lys Glu 
        115                 120                 125             


Lys Lys Leu Leu Ile Lys Leu Asp Val Leu Leu Ala Phe Tyr Ser Cys 
    130                 135                 140                 


Ile Ala Tyr Trp Val Lys Tyr Leu Asp Thr Val Asn Ile Asn Asn Ala 
145                 150                 155                 160 


Tyr Val Ser Gly Met Lys Glu Asp Leu Gly Phe Gln Gly Asn Asp Leu 
                165                 170                 175     


Val His Thr Gln Val Met Tyr Thr Val Gly Asn Ile Ile Phe Gln Leu 
            180                 185                 190         


Pro Phe Leu Ile Tyr Leu Asn Lys Leu Pro Leu Asn Tyr Val Leu Pro 
        195                 200                 205             


Ser Leu Asp Leu Cys Trp Ser Leu Leu Thr Val Gly Ala Ala Tyr Val 
    210                 215                 220                 


Asn Ser Val Pro His Leu Lys Ala Ile Arg Phe Phe Ile Gly Ala Phe 
225                 230                 235                 240 


Glu Ala Pro Ser Tyr Leu Ala Tyr Gln Tyr Leu Phe Gly Ser Phe Tyr 
                245                 250                 255     


Lys His Asp Glu Met Val Arg Arg Ser Ala Phe Tyr Tyr Leu Gly Gln 
            260                 265                 270         


Tyr Ile Gly Ile Leu Ser Ala Gly Gly Ile Gln Ser Ala Val Tyr Ser 
        275                 280                 285             


Ser Leu Asn Gly Val Asn Gly Leu Glu Gly Trp Arg Trp Asn Phe Ile 
    290                 295                 300                 


Ile Asp Ala Ile Val Ser Val Val Val Gly Leu Ile Gly Phe Tyr Ser 
305                 310                 315                 320 


Leu Pro Gly Asp Pro Tyr Asn Cys Tyr Ser Ile Phe Leu Thr Asp Asp 
                325                 330                 335     


Glu Ile Arg Leu Ala Arg Lys Arg Leu Lys Glu Asn Gln Thr Gly Lys 
            340                 345                 350         


Ser Asp Phe Glu Thr Lys Val Phe Asp Ile Lys Leu Trp Lys Thr Ile 
        355                 360                 365             


Phe Ser Asp Trp Lys Ile Tyr Ile Leu Thr Leu Trp Asn Ile Phe Cys 
    370                 375                 380                 


Trp Asn Asp Ser Asn Val Ser Ser Gly Ala Tyr Leu Leu Trp Leu Lys 
385                 390                 395                 400 


Ser Leu Lys Arg Tyr Ser Ile Pro Lys Leu Asn Gln Leu Ser Met Ile 
                405                 410                 415     


Thr Pro Gly Leu Gly Met Val Tyr Leu Met Leu Thr Gly Ile Ile Ala 
            420                 425                 430         


Asp Lys Leu His Ser Arg Trp Phe Ala Ile Ile Phe Thr Gln Val Phe 
        435                 440                 445             


Asn Ile Ile Gly Asn Ser Ile Leu Ala Ala Trp Asp Val Ala Glu Gly 
    450                 455                 460                 


Ala Lys Trp Phe Ala Phe Met Leu Gln Cys Phe Gly Trp Ala Met Ala 
465                 470                 475                 480 


Pro Val Leu Tyr Ser Trp Gln Asn Asp Ile Cys Arg Arg Asp Ala Gln 
                485                 490                 495     


Thr Arg Ala Ile Thr Leu Val Thr Met Asn Ile Met Ala Gln Ser Ser 
            500                 505                 510         


Thr Ala Trp Ile Ser Val Leu Val Trp Lys Thr Glu Glu Ala Pro Arg 
        515                 520                 525             


Tyr Leu Lys Gly Phe Thr Phe Thr Ala Cys Ser Ala Phe Cys Leu Ser 
    530                 535                 540                 


Ile Trp Thr Phe Val Val Leu Tyr Phe Tyr Lys Arg Asp Glu Arg Asn 
545                 550                 555                 560 


Asn Ala Lys Lys Asn Gly Ile Val Leu Tyr Asn Ser Lys His Gly Val 
                565                 570                 575     


Glu Lys Pro Thr Ser Lys Asp Val Glu Thr Leu Ser Val Ser Asp Glu 
            580                 585                 590         


Lys 
    


<210>  39
<211>  543
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  39

Met Lys Ser Thr Leu Ser Leu Thr Leu Cys Val Ile Ser Leu Leu Leu 
1               5                   10                  15      


Thr Leu Phe Leu Ala Ala Leu Asp Ile Val Ile Val Val Thr Leu Tyr 
            20                  25                  30          


Asp Thr Ile Gly Ile Lys Phe His Asp Phe Gly Asn Ile Gly Trp Leu 
        35                  40                  45              


Val Thr Gly Tyr Ala Leu Ser Asn Ala Val Phe Met Leu Leu Trp Gly 
    50                  55                  60                  


Arg Leu Ala Glu Ile Leu Gly Thr Lys Glu Cys Leu Met Ile Ser Val 
65                  70                  75                  80  


Ile Val Phe Glu Ile Gly Ser Leu Ile Ser Ala Leu Ser Asn Ser Met 
                85                  90                  95      


Ala Thr Leu Ile Ser Gly Arg Val Val Ala Gly Phe Gly Gly Ser Gly 
            100                 105                 110         


Ile Glu Ser Leu Ala Phe Val Val Gly Thr Ser Ile Val Arg Glu Asn 
        115                 120                 125             


His Arg Gly Ile Met Ile Thr Ala Leu Ala Ile Ser Tyr Val Ile Ala 
    130                 135                 140                 


Glu Gly Val Gly Pro Phe Ile Gly Gly Ala Phe Asn Glu His Leu Ser 
145                 150                 155                 160 


Trp Arg Trp Cys Phe Tyr Ile Asn Leu Pro Ile Gly Ala Phe Ala Phe 
                165                 170                 175     


Ile Ile Leu Ala Phe Cys Asn Thr Ser Gly Glu Pro His Gln Lys Met 
            180                 185                 190         


Trp Leu Pro Ser Lys Ile Lys Lys Ile Met Asn Tyr Asp Tyr Gly Glu 
        195                 200                 205             


Leu Leu Lys Ala Ser Phe Trp Lys Asn Thr Phe Glu Val Leu Val Phe 
    210                 215                 220                 


Lys Leu Asp Met Val Gly Ile Ile Leu Ser Ser Ala Gly Phe Thr Leu 
225                 230                 235                 240 


Leu Met Leu Gly Leu Ser Phe Gly Gly Asn Asn Phe Pro Trp Asn Ser 
                245                 250                 255     


Gly Ile Ile Ile Cys Phe Phe Thr Val Gly Pro Ile Leu Leu Leu Leu 
            260                 265                 270         


Phe Cys Ala Tyr Asp Phe His Phe Leu Ser Leu Ser Gly Leu His Tyr 
        275                 280                 285             


Asp Asn Lys Arg Ile Lys Pro Leu Leu Thr Trp Asn Ile Ala Ser Asn 
    290                 295                 300                 


Cys Gly Ile Phe Thr Ser Ser Ile Thr Gly Phe Leu Ser Cys Phe Ala 
305                 310                 315                 320 


Tyr Glu Leu Gln Ser Ala Tyr Leu Val Gln Leu Tyr Gln Leu Val Phe 
                325                 330                 335     


Lys Lys Lys Pro Thr Leu Ala Ser Ile His Leu Trp Glu Leu Ser Ile 
            340                 345                 350         


Pro Ala Met Ile Ala Thr Met Ala Ile Ala Tyr Leu Asn Ser Lys Tyr 
        355                 360                 365             


Gly Ile Ile Lys Pro Ala Ile Val Phe Gly Val Leu Cys Gly Ile Val 
    370                 375                 380                 


Gly Ser Gly Leu Phe Thr Leu Ile Asn Gly Glu Leu Ser Gln Ser Ile 
385                 390                 395                 400 


Gly Tyr Ser Ile Leu Pro Gly Ile Ala Phe Gly Ser Ile Phe Gln Ala 
                405                 410                 415     


Thr Leu Leu Ser Ser Gln Val Gln Ile Thr Ser Asp Asp Pro Asp Phe 
            420                 425                 430         


Gln Asn Lys Phe Ile Glu Val Thr Ala Phe Asn Ser Phe Ala Lys Ser 
        435                 440                 445             


Leu Gly Phe Ala Phe Gly Gly Asn Met Gly Ala Met Ile Phe Thr Ala 
    450                 455                 460                 


Ser Leu Lys Asn Gln Met Arg Ser Ser Gln Leu Asn Ile Pro Gln Phe 
465                 470                 475                 480 


Thr Ser Val Glu Thr Leu Leu Ala Tyr Ser Thr Glu His Tyr Asp Gly 
                485                 490                 495     


Pro Gln Ser Ser Leu Ser Lys Phe Ile Asn Thr Ala Ile His Asp Val 
            500                 505                 510         


Phe Tyr Cys Ala Leu Gly Cys Tyr Ala Leu Ser Phe Phe Phe Gly Ile 
        515                 520                 525             


Phe Thr Ser Ser Lys Lys Thr Thr Ile Ser Ala Lys Lys Gln Gln 
    530                 535                 540             


<210>  40
<211>  598
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  40

Met Ser Phe Gly Ser Lys Val Ser Arg Ala Leu Arg Phe Leu Glu Ile 
1               5                   10                  15      


Pro Val Lys Asp Arg Ala Ser Val Ser Phe Leu Lys Asn Pro Asp Leu 
            20                  25                  30          


Gln Pro Ile Lys Ser Ala Asn Gln Thr Trp Gly Phe Trp Ser Asn Phe 
        35                  40                  45              


Ala Tyr Trp Gly Val Met Ser Phe Ser Val Gly Thr Trp Met Ser Ala 
    50                  55                  60                  


Ser Ser Ala Leu Gly Val Gly Leu Ser Tyr Pro Glu Thr Ile Gly Thr 
65                  70                  75                  80  


Phe Ile Val Gly Asp Val Leu Thr Ile Ile Phe Thr Leu Ala Asn Ser 
                85                  90                  95      


Cys Pro Gly Tyr Asp Trp Lys Val Gly Phe Thr Leu Ala Gln Arg Phe 
            100                 105                 110         


Val Phe Gly Ile Tyr Gly Ser Ala Phe Gly Ile Ile Ile Arg Ile Leu 
        115                 120                 125             


Met Ser Ile Val Asn Tyr Gly Ser Asn Ala Trp Val Gly Gly Leu Cys 
    130                 135                 140                 


Ile Asn Met Ile Leu Asp Ser Trp Ser His His Tyr Leu His Leu Pro 
145                 150                 155                 160 


Asn Thr Leu Ser Ser Lys Val Ala Met Thr Thr Lys Glu Leu Ile Gly 
                165                 170                 175     


Phe Ile Ile Phe His Val Leu Thr Ala Phe Cys Tyr Leu Met Lys Pro 
            180                 185                 190         


Tyr His Met Asn Tyr Ile Leu Ile Trp Ser Cys Val Ala Thr Phe Phe 
        195                 200                 205             


Ser Met Leu Gly Met Val Ile Tyr Leu Ala Lys Gln Ala His Gly Val 
    210                 215                 220                 


Gly Glu Leu Phe Thr Ser Thr Lys Ser Thr Ala Thr Gly Ser Thr Lys 
225                 230                 235                 240 


Ala Trp Ala Trp Val Tyr Met Ile Ser Tyr Trp Phe Gly Ser Val Ser 
                245                 250                 255     


Pro Gly Ser Thr Asn Gln Ser Asp Tyr Ser Arg Phe Gly Ser Ser Asn 
            260                 265                 270         


Trp Ala Ile Trp Ala Gly Thr Ile Cys Ala Leu Leu Ile Pro Thr Thr 
        275                 280                 285             


Leu Ile Pro Val Phe Gly Val Ile Gly Ala Ser Thr Cys Asp Lys Leu 
    290                 295                 300                 


Tyr Gly Glu Gln Tyr Trp Met Pro Met Asp Ile Phe Asn His Trp Leu 
305                 310                 315                 320 


Thr Thr Asn Tyr Ser Ala Gly Ala Arg Ala Gly Ala Phe Phe Cys Gly 
                325                 330                 335     


Leu Ser Phe Val Leu Ser Gln Met Ser Tyr Thr Ile Ser Asn Cys Gly 
            340                 345                 350         


Phe Ala Ser Gly Met Asp Leu Ala Gly Leu Leu Pro Lys Tyr Val Asp 
        355                 360                 365             


Ile Lys Arg Gly Ala Leu Phe Ala Ala Cys Val Ser Trp Ala Cys Leu 
    370                 375                 380                 


Pro Trp Asn Phe Tyr Asn Ser Ser Ser Thr Phe Leu Thr Val Met Ser 
385                 390                 395                 400 


Ser Phe Gly Val Val Met Thr Pro Ile Ile Ser Val Met Ile Cys Asp 
                405                 410                 415     


Asn Phe Leu Ile Arg Lys Arg Gln Tyr Ser Ile Thr Asn Ala Phe Ile 
            420                 425                 430         


Leu Lys Gly Glu Tyr Tyr Phe Thr Lys Gly Val Asn Trp Arg Ala Ile 
        435                 440                 445             


Val Ala Trp Val Cys Gly Met Thr Pro Gly Leu Pro Gly Ile Ala Trp 
    450                 455                 460                 


Glu Val Asn Asn Asp Tyr Phe His Asn Thr Gly Ile Val Asn Phe Phe 
465                 470                 475                 480 


Tyr Gly Asp Ser Phe Phe Ser Phe Leu Ile Ser Phe Phe Val Tyr Trp 
                485                 490                 495     


Gly Leu Cys Leu Leu Phe Pro Phe Lys Ile Thr Val Lys His Asp Asp 
            500                 505                 510         


Lys Asp Tyr Tyr Gly Ala Phe Thr Asp Glu Glu Ala Arg Lys Lys Gly 
        515                 520                 525             


Met Val Pro Tyr Ser Glu Ile Ser Glu Glu Glu Ile Arg Ala Tyr Thr 
    530                 535                 540                 


Leu Gly Glu Gly Tyr Thr Thr Gly His Glu Tyr Arg Pro Glu Gly Ser 
545                 550                 555                 560 


Asp Asp Glu Ile Pro Glu Leu Val Lys Thr Ser Ser Glu Asn Thr Asn 
                565                 570                 575     


Glu Phe Glu Ile Val His His Lys Asn Asn Glu Lys Gln Ser Ser Thr 
            580                 585                 590         


Ala Ser Glu Lys Ala Ala 
        595             


<210>  41
<211>  582
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  41

Met Glu Glu Thr Lys Tyr Ser Ser Gln Gln Glu Ile Glu Gly Ala Cys 
1               5                   10                  15      


Gly Ser Asp Ala Ser Leu Asn Ala Arg Gly Ser Asn Asp Ser Pro Met 
            20                  25                  30          


Gly Leu Ser Leu Tyr Leu Cys Leu Ala Ser Leu Thr Leu Val Leu Phe 
        35                  40                  45              


Ile Thr Ala Leu Asp Ile Leu Ile Val Gly Thr Ile Ile Asp Val Val 
    50                  55                  60                  


Ala Glu Gln Phe Gly Asn Tyr Ser Lys Thr Gly Trp Leu Val Thr Gly 
65                  70                  75                  80  


Tyr Ser Leu Pro Asn Ala Ile Leu Ser Leu Ile Trp Gly Arg Phe Ala 
                85                  90                  95      


Ser Ile Ile Gly Phe Gln His Ser Leu Ile Leu Ala Ile Leu Ile Phe 
            100                 105                 110         


Glu Ala Gly Ser Leu Ile Ala Ala Leu Ala Ser Ser Met Asn Met Leu 
        115                 120                 125             


Ile Phe Gly Arg Val Val Ala Gly Val Gly Gly Ser Gly Leu Gln Thr 
    130                 135                 140                 


Leu Cys Phe Val Ile Gly Cys Thr Met Val Gly Glu Arg Ser Arg Pro 
145                 150                 155                 160 


Leu Val Ile Ser Ile Leu Ser Cys Ala Phe Ala Val Ala Ala Ile Val 
                165                 170                 175     


Gly Pro Ile Ile Gly Gly Ala Phe Thr Thr His Val Thr Trp Arg Trp 
            180                 185                 190         


Cys Phe Tyr Ile Asn Leu Pro Ile Gly Gly Leu Ala Ile Ile Met Phe 
        195                 200                 205             


Leu Leu Thr Tyr Lys Ala Glu Asn Lys Gly Ile Leu Gln Gln Ile Lys 
    210                 215                 220                 


Asp Ala Ile Gly Thr Ile Ser Ser Phe Thr Phe Ser Lys Phe Arg His 
225                 230                 235                 240 


Gln Val Asn Phe Lys Arg Leu Met Asn Gly Ile Ile Phe Lys Phe Asp 
                245                 250                 255     


Phe Phe Gly Phe Ala Leu Cys Ser Ala Gly Leu Val Leu Phe Leu Leu 
            260                 265                 270         


Gly Leu Thr Phe Gly Gly Asn Lys Tyr Ser Trp Asn Ser Gly Gln Val 
        275                 280                 285             


Ile Thr Tyr Leu Val Leu Gly Val Leu Leu Phe Ile Phe Ser Leu Val 
    290                 295                 300                 


Tyr Asp Phe Phe Leu Phe Asp Lys Phe Asn Pro Glu Pro Asp Asn Ile 
305                 310                 315                 320 


Ser Tyr Arg Pro Leu Leu Leu Arg Arg Leu Val Ala Lys Pro Ala Ile 
                325                 330                 335     


Ile Ile Val Asn Met Val Thr Phe Leu Leu Cys Thr Gly Tyr Asn Gly 
            340                 345                 350         


Gln Met Ile Tyr Ser Val Gln Phe Phe Gln Leu Ile Phe Ala Ser Ser 
        355                 360                 365             


Ala Trp Lys Ala Gly Leu His Leu Ile Pro Ile Val Ile Thr Asn Val 
    370                 375                 380                 


Ile Ala Ala Ile Ala Ser Gly Val Ile Thr Lys Lys Leu Gly Leu Val 
385                 390                 395                 400 


Lys Pro Leu Leu Ile Phe Gly Gly Val Leu Gly Val Ile Gly Ala Gly 
                405                 410                 415     


Leu Met Thr Leu Met Thr Asn Thr Ser Thr Lys Ser Thr Gln Ile Gly 
            420                 425                 430         


Val Leu Leu Leu Pro Gly Phe Ser Leu Gly Phe Ala Leu Gln Ala Ser 
        435                 440                 445             


Leu Met Ser Ala Gln Leu Gln Ile Thr Lys Asp Arg Pro Glu Ala Ala 
    450                 455                 460                 


Met Asp Phe Ile Glu Val Thr Ala Phe Asn Thr Phe Met Lys Ser Leu 
465                 470                 475                 480 


Gly Thr Thr Leu Gly Gly Val Leu Ser Thr Thr Val Phe Ser Ala Ser 
                485                 490                 495     


Phe His Asn Lys Val Ser Arg Ala His Leu Glu Pro Tyr Glu Gly Lys 
            500                 505                 510         


Thr Val Asp Asp Met Ile Leu Tyr Arg Leu Gln Asn Tyr Asp Gly Ser 
        515                 520                 525             


His Ser Thr Ile Gly Asn Ile Leu Ser Asp Ser Ile Lys Asn Val Phe 
    530                 535                 540                 


Trp Met Asp Leu Gly Phe Tyr Ala Leu Gly Phe Leu Phe Cys Ser Phe 
545                 550                 555                 560 


Ser Ser Asn Lys Lys Leu Ile Ile Pro Lys Lys Asp Asp Thr Pro Glu 
                565                 570                 575     


Asp Asn Leu Glu Asp Lys 
            580         


