                         SEQUENCE LISTING

<110>  PORTO CONTE RICERCHE S.r.l.
 
<120>  BIOMARKERS

<130>  10441PTWO

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gly Gly Arg Ala Pro Ala Val Leu Leu Gly Gly Val Ala Ser 
1               5                   10                  15      


Leu Leu Leu Ser Phe Val Trp Met Pro Ala Leu Leu Pro Val Ala Ser 
            20                  25                  30          


Arg Leu Leu Leu Leu Pro Arg Val Leu Leu Thr Met Ala Ser Gly Ser 
        35                  40                  45              


Pro Pro Thr Gln Pro Ser Pro Ala Ser Asp Ser Gly Ser Gly Tyr Val 
    50                  55                  60                  


Pro Gly Ser Val Ser Ala Ala Phe Val Thr Cys Pro Asn Glu Lys Val 
65                  70                  75                  80  


Ala Lys Glu Ile Ala Arg Ala Val Val Glu Lys Arg Leu Ala Ala Cys 
                85                  90                  95      


Val Asn Leu Ile Pro Gln Ile Thr Ser Ile Tyr Glu Trp Lys Gly Lys 
            100                 105                 110         


Ile Glu Glu Asp Ser Glu Val Leu Met Met Ile Lys Thr Gln Ser Ser 
        115                 120                 125             


Leu Val Pro Ala Leu Thr Asp Phe Val Arg Ser Val His Pro Tyr Glu 
    130                 135                 140                 


Val Ala Glu Val Ile Ala Leu Pro Val Glu Gln Gly Asn Phe Pro Tyr 
145                 150                 155                 160 


Leu Gln Trp Val Arg Gln Val Thr Glu Ser Val Ser Asp Ser Ile Thr 
                165                 170                 175     


Val Leu Pro 
            


<210>  2
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210>  3
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  4
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  5
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp 
1               5                   10                  15      


Ser Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser 
            20                  25                  30          


Tyr Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala 
        35                  40                  45              


Leu Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg 
    50                  55                  60                  


Glu His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg 
65                  70                  75                  80  


Ile Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser 
                85                  90                  95      


Gly Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn 
            100                 105                 110         


Gln Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro 
        115                 120                 125             


His Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys 
    130                 135                 140                 


Ala Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly 
145                 150                 155                 160 


Ala Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu 
                165                 170                 175     


Gly Asp Ser Asp Asn Glu Ser 
            180             


<210>  6
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  7
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Thr Gly Thr Tyr His Gly Asp Ser Asp Leu Gln Leu Asp Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Thr Gly Gly Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Pro 
65                  70                  75                  80  


Phe Gly Gln Ile Phe Arg Pro Asp Asn Phe Val Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Ala Glu Ser Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Ile Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Val His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Cys Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ser Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Val Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Ala Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Asn Val Gln Asn Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Thr Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ala Val Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Glu Asp Phe Gly Glu Glu Ala Glu Glu Glu Ala 
        435                 440                 


<210>  8
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Asn Val Thr Asn Lys Thr Asp Pro Arg Ser Met Asn Ser 
1               5                   10                  15      


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30          


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys Ser Val 
        35                  40                  45              


His Lys Gly Phe Ala Phe Val Gln Tyr Val Asn Glu Arg Asn Ala Arg 
    50                  55                  60                  


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Gly Gln Val Leu 
65                  70                  75                  80  


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Lys Ala Gly 
                85                  90                  95      


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Val Thr Glu His Pro 
            100                 105                 110         


Ser Pro Ser Pro Leu Leu Ser Ser Ser Phe Asp Leu Asp Tyr Asp Phe 
        115                 120                 125             


Gln Arg Asp Tyr Tyr Asp Arg Met Tyr Ser Tyr Pro Ala Arg Val Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ile Ala Arg Ala Val Val Pro Ser Lys Arg Gln Arg 
145                 150                 155                 160 


Val Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe Asn Ser Lys 
                165                 170                 175     


Ser Gly Gln Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys Gly Asp Asp 
            180                 185                 190         


Leu Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp 
        195                 200                 205             


Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln Ser Lys Gln 
    210                 215                 220                 


Ala Val Glu Met Lys Asn Asp Lys Ser Glu Glu Glu Gln Ser Ser Ser 
225                 230                 235                 240 


Ser Val Lys Lys Asp Glu Thr Asn Val Lys Met Glu Ser Glu Gly Gly 
                245                 250                 255     


Ala Asp Asp Ser Ala Glu Glu Gly Asp Leu Leu Asp Asp Asp Asp Asn 
            260                 265                 270         


Glu Asp Arg Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp Asp Glu Lys 
        275                 280                 285             


Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Ala Asn Gly Glu Asp 
    290                 295                 300                 


Asp Ser 
305     


<210>  9
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Glu Ser His Leu Leu Gln Trp Leu Leu Leu Leu Leu Pro Thr 
1               5                   10                  15      


Leu Cys Gly Pro Gly Thr Ala Ala Trp Thr Thr Ser Ser Leu Ala Cys 
            20                  25                  30          


Ala Gln Gly Pro Glu Phe Trp Cys Gln Ser Leu Glu Gln Ala Leu Gln 
        35                  40                  45              


Cys Arg Ala Leu Gly His Cys Leu Gln Glu Val Trp Gly His Val Gly 
    50                  55                  60                  


Ala Asp Asp Leu Cys Gln Glu Cys Glu Asp Ile Val His Ile Leu Asn 
65                  70                  75                  80  


Lys Met Ala Lys Glu Ala Ile Phe Gln Asp Thr Met Arg Lys Phe Leu 
                85                  90                  95      


Glu Gln Glu Cys Asn Val Leu Pro Leu Lys Leu Leu Met Pro Gln Cys 
            100                 105                 110         


Asn Gln Val Leu Asp Asp Tyr Phe Pro Leu Val Ile Asp Tyr Phe Gln 
        115                 120                 125             


Asn Gln Thr Asp Ser Asn Gly Ile Cys Met His Leu Gly Leu Cys Lys 
    130                 135                 140                 


Ser Arg Gln Pro Glu Pro Glu Gln Glu Pro Gly Met Ser Asp Pro Leu 
145                 150                 155                 160 


Pro Lys Pro Leu Arg Asp Pro Leu Pro Asp Pro Leu Leu Asp Lys Leu 
                165                 170                 175     


Val Leu Pro Val Leu Pro Gly Ala Leu Gln Ala Arg Pro Gly Pro His 
            180                 185                 190         


Thr Gln Asp Leu Ser Glu Gln Gln Phe Pro Ile Pro Leu Pro Tyr Cys 
        195                 200                 205             


Trp Leu Cys Arg Ala Leu Ile Lys Arg Ile Gln Ala Met Ile Pro Lys 
    210                 215                 220                 


Gly Ala Leu Ala Val Ala Val Ala Gln Val Cys Arg Val Val Pro Leu 
225                 230                 235                 240 


Val Ala Gly Gly Ile Cys Gln Cys Leu Ala Glu Arg Tyr Ser Val Ile 
                245                 250                 255     


Leu Leu Asp Thr Leu Leu Gly Arg Met Leu Pro Gln Leu Val Cys Arg 
            260                 265                 270         


Leu Val Leu Arg Cys Ser Met Asp Asp Ser Ala Gly Pro Arg Ser Pro 
        275                 280                 285             


Thr Gly Glu Trp Leu Pro Arg Asp Ser Glu Cys His Leu Cys Met Ser 
    290                 295                 300                 


Val Thr Thr Gln Ala Gly Asn Ser Ser Glu Gln Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Met Leu Gln Ala Cys Val Gly Ser Trp Leu Asp Arg Glu Lys Cys Lys 
                325                 330                 335     


Gln Phe Val Glu Gln His Thr Pro Gln Leu Leu Thr Leu Val Pro Arg 
            340                 345                 350         


Gly Trp Asp Ala His Thr Thr Cys Gln Ala Leu Gly Val Cys Gly Thr 
        355                 360                 365             


Met Ser Ser Pro Leu Gln Cys Ile His Ser Pro Asp Leu 
    370                 375                 380     


<210>  10
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ala Leu Leu Cys Ser Cys Leu Leu Leu Ala Ala Gly Ala Ser 
1               5                   10                  15      


Asp Ala Trp Thr Gly Glu Asp Ser Ala Glu Pro Asn Ser Asp Ser Ala 
            20                  25                  30          


Glu Trp Ile Arg Asp Met Tyr Ala Lys Val Thr Glu Ile Trp Gln Glu 
        35                  40                  45              


Val Met Gln Arg Arg Asp Asp Asp Gly Ala Leu His Ala Ala Cys Gln 
    50                  55                  60                  


Val Gln Pro Ser Ala Thr Leu Asp Ala Ala Gln Pro Arg Val Thr Gly 
65                  70                  75                  80  


Val Val Leu Phe Arg Gln Leu Ala Pro Arg Ala Lys Leu Asp Ala Phe 
                85                  90                  95      


Phe Ala Leu Glu Gly Phe Pro Thr Glu Pro Asn Ser Ser Ser Arg Ala 
            100                 105                 110         


Ile His Val His Gln Phe Gly Asp Leu Ser Gln Gly Cys Glu Ser Thr 
        115                 120                 125             


Gly Pro His Tyr Asn Pro Leu Ala Val Pro His Pro Gln His Pro Gly 
    130                 135                 140                 


Asp Phe Gly Asn Phe Ala Val Arg Asp Gly Ser Leu Trp Arg Tyr Arg 
145                 150                 155                 160 


Ala Gly Leu Ala Ala Ser Leu Ala Gly Pro His Ser Ile Val Gly Arg 
                165                 170                 175     


Ala Val Val Val His Ala Gly Glu Asp Asp Leu Gly Arg Gly Gly Asn 
            180                 185                 190         


Gln Ala Ser Val Glu Asn Gly Asn Ala Gly Arg Arg Leu Ala Cys Cys 
        195                 200                 205             


Val Val Gly Val Cys Gly Pro Gly Leu Trp Glu Arg Gln Ala Arg Glu 
    210                 215                 220                 


His Ser Glu Arg Lys Lys Arg Arg Arg Glu Ser Glu Cys Lys Ala Ala 
225                 230                 235                 240 


<210>  11
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gln Val Leu Arg Gly Thr Val Thr Asp Phe Pro Gly Phe Asp 
1               5                   10                  15      


Glu Arg Ala Asp Ala Glu Thr Leu Arg Lys Ala Met Lys Gly Leu Gly 
            20                  25                  30          


Thr Asp Glu Glu Ser Ile Leu Thr Leu Leu Thr Ser Arg Ser Asn Ala 
        35                  40                  45              


Gln Arg Gln Glu Ile Ser Ala Ala Phe Lys Thr Leu Phe Gly Arg Asp 
    50                  55                  60                  


Leu Leu Asp Asp Leu Lys Ser Glu Leu Thr Gly Lys Phe Glu Lys Leu 
65                  70                  75                  80  


Ile Val Ala Leu Met Lys Pro Ser Arg Leu Tyr Asp Ala Tyr Glu Leu 
                85                  90                  95      


Lys His Ala Leu Lys Gly Ala Gly Thr Asn Glu Lys Val Leu Thr Glu 
            100                 105                 110         


Ile Ile Ala Ser Arg Thr Pro Glu Glu Leu Arg Ala Ile Lys Gln Val 
        115                 120                 125             


Tyr Glu Glu Glu Tyr Gly Ser Ser Leu Glu Asp Asp Val Val Gly Asp 
    130                 135                 140                 


Thr Ser Gly Tyr Tyr Gln Arg Met Leu Val Val Leu Leu Gln Ala Asn 
145                 150                 155                 160 


Arg Asp Pro Asp Ala Gly Ile Asp Glu Ala Gln Val Glu Gln Asp Ala 
                165                 170                 175     


Gln Ala Leu Phe Gln Ala Gly Glu Leu Lys Trp Gly Thr Asp Glu Glu 
            180                 185                 190         


Lys Phe Ile Thr Ile Phe Gly Thr Arg Ser Val Ser His Leu Arg Lys 
        195                 200                 205             


Val Phe Asp Lys Tyr Met Thr Ile Ser Gly Phe Gln Ile Glu Glu Thr 
    210                 215                 220                 


Ile Asp Arg Glu Thr Ser Gly Asn Leu Glu Gln Leu Leu Leu Ala Val 
225                 230                 235                 240 


Val Lys Ser Ile Arg Ser Ile Pro Ala Tyr Leu Ala Glu Thr Leu Tyr 
                245                 250                 255     


Tyr Ala Met Lys Gly Ala Gly Thr Asp Asp His Thr Leu Ile Arg Val 
            260                 265                 270         


Met Val Ser Arg Ser Glu Ile Asp Leu Phe Asn Ile Arg Lys Glu Phe 
        275                 280                 285             


Arg Lys Asn Phe Ala Thr Ser Leu Tyr Ser Met Ile Lys Gly Asp Thr 
    290                 295                 300                 


Ser Gly Asp Tyr Lys Lys Ala Leu Leu Leu Leu Cys Gly Glu Asp Asp 
305                 310                 315                 320 


<210>  12
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210>  13
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Arg Ser Ala Ala Val Leu Ala Leu Leu Leu Cys Ala Gly Gln Val 
1               5                   10                  15      


Thr Ala Leu Pro Val Asn Ser Pro Met Asn Lys Gly Asp Thr Glu Val 
            20                  25                  30          


Met Lys Cys Ile Val Glu Val Ile Ser Asp Thr Leu Ser Lys Pro Ser 
        35                  40                  45              


Pro Met Pro Val Ser Gln Glu Cys Phe Glu Thr Leu Arg Gly Asp Glu 
    50                  55                  60                  


Arg Ile Leu Ser Ile Leu Arg His Gln Asn Leu Leu Lys Glu Leu Gln 
65                  70                  75                  80  


Asp Leu Ala Leu Gln Gly Ala Lys Glu Arg Ala His Gln Gln Lys Lys 
                85                  90                  95      


His Ser Gly Phe Glu Asp Glu Leu Ser Glu Val Leu Glu Asn Gln Ser 
            100                 105                 110         


Ser Gln Ala Glu Leu Lys Glu Ala Val Glu Glu Pro Ser Ser Lys Asp 
        115                 120                 125             


Val Met Glu Lys Arg Glu Asp Ser Lys Glu Ala Glu Lys Ser Gly Glu 
    130                 135                 140                 


Ala Thr Asp Gly Ala Arg Pro Gln Ala Leu Pro Glu Pro Met Gln Glu 
145                 150                 155                 160 


Ser Lys Ala Glu Gly Asn Asn Gln Ala Pro Gly Glu Glu Glu Glu Glu 
                165                 170                 175     


Glu Glu Glu Ala Thr Asn Thr His Pro Pro Ala Ser Leu Pro Ser Gln 
            180                 185                 190         


Lys Tyr Pro Gly Pro Gln Ala Glu Gly Asp Ser Glu Gly Leu Ser Gln 
        195                 200                 205             


Gly Leu Val Asp Arg Glu Lys Gly Leu Ser Ala Glu Pro Gly Trp Gln 
    210                 215                 220                 


Ala Lys Arg Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Glu Ala Val Pro Glu Glu Glu Gly Pro Thr Val Val Leu Asn Pro 
                245                 250                 255     


His Pro Ser Leu Gly Tyr Lys Glu Ile Arg Lys Gly Glu Ser Arg Ser 
            260                 265                 270         


Glu Ala Leu Ala Val Asp Gly Ala Gly Lys Pro Gly Ala Glu Glu Ala 
        275                 280                 285             


Gln Asp Pro Glu Gly Lys Gly Glu Gln Glu His Ser Gln Gln Lys Glu 
    290                 295                 300                 


Glu Glu Glu Glu Met Ala Val Val Pro Gln Gly Leu Phe Arg Gly Gly 
305                 310                 315                 320 


Lys Ser Gly Glu Leu Glu Gln Glu Glu Glu Arg Leu Ser Lys Glu Trp 
                325                 330                 335     


Glu Asp Ser Lys Arg Trp Ser Lys Met Asp Gln Leu Ala Lys Glu Leu 
            340                 345                 350         


Thr Ala Glu Lys Arg Leu Glu Gly Gln Glu Glu Glu Glu Asp Asn Arg 
        355                 360                 365             


Asp Ser Ser Met Lys Leu Ser Phe Arg Ala Arg Ala Tyr Gly Phe Arg 
    370                 375                 380                 


Gly Pro Gly Pro Gln Leu Arg Arg Gly Trp Arg Pro Ser Ser Arg Glu 
385                 390                 395                 400 


Asp Ser Leu Glu Ala Gly Leu Pro Leu Gln Val Arg Gly Tyr Pro Glu 
                405                 410                 415     


Glu Lys Lys Glu Glu Glu Gly Ser Ala Asn Arg Arg Pro Glu Asp Gln 
            420                 425                 430         


Glu Leu Glu Ser Leu Ser Ala Ile Glu Ala Glu Leu Glu Lys Val Ala 
        435                 440                 445             


His Gln Leu Gln Ala Leu Arg Arg Gly 
    450                 455         


<210>  14
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ser Glu Thr Ala Pro Ala Glu Thr Ala Thr Pro Ala Pro Val Glu 
1               5                   10                  15      


Lys Ser Pro Ala Lys Lys Lys Ala Thr Lys Lys Ala Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Lys Arg Lys Ala Thr Gly Pro Pro Val Ser Glu Leu Ile Thr 
        35                  40                  45              


Lys Ala Val Ala Ala Ser Lys Glu Arg Asn Gly Leu Ser Leu Ala Ala 
    50                  55                  60                  


Leu Lys Lys Ala Leu Ala Ala Gly Gly Tyr Asp Val Glu Lys Asn Asn 
65                  70                  75                  80  


Ser Arg Ile Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu 
                85                  90                  95      


Val Gln Thr Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys 
            100                 105                 110         


Lys Ala Ala Ser Gly Glu Ala Lys Pro Lys Ala Lys Lys Ala Gly Ala 
        115                 120                 125             


Ala Lys Ala Lys Lys Pro Ala Gly Ala Thr Pro Lys Lys Ala Lys Lys 
    130                 135                 140                 


Ala Ala Gly Ala Lys Lys Ala Val Lys Lys Thr Pro Lys Lys Ala Lys 
145                 150                 155                 160 


Lys Pro Ala Ala Ala Gly Val Lys Lys Val Ala Lys Ser Pro Lys Lys 
                165                 170                 175     


Ala Lys Ala Ala Ala Lys Pro Lys Lys Ala Thr Lys Ser Pro Ala Lys 
            180                 185                 190         


Pro Lys Ala Val Lys Pro Lys Ala Ala Lys Pro Lys Ala Ala Lys Pro 
        195                 200                 205             


Lys Ala Ala Lys Pro Lys Ala Ala Lys Ala Lys Lys Ala Ala Ala Lys 
    210                 215                 220                 


Lys Lys 
225     


<210>  15
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Glu Thr Ala Pro Ala Ala Pro Ala Ala Ala Pro Pro Ala Glu 
1               5                   10                  15      


Lys Ala Pro Val Lys Lys Lys Ala Ala Lys Lys Ala Gly Gly Thr Pro 
            20                  25                  30          


Arg Lys Ala Ser Gly Pro Pro Val Ser Glu Leu Ile Thr Lys Ala Val 
        35                  40                  45              


Ala Ala Ser Lys Glu Arg Ser Gly Val Ser Leu Ala Ala Leu Lys Lys 
    50                  55                  60                  


Ala Leu Ala Ala Ala Gly Tyr Asp Val Glu Lys Asn Asn Ser Arg Ile 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ser Leu Val Ser Lys Gly Thr Leu Val Gln Thr 
                85                  90                  95      


Lys Gly Thr Gly Ala Ser Gly Ser Phe Lys Leu Asn Lys Lys Ala Ala 
            100                 105                 110         


Ser Gly Glu Ala Lys Pro Lys Val Lys Lys Ala Gly Gly Thr Lys Pro 
        115                 120                 125             


Lys Lys Pro Val Gly Ala Ala Lys Lys Pro Lys Lys Ala Ala Gly Gly 
    130                 135                 140                 


Ala Thr Pro Lys Lys Ser Ala Lys Lys Thr Pro Lys Lys Ala Lys Lys 
145                 150                 155                 160 


Pro Ala Ala Ala Thr Val Thr Lys Lys Val Ala Lys Ser Pro Lys Lys 
                165                 170                 175     


Ala Lys Val Ala Lys Pro Lys Lys Ala Ala Lys Ser Ala Ala Lys Ala 
            180                 185                 190         


Val Lys Pro Lys Ala Ala Lys Pro Lys Val Val Lys Pro Lys Lys Ala 
        195                 200                 205             


Ala Pro Lys Lys Lys 
    210             


<210>  16
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Ser Ser Asp Ile Gln Val Lys Glu Leu Glu Lys Arg Ala Ser 
1               5                   10                  15      


Gly Gln Ala Phe Glu Leu Ile Leu Ser Pro Arg Ser Lys Glu Ser Val 
            20                  25                  30          


Pro Glu Phe Pro Leu Ser Pro Pro Lys Lys Lys Asp Leu Ser Leu Glu 
        35                  40                  45              


Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Ser His 
    50                  55                  60                  


Glu Ala Glu Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His Glu Lys 
65                  70                  75                  80  


Glu Val Leu Gln Lys Ala Ile Glu Glu Asn Asn Asn Phe Ser Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Leu Thr His Lys Met Glu Ala Asn Lys Glu Asn Arg 
            100                 105                 110         


Glu Ala Gln Met Ala Ala Lys Leu Glu Arg Leu Arg Glu Lys Asp Lys 
        115                 120                 125             


His Ile Glu Glu Val Arg Lys Asn Lys Glu Ser Lys Asp Pro Ala Asp 
    130                 135                 140                 


Glu Thr Glu Ala Asp 
145                 


<210>  17
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ala Tyr Lys Leu Val Leu Ile Arg His Gly Glu Ser Ala Trp 
1               5                   10                  15      


Asn Leu Glu Asn Arg Phe Ser Gly Trp Tyr Asp Ala Asp Leu Ser Pro 
            20                  25                  30          


Ala Gly His Glu Glu Ala Lys Arg Gly Gly Gln Ala Leu Arg Asp Ala 
        35                  40                  45              


Gly Tyr Glu Phe Asp Ile Cys Phe Thr Ser Val Gln Lys Arg Ala Ile 
    50                  55                  60                  


Arg Thr Leu Trp Thr Val Leu Asp Ala Ile Asp Gln Met Trp Leu Pro 
65                  70                  75                  80  


Val Val Arg Thr Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr 
                85                  90                  95      


Gly Leu Asn Lys Ala Glu Thr Ala Ala Lys His Gly Glu Ala Gln Val 
            100                 105                 110         


Lys Ile Trp Arg Arg Ser Tyr Asp Val Pro Pro Pro Pro Met Glu Pro 
        115                 120                 125             


Asp His Pro Phe Tyr Ser Asn Ile Ser Lys Asp Arg Arg Tyr Ala Asp 
    130                 135                 140                 


Leu Thr Glu Asp Gln Leu Pro Ser Cys Glu Ser Leu Lys Asp Thr Ile 
145                 150                 155                 160 


Ala Arg Ala Leu Pro Phe Trp Asn Glu Glu Ile Val Pro Gln Ile Lys 
                165                 170                 175     


Glu Gly Lys Arg Val Leu Ile Ala Ala His Gly Asn Ser Leu Arg Gly 
            180                 185                 190         


Ile Val Lys His Leu Glu Gly Leu Ser Glu Glu Ala Ile Met Glu Leu 
        195                 200                 205             


Asn Leu Pro Thr Gly Ile Pro Ile Val Tyr Glu Leu Asp Lys Asn Leu 
    210                 215                 220                 


Lys Pro Ile Lys Pro Met Gln Phe Leu Gly Asp Glu Glu Thr Val Arg 
225                 230                 235                 240 


Lys Ala Met Glu Ala Val Ala Ala Gln Gly Lys Ala Lys Lys 
                245                 250                 


<210>  18
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Gly Arg Gly Lys Gln Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly Asn Tyr Ser Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Lys Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Glu Ser His His Lys Ala Lys 
        115                 120                 125             


Gly Lys 
    130 


<210>  19
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala 
1               5                   10                  15      


Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 
            20                  25                  30          


Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 
        35                  40                  45              


Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 
    50                  55                  60                  


Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu 
65                  70                  75                  80  


Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 
                85                  90                  95      


Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 
            100                 105                 110         


Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 
        115                 120                 125             


Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 
    130                 135                 140                 


Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile 
145                 150                 155                 160 


Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 
                165                 170                 175     


Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 
            180                 185                 190         


Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 
        195                 200                 205             


Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 
    210                 215                 220                 


<210>  20
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Leu Ala Gly Val Cys Ala Leu Arg Arg Ser Ala Gly Tyr Ile 
1               5                   10                  15      


Leu Val Gly Gly Ala Gly Gly Gln Ser Ala Ala Ala Ala Ala Arg Arg 
            20                  25                  30          


Cys Ser Glu Gly Glu Trp Ala Ser Gly Gly Val Arg Ser Phe Ser Arg 
        35                  40                  45              


Ala Ala Ala Ala Met Ala Pro Ile Lys Val Gly Asp Ala Ile Pro Ala 
    50                  55                  60                  


Val Glu Val Phe Glu Gly Glu Pro Gly Asn Lys Val Asn Leu Ala Glu 
65                  70                  75                  80  


Leu Phe Lys Gly Lys Lys Gly Val Leu Phe Gly Val Pro Gly Ala Phe 
                85                  90                  95      


Thr Pro Gly Cys Ser Lys Thr His Leu Pro Gly Phe Val Glu Gln Ala 
            100                 105                 110         


Glu Ala Leu Lys Ala Lys Gly Val Gln Val Val Ala Cys Leu Ser Val 
        115                 120                 125             


Asn Asp Ala Phe Val Thr Gly Glu Trp Gly Arg Ala His Lys Ala Glu 
    130                 135                 140                 


Gly Lys Val Arg Leu Leu Ala Asp Pro Thr Gly Ala Phe Gly Lys Glu 
145                 150                 155                 160 


Thr Asp Leu Leu Leu Asp Asp Ser Leu Val Ser Ile Phe Gly Asn Arg 
                165                 170                 175     


Arg Leu Lys Arg Phe Ser Met Val Val Gln Asp Gly Ile Val Lys Ala 
            180                 185                 190         


Leu Asn Val Glu Pro Asp Gly Thr Gly Leu Thr Cys Ser Leu Ala Pro 
        195                 200                 205             


Asn Ile Ile Ser Gln Leu 
    210                 


<210>  21
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser Arg Glu Val Gln Gln 
1               5                   10                  15      


Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu Gln Ile Leu Ile Gln 
            20                  25                  30          


Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly Arg Pro Gln Pro Gly 
        35                  40                  45              


Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly Thr Val Leu Cys Glu 
    50                  55                  60                  


Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala Pro Val Lys Lys Ile 
65                  70                  75                  80  


Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu Gln Ile Ser Gln Phe 
                85                  90                  95      


Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr Thr Asp Ile Phe Gln 
            100                 105                 110         


Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala Cys Val Gln Arg Thr 
        115                 120                 125             


Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg Asp Asp Gly Leu Phe 
    130                 135                 140                 


Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser Lys Glu Asn Pro Arg 
145                 150                 155                 160 


Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys Asn Val Ile Gly Leu 
                165                 170                 175     


Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala Gly Met Thr Gly Tyr 
            180                 185                 190         


Gly Met Pro Arg Gln Ile Leu 
        195                 


<210>  22
<211>  463
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
    450                 455                 460             


<210>  23
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Arg Gly Pro Lys Lys His Leu Lys Arg Val Ala Ala Pro Lys 
1               5                   10                  15      


His Trp Met Leu Asp Lys Leu Thr Gly Val Phe Ala Pro Arg Pro Ser 
            20                  25                  30          


Thr Gly Pro His Lys Leu Arg Glu Cys Leu Pro Leu Ile Ile Phe Leu 
        35                  40                  45              


Arg Asn Arg Leu Lys Tyr Ala Leu Thr Gly Asp Glu Val Lys Lys Ile 
    50                  55                  60                  


Cys Met Gln Arg Phe Ile Lys Ile Asp Gly Lys Val Arg Thr Asp Ile 
65                  70                  75                  80  


Thr Tyr Pro Ala Gly Phe Met Asp Val Ile Ser Ile Asp Lys Thr Gly 
                85                  90                  95      


Glu Asn Phe Arg Leu Ile Tyr Asp Thr Lys Gly Arg Phe Ala Val His 
            100                 105                 110         


Arg Ile Thr Pro Glu Glu Ala Lys Tyr Lys Leu Cys Lys Val Arg Lys 
        115                 120                 125             


Ile Phe Val Gly Thr Lys Gly Ile Pro His Leu Val Thr His Asp Ala 
    130                 135                 140                 


Arg Thr Ile Arg Tyr Pro Asp Pro Leu Ile Lys Val Asn Asp Thr Ile 
145                 150                 155                 160 


Gln Ile Asp Leu Glu Thr Gly Lys Ile Thr Asp Phe Ile Lys Phe Asp 
                165                 170                 175     


Thr Gly Asn Leu Cys Met Val Thr Gly Gly Ala Asn Leu Gly Arg Ile 
            180                 185                 190         


Gly Val Ile Thr Asn Arg Glu Arg His Pro Gly Ser Phe Asp Val Val 
        195                 200                 205             


His Val Lys Asp Ala Asn Gly Asn Ser Phe Ala Thr Arg Leu Ser Asn 
    210                 215                 220                 


Ile Phe Val Ile Gly Lys Gly Asn Lys Pro Trp Ile Ser Leu Pro Arg 
225                 230                 235                 240 


Gly Lys Gly Ile Arg Leu Thr Ile Ala Glu Glu Arg Asp Lys Arg Leu 
                245                 250                 255     


Ala Ala Lys Gln Ser Ser Gly 
            260             


<210>  24
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Pro Lys Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu 
1               5                   10                  15      


Ala Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val 
            20                  25                  30          


His Ser His Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg 
        35                  40                  45              


Pro Lys Thr Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser 
    50                  55                  60                  


Ala Pro Arg Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro 
65                  70                  75                  80  


Leu Thr Thr Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu 
                85                  90                  95      


Val Phe Ile Val Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala 
            100                 105                 110         


Val Lys Lys Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile 
        115                 120                 125             


Arg Pro Asp Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr 
    130                 135                 140                 


Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
145                 150                 155     


<210>  25
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ser Gly Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala 
1               5                   10                  15      


Lys Arg His Arg Lys Val Leu Arg Asp Asn Ile Gln Gly Ile Thr Lys 
            20                  25                  30          


Pro Ala Ile Arg Arg Leu Ala Arg Arg Gly Gly Val Lys Arg Ile Ser 
        35                  40                  45              


Gly Leu Ile Tyr Glu Glu Thr Arg Gly Val Leu Lys Val Phe Leu Glu 
    50                  55                  60                  


Asn Val Ile Arg Asp Ala Val Thr Tyr Thr Glu His Ala Lys Arg Lys 
65                  70                  75                  80  


Thr Val Thr Ala Met Asp Val Val Tyr Ala Leu Lys Arg Gln Gly Arg 
                85                  90                  95      


Thr Leu Tyr Gly Phe Gly Gly 
            100             


<210>  26
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  27
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  28
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  29
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Val Asp Ile Arg His Asn Lys Asp Arg Lys Val Arg Arg Lys 
1               5                   10                  15      


Glu Pro Lys Ser Gln Asp Ile Tyr Leu Arg Leu Leu Val Lys Leu Tyr 
            20                  25                  30          


Arg Phe Leu Ala Arg Arg Thr Asn Ser Thr Phe Asn Gln Val Val Leu 
        35                  40                  45              


Lys Arg Leu Phe Met Ser Arg Thr Asn Arg Pro Pro Leu Ser Leu Ser 
    50                  55                  60                  


Arg Met Ile Arg Lys Met Lys Leu Pro Gly Arg Glu Asn Lys Thr Ala 
65                  70                  75                  80  


Val Val Val Gly Thr Ile Thr Asp Asp Val Arg Val Gln Glu Val Pro 
                85                  90                  95      


Lys Leu Lys Val Cys Ala Leu Arg Val Thr Ser Arg Ala Arg Ser Arg 
            100                 105                 110         


Ile Leu Arg Ala Gly Gly Lys Ile Leu Thr Phe Asp Gln Leu Ala Leu 
        115                 120                 125             


Asp Ser Pro Lys Gly Cys Gly Thr Val Leu Leu Ser Gly Pro Arg Lys 
    130                 135                 140                 


Gly Arg Glu Val Tyr Arg His Phe Gly Lys Ala Pro Gly Thr Pro His 
145                 150                 155                 160 


Ser His Thr Lys Pro Tyr Val Arg Ser Lys Gly Arg Lys Phe Glu Arg 
                165                 170                 175     


Ala Arg Gly Arg Arg Ala Ser Arg Gly Tyr Lys Asn 
            180                 185             


<210>  30
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Gly Trp Ala Asp Glu Arg Gly Gly Glu Gly Asp Gly Arg Ile 
1               5                   10                  15      


Tyr Val Gly Asn Leu Pro Thr Asp Val Arg Glu Lys Asp Leu Glu Asp 
            20                  25                  30          


Leu Phe Tyr Lys Tyr Gly Arg Ile Arg Glu Ile Glu Leu Lys Asn Arg 
        35                  40                  45              


His Gly Leu Val Pro Phe Ala Phe Val Arg Phe Glu Asp Pro Arg Asp 
    50                  55                  60                  


Ala Glu Asp Ala Ile Tyr Gly Arg Asn Gly Tyr Asp Tyr Gly Gln Cys 
65                  70                  75                  80  


Arg Leu Arg Val Glu Phe Pro Arg Thr Tyr Gly Gly Arg Gly Gly Trp 
                85                  90                  95      


Pro Arg Gly Gly Arg Asn Gly Pro Pro Thr Arg Arg Ser Asp Phe Arg 
            100                 105                 110         


Val Leu Val Ser Gly Leu Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys 
        115                 120                 125             


Asp His Met Arg Glu Ala Gly Asp Val Cys Tyr Ala Asp Val Gln Lys 
    130                 135                 140                 


Asp Gly Val Gly Met Val Glu Tyr Leu Arg Lys Glu Asp Met Glu Tyr 
145                 150                 155                 160 


Ala Leu Arg Lys Leu Asp Asp Thr Lys Phe Arg Ser His Glu Gly Glu 
                165                 170                 175     


Thr Ser Tyr Ile Arg Val Tyr Pro Glu Arg Ser Thr Ser Tyr Gly Tyr 
            180                 185                 190         


Ser Arg Ser Arg Ser Gly Ser Arg Gly Arg Asp Ser Pro Tyr Gln Ser 
        195                 200                 205             


Arg Gly Ser Pro His Tyr Phe Ser Pro Phe Arg Pro Tyr 
    210                 215                 220     


<210>  31
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Val Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Met Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ser Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Val 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  32
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Thr Lys Lys Arg Arg Asn Asn Ser His Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Ile Arg Cys Thr Asn Cys Val Arg Cys Val Pro Thr 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Val Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Cys Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 


<210>  33
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Gly Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Thr Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  34
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Trp Leu Cys Pro Leu Ala Leu Asn Leu Ile Leu Met Ala Ala Ser 
1               5                   10                  15      


Gly Ala Val Cys Glu Val Lys Asp Val Cys Val Gly Ser Pro Gly Ile 
            20                  25                  30          


Pro Gly Thr Pro Gly Ser His Gly Leu Pro Gly Arg Asp Gly Arg Asp 
        35                  40                  45              


Gly Leu Lys Gly Asp Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly 
    50                  55                  60                  


Glu Met Pro Cys Pro Pro Gly Asn Asp Gly Leu Pro Gly Ala Pro Gly 
65                  70                  75                  80  


Ile Pro Gly Glu Cys Gly Glu Lys Gly Glu Pro Gly Glu Arg Gly Pro 
                85                  90                  95      


Pro Gly Leu Pro Ala His Leu Asp Glu Glu Leu Gln Ala Thr Leu His 
            100                 105                 110         


Asp Phe Arg His Gln Ile Leu Gln Thr Arg Gly Ala Leu Ser Leu Gln 
        115                 120                 125             


Gly Ser Ile Met Thr Val Gly Glu Lys Val Phe Ser Ser Asn Gly Gln 
    130                 135                 140                 


Ser Ile Thr Phe Asp Ala Ile Gln Glu Ala Cys Ala Arg Ala Gly Gly 
145                 150                 155                 160 


Arg Ile Ala Val Pro Arg Asn Pro Glu Glu Asn Glu Ala Ile Ala Ser 
                165                 170                 175     


Phe Val Lys Lys Tyr Asn Thr Tyr Ala Tyr Val Gly Leu Thr Glu Gly 
            180                 185                 190         


Pro Ser Pro Gly Asp Phe Arg Tyr Ser Asp Gly Thr Pro Val Asn Tyr 
        195                 200                 205             


Thr Asn Trp Tyr Arg Gly Glu Pro Ala Gly Arg Gly Lys Glu Gln Cys 
    210                 215                 220                 


Val Glu Met Tyr Thr Asp Gly Gln Trp Asn Asp Arg Asn Cys Leu Tyr 
225                 230                 235                 240 


Ser Arg Leu Thr Ile Cys Glu Phe 
                245             


<210>  35
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Ala Ser Val Glu Gln Arg Glu Gly Thr Ile Gln Val Gln Gly 
1               5                   10                  15      


Gln Ala Leu Phe Phe Arg Glu Ala Leu Pro Gly Ser Gly Gln Ala Arg 
            20                  25                  30          


Phe Ser Val Leu Leu Leu His Gly Ile Arg Phe Ser Ser Glu Thr Trp 
        35                  40                  45              


Gln Asn Leu Gly Thr Leu His Arg Leu Ala Gln Ala Gly Tyr Arg Ala 
    50                  55                  60                  


Val Ala Ile Asp Leu Pro Gly Leu Gly His Ser Lys Glu Ala Ala Ala 
65                  70                  75                  80  


Pro Ala Pro Ile Gly Glu Leu Ala Pro Gly Ser Phe Leu Ala Ala Val 
                85                  90                  95      


Val Asp Ala Leu Glu Leu Gly Pro Pro Val Val Ile Ser Pro Ser Leu 
            100                 105                 110         


Ser Gly Met Tyr Ser Leu Pro Phe Leu Thr Ala Pro Gly Ser Gln Leu 
        115                 120                 125             


Pro Gly Phe Val Pro Val Ala Pro Ile Cys Thr Asp Lys Ile Asn Ala 
    130                 135                 140                 


Ala Asn Tyr Ala Ser Val Lys Thr Pro Ala Leu Ile Val Tyr Gly Asp 
145                 150                 155                 160 


Gln Asp Pro Met Gly Gln Thr Ser Phe Glu His Leu Lys Gln Leu Pro 
                165                 170                 175     


Asn His Arg Val Leu Ile Met Lys Gly Ala Gly His Pro Cys Tyr Leu 
            180                 185                 190         


Asp Lys Pro Glu Glu Trp His Thr Gly Leu Leu Asp Phe Leu Gln Gly 
        195                 200                 205             


Leu Gln 
    210 


