                         SEQUENCE LISTING

<110>  Monash University
       Ludwig Institute for Cancer Research Limited
 
<120>  Antibodies directed to the receptor tyrosine kinase c-Met

<130>  510870

<140>  US 61/396691
<141>  2011-06-01

<150>  US 61/396691
<151>  2010-06-01

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  555
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of residues 1-567 of human c-Met

<400>  1

Glu Thr Arg Glu Cys Lys Glu Ala Leu Ala Lys Ser Glu Met Asn Val 
1               5                   10                  15      


Asn Met Lys Tyr Gln Leu Pro Asn Phe Thr Ala Glu Thr Pro Ile Gln 
            20                  25                  30          


Asn Val Ile Leu His Glu His His Ile Phe Leu Gly Ala Thr Asn Tyr 
        35                  40                  45              


Ile Tyr Val Leu Asn Glu Glu Asp Leu Gln Lys Val Ala Glu Tyr Lys 
    50                  55                  60                  


Thr Gly Pro Val Leu Glu His Pro Asp Cys Phe Pro Cys Gln Asp Cys 
65                  70                  75                  80  


Ser Ser Lys Ala Asn Leu Ser Gly Gly Val Trp Lys Asp Asn Ile Asn 
                85                  90                  95      


Met Ala Leu Val Val Asp Thr Tyr Tyr Asp Asp Gln Leu Ile Ser Cys 
            100                 105                 110         


Gly Ser Val Asn Arg Gly Thr Cys Gln Arg His Val Phe Pro His Asn 
        115                 120                 125             


His Thr Ala Asp Ile Gln Ser Glu Val His Cys Ile Phe Ser Pro Gln 
    130                 135                 140                 


Ile Glu Glu Pro Ser Gln Cys Pro Asp Cys Val Val Ser Ala Leu Gly 
145                 150                 155                 160 


Ala Lys Val Leu Ser Ser Val Lys Asp Arg Phe Ile Asn Phe Phe Val 
                165                 170                 175     


Gly Asn Thr Ile Asn Ser Ser Tyr Phe Pro Asp His Pro Leu His Ser 
            180                 185                 190         


Ile Ser Val Arg Arg Leu Lys Glu Thr Lys Asp Gly Phe Met Phe Leu 
        195                 200                 205             


Thr Asp Gln Ser Tyr Ile Asp Val Leu Pro Glu Phe Arg Asp Ser Tyr 
    210                 215                 220                 


Pro Ile Lys Tyr Val His Ala Phe Glu Ser Asn Asn Phe Ile Tyr Phe 
225                 230                 235                 240 


Leu Thr Val Gln Arg Glu Thr Leu Asp Ala Gln Thr Phe His Thr Arg 
                245                 250                 255     


Ile Ile Arg Phe Cys Ser Ile Asn Ser Gly Leu His Ser Tyr Met Glu 
            260                 265                 270         


Met Pro Leu Glu Cys Ile Leu Thr Glu Lys Arg Lys Lys Arg Ser Thr 
        275                 280                 285             


Lys Lys Glu Val Phe Asn Ile Leu Gln Ala Ala Tyr Val Ser Lys Pro 
    290                 295                 300                 


Gly Ala Gln Leu Ala Arg Gln Ile Gly Ala Ser Leu Asn Asp Asp Ile 
305                 310                 315                 320 


Leu Phe Gly Val Phe Ala Gln Ser Lys Pro Asp Ser Ala Glu Pro Met 
                325                 330                 335     


Asp Arg Ser Ala Met Cys Ala Phe Pro Ile Lys Tyr Val Asn Asp Phe 
            340                 345                 350         


Phe Asn Lys Ile Val Asn Lys Asn Asn Val Arg Cys Leu Gln His Phe 
        355                 360                 365             


Tyr Gly Pro Asn His Glu His Cys Phe Asn Arg Thr Leu Leu Arg Asn 
    370                 375                 380                 


Ser Ser Gly Cys Glu Ala Arg Arg Asp Glu Tyr Arg Thr Glu Phe Thr 
385                 390                 395                 400 


Thr Ala Leu Gln Arg Val Asp Leu Phe Met Gly Gln Phe Ser Glu Val 
                405                 410                 415     


Leu Leu Thr Ser Ile Ser Thr Phe Ile Lys Gly Asp Leu Thr Ile Ala 
            420                 425                 430         


Asn Leu Gly Thr Ser Glu Gly Arg Phe Met Gln Val Val Val Ser Arg 
        435                 440                 445             


Ser Gly Pro Ser Thr Pro His Val Asn Phe Leu Leu Asp Ser His Pro 
    450                 455                 460                 


Val Ser Pro Glu Val Ile Val Glu His Thr Leu Asn Gln Asn Gly Tyr 
465                 470                 475                 480 


Thr Leu Val Ile Thr Gly Lys Lys Ile Thr Lys Ile Pro Leu Asn Gly 
                485                 490                 495     


Leu Gly Cys Arg His Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro 
            500                 505                 510         


Pro Phe Val Gln Cys Gly Trp Cys His Asp Lys Cys Val Arg Ser Glu 
        515                 520                 525             


Glu Cys Leu Ser Gly Thr Trp Thr Gln Gln Ile Cys Leu Pro Ala Ile 
    530                 535                 540                 


Tyr Lys Ala Asp Leu His His His His His His 
545                 550                 555 


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence of antibody LHM-82

<400>  2

Val Val Asp Thr Tyr Tyr Asp Asp Gln Leu 
1               5                   10  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence of LMH-84

<400>  3

Val Arg Arg Leu Lys Glu Thr Lys Asp Gly Phe Met Phe Leu Thr 
1               5                   10                  15  


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence of LMH-86, LMH-87, LMH-88 and LMH-89

<400>  4

Asp Val Leu Pro Glu Phe Arg Asp Ser Tyr 
1               5                   10  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence of LMH-81

<400>  5

Arg His Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Pro Phe Val 
1               5                   10                  15      


Gln Cys Gly Trp 
            20  


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope sequence of LMH-80

<400>  6

Arg His Phe Gln Ser Cys Ser Gln Cys Leu Ser Ala Pro Pro Phe 
1               5                   10                  15  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH1 of LMH-80

<400>  7

Gly Tyr Thr Phe Thr Asp Asn Ser 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2 of LMH-80

<400>  8

Val Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  9
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH3 of LMH-80

<400>  9

Ala Arg Asp Gly His Tyr Phe Ala Tyr 
1               5                   


<210>  10
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL1 of LMH-80

<400>  10

Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asp Tyr 
1               5                   10          


<210>  11
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL2 of LMH-80

<400>  11

Trp Ala Ser 
1           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL3 of LMH-80

<400>  12

Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  13
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Heavy chain variable region sequence of LMH-80

<400>  13

Lys Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Asn 
            20                  25                  30          


Ser Met His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Val Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Gly His Tyr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  14
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain variable region sequence of LMH-80

<400>  14

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Ala Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  15
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH1 of LMH-82

<400>  15

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH2 of LMH-82

<400>  16

Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               


<210>  17
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRH3 of LMH-82

<400>  17

Ala Arg Ser Gly Tyr 
1               5   


<210>  18
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL1 of LMH-82

<400>  18

Gln Ser Ile Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  19
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL2 of LMH-82

<400>  19

Lys Val Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL3 of LMH-82

<400>  20

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  21
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain variable region sequence of LMH-82

<400>  21

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


<210>  22
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain variable region sequence of LMH-82.

<400>  22

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 sequence of antibody LMH-87

<400>  23

Gly Asn Thr Leu Lys Asp Asp His 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 sequence of antibody LMH-87

<400>  24

Ile Tyr Pro Gly Gly Gly Arg Thr 
1               5               


<210>  25
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 sequence of antibody LMH-87

<400>  25

Thr Asn Leu Val Phe Asp Val 
1               5           


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 sequence of antibody LMH-87

<400>  26

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 sequence of antibody LMH-87

<400>  27

Arg Met Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 sequence of antibody LMH-87

<400>  28

Met Gln Asn Leu Glu Tyr Pro Phe Thr 
1               5                   


<210>  29
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence of antibody LMH-87

<400>  29

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Asn Thr Leu Lys Asp Asp 
            20                  25                  30          


His Val His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Gly Gly Arg Thr Arg Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Pro Ser Ser Thr Val Asn 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Asn Leu Val Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region of antibody LMH-87

<400>  30

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Val Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Arg Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Asn 
                85                  90                  95      


Leu Glu Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 sequence of antibody LMH-85

<400>  31

Gly Tyr Thr Phe Ile Ile Tyr Trp 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 sequence of antibody LMH-85

<400>  32

Ile Asn Pro Ser Asn Asp Tyr Thr 
1               5               


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 sequence of antibody LMH-85

<400>  33

Ala Arg Asp Ser Tyr Asp Tyr Asp Asp Gly Ala Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 sequence of antibody LMH-85

<400>  34

Ser Gly Val Asn Tyr 
1               5   


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 sequence of antibody LMH-85

<400>  35

Ala Thr Ser 
1           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 sequence of antibody LMH-85.

<400>  36

Gln Gln Trp Ile Ser His Pro Phe Thr 
1               5                   


<210>  37
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence of LMH-85

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Ile Tyr 
            20                  25                  30          


Trp Ile His Trp Ile Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Asn Asp Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Asp Tyr Asp Asp Gly Ala Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  38
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence of LMH-85

<400>  38

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Gly Val Asn Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ile Ser His Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  39
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region of antibody LMH-87

<400>  39
caggtccagc tgcagcagtc tggacctgag ctggtgaagt ctggggcttc agtgaagatg       60

tcctgcaagg cttctgggaa caccctcaaa gacgaccatg tacactgggt gaagcagagg      120

cctggacagg gccttgagtg gattggatgg atttatcctg gaggtggtag gacaaggtac      180

aatgagaagt tcaagggcaa gaccacactg actgcagaca aaccctccag cacagttaac      240

atgttgctca gtagcctgac ctctgaggac tctgcgatct atttctgtac aaacttggtt      300

ttcgatgtct ggggtgcagg gaccacggtc accgtctcct ca                         342


<210>  40
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence of LMH-87

<400>  40
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg      120

ttcctgcaga ggccaggcca gtctcctcag gtcctgatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      240

agaagagtgg aggctgagga tgtgggtgtt tattactgta tgcaaaatct agaatatcct      300

ttcacattcg gaggggggac caagctggaa ataaaa                                336


<210>  41
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  heavy chain variable region sequence of antibody LMH-85.

<400>  41
caggtccagc ttcagcagtc tggggctgaa ctggcaaaac ctggggcctc agtgaagatg       60

tcctgcaagg cttctggcta cacctttatc atctactgga ttcactggat aaaacagagg      120

cctggacagg gtctggaatg gattgggtac attaatccta gtaatgacta tactgagtac      180

aatcagaagt tcaaggacaa ggccacattg actgcagaca aatcctccaa cacagccttc      240

atgcaactga gcagcctgac atctgaggac tctgcagtct attactgtgc aagagattcc      300

tatgattacg acgacggggc ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtctcctca                                                              369


<210>  42
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  light chain variable region sequence of antibody LMH-85

<400>  42
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcact       60

atgacttgca gggccagctc aggtgtaaat tacatgcact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccact tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg attagtcacc cattcacgtt cggctcgggg      300

acaaagttgg aaataaaa                                                    318


